-- dump date 20111121_015335 -- class Genbank::misc_feature -- table misc_feature_note -- id note 795359000001 hypothetical protein; Validated; Region: PRK06672 795359000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 795359000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359000004 Walker A motif; other site 795359000005 ATP binding site [chemical binding]; other site 795359000006 Walker B motif; other site 795359000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 795359000008 DnaA box-binding interface [nucleotide binding]; other site 795359000009 FAD binding domain; Region: FAD_binding_4; pfam01565 795359000010 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 795359000011 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 795359000012 Ligand Binding Site [chemical binding]; other site 795359000013 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 795359000014 N-acetyl-D-glucosamine binding site [chemical binding]; other site 795359000015 catalytic residue [active] 795359000016 Mechanosensitive ion channel; Region: MS_channel; pfam00924 795359000017 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 795359000018 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 795359000019 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 795359000020 PilZ domain; Region: PilZ; cl01260 795359000021 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 795359000022 putative carbohydrate kinase; Provisional; Region: PRK10565 795359000023 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 795359000024 putative substrate binding site [chemical binding]; other site 795359000025 putative ATP binding site [chemical binding]; other site 795359000026 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 795359000027 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 795359000028 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 795359000029 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 795359000030 dimer interface [polypeptide binding]; other site 795359000031 active site 795359000032 Phosphopantetheine attachment site; Region: PP-binding; cl09936 795359000033 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 795359000034 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 795359000035 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 795359000036 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 795359000037 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 795359000038 HemN C-terminal region; Region: HemN_C; pfam06969 795359000039 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 795359000040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 795359000041 S-adenosylmethionine binding site [chemical binding]; other site 795359000042 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 795359000043 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359000044 FeS/SAM binding site; other site 795359000045 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 795359000046 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359000047 FeS/SAM binding site; other site 795359000048 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 795359000049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359000050 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 795359000051 putative L-serine binding site [chemical binding]; other site 795359000052 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 795359000053 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-...; Region: AGAT_like; cd06451 795359000054 homodimer interface [polypeptide binding]; other site 795359000055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 795359000056 catalytic residue [active] 795359000057 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 795359000058 domain; Region: GreA_GreB_N; pfam03449 795359000059 C-term; Region: GreA_GreB; pfam01272 795359000060 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 795359000061 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 795359000062 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 795359000063 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 795359000064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359000065 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 795359000066 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 795359000067 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 795359000068 active site 795359000069 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 795359000070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 795359000071 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 795359000072 mce related protein; Region: MCE; pfam02470 795359000073 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 795359000074 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 795359000075 Walker A/P-loop; other site 795359000076 ATP binding site [chemical binding]; other site 795359000077 Q-loop/lid; other site 795359000078 ABC transporter signature motif; other site 795359000079 Walker B; other site 795359000080 D-loop; other site 795359000081 H-loop/switch region; other site 795359000082 Domain of unknown function DUF140; Region: DUF140; cl00510 795359000083 Dehydratase family; Region: ILVD_EDD; cl00340 795359000084 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 795359000085 NifU-like domain; Region: NifU; cl00484 795359000086 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 795359000087 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 795359000088 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 795359000089 HSP70 interaction site [polypeptide binding]; other site 795359000090 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 795359000091 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 795359000092 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 795359000093 trimer interface [polypeptide binding]; other site 795359000094 dimer interface [polypeptide binding]; other site 795359000095 putative active site [active] 795359000096 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 795359000097 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 795359000098 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359000099 Walker A/P-loop; other site 795359000100 ATP binding site [chemical binding]; other site 795359000101 Q-loop/lid; other site 795359000102 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359000103 ABC transporter signature motif; other site 795359000104 Walker B; other site 795359000105 D-loop; other site 795359000106 H-loop/switch region; other site 795359000107 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359000108 Walker A/P-loop; other site 795359000109 ATP binding site [chemical binding]; other site 795359000110 Q-loop/lid; other site 795359000111 ABC transporter signature motif; other site 795359000112 Walker B; other site 795359000113 D-loop; other site 795359000114 H-loop/switch region; other site 795359000115 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 795359000116 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 795359000117 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 795359000118 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359000119 Walker A/P-loop; other site 795359000120 ATP binding site [chemical binding]; other site 795359000121 Q-loop/lid; other site 795359000122 ABC transporter signature motif; other site 795359000123 Walker B; other site 795359000124 D-loop; other site 795359000125 H-loop/switch region; other site 795359000126 FOG: CBS domain [General function prediction only]; Region: COG0517 795359000127 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 795359000128 Domain of unknown function DUF39; Region: DUF39; cl14897 795359000129 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 795359000130 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 795359000131 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 795359000132 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 795359000133 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 795359000134 active site 795359000135 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 795359000136 protein binding site [polypeptide binding]; other site 795359000137 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 795359000138 putative substrate binding region [chemical binding]; other site 795359000139 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 795359000140 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 795359000141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 795359000142 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 795359000143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 795359000144 dimer interface [polypeptide binding]; other site 795359000145 conserved gate region; other site 795359000146 putative PBP binding loops; other site 795359000147 ABC-ATPase subunit interface; other site 795359000148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359000149 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 795359000150 Walker A motif; other site 795359000151 ATP binding site [chemical binding]; other site 795359000152 Walker B motif; other site 795359000153 arginine finger; other site 795359000154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359000155 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 795359000156 Walker A motif; other site 795359000157 ATP binding site [chemical binding]; other site 795359000158 Walker B motif; other site 795359000159 arginine finger; other site 795359000160 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 795359000161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359000162 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 795359000163 Walker A motif; other site 795359000164 ATP binding site [chemical binding]; other site 795359000165 Walker B motif; other site 795359000166 arginine finger; other site 795359000167 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 795359000168 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 795359000169 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 795359000170 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 795359000171 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 795359000172 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 795359000173 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 795359000174 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 795359000175 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 795359000176 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 795359000177 FliG C-terminal domain; Region: FliG_C; pfam01706 795359000178 Flagellar assembly protein FliH; Region: FliH; pfam02108 795359000179 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 795359000180 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 795359000181 Walker A motif/ATP binding site; other site 795359000182 Walker B motif; other site 795359000183 UL45 protein; Region: Herpes_UL45; pfam05473 795359000184 MgtE intracellular N domain; Region: MgtE_N; cl15244 795359000185 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 795359000186 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 795359000187 putative active site [active] 795359000188 catalytic triad [active] 795359000189 Protein of unknown function, DUF399; Region: DUF399; cl01139 795359000190 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 795359000191 IHF - DNA interface [nucleotide binding]; other site 795359000192 IHF dimer interface [polypeptide binding]; other site 795359000193 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 795359000194 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 795359000195 DNA binding site [nucleotide binding] 795359000196 catalytic residue [active] 795359000197 H2TH interface [polypeptide binding]; other site 795359000198 putative catalytic residues [active] 795359000199 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 795359000200 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 795359000201 Domain of unknown function DUF20; Region: UPF0118; cl00465 795359000202 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 795359000203 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 795359000204 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 795359000205 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 795359000206 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 795359000207 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 795359000208 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 795359000209 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 795359000210 5S rRNA interface [nucleotide binding]; other site 795359000211 CTC domain interface [polypeptide binding]; other site 795359000212 L16 interface [polypeptide binding]; other site 795359000213 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 795359000214 putative active site [active] 795359000215 catalytic residue [active] 795359000216 GMP synthase; Reviewed; Region: guaA; PRK00074 795359000217 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 795359000218 AMP/PPi binding site [chemical binding]; other site 795359000219 candidate oxyanion hole; other site 795359000220 catalytic triad [active] 795359000221 potential glutamine specificity residues [chemical binding]; other site 795359000222 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 795359000223 ATP Binding subdomain [chemical binding]; other site 795359000224 Ligand Binding sites [chemical binding]; other site 795359000225 Dimerization subdomain; other site 795359000226 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 795359000227 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 795359000228 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 795359000229 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 795359000230 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 795359000231 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 795359000232 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 795359000233 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 795359000234 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 795359000235 dimer interface [polypeptide binding]; other site 795359000236 active site 795359000237 CoA binding pocket [chemical binding]; other site 795359000238 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 795359000239 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 795359000240 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 795359000241 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 795359000242 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 795359000243 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 795359000244 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 795359000245 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 795359000246 Flagellar hook capping protein; Region: FlgD; cl04347 795359000247 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 795359000248 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 795359000249 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 795359000250 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 795359000251 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 795359000252 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 795359000253 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 795359000254 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 795359000255 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 795359000256 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 795359000257 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 795359000258 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 795359000259 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 795359000260 4Fe-4S binding domain; Region: Fer4; cl02805 795359000261 NADH dehydrogenase; Region: NADHdh; cl00469 795359000262 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 795359000263 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 795359000264 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 795359000265 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 795359000266 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 795359000267 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 795359000268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359000269 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 795359000270 substrate binding site [chemical binding]; other site 795359000271 dimer interface [polypeptide binding]; other site 795359000272 catalytic triad [active] 795359000273 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 795359000274 substrate binding site [chemical binding]; other site 795359000275 hinge regions; other site 795359000276 ADP binding site [chemical binding]; other site 795359000277 catalytic site [active] 795359000278 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 795359000279 homopentamer interface [polypeptide binding]; other site 795359000280 active site 795359000281 Septum formation initiator; Region: DivIC; cl11433 795359000282 phosphoenolpyruvate synthase; Validated; Region: PRK06464 795359000283 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 795359000284 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 795359000285 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 795359000286 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 795359000287 SmpB-tmRNA interface; other site 795359000288 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359000289 Walker A/P-loop; other site 795359000290 ATP binding site [chemical binding]; other site 795359000291 Q-loop/lid; other site 795359000292 Walker B; other site 795359000293 D-loop; other site 795359000294 H-loop/switch region; other site 795359000295 exonuclease SbcC; Region: sbcc; TIGR00618 795359000296 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359000297 ABC transporter signature motif; other site 795359000298 Walker B; other site 795359000299 D-loop; other site 795359000300 H-loop/switch region; other site 795359000301 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 795359000302 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 795359000303 GTP binding site [chemical binding]; other site 795359000304 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 795359000305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359000306 active site 795359000307 phosphorylation site [posttranslational modification] 795359000308 intermolecular recognition site; other site 795359000309 dimerization interface [polypeptide binding]; other site 795359000310 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 795359000311 Zn2+ binding site [ion binding]; other site 795359000312 Mg2+ binding site [ion binding]; other site 795359000313 Protein of unknown function DUF72; Region: DUF72; cl00777 795359000314 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 795359000315 Putative periplasminc binding protein (DUF178); Region: DUF178; cl15271 795359000316 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 795359000317 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 795359000318 catalytic residues [active] 795359000319 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 795359000320 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 795359000321 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 795359000322 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359000323 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 795359000324 Uncharacterized conserved protein [Function unknown]; Region: COG0585 795359000325 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 795359000326 active site 795359000327 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 795359000328 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 795359000329 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 795359000330 putative active site [active] 795359000331 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 795359000332 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 795359000333 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 795359000334 enolase; Provisional; Region: eno; PRK00077 795359000335 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 795359000336 dimer interface [polypeptide binding]; other site 795359000337 metal binding site [ion binding]; metal-binding site 795359000338 substrate binding pocket [chemical binding]; other site 795359000339 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 795359000340 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 795359000341 putative ribose interaction site [chemical binding]; other site 795359000342 putative ADP binding site [chemical binding]; other site 795359000343 recombinase A; Provisional; Region: recA; PRK09354 795359000344 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359000345 Walker A motif; other site 795359000346 ATP binding site [chemical binding]; other site 795359000347 Walker B motif; other site 795359000348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359000349 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 795359000350 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 795359000351 active site 795359000352 metal binding site [ion binding]; metal-binding site 795359000353 DNA binding site [nucleotide binding] 795359000354 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 795359000355 dihydrodipicolinate reductase; Provisional; Region: PRK00048 795359000356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359000357 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 795359000358 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 795359000359 Walker A motif; other site 795359000360 Domain of unknown function (DUF364); Region: DUF364; cl00885 795359000361 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 795359000362 acetylornithine aminotransferase; Provisional; Region: PRK02627 795359000363 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 795359000364 inhibitor-cofactor binding pocket; inhibition site 795359000365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 795359000366 catalytic residue [active] 795359000367 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 795359000368 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 795359000369 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359000370 FeS/SAM binding site; other site 795359000371 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 795359000372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359000373 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 795359000374 Active_site [active] 795359000375 HsdM N-terminal domain; Region: HsdM_N; pfam12161 795359000376 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 795359000377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359000378 TIR domain; Region: TIR; cl02060 795359000379 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 795359000380 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 795359000381 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 795359000382 active site 795359000383 NTP binding site [chemical binding]; other site 795359000384 metal binding triad [ion binding]; metal-binding site 795359000385 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 795359000386 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 795359000387 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 795359000388 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 795359000389 ATP binding site [chemical binding]; other site 795359000390 putative Mg++ binding site [ion binding]; other site 795359000391 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359000392 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 795359000393 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 795359000394 Flavin Reductases; Region: FlaRed; cl00801 795359000395 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 795359000396 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 795359000397 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 795359000398 catalytic motif [active] 795359000399 Zn binding site [ion binding]; other site 795359000400 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 795359000401 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 795359000402 CoA-binding site [chemical binding]; other site 795359000403 ATP-binding [chemical binding]; other site 795359000404 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 795359000405 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 795359000406 RNA binding surface [nucleotide binding]; other site 795359000407 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 795359000408 active site 795359000409 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 795359000410 Peptidase family M23; Region: Peptidase_M23; pfam01551 795359000411 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 795359000412 16S/18S rRNA binding site [nucleotide binding]; other site 795359000413 S13e-L30e interaction site [polypeptide binding]; other site 795359000414 25S rRNA binding site [nucleotide binding]; other site 795359000415 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 795359000416 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 795359000417 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 795359000418 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 795359000419 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 795359000420 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 795359000421 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 795359000422 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 795359000423 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 795359000424 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 795359000425 DNA binding site [nucleotide binding] 795359000426 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 795359000427 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 795359000428 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 795359000429 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 795359000430 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 795359000431 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 795359000432 RPB11 interaction site [polypeptide binding]; other site 795359000433 RPB12 interaction site [polypeptide binding]; other site 795359000434 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 795359000435 RPB3 interaction site [polypeptide binding]; other site 795359000436 RPB1 interaction site [polypeptide binding]; other site 795359000437 RPB11 interaction site [polypeptide binding]; other site 795359000438 RPB10 interaction site [polypeptide binding]; other site 795359000439 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 795359000440 peripheral dimer interface [polypeptide binding]; other site 795359000441 core dimer interface [polypeptide binding]; other site 795359000442 L10 interface [polypeptide binding]; other site 795359000443 L11 interface [polypeptide binding]; other site 795359000444 putative EF-Tu interaction site [polypeptide binding]; other site 795359000445 putative EF-G interaction site [polypeptide binding]; other site 795359000446 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 795359000447 23S rRNA interface [nucleotide binding]; other site 795359000448 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 795359000449 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 795359000450 mRNA/rRNA interface [nucleotide binding]; other site 795359000451 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 795359000452 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 795359000453 23S rRNA interface [nucleotide binding]; other site 795359000454 L7/L12 interface [polypeptide binding]; other site 795359000455 putative thiostrepton binding site; other site 795359000456 L25 interface [polypeptide binding]; other site 795359000457 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 795359000458 KOW motif; Region: KOW; cl00354 795359000459 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 795359000460 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 795359000461 elongation factor Tu; Reviewed; Region: PRK00049 795359000462 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 795359000463 G1 box; other site 795359000464 GEF interaction site [polypeptide binding]; other site 795359000465 GTP/Mg2+ binding site [chemical binding]; other site 795359000466 Switch I region; other site 795359000467 G2 box; other site 795359000468 G3 box; other site 795359000469 Switch II region; other site 795359000470 G4 box; other site 795359000471 G5 box; other site 795359000472 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 795359000473 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 795359000474 Antibiotic Binding Site [chemical binding]; other site 795359000475 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 795359000476 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 795359000477 CitB domain protein; Region: CitB; TIGR02484 795359000478 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 795359000479 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 795359000480 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 795359000481 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 795359000482 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 795359000483 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 795359000484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359000485 domain; Region: Succ_DH_flav_C; pfam02910 795359000486 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 795359000487 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 795359000488 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 795359000489 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]; Region: MET3; COG2046 795359000490 ATP-sulfurylase; Region: ATPS; cd00517 795359000491 active site 795359000492 HXXH motif; other site 795359000493 flexible loop; other site 795359000494 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 795359000495 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 795359000496 substrate binding pocket [chemical binding]; other site 795359000497 chain length determination region; other site 795359000498 substrate-Mg2+ binding site; other site 795359000499 catalytic residues [active] 795359000500 aspartate-rich region 1; other site 795359000501 active site lid residues [active] 795359000502 aspartate-rich region 2; other site 795359000503 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 795359000504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 795359000505 motif II; other site 795359000506 UvrD/REP helicase; Region: UvrD-helicase; cl14126 795359000507 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 795359000508 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 795359000509 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 795359000510 universal stress protein UspE; Provisional; Region: PRK11175 795359000511 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 795359000512 Ligand Binding Site [chemical binding]; other site 795359000513 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 795359000514 Ligand Binding Site [chemical binding]; other site 795359000515 replicative DNA helicase; Region: DnaB; TIGR00665 795359000516 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 795359000517 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 795359000518 Walker A motif; other site 795359000519 ATP binding site [chemical binding]; other site 795359000520 Walker B motif; other site 795359000521 DNA binding loops [nucleotide binding] 795359000522 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 795359000523 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 795359000524 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 795359000525 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 795359000526 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 795359000527 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 795359000528 active site 795359000529 8-oxo-dGMP binding site [chemical binding]; other site 795359000530 nudix motif; other site 795359000531 metal binding site [ion binding]; metal-binding site 795359000532 adenylosuccinate lyase; Provisional; Region: PRK07492 795359000533 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 795359000534 tetramer interface [polypeptide binding]; other site 795359000535 active site 795359000536 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 795359000537 putative peptidoglycan binding site; other site 795359000538 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 795359000539 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 795359000540 putative peptidoglycan binding site; other site 795359000541 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 795359000542 putative peptidoglycan binding site; other site 795359000543 NlpC/P60 family; Region: NLPC_P60; cl11438 795359000544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359000545 Response regulator receiver domain; Region: Response_reg; pfam00072 795359000546 active site 795359000547 phosphorylation site [posttranslational modification] 795359000548 intermolecular recognition site; other site 795359000549 dimerization interface [polypeptide binding]; other site 795359000550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 795359000551 metal binding site [ion binding]; metal-binding site 795359000552 active site 795359000553 I-site; other site 795359000554 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 795359000555 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 795359000556 putative active site [active] 795359000557 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 795359000558 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359000559 thymidylate kinase; Validated; Region: tmk; PRK00698 795359000560 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 795359000561 TMP-binding site; other site 795359000562 ATP-binding site [chemical binding]; other site 795359000563 Smr domain; Region: Smr; cl02619 795359000564 hypothetical protein; Reviewed; Region: PRK09588 795359000565 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 795359000566 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 795359000567 active site 795359000568 HslU subunit interaction site [polypeptide binding]; other site 795359000569 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 795359000570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359000571 Walker A motif; other site 795359000572 ATP binding site [chemical binding]; other site 795359000573 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359000574 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 795359000575 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 795359000576 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 795359000577 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359000578 FeS/SAM binding site; other site 795359000579 TRAM domain; Region: TRAM; cl01282 795359000580 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 795359000581 tetramerization interface [polypeptide binding]; other site 795359000582 active site 795359000583 Pantoate-beta-alanine ligase; Region: PanC; cd00560 795359000584 pantoate--beta-alanine ligase; Region: panC; TIGR00018 795359000585 active site 795359000586 ATP-binding site [chemical binding]; other site 795359000587 pantoate-binding site; other site 795359000588 HXXH motif; other site 795359000589 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 795359000590 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 795359000591 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 795359000592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359000593 binding surface 795359000594 TPR motif; other site 795359000595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359000596 binding surface 795359000597 TPR motif; other site 795359000598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359000599 binding surface 795359000600 TPR motif; other site 795359000601 2-isopropylmalate synthase; Validated; Region: PRK00915 795359000602 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 795359000603 active site 795359000604 catalytic residues [active] 795359000605 metal binding site [ion binding]; metal-binding site 795359000606 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 795359000607 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 795359000608 NeuB family; Region: NeuB; cl00496 795359000609 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 795359000610 conserved cys residue [active] 795359000611 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 795359000612 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 795359000613 active site 795359000614 substrate binding site [chemical binding]; other site 795359000615 metal binding site [ion binding]; metal-binding site 795359000616 Protein of unknown function (DUF721); Region: DUF721; cl02324 795359000617 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 795359000618 Zn2+ binding site [ion binding]; other site 795359000619 Mg2+ binding site [ion binding]; other site 795359000620 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 795359000621 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 795359000622 NAD(P) binding site [chemical binding]; other site 795359000623 dimer interface [polypeptide binding]; other site 795359000624 tetramer (dimer of dimers) interface [polypeptide binding]; other site 795359000625 substrate binding site [chemical binding]; other site 795359000626 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 795359000627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 795359000628 ATP binding site [chemical binding]; other site 795359000629 Mg2+ binding site [ion binding]; other site 795359000630 G-X-G motif; other site 795359000631 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 795359000632 ATP binding site [chemical binding]; other site 795359000633 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 795359000634 IPP transferase; Region: IPPT; cl00403 795359000635 hypothetical protein; Provisional; Region: PRK11820 795359000636 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 795359000637 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 795359000638 UbiA prenyltransferase family; Region: UbiA; cl00337 795359000639 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 795359000640 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 795359000641 P-loop; other site 795359000642 Magnesium ion binding site [ion binding]; other site 795359000643 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 795359000644 Magnesium ion binding site [ion binding]; other site 795359000645 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 795359000646 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 795359000647 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 795359000648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 795359000649 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 795359000650 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 795359000651 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 795359000652 Protein export membrane protein; Region: SecD_SecF; cl14618 795359000653 NodT family; Region: outer_NodT; TIGR01845 795359000654 Outer membrane efflux protein; Region: OEP; pfam02321 795359000655 Outer membrane efflux protein; Region: OEP; pfam02321 795359000656 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 795359000657 spermidine synthase; Provisional; Region: PRK00811 795359000658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 795359000659 S-adenosylmethionine binding site [chemical binding]; other site 795359000660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359000661 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 795359000662 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 795359000663 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 795359000664 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 795359000665 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 795359000666 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 795359000667 catalytic residue [active] 795359000668 reverse gyrase; Reviewed; Region: PRK09401 795359000669 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 795359000670 ATP binding site [chemical binding]; other site 795359000671 putative Mg++ binding site [ion binding]; other site 795359000672 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 795359000673 active site 795359000674 metal binding site [ion binding]; metal-binding site 795359000675 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 795359000676 domain I; other site 795359000677 DNA binding groove [nucleotide binding] 795359000678 phosphate binding site [ion binding]; other site 795359000679 domain II; other site 795359000680 domain III; other site 795359000681 nucleotide binding site [chemical binding]; other site 795359000682 catalytic site [active] 795359000683 domain IV; other site 795359000684 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 795359000685 Transglycosylase; Region: Transgly; cl07896 795359000686 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 795359000687 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 795359000688 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605 795359000689 octamerization interface [polypeptide binding]; other site 795359000690 diferric-oxygen binding site [ion binding]; other site 795359000691 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 795359000692 metal binding site [ion binding]; metal-binding site 795359000693 active site 795359000694 I-site; other site 795359000695 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 795359000696 putative cation:proton antiport protein; Provisional; Region: PRK10669 795359000697 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 795359000698 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 795359000699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359000700 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 795359000701 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 795359000702 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 795359000703 homotrimer interaction site [polypeptide binding]; other site 795359000704 zinc binding site [ion binding]; other site 795359000705 CDP-binding sites; other site 795359000706 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 795359000707 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 795359000708 putative NAD(P) binding site [chemical binding]; other site 795359000709 putative substrate binding site [chemical binding]; other site 795359000710 catalytic Zn binding site [ion binding]; other site 795359000711 structural Zn binding site [ion binding]; other site 795359000712 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 795359000713 dimer interface [polypeptide binding]; other site 795359000714 ssDNA binding site [nucleotide binding]; other site 795359000715 tetramer (dimer of dimers) interface [polypeptide binding]; other site 795359000716 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 795359000717 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 795359000718 tRNA; other site 795359000719 putative tRNA binding site [nucleotide binding]; other site 795359000720 putative NADP binding site [chemical binding]; other site 795359000721 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 795359000722 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 795359000723 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 795359000724 Ligand Binding Site [chemical binding]; other site 795359000725 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 795359000726 Radical SAM; Region: Elp3; smart00729 795359000727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359000728 FeS/SAM binding site; other site 795359000729 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as...; Region: Mth938-like; cl00182 795359000730 peptide chain release factor 1; Validated; Region: prfA; PRK00591 795359000731 RF-1 domain; Region: RF-1; cl02875 795359000732 RF-1 domain; Region: RF-1; cl02875 795359000733 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 795359000734 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 795359000735 putative trimer interface [polypeptide binding]; other site 795359000736 putative CoA binding site [chemical binding]; other site 795359000737 PPIC-type PPIASE domain; Region: Rotamase; cl08278 795359000738 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 795359000739 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 795359000740 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 795359000741 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 795359000742 protein binding site [polypeptide binding]; other site 795359000743 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 795359000744 SurA N-terminal domain; Region: SurA_N; pfam09312 795359000745 PPIC-type PPIASE domain; Region: Rotamase; cl08278 795359000746 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 795359000747 Recombination protein O N terminal; Region: RecO_N; pfam11967 795359000748 Recombination protein O C terminal; Region: RecO_C; pfam02565 795359000749 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 795359000750 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 795359000751 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 795359000752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359000753 dihydroorotase; Validated; Region: pyrC; PRK09357 795359000754 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 795359000755 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 795359000756 active site 795359000757 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 795359000758 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 795359000759 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 795359000760 cysteine synthases; Region: cysKM; TIGR01136 795359000761 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 795359000762 dimer interface [polypeptide binding]; other site 795359000763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 795359000764 catalytic residue [active] 795359000765 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 795359000766 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 795359000767 active site 795359000768 HIGH motif; other site 795359000769 nucleotide binding site [chemical binding]; other site 795359000770 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 795359000771 KMSKS motif; other site 795359000772 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 795359000773 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 795359000774 minor groove reading motif; other site 795359000775 helix-hairpin-helix signature motif; other site 795359000776 substrate binding pocket [chemical binding]; other site 795359000777 active site 795359000778 EamA-like transporter family; Region: EamA; cl01037 795359000779 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 795359000780 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 795359000781 homodimer interface [polypeptide binding]; other site 795359000782 Walker A motif; other site 795359000783 ATP binding site [chemical binding]; other site 795359000784 hydroxycobalamin binding site [chemical binding]; other site 795359000785 Walker B motif; other site 795359000786 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 795359000787 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 795359000788 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 795359000789 active site 795359000790 Putative periplasminc binding protein (DUF178); Region: DUF178; cl15271 795359000791 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 795359000792 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 795359000793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 795359000794 S-adenosylmethionine binding site [chemical binding]; other site 795359000795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359000796 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 795359000797 metal binding site [ion binding]; metal-binding site 795359000798 active site 795359000799 I-site; other site 795359000800 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 795359000801 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359000802 FeS/SAM binding site; other site 795359000803 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 795359000804 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 795359000805 YtxH-like protein; Region: YtxH; cl02079 795359000806 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 795359000807 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 795359000808 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 795359000809 Glycogen synthase [Carbohydrate transport and metabolism]; Region: GlgA; COG0297 795359000810 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 795359000811 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 795359000812 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 795359000813 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 795359000814 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 795359000815 GTP-binding protein YchF; Reviewed; Region: PRK09601 795359000816 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 795359000817 G1 box; other site 795359000818 GTP/Mg2+ binding site [chemical binding]; other site 795359000819 Switch I region; other site 795359000820 G2 box; other site 795359000821 Switch II region; other site 795359000822 G3 box; other site 795359000823 G4 box; other site 795359000824 G5 box; other site 795359000825 GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information on the function of the TGS domain, but...; Region: TGS; cl03735 795359000826 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 795359000827 active site 795359000828 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 795359000829 ThiC family; Region: ThiC; cl08031 795359000830 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 795359000831 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 795359000832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 795359000833 putative substrate translocation pore; other site 795359000834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 795359000835 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 795359000836 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 795359000837 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cl00358 795359000838 dimerization interface [polypeptide binding]; other site 795359000839 active site 795359000840 PilZ domain; Region: PilZ; cl01260 795359000841 DsrE/DsrF-like family; Region: DrsE; cl00672 795359000842 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 795359000843 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 795359000844 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 795359000845 active site 795359000846 dimer interface [polypeptide binding]; other site 795359000847 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 795359000848 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 795359000849 dimer interface [polypeptide binding]; other site 795359000850 active site 795359000851 Schiff base residues; other site 795359000852 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 795359000853 Sporulation related domain; Region: SPOR; cl10051 795359000854 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 795359000855 dimerization interface [polypeptide binding]; other site 795359000856 active site 795359000857 metal binding site [ion binding]; metal-binding site 795359000858 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 795359000859 GTPase Era; Reviewed; Region: era; PRK00089 795359000860 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 795359000861 G1 box; other site 795359000862 GTP/Mg2+ binding site [chemical binding]; other site 795359000863 Switch I region; other site 795359000864 G2 box; other site 795359000865 Switch II region; other site 795359000866 G3 box; other site 795359000867 G4 box; other site 795359000868 G5 box; other site 795359000869 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 795359000870 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 795359000871 active site 795359000872 catalytic triad [active] 795359000873 dimer interface [polypeptide binding]; other site 795359000874 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 795359000875 active site 795359000876 nucleotide binding site [chemical binding]; other site 795359000877 HIGH motif; other site 795359000878 KMSKS motif; other site 795359000879 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 795359000880 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 795359000881 M28, and M42; Region: Zinc_peptidase_like; cl14876 795359000882 peptidase T-like protein; Region: PepT-like; TIGR01883 795359000883 metal binding site [ion binding]; metal-binding site 795359000884 Acylphosphatase; Region: Acylphosphatase; cl00551 795359000885 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 795359000886 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 795359000887 ATP binding site [chemical binding]; other site 795359000888 dimerization interface [polypeptide binding]; other site 795359000889 Metal binding site [ion binding]; metal-binding site 795359000890 16S rRNA methyltransferase B; Provisional; Region: PRK14902 795359000891 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 795359000892 putative RNA binding site [nucleotide binding]; other site 795359000893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359000894 excinuclease ABC subunit B; Provisional; Region: PRK05298 795359000895 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 795359000896 ATP binding site [chemical binding]; other site 795359000897 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 795359000898 nucleotide binding region [chemical binding]; other site 795359000899 ATP-binding site [chemical binding]; other site 795359000900 Ultra-violet resistance protein B; Region: UvrB; pfam12344 795359000901 UvrB/uvrC motif; Region: UVR; pfam02151 795359000902 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 795359000903 diiron binding motif [ion binding]; other site 795359000904 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 795359000905 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 795359000906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359000907 FeS/SAM binding site; other site 795359000908 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 795359000909 thiamine phosphate binding site [chemical binding]; other site 795359000910 active site 795359000911 pyrophosphate binding site [ion binding]; other site 795359000912 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 795359000913 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 795359000914 ligand binding site [chemical binding]; other site 795359000915 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 795359000916 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 795359000917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359000918 active site 795359000919 phosphorylation site [posttranslational modification] 795359000920 intermolecular recognition site; other site 795359000921 dimerization interface [polypeptide binding]; other site 795359000922 Response regulator receiver domain; Region: Response_reg; pfam00072 795359000923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359000924 active site 795359000925 phosphorylation site [posttranslational modification] 795359000926 intermolecular recognition site; other site 795359000927 dimerization interface [polypeptide binding]; other site 795359000928 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 795359000929 metal binding site [ion binding]; metal-binding site 795359000930 active site 795359000931 I-site; other site 795359000932 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 795359000933 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 795359000934 Substrate binding site [chemical binding]; other site 795359000935 Cupin domain; Region: Cupin_2; cl09118 795359000936 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 795359000937 active site 795359000938 NTP binding site [chemical binding]; other site 795359000939 metal binding triad [ion binding]; metal-binding site 795359000940 antibiotic binding site [chemical binding]; other site 795359000941 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 795359000942 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 795359000943 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 795359000944 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 795359000945 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 795359000946 MatE; Region: MatE; cl10513 795359000947 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 795359000948 UDP-galactopyranose mutase; Region: UDP-GALP_mutase; TIGR00031 795359000949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359000950 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 795359000951 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 795359000952 Probable Catalytic site [active] 795359000953 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 795359000954 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 795359000955 Ligand binding site [chemical binding]; other site 795359000956 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 795359000957 active site 795359000958 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 795359000959 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 795359000960 active site 795359000961 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 795359000962 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 795359000963 active site 795359000964 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 795359000965 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 795359000966 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 795359000967 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 795359000968 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_4; cd03795 795359000969 putative ADP-binding pocket [chemical binding]; other site 795359000970 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 795359000971 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 795359000972 substrate binding site [chemical binding]; other site 795359000973 tetramer interface [polypeptide binding]; other site 795359000974 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 795359000975 YcfA-like protein; Region: YcfA; cl00752 795359000976 Cupin domain; Region: Cupin_2; cl09118 795359000977 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 795359000978 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 795359000979 NAD binding site [chemical binding]; other site 795359000980 substrate binding site [chemical binding]; other site 795359000981 homodimer interface [polypeptide binding]; other site 795359000982 active site 795359000983 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 795359000984 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 795359000985 NADP binding site [chemical binding]; other site 795359000986 active site 795359000987 putative substrate binding site [chemical binding]; other site 795359000988 FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 795359000989 putative active site [active] 795359000990 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 795359000991 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 795359000992 Bacterial sugar transferase; Region: Bac_transf; cl00939 795359000993 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 795359000994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359000995 Chain length determinant protein; Region: Wzz; cl01623 795359000996 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 795359000997 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 795359000998 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 795359000999 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 795359001000 SLBB domain; Region: SLBB; pfam10531 795359001001 SLBB domain; Region: SLBB; pfam10531 795359001002 SLBB-domain like (DUF1017); Region: DUF1017; pfam06251 795359001003 Protein of unknown function (DUF429); Region: DUF429; cl12046 795359001004 rod shape-determining protein MreB; Provisional; Region: PRK13927 795359001005 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 795359001006 ATP binding site [chemical binding]; other site 795359001007 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 795359001008 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 795359001009 catalytic center binding site [active] 795359001010 ATP binding site [chemical binding]; other site 795359001011 aspartate aminotransferase; Provisional; Region: PRK07681 795359001012 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 795359001013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 795359001014 homodimer interface [polypeptide binding]; other site 795359001015 catalytic residue [active] 795359001016 Myo-inositol-1-phosphate synthase; Region: Inos-1-P_synth; cl00554 795359001017 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 795359001018 DNA gyrase subunit A; Validated; Region: PRK05560 795359001019 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 795359001020 CAP-like domain; other site 795359001021 Active site [active] 795359001022 primary dimer interface [polypeptide binding]; other site 795359001023 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 795359001024 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 795359001025 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 795359001026 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 795359001027 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 795359001028 putative acyl-acceptor binding pocket; other site 795359001029 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 795359001030 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 795359001031 glutamine binding [chemical binding]; other site 795359001032 catalytic triad [active] 795359001033 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 795359001034 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 795359001035 chorismate binding enzyme; Region: Chorismate_bind; cl10555 795359001036 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 795359001037 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 795359001038 dimer interface [polypeptide binding]; other site 795359001039 motif 1; other site 795359001040 active site 795359001041 motif 2; other site 795359001042 motif 3; other site 795359001043 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 795359001044 anticodon binding site; other site 795359001045 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 795359001046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359001047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359001048 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 795359001049 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 795359001050 active site residue [active] 795359001051 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 795359001052 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 795359001053 G1 box; other site 795359001054 GTP/Mg2+ binding site [chemical binding]; other site 795359001055 Switch I region; other site 795359001056 G2 box; other site 795359001057 G3 box; other site 795359001058 Switch II region; other site 795359001059 G4 box; other site 795359001060 G5 box; other site 795359001061 Nucleoside recognition; Region: Gate; cl00486 795359001062 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 795359001063 Nucleoside recognition; Region: Gate; cl00486 795359001064 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 795359001065 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 795359001066 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 795359001067 active site 795359001068 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221 795359001069 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 795359001070 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 795359001071 4Fe-4S binding domain; Region: Fer4; cl02805 795359001072 Uncharacterized conserved protein [Function unknown]; Region: COG3945 795359001073 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 795359001074 Protein of unknown function (DUF996); Region: DUF996; cl00970 795359001075 Flagellin N-methylase; Region: FliB; cl00497 795359001076 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 795359001077 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 795359001078 Predicted methyltransferases [General function prediction only]; Region: COG0313 795359001079 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 795359001080 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 795359001081 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 795359001082 N-terminal plug; other site 795359001083 ligand-binding site [chemical binding]; other site 795359001084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 795359001085 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 795359001086 Putative Fe-S cluster; Region: FeS; pfam04060 795359001087 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 795359001088 substrate binding pocket [chemical binding]; other site 795359001089 dimer interface [polypeptide binding]; other site 795359001090 inhibitor binding site; inhibition site 795359001091 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 795359001092 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 795359001093 metal cluster binding site [ion binding]; other site 795359001094 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; cl11685 795359001095 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 795359001096 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 795359001097 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 795359001098 FAD binding site [chemical binding]; other site 795359001099 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 795359001100 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 795359001101 Prismane/CO dehydrogenase family; Region: Prismane; pfam03063 795359001102 ACS interaction site; other site 795359001103 CODH interaction site; other site 795359001104 metal cluster binding site [ion binding]; other site 795359001105 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 795359001106 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 795359001107 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 795359001108 homodimer interface [polypeptide binding]; other site 795359001109 NADP binding site [chemical binding]; other site 795359001110 substrate binding site [chemical binding]; other site 795359001111 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 795359001112 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 795359001113 Potassium binding sites [ion binding]; other site 795359001114 Cesium cation binding sites [ion binding]; other site 795359001115 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 795359001116 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 795359001117 NAD binding site [chemical binding]; other site 795359001118 homodimer interface [polypeptide binding]; other site 795359001119 active site 795359001120 substrate binding site [chemical binding]; other site 795359001121 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 795359001122 DHH family; Region: DHH; pfam01368 795359001123 DHHA1 domain; Region: DHHA1; pfam02272 795359001124 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 795359001125 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 795359001126 Zn2+ binding site [ion binding]; other site 795359001127 Mg2+ binding site [ion binding]; other site 795359001128 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 795359001129 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 795359001130 active site 795359001131 cosubstrate binding site; other site 795359001132 substrate binding site [chemical binding]; other site 795359001133 catalytic site [active] 795359001134 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 795359001135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359001136 binding surface 795359001137 TPR motif; other site 795359001138 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 795359001139 Ligand Binding Site [chemical binding]; other site 795359001140 Isochorismatase family; Region: Isochorismatase; pfam00857 795359001141 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 795359001142 catalytic triad [active] 795359001143 conserved cis-peptide bond; other site 795359001144 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 795359001145 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 795359001146 active site 795359001147 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 795359001148 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 795359001149 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 795359001150 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 795359001151 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 795359001152 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 795359001153 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 795359001154 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 795359001155 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 795359001156 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 795359001157 ligand binding site [chemical binding]; other site 795359001158 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1689 795359001159 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 795359001160 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 795359001161 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 795359001162 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 795359001163 P loop; other site 795359001164 GTP binding site [chemical binding]; other site 795359001165 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 795359001166 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 795359001167 Acylphosphatase; Region: Acylphosphatase; cl00551 795359001168 HypF finger; Region: zf-HYPF; pfam07503 795359001169 HypF finger; Region: zf-HYPF; pfam07503 795359001170 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 795359001171 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 795359001172 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 795359001173 putative active site [active] 795359001174 putative metal binding site [ion binding]; other site 795359001175 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 795359001176 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 795359001177 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 795359001178 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 795359001179 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359001180 FeS/SAM binding site; other site 795359001181 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 795359001182 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 795359001183 Flavoprotein; Region: Flavoprotein; cl08021 795359001184 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 795359001185 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 795359001186 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 795359001187 metal binding site [ion binding]; metal-binding site 795359001188 active site 795359001189 I-site; other site 795359001190 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 795359001191 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 795359001192 putative catalytic cysteine [active] 795359001193 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 795359001194 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 795359001195 active site 795359001196 (T/H)XGH motif; other site 795359001197 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 795359001198 MutS domain I; Region: MutS_I; pfam01624 795359001199 MutS domain II; Region: MutS_II; pfam05188 795359001200 MutS family domain IV; Region: MutS_IV; pfam05190 795359001201 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 795359001202 Walker A/P-loop; other site 795359001203 ATP binding site [chemical binding]; other site 795359001204 Q-loop/lid; other site 795359001205 ABC transporter signature motif; other site 795359001206 Walker B; other site 795359001207 D-loop; other site 795359001208 H-loop/switch region; other site 795359001209 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 795359001210 putative peptidoglycan binding site; other site 795359001211 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 795359001212 putative peptidoglycan binding site; other site 795359001213 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 795359001214 putative peptidoglycan binding site; other site 795359001215 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 795359001216 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 795359001217 active site 795359001218 metal binding site [ion binding]; metal-binding site 795359001219 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 795359001220 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 795359001221 DHH family; Region: DHH; pfam01368 795359001222 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 795359001223 GTP1/OBG; Region: GTP1_OBG; pfam01018 795359001224 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 795359001225 G1 box; other site 795359001226 GTP/Mg2+ binding site [chemical binding]; other site 795359001227 Switch I region; other site 795359001228 G2 box; other site 795359001229 G3 box; other site 795359001230 Switch II region; other site 795359001231 G4 box; other site 795359001232 G5 box; other site 795359001233 gamma-glutamyl kinase; Provisional; Region: PRK05429 795359001234 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 795359001235 nucleotide binding site [chemical binding]; other site 795359001236 homotetrameric interface [polypeptide binding]; other site 795359001237 putative phosphate binding site [ion binding]; other site 795359001238 putative allosteric binding site; other site 795359001239 PUA domain; Region: PUA; cl00607 795359001240 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 795359001241 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 795359001242 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 795359001243 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 795359001244 generic binding surface I; other site 795359001245 generic binding surface II; other site 795359001246 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 795359001247 diiron binding motif [ion binding]; other site 795359001248 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 795359001249 OstA-like protein; Region: OstA; cl00844 795359001250 Organic solvent tolerance protein; Region: OstA_C; pfam04453 795359001251 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 795359001252 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 795359001253 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 795359001254 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 795359001255 Outer membrane efflux protein; Region: OEP; pfam02321 795359001256 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 795359001257 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 795359001258 Walker A/P-loop; other site 795359001259 ATP binding site [chemical binding]; other site 795359001260 Q-loop/lid; other site 795359001261 ABC transporter signature motif; other site 795359001262 Walker B; other site 795359001263 D-loop; other site 795359001264 H-loop/switch region; other site 795359001265 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359001266 Walker A/P-loop; other site 795359001267 ATP binding site [chemical binding]; other site 795359001268 Q-loop/lid; other site 795359001269 ABC transporter signature motif; other site 795359001270 Walker B; other site 795359001271 D-loop; other site 795359001272 H-loop/switch region; other site 795359001273 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 795359001274 ABC-2 type transporter; Region: ABC2_membrane; cl11417 795359001275 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 795359001276 ABC-2 type transporter; Region: ABC2_membrane; cl11417 795359001277 Domain of unknown function (DUF369); Region: DUF369; cl00950 795359001278 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 795359001279 CoenzymeA binding site [chemical binding]; other site 795359001280 subunit interaction site [polypeptide binding]; other site 795359001281 PHB binding site; other site 795359001282 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 795359001283 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 795359001284 catalytic core [active] 795359001285 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 795359001286 Peptidase family M48; Region: Peptidase_M48; cl12018 795359001287 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 795359001288 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 795359001289 tryptophan synthase, beta chain; Region: PLN02618 795359001290 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 795359001291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 795359001292 catalytic residue [active] 795359001293 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 795359001294 substrate binding site [chemical binding]; other site 795359001295 active site 795359001296 catalytic residues [active] 795359001297 heterodimer interface [polypeptide binding]; other site 795359001298 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 795359001299 active site 795359001300 dimer interface [polypeptide binding]; other site 795359001301 metal binding site [ion binding]; metal-binding site 795359001302 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 795359001303 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 795359001304 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 795359001305 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 795359001306 dihydrodipicolinate synthase; Region: dapA; TIGR00674 795359001307 dimer interface [polypeptide binding]; other site 795359001308 active site 795359001309 catalytic residue [active] 795359001310 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 795359001311 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 795359001312 dimer interface [polypeptide binding]; other site 795359001313 active site 795359001314 metal binding site [ion binding]; metal-binding site 795359001315 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 795359001316 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 795359001317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359001318 active site 795359001319 phosphorylation site [posttranslational modification] 795359001320 intermolecular recognition site; other site 795359001321 dimerization interface [polypeptide binding]; other site 795359001322 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 795359001323 DNA binding site [nucleotide binding] 795359001324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 795359001325 dimer interface [polypeptide binding]; other site 795359001326 phosphorylation site [posttranslational modification] 795359001327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 795359001328 ATP binding site [chemical binding]; other site 795359001329 Mg2+ binding site [ion binding]; other site 795359001330 G-X-G motif; other site 795359001331 PAS fold; Region: PAS; pfam00989 795359001332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 795359001333 putative active site [active] 795359001334 heme pocket [chemical binding]; other site 795359001335 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 795359001336 metal binding site [ion binding]; metal-binding site 795359001337 active site 795359001338 I-site; other site 795359001339 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 795359001340 Uncharacterized ACR, COG1469; Region: DUF198; cl00642 795359001341 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 795359001342 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 795359001343 dimerization interface [polypeptide binding]; other site 795359001344 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 795359001345 ATP binding site [chemical binding]; other site 795359001346 Hydrogenase expression/synthesis hypA family; Region: HypA; cl00418 795359001347 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 795359001348 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase...; Region: H2MP_MemB-H2up; cd06062 795359001349 putative substrate-binding site; other site 795359001350 nickel binding site [ion binding]; other site 795359001351 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 795359001352 Ligand Binding Site [chemical binding]; other site 795359001353 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 795359001354 Ligand Binding Site [chemical binding]; other site 795359001355 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 795359001356 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 795359001357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 795359001358 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 795359001359 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 795359001360 FOG: CBS domain [General function prediction only]; Region: COG0517 795359001361 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 795359001362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 795359001363 metal binding site [ion binding]; metal-binding site 795359001364 active site 795359001365 I-site; other site 795359001366 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 795359001367 nucleoside/Zn binding site; other site 795359001368 dimer interface [polypeptide binding]; other site 795359001369 catalytic motif [active] 795359001370 LytB protein; Region: LYTB; cl00507 795359001371 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 795359001372 hypothetical protein; Reviewed; Region: PRK00024 795359001373 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 795359001374 MPN+ (JAMM) motif; other site 795359001375 Zinc-binding site [ion binding]; other site 795359001376 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 795359001377 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 795359001378 NeuB family; Region: NeuB; cl00496 795359001379 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 795359001380 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 795359001381 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 795359001382 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 795359001383 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose...; Region: GT1_Trehalose_phosphorylase; cd03792 795359001384 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 795359001385 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 795359001386 active site 795359001387 homotetramer interface [polypeptide binding]; other site 795359001388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 795359001389 Domain of unknown function DUF77; Region: DUF77; cl00307 795359001390 argininosuccinate synthase; Provisional; Region: PLN00200 795359001391 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 795359001392 ANP binding site [chemical binding]; other site 795359001393 Substrate Binding Site II [chemical binding]; other site 795359001394 Substrate Binding Site I [chemical binding]; other site 795359001395 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 795359001396 active site 795359001397 intersubunit interactions; other site 795359001398 catalytic residue [active] 795359001399 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 795359001400 active site 795359001401 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 795359001402 DNA repair protein RadA; Provisional; Region: PRK11823 795359001403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359001404 Walker A motif; other site 795359001405 ATP binding site [chemical binding]; other site 795359001406 Walker B motif; other site 795359001407 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 795359001408 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 795359001409 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 795359001410 substrate binding site [chemical binding]; other site 795359001411 glutamase interaction surface [polypeptide binding]; other site 795359001412 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 795359001413 NAD-dependent deacetylase; Provisional; Region: PRK14138 795359001414 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2-fam; cd01407 795359001415 NAD+ binding site [chemical binding]; other site 795359001416 substrate binding site [chemical binding]; other site 795359001417 Zn binding site [ion binding]; other site 795359001418 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 795359001419 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 795359001420 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 795359001421 dimer interface [polypeptide binding]; other site 795359001422 putative functional site; other site 795359001423 putative MPT binding site; other site 795359001424 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 795359001425 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 795359001426 [4Fe-4S] binding site [ion binding]; other site 795359001427 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 795359001428 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 795359001429 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 795359001430 molybdopterin cofactor binding site; other site 795359001431 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 795359001432 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564; cl11689 795359001433 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 795359001434 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 795359001435 dimer interface [polypeptide binding]; other site 795359001436 putative functional site; other site 795359001437 putative MPT binding site; other site 795359001438 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 795359001439 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 795359001440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359001441 binding surface 795359001442 TPR motif; other site 795359001443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359001444 binding surface 795359001445 TPR motif; other site 795359001446 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 795359001447 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 795359001448 homodimer interface [polypeptide binding]; other site 795359001449 substrate-cofactor binding pocket; other site 795359001450 catalytic residue [active] 795359001451 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 795359001452 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 795359001453 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 795359001454 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359001455 FeS/SAM binding site; other site 795359001456 putative glycosyl transferase; Provisional; Region: PRK10073 795359001457 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 795359001458 active site 795359001459 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 795359001460 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 795359001461 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 795359001462 Ligand Binding Site [chemical binding]; other site 795359001463 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 795359001464 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (; Region: GT1_wlbH_like; cd03798 795359001465 O-Antigen ligase; Region: Wzy_C; cl04850 795359001466 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 795359001467 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 795359001468 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 795359001469 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 795359001470 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 795359001471 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 795359001472 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 795359001473 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 795359001474 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 795359001475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 795359001476 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 795359001477 Ligand Binding Site [chemical binding]; other site 795359001478 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 795359001479 MoaE homodimer interface [polypeptide binding]; other site 795359001480 MoaD interaction [polypeptide binding]; other site 795359001481 active site residues [active] 795359001482 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 795359001483 metal binding site 2 [ion binding]; metal-binding site 795359001484 putative DNA binding helix; other site 795359001485 metal binding site 1 [ion binding]; metal-binding site 795359001486 dimer interface [polypeptide binding]; other site 795359001487 structural Zn2+ binding site [ion binding]; other site 795359001488 FeoA domain; Region: FeoA; cl00838 795359001489 PilZ domain; Region: PilZ; cl01260 795359001490 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 795359001491 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 795359001492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 795359001493 dimer interface [polypeptide binding]; other site 795359001494 conserved gate region; other site 795359001495 putative PBP binding loops; other site 795359001496 ABC-ATPase subunit interface; other site 795359001497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 795359001498 dimer interface [polypeptide binding]; other site 795359001499 conserved gate region; other site 795359001500 putative PBP binding loops; other site 795359001501 ABC-ATPase subunit interface; other site 795359001502 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 795359001503 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 795359001504 Walker A/P-loop; other site 795359001505 ATP binding site [chemical binding]; other site 795359001506 Q-loop/lid; other site 795359001507 ABC transporter signature motif; other site 795359001508 Walker B; other site 795359001509 D-loop; other site 795359001510 H-loop/switch region; other site 795359001511 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 795359001512 heterotetramer interface [polypeptide binding]; other site 795359001513 active site pocket [active] 795359001514 cleavage site 795359001515 Survival protein SurE; Region: SurE; cl00448 795359001516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 795359001517 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 795359001518 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 795359001519 active site 795359001520 Riboflavin kinase; Region: Flavokinase; cl03312 795359001521 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 795359001522 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 795359001523 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 795359001524 catalytic site [active] 795359001525 subunit interface [polypeptide binding]; other site 795359001526 peptide chain release factor 2; Validated; Region: prfB; PRK00578 795359001527 RF-1 domain; Region: RF-1; cl02875 795359001528 RF-1 domain; Region: RF-1; cl02875 795359001529 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 795359001530 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 795359001531 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 795359001532 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 795359001533 Rubredoxin; Region: Rubredoxin; pfam00301 795359001534 iron binding site [ion binding]; other site 795359001535 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 795359001536 Rubredoxin; Region: Rubredoxin; pfam00301 795359001537 iron binding site [ion binding]; other site 795359001538 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 795359001539 Rubredoxin; Region: Rubredoxin; pfam00301 795359001540 iron binding site [ion binding]; other site 795359001541 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 795359001542 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small...; Region: DSRD; cd00974 795359001543 non-heme iron binding site [ion binding]; other site 795359001544 dimer interface [polypeptide binding]; other site 795359001545 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion...; Region: SORL_Dfx_classI; cd03171 795359001546 non-heme iron binding site [ion binding]; other site 795359001547 dimer interface [polypeptide binding]; other site 795359001548 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 795359001549 DNA binding residues [nucleotide binding] 795359001550 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 795359001551 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 795359001552 putative tRNA-binding site [nucleotide binding]; other site 795359001553 B3/4 domain; Region: B3_4; cl11458 795359001554 tRNA synthetase B5 domain; Region: B5; cl08394 795359001555 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 795359001556 dimer interface [polypeptide binding]; other site 795359001557 motif 1; other site 795359001558 motif 3; other site 795359001559 motif 2; other site 795359001560 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 795359001561 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 795359001562 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 795359001563 dimer interface [polypeptide binding]; other site 795359001564 motif 1; other site 795359001565 active site 795359001566 motif 2; other site 795359001567 motif 3; other site 795359001568 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 795359001569 23S rRNA binding site [nucleotide binding]; other site 795359001570 L21 binding site [polypeptide binding]; other site 795359001571 L13 binding site [polypeptide binding]; other site 795359001572 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 795359001573 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 795359001574 active site 795359001575 oligomerization interface [polypeptide binding]; other site 795359001576 metal binding site [ion binding]; metal-binding site 795359001577 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 795359001578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359001579 Walker A motif; other site 795359001580 ATP binding site [chemical binding]; other site 795359001581 Walker B motif; other site 795359001582 arginine finger; other site 795359001583 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 795359001584 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 795359001585 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 795359001586 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 795359001587 dimerization interface [polypeptide binding]; other site 795359001588 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 795359001589 G1 box; other site 795359001590 GTP/Mg2+ binding site [chemical binding]; other site 795359001591 Switch I region; other site 795359001592 G2 box; other site 795359001593 G3 box; other site 795359001594 Switch II region; other site 795359001595 G4 box; other site 795359001596 G5 box; other site 795359001597 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 795359001598 peroxiredoxin; Provisional; Region: PRK13189 795359001599 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 795359001600 dimer interface [polypeptide binding]; other site 795359001601 decamer (pentamer of dimers) interface [polypeptide binding]; other site 795359001602 catalytic triad [active] 795359001603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 795359001604 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 795359001605 substrate binding site [chemical binding]; other site 795359001606 ATP binding site [chemical binding]; other site 795359001607 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 795359001608 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 795359001609 amidophosphoribosyltransferase; Region: purF; TIGR01134 795359001610 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 795359001611 active site 795359001612 tetramer interface [polypeptide binding]; other site 795359001613 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 795359001614 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 795359001615 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 795359001616 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 795359001617 active site 795359001618 metal binding site [ion binding]; metal-binding site 795359001619 homotetramer interface [polypeptide binding]; other site 795359001620 prolyl-tRNA synthetase; Provisional; Region: PRK09194 795359001621 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 795359001622 dimer interface [polypeptide binding]; other site 795359001623 motif 1; other site 795359001624 active site 795359001625 motif 2; other site 795359001626 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 795359001627 putative deacylase active site [active] 795359001628 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 795359001629 active site 795359001630 motif 3; other site 795359001631 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 795359001632 anticodon binding site; other site 795359001633 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 795359001634 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 795359001635 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 795359001636 trimer interface [polypeptide binding]; other site 795359001637 active site 795359001638 UDP-GlcNAc binding site [chemical binding]; other site 795359001639 lipid binding site [chemical binding]; lipid-binding site 795359001640 Competence protein A; Region: Competence_A; pfam11104 795359001641 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 795359001642 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 795359001643 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 795359001644 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605 795359001645 hemerythrin-like metal-binding domain; Region: hemeryth_dom; TIGR02481 795359001646 octamerization interface [polypeptide binding]; other site 795359001647 diferric-oxygen binding site [ion binding]; other site 795359001648 Radical SAM; Region: Elp3; smart00729 795359001649 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359001650 FeS/SAM binding site; other site 795359001651 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 795359001652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359001653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 795359001654 Isochorismatase family; Region: Isochorismatase; pfam00857 795359001655 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 795359001656 catalytic triad [active] 795359001657 dimer interface [polypeptide binding]; other site 795359001658 conserved cis-peptide bond; other site 795359001659 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 795359001660 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 795359001661 active site 795359001662 putative DNA-binding cleft [nucleotide binding]; other site 795359001663 dimer interface [polypeptide binding]; other site 795359001664 Domain of unknown function DUF28; Region: DUF28; cl00361 795359001665 putative inner membrane protein; Provisional; Region: PRK11099 795359001666 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 795359001667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359001668 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 795359001669 metal binding site [ion binding]; metal-binding site 795359001670 active site 795359001671 I-site; other site 795359001672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 795359001673 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 795359001674 ATP phosphoribosyltransferase; Region: HisG; cl15266 795359001675 HisG, C-terminal domain; Region: HisG_C; cl06867 795359001676 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 795359001677 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 795359001678 active site 795359001679 ribulose/triose binding site [chemical binding]; other site 795359001680 phosphate binding site [ion binding]; other site 795359001681 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 795359001682 substrate (anthranilate) binding pocket [chemical binding]; other site 795359001683 product (indole) binding pocket [chemical binding]; other site 795359001684 Ribonuclease P; Region: Ribonuclease_P; cl00457 795359001685 Domain of unknown function DUF37; Region: DUF37; cl00506 795359001686 membrane protein insertase; Provisional; Region: PRK01318 795359001687 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 795359001688 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 795359001689 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 795359001690 G-X-X-G motif; other site 795359001691 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 795359001692 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 795359001693 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 795359001694 GTP/Mg2+ binding site [chemical binding]; other site 795359001695 G4 box; other site 795359001696 G5 box; other site 795359001697 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 795359001698 G1 box; other site 795359001699 G1 box; other site 795359001700 GTP/Mg2+ binding site [chemical binding]; other site 795359001701 Switch I region; other site 795359001702 Switch I region; other site 795359001703 G2 box; other site 795359001704 G2 box; other site 795359001705 Switch II region; other site 795359001706 G3 box; other site 795359001707 G3 box; other site 795359001708 Switch II region; other site 795359001709 G4 box; other site 795359001710 G5 box; other site 795359001711 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 795359001712 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 795359001713 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 795359001714 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 795359001715 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 795359001716 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 795359001717 dimer interface [polypeptide binding]; other site 795359001718 substrate binding site [chemical binding]; other site 795359001719 ATP binding site [chemical binding]; other site 795359001720 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 795359001721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 795359001722 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 795359001723 ParB-like nuclease domain; Region: ParBc; cl02129 795359001724 ParB-like partition proteins; Region: parB_part; TIGR00180 795359001725 KorB domain; Region: KorB; pfam08535 795359001726 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a...; Region: GT1_AviGT4_like; cd03802 795359001727 putative ADP-binding pocket [chemical binding]; other site 795359001728 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 795359001729 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 795359001730 DsrE/DsrF-like family; Region: DrsE; cl00672 795359001731 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 795359001732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359001733 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 795359001734 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 795359001735 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 795359001736 peptide binding site [polypeptide binding]; other site 795359001737 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 795359001738 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 795359001739 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 795359001740 competence damage-inducible protein A; Provisional; Region: PRK00549 795359001741 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 795359001742 putative MPT binding site; other site 795359001743 Competence-damaged protein; Region: CinA; cl00666 795359001744 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 795359001745 tetramer interfaces [polypeptide binding]; other site 795359001746 binuclear metal-binding site [ion binding]; other site 795359001747 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 795359001748 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 795359001749 TIGR01777 family protein; Region: yfcH 795359001750 putative NAD(P) binding site [chemical binding]; other site 795359001751 putative active site [active] 795359001752 Ion channel; Region: Ion_trans_2; cl11596 795359001753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359001754 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 795359001755 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 795359001756 Ligand Binding Site [chemical binding]; other site 795359001757 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 795359001758 Ligand Binding Site [chemical binding]; other site 795359001759 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 795359001760 Citrate transporter; Region: CitMHS; pfam03600 795359001761 transmembrane helices; other site 795359001762 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 795359001763 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 795359001764 active site 795359001765 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 795359001766 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 795359001767 generic binding surface II; other site 795359001768 ssDNA binding site; other site 795359001769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 795359001770 ATP binding site [chemical binding]; other site 795359001771 putative Mg++ binding site [ion binding]; other site 795359001772 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 795359001773 nucleotide binding region [chemical binding]; other site 795359001774 ATP-binding site [chemical binding]; other site 795359001775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359001776 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 795359001777 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 795359001778 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 795359001779 minor groove reading motif; other site 795359001780 helix-hairpin-helix signature motif; other site 795359001781 substrate binding pocket [chemical binding]; other site 795359001782 active site 795359001783 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 795359001784 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 795359001785 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 795359001786 motif 1; other site 795359001787 active site 795359001788 motif 2; other site 795359001789 motif 3; other site 795359001790 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 795359001791 DHHA1 domain; Region: DHHA1; pfam02272 795359001792 S-adenosylmethionine synthetase; Validated; Region: PRK05250 795359001793 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 795359001794 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 795359001795 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 795359001796 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 795359001797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359001798 oligomerization interface [polypeptide binding]; other site 795359001799 active site 795359001800 NAD+ binding site [chemical binding]; other site 795359001801 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 795359001802 Lumazine binding domain; Region: Lum_binding; pfam00677 795359001803 Lumazine binding domain; Region: Lum_binding; pfam00677 795359001804 Beta-lactamase; Region: Beta-lactamase; cl01009 795359001805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359001806 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 795359001807 Phosphate transporter family; Region: PHO4; cl00396 795359001808 TIGR00153 family protein; Region: TIGR00153 795359001809 FOG: CBS domain [General function prediction only]; Region: COG0517 795359001810 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 795359001811 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 795359001812 active site 795359001813 dimerization interface [polypeptide binding]; other site 795359001814 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 795359001815 nudix motif; other site 795359001816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 795359001817 active site 795359001818 dimerization interface [polypeptide binding]; other site 795359001819 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 795359001820 metal binding site [ion binding]; metal-binding site 795359001821 active site 795359001822 I-site; other site 795359001823 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 795359001824 RNB domain; Region: RNB; pfam00773 795359001825 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 795359001826 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 795359001827 catalytic residues [active] 795359001828 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 795359001829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359001830 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 795359001831 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 795359001832 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 795359001833 DRTGG domain; Region: DRTGG; cl12147 795359001834 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 795359001835 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 795359001836 active site 795359001837 putative substrate binding pocket [chemical binding]; other site 795359001838 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 795359001839 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 795359001840 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 795359001841 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 795359001842 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 795359001843 dimer interface [polypeptide binding]; other site 795359001844 active site 795359001845 metal binding site [ion binding]; metal-binding site 795359001846 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 795359001847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359001848 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 795359001849 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 795359001850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 795359001851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 795359001852 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 795359001853 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 795359001854 dimer interface [polypeptide binding]; other site 795359001855 PYR/PP interface [polypeptide binding]; other site 795359001856 TPP binding site [chemical binding]; other site 795359001857 substrate binding site [chemical binding]; other site 795359001858 TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the...; Region: TPP_IOR_alpha; cd02008 795359001859 TPP-binding site; other site 795359001860 ACT domain-containing protein [General function prediction only]; Region: COG4747 795359001861 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 795359001862 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 795359001863 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 795359001864 ACT domain-containing protein [General function prediction only]; Region: COG4747 795359001865 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 795359001866 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 795359001867 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 795359001868 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 795359001869 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 795359001870 L-lactate permease; Region: Lactate_perm; cl00701 795359001871 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 795359001872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 795359001873 binding surface 795359001874 TPR motif; other site 795359001875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359001876 binding surface 795359001877 TPR motif; other site 795359001878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359001879 binding surface 795359001880 TPR motif; other site 795359001881 YceG-like family; Region: YceG; pfam02618 795359001882 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 795359001883 dimerization interface [polypeptide binding]; other site 795359001884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359001885 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 795359001886 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 795359001887 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 795359001888 metabolite-proton symporter; Region: 2A0106; TIGR00883 795359001889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 795359001890 putative substrate translocation pore; other site 795359001891 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 795359001892 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 795359001893 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 795359001894 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 795359001895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359001896 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 795359001897 NAD(P) binding site [chemical binding]; other site 795359001898 active site 795359001899 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 795359001900 intersubunit interface [polypeptide binding]; other site 795359001901 active site 795359001902 Zn2+ binding site [ion binding]; other site 795359001903 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 795359001904 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 795359001905 inhibitor-cofactor binding pocket; inhibition site 795359001906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 795359001907 catalytic residue [active] 795359001908 ketol-acid reductoisomerase; Provisional; Region: PRK05479 795359001909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359001910 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 795359001911 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 795359001912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359001913 active site 795359001914 phosphorylation site [posttranslational modification] 795359001915 intermolecular recognition site; other site 795359001916 dimerization interface [polypeptide binding]; other site 795359001917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359001918 Walker A motif; other site 795359001919 ATP binding site [chemical binding]; other site 795359001920 Walker B motif; other site 795359001921 arginine finger; other site 795359001922 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 795359001923 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 795359001924 dimerization interface [polypeptide binding]; other site 795359001925 sensory histidine kinase AtoS; Provisional; Region: PRK11360 795359001926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 795359001927 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 795359001928 active site 795359001929 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 795359001930 putative active site [active] 795359001931 dimerization interface [polypeptide binding]; other site 795359001932 putative tRNAtyr binding site [nucleotide binding]; other site 795359001933 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 795359001934 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 795359001935 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 795359001936 TPP-binding site [chemical binding]; other site 795359001937 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 795359001938 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 795359001939 dimer interface [polypeptide binding]; other site 795359001940 PYR/PP interface [polypeptide binding]; other site 795359001941 TPP binding site [chemical binding]; other site 795359001942 substrate binding site [chemical binding]; other site 795359001943 2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626 795359001944 Acyl transferase domain; Region: Acyl_transf_1; cl08282 795359001945 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 795359001946 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 795359001947 lipoyl attachment site [posttranslational modification]; other site 795359001948 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 795359001949 Fructose-1,6-bisphosphatase; Region: FBPase_3; cl00862 795359001950 Flagellin N-methylase; Region: FliB; cl00497 795359001951 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 795359001952 hypothetical protein; Validated; Region: PRK07682 795359001953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 795359001954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 795359001955 homodimer interface [polypeptide binding]; other site 795359001956 catalytic residue [active] 795359001957 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 795359001958 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 795359001959 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 795359001960 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359001961 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 795359001962 Autotransporter beta-domain; Region: Autotransporter; cl02365 795359001963 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 795359001964 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 795359001965 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 795359001966 active site 795359001967 dimer interface [polypeptide binding]; other site 795359001968 motif 1; other site 795359001969 motif 2; other site 795359001970 motif 3; other site 795359001971 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 795359001972 anticodon binding site; other site 795359001973 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 795359001974 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 795359001975 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 795359001976 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 795359001977 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 795359001978 putative active site [active] 795359001979 oxyanion strand; other site 795359001980 catalytic triad [active] 795359001981 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 795359001982 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 795359001983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359001984 FeS/SAM binding site; other site 795359001985 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 795359001986 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 795359001987 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 795359001988 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 795359001989 substrate binding site [chemical binding]; other site 795359001990 hexamer interface [polypeptide binding]; other site 795359001991 metal binding site [ion binding]; metal-binding site 795359001992 diaminopimelate decarboxylase; Region: lysA; TIGR01048 795359001993 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 795359001994 active site 795359001995 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 795359001996 substrate binding site [chemical binding]; other site 795359001997 catalytic residues [active] 795359001998 dimer interface [polypeptide binding]; other site 795359001999 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 795359002000 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 795359002001 Major Facilitator Superfamily; Region: MFS_1; pfam07690 795359002002 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359002003 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 795359002004 putative phosphate binding site [ion binding]; other site 795359002005 putative catalytic site [active] 795359002006 active site 795359002007 metal binding site A [ion binding]; metal-binding site 795359002008 DNA binding site [nucleotide binding] 795359002009 putative AP binding site [nucleotide binding]; other site 795359002010 putative metal binding site B [ion binding]; other site 795359002011 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 795359002012 ATP cone domain; Region: ATP-cone; pfam03477 795359002013 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 795359002014 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 795359002015 thioester formation/cholesterol transfer; other site 795359002016 protein-splicing catalytic site; other site 795359002017 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 795359002018 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 795359002019 thioester formation/cholesterol transfer; other site 795359002020 protein-splicing catalytic site; other site 795359002021 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 795359002022 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 795359002023 signal recognition particle protein; Provisional; Region: PRK10867 795359002024 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 795359002025 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 795359002026 P loop; other site 795359002027 GTP binding site [chemical binding]; other site 795359002028 Signal peptide binding domain; Region: SRP_SPB; pfam02978 795359002029 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 795359002030 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 795359002031 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 795359002032 RimM N-terminal domain; Region: RimM; pfam01782 795359002033 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 795359002034 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 795359002035 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 795359002036 metal-binding site [ion binding] 795359002037 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 795359002038 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 795359002039 metal-binding site [ion binding] 795359002040 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 795359002041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 795359002042 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 795359002043 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 795359002044 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 795359002045 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 795359002046 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 795359002047 pyruvate carboxylase subunit B; Validated; Region: PRK09282 795359002048 active site 795359002049 catalytic residues [active] 795359002050 metal binding site [ion binding]; metal-binding site 795359002051 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 795359002052 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 795359002053 carboxyltransferase (CT) interaction site; other site 795359002054 biotinylation site [posttranslational modification]; other site 795359002055 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 795359002056 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 795359002057 23S rRNA interface [nucleotide binding]; other site 795359002058 L3 interface [polypeptide binding]; other site 795359002059 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 795359002060 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 795359002061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359002062 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 795359002063 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 795359002064 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 795359002065 dimerization interface 3.5A [polypeptide binding]; other site 795359002066 active site 795359002067 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 795359002068 putative active site pocket [active] 795359002069 4-fold oligomerization interface [polypeptide binding]; other site 795359002070 metal binding residues [ion binding]; metal-binding site 795359002071 3-fold/trimer interface [polypeptide binding]; other site 795359002072 Colicin V production protein; Region: Colicin_V; cl00567 795359002073 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 795359002074 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 795359002075 active site 795359002076 HIGH motif; other site 795359002077 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 795359002078 KMSKS motif; other site 795359002079 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 795359002080 tRNA binding surface [nucleotide binding]; other site 795359002081 anticodon binding site; other site 795359002082 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 795359002083 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 795359002084 P-loop; other site 795359002085 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 795359002086 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 795359002087 active site 795359002088 catalytic residues [active] 795359002089 metal binding site [ion binding]; metal-binding site 795359002090 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 795359002091 aspartate kinase; Reviewed; Region: PRK06635 795359002092 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli (...; Region: AAK_AK-DapG-like; cd04246 795359002093 putative catalytic residues [active] 795359002094 putative nucleotide binding site [chemical binding]; other site 795359002095 putative aspartate binding site [chemical binding]; other site 795359002096 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 795359002097 putative allosteric regulatory site; other site 795359002098 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 795359002099 putative allosteric regulatory residue; other site 795359002100 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 795359002101 HSP70 interaction site [polypeptide binding]; other site 795359002102 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 795359002103 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 795359002104 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 795359002105 N-terminal plug; other site 795359002106 ligand-binding site [chemical binding]; other site 795359002107 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 795359002108 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 795359002109 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670 795359002110 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670 795359002111 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359002112 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 795359002113 Walker A/P-loop; other site 795359002114 ATP binding site [chemical binding]; other site 795359002115 Q-loop/lid; other site 795359002116 ABC transporter signature motif; other site 795359002117 Walker B; other site 795359002118 D-loop; other site 795359002119 H-loop/switch region; other site 795359002120 ABC-2 type transporter; Region: ABC2_membrane; cl11417 795359002121 AMMECR1; Region: AMMECR1; cl00911 795359002122 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 795359002123 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 795359002124 dimerization domain [polypeptide binding]; other site 795359002125 dimer interface [polypeptide binding]; other site 795359002126 catalytic residues [active] 795359002127 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes...; Region: NADPH_oxidoreductase_1; cd02150 795359002128 putative FMN binding site [chemical binding]; other site 795359002129 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 795359002130 spermidine synthase; Provisional; Region: PRK00811 795359002131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359002132 chaperone protein DnaJ; Provisional; Region: PRK14299 795359002133 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 795359002134 HSP70 interaction site [polypeptide binding]; other site 795359002135 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 795359002136 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 795359002137 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 795359002138 catalytic motif [active] 795359002139 Zn binding site [ion binding]; other site 795359002140 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 795359002141 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 795359002142 dimer interface [polypeptide binding]; other site 795359002143 glycine-pyridoxal phosphate binding site [chemical binding]; other site 795359002144 active site 795359002145 folate binding site [chemical binding]; other site 795359002146 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 795359002147 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 795359002148 Ligand binding site [chemical binding]; other site 795359002149 Putative Catalytic site [active] 795359002150 DXD motif; other site 795359002151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 795359002152 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 795359002153 S17 interaction site [polypeptide binding]; other site 795359002154 S8 interaction site; other site 795359002155 16S rRNA interaction site [nucleotide binding]; other site 795359002156 streptomycin interaction site [chemical binding]; other site 795359002157 23S rRNA interaction site [nucleotide binding]; other site 795359002158 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 795359002159 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 795359002160 elongation factor G; Reviewed; Region: PRK00007 795359002161 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 795359002162 G1 box; other site 795359002163 putative GEF interaction site [polypeptide binding]; other site 795359002164 GTP/Mg2+ binding site [chemical binding]; other site 795359002165 Switch I region; other site 795359002166 G2 box; other site 795359002167 G3 box; other site 795359002168 Switch II region; other site 795359002169 G4 box; other site 795359002170 G5 box; other site 795359002171 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 795359002172 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 795359002173 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 795359002174 elongation factor Tu; Reviewed; Region: PRK00049 795359002175 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 795359002176 G1 box; other site 795359002177 GEF interaction site [polypeptide binding]; other site 795359002178 GTP/Mg2+ binding site [chemical binding]; other site 795359002179 Switch I region; other site 795359002180 G2 box; other site 795359002181 G3 box; other site 795359002182 Switch II region; other site 795359002183 G4 box; other site 795359002184 G5 box; other site 795359002185 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 795359002186 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 795359002187 Antibiotic Binding Site [chemical binding]; other site 795359002188 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 795359002189 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 795359002190 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 795359002191 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 795359002192 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 795359002193 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 795359002194 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 795359002195 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 795359002196 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 795359002197 putative translocon binding site; other site 795359002198 protein-rRNA interface [nucleotide binding]; other site 795359002199 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 795359002200 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 795359002201 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 795359002202 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 795359002203 23S rRNA interface [nucleotide binding]; other site 795359002204 5S rRNA interface [nucleotide binding]; other site 795359002205 putative antibiotic binding site [chemical binding]; other site 795359002206 L25 interface [polypeptide binding]; other site 795359002207 L27 interface [polypeptide binding]; other site 795359002208 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 795359002209 23S rRNA interface [nucleotide binding]; other site 795359002210 putative translocon interaction site; other site 795359002211 signal recognition particle (SRP54) interaction site; other site 795359002212 L23 interface [polypeptide binding]; other site 795359002213 trigger factor interaction site; other site 795359002214 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 795359002215 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 795359002216 KOW motif; Region: KOW; cl00354 795359002217 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 795359002218 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 795359002219 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 795359002220 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 795359002221 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 795359002222 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 795359002223 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 795359002224 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 795359002225 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 795359002226 5S rRNA interface [nucleotide binding]; other site 795359002227 L27 interface [polypeptide binding]; other site 795359002228 23S rRNA interface [nucleotide binding]; other site 795359002229 L5 interface [polypeptide binding]; other site 795359002230 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 795359002231 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 795359002232 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 795359002233 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 795359002234 23S rRNA binding site [nucleotide binding]; other site 795359002235 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 795359002236 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 795359002237 SecY translocase; Region: SecY; pfam00344 795359002238 adenylate kinase; Reviewed; Region: adk; PRK00279 795359002239 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 795359002240 AMP-binding site [chemical binding]; other site 795359002241 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 795359002242 methionine aminopeptidase; Reviewed; Region: PRK07281 795359002243 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 795359002244 active site 795359002245 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 795359002246 rRNA binding site [nucleotide binding]; other site 795359002247 predicted 30S ribosome binding site; other site 795359002248 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 795359002249 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 795359002250 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 795359002251 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 795359002252 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 795359002253 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 795359002254 RNA binding surface [nucleotide binding]; other site 795359002255 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 795359002256 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 795359002257 alphaNTD homodimer interface [polypeptide binding]; other site 795359002258 alphaNTD - beta interaction site [polypeptide binding]; other site 795359002259 alphaNTD - beta' interaction site [polypeptide binding]; other site 795359002260 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 795359002261 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 795359002262 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 795359002263 active site 795359002264 NTP binding site [chemical binding]; other site 795359002265 metal binding triad [ion binding]; metal-binding site 795359002266 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 795359002267 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 795359002268 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 795359002269 trigger factor; Region: tig; TIGR00115 795359002270 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 795359002271 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 795359002272 oligomer interface [polypeptide binding]; other site 795359002273 active site residues [active] 795359002274 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 795359002275 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 795359002276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359002277 Walker A motif; other site 795359002278 ATP binding site [chemical binding]; other site 795359002279 Walker B motif; other site 795359002280 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 795359002281 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 795359002282 Found in ATP-dependent protease La (LON); Region: LON; smart00464 795359002283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359002284 Walker A motif; other site 795359002285 ATP binding site [chemical binding]; other site 795359002286 Walker B motif; other site 795359002287 arginine finger; other site 795359002288 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 795359002289 transcription termination factor Rho; Provisional; Region: rho; PRK09376 795359002290 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 795359002291 RNA binding site [nucleotide binding]; other site 795359002292 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 795359002293 multimer interface [polypeptide binding]; other site 795359002294 Walker A motif; other site 795359002295 ATP binding site [chemical binding]; other site 795359002296 Walker B motif; other site 795359002297 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 795359002298 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 795359002299 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 795359002300 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 795359002301 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 795359002302 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 795359002303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 795359002304 dimer interface [polypeptide binding]; other site 795359002305 phosphorylation site [posttranslational modification] 795359002306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 795359002307 ATP binding site [chemical binding]; other site 795359002308 Mg2+ binding site [ion binding]; other site 795359002309 G-X-G motif; other site 795359002310 DNA polymerase I; Provisional; Region: PRK05755 795359002311 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 795359002312 active site 795359002313 metal binding site 1 [ion binding]; metal-binding site 795359002314 putative 5' ssDNA interaction site; other site 795359002315 metal binding site 3; metal-binding site 795359002316 metal binding site 2 [ion binding]; metal-binding site 795359002317 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 795359002318 putative DNA binding site [nucleotide binding]; other site 795359002319 putative metal binding site [ion binding]; other site 795359002320 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 795359002321 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 795359002322 active site 795359002323 DNA binding site [nucleotide binding] 795359002324 catalytic site [active] 795359002325 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 795359002326 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 795359002327 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359002328 Walker A/P-loop; other site 795359002329 ATP binding site [chemical binding]; other site 795359002330 Q-loop/lid; other site 795359002331 ABC transporter signature motif; other site 795359002332 Walker B; other site 795359002333 D-loop; other site 795359002334 H-loop/switch region; other site 795359002335 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 795359002336 Smr domain; Region: Smr; cl02619 795359002337 CHC2 zinc finger; Region: zf-CHC2; cl02597 795359002338 DNA primase; Validated; Region: dnaG; PRK05667 795359002339 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 795359002340 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 795359002341 active site 795359002342 metal binding site [ion binding]; metal-binding site 795359002343 interdomain interaction site; other site 795359002344 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 795359002345 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 795359002346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 795359002347 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 795359002348 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 795359002349 DNA binding residues [nucleotide binding] 795359002350 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 795359002351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 795359002352 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 795359002353 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 795359002354 Peptidase family M48; Region: Peptidase_M48; cl12018 795359002355 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 795359002356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359002357 binding surface 795359002358 TPR motif; other site 795359002359 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 795359002360 catalytic core [active] 795359002361 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 795359002362 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 795359002363 structural tetrad; other site 795359002364 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which...; Region: SERPIN; cd00172 795359002365 reactive center loop; other site 795359002366 Protein of unknown function (DUF541); Region: SIMPL; cl01077 795359002367 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 795359002368 RIP metalloprotease RseP; Region: TIGR00054 795359002369 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 795359002370 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 795359002371 putative active site [active] 795359002372 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 795359002373 dimer interface [polypeptide binding]; other site 795359002374 active site 795359002375 UGMP family protein; Validated; Region: PRK09604 795359002376 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 795359002377 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 795359002378 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 795359002379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359002380 active site 795359002381 phosphorylation site [posttranslational modification] 795359002382 intermolecular recognition site; other site 795359002383 dimerization interface [polypeptide binding]; other site 795359002384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359002385 Walker A motif; other site 795359002386 ATP binding site [chemical binding]; other site 795359002387 Walker B motif; other site 795359002388 arginine finger; other site 795359002389 BioY family; Region: BioY; cl00560 795359002390 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 795359002391 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 795359002392 Arginase family; Region: Arginase; cl00306 795359002393 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 795359002394 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 795359002395 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 795359002396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359002397 FeS/SAM binding site; other site 795359002398 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 795359002399 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 795359002400 active site 795359002401 metal binding site [ion binding]; metal-binding site 795359002402 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 795359002403 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 795359002404 Int/Topo IB signature motif; other site 795359002405 active site 795359002406 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 795359002407 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 795359002408 active site 795359002409 NTP binding site [chemical binding]; other site 795359002410 metal binding triad [ion binding]; metal-binding site 795359002411 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 795359002412 RNA binding site [nucleotide binding]; other site 795359002413 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 795359002414 RNA binding site [nucleotide binding]; other site 795359002415 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 795359002416 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 795359002417 RNA binding site [nucleotide binding]; other site 795359002418 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 795359002419 RNA binding site [nucleotide binding]; other site 795359002420 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 795359002421 tandem repeat interface [polypeptide binding]; other site 795359002422 oligomer interface [polypeptide binding]; other site 795359002423 active site residues [active] 795359002424 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 795359002425 IHF dimer interface [polypeptide binding]; other site 795359002426 IHF - DNA interface [nucleotide binding]; other site 795359002427 exopolyphosphatase; Region: exo_poly_only; TIGR03706 795359002428 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 795359002429 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 795359002430 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 795359002431 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 795359002432 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 795359002433 active site 795359002434 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 795359002435 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 795359002436 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 795359002437 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 795359002438 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 795359002439 Bacitracin resistance protein BacA; Region: BacA; cl00858 795359002440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359002441 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 795359002442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 795359002443 S-adenosylmethionine binding site [chemical binding]; other site 795359002444 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 795359002445 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 795359002446 hinge; other site 795359002447 active site 795359002448 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 795359002449 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359002450 putative major pilin subunit; Provisional; Region: PRK10574 795359002451 Sulfatase; Region: Sulfatase; cl10460 795359002452 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, archaeal form; Region: apgM; TIGR00306 795359002453 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 795359002454 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 795359002455 Gram-negative bacterial tonB protein; Region: TonB; cl10048 795359002456 CGGC domain; Region: CGGC; cl02356 795359002457 Protein of unknown function, DUF488; Region: DUF488; cl01246 795359002458 Flavin Reductases; Region: FlaRed; cl00801 795359002459 Transglycosylase; Region: Transgly; cl07896 795359002460 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 795359002461 active site 795359002462 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 795359002463 active site 1 [active] 795359002464 active site 2 [active] 795359002465 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 795359002466 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 795359002467 Protein of unknown function (DUF523); Region: DUF523; cl00733 795359002468 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 795359002469 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 795359002470 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 795359002471 active site 795359002472 metal binding site [ion binding]; metal-binding site 795359002473 DNA binding site [nucleotide binding] 795359002474 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359002475 ABC transporter signature motif; other site 795359002476 Walker B; other site 795359002477 D-loop; other site 795359002478 H-loop/switch region; other site 795359002479 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 795359002480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 795359002481 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 795359002482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359002483 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 795359002484 Walker A motif; other site 795359002485 ATP binding site [chemical binding]; other site 795359002486 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359002487 Walker B motif; other site 795359002488 arginine finger; other site 795359002489 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 795359002490 Protein of unknown function DUF58; Region: DUF58; pfam01882 795359002491 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 795359002492 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 795359002493 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 795359002494 Peptidase family M48; Region: Peptidase_M48; cl12018 795359002495 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 795359002496 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 795359002497 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 795359002498 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 795359002499 TRAM domain; Region: TRAM; cl01282 795359002500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359002501 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 795359002502 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 795359002503 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 795359002504 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 795359002505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 795359002506 ATP synthase A chain; Region: ATP-synt_A; cl00413 795359002507 ATP synthase subunit C; Region: ATP-synt_C; cl00466 795359002508 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 795359002509 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 795359002510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359002511 Walker A motif; other site 795359002512 ATP binding site [chemical binding]; other site 795359002513 Walker B motif; other site 795359002514 arginine finger; other site 795359002515 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 795359002516 HupF/HypC family; Region: HupF_HypC; cl00394 795359002517 Hydrogenase formation hypA family; Region: HypD; cl12072 795359002518 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 795359002519 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 795359002520 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 795359002521 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 795359002522 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 795359002523 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 795359002524 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359002525 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 795359002526 dimerization interface [polypeptide binding]; other site 795359002527 putative DNA binding site [nucleotide binding]; other site 795359002528 putative Zn2+ binding site [ion binding]; other site 795359002529 Predicted permease; Region: DUF318; cl00487 795359002530 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 795359002531 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 795359002532 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 795359002533 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 795359002534 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 795359002535 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 795359002536 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 795359002537 sensor protein ZraS; Provisional; Region: PRK10364 795359002538 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 795359002539 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 795359002540 dimer interface [polypeptide binding]; other site 795359002541 phosphorylation site [posttranslational modification] 795359002542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 795359002543 ATP binding site [chemical binding]; other site 795359002544 Mg2+ binding site [ion binding]; other site 795359002545 G-X-G motif; other site 795359002546 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 795359002547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359002548 active site 795359002549 phosphorylation site [posttranslational modification] 795359002550 intermolecular recognition site; other site 795359002551 dimerization interface [polypeptide binding]; other site 795359002552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359002553 Walker A motif; other site 795359002554 ATP binding site [chemical binding]; other site 795359002555 Walker B motif; other site 795359002556 arginine finger; other site 795359002557 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 795359002558 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 795359002559 thiosulfate reductase PhsA; Provisional; Region: PRK15488 795359002560 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 795359002561 putative [Fe4-S4] binding site [ion binding]; other site 795359002562 putative molybdopterin cofactor binding site [chemical binding]; other site 795359002563 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound...; Region: MopB_CT_Thiosulfate-R-like; cd02778 795359002564 putative molybdopterin cofactor binding site; other site 795359002565 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 795359002566 Domain of unknown function DUF302; Region: DUF302; cl01364 795359002567 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 795359002568 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 795359002569 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 795359002570 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 795359002571 active site 795359002572 HIGH motif; other site 795359002573 nucleotide binding site [chemical binding]; other site 795359002574 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 795359002575 active site 795359002576 KMSKS motif; other site 795359002577 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 795359002578 tRNA binding surface [nucleotide binding]; other site 795359002579 anticodon binding site; other site 795359002580 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 795359002581 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 795359002582 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 795359002583 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 795359002584 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 795359002585 GIY-YIG motif/motif A; other site 795359002586 active site 795359002587 catalytic site [active] 795359002588 putative DNA binding site [nucleotide binding]; other site 795359002589 metal binding site [ion binding]; metal-binding site 795359002590 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 795359002591 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 795359002592 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 795359002593 DNA binding residues [nucleotide binding] 795359002594 dimerization interface [polypeptide binding]; other site 795359002595 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 795359002596 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 795359002597 Curli assembly protein CsgE; Region: CsgE; cl08115 795359002598 Curli production assembly/transport component CsgF; Region: Tafi-CsgF; cl08082 795359002599 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 795359002600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359002601 Ribulose 1,5-bisphosphate synthetase, converts PRPP to RuBP, flavoprotein [Carbohydrate transport and metabolism]; Region: THI4; COG1635 795359002602 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 795359002603 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 795359002604 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 795359002605 Walker A motif; other site 795359002606 ATP binding site [chemical binding]; other site 795359002607 Walker B motif; other site 795359002608 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 795359002609 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 795359002610 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 795359002611 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 795359002612 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359002613 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 795359002614 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 795359002615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359002616 TPR motif; other site 795359002617 binding surface 795359002618 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 795359002619 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 795359002620 Uncharacterized conserved protein [Function unknown]; Region: COG1912 795359002621 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 795359002622 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 795359002623 Ligand Binding Site [chemical binding]; other site 795359002624 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 795359002625 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 795359002626 Walker A/P-loop; other site 795359002627 ATP binding site [chemical binding]; other site 795359002628 Q-loop/lid; other site 795359002629 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 795359002630 Q-loop/lid; other site 795359002631 ABC transporter signature motif; other site 795359002632 Walker B; other site 795359002633 D-loop; other site 795359002634 H-loop/switch region; other site 795359002635 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 795359002636 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 795359002637 Walker A/P-loop; other site 795359002638 ATP binding site [chemical binding]; other site 795359002639 Q-loop/lid; other site 795359002640 ABC transporter signature motif; other site 795359002641 Walker B; other site 795359002642 D-loop; other site 795359002643 H-loop/switch region; other site 795359002644 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 795359002645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 795359002646 dimer interface [polypeptide binding]; other site 795359002647 conserved gate region; other site 795359002648 putative PBP binding loops; other site 795359002649 ABC-ATPase subunit interface; other site 795359002650 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 795359002651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 795359002652 cell division protein MraZ; Reviewed; Region: PRK00326 795359002653 MraZ protein; Region: MraZ; pfam02381 795359002654 MraZ protein; Region: MraZ; pfam02381 795359002655 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 795359002656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359002657 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 795359002658 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 795359002659 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 795359002660 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 795359002661 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 795359002662 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 795359002663 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 795359002664 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 795359002665 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 795359002666 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 795359002667 Mg++ binding site [ion binding]; other site 795359002668 putative catalytic motif [active] 795359002669 putative substrate binding site [chemical binding]; other site 795359002670 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 795359002671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359002672 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 795359002673 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 795359002674 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 795359002675 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 795359002676 active site 795359002677 homodimer interface [polypeptide binding]; other site 795359002678 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 795359002679 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 795359002680 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 795359002681 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 795359002682 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 795359002683 FAD binding domain; Region: FAD_binding_4; pfam01565 795359002684 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 795359002685 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 795359002686 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 795359002687 cell division protein FtsA; Region: ftsA; TIGR01174 795359002688 Cell division protein FtsA; Region: FtsA; cl11496 795359002689 Cell division protein FtsA; Region: FtsA; cl11496 795359002690 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 795359002691 cell division protein FtsZ; Validated; Region: PRK09330 795359002692 nucleotide binding site [chemical binding]; other site 795359002693 SulA interaction site; other site 795359002694 ParB-like nuclease domain; Region: ParBc; cl02129 795359002695 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 795359002696 putative ligand binding pocket/active site [active] 795359002697 putative metal binding site [ion binding]; other site 795359002698 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 795359002699 active site 795359002700 Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; cl01957 795359002701 bZIP transcription factor; Region: bZIP_1; cl02576 795359002702 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 795359002703 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 795359002704 dimerization interface [polypeptide binding]; other site 795359002705 domain crossover interface; other site 795359002706 redox-dependent activation switch; other site 795359002707 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 795359002708 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 795359002709 heterodimer interface [polypeptide binding]; other site 795359002710 active site 795359002711 FMN binding site [chemical binding]; other site 795359002712 homodimer interface [polypeptide binding]; other site 795359002713 substrate binding site [chemical binding]; other site 795359002714 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 795359002715 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 795359002716 FAD binding pocket [chemical binding]; other site 795359002717 FAD binding motif [chemical binding]; other site 795359002718 phosphate binding motif [ion binding]; other site 795359002719 beta-alpha-beta structure motif; other site 795359002720 NAD binding pocket [chemical binding]; other site 795359002721 Iron coordination center [ion binding]; other site 795359002722 Flagellin N-methylase; Region: FliB; cl00497 795359002723 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 795359002724 MatE; Region: MatE; cl10513 795359002725 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 795359002726 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 795359002727 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 795359002728 dimerization interface [polypeptide binding]; other site 795359002729 active site 795359002730 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 795359002731 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 795359002732 active site 795359002733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359002734 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 795359002735 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 795359002736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359002737 binding surface 795359002738 TPR motif; other site 795359002739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359002740 binding surface 795359002741 TPR motif; other site 795359002742 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 795359002743 Radical SAM; Region: Elp3; smart00729 795359002744 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359002745 FeS/SAM binding site; other site 795359002746 sensor protein ZraS; Provisional; Region: PRK10364 795359002747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 795359002748 dimer interface [polypeptide binding]; other site 795359002749 phosphorylation site [posttranslational modification] 795359002750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 795359002751 ATP binding site [chemical binding]; other site 795359002752 Mg2+ binding site [ion binding]; other site 795359002753 G-X-G motif; other site 795359002754 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 795359002755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359002756 active site 795359002757 phosphorylation site [posttranslational modification] 795359002758 intermolecular recognition site; other site 795359002759 dimerization interface [polypeptide binding]; other site 795359002760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359002761 Walker A motif; other site 795359002762 ATP binding site [chemical binding]; other site 795359002763 Walker B motif; other site 795359002764 arginine finger; other site 795359002765 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 795359002766 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 795359002767 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 795359002768 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359002769 FeS/SAM binding site; other site 795359002770 TRAM domain; Region: TRAM; cl01282 795359002771 Creatinine amidohydrolase; Region: Creatininase; cl00618 795359002772 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 795359002773 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine residue is found in...; Region: RNA_Cyclase_Class_II; cd00874 795359002774 putative active site [active] 795359002775 adenylation catalytic residue [active] 795359002776 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 795359002777 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 795359002778 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 795359002779 active site 795359002780 precorrin-2 dehydrogenase; Validated; Region: PRK06719 795359002781 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 795359002782 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 795359002783 nudix motif; other site 795359002784 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 795359002785 Found in ATP-dependent protease La (LON); Region: LON; smart00464 795359002786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359002787 Walker A motif; other site 795359002788 ATP binding site [chemical binding]; other site 795359002789 Walker B motif; other site 795359002790 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 795359002791 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 795359002792 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 795359002793 RNA/DNA hybrid binding site [nucleotide binding]; other site 795359002794 active site 795359002795 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 795359002796 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 795359002797 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 795359002798 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 795359002799 active site 795359002800 dimer interface [polypeptide binding]; other site 795359002801 effector binding site; other site 795359002802 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 795359002803 homoserine dehydrogenase; Provisional; Region: PRK06349 795359002804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359002805 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 795359002806 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 795359002807 CheD chemotactic sensory transduction; Region: CheD; cl00810 795359002808 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 795359002809 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 795359002810 Zn2+ binding site [ion binding]; other site 795359002811 Mg2+ binding site [ion binding]; other site 795359002812 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 795359002813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359002814 Walker A motif; other site 795359002815 ATP binding site [chemical binding]; other site 795359002816 Walker B motif; other site 795359002817 arginine finger; other site 795359002818 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 795359002819 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 795359002820 recombination protein RecR; Reviewed; Region: recR; PRK00076 795359002821 RecR protein; Region: RecR; pfam02132 795359002822 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 795359002823 putative active site [active] 795359002824 putative metal-binding site [ion binding]; other site 795359002825 tetramer interface [polypeptide binding]; other site 795359002826 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 795359002827 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 795359002828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 795359002829 putative substrate translocation pore; other site 795359002830 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 795359002831 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 795359002832 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 795359002833 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 795359002834 AIR carboxylase; Region: AIRC; cl00310 795359002835 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 795359002836 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 795359002837 CPxP motif; other site 795359002838 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 795359002839 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 795359002840 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 795359002841 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 795359002842 inhibitor-cofactor binding pocket; inhibition site 795359002843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 795359002844 catalytic residue [active] 795359002845 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 795359002846 Metal-binding active site; metal-binding site 795359002847 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 795359002848 N-acetyl-D-glucosamine binding site [chemical binding]; other site 795359002849 catalytic residue [active] 795359002850 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 795359002851 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 795359002852 intersubunit interface [polypeptide binding]; other site 795359002853 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 795359002854 Protein export membrane protein; Region: SecD_SecF; cl14618 795359002855 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 795359002856 Protein export membrane protein; Region: SecD_SecF; cl14618 795359002857 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 795359002858 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 795359002859 putative active site [active] 795359002860 substrate binding site [chemical binding]; other site 795359002861 putative cosubstrate binding site; other site 795359002862 catalytic site [active] 795359002863 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 795359002864 substrate binding site [chemical binding]; other site 795359002865 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 795359002866 Clp amino terminal domain; Region: Clp_N; pfam02861 795359002867 Clp amino terminal domain; Region: Clp_N; pfam02861 795359002868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359002869 Walker A motif; other site 795359002870 ATP binding site [chemical binding]; other site 795359002871 Walker B motif; other site 795359002872 arginine finger; other site 795359002873 Protein of unknown function (DUF964); Region: DUF964; cl01483 795359002874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359002875 Walker A motif; other site 795359002876 ATP binding site [chemical binding]; other site 795359002877 Walker B motif; other site 795359002878 arginine finger; other site 795359002879 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 795359002880 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 795359002881 putative dimer interface [polypeptide binding]; other site 795359002882 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 795359002883 ATP binding site [chemical binding]; other site 795359002884 dimerization interface [polypeptide binding]; other site 795359002885 thiamine monophosphate kinase; Provisional; Region: PRK05731 795359002886 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 795359002887 active site 795359002888 multimer interface [polypeptide binding]; other site 795359002889 EamA-like transporter family; Region: EamA; cl01037 795359002890 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 795359002891 active site 795359002892 putative substrate binding region [chemical binding]; other site 795359002893 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 795359002894 C-terminal peptidase (prc); Region: prc; TIGR00225 795359002895 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 795359002896 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 795359002897 Catalytic dyad [active] 795359002898 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 795359002899 rRNA interaction site [nucleotide binding]; other site 795359002900 S8 interaction site; other site 795359002901 putative laminin-1 binding site; other site 795359002902 elongation factor Ts; Reviewed; Region: tsf; PRK12332 795359002903 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 795359002904 Elongation factor TS; Region: EF_TS; pfam00889 795359002905 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 795359002906 putative nucleotide binding site [chemical binding]; other site 795359002907 uridine monophosphate binding site [chemical binding]; other site 795359002908 homohexameric interface [polypeptide binding]; other site 795359002909 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 795359002910 hinge region; other site 795359002911 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 795359002912 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 795359002913 catalytic residue [active] 795359002914 putative FPP diphosphate binding site; other site 795359002915 putative FPP binding hydrophobic cleft; other site 795359002916 dimer interface [polypeptide binding]; other site 795359002917 putative IPP diphosphate binding site; other site 795359002918 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 795359002919 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 795359002920 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 795359002921 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 795359002922 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 795359002923 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 795359002924 BON domain; Region: BON; cl02771 795359002925 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 795359002926 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 795359002927 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 795359002928 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 795359002929 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 795359002930 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 795359002931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 795359002932 motif II; other site 795359002933 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 795359002934 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 795359002935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359002936 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 795359002937 putative FMN binding site [chemical binding]; other site 795359002938 NADPH bind site [chemical binding]; other site 795359002939 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 795359002940 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 795359002941 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 795359002942 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 795359002943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 795359002944 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 795359002945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 795359002946 UvrD/REP helicase; Region: UvrD-helicase; cl14126 795359002947 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 795359002948 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 795359002949 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 795359002950 Cupin domain; Region: Cupin_2; cl09118 795359002951 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 795359002952 feedback inhibition sensing region; other site 795359002953 homohexameric interface [polypeptide binding]; other site 795359002954 nucleotide binding site [chemical binding]; other site 795359002955 N-acetyl-L-glutamate binding site [chemical binding]; other site 795359002956 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 795359002957 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 795359002958 HIGH motif; other site 795359002959 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 795359002960 active site 795359002961 KMSKS motif; other site 795359002962 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 795359002963 tRNA binding surface [nucleotide binding]; other site 795359002964 anticodon binding site; other site 795359002965 PilZ domain; Region: PilZ; cl01260 795359002966 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 795359002967 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 795359002968 Walker A/P-loop; other site 795359002969 ATP binding site [chemical binding]; other site 795359002970 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 795359002971 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 795359002972 ABC transporter signature motif; other site 795359002973 Walker B; other site 795359002974 D-loop; other site 795359002975 H-loop/switch region; other site 795359002976 Predicted transcriptional regulators [Transcription]; Region: COG1318 795359002977 probable regulatory domain; Region: near_KaiC_dom; TIGR03879 795359002978 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 795359002979 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359002980 Walker A motif; other site 795359002981 ATP binding site [chemical binding]; other site 795359002982 Walker B motif; other site 795359002983 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 795359002984 pyruvate kinase; Provisional; Region: PRK05826 795359002985 domain interfaces; other site 795359002986 active site 795359002987 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 795359002988 ParB-like nuclease domain; Region: ParBc; cl02129 795359002989 ParB-like partition proteins; Region: parB_part; TIGR00180 795359002990 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 795359002991 ATP binding site [chemical binding]; other site 795359002992 active site 795359002993 substrate binding site [chemical binding]; other site 795359002994 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 795359002995 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 795359002996 putative active site [active] 795359002997 catalytic site [active] 795359002998 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 795359002999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 795359003000 ATP binding site [chemical binding]; other site 795359003001 putative Mg++ binding site [ion binding]; other site 795359003002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 795359003003 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 795359003004 nucleotide binding region [chemical binding]; other site 795359003005 ATP-binding site [chemical binding]; other site 795359003006 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 795359003007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359003008 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 795359003009 Walker A motif; other site 795359003010 ATP binding site [chemical binding]; other site 795359003011 Walker B motif; other site 795359003012 arginine finger; other site 795359003013 Protein of unknown function DUF91; Region: DUF91; cl00709 795359003014 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 795359003015 Uncharacterized conserved protein [Function unknown]; Region: COG1578 795359003016 Protein of unknown function DUF89; Region: DUF89; pfam01937 795359003017 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 795359003018 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 795359003019 active site 795359003020 metal binding site [ion binding]; metal-binding site 795359003021 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 795359003022 domain I; other site 795359003023 DNA binding groove [nucleotide binding] 795359003024 phosphate binding site [ion binding]; other site 795359003025 domain II; other site 795359003026 domain III; other site 795359003027 nucleotide binding site [chemical binding]; other site 795359003028 catalytic site [active] 795359003029 domain IV; other site 795359003030 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 795359003031 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 795359003032 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 795359003033 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 795359003034 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 795359003035 Ligand Binding Site [chemical binding]; other site 795359003036 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 795359003037 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 795359003038 FtsX-like permease family; Region: FtsX; pfam02687 795359003039 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 795359003040 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 795359003041 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 795359003042 Walker A/P-loop; other site 795359003043 ATP binding site [chemical binding]; other site 795359003044 Q-loop/lid; other site 795359003045 ABC transporter signature motif; other site 795359003046 Walker B; other site 795359003047 D-loop; other site 795359003048 H-loop/switch region; other site 795359003049 macrolide transporter subunit MacA; Provisional; Region: PRK11578 795359003050 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 795359003051 Protein of unknown function (DUF737); Region: DUF737; pfam05300 795359003052 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 795359003053 Outer membrane efflux protein; Region: OEP; pfam02321 795359003054 Outer membrane efflux protein; Region: OEP; pfam02321 795359003055 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 795359003056 MarC family integral membrane protein; Region: MarC; cl00919 795359003057 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 795359003058 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 795359003059 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 795359003060 RNA binding site [nucleotide binding]; other site 795359003061 active site 795359003062 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 795359003063 DHH family; Region: DHH; pfam01368 795359003064 DHHA1 domain; Region: DHHA1; pfam02272 795359003065 Ribosome-binding factor A; Region: RBFA; cl00542 795359003066 Protein of unknown function (DUF503); Region: DUF503; cl00669 795359003067 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 795359003068 translation initiation factor IF-2; Region: IF-2; TIGR00487 795359003069 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 795359003070 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 795359003071 G1 box; other site 795359003072 putative GEF interaction site [polypeptide binding]; other site 795359003073 GTP/Mg2+ binding site [chemical binding]; other site 795359003074 Switch I region; other site 795359003075 G2 box; other site 795359003076 G3 box; other site 795359003077 Switch II region; other site 795359003078 G4 box; other site 795359003079 G5 box; other site 795359003080 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 795359003081 Translation-initiation factor 2; Region: IF-2; pfam11987 795359003082 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 795359003083 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 795359003084 Ligand binding site [chemical binding]; other site 795359003085 oligomer interface [polypeptide binding]; other site 795359003086 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 795359003087 putative ligand binding pocket/active site [active] 795359003088 putative metal binding site [ion binding]; other site 795359003089 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 795359003090 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 795359003091 HIGH motif; other site 795359003092 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 795359003093 active site 795359003094 KMSKS motif; other site 795359003095 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 795359003096 active site 795359003097 I-site; other site 795359003098 metal binding site [ion binding]; metal-binding site 795359003099 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 795359003100 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 795359003101 conserved cys residue [active] 795359003102 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 795359003103 active site 795359003104 NTP binding site [chemical binding]; other site 795359003105 metal binding triad [ion binding]; metal-binding site 795359003106 antibiotic binding site [chemical binding]; other site 795359003107 HEPN domain; Region: HEPN; cl00824 795359003108 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 795359003109 dimer interface [polypeptide binding]; other site 795359003110 Autotransporter beta-domain; Region: Autotransporter; cl02365 795359003111 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 795359003112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359003113 Walker A motif; other site 795359003114 ATP binding site [chemical binding]; other site 795359003115 Walker B motif; other site 795359003116 arginine finger; other site 795359003117 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 795359003118 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 795359003119 Protein of unknown function (DUF524); Region: DUF524; pfam04411 795359003120 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 795359003121 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 795359003122 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 795359003123 FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 795359003124 putative active site [active] 795359003125 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 795359003126 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 795359003127 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 795359003128 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 795359003129 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 795359003130 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 795359003131 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 795359003132 CRISPR-associated protein, MJ1666 family; Region: cas_MJ1666; TIGR01897 795359003133 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 795359003134 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 795359003135 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 795359003136 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 795359003137 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 795359003138 putative active site pocket [active] 795359003139 dimerization interface [polypeptide binding]; other site 795359003140 putative catalytic residue [active] 795359003141 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 795359003142 putative active site pocket [active] 795359003143 dimerization interface [polypeptide binding]; other site 795359003144 putative catalytic residue [active] 795359003145 Domain of unknown function DUF; Region: DUF202; cl09954 795359003146 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 795359003147 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 795359003148 RNA binding surface [nucleotide binding]; other site 795359003149 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 795359003150 active site 795359003151 uracil binding [chemical binding]; other site 795359003152 K+ potassium transporter; Region: K_trans; cl01227 795359003153 CHASE4 domain; Region: CHASE4; cl01308 795359003154 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 795359003155 metal binding site [ion binding]; metal-binding site 795359003156 active site 795359003157 I-site; other site 795359003158 Peptidase family M54; Region: Peptidase_M54; cl00835 795359003159 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 795359003160 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 795359003161 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 795359003162 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 795359003163 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 795359003164 heme-binding residues [chemical binding]; other site 795359003165 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 795359003166 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 795359003167 active site 795359003168 HIGH motif; other site 795359003169 dimer interface [polypeptide binding]; other site 795359003170 KMSKS motif; other site 795359003171 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 795359003172 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 795359003173 nucleotide binding pocket [chemical binding]; other site 795359003174 K-X-D-G motif; other site 795359003175 catalytic site [active] 795359003176 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 795359003177 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 795359003178 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 795359003179 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 795359003180 Dimer interface [polypeptide binding]; other site 795359003181 BRCT sequence motif; other site 795359003182 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 795359003183 ResB-like family; Region: ResB; pfam05140 795359003184 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 795359003185 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 795359003186 Walker A/P-loop; other site 795359003187 ATP binding site [chemical binding]; other site 795359003188 Q-loop/lid; other site 795359003189 ABC transporter signature motif; other site 795359003190 Walker B; other site 795359003191 D-loop; other site 795359003192 H-loop/switch region; other site 795359003193 Predicted membrane protein [Function unknown]; Region: COG1511 795359003194 GTP-binding protein LepA; Provisional; Region: PRK05433 795359003195 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 795359003196 G1 box; other site 795359003197 putative GEF interaction site [polypeptide binding]; other site 795359003198 GTP/Mg2+ binding site [chemical binding]; other site 795359003199 Switch I region; other site 795359003200 G2 box; other site 795359003201 G3 box; other site 795359003202 Switch II region; other site 795359003203 G4 box; other site 795359003204 G5 box; other site 795359003205 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 795359003206 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 795359003207 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 795359003208 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 795359003209 Catalytic site [active] 795359003210 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 795359003211 PhoU domain; Region: PhoU; pfam01895 795359003212 PhoU domain; Region: PhoU; pfam01895 795359003213 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 795359003214 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 795359003215 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 795359003216 Ligand Binding Site [chemical binding]; other site 795359003217 TIGR00269 family protein; Region: TIGR00269 795359003218 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13943 795359003219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 795359003220 S-adenosylmethionine binding site [chemical binding]; other site 795359003221 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 795359003222 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 795359003223 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 795359003224 RNA binding surface [nucleotide binding]; other site 795359003225 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 795359003226 active site 795359003227 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 795359003228 Cation efflux family; Region: Cation_efflux; cl00316 795359003229 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 795359003230 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 795359003231 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 795359003232 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 795359003233 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 795359003234 active site 795359003235 dimerization interface [polypeptide binding]; other site 795359003236 ribonuclease PH; Reviewed; Region: rph; PRK00173 795359003237 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 795359003238 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 795359003239 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 795359003240 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 795359003241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359003242 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 795359003243 nickel responsive regulator; Provisional; Region: PRK04460 795359003244 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 795359003245 ribonuclease R; Region: RNase_R; TIGR02063 795359003246 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 795359003247 RNB domain; Region: RNB; pfam00773 795359003248 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 795359003249 RNA binding site [nucleotide binding]; other site 795359003250 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 795359003251 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 795359003252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 795359003253 homodimer interface [polypeptide binding]; other site 795359003254 catalytic residue [active] 795359003255 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 795359003256 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 795359003257 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 795359003258 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 795359003259 Walker A/P-loop; other site 795359003260 ATP binding site [chemical binding]; other site 795359003261 Q-loop/lid; other site 795359003262 ABC transporter signature motif; other site 795359003263 Walker B; other site 795359003264 D-loop; other site 795359003265 H-loop/switch region; other site 795359003266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359003267 MjaI restriction endonuclease; Region: RE_MjaI; pfam09568 795359003268 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 795359003269 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 795359003270 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 795359003271 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 795359003272 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 795359003273 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 795359003274 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 795359003275 putative nucleic acid binding region [nucleotide binding]; other site 795359003276 G-X-X-G motif; other site 795359003277 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 795359003278 RNA binding site [nucleotide binding]; other site 795359003279 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 795359003280 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 795359003281 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 795359003282 homodimer interface [polypeptide binding]; other site 795359003283 oligonucleotide binding site [chemical binding]; other site 795359003284 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 795359003285 active site 795359003286 motif I; other site 795359003287 motif II; other site 795359003288 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 795359003289 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 795359003290 putative active site [active] 795359003291 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 795359003292 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 795359003293 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 795359003294 Walker A/P-loop; other site 795359003295 ATP binding site [chemical binding]; other site 795359003296 Q-loop/lid; other site 795359003297 ABC transporter signature motif; other site 795359003298 Walker B; other site 795359003299 D-loop; other site 795359003300 H-loop/switch region; other site 795359003301 Peptidase family M48; Region: Peptidase_M48; cl12018 795359003302 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 795359003303 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 795359003304 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 795359003305 Domain of unknown function (DUF370); Region: DUF370; cl00898 795359003306 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 795359003307 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 795359003308 catalytic site [active] 795359003309 G-X2-G-X-G-K; other site 795359003310 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 795359003311 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 795359003312 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 795359003313 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 795359003314 hypothetical protein; Provisional; Region: PRK06361 795359003315 RNase P subunit p30; Region: RNase_P_p30; cl03389 795359003316 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 795359003317 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 795359003318 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 795359003319 FeoA domain; Region: FeoA; cl00838 795359003320 FeoA domain; Region: FeoA; cl00838 795359003321 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 795359003322 metal binding site [ion binding]; metal-binding site 795359003323 active site 795359003324 I-site; other site 795359003325 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 795359003326 Zn2+ binding site [ion binding]; other site 795359003327 Mg2+ binding site [ion binding]; other site 795359003328 FeoA domain; Region: FeoA; cl00838 795359003329 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 795359003330 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 795359003331 G1 box; other site 795359003332 GTP/Mg2+ binding site [chemical binding]; other site 795359003333 Switch I region; other site 795359003334 G2 box; other site 795359003335 G3 box; other site 795359003336 Switch II region; other site 795359003337 G4 box; other site 795359003338 G5 box; other site 795359003339 Nucleoside recognition; Region: Gate; cl00486 795359003340 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 795359003341 Nucleoside recognition; Region: Gate; cl00486 795359003342 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 795359003343 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 795359003344 nucleotide binding site/active site [active] 795359003345 HIT family signature motif; other site 795359003346 catalytic residue [active] 795359003347 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 795359003348 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 795359003349 active site 795359003350 HIGH motif; other site 795359003351 KMSKS motif; other site 795359003352 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 795359003353 tRNA binding surface [nucleotide binding]; other site 795359003354 anticodon binding site; other site 795359003355 PSP1 C-terminal conserved region; Region: PSP1; cl00770 795359003356 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 795359003357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359003358 FeS/SAM binding site; other site 795359003359 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 795359003360 Trm112p-like protein; Region: Trm112p; cl01066 795359003361 elongation factor P; Validated; Region: PRK00529 795359003362 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 795359003363 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 795359003364 RNA binding site [nucleotide binding]; other site 795359003365 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 795359003366 RNA binding site [nucleotide binding]; other site 795359003367 Protein of unknown function DUF43; Region: DUF43; pfam01861 795359003368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 795359003369 PAS domain S-box; Region: sensory_box; TIGR00229 795359003370 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 795359003371 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 795359003372 metal binding site [ion binding]; metal-binding site 795359003373 active site 795359003374 I-site; other site 795359003375 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 795359003376 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 795359003377 ATP cone domain; Region: ATP-cone; pfam03477 795359003378 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 795359003379 active site 795359003380 dimer interface [polypeptide binding]; other site 795359003381 Protein of unknown function (DUF763); Region: DUF763; cl00620 795359003382 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 795359003383 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 795359003384 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 795359003385 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl01295 795359003386 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 795359003387 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 795359003388 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 795359003389 catalytic triad [active] 795359003390 Ferredoxin [Energy production and conversion]; Region: COG1146 795359003391 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 795359003392 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 795359003393 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 795359003394 active site 795359003395 (T/H)XGH motif; other site 795359003396 Pilus assembly protein, PilO; Region: PilO; cl01234 795359003397 Pilus assembly protein, PilP; Region: PilP; cl01235 795359003398 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 795359003399 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 795359003400 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 795359003401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359003402 Glucose inhibited division protein A; Region: GIDA; pfam01134 795359003403 Preprotein translocase subunit; Region: YajC; cl00806 795359003404 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 795359003405 aspartate aminotransferase; Provisional; Region: PRK06836 795359003406 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 795359003407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 795359003408 homodimer interface [polypeptide binding]; other site 795359003409 catalytic residue [active] 795359003410 acetylornithine deacetylase; Provisional; Region: PRK08652 795359003411 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 795359003412 metal binding site [ion binding]; metal-binding site 795359003413 dimer interface [polypeptide binding]; other site 795359003414 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 795359003415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 795359003416 Coenzyme A binding pocket [chemical binding]; other site 795359003417 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 795359003418 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 795359003419 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 795359003420 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 795359003421 DEAD-like helicases superfamily; Region: DEXDc; smart00487 795359003422 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359003423 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 795359003424 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 795359003425 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 795359003426 HEPN domain; Region: HEPN; cl00824 795359003427 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 795359003428 active site 795359003429 NTP binding site [chemical binding]; other site 795359003430 metal binding triad [ion binding]; metal-binding site 795359003431 antibiotic binding site [chemical binding]; other site 795359003432 Chromate transporter; Region: Chromate_transp; pfam02417 795359003433 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 795359003434 Chromate transporter; Region: Chromate_transp; pfam02417 795359003435 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 795359003436 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 795359003437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359003438 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 795359003439 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 795359003440 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 795359003441 inhibitor-cofactor binding pocket; inhibition site 795359003442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 795359003443 catalytic residue [active] 795359003444 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 795359003445 putative ATP binding site [chemical binding]; other site 795359003446 putative substrate binding site [chemical binding]; other site 795359003447 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 795359003448 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 795359003449 CPxP motif; other site 795359003450 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 795359003451 Ligand Binding Site [chemical binding]; other site 795359003452 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 795359003453 Ligand Binding Site [chemical binding]; other site 795359003454 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 795359003455 Phosphate transporter family; Region: PHO4; cl00396 795359003456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 795359003457 phosphorylation site [posttranslational modification] 795359003458 dimer interface [polypeptide binding]; other site 795359003459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 795359003460 ATP binding site [chemical binding]; other site 795359003461 Mg2+ binding site [ion binding]; other site 795359003462 G-X-G motif; other site 795359003463 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 795359003464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359003465 active site 795359003466 phosphorylation site [posttranslational modification] 795359003467 intermolecular recognition site; other site 795359003468 dimerization interface [polypeptide binding]; other site 795359003469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359003470 Walker A motif; other site 795359003471 ATP binding site [chemical binding]; other site 795359003472 Walker B motif; other site 795359003473 arginine finger; other site 795359003474 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 795359003475 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 795359003476 homodimer interaction site [polypeptide binding]; other site 795359003477 cofactor binding site; other site 795359003478 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 795359003479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 795359003480 catalytic residue [active] 795359003481 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 795359003482 archaeal radical SAM protein, PTO1314 family; Region: rSAM_PTO1314; TIGR03961 795359003483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359003484 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 795359003485 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 795359003486 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 795359003487 active site 795359003488 dimer interface [polypeptide binding]; other site 795359003489 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 795359003490 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 795359003491 active site 795359003492 FMN binding site [chemical binding]; other site 795359003493 substrate binding site [chemical binding]; other site 795359003494 3Fe-4S cluster binding site [ion binding]; other site 795359003495 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 795359003496 domain interface; other site 795359003497 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 795359003498 NAD synthase; Region: NAD_synthase; pfam02540 795359003499 homodimer interface [polypeptide binding]; other site 795359003500 NAD binding pocket [chemical binding]; other site 795359003501 ATP binding pocket [chemical binding]; other site 795359003502 Mg binding site [ion binding]; other site 795359003503 active-site loop [active] 795359003504 glutamine synthetase, type I; Region: GlnA; TIGR00653 795359003505 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 795359003506 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 795359003507 Nif-specific regulatory protein; Region: nifA; TIGR01817 795359003508 GAF domain; Region: GAF; cl00853 795359003509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359003510 Walker A motif; other site 795359003511 ATP binding site [chemical binding]; other site 795359003512 Walker B motif; other site 795359003513 arginine finger; other site 795359003514 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 795359003515 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 795359003516 catalytic triad [active] 795359003517 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 795359003518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 795359003519 Transposase; Region: DEDD_Tnp_IS110; pfam01548 795359003520 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 795359003521 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 795359003522 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 795359003523 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 795359003524 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 795359003525 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 795359003526 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 795359003527 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 795359003528 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 795359003529 Walker A motif; other site 795359003530 Nitrogenase subunit NifH (ATPase) [Inorganic ion transport and metabolism]; Region: NifH; COG1348 795359003531 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme; Region: NifX_NifB; cl00252 795359003532 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 795359003533 PhoH-like protein; Region: PhoH; cl12134 795359003534 Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811 795359003535 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 795359003536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359003537 adenylosuccinate synthetase; Provisional; Region: PRK01117 795359003538 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 795359003539 GDP-binding site [chemical binding]; other site 795359003540 ACT binding site; other site 795359003541 IMP binding site; other site 795359003542 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 795359003543 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 795359003544 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 795359003545 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 795359003546 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 795359003547 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 795359003548 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 795359003549 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 795359003550 lipoyl-biotinyl attachment site [posttranslational modification]; other site 795359003551 biotin--protein ligase; Provisional; Region: PRK08330 795359003552 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 795359003553 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 795359003554 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 795359003555 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 795359003556 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 795359003557 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 795359003558 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 795359003559 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 795359003560 IMP binding site; other site 795359003561 dimer interface [polypeptide binding]; other site 795359003562 interdomain contacts; other site 795359003563 partial ornithine binding site; other site 795359003564 periplasmic folding chaperone; Provisional; Region: PRK10788 795359003565 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 795359003566 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359003567 Walker A/P-loop; other site 795359003568 ATP binding site [chemical binding]; other site 795359003569 Q-loop/lid; other site 795359003570 ABC transporter signature motif; other site 795359003571 Walker B; other site 795359003572 D-loop; other site 795359003573 H-loop/switch region; other site 795359003574 Peptidase family M23; Region: Peptidase_M23; pfam01551 795359003575 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 795359003576 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 795359003577 dimerization interface [polypeptide binding]; other site 795359003578 putative ATP binding site [chemical binding]; other site 795359003579 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 795359003580 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 795359003581 dimer interface [polypeptide binding]; other site 795359003582 motif 1; other site 795359003583 active site 795359003584 motif 2; other site 795359003585 motif 3; other site 795359003586 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 795359003587 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 795359003588 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 795359003589 SelB subfamily. SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of...; Region: SelB; cd04171 795359003590 G1 box; other site 795359003591 putative GEF interaction site [polypeptide binding]; other site 795359003592 GTP/Mg2+ binding site [chemical binding]; other site 795359003593 Switch I region; other site 795359003594 G2 box; other site 795359003595 G3 box; other site 795359003596 Switch II region; other site 795359003597 G4 box; other site 795359003598 G5 box; other site 795359003599 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires...; Region: selB_II; cd03696 795359003600 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 795359003601 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 795359003602 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 795359003603 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 795359003604 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 795359003605 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 795359003606 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 795359003607 substrate binding site [chemical binding]; other site 795359003608 ligand binding site [chemical binding]; other site 795359003609 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 795359003610 substrate binding site [chemical binding]; other site 795359003611 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 795359003612 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 795359003613 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 795359003614 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 795359003615 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 795359003616 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 795359003617 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 795359003618 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 795359003619 active site 795359003620 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 795359003621 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 795359003622 dimer interface [polypeptide binding]; other site 795359003623 anticodon binding site; other site 795359003624 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 795359003625 homodimer interface [polypeptide binding]; other site 795359003626 motif 1; other site 795359003627 active site 795359003628 motif 2; other site 795359003629 GAD domain; Region: GAD; pfam02938 795359003630 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 795359003631 motif 3; other site 795359003632 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 795359003633 Protein of unknown function DUF82; Region: DUF82; pfam01927 795359003634 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 795359003635 Fe-S cluster binding site [ion binding]; other site 795359003636 active site 795359003637 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 795359003638 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 795359003639 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 795359003640 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 795359003641 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 795359003642 Ligand binding site [chemical binding]; other site 795359003643 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 795359003644 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 795359003645 active site 795359003646 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 795359003647 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 795359003648 dimer interface [polypeptide binding]; other site 795359003649 active site 795359003650 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 795359003651 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 795359003652 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 795359003653 active site 795359003654 intersubunit interface [polypeptide binding]; other site 795359003655 zinc binding site [ion binding]; other site 795359003656 Na+ binding site [ion binding]; other site 795359003657 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 795359003658 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 795359003659 dimerization interface [polypeptide binding]; other site 795359003660 ATP binding site [chemical binding]; other site 795359003661 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 795359003662 dimerization interface [polypeptide binding]; other site 795359003663 ATP binding site [chemical binding]; other site 795359003664 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 795359003665 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 795359003666 NAD binding site [chemical binding]; other site 795359003667 dimerization interface [polypeptide binding]; other site 795359003668 product binding site; other site 795359003669 substrate binding site [chemical binding]; other site 795359003670 zinc binding site [ion binding]; other site 795359003671 catalytic residues [active] 795359003672 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 795359003673 6-phosphofructokinase; Provisional; Region: PRK03202 795359003674 active site 795359003675 ADP/pyrophosphate binding site [chemical binding]; other site 795359003676 dimerization interface [polypeptide binding]; other site 795359003677 allosteric effector site; other site 795359003678 fructose-1,6-bisphosphate binding site; other site 795359003679 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 795359003680 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 795359003681 Ferritin-like domain; Region: Ferritin; pfam00210 795359003682 ferroxidase diiron center [ion binding]; other site 795359003683 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 795359003684 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 795359003685 Walker A/P-loop; other site 795359003686 ATP binding site [chemical binding]; other site 795359003687 Q-loop/lid; other site 795359003688 ABC transporter signature motif; other site 795359003689 Walker B; other site 795359003690 D-loop; other site 795359003691 H-loop/switch region; other site 795359003692 Cobalt transport protein; Region: CbiQ; cl00463 795359003693 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 795359003694 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 795359003695 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670 795359003696 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine...; Region: URO-D_CIMS_like; cl00464 795359003697 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 795359003698 chaperone protein DnaJ; Provisional; Region: PRK14285 795359003699 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 795359003700 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 795359003701 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 795359003702 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 795359003703 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 795359003704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 795359003705 S-adenosylmethionine binding site [chemical binding]; other site 795359003706 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 795359003707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359003708 active site 795359003709 phosphorylation site [posttranslational modification] 795359003710 intermolecular recognition site; other site 795359003711 dimerization interface [polypeptide binding]; other site 795359003712 CheB methylesterase; Region: CheB_methylest; pfam01339 795359003713 Response regulator receiver domain; Region: Response_reg; pfam00072 795359003714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359003715 active site 795359003716 phosphorylation site [posttranslational modification] 795359003717 intermolecular recognition site; other site 795359003718 dimerization interface [polypeptide binding]; other site 795359003719 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 795359003720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 795359003721 Response regulator receiver domain; Region: Response_reg; pfam00072 795359003722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359003723 active site 795359003724 phosphorylation site [posttranslational modification] 795359003725 intermolecular recognition site; other site 795359003726 dimerization interface [polypeptide binding]; other site 795359003727 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 795359003728 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 795359003729 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 795359003730 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 795359003731 DNA binding residues [nucleotide binding] 795359003732 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 795359003733 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 795359003734 P-loop; other site 795359003735 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 795359003736 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 795359003737 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 795359003738 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 795359003739 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 795359003740 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 795359003741 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 795359003742 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 795359003743 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 795359003744 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 795359003745 FliP family; Region: FliP; cl00593 795359003746 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 795359003747 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 795359003748 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 795359003749 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 795359003750 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 795359003751 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 795359003752 DNA binding site [nucleotide binding] 795359003753 active site 795359003754 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 795359003755 putative ADP-ribose binding site [chemical binding]; other site 795359003756 putative active site [active] 795359003757 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 795359003758 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 795359003759 active site 795359003760 Rhomboid family; Region: Rhomboid; cl11446 795359003761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 795359003762 SapC; Region: SapC; pfam07277 795359003763 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 795359003764 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 795359003765 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 795359003766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 795359003767 S-adenosylmethionine binding site [chemical binding]; other site 795359003768 flagellin; Provisional; Region: PRK12806 795359003769 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 795359003770 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 795359003771 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 795359003772 active site 795359003773 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 795359003774 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359003775 FeS/SAM binding site; other site 795359003776 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 795359003777 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 795359003778 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 795359003779 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 795359003780 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 795359003781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359003782 binding surface 795359003783 TPR motif; other site 795359003784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359003785 TPR motif; other site 795359003786 binding surface 795359003787 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 795359003788 Domain of unknown function DUF21; Region: DUF21; pfam01595 795359003789 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 795359003790 Transporter associated domain; Region: CorC_HlyC; cl08393 795359003791 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 795359003792 Domain of unknown function DUF21; Region: DUF21; pfam01595 795359003793 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 795359003794 Transporter associated domain; Region: CorC_HlyC; cl08393 795359003795 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 795359003796 UvrD/REP helicase; Region: UvrD-helicase; cl14126 795359003797 UvrD/REP helicase; Region: UvrD-helicase; cl14126 795359003798 PilZ domain; Region: PilZ; cl01260 795359003799 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 795359003800 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 795359003801 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 795359003802 ATP binding site [chemical binding]; other site 795359003803 putative Mg++ binding site [ion binding]; other site 795359003804 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 795359003805 nucleotide binding region [chemical binding]; other site 795359003806 ATP-binding site [chemical binding]; other site 795359003807 TRCF domain; Region: TRCF; cl04088 795359003808 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 795359003809 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 795359003810 Domain of unknown function (DUF205); Region: DUF205; cl00410 795359003811 Protein of unknown function (DUF342); Region: DUF342; pfam03961 795359003812 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 795359003813 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 795359003814 Ligand Binding Site [chemical binding]; other site 795359003815 B3/4 domain; Region: B3_4; cl11458 795359003816 FtsH Extracellular; Region: FtsH_ext; pfam06480 795359003817 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 795359003818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359003819 Walker A motif; other site 795359003820 ATP binding site [chemical binding]; other site 795359003821 Walker B motif; other site 795359003822 arginine finger; other site 795359003823 Peptidase family M41; Region: Peptidase_M41; pfam01434 795359003824 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 795359003825 dihydropteroate synthase; Region: DHPS; TIGR01496 795359003826 substrate binding pocket [chemical binding]; other site 795359003827 dimer interface [polypeptide binding]; other site 795359003828 inhibitor binding site; inhibition site 795359003829 Uncharacterized conserved protein [Function unknown]; Region: COG1624 795359003830 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 795359003831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 795359003832 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 795359003833 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 795359003834 active site 795359003835 substrate binding site [chemical binding]; other site 795359003836 metal binding site [ion binding]; metal-binding site 795359003837 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 795359003838 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 795359003839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 795359003840 S-adenosylmethionine binding site [chemical binding]; other site 795359003841 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 795359003842 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359003843 FeS/SAM binding site; other site 795359003844 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 795359003845 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 795359003846 Sugar fermentation stimulation protein; Region: SfsA; cl00647 795359003847 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 795359003848 GIY-YIG motif/motif A; other site 795359003849 putative active site [active] 795359003850 putative metal binding site [ion binding]; other site 795359003851 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 795359003852 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 795359003853 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 795359003854 G1 box; other site 795359003855 GTP/Mg2+ binding site [chemical binding]; other site 795359003856 Switch I region; other site 795359003857 G2 box; other site 795359003858 G3 box; other site 795359003859 Switch II region; other site 795359003860 G4 box; other site 795359003861 G5 box; other site 795359003862 Domain of unknown function DUF143; Region: DUF143; cl00519 795359003863 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 795359003864 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 795359003865 glutaminase active site [active] 795359003866 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 795359003867 dimer interface [polypeptide binding]; other site 795359003868 active site 795359003869 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 795359003870 dimer interface [polypeptide binding]; other site 795359003871 active site 795359003872 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 795359003873 active site 795359003874 cytidylate kinase; Provisional; Region: cmk; PRK00023 795359003875 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359003876 Active site [active] 795359003877 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 795359003878 CMP-binding site; other site 795359003879 The sites determining sugar specificity; other site 795359003880 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 795359003881 putative RNA binding site [nucleotide binding]; other site 795359003882 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 795359003883 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 795359003884 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 795359003885 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 795359003886 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 795359003887 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 795359003888 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 795359003889 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 795359003890 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 795359003891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 795359003892 Coenzyme A binding pocket [chemical binding]; other site 795359003893 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359003894 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 795359003895 30S subunit binding site; other site 795359003896 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 795359003897 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 795359003898 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 795359003899 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 795359003900 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 795359003901 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 795359003902 Walker A/P-loop; other site 795359003903 ATP binding site [chemical binding]; other site 795359003904 Q-loop/lid; other site 795359003905 ABC transporter signature motif; other site 795359003906 Walker B; other site 795359003907 D-loop; other site 795359003908 H-loop/switch region; other site 795359003909 OstA-like protein; Region: OstA; cl00844 795359003910 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 795359003911 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 795359003912 ring oligomerisation interface [polypeptide binding]; other site 795359003913 ATP/Mg binding site [chemical binding]; other site 795359003914 stacking interactions; other site 795359003915 hinge regions; other site 795359003916 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 795359003917 oligomerisation interface [polypeptide binding]; other site 795359003918 mobile loop; other site 795359003919 roof hairpin; other site 795359003920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 795359003921 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359003922 Active site [active] 795359003923 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 795359003924 Protein of unknown function (DUF465); Region: DUF465; cl01070 795359003925 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 795359003926 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 795359003927 PYR/PP interface [polypeptide binding]; other site 795359003928 dimer interface [polypeptide binding]; other site 795359003929 TPP binding site [chemical binding]; other site 795359003930 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 795359003931 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 795359003932 TPP-binding site [chemical binding]; other site 795359003933 dimer interface [polypeptide binding]; other site 795359003934 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 795359003935 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 795359003936 putative valine binding site [chemical binding]; other site 795359003937 dimer interface [polypeptide binding]; other site 795359003938 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 795359003939 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 795359003940 transketolase; Reviewed; Region: PRK05899 795359003941 TPP-binding site [chemical binding]; other site 795359003942 dimer interface [polypeptide binding]; other site 795359003943 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 795359003944 PYR/PP interface [polypeptide binding]; other site 795359003945 dimer interface [polypeptide binding]; other site 795359003946 TPP binding site [chemical binding]; other site 795359003947 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 795359003948 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 795359003949 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 795359003950 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 795359003951 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 795359003952 Substrate binding site [chemical binding]; other site 795359003953 metal binding site [ion binding]; metal-binding site 795359003954 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 795359003955 Phosphotransferase enzyme family; Region: APH; pfam01636 795359003956 Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679 795359003957 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 795359003958 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 795359003959 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 795359003960 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 795359003961 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 795359003962 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359003963 Walker A motif; other site 795359003964 ATP binding site [chemical binding]; other site 795359003965 Walker B motif; other site 795359003966 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 795359003967 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 795359003968 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 795359003969 Beta-Casp domain; Region: Beta-Casp; cl12567 795359003970 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 795359003971 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 795359003972 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 795359003973 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 795359003974 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 795359003975 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 795359003976 synthetase active site [active] 795359003977 NTP binding site [chemical binding]; other site 795359003978 metal binding site [ion binding]; metal-binding site 795359003979 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 795359003980 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 795359003981 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 795359003982 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 795359003983 TPP-binding site; other site 795359003984 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 795359003985 PYR/PP interface [polypeptide binding]; other site 795359003986 dimer interface [polypeptide binding]; other site 795359003987 TPP binding site [chemical binding]; other site 795359003988 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 795359003989 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 795359003990 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 795359003991 substrate binding pocket [chemical binding]; other site 795359003992 chain length determination region; other site 795359003993 substrate-Mg2+ binding site; other site 795359003994 catalytic residues [active] 795359003995 aspartate-rich region 1; other site 795359003996 active site lid residues [active] 795359003997 aspartate-rich region 2; other site 795359003998 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 795359003999 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 795359004000 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 795359004001 generic binding surface II; other site 795359004002 generic binding surface I; other site 795359004003 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 795359004004 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 795359004005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 795359004006 S-adenosylmethionine binding site [chemical binding]; other site 795359004007 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 795359004008 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 795359004009 switch II; other site 795359004010 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 795359004011 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 795359004012 P loop nucleotide binding; other site 795359004013 switch II; other site 795359004014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 795359004015 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 795359004016 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 795359004017 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 795359004018 UPF0278 family; Region: UPF0278; cl00637 795359004019 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 795359004020 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 795359004021 HIGH motif; other site 795359004022 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 795359004023 active site 795359004024 KMSKS motif; other site 795359004025 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 795359004026 tRNA binding surface [nucleotide binding]; other site 795359004027 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 795359004028 isocitrate dehydrogenase; Validated; Region: PRK07362 795359004029 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 795359004030 Fe-S cluster binding site [ion binding]; other site 795359004031 active site 795359004032 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 795359004033 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 795359004034 dimer interface [polypeptide binding]; other site 795359004035 active site residues [active] 795359004036 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 795359004037 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 795359004038 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 795359004039 active site 795359004040 hydrophilic channel; other site 795359004041 dimerization interface [polypeptide binding]; other site 795359004042 catalytic residues [active] 795359004043 active site lid [active] 795359004044 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 795359004045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 795359004046 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 795359004047 oligomer interface [polypeptide binding]; other site 795359004048 putative active site [active] 795359004049 metal binding site [ion binding]; metal-binding site 795359004050 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 795359004051 elongation factor G; Reviewed; Region: PRK12740 795359004052 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 795359004053 G3 box; other site 795359004054 Switch II region; other site 795359004055 GTP/Mg2+ binding site [chemical binding]; other site 795359004056 G4 box; other site 795359004057 G5 box; other site 795359004058 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 795359004059 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 795359004060 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 795359004061 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 795359004062 MPT binding site; other site 795359004063 trimer interface [polypeptide binding]; other site 795359004064 selenophosphate synthetase; Provisional; Region: PRK00943 795359004065 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 795359004066 dimerization interface [polypeptide binding]; other site 795359004067 putative ATP binding site [chemical binding]; other site 795359004068 N subunit; Region: benz_CoA_bzdN; cl11464 795359004069 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 795359004070 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 795359004071 Transcriptional regulator [Transcription]; Region: LysR; COG0583 795359004072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 795359004073 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 795359004074 putative dimerization interface [polypeptide binding]; other site 795359004075 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 795359004076 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 795359004077 [4Fe-4S] binding site [ion binding]; other site 795359004078 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 795359004079 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 795359004080 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 795359004081 molybdopterin cofactor binding site; other site 795359004082 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 795359004083 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 795359004084 catalytic residues [active] 795359004085 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 795359004086 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 795359004087 Predicted integral membrane protein [Function unknown]; Region: COG0392 795359004088 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 795359004089 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 795359004090 nucleotide binding site/active site [active] 795359004091 HIT family signature motif; other site 795359004092 catalytic residue [active] 795359004093 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 795359004094 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 795359004095 active site 795359004096 HIGH motif; other site 795359004097 dimer interface [polypeptide binding]; other site 795359004098 KMSKS motif; other site 795359004099 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 795359004100 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 795359004101 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 795359004102 active site 795359004103 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 795359004104 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 795359004105 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 795359004106 domain interfaces; other site 795359004107 active site 795359004108 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 795359004109 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 795359004110 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 795359004111 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 795359004112 NADP binding site [chemical binding]; other site 795359004113 homopentamer interface [polypeptide binding]; other site 795359004114 substrate binding site [chemical binding]; other site 795359004115 active site 795359004116 FOG: CBS domain [General function prediction only]; Region: COG0517 795359004117 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 795359004118 Transporter associated domain; Region: CorC_HlyC; cl08393 795359004119 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 795359004120 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 795359004121 putative active site [active] 795359004122 catalytic triad [active] 795359004123 putative dimer interface [polypeptide binding]; other site 795359004124 aromatic acid decarboxylase; Validated; Region: PRK05920 795359004125 Flavoprotein; Region: Flavoprotein; cl08021 795359004126 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 795359004127 intersubunit interface [polypeptide binding]; other site 795359004128 active site 795359004129 catalytic residue [active] 795359004130 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 795359004131 RNA/DNA hybrid binding site [nucleotide binding]; other site 795359004132 active site 795359004133 Uncharacterized conserved protein [Function unknown]; Region: COG1565 795359004134 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 795359004135 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 795359004136 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 795359004137 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 795359004138 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 795359004139 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 795359004140 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 795359004141 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 795359004142 putative binding surface; other site 795359004143 active site 795359004144 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 795359004145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 795359004146 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 795359004147 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 795359004148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359004149 active site 795359004150 phosphorylation site [posttranslational modification] 795359004151 intermolecular recognition site; other site 795359004152 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 795359004153 dimer interface [polypeptide binding]; other site 795359004154 catalytic triad [active] 795359004155 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 795359004156 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 795359004157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 795359004158 S-adenosylmethionine binding site [chemical binding]; other site 795359004159 Peptidase family M48; Region: Peptidase_M48; cl12018 795359004160 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 795359004161 Chorismate mutase type II; Region: CM_2; cl00693 795359004162 prephenate dehydratase; Provisional; Region: PRK11898 795359004163 Prephenate dehydratase; Region: PDT; pfam00800 795359004164 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 795359004165 putative L-Phe binding site [chemical binding]; other site 795359004166 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 795359004167 putative RNA binding cleft [nucleotide binding]; other site 795359004168 NusA N-terminal domain; Region: NusA_N; pfam08529 795359004169 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 795359004170 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 795359004171 RNA binding site [nucleotide binding]; other site 795359004172 homodimer interface [polypeptide binding]; other site 795359004173 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 795359004174 G-X-X-G motif; other site 795359004175 Uncharacterised BCR, YhbC family COG0779; Region: DUF150; pfam02576 795359004176 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 795359004177 Sm1 motif; other site 795359004178 predicted subunit interaction site [polypeptide binding]; other site 795359004179 RNA binding pocket [nucleotide binding]; other site 795359004180 Sm2 motif; other site 795359004181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 795359004182 metabolite-proton symporter; Region: 2A0106; TIGR00883 795359004183 putative substrate translocation pore; other site 795359004184 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 795359004185 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 795359004186 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 795359004187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 795359004188 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 795359004189 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 795359004190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359004191 DNA polymerase III subunit beta; Validated; Region: PRK05643 795359004192 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 795359004193 putative DNA binding surface [nucleotide binding]; other site 795359004194 dimer interface [polypeptide binding]; other site 795359004195 beta-clamp/clamp loader binding surface; other site 795359004196 beta-clamp/translesion DNA polymerase binding surface; other site 795359004197 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 795359004198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 795359004199 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 795359004200 anchoring element; other site 795359004201 dimer interface [polypeptide binding]; other site 795359004202 ATP binding site [chemical binding]; other site 795359004203 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 795359004204 active site 795359004205 putative metal-binding site [ion binding]; other site 795359004206 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 795359004207 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 795359004208 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl01295 795359004209 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 795359004210 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 795359004211 heme-binding residues [chemical binding]; other site 795359004212 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 795359004213 heme-binding residues [chemical binding]; other site 795359004214 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 795359004215 heme-binding residues [chemical binding]; other site 795359004216 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 795359004217 heme-binding residues [chemical binding]; other site 795359004218 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 795359004219 Cysteine-rich domain; Region: CCG; pfam02754 795359004220 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 795359004221 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 795359004222 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 795359004223 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359004224 Walker A/P-loop; other site 795359004225 ATP binding site [chemical binding]; other site 795359004226 Q-loop/lid; other site 795359004227 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359004228 ABC transporter signature motif; other site 795359004229 Walker B; other site 795359004230 D-loop; other site 795359004231 H-loop/switch region; other site 795359004232 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359004233 ABC transporter signature motif; other site 795359004234 Walker B; other site 795359004235 D-loop; other site 795359004236 H-loop/switch region; other site 795359004237 hypothetical protein; Provisional; Region: PRK08609 795359004238 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 795359004239 active site 795359004240 primer binding site [nucleotide binding]; other site 795359004241 NTP binding site [chemical binding]; other site 795359004242 metal binding triad [ion binding]; metal-binding site 795359004243 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 795359004244 Beta-lactamase; Region: Beta-lactamase; cl01009 795359004245 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 795359004246 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 795359004247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359004248 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 795359004249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359004250 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 795359004251 shikimate kinase; Reviewed; Region: aroK; PRK00131 795359004252 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 795359004253 ADP binding site [chemical binding]; other site 795359004254 magnesium binding site [ion binding]; other site 795359004255 putative shikimate binding site; other site 795359004256 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 795359004257 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 795359004258 hinge; other site 795359004259 active site 795359004260 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 795359004261 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 795359004262 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 795359004263 shikimate binding site; other site 795359004264 NAD(P) binding site [chemical binding]; other site 795359004265 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 795359004266 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 795359004267 active site 795359004268 catalytic residue [active] 795359004269 dimer interface [polypeptide binding]; other site 795359004270 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 795359004271 purine monophosphate binding site [chemical binding]; other site 795359004272 dimer interface [polypeptide binding]; other site 795359004273 putative catalytic residues [active] 795359004274 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 795359004275 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 795359004276 FeS/SAM binding site; other site 795359004277 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 795359004278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359004279 active site 795359004280 phosphorylation site [posttranslational modification] 795359004281 intermolecular recognition site; other site 795359004282 dimerization interface [polypeptide binding]; other site 795359004283 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 795359004284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 795359004285 Walker A motif; other site 795359004286 ATP binding site [chemical binding]; other site 795359004287 Walker B motif; other site 795359004288 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 795359004289 primosome assembly protein PriA; Validated; Region: PRK05580 795359004290 primosome assembly protein PriA; Validated; Region: PRK05580 795359004291 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 795359004292 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 795359004293 ATP binding site [chemical binding]; other site 795359004294 putative Mg++ binding site [ion binding]; other site 795359004295 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 795359004296 active site 795359004297 tetramer interface [polypeptide binding]; other site 795359004298 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 795359004299 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 795359004300 Walker A motif; other site 795359004301 ATP binding site [chemical binding]; other site 795359004302 Walker B motif; other site 795359004303 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 795359004304 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 795359004305 Walker A motif; other site 795359004306 ATP binding site [chemical binding]; other site 795359004307 Walker B motif; other site 795359004308 NIL domain; Region: NIL; cl09633 795359004309 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 795359004310 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 795359004311 YcaO-like family; Region: YcaO; cl09146 795359004312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359004313 binding surface 795359004314 TPR motif; other site 795359004315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 795359004316 binding surface 795359004317 TPR motif; other site 795359004318 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 795359004319 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 795359004320 Ligand Binding Site [chemical binding]; other site 795359004321 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 795359004322 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 795359004323 GatB domain; Region: GatB_Yqey; cl11497 795359004324 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 795359004325 Initiation factor 2 subunit family; Region: IF-2B; pfam01008 795359004326 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 795359004327 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 795359004328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359004329 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 795359004330 trimer interface [polypeptide binding]; other site 795359004331 active site 795359004332 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 795359004333 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 795359004334 diiron binding motif [ion binding]; other site 795359004335 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 795359004336 YcaO-like family; Region: YcaO; cl09146 795359004337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 795359004338 binding surface 795359004339 TPR motif; other site 795359004340 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 795359004341 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 795359004342 DsrC like protein; Region: DsrC; cl01101 795359004343 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 795359004344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 795359004345 Coenzyme A binding pocket [chemical binding]; other site 795359004346 Sporulation related domain; Region: SPOR; cl10051 795359004347 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 795359004348 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 795359004349 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 795359004350 active site 795359004351 HIGH motif; other site 795359004352 KMSK motif region; other site 795359004353 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 795359004354 tRNA binding surface [nucleotide binding]; other site 795359004355 anticodon binding site; other site 795359004356 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 795359004357 active site 795359004358 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 795359004359 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 795359004360 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 795359004361 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 795359004362 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 795359004363 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 795359004364 dimer interface [polypeptide binding]; other site 795359004365 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 795359004366 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 795359004367 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 795359004368 dimerization interface [polypeptide binding]; other site 795359004369 active site 795359004370 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 795359004371 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 795359004372 DHHA2 domain; Region: DHHA2; pfam02833 795359004373 PilZ domain; Region: PilZ; cl01260 795359004374 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 795359004375 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 795359004376 flagellar motor protein MotB; Validated; Region: motB; PRK09041 795359004377 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 795359004378 ligand binding site [chemical binding]; other site 795359004379 GTP-binding protein Der; Reviewed; Region: PRK00093 795359004380 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 795359004381 G1 box; other site 795359004382 GTP/Mg2+ binding site [chemical binding]; other site 795359004383 Switch I region; other site 795359004384 G2 box; other site 795359004385 Switch II region; other site 795359004386 G3 box; other site 795359004387 G4 box; other site 795359004388 G5 box; other site 795359004389 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 795359004390 G1 box; other site 795359004391 GTP/Mg2+ binding site [chemical binding]; other site 795359004392 Switch I region; other site 795359004393 G2 box; other site 795359004394 G3 box; other site 795359004395 Switch II region; other site 795359004396 G4 box; other site 795359004397 G5 box; other site 795359004398 Archease protein family (DUF101/UPF0211); Region: Archease; cl00606 795359004399 Competence protein; Region: Competence; cl00471 795359004400 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 795359004401 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 795359004402 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 795359004403 catalytic residue [active] 795359004404 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 795359004405 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 795359004406 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 795359004407 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 795359004408 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 795359004409 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 795359004410 alpha subunit interaction interface [polypeptide binding]; other site 795359004411 Walker A motif; other site 795359004412 ATP binding site [chemical binding]; other site 795359004413 Walker B motif; other site 795359004414 inhibitor binding site; inhibition site 795359004415 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 795359004416 ATP synthase; Region: ATP-synt; cl00365 795359004417 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 795359004418 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 795359004419 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 795359004420 beta subunit interaction interface [polypeptide binding]; other site 795359004421 Walker A motif; other site 795359004422 ATP binding site [chemical binding]; other site 795359004423 Walker B motif; other site 795359004424 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 795359004425 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 795359004426 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 795359004427 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 795359004428 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 795359004429 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 795359004430 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 795359004431 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 795359004432 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 795359004433 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 795359004434 DivIVA protein; Region: DivIVA; pfam05103 795359004435 rod shape-determining protein MreC; Region: MreC; pfam04085 795359004436 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 795359004437 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560 795359004438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 795359004439 catalytic residue [active] 795359004440 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 795359004441 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 795359004442 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 795359004443 tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264 795359004444 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 795359004445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 795359004446 homodimer interface [polypeptide binding]; other site 795359004447 catalytic residue [active] 795359004448 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 795359004449 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 795359004450 active site 795359004451 catalytic residues [active] 795359004452 metal binding site [ion binding]; metal-binding site 795359004453 Cache domain; Region: Cache_1; pfam02743 795359004454 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 795359004455 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 795359004456 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 795359004457 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 795359004458 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 795359004459 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 795359004460 Rod binding protein; Region: Rod-binding; cl01626 795359004461 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 795359004462 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 795359004463 Flagellar L-ring protein; Region: FlgH; cl00905 795359004464 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515 795359004465 SAF domain; Region: SAF; cl00555 795359004466 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 795359004467 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 795359004468 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 795359004469 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 795359004470 fagellar hook-basal body proteins; Region: FlgEFG_subfam; TIGR03506 795359004471 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 795359004472 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 795359004473 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 795359004474 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 795359004475 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 795359004476 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 795359004477 Surface antigen; Region: Bac_surface_Ag; cl03097 795359004478 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 795359004479 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 795359004480 Walker A/P-loop; other site 795359004481 ATP binding site [chemical binding]; other site 795359004482 Q-loop/lid; other site 795359004483 ABC transporter signature motif; other site 795359004484 Walker B; other site 795359004485 D-loop; other site 795359004486 H-loop/switch region; other site 795359004487 LolC/E family; Region: lolCE; TIGR02212 795359004488 FtsX-like permease family; Region: FtsX; pfam02687 795359004489 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 795359004490 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 795359004491 dimer interface [polypeptide binding]; other site 795359004492 putative anticodon binding site; other site 795359004493 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 795359004494 motif 1; other site 795359004495 active site 795359004496 motif 2; other site 795359004497 motif 3; other site 795359004498 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 795359004499 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 795359004500 DNA binding site [nucleotide binding] 795359004501 Int/Topo IB signature motif; other site 795359004502 active site 795359004503 sensory histidine kinase AtoS; Provisional; Region: PRK11360 795359004504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 795359004505 ATP binding site [chemical binding]; other site 795359004506 Mg2+ binding site [ion binding]; other site 795359004507 G-X-G motif; other site 795359004508 Response regulator receiver domain; Region: Response_reg; pfam00072 795359004509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 795359004510 active site 795359004511 phosphorylation site [posttranslational modification] 795359004512 intermolecular recognition site; other site 795359004513 dimerization interface [polypeptide binding]; other site 795359004514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 795359004515 H+ Antiporter protein; Region: 2A0121; TIGR00900 795359004516 putative substrate translocation pore; other site 795359004517 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 795359004518 DNA-binding site [nucleotide binding]; DNA binding site 795359004519 RNA-binding motif; other site 795359004520 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 795359004521 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 795359004522 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 795359004523 Tetramer interface [polypeptide binding]; other site 795359004524 Active site [active] 795359004525 FMN-binding site [chemical binding]; other site 795359004526 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 795359004527 substrate binding site [chemical binding]; other site 795359004528 dimer interface [polypeptide binding]; other site 795359004529 aconitate hydratase; Validated; Region: PRK07229 795359004530 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 795359004531 substrate binding site [chemical binding]; other site 795359004532 ligand binding site [chemical binding]; other site 795359004533 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 795359004534 substrate binding site [chemical binding]; other site 795359004535 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 795359004536 Protein of unknown function (DUF2703); Region: DUF2703; pfam10865 795359004537 CTP synthetase; Validated; Region: pyrG; PRK05380 795359004538 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 795359004539 Catalytic site [active] 795359004540 Active site [active] 795359004541 UTP binding site [chemical binding]; other site 795359004542 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 795359004543 active site 795359004544 putative oxyanion hole; other site 795359004545 catalytic triad [active] 795359004546 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 795359004547 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 795359004548 Quinolinate synthetase A protein; Region: NadA; cl00420 795359004549 phosphodiesterase; Provisional; Region: PRK12704 795359004550 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 795359004551 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 795359004552 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 795359004553 putative active site [active] 795359004554 metal binding site [ion binding]; metal-binding site 795359004555 homodimer binding site [polypeptide binding]; other site 795359004556 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 795359004557 active site 795359004558 catalytic residues [active] 795359004559 metal binding site [ion binding]; metal-binding site 795359004560 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 795359004561 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 795359004562 NAD(P) binding site [chemical binding]; other site 795359004563 homotetramer interface [polypeptide binding]; other site 795359004564 homodimer interface [polypeptide binding]; other site 795359004565 active site 795359004566 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 795359004567 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 795359004568 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 795359004569 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 795359004570 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 795359004571 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 795359004572 dimer interface [polypeptide binding]; other site 795359004573 PYR/PP interface [polypeptide binding]; other site 795359004574 TPP binding site [chemical binding]; other site 795359004575 substrate binding site [chemical binding]; other site 795359004576 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 795359004577 TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea and some hyperthermophilic bacteria. PFOR catalyzes the...; Region: TPP_PFOR_porB_like; cd03376 795359004578 TPP-binding site [chemical binding]; other site 795359004579 putative dimer interface [polypeptide binding]; other site 795359004580 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 795359004581 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 795359004582 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 795359004583 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 795359004584 Ligand Binding Site [chemical binding]; other site 795359004585 Flagellin N-methylase; Region: FliB; cl00497 795359004586 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 795359004587 metal binding site 2 [ion binding]; metal-binding site 795359004588 putative DNA binding helix; other site 795359004589 metal binding site 1 [ion binding]; metal-binding site 795359004590 dimer interface [polypeptide binding]; other site 795359004591 structural Zn2+ binding site [ion binding]; other site 795359004592 Uncharacterized conserved protein [Function unknown]; Region: COG0327 795359004593 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 795359004594 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 795359004595 Putative zinc ribbon domain; Region: DUF164; pfam02591 795359004596 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 795359004597 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 795359004598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359004599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359004600 L-aspartate oxidase; Provisional; Region: PRK09077 795359004601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359004602 domain; Region: Succ_DH_flav_C; pfam02910 795359004603 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 795359004604 Sulfatase; Region: Sulfatase; cl10460 795359004605 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 795359004606 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 795359004607 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 795359004608 alanine racemase; Reviewed; Region: alr; PRK00053 795359004609 active site 795359004610 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 795359004611 dimer interface [polypeptide binding]; other site 795359004612 substrate binding site [chemical binding]; other site 795359004613 catalytic residues [active] 795359004614 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 795359004615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359004616 Domain of unknown function (DUF329); Region: DUF329; cl01144 795359004617 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 795359004618 Ligand Binding Site [chemical binding]; other site 795359004619 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 795359004620 Ligand Binding Site [chemical binding]; other site 795359004621 argininosuccinate lyase; Provisional; Region: PRK00855 795359004622 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 795359004623 active sites [active] 795359004624 tetramer interface [polypeptide binding]; other site 795359004625 Transposase IS200 like; Region: Y1_Tnp; cl00848 795359004626 ApbE family; Region: ApbE; cl00643 795359004627 Fumarase C-terminus; Region: Fumerase_C; cl00795 795359004628 Predicted transcriptional regulator [Transcription]; Region: COG1959 795359004629 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 795359004630 seryl-tRNA synthetase; Provisional; Region: PRK05431 795359004631 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 795359004632 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 795359004633 dimer interface [polypeptide binding]; other site 795359004634 active site 795359004635 motif 1; other site 795359004636 motif 2; other site 795359004637 motif 3; other site 795359004638 Staphylococcal nuclease homologues; Region: SNc; smart00318 795359004639 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 795359004640 Catalytic site; other site 795359004641 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 795359004642 Flagellar protein FliS; Region: FliS; cl00654 795359004643 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 795359004644 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 795359004645 FlaG protein; Region: FlaG; cl00591 795359004646 ornithine carbamoyltransferase; Provisional; Region: PRK00779 795359004647 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 795359004648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 795359004649 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 795359004650 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 795359004651 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 795359004652 Walker A/P-loop; other site 795359004653 ATP binding site [chemical binding]; other site 795359004654 Q-loop/lid; other site 795359004655 ABC transporter signature motif; other site 795359004656 Walker B; other site 795359004657 D-loop; other site 795359004658 H-loop/switch region; other site 795359004659 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 795359004660 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 795359004661 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 795359004662 Walker A/P-loop; other site 795359004663 ATP binding site [chemical binding]; other site 795359004664 Q-loop/lid; other site 795359004665 ABC transporter signature motif; other site 795359004666 Walker B; other site 795359004667 D-loop; other site 795359004668 H-loop/switch region; other site 795359004669 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097