-- dump date 20111121_015340 -- class Genbank::misc_feature -- table misc_feature_note -- id note 471852000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 471852000002 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 471852000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852000004 Walker A motif; other site 471852000005 ATP binding site [chemical binding]; other site 471852000006 Walker B motif; other site 471852000007 arginine finger; other site 471852000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 471852000009 DnaA box-binding interface [nucleotide binding]; other site 471852000010 DNA polymerase III subunit beta; Validated; Region: PRK07761 471852000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 471852000012 putative DNA binding surface [nucleotide binding]; other site 471852000013 dimer interface [polypeptide binding]; other site 471852000014 beta-clamp/clamp loader binding surface; other site 471852000015 beta-clamp/translesion DNA polymerase binding surface; other site 471852000016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852000017 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 471852000018 recombination protein F; Reviewed; Region: recF; PRK00064 471852000019 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 471852000020 Walker A/P-loop; other site 471852000021 ATP binding site [chemical binding]; other site 471852000022 Q-loop/lid; other site 471852000023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852000024 ABC transporter signature motif; other site 471852000025 Walker B; other site 471852000026 D-loop; other site 471852000027 H-loop/switch region; other site 471852000028 Protein of unknown function (DUF721); Region: DUF721; cl02324 471852000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 471852000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 471852000032 anchoring element; other site 471852000033 dimer interface [polypeptide binding]; other site 471852000034 ATP binding site [chemical binding]; other site 471852000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 471852000036 active site 471852000037 putative metal-binding site [ion binding]; other site 471852000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471852000039 DNA gyrase subunit A; Validated; Region: PRK05560 471852000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 471852000041 CAP-like domain; other site 471852000042 Active site [active] 471852000043 primary dimer interface [polypeptide binding]; other site 471852000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471852000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471852000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471852000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471852000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471852000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471852000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 471852000051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471852000052 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471852000053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471852000054 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 471852000055 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471852000056 Tannase and feruloyl esterase; Region: Tannase; pfam07519 471852000057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852000058 FAD binding domain; Region: FAD_binding_3; pfam01494 471852000059 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471852000060 CoenzymeA binding site [chemical binding]; other site 471852000061 subunit interaction site [polypeptide binding]; other site 471852000062 PHB binding site; other site 471852000063 Sulfate transporter family; Region: Sulfate_transp; cl00967 471852000064 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471852000065 Domain of unknown function DUF21; Region: DUF21; pfam01595 471852000066 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471852000067 Transporter associated domain; Region: CorC_HlyC; cl08393 471852000068 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 471852000069 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471852000070 Predicted membrane protein [Function unknown]; Region: COG2311 471852000071 Protein of unknown function (DUF418); Region: DUF418; cl12135 471852000072 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471852000073 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471852000074 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471852000075 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471852000076 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471852000077 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 471852000078 active site 471852000079 catalytic tetrad [active] 471852000080 NlpC/P60 family; Region: NLPC_P60; cl11438 471852000081 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471852000082 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471852000083 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471852000084 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471852000085 Phage integrase family; Region: Phage_integrase; pfam00589 471852000086 DNA binding site [nucleotide binding] 471852000087 Int/Topo IB signature motif; other site 471852000088 active site 471852000089 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471852000090 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852000091 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471852000092 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852000093 DNA-binding site [nucleotide binding]; DNA binding site 471852000094 UTRA domain; Region: UTRA; cl01230 471852000095 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449 471852000096 homodimer interface [polypeptide binding]; other site 471852000097 substrate-cofactor binding pocket; other site 471852000098 Aminotransferase class IV; Region: Aminotran_4; pfam01063 471852000099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852000100 catalytic residue [active] 471852000101 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 471852000102 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 471852000103 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471852000104 Sulfatase; Region: Sulfatase; cl10460 471852000105 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 471852000106 putative trimer interface [polypeptide binding]; other site 471852000107 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 471852000108 trimer interface [polypeptide binding]; other site 471852000109 active site 471852000110 substrate binding site [chemical binding]; other site 471852000111 putative CoA binding site [chemical binding]; other site 471852000112 CoA binding site [chemical binding]; other site 471852000113 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 471852000114 active site 471852000115 Rhomboid family; Region: Rhomboid; cl11446 471852000116 Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506 471852000117 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_5; cd05830 471852000118 active site 471852000119 catalytic site [active] 471852000120 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 471852000121 Glutamine amidotransferase class-I; Region: GATase; pfam00117 471852000122 glutamine binding [chemical binding]; other site 471852000123 catalytic triad [active] 471852000124 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852000125 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852000126 active site 471852000127 ATP binding site [chemical binding]; other site 471852000128 substrate binding site [chemical binding]; other site 471852000129 activation loop (A-loop); other site 471852000130 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 471852000131 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 471852000132 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 471852000133 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852000134 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852000135 active site 471852000136 ATP binding site [chemical binding]; other site 471852000137 substrate binding site [chemical binding]; other site 471852000138 activation loop (A-loop); other site 471852000139 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 471852000140 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 471852000141 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471852000142 Protein phosphatase 2C; Region: PP2C; pfam00481 471852000143 Active site [active] 471852000144 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471852000145 phosphopeptide binding site; other site 471852000146 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 471852000147 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471852000148 phosphopeptide binding site; other site 471852000149 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 471852000150 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 471852000151 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 471852000152 putative hemin binding site; other site 471852000153 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471852000154 ABC-ATPase subunit interface; other site 471852000155 dimer interface [polypeptide binding]; other site 471852000156 putative PBP binding regions; other site 471852000157 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 471852000158 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471852000159 Walker A/P-loop; other site 471852000160 ATP binding site [chemical binding]; other site 471852000161 Q-loop/lid; other site 471852000162 ABC transporter signature motif; other site 471852000163 Walker B; other site 471852000164 D-loop; other site 471852000165 H-loop/switch region; other site 471852000166 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 471852000167 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 471852000168 heme binding pocket [chemical binding]; other site 471852000169 heme ligand [chemical binding]; other site 471852000170 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471852000171 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852000172 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 471852000173 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 471852000174 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 471852000175 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 471852000176 potassium/proton antiporter; Reviewed; Region: PRK05326 471852000177 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 471852000178 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 471852000179 putative active site [active] 471852000180 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 471852000181 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471852000182 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471852000183 metal-binding site [ion binding] 471852000184 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471852000185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471852000186 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471852000187 metal-binding site [ion binding] 471852000188 Subtilisin inhibitor-like; Region: SSI; cl11594 471852000189 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471852000190 active site residue [active] 471852000191 PAS domain S-box; Region: sensory_box; TIGR00229 471852000192 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471852000193 putative active site [active] 471852000194 heme pocket [chemical binding]; other site 471852000195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471852000196 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471852000197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 471852000198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852000199 ATP binding site [chemical binding]; other site 471852000200 Mg2+ binding site [ion binding]; other site 471852000201 G-X-G motif; other site 471852000202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852000203 ATP binding site [chemical binding]; other site 471852000204 Mg2+ binding site [ion binding]; other site 471852000205 G-X-G motif; other site 471852000206 Amidinotransferase; Region: Amidinotransf; cl12043 471852000207 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 471852000208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852000209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852000210 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 471852000211 NAD(P) binding site [chemical binding]; other site 471852000212 active site 471852000213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852000214 S-adenosylmethionine binding site [chemical binding]; other site 471852000215 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852000216 Leucine carboxyl methyltransferase; Region: LCM; cl01306 471852000217 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471852000218 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852000219 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 471852000220 active site 471852000221 catalytic triad [active] 471852000222 dimer interface [polypeptide binding]; other site 471852000223 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852000224 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852000225 hypothetical protein; Validated; Region: PRK07586 471852000226 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471852000227 PYR/PP interface [polypeptide binding]; other site 471852000228 dimer interface [polypeptide binding]; other site 471852000229 TPP binding site [chemical binding]; other site 471852000230 TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This...; Region: TPP_BFDC; cd02002 471852000231 TPP-binding site [chemical binding]; other site 471852000232 dimer interface [polypeptide binding]; other site 471852000233 FAD binding domain; Region: FAD_binding_4; pfam01565 471852000234 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 471852000235 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852000236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852000237 active site 471852000238 phosphorylation site [posttranslational modification] 471852000239 intermolecular recognition site; other site 471852000240 dimerization interface [polypeptide binding]; other site 471852000241 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852000242 DNA binding residues [nucleotide binding] 471852000243 dimerization interface [polypeptide binding]; other site 471852000244 Histidine kinase; Region: HisKA_3; pfam07730 471852000245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852000246 MMPL family; Region: MMPL; pfam03176 471852000247 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471852000248 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471852000249 anti sigma factor interaction site; other site 471852000250 regulatory phosphorylation site [posttranslational modification]; other site 471852000251 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471852000252 active site 471852000253 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 471852000254 prephenate dehydratase; Provisional; Region: PRK11898 471852000255 Prephenate dehydratase; Region: PDT; pfam00800 471852000256 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 471852000257 putative L-Phe binding site [chemical binding]; other site 471852000258 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl01000 471852000259 seryl-tRNA synthetase; Provisional; Region: PRK05431 471852000260 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 471852000261 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 471852000262 dimer interface [polypeptide binding]; other site 471852000263 active site 471852000264 motif 1; other site 471852000265 motif 2; other site 471852000266 motif 3; other site 471852000267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852000268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471852000269 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 471852000270 active site 471852000271 motif I; other site 471852000272 motif II; other site 471852000273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471852000274 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 471852000275 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 471852000276 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852000277 active site 471852000278 ATP binding site [chemical binding]; other site 471852000279 substrate binding site [chemical binding]; other site 471852000280 activation loop (A-loop); other site 471852000281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471852000282 putative active site [active] 471852000283 heme pocket [chemical binding]; other site 471852000284 LysE type translocator; Region: LysE; cl00565 471852000285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852000286 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471852000287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852000288 Cupin domain; Region: Cupin_2; cl09118 471852000289 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 471852000290 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471852000291 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 471852000292 Domain of unknown function (DUF3480); Region: DUF3480; pfam11979 471852000293 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 471852000294 active site 471852000295 putative catalytic site [active] 471852000296 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471852000297 Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]; Region: CDC6; COG1474 471852000298 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471852000299 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852000300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852000301 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471852000302 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 471852000303 DNA binding residues [nucleotide binding] 471852000304 putative dimer interface [polypeptide binding]; other site 471852000305 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471852000306 DNA binding residues [nucleotide binding] 471852000307 cyclase homology domain; Region: CHD; cd07302 471852000308 nucleotidyl binding site; other site 471852000309 metal binding site [ion binding]; metal-binding site 471852000310 dimer interface [polypeptide binding]; other site 471852000311 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852000312 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 471852000313 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 471852000314 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852000315 Histidine kinase; Region: HisKA_3; pfam07730 471852000316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852000317 ATP binding site [chemical binding]; other site 471852000318 Mg2+ binding site [ion binding]; other site 471852000319 G-X-G motif; other site 471852000320 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852000321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852000322 active site 471852000323 phosphorylation site [posttranslational modification] 471852000324 intermolecular recognition site; other site 471852000325 dimerization interface [polypeptide binding]; other site 471852000326 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852000327 dimerization interface [polypeptide binding]; other site 471852000328 DNA binding residues [nucleotide binding] 471852000329 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 471852000330 putative substrate binding region [chemical binding]; other site 471852000331 FOG: CBS domain [General function prediction only]; Region: COG0517 471852000332 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC...; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 471852000333 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471852000334 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852000335 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852000336 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852000337 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 471852000338 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 471852000339 hypothetical protein; Provisional; Region: PRK08244 471852000340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852000341 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471852000342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852000343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852000344 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 471852000345 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471852000346 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 471852000347 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471852000348 catalytic residue [active] 471852000349 DGQHR domain; Region: DGQHR; cl14002 471852000350 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 471852000351 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 471852000352 Active Sites [active] 471852000353 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 471852000354 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852000355 Walker A/P-loop; other site 471852000356 ATP binding site [chemical binding]; other site 471852000357 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852000358 ABC transporter signature motif; other site 471852000359 Walker B; other site 471852000360 D-loop; other site 471852000361 H-loop/switch region; other site 471852000362 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 471852000363 Protein of unknown function DUF262; Region: DUF262; cl14890 471852000364 Protein of unknown function DUF262; Region: DUF262; cl14890 471852000365 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 471852000366 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 471852000367 putative active site [active] 471852000368 catalytic site [active] 471852000369 putative metal binding site [ion binding]; other site 471852000370 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 471852000371 putative active site; other site 471852000372 putative metal binding residues [ion binding]; other site 471852000373 signature motif; other site 471852000374 putative triphosphate binding site [ion binding]; other site 471852000375 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852000376 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852000377 active site 471852000378 ATP binding site [chemical binding]; other site 471852000379 substrate binding site [chemical binding]; other site 471852000380 activation loop (A-loop); other site 471852000381 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 471852000382 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471852000383 Active site [active] 471852000384 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471852000385 metal ion-dependent adhesion site (MIDAS); other site 471852000386 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471852000387 phosphopeptide binding site; other site 471852000388 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 471852000389 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 471852000390 substrate binding pocket [chemical binding]; other site 471852000391 membrane-bound complex binding site; other site 471852000392 hinge residues; other site 471852000393 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471852000394 putative acyl-acceptor binding pocket; other site 471852000395 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 471852000396 nudix motif; other site 471852000397 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 471852000398 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 471852000399 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471852000400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852000401 homodimer interface [polypeptide binding]; other site 471852000402 catalytic residue [active] 471852000403 Protein kinase domain; Region: Pkinase; pfam00069 471852000404 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852000405 active site 471852000406 ATP binding site [chemical binding]; other site 471852000407 substrate binding site [chemical binding]; other site 471852000408 activation loop (A-loop); other site 471852000409 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 471852000410 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 471852000411 hinge; other site 471852000412 active site 471852000413 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 471852000414 ATP binding site [chemical binding]; other site 471852000415 active site 471852000416 substrate binding site [chemical binding]; other site 471852000417 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 471852000418 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 471852000419 MOSC domain; Region: MOSC; pfam03473 471852000420 adenylosuccinate lyase; Provisional; Region: PRK07492 471852000421 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 471852000422 tetramer interface [polypeptide binding]; other site 471852000423 active site 471852000424 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 471852000425 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 471852000426 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 471852000427 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471852000428 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 471852000429 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 471852000430 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 471852000431 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 471852000432 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 471852000433 active site 471852000434 catalytic site [active] 471852000435 metal binding site [ion binding]; metal-binding site 471852000436 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471852000437 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852000438 DNA-binding site [nucleotide binding]; DNA binding site 471852000439 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471852000440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852000441 homodimer interface [polypeptide binding]; other site 471852000442 catalytic residue [active] 471852000443 Uncharacterized conserved protein [Function unknown]; Region: COG2128 471852000444 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 471852000445 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471852000446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852000447 putative substrate translocation pore; other site 471852000448 adenylosuccinate synthetase; Provisional; Region: PRK01117 471852000449 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 471852000450 GDP-binding site [chemical binding]; other site 471852000451 ACT binding site; other site 471852000452 IMP binding site; other site 471852000453 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 471852000454 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852000455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852000456 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 471852000457 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471852000458 active site 471852000459 intersubunit interface [polypeptide binding]; other site 471852000460 zinc binding site [ion binding]; other site 471852000461 Na+ binding site [ion binding]; other site 471852000462 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471852000463 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471852000464 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 471852000465 binding surface 471852000466 TPR motif; other site 471852000467 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 471852000468 active site 471852000469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852000470 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 471852000471 NAD(P) binding site [chemical binding]; other site 471852000472 active site 471852000473 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 471852000474 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471852000475 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471852000476 dimer interface [polypeptide binding]; other site 471852000477 active site 471852000478 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471852000479 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471852000480 dimer interface [polypeptide binding]; other site 471852000481 active site 471852000482 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 471852000483 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471852000484 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 471852000485 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852000486 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471852000487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852000488 NAD(P) binding site [chemical binding]; other site 471852000489 active site 471852000490 Acyl transferase domain; Region: Acyl_transf_1; cl08282 471852000491 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471852000492 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 471852000493 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 471852000494 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471852000495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852000496 putative substrate translocation pore; other site 471852000497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852000498 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852000499 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 471852000500 putative metal binding site [ion binding]; other site 471852000501 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471852000502 putative active site [active] 471852000503 putative metal binding site [ion binding]; other site 471852000504 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471852000505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852000506 NAD(P) binding site [chemical binding]; other site 471852000507 active site 471852000508 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852000509 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471852000510 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471852000511 DNA binding residues [nucleotide binding] 471852000512 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 471852000513 putative active site [active] 471852000514 putative metal binding residues [ion binding]; other site 471852000515 signature motif; other site 471852000516 putative triphosphate binding site [ion binding]; other site 471852000517 dimer interface [polypeptide binding]; other site 471852000518 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 471852000519 Clp amino terminal domain; Region: Clp_N; pfam02861 471852000520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852000521 Walker A motif; other site 471852000522 ATP binding site [chemical binding]; other site 471852000523 Walker B motif; other site 471852000524 arginine finger; other site 471852000525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852000526 Walker A motif; other site 471852000527 ATP binding site [chemical binding]; other site 471852000528 Walker B motif; other site 471852000529 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471852000530 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 471852000531 DNA binding residues [nucleotide binding] 471852000532 chaperone protein DnaJ; Provisional; Region: PRK14282 471852000533 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 471852000534 HSP70 interaction site [polypeptide binding]; other site 471852000535 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 471852000536 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 471852000537 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 471852000538 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 471852000539 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 471852000540 dimer interface [polypeptide binding]; other site 471852000541 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 471852000542 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 471852000543 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471852000544 Cysteine-rich domain; Region: CCG; pfam02754 471852000545 Cysteine-rich domain; Region: CCG; pfam02754 471852000546 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471852000547 trimer interface [polypeptide binding]; other site 471852000548 active site 471852000549 Predicted kinase [General function prediction only]; Region: COG0645 471852000550 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852000551 Active site [active] 471852000552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852000553 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 471852000554 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 471852000555 putative di-iron ligands [ion binding]; other site 471852000556 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 471852000557 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 471852000558 FAD binding pocket [chemical binding]; other site 471852000559 FAD binding motif [chemical binding]; other site 471852000560 phosphate binding motif [ion binding]; other site 471852000561 beta-alpha-beta structure motif; other site 471852000562 NAD binding pocket [chemical binding]; other site 471852000563 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471852000564 catalytic loop [active] 471852000565 iron binding site [ion binding]; other site 471852000566 Domain of unknown function (DUF385); Region: DUF385; cl04387 471852000567 Carboxylesterase family; Region: COesterase; pfam00135 471852000568 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852000569 substrate binding pocket [chemical binding]; other site 471852000570 catalytic triad [active] 471852000571 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 471852000572 putative active site pocket [active] 471852000573 dimerization interface [polypeptide binding]; other site 471852000574 putative catalytic residue [active] 471852000575 polyphosphate kinase; Provisional; Region: PRK05443 471852000576 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 471852000577 putative domain interface [polypeptide binding]; other site 471852000578 putative active site [active] 471852000579 catalytic site [active] 471852000580 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 471852000581 putative domain interface [polypeptide binding]; other site 471852000582 putative active site [active] 471852000583 catalytic site [active] 471852000584 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 471852000585 active site 471852000586 Ap6A binding site [chemical binding]; other site 471852000587 nudix motif; other site 471852000588 metal binding site [ion binding]; metal-binding site 471852000589 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 471852000590 putative active site; other site 471852000591 putative metal binding residues [ion binding]; other site 471852000592 signature motif; other site 471852000593 putative triphosphate binding site [ion binding]; other site 471852000594 CHAD domain; Region: CHAD; cl10506 471852000595 RNA polymerase sigma-70 factor, TIGR02960 family; Region: SigX5 471852000596 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852000597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852000598 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471852000599 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 471852000600 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471852000601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471852000602 Coenzyme A binding pocket [chemical binding]; other site 471852000603 Transcription factor WhiB; Region: Whib; pfam02467 471852000604 Rhomboid family; Region: Rhomboid; cl11446 471852000605 classical (c) SDRs; Region: SDR_c; cd05233 471852000606 NAD(P) binding site [chemical binding]; other site 471852000607 active site 471852000608 SpoOM protein; Region: Spo0M; pfam07070 471852000609 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 471852000610 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 471852000611 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 471852000612 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 471852000613 FAD binding site [chemical binding]; other site 471852000614 substrate binding site [chemical binding]; other site 471852000615 catalytic residues [active] 471852000616 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 471852000617 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 471852000618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852000619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852000620 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 471852000621 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471852000622 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471852000623 YCII-related domain; Region: YCII; cl00999 471852000624 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852000625 active site 471852000626 ATP binding site [chemical binding]; other site 471852000627 substrate binding site [chemical binding]; other site 471852000628 hypothetical protein; Provisional; Region: PRK14851 471852000629 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 471852000630 FMN binding site [chemical binding]; other site 471852000631 dimer interface [polypeptide binding]; other site 471852000632 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 471852000633 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852000634 Leucine carboxyl methyltransferase; Region: LCM; cl01306 471852000635 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 471852000636 quinone interaction residues [chemical binding]; other site 471852000637 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 471852000638 active site 471852000639 catalytic residues [active] 471852000640 FMN binding site [chemical binding]; other site 471852000641 substrate binding site [chemical binding]; other site 471852000642 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 471852000643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852000644 S-adenosylmethionine binding site [chemical binding]; other site 471852000645 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 471852000646 active site 471852000647 metal binding site [ion binding]; metal-binding site 471852000648 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 471852000649 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471852000650 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471852000651 DNA binding site [nucleotide binding] 471852000652 domain linker motif; other site 471852000653 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471852000654 dimerization interface [polypeptide binding]; other site 471852000655 ligand binding site [chemical binding]; other site 471852000656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852000657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852000658 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 471852000659 DNA binding residues [nucleotide binding] 471852000660 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 471852000661 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471852000662 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 471852000663 NAD binding site [chemical binding]; other site 471852000664 Phe binding site; other site 471852000665 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 471852000666 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 471852000667 putative active site [active] 471852000668 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 471852000669 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 471852000670 dimerization interface [polypeptide binding]; other site 471852000671 putative ATP binding site [chemical binding]; other site 471852000672 amidophosphoribosyltransferase; Provisional; Region: PRK07847 471852000673 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 471852000674 active site 471852000675 tetramer interface [polypeptide binding]; other site 471852000676 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471852000677 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852000678 active site 471852000679 ATP binding site [chemical binding]; other site 471852000680 substrate binding site [chemical binding]; other site 471852000681 activation loop (A-loop); other site 471852000682 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 471852000683 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 471852000684 calcium binding site 2 [ion binding]; other site 471852000685 active site 471852000686 catalytic triad [active] 471852000687 calcium binding site 1 [ion binding]; other site 471852000688 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471852000689 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471852000690 motif II; other site 471852000691 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 471852000692 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 471852000693 dimerization interface [polypeptide binding]; other site 471852000694 ATP binding site [chemical binding]; other site 471852000695 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 471852000696 dimerization interface [polypeptide binding]; other site 471852000697 ATP binding site [chemical binding]; other site 471852000698 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471852000699 conserved cys residue [active] 471852000700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852000701 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 471852000702 short chain dehydrogenase; Provisional; Region: PRK06181 471852000703 classical (c) SDRs; Region: SDR_c; cd05233 471852000704 NAD(P) binding site [chemical binding]; other site 471852000705 active site 471852000706 Uncharacterized conserved protein [Function unknown]; Region: COG2128 471852000707 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 471852000708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852000709 Secretory lipase; Region: LIP; pfam03583 471852000710 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471852000711 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 471852000712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852000713 NAD(P) binding site [chemical binding]; other site 471852000714 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471852000715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852000716 Protein of unknown function (DUF541); Region: SIMPL; cl01077 471852000717 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471852000718 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471852000719 NAD(P) binding site [chemical binding]; other site 471852000720 catalytic residues [active] 471852000721 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 471852000722 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471852000723 TPP-binding site [chemical binding]; other site 471852000724 tetramer interface [polypeptide binding]; other site 471852000725 heterodimer interface [polypeptide binding]; other site 471852000726 phosphorylation loop region [posttranslational modification] 471852000727 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471852000728 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471852000729 alpha subunit interface [polypeptide binding]; other site 471852000730 TPP binding site [chemical binding]; other site 471852000731 heterodimer interface [polypeptide binding]; other site 471852000732 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471852000733 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 471852000734 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471852000735 E3 interaction surface; other site 471852000736 lipoyl attachment site [posttranslational modification]; other site 471852000737 e3 binding domain; Region: E3_binding; pfam02817 471852000738 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 471852000739 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852000740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852000741 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 471852000742 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852000743 substrate binding site [chemical binding]; other site 471852000744 oxyanion hole (OAH) forming residues; other site 471852000745 trimer interface [polypeptide binding]; other site 471852000746 TspO/MBR family; Region: TspO_MBR; cl01379 471852000747 Carbon starvation protein CstA; Region: CstA; cl00856 471852000748 Protein of unknown function (DUF466); Region: DUF466; cl01082 471852000749 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852000750 Leucine carboxyl methyltransferase; Region: LCM; cl01306 471852000751 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852000752 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 471852000753 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852000754 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852000755 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471852000756 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471852000757 Walker A/P-loop; other site 471852000758 ATP binding site [chemical binding]; other site 471852000759 Q-loop/lid; other site 471852000760 ABC transporter signature motif; other site 471852000761 Walker B; other site 471852000762 D-loop; other site 471852000763 H-loop/switch region; other site 471852000764 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471852000765 ABC-ATPase subunit interface; other site 471852000766 dimer interface [polypeptide binding]; other site 471852000767 putative PBP binding regions; other site 471852000768 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 471852000769 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471852000770 putative ligand binding site [chemical binding]; other site 471852000771 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852000772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852000773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852000774 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471852000775 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471852000776 Walker A/P-loop; other site 471852000777 ATP binding site [chemical binding]; other site 471852000778 Q-loop/lid; other site 471852000779 ABC transporter signature motif; other site 471852000780 Walker B; other site 471852000781 D-loop; other site 471852000782 H-loop/switch region; other site 471852000783 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 471852000784 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 471852000785 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 471852000786 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 471852000787 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 471852000788 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 471852000789 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471852000790 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852000791 Walker A/P-loop; other site 471852000792 ATP binding site [chemical binding]; other site 471852000793 Q-loop/lid; other site 471852000794 ABC transporter signature motif; other site 471852000795 Walker B; other site 471852000796 D-loop; other site 471852000797 H-loop/switch region; other site 471852000798 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 471852000799 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852000800 Walker A/P-loop; other site 471852000801 ATP binding site [chemical binding]; other site 471852000802 Q-loop/lid; other site 471852000803 ABC transporter signature motif; other site 471852000804 Walker B; other site 471852000805 D-loop; other site 471852000806 H-loop/switch region; other site 471852000807 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471852000808 ABC-ATPase subunit interface; other site 471852000809 dimer interface [polypeptide binding]; other site 471852000810 putative PBP binding regions; other site 471852000811 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471852000812 ABC-ATPase subunit interface; other site 471852000813 dimer interface [polypeptide binding]; other site 471852000814 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 471852000815 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471852000816 Walker A/P-loop; other site 471852000817 ATP binding site [chemical binding]; other site 471852000818 Q-loop/lid; other site 471852000819 ABC transporter signature motif; other site 471852000820 Walker B; other site 471852000821 D-loop; other site 471852000822 H-loop/switch region; other site 471852000823 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852000824 Condensation domain; Region: Condensation; cl09290 471852000825 Nonribosomal peptide synthase; Region: NRPS; pfam08415 471852000826 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 471852000827 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471852000828 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852000829 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852000830 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471852000831 putative catalytic site [active] 471852000832 putative metal binding site [ion binding]; other site 471852000833 putative phosphate binding site [ion binding]; other site 471852000834 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 471852000835 enterobactin exporter EntS; Provisional; Region: PRK10489 471852000836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852000837 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 471852000838 tetramerization interface [polypeptide binding]; other site 471852000839 active site 471852000840 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 471852000841 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852000842 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471852000843 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471852000844 active site 471852000845 metal binding site [ion binding]; metal-binding site 471852000846 salicylate synthase MbtI; Reviewed; Region: PRK07912 471852000847 chorismate binding enzyme; Region: Chorismate_bind; cl10555 471852000848 Condensation domain; Region: Condensation; cl09290 471852000849 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471852000850 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852000851 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852000852 Condensation domain; Region: Condensation; cl09290 471852000853 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 471852000854 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852000855 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852000856 Condensation domain; Region: Condensation; cl09290 471852000857 peptide synthase; Provisional; Region: PRK12316 471852000858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852000859 S-adenosylmethionine binding site [chemical binding]; other site 471852000860 peptide synthase; Validated; Region: PRK05691 471852000861 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852000862 Condensation domain; Region: Condensation; cl09290 471852000863 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 471852000864 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852000865 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852000866 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471852000867 non-specific DNA binding site [nucleotide binding]; other site 471852000868 salt bridge; other site 471852000869 sequence-specific DNA binding site [nucleotide binding]; other site 471852000870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852000871 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471852000872 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852000873 active site 471852000874 ATP binding site [chemical binding]; other site 471852000875 substrate binding site [chemical binding]; other site 471852000876 activation loop (A-loop); other site 471852000877 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 471852000878 active site 471852000879 zinc binding site [ion binding]; other site 471852000880 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852000881 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471852000882 Walker A/P-loop; other site 471852000883 ATP binding site [chemical binding]; other site 471852000884 Q-loop/lid; other site 471852000885 ABC transporter signature motif; other site 471852000886 Walker B; other site 471852000887 D-loop; other site 471852000888 H-loop/switch region; other site 471852000889 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471852000890 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852000891 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852000892 active site 471852000893 ATP binding site [chemical binding]; other site 471852000894 substrate binding site [chemical binding]; other site 471852000895 activation loop (A-loop); other site 471852000896 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 471852000897 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 471852000898 putative active site [active] 471852000899 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 471852000900 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471852000901 Ligand Binding Site [chemical binding]; other site 471852000902 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 471852000903 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 471852000904 siderophore binding site; other site 471852000905 MbtH-like protein; Region: MbtH; cl01279 471852000906 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471852000907 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471852000908 FAD binding pocket [chemical binding]; other site 471852000909 FAD binding motif [chemical binding]; other site 471852000910 phosphate binding motif [ion binding]; other site 471852000911 NAD binding pocket [chemical binding]; other site 471852000912 Secretory lipase; Region: LIP; pfam03583 471852000913 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471852000914 isoform II; Region: PAF-AH_p_II; pfam03403 471852000915 PaaX-like protein; Region: PaaX; pfam07848 471852000916 OsmC-like protein; Region: OsmC; cl00767 471852000917 glutamate dehydrogenase; Provisional; Region: PRK09414 471852000918 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471852000919 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 471852000920 NAD(P) binding site [chemical binding]; other site 471852000921 Protein kinase domain; Region: Pkinase; pfam00069 471852000922 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852000923 active site 471852000924 ATP binding site [chemical binding]; other site 471852000925 substrate binding site [chemical binding]; other site 471852000926 activation loop (A-loop); other site 471852000927 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 471852000928 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471852000929 metal ion-dependent adhesion site (MIDAS); other site 471852000930 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471852000931 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 471852000932 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471852000933 putative active site [active] 471852000934 catalytic site [active] 471852000935 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471852000936 putative active site [active] 471852000937 catalytic site [active] 471852000938 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 471852000939 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 471852000940 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471852000941 catalytic residue [active] 471852000942 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471852000943 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 471852000944 catalytic loop [active] 471852000945 iron binding site [ion binding]; other site 471852000946 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 471852000947 FAD binding pocket [chemical binding]; other site 471852000948 conserved FAD binding motif [chemical binding]; other site 471852000949 phosphate binding motif [ion binding]; other site 471852000950 beta-alpha-beta structure motif; other site 471852000951 NAD binding pocket [chemical binding]; other site 471852000952 hybrid cluster protein; Provisional; Region: PRK05290 471852000953 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 471852000954 ACS interaction site; other site 471852000955 CODH interaction site; other site 471852000956 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 471852000957 hybrid metal cluster; other site 471852000958 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471852000959 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471852000960 ligand binding site [chemical binding]; other site 471852000961 flexible hinge region; other site 471852000962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852000963 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 471852000964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471852000965 dimerization interface [polypeptide binding]; other site 471852000966 putative DNA binding site [nucleotide binding]; other site 471852000967 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 471852000968 putative Zn2+ binding site [ion binding]; other site 471852000969 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 471852000970 tetramer interface [polypeptide binding]; other site 471852000971 active site 471852000972 Mg2+/Mn2+ binding site [ion binding]; other site 471852000973 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation...; Region: ASCH; cl01020 471852000974 Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611 471852000975 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 471852000976 ATP binding site [chemical binding]; other site 471852000977 dimerization interface [polypeptide binding]; other site 471852000978 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852000979 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852000980 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852000981 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852000982 active site 471852000983 ATP binding site [chemical binding]; other site 471852000984 substrate binding site [chemical binding]; other site 471852000985 activation loop (A-loop); other site 471852000986 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 471852000987 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 471852000988 structural tetrad; other site 471852000989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852000990 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852000991 Chlorophyllase; Region: Chlorophyllase; cl15281 471852000992 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471852000993 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 471852000994 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 471852000995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852000996 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 471852000997 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 471852000998 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 471852000999 Ligand binding site [chemical binding]; other site 471852001000 Ligand binding site [chemical binding]; other site 471852001001 Ligand binding site [chemical binding]; other site 471852001002 Putative Catalytic site [active] 471852001003 DXD motif; other site 471852001004 GtrA-like protein; Region: GtrA; cl00971 471852001005 CoA-transferase family III; Region: CoA_transf_3; cl00778 471852001006 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852001007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852001008 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 471852001009 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 471852001010 active site 471852001011 metal binding site [ion binding]; metal-binding site 471852001012 DNA binding site [nucleotide binding] 471852001013 Uncharacterized conserved protein [Function unknown]; Region: COG4717 471852001014 Uncharacterized conserved protein [Function unknown]; Region: COG4717 471852001015 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 471852001016 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471852001017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852001018 dimer interface [polypeptide binding]; other site 471852001019 conserved gate region; other site 471852001020 putative PBP binding loops; other site 471852001021 ABC-ATPase subunit interface; other site 471852001022 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471852001023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 471852001024 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 471852001025 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852001026 Walker A/P-loop; other site 471852001027 ATP binding site [chemical binding]; other site 471852001028 Q-loop/lid; other site 471852001029 ABC transporter signature motif; other site 471852001030 Walker B; other site 471852001031 D-loop; other site 471852001032 H-loop/switch region; other site 471852001033 TOBE domain; Region: TOBE_2; cl01440 471852001034 hypothetical protein; Provisional; Region: PRK07524 471852001035 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471852001036 PYR/PP interface [polypeptide binding]; other site 471852001037 dimer interface [polypeptide binding]; other site 471852001038 TPP binding site [chemical binding]; other site 471852001039 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471852001040 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 471852001041 TPP-binding site [chemical binding]; other site 471852001042 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 471852001043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852001044 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 471852001045 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852001046 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852001047 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852001048 active site 471852001049 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 471852001050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852001051 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 471852001052 short chain dehydrogenase; Provisional; Region: PRK07677 471852001053 NAD(P) binding site [chemical binding]; other site 471852001054 substrate binding site [chemical binding]; other site 471852001055 homotetramer interface [polypeptide binding]; other site 471852001056 active site 471852001057 homodimer interface [polypeptide binding]; other site 471852001058 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471852001059 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471852001060 NAD(P) binding site [chemical binding]; other site 471852001061 catalytic residues [active] 471852001062 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 471852001063 EamA-like transporter family; Region: EamA; cl01037 471852001064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 471852001065 binding surface 471852001066 TPR motif; other site 471852001067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 471852001068 binding surface 471852001069 TPR motif; other site 471852001070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 471852001071 binding surface 471852001072 TPR motif; other site 471852001073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 471852001074 binding surface 471852001075 TPR motif; other site 471852001076 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852001077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 471852001078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852001079 ATP binding site [chemical binding]; other site 471852001080 Mg2+ binding site [ion binding]; other site 471852001081 G-X-G motif; other site 471852001082 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051 471852001083 Ca2+ binding site [ion binding]; other site 471852001084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 471852001085 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471852001086 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 471852001087 Walker A/P-loop; other site 471852001088 ATP binding site [chemical binding]; other site 471852001089 Q-loop/lid; other site 471852001090 ABC transporter signature motif; other site 471852001091 Walker B; other site 471852001092 D-loop; other site 471852001093 H-loop/switch region; other site 471852001094 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 471852001095 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 471852001096 substrate binding pocket [chemical binding]; other site 471852001097 membrane-bound complex binding site; other site 471852001098 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 471852001099 active site 471852001100 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 471852001101 dimer interface [polypeptide binding]; other site 471852001102 non-prolyl cis peptide bond; other site 471852001103 insertion regions; other site 471852001104 Dienelactone hydrolase family; Region: DLH; pfam01738 471852001105 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 471852001106 Flavin Reductases; Region: FlaRed; cl00801 471852001107 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471852001108 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471852001109 active site residue [active] 471852001110 Cysteine dioxygenase type I; Region: CDO_I; cl02350 471852001111 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852001112 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471852001113 D-loop; other site 471852001114 H-loop/switch region; other site 471852001115 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852001116 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852001117 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852001118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852001119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852001120 rod shape-determining protein MreB; Provisional; Region: PRK13930 471852001121 Protein of unknown function, DUF488; Region: DUF488; cl01246 471852001122 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 471852001123 HSP90 family protein; Provisional; Region: PRK14083 471852001124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852001125 ATP binding site [chemical binding]; other site 471852001126 Mg2+ binding site [ion binding]; other site 471852001127 G-X-G motif; other site 471852001128 Protein of unknown function (DUF1012); Region: DUF1012; pfam06241 471852001129 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471852001130 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 471852001131 active site 471852001132 metal binding site [ion binding]; metal-binding site 471852001133 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471852001134 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471852001135 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471852001136 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852001137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852001138 active site 471852001139 phosphorylation site [posttranslational modification] 471852001140 intermolecular recognition site; other site 471852001141 dimerization interface [polypeptide binding]; other site 471852001142 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852001143 DNA binding residues [nucleotide binding] 471852001144 dimerization interface [polypeptide binding]; other site 471852001145 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471852001146 GAF domain; Region: GAF; cl00853 471852001147 GAF domain; Region: GAF; cl00853 471852001148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471852001149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852001150 ATP binding site [chemical binding]; other site 471852001151 Mg2+ binding site [ion binding]; other site 471852001152 G-X-G motif; other site 471852001153 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 471852001154 Condensation domain; Region: Condensation; cl09290 471852001155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852001156 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 471852001157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852001158 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 471852001159 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 471852001160 putative active site [active] 471852001161 putative metal binding site [ion binding]; other site 471852001162 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 471852001163 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471852001164 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852001165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852001166 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471852001167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852001168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852001169 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471852001170 mce related protein; Region: MCE; pfam02470 471852001171 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471852001172 mce related protein; Region: MCE; pfam02470 471852001173 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471852001174 mce related protein; Region: MCE; pfam02470 471852001175 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 471852001176 mce related protein; Region: MCE; pfam02470 471852001177 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471852001178 mce related protein; Region: MCE; pfam02470 471852001179 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471852001180 mce related protein; Region: MCE; pfam02470 471852001181 Domain of unknown function DUF140; Region: DUF140; cl00510 471852001182 Domain of unknown function DUF140; Region: DUF140; cl00510 471852001183 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 471852001184 DNA-binding site [nucleotide binding]; DNA binding site 471852001185 RNA-binding motif; other site 471852001186 helicase 45; Provisional; Region: PTZ00424 471852001187 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 471852001188 ATP binding site [chemical binding]; other site 471852001189 Mg++ binding site [ion binding]; other site 471852001190 motif III; other site 471852001191 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852001192 nucleotide binding region [chemical binding]; other site 471852001193 ATP-binding site [chemical binding]; other site 471852001194 DbpA RNA binding domain; Region: DbpA; pfam03880 471852001195 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 471852001196 dinuclear metal binding motif [ion binding]; other site 471852001197 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 471852001198 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 471852001199 dinuclear metal binding motif [ion binding]; other site 471852001200 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 471852001201 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471852001202 catalytic loop [active] 471852001203 iron binding site [ion binding]; other site 471852001204 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 471852001205 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471852001206 active site 471852001207 metal binding site [ion binding]; metal-binding site 471852001208 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 471852001209 tetramer interface [polypeptide binding]; other site 471852001210 active site 471852001211 Fe binding site [ion binding]; other site 471852001212 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 471852001213 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471852001214 catalytic loop [active] 471852001215 iron binding site [ion binding]; other site 471852001216 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 471852001217 FAD binding pocket [chemical binding]; other site 471852001218 conserved FAD binding motif [chemical binding]; other site 471852001219 phosphate binding motif [ion binding]; other site 471852001220 beta-alpha-beta structure motif; other site 471852001221 NAD binding pocket [chemical binding]; other site 471852001222 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 471852001223 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852001224 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471852001225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852001226 Bacterial transcriptional regulator; Region: IclR; pfam01614 471852001227 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852001228 Bacterial transcriptional regulator; Region: IclR; pfam01614 471852001229 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471852001230 acetaldehyde dehydrogenase; Validated; Region: PRK08300 471852001231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852001232 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 471852001233 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 471852001234 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 471852001235 active site 471852001236 catalytic residues [active] 471852001237 metal binding site [ion binding]; metal-binding site 471852001238 DmpG-like communication domain; Region: DmpG_comm; pfam07836 471852001239 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471852001240 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 471852001241 active site 1 [active] 471852001242 dimer interface [polypeptide binding]; other site 471852001243 hexamer interface [polypeptide binding]; other site 471852001244 active site 2 [active] 471852001245 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471852001246 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 471852001247 NAD binding site [chemical binding]; other site 471852001248 catalytic residues [active] 471852001249 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 471852001250 acyl-coenzyme A oxidase; Region: PLN02526 471852001251 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852001252 active site 471852001253 PspC domain; Region: PspC; cl00864 471852001254 H+ Antiporter protein; Region: 2A0121; TIGR00900 471852001255 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 471852001256 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471852001257 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471852001258 active site 471852001259 metal binding site [ion binding]; metal-binding site 471852001260 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 471852001261 putative metal binding site [ion binding]; other site 471852001262 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 471852001263 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 471852001264 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471852001265 active site 471852001266 HIGH motif; other site 471852001267 nucleotide binding site [chemical binding]; other site 471852001268 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471852001269 active site 471852001270 KMSKS motif; other site 471852001271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852001272 S-adenosylmethionine binding site [chemical binding]; other site 471852001273 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 471852001274 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 471852001275 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 471852001276 acyl-CoA synthetase; Validated; Region: PRK07788 471852001277 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852001278 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 471852001279 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 471852001280 intrachain domain interface; other site 471852001281 interchain domain interface [polypeptide binding]; other site 471852001282 heme bL binding site [chemical binding]; other site 471852001283 heme bH binding site [chemical binding]; other site 471852001284 Qo binding site; other site 471852001285 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 471852001286 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 471852001287 active site 471852001288 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852001289 Rubredoxin [Energy production and conversion]; Region: COG1773 471852001290 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 471852001291 iron binding site [ion binding]; other site 471852001292 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 471852001293 Di-iron ligands [ion binding]; other site 471852001294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852001295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852001296 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 471852001297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852001298 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 471852001299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852001300 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 471852001301 RNA binding site [nucleotide binding]; other site 471852001302 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 471852001303 NlpC/P60 family; Region: NLPC_P60; cl11438 471852001304 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 471852001305 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471852001306 active site 471852001307 metal binding site [ion binding]; metal-binding site 471852001308 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 471852001309 short chain dehydrogenase; Provisional; Region: PRK06701 471852001310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852001311 NAD(P) binding site [chemical binding]; other site 471852001312 active site 471852001313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852001314 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471852001315 NAD(P) binding site [chemical binding]; other site 471852001316 active site 471852001317 enoyl-CoA hydratase; Provisional; Region: PRK08252 471852001318 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852001319 substrate binding site [chemical binding]; other site 471852001320 oxyanion hole (OAH) forming residues; other site 471852001321 trimer interface [polypeptide binding]; other site 471852001322 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471852001323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852001324 active site 471852001325 phosphorylation site [posttranslational modification] 471852001326 intermolecular recognition site; other site 471852001327 dimerization interface [polypeptide binding]; other site 471852001328 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471852001329 DNA binding site [nucleotide binding] 471852001330 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 471852001331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471852001332 dimer interface [polypeptide binding]; other site 471852001333 phosphorylation site [posttranslational modification] 471852001334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852001335 ATP binding site [chemical binding]; other site 471852001336 Mg2+ binding site [ion binding]; other site 471852001337 G-X-G motif; other site 471852001338 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471852001339 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 471852001340 RF-1 domain; Region: RF-1; cl02875 471852001341 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 471852001342 active site 471852001343 catalytic residues [active] 471852001344 metal binding site [ion binding]; metal-binding site 471852001345 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 471852001346 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 471852001347 trimer interface [polypeptide binding]; other site 471852001348 putative metal binding site [ion binding]; other site 471852001349 stage V sporulation protein K; Region: spore_V_K; TIGR02881 471852001350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852001351 Walker A motif; other site 471852001352 ATP binding site [chemical binding]; other site 471852001353 Walker B motif; other site 471852001354 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 471852001355 Phosphate transporter family; Region: PHO4; cl00396 471852001356 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 471852001357 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 471852001358 Walker A/P-loop; other site 471852001359 ATP binding site [chemical binding]; other site 471852001360 Q-loop/lid; other site 471852001361 ABC transporter signature motif; other site 471852001362 Walker B; other site 471852001363 D-loop; other site 471852001364 H-loop/switch region; other site 471852001365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852001366 dimer interface [polypeptide binding]; other site 471852001367 conserved gate region; other site 471852001368 putative PBP binding loops; other site 471852001369 ABC-ATPase subunit interface; other site 471852001370 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 471852001371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852001372 dimer interface [polypeptide binding]; other site 471852001373 conserved gate region; other site 471852001374 putative PBP binding loops; other site 471852001375 ABC-ATPase subunit interface; other site 471852001376 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471852001377 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 471852001378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471852001379 Coenzyme A binding pocket [chemical binding]; other site 471852001380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471852001381 DNA binding site [nucleotide binding] 471852001382 Ubiquitin-like proteins; Region: UBQ; cl00155 471852001383 charged pocket; other site 471852001384 hydrophobic patch; other site 471852001385 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 471852001386 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852001387 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852001388 DNA binding residues [nucleotide binding] 471852001389 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471852001390 catalytic residues [active] 471852001391 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 471852001392 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 471852001393 active site residue [active] 471852001394 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 471852001395 active site residue [active] 471852001396 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 471852001397 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 471852001398 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 471852001399 active site 471852001400 catalytic residues [active] 471852001401 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 471852001402 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852001403 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 471852001404 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852001405 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852001406 Protein of unknown function (DUF571); Region: DUF571; pfam04600 471852001407 Protein of unknown function (DUF690); Region: DUF690; cl04939 471852001408 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471852001409 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471852001410 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471852001411 active site 471852001412 catalytic residues [active] 471852001413 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471852001414 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471852001415 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471852001416 active site 471852001417 catalytic residues [active] 471852001418 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 471852001419 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 471852001420 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 471852001421 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852001422 active site 471852001423 ATP binding site [chemical binding]; other site 471852001424 substrate binding site [chemical binding]; other site 471852001425 activation loop (A-loop); other site 471852001426 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471852001427 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 471852001428 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852001429 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471852001430 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471852001431 active site 471852001432 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852001433 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471852001434 Sulfatase; Region: Sulfatase; cl10460 471852001435 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 471852001436 putative substrate binding site [chemical binding]; other site 471852001437 active site 471852001438 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 471852001439 Ca binding site [ion binding]; other site 471852001440 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471852001441 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471852001442 active site 471852001443 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471852001444 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 471852001445 putative ADP-binding pocket [chemical binding]; other site 471852001446 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 471852001447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852001448 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 471852001449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852001450 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471852001451 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471852001452 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 471852001453 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 471852001454 Walker A/P-loop; other site 471852001455 ATP binding site [chemical binding]; other site 471852001456 Q-loop/lid; other site 471852001457 ABC transporter signature motif; other site 471852001458 Walker B; other site 471852001459 D-loop; other site 471852001460 H-loop/switch region; other site 471852001461 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471852001462 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471852001463 active site 471852001464 putative glycosyl transferase; Provisional; Region: PRK10073 471852001465 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471852001466 active site 471852001467 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 471852001468 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471852001469 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471852001470 Domain of unknown function DUF87; Region: DUF87; pfam01935 471852001471 AAA-like domain; Region: AAA_10; pfam12846 471852001472 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471852001473 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 471852001474 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 471852001475 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 471852001476 catalytic triad [active] 471852001477 Integral membrane protein TerC family; Region: TerC; cl10468 471852001478 DsrE/DsrF-like family; Region: DrsE; cl00672 471852001479 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 471852001480 heme-binding site [chemical binding]; other site 471852001481 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471852001482 metal binding site 2 [ion binding]; metal-binding site 471852001483 putative DNA binding helix; other site 471852001484 metal binding site 1 [ion binding]; metal-binding site 471852001485 dimer interface [polypeptide binding]; other site 471852001486 structural Zn2+ binding site [ion binding]; other site 471852001487 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 471852001488 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 471852001489 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471852001490 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cl00253 471852001491 dimerization interface [polypeptide binding]; other site 471852001492 putative tRNAtyr binding site [nucleotide binding]; other site 471852001493 putative active site [active] 471852001494 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 471852001495 L-asparaginase II; Region: Asparaginase_II; cl01842 471852001496 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 471852001497 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 471852001498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471852001499 non-specific DNA binding site [nucleotide binding]; other site 471852001500 salt bridge; other site 471852001501 sequence-specific DNA binding site [nucleotide binding]; other site 471852001502 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 471852001503 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 471852001504 active site 471852001505 catalytic triad [active] 471852001506 oxyanion hole [active] 471852001507 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 471852001508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852001509 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471852001510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852001511 Flavoprotein; Region: Flavoprotein; cl08021 471852001512 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852001513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852001514 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471852001515 active site 471852001516 metal binding site [ion binding]; metal-binding site 471852001517 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471852001518 sequence-specific DNA binding site [nucleotide binding]; other site 471852001519 salt bridge; other site 471852001520 AzlC protein; Region: AzlC; cl00570 471852001521 Leucine carboxyl methyltransferase; Region: LCM; cl01306 471852001522 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852001523 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471852001524 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852001525 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 471852001526 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 471852001527 putative active site [active] 471852001528 metal binding site [ion binding]; metal-binding site 471852001529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852001530 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471852001531 NAD(P) binding site [chemical binding]; other site 471852001532 active site 471852001533 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 471852001534 putative ADP-ribose binding site [chemical binding]; other site 471852001535 putative active site [active] 471852001536 TIGR03084 family protein; Region: TIGR03084 471852001537 DinB superfamily; Region: DinB_2; cl00986 471852001538 acyl-CoA synthetase; Validated; Region: PRK07798 471852001539 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852001540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852001541 NAD(P) binding site [chemical binding]; other site 471852001542 active site 471852001543 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 471852001544 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 471852001545 putative ADP-binding pocket [chemical binding]; other site 471852001546 Protein of unknown function (DUF2596); Region: DUF2596; pfam10770 471852001547 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471852001548 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471852001549 catalytic core [active] 471852001550 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 471852001551 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 471852001552 PhoU domain; Region: PhoU; pfam01895 471852001553 PhoU domain; Region: PhoU; pfam01895 471852001554 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 471852001555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471852001556 dimer interface [polypeptide binding]; other site 471852001557 phosphorylation site [posttranslational modification] 471852001558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852001559 ATP binding site [chemical binding]; other site 471852001560 Mg2+ binding site [ion binding]; other site 471852001561 G-X-G motif; other site 471852001562 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471852001563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852001564 active site 471852001565 phosphorylation site [posttranslational modification] 471852001566 intermolecular recognition site; other site 471852001567 dimerization interface [polypeptide binding]; other site 471852001568 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471852001569 DNA binding site [nucleotide binding] 471852001570 Protein of unknown function (DUF461); Region: DUF461; cl01071 471852001571 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 471852001572 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cl10030 471852001573 homotrimer interaction site [polypeptide binding]; other site 471852001574 zinc binding site [ion binding]; other site 471852001575 CDP-binding sites; other site 471852001576 FOG: CBS domain [General function prediction only]; Region: COG0517 471852001577 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 471852001578 fumarylacetoacetase; Region: PLN02856 471852001579 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 471852001580 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471852001581 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 471852001582 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 471852001583 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 471852001584 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471852001585 active site 471852001586 HIGH motif; other site 471852001587 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471852001588 KMSKS motif; other site 471852001589 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471852001590 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471852001591 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 471852001592 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471852001593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852001594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852001595 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852001596 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471852001597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852001598 DNA-binding site [nucleotide binding]; DNA binding site 471852001599 UTRA domain; Region: UTRA; cl01230 471852001600 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852001601 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; Region: SUA7; COG1405 471852001602 UTRA domain; Region: UTRA; cl01230 471852001603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852001604 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270 471852001605 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471852001606 putative NAD(P) binding site [chemical binding]; other site 471852001607 AMP-binding domain protein; Validated; Region: PRK07529 471852001608 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852001609 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471852001610 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 471852001611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852001612 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471852001613 active site 471852001614 metal binding site [ion binding]; metal-binding site 471852001615 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 471852001616 putative active site [active] 471852001617 putative metal binding site [ion binding]; other site 471852001618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852001619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852001620 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 471852001621 FAD binding domain; Region: FAD_binding_4; pfam01565 471852001622 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 471852001623 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 471852001624 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 471852001625 active site 471852001626 NAD binding site [chemical binding]; other site 471852001627 metal binding site [ion binding]; metal-binding site 471852001628 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 471852001629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852001630 ATP binding site [chemical binding]; other site 471852001631 putative Mg++ binding site [ion binding]; other site 471852001632 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852001633 nucleotide binding region [chemical binding]; other site 471852001634 ATP-binding site [chemical binding]; other site 471852001635 RQC domain; Region: RQC; cl09632 471852001636 HRDC domain; Region: HRDC; cl02578 471852001637 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 471852001638 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 471852001639 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 471852001640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852001641 Predicted ATPase [General function prediction only]; Region: COG3899 471852001642 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 471852001643 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 471852001644 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 471852001645 Predicted ATPase [General function prediction only]; Region: COG3899 471852001646 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 471852001647 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 471852001648 DNA binding residues [nucleotide binding] 471852001649 putative dimer interface [polypeptide binding]; other site 471852001650 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471852001651 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 471852001652 active site 471852001653 catalytic tetrad [active] 471852001654 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471852001655 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852001656 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471852001657 Walker A/P-loop; other site 471852001658 ATP binding site [chemical binding]; other site 471852001659 Q-loop/lid; other site 471852001660 ABC transporter signature motif; other site 471852001661 Walker B; other site 471852001662 D-loop; other site 471852001663 H-loop/switch region; other site 471852001664 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471852001665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852001666 S-adenosylmethionine binding site [chemical binding]; other site 471852001667 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 471852001668 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 471852001669 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 471852001670 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 471852001671 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471852001672 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471852001673 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 471852001674 TM-ABC transporter signature motif; other site 471852001675 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 471852001676 TM-ABC transporter signature motif; other site 471852001677 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 471852001678 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 471852001679 Walker A/P-loop; other site 471852001680 ATP binding site [chemical binding]; other site 471852001681 Q-loop/lid; other site 471852001682 ABC transporter signature motif; other site 471852001683 Walker B; other site 471852001684 D-loop; other site 471852001685 H-loop/switch region; other site 471852001686 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 471852001687 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 471852001688 Walker A/P-loop; other site 471852001689 ATP binding site [chemical binding]; other site 471852001690 Q-loop/lid; other site 471852001691 ABC transporter signature motif; other site 471852001692 Walker B; other site 471852001693 D-loop; other site 471852001694 H-loop/switch region; other site 471852001695 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471852001696 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 471852001697 hypothetical protein; Provisional; Region: PRK07877 471852001698 dimer interface [polypeptide binding]; other site 471852001699 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 471852001700 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471852001701 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852001702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852001703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852001704 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 471852001705 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471852001706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852001707 DNA-binding site [nucleotide binding]; DNA binding site 471852001708 UTRA domain; Region: UTRA; cl01230 471852001709 malonyl-CoA synthase; Validated; Region: PRK07514 471852001710 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852001711 Lsr2; Region: Lsr2; pfam11774 471852001712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852001713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852001714 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 471852001715 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852001716 substrate binding site [chemical binding]; other site 471852001717 oxyanion hole (OAH) forming residues; other site 471852001718 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852001719 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471852001720 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471852001721 active site 471852001722 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 471852001723 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852001724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852001725 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471852001726 NAD(P) binding site [chemical binding]; other site 471852001727 active site 471852001728 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471852001729 dimerization interface [polypeptide binding]; other site 471852001730 putative DNA binding site [nucleotide binding]; other site 471852001731 putative Zn2+ binding site [ion binding]; other site 471852001732 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 471852001733 putative hydrophobic ligand binding site [chemical binding]; other site 471852001734 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 471852001735 Zc3h12a-like Ribonuclease NYN domain; Region: RNase_Zc3h12a; pfam11977 471852001736 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 471852001737 structural tetrad; other site 471852001738 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine...; Region: URO-D_CIMS_like; cl00464 471852001739 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 471852001740 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 471852001741 active site 471852001742 catalytic residues [active] 471852001743 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 471852001744 Uncharacterized conserved protein [Function unknown]; Region: COG1912 471852001745 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 471852001746 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 471852001747 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471852001748 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852001749 active site 471852001750 ATP binding site [chemical binding]; other site 471852001751 substrate binding site [chemical binding]; other site 471852001752 activation loop (A-loop); other site 471852001753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852001754 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852001755 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852001756 active site 471852001757 ATP binding site [chemical binding]; other site 471852001758 substrate binding site [chemical binding]; other site 471852001759 activation loop (A-loop); other site 471852001760 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 471852001761 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852001762 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852001763 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 471852001764 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 471852001765 active site 471852001766 homotetramer interface [polypeptide binding]; other site 471852001767 threonine synthase; Validated; Region: PRK07591 471852001768 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 471852001769 homodimer interface [polypeptide binding]; other site 471852001770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852001771 catalytic residue [active] 471852001772 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 471852001773 MoaE interaction surface [polypeptide binding]; other site 471852001774 MoeB interaction surface [polypeptide binding]; other site 471852001775 thiocarboxylated glycine; other site 471852001776 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 471852001777 DNA-binding site [nucleotide binding]; DNA binding site 471852001778 RNA-binding motif; other site 471852001779 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471852001780 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 471852001781 ring oligomerisation interface [polypeptide binding]; other site 471852001782 ATP/Mg binding site [chemical binding]; other site 471852001783 stacking interactions; other site 471852001784 hinge regions; other site 471852001785 Scramblase; Region: Scramblase; cl02043 471852001786 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 471852001787 putative active site; other site 471852001788 putative triphosphate binding site [ion binding]; other site 471852001789 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 471852001790 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852001791 ATP binding site [chemical binding]; other site 471852001792 putative Mg++ binding site [ion binding]; other site 471852001793 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852001794 nucleotide binding region [chemical binding]; other site 471852001795 ATP-binding site [chemical binding]; other site 471852001796 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 471852001797 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471852001798 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852001799 TROVE domain; Region: TROVE; pfam05731 471852001800 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471852001801 metal ion-dependent adhesion site (MIDAS); other site 471852001802 Predicted transcriptional regulator [Transcription]; Region: COG2378 471852001803 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 471852001804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471852001805 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 471852001806 DNA-binding site [nucleotide binding]; DNA binding site 471852001807 RNA-binding motif; other site 471852001808 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 471852001809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852001810 H+ Antiporter protein; Region: 2A0121; TIGR00900 471852001811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852001812 putative substrate translocation pore; other site 471852001813 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 471852001814 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 471852001815 putative metal binding site [ion binding]; other site 471852001816 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 471852001817 putative metal binding site [ion binding]; other site 471852001818 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 471852001819 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 471852001820 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471852001821 Phd_YefM; Region: PhdYeFM; cl09153 471852001822 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 471852001823 active site 471852001824 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471852001825 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 471852001826 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471852001827 catalytic residue [active] 471852001828 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 471852001829 Citrate synthase; Region: Citrate_synt; pfam00285 471852001830 oxalacetate binding site [chemical binding]; other site 471852001831 citrylCoA binding site [chemical binding]; other site 471852001832 coenzyme A binding site [chemical binding]; other site 471852001833 catalytic triad [active] 471852001834 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 471852001835 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471852001836 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 471852001837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852001838 putative substrate translocation pore; other site 471852001839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852001840 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 471852001841 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471852001842 FeoA domain; Region: FeoA; cl00838 471852001843 PAS fold; Region: PAS_4; pfam08448 471852001844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471852001845 putative active site [active] 471852001846 heme pocket [chemical binding]; other site 471852001847 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471852001848 GAF domain; Region: GAF; cl00853 471852001849 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471852001850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852001851 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 471852001852 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471852001853 dimer interface [polypeptide binding]; other site 471852001854 active site 471852001855 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 471852001856 putative dimer interface [polypeptide binding]; other site 471852001857 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471852001858 DNA binding residues [nucleotide binding] 471852001859 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852001860 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852001861 active site 471852001862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852001863 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471852001864 Bacterial transcriptional regulator; Region: IclR; pfam01614 471852001865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852001866 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 471852001867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 471852001868 TPR motif; other site 471852001869 binding surface 471852001870 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852001871 DNA binding residues [nucleotide binding] 471852001872 dimerization interface [polypeptide binding]; other site 471852001873 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852001874 Leucine carboxyl methyltransferase; Region: LCM; cl01306 471852001875 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 471852001876 intersubunit interface [polypeptide binding]; other site 471852001877 active site 471852001878 catalytic residue [active] 471852001879 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 471852001880 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 471852001881 NAD(P) binding site [chemical binding]; other site 471852001882 catalytic residues [active] 471852001883 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471852001884 NAD(P) binding site [chemical binding]; other site 471852001885 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 471852001886 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 471852001887 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471852001888 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 471852001889 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 471852001890 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 471852001891 substrate binding site [chemical binding]; other site 471852001892 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 471852001893 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471852001894 Walker A/P-loop; other site 471852001895 ATP binding site [chemical binding]; other site 471852001896 Q-loop/lid; other site 471852001897 ABC transporter signature motif; other site 471852001898 Walker B; other site 471852001899 D-loop; other site 471852001900 H-loop/switch region; other site 471852001901 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471852001902 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 471852001903 prolyl-tRNA synthetase; Provisional; Region: PRK08661 471852001904 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_arch_euk; cd00778 471852001905 dimer interface [polypeptide binding]; other site 471852001906 motif 1; other site 471852001907 active site 471852001908 motif 2; other site 471852001909 motif 3; other site 471852001910 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity...; Region: ProRS_anticodon_zinc; cd00862 471852001911 anticodon binding site; other site 471852001912 zinc-binding site [ion binding]; other site 471852001913 PAS fold; Region: PAS; pfam00989 471852001914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471852001915 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 471852001916 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471852001917 ANTAR domain; Region: ANTAR; cl04297 471852001918 Subtilisin inhibitor-like; Region: SSI; cl11594 471852001919 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 471852001920 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852001921 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852001922 DNA binding residues [nucleotide binding] 471852001923 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 471852001924 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471852001925 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471852001926 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471852001927 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471852001928 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471852001929 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471852001930 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471852001931 anti sigma factor interaction site; other site 471852001932 regulatory phosphorylation site [posttranslational modification]; other site 471852001933 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 471852001934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852001935 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852001936 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 471852001937 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852001938 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852001939 NAD(P) binding site [chemical binding]; other site 471852001940 active site 471852001941 GAF domain; Region: GAF; cl00853 471852001942 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852001943 dimerization interface [polypeptide binding]; other site 471852001944 DNA binding residues [nucleotide binding] 471852001945 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 471852001946 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852001947 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852001948 Global regulator protein family; Region: CsrA; cl00670 471852001949 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 471852001950 putative heme binding site [chemical binding]; other site 471852001951 putative substrate binding site [chemical binding]; other site 471852001952 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 471852001953 active site 471852001954 LysE type translocator; Region: LysE; cl00565 471852001955 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471852001956 Domain of unknown function (DUF371); Region: DUF371; cl00916 471852001957 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 471852001958 active site 471852001959 dimerization interface [polypeptide binding]; other site 471852001960 Phage integrase family; Region: Phage_integrase; pfam00589 471852001961 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471852001962 DNA binding site [nucleotide binding] 471852001963 active site 471852001964 Int/Topo IB signature motif; other site 471852001965 PAC2 family; Region: PAC2; cl00847 471852001966 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 471852001967 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 471852001968 SAF domain; Region: SAF; cl00555 471852001969 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 471852001970 Transport protein; Region: actII; TIGR00833 471852001971 Transport protein; Region: actII; TIGR00833 471852001972 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 471852001973 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 471852001974 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 471852001975 active site 471852001976 tetramer interface [polypeptide binding]; other site 471852001977 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471852001978 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471852001979 dimer interface [polypeptide binding]; other site 471852001980 putative functional site; other site 471852001981 putative MPT binding site; other site 471852001982 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 471852001983 trimer interface [polypeptide binding]; other site 471852001984 dimer interface [polypeptide binding]; other site 471852001985 putative active site [active] 471852001986 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 471852001987 MPT binding site; other site 471852001988 trimer interface [polypeptide binding]; other site 471852001989 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852001990 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471852001991 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 471852001992 aromatic arch; other site 471852001993 DCoH dimer interaction site [polypeptide binding]; other site 471852001994 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 471852001995 DCoH tetramer interaction site [polypeptide binding]; other site 471852001996 substrate binding site [chemical binding]; other site 471852001997 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13943 471852001998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852001999 S-adenosylmethionine binding site [chemical binding]; other site 471852002000 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471852002001 dimer interface [polypeptide binding]; other site 471852002002 ssDNA binding site [nucleotide binding]; other site 471852002003 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471852002004 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 471852002005 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 471852002006 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 471852002007 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 471852002008 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471852002009 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852002010 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471852002011 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 471852002012 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 471852002013 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 471852002014 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852002015 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 471852002016 ParB-like nuclease domain; Region: ParBc; cl02129 471852002017 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 471852002018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852002019 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 471852002020 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 471852002021 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 471852002022 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 471852002023 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 471852002024 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 471852002025 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 471852002026 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 471852002027 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 471852002028 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 471852002029 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471852002030 Dienelactone hydrolase family; Region: DLH; pfam01738 471852002031 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852002032 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 471852002033 SpoOM protein; Region: Spo0M; pfam07070 471852002034 CoA-transferase family III; Region: CoA_transf_3; cl00778 471852002035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852002036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852002037 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 471852002038 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 471852002039 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852002040 active site 471852002041 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 471852002042 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471852002043 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471852002044 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852002045 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471852002046 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852002047 active site 471852002048 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 471852002049 active site 471852002050 catalytic residues [active] 471852002051 metal binding site [ion binding]; metal-binding site 471852002052 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471852002053 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471852002054 catalytic core [active] 471852002055 Ion transport protein; Region: Ion_trans; pfam00520 471852002056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852002057 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 471852002058 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 471852002059 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 471852002060 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 471852002061 Predicted methyltransferases [General function prediction only]; Region: COG0313 471852002062 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471852002063 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 471852002064 Ligand binding site [chemical binding]; other site 471852002065 Putative Catalytic site [active] 471852002066 DXD motif; other site 471852002067 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 471852002068 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 471852002069 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 471852002070 active site 471852002071 HIGH motif; other site 471852002072 KMSKS motif; other site 471852002073 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 471852002074 tRNA binding surface [nucleotide binding]; other site 471852002075 anticodon binding site; other site 471852002076 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 471852002077 active site 471852002078 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471852002079 G5 domain; Region: G5; pfam07501 471852002080 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 471852002081 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471852002082 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852002083 DNA binding residues [nucleotide binding] 471852002084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852002085 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 471852002086 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 471852002087 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471852002088 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 471852002089 ABC transporter; Region: ABC_tran_2; pfam12848 471852002090 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 471852002091 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852002092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852002093 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 471852002094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852002095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852002096 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 471852002097 Di-iron ligands [ion binding]; other site 471852002098 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 471852002099 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 471852002100 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 471852002101 Substrate binding site [chemical binding]; other site 471852002102 Mg++ binding site [ion binding]; other site 471852002103 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 471852002104 active site 471852002105 substrate binding site [chemical binding]; other site 471852002106 CoA binding site [chemical binding]; other site 471852002107 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 471852002108 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471852002109 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 471852002110 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 471852002111 5S rRNA interface [nucleotide binding]; other site 471852002112 CTC domain interface [polypeptide binding]; other site 471852002113 L16 interface [polypeptide binding]; other site 471852002114 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 471852002115 putative active site [active] 471852002116 catalytic residue [active] 471852002117 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 471852002118 Bacterial sugar transferase; Region: Bac_transf; cl00939 471852002119 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 471852002120 active site 471852002121 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 471852002122 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 471852002123 Active Sites [active] 471852002124 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 471852002125 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 471852002126 CysD dimerization site [polypeptide binding]; other site 471852002127 G1 box; other site 471852002128 putative GEF interaction site [polypeptide binding]; other site 471852002129 GTP/Mg2+ binding site [chemical binding]; other site 471852002130 Switch I region; other site 471852002131 G2 box; other site 471852002132 G3 box; other site 471852002133 Switch II region; other site 471852002134 G4 box; other site 471852002135 G5 box; other site 471852002136 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 471852002137 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 471852002138 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471852002139 active site 471852002140 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 471852002141 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 471852002142 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 471852002143 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 471852002144 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 471852002145 ParB-like nuclease domain; Region: ParBc; cl02129 471852002146 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 471852002147 Chain length determinant protein; Region: Wzz; cl01623 471852002148 exopolysaccharide/PEPCTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 471852002149 Chain length determinant protein; Region: Wzz; cl01623 471852002150 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 471852002151 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 471852002152 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 471852002153 Core-2/I-Branching enzyme; Region: Branch; pfam02485 471852002154 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 471852002155 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 471852002156 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 471852002157 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 471852002158 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471852002159 active site 471852002160 nucleotide binding site [chemical binding]; other site 471852002161 HIGH motif; other site 471852002162 KMSKS motif; other site 471852002163 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 471852002164 ligand-binding site [chemical binding]; other site 471852002165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852002166 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 471852002167 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 471852002168 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852002169 ATP binding site [chemical binding]; other site 471852002170 putative Mg++ binding site [ion binding]; other site 471852002171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852002172 nucleotide binding region [chemical binding]; other site 471852002173 ATP-binding site [chemical binding]; other site 471852002174 TRCF domain; Region: TRCF; cl04088 471852002175 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 471852002176 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 471852002177 Transglycosylase; Region: Transgly; cl07896 471852002178 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471852002179 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 471852002180 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 471852002181 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471852002182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852002183 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 471852002184 B12 binding site [chemical binding]; other site 471852002185 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852002186 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of methylmalonyl-; Region: MM_CoA_mutase; cl00817 471852002187 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 471852002188 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 471852002189 intersubunit interface [polypeptide binding]; other site 471852002190 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 471852002191 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 471852002192 catalytic Zn binding site [ion binding]; other site 471852002193 NAD binding site [chemical binding]; other site 471852002194 structural Zn binding site [ion binding]; other site 471852002195 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471852002196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 471852002197 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471852002198 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 471852002199 Walker A/P-loop; other site 471852002200 ATP binding site [chemical binding]; other site 471852002201 Q-loop/lid; other site 471852002202 ABC transporter signature motif; other site 471852002203 Walker B; other site 471852002204 D-loop; other site 471852002205 H-loop/switch region; other site 471852002206 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 471852002207 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 471852002208 enolase; Provisional; Region: eno; PRK00077 471852002209 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 471852002210 dimer interface [polypeptide binding]; other site 471852002211 metal binding site [ion binding]; metal-binding site 471852002212 substrate binding pocket [chemical binding]; other site 471852002213 Protein of unknown function (DUF501); Region: DUF501; cl00652 471852002214 exopolyphosphatase; Region: exo_poly_only; TIGR03706 471852002215 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 471852002216 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 471852002217 Fe-S cluster binding site [ion binding]; other site 471852002218 DNA binding site [nucleotide binding] 471852002219 active site 471852002220 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471852002221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852002222 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 471852002223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852002224 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 471852002225 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 471852002226 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471852002227 dimer interface [polypeptide binding]; other site 471852002228 active site 471852002229 FOG: WD40-like repeat [Function unknown]; Region: COG1520 471852002230 FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it turn are loaded onto the acyl...; Region: FeeA_FeeB_like; cd01836 471852002231 active site 471852002232 catalytic triad [active] 471852002233 oxyanion hole [active] 471852002234 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 471852002235 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 471852002236 dimer interface [polypeptide binding]; other site 471852002237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852002238 catalytic residue [active] 471852002239 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as...; Region: CBS_pair_PALP_assoc2; cd04609 471852002240 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471852002241 cystathionine gamma-synthase; Provisional; Region: PRK07811 471852002242 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471852002243 homodimer interface [polypeptide binding]; other site 471852002244 substrate-cofactor binding pocket; other site 471852002245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852002246 catalytic residue [active] 471852002247 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852002248 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471852002249 substrate binding pocket [chemical binding]; other site 471852002250 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 471852002251 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471852002252 metal ion-dependent adhesion site (MIDAS); other site 471852002253 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 471852002254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852002255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 471852002256 FIST N domain; Region: FIST; cl10701 471852002257 FIST C domain; Region: FIST_C; pfam10442 471852002258 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471852002259 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471852002260 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471852002261 threonine dehydratase; Provisional; Region: PRK08198 471852002262 tetramer interface [polypeptide binding]; other site 471852002263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852002264 catalytic residue [active] 471852002265 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 471852002266 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 471852002267 Zn binding site [ion binding]; other site 471852002268 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 471852002269 Zn binding site [ion binding]; other site 471852002270 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 471852002271 Zn binding site [ion binding]; other site 471852002272 RDD family; Region: RDD; cl00746 471852002273 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 471852002274 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 471852002275 dimer interface [polypeptide binding]; other site 471852002276 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 471852002277 active site 471852002278 Fe binding site [ion binding]; other site 471852002279 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471852002280 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852002281 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 471852002282 domain; Region: GreA_GreB_N; pfam03449 471852002283 C-term; Region: GreA_GreB; pfam01272 471852002284 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471852002285 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 471852002286 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471852002287 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852002288 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 471852002289 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein...; Region: SSP411; cd02955 471852002290 catalytic residues [active] 471852002291 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 471852002292 NlpC/P60 family; Region: NLPC_P60; cl11438 471852002293 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 471852002294 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 471852002295 catalytic residue [active] 471852002296 putative FPP diphosphate binding site; other site 471852002297 putative FPP binding hydrophobic cleft; other site 471852002298 dimer interface [polypeptide binding]; other site 471852002299 putative IPP diphosphate binding site; other site 471852002300 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 471852002301 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 471852002302 putative active site [active] 471852002303 PhoH-like protein; Region: PhoH; cl12134 471852002304 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 471852002305 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471852002306 catalytic residue [active] 471852002307 fumarate hydratase; Reviewed; Region: fumC; PRK00485 471852002308 Class II fumarases; Region: Fumarase_classII; cd01362 471852002309 active site 471852002310 tetramer interface [polypeptide binding]; other site 471852002311 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852002312 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852002313 active site 471852002314 ATP binding site [chemical binding]; other site 471852002315 substrate binding site [chemical binding]; other site 471852002316 activation loop (A-loop); other site 471852002317 fumarate hydratase; Provisional; Region: PRK15389 471852002318 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 471852002319 Fumarase C-terminus; Region: Fumerase_C; cl00795 471852002320 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 471852002321 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 471852002322 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 471852002323 putative active site [active] 471852002324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852002325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852002326 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 471852002327 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 471852002328 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 471852002329 generic binding surface II; other site 471852002330 generic binding surface I; other site 471852002331 LytB protein; Region: LYTB; cl00507 471852002332 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 471852002333 RmuC family; Region: RmuC; pfam02646 471852002334 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471852002335 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852002336 GTP-binding protein YchF; Reviewed; Region: PRK09601 471852002337 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 471852002338 G1 box; other site 471852002339 GTP/Mg2+ binding site [chemical binding]; other site 471852002340 Switch I region; other site 471852002341 G2 box; other site 471852002342 Switch II region; other site 471852002343 G3 box; other site 471852002344 G4 box; other site 471852002345 G5 box; other site 471852002346 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 471852002347 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 471852002348 TcpE family; Region: TcpE; pfam12648 471852002349 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 471852002350 AAA-like domain; Region: AAA_10; pfam12846 471852002351 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852002352 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 471852002353 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471852002354 catalytic residue [active] 471852002355 NlpC/P60 family; Region: NLPC_P60; cl11438 471852002356 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852002357 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852002358 active site 471852002359 ATP binding site [chemical binding]; other site 471852002360 substrate binding site [chemical binding]; other site 471852002361 activation loop (A-loop); other site 471852002362 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852002363 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 471852002364 active site 471852002365 8-oxo-dGMP binding site [chemical binding]; other site 471852002366 nudix motif; other site 471852002367 metal binding site [ion binding]; metal-binding site 471852002368 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 471852002369 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 471852002370 G1 box; other site 471852002371 putative GEF interaction site [polypeptide binding]; other site 471852002372 GTP/Mg2+ binding site [chemical binding]; other site 471852002373 Switch I region; other site 471852002374 G2 box; other site 471852002375 G3 box; other site 471852002376 Switch II region; other site 471852002377 G4 box; other site 471852002378 G5 box; other site 471852002379 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 471852002380 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 471852002381 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471852002382 phosphopeptide binding site; other site 471852002383 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 471852002384 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 471852002385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852002386 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471852002387 Walker A motif; other site 471852002388 ATP binding site [chemical binding]; other site 471852002389 Walker B motif; other site 471852002390 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471852002391 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852002392 Protein kinase domain; Region: Pkinase; pfam00069 471852002393 active site 471852002394 ATP binding site [chemical binding]; other site 471852002395 substrate binding site [chemical binding]; other site 471852002396 activation loop (A-loop); other site 471852002397 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 471852002398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852002399 domain; Region: Succ_DH_flav_C; pfam02910 471852002400 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 471852002401 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471852002402 catalytic loop [active] 471852002403 iron binding site [ion binding]; other site 471852002404 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471852002405 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 471852002406 ligand binding site [chemical binding]; other site 471852002407 flexible hinge region; other site 471852002408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852002409 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 471852002410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852002411 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471852002412 dimerization interface [polypeptide binding]; other site 471852002413 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 471852002414 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 471852002415 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 471852002416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852002417 domain; Region: Succ_DH_flav_C; pfam02910 471852002418 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 471852002419 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 471852002420 putative Iron-sulfur protein interface [polypeptide binding]; other site 471852002421 proximal heme binding site [chemical binding]; other site 471852002422 distal heme binding site [chemical binding]; other site 471852002423 putative dimer interface [polypeptide binding]; other site 471852002424 Response regulator receiver domain; Region: Response_reg; pfam00072 471852002425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852002426 active site 471852002427 phosphorylation site [posttranslational modification] 471852002428 intermolecular recognition site; other site 471852002429 dimerization interface [polypeptide binding]; other site 471852002430 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471852002431 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852002432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471852002433 dimer interface [polypeptide binding]; other site 471852002434 phosphorylation site [posttranslational modification] 471852002435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852002436 ATP binding site [chemical binding]; other site 471852002437 Mg2+ binding site [ion binding]; other site 471852002438 G-X-G motif; other site 471852002439 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 471852002440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852002441 active site 471852002442 phosphorylation site [posttranslational modification] 471852002443 intermolecular recognition site; other site 471852002444 dimerization interface [polypeptide binding]; other site 471852002445 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471852002446 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471852002447 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471852002448 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852002449 Q-loop/lid; other site 471852002450 ABC transporter signature motif; other site 471852002451 Walker B; other site 471852002452 D-loop; other site 471852002453 H-loop/switch region; other site 471852002454 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471852002455 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471852002456 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852002457 Walker A/P-loop; other site 471852002458 ATP binding site [chemical binding]; other site 471852002459 Q-loop/lid; other site 471852002460 ABC transporter signature motif; other site 471852002461 Walker B; other site 471852002462 D-loop; other site 471852002463 H-loop/switch region; other site 471852002464 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 471852002465 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852002466 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852002467 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852002468 active site 471852002469 ATP binding site [chemical binding]; other site 471852002470 substrate binding site [chemical binding]; other site 471852002471 activation loop (A-loop); other site 471852002472 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471852002473 Flavin Reductases; Region: FlaRed; cl00801 471852002474 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471852002475 Beta-lactamase; Region: Beta-lactamase; cl01009 471852002476 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 471852002477 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 471852002478 inhibitor-cofactor binding pocket; inhibition site 471852002479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852002480 catalytic residue [active] 471852002481 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471852002482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852002483 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 471852002484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852002485 S-adenosylmethionine binding site [chemical binding]; other site 471852002486 enoyl-CoA hydratase; Provisional; Region: PRK08260 471852002487 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852002488 substrate binding site [chemical binding]; other site 471852002489 oxyanion hole (OAH) forming residues; other site 471852002490 trimer interface [polypeptide binding]; other site 471852002491 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 471852002492 Ferredoxin [Energy production and conversion]; Region: COG1146 471852002493 4Fe-4S binding domain; Region: Fer4; cl02805 471852002494 hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512 471852002495 aspartate aminotransferase; Provisional; Region: PRK07681 471852002496 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471852002497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852002498 homodimer interface [polypeptide binding]; other site 471852002499 catalytic residue [active] 471852002500 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 471852002501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852002502 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 471852002503 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471852002504 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 471852002505 DNA binding residues [nucleotide binding] 471852002506 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852002507 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852002508 active site 471852002509 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852002510 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852002511 CHAT domain; Region: CHAT; cl02083 471852002512 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471852002513 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471852002514 ligand binding site [chemical binding]; other site 471852002515 flexible hinge region; other site 471852002516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852002517 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852002518 Leucine carboxyl methyltransferase; Region: LCM; cl01306 471852002519 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 471852002520 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350 471852002521 trimer interface [polypeptide binding]; other site 471852002522 active site 471852002523 substrate binding site [chemical binding]; other site 471852002524 CoA binding site [chemical binding]; other site 471852002525 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 471852002526 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 471852002527 metal binding site [ion binding]; metal-binding site 471852002528 putative dimer interface [polypeptide binding]; other site 471852002529 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 471852002530 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 471852002531 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471852002532 hydrophobic ligand binding site; other site 471852002533 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 471852002534 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 471852002535 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 471852002536 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471852002537 interface (dimer of trimers) [polypeptide binding]; other site 471852002538 Substrate-binding/catalytic site; other site 471852002539 Zn-binding sites [ion binding]; other site 471852002540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852002541 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 471852002542 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852002543 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852002544 DNA binding residues [nucleotide binding] 471852002545 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 471852002546 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 471852002547 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471852002548 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 471852002549 protein binding site [polypeptide binding]; other site 471852002550 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 471852002551 Domain of unknown function DUF59; Region: DUF59; cl00941 471852002552 antiporter inner membrane protein; Provisional; Region: PRK11670 471852002553 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 471852002554 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 471852002555 MgtE intracellular N domain; Region: MgtE_N; cl15244 471852002556 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 471852002557 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 471852002558 active site 471852002559 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 471852002560 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 471852002561 nudix motif; other site 471852002562 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852002563 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471852002564 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 471852002565 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471852002566 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 471852002567 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471852002568 ATP binding site [chemical binding]; other site 471852002569 Mg++ binding site [ion binding]; other site 471852002570 motif III; other site 471852002571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852002572 nucleotide binding region [chemical binding]; other site 471852002573 ATP-binding site [chemical binding]; other site 471852002574 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852002575 active site 471852002576 ATP binding site [chemical binding]; other site 471852002577 substrate binding site [chemical binding]; other site 471852002578 activation loop (A-loop); other site 471852002579 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 471852002580 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852002581 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852002582 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 471852002583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852002584 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 471852002585 nudix motif; other site 471852002586 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471852002587 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-...; Region: MtLigD_Pol_like; cd04863 471852002588 nucleotide binding site [chemical binding]; other site 471852002589 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 471852002590 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 471852002591 active site 471852002592 DNA binding site [nucleotide binding] 471852002593 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 471852002594 DNA binding site [nucleotide binding] 471852002595 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 471852002596 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 471852002597 putative DNA binding site [nucleotide binding]; other site 471852002598 putative homodimer interface [polypeptide binding]; other site 471852002599 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 471852002600 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 471852002601 putative ADP-binding pocket [chemical binding]; other site 471852002602 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471852002603 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471852002604 active site 471852002605 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 471852002606 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471852002607 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471852002608 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471852002609 glycerol kinase; Provisional; Region: glpK; PRK00047 471852002610 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 471852002611 N- and C-terminal domain interface [polypeptide binding]; other site 471852002612 active site 471852002613 MgATP binding site [chemical binding]; other site 471852002614 catalytic site [active] 471852002615 metal binding site [ion binding]; metal-binding site 471852002616 carbohydrate binding site [chemical binding]; other site 471852002617 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 471852002618 amphipathic channel; other site 471852002619 Asn-Pro-Ala signature motifs; other site 471852002620 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852002621 Predicted esterase [General function prediction only]; Region: COG0627 471852002622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852002623 DoxX; Region: DoxX; cl00976 471852002624 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 471852002625 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 471852002626 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 471852002627 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 471852002628 DNA binding residues [nucleotide binding] 471852002629 dimer interface [polypeptide binding]; other site 471852002630 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 471852002631 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471852002632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852002633 NAD(P) binding site [chemical binding]; other site 471852002634 active site 471852002635 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471852002636 cell division protein ZipA; Provisional; Region: PRK03427 471852002637 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 471852002638 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852002639 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852002640 active site 471852002641 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 471852002642 enoyl-CoA hydratase; Provisional; Region: PRK07827 471852002643 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852002644 substrate binding site [chemical binding]; other site 471852002645 oxyanion hole (OAH) forming residues; other site 471852002646 trimer interface [polypeptide binding]; other site 471852002647 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852002648 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852002649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471852002650 non-specific DNA binding site [nucleotide binding]; other site 471852002651 salt bridge; other site 471852002652 sequence-specific DNA binding site [nucleotide binding]; other site 471852002653 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 471852002654 IHF dimer interface [polypeptide binding]; other site 471852002655 IHF - DNA interface [nucleotide binding]; other site 471852002656 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 471852002657 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471852002658 active site 471852002659 metal binding site [ion binding]; metal-binding site 471852002660 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 471852002661 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471852002662 active site 471852002663 catalytic residues [active] 471852002664 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471852002665 catalytic residues [active] 471852002666 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 471852002667 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852002668 Putative cyclase; Region: Cyclase; cl00814 471852002669 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 471852002670 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 471852002671 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 471852002672 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471852002673 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852002674 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852002675 active site 471852002676 ATP binding site [chemical binding]; other site 471852002677 substrate binding site [chemical binding]; other site 471852002678 activation loop (A-loop); other site 471852002679 MgtE intracellular N domain; Region: MgtE_N; cl15244 471852002680 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471852002681 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852002682 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 471852002683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852002684 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852002685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 471852002686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852002687 DNA binding residues [nucleotide binding] 471852002688 dimerization interface [polypeptide binding]; other site 471852002689 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 471852002690 putative active site [active] 471852002691 putative substrate binding site [chemical binding]; other site 471852002692 catalytic site [active] 471852002693 dimer interface [polypeptide binding]; other site 471852002694 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471852002695 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471852002696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852002697 DNA-binding site [nucleotide binding]; DNA binding site 471852002698 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471852002699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852002700 homodimer interface [polypeptide binding]; other site 471852002701 catalytic residue [active] 471852002702 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 471852002703 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 471852002704 putative active site [active] 471852002705 putative substrate binding site [chemical binding]; other site 471852002706 ATP binding site [chemical binding]; other site 471852002707 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471852002708 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471852002709 metal ion-dependent adhesion site (MIDAS); other site 471852002710 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471852002711 putative catalytic site [active] 471852002712 putative metal binding site [ion binding]; other site 471852002713 putative phosphate binding site [ion binding]; other site 471852002714 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471852002715 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 471852002716 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471852002717 Transglycosylase; Region: Transgly; cl07896 471852002718 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471852002719 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 471852002720 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 471852002721 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 471852002722 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 471852002723 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 471852002724 active site 471852002725 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 471852002726 catalytic triad [active] 471852002727 dimer interface [polypeptide binding]; other site 471852002728 putative phosphoketolase; Provisional; Region: PRK05261 471852002729 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 471852002730 TPP-binding site; other site 471852002731 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 471852002732 XFP C-terminal domain; Region: XFP_C; pfam09363 471852002733 Acetokinase family; Region: Acetate_kinase; cl01029 471852002734 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 471852002735 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 471852002736 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471852002737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471852002738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471852002739 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 471852002740 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471852002741 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 471852002742 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852002743 Leucine carboxyl methyltransferase; Region: LCM; cl01306 471852002744 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471852002745 isoform II; Region: PAF-AH_p_II; pfam03403 471852002746 envelope glycoprotein H; Provisional; Region: PHA03294 471852002747 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471852002748 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 471852002749 NAD binding site [chemical binding]; other site 471852002750 catalytic Zn binding site [ion binding]; other site 471852002751 structural Zn binding site [ion binding]; other site 471852002752 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 471852002753 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 471852002754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 471852002755 CobD/Cbib protein; Region: CobD_Cbib; cl00561 471852002756 cobyric acid synthase; Provisional; Region: PRK00784 471852002757 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852002758 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 471852002759 catalytic triad [active] 471852002760 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 471852002761 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]; Region: CobN; COG1429 471852002762 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852002763 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 471852002764 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852002765 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852002766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852002767 active site 471852002768 phosphorylation site [posttranslational modification] 471852002769 intermolecular recognition site; other site 471852002770 dimerization interface [polypeptide binding]; other site 471852002771 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852002772 DNA binding residues [nucleotide binding] 471852002773 dimerization interface [polypeptide binding]; other site 471852002774 Histidine kinase; Region: HisKA_3; pfam07730 471852002775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852002776 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471852002777 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 471852002778 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852002779 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852002780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852002781 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 471852002782 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 471852002783 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852002784 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase...; Region: vWA_Magnesium_chelatase; cd01451 471852002785 metal ion-dependent adhesion site (MIDAS); other site 471852002786 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 471852002787 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 471852002788 homodimer interface [polypeptide binding]; other site 471852002789 Walker A motif; other site 471852002790 ATP binding site [chemical binding]; other site 471852002791 hydroxycobalamin binding site [chemical binding]; other site 471852002792 Walker B motif; other site 471852002793 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 471852002794 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852002795 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 471852002796 catalytic triad [active] 471852002797 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471852002798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852002799 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471852002800 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471852002801 CbiD; Region: CbiD; cl00828 471852002802 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471852002803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852002804 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 471852002805 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 471852002806 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471852002807 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 471852002808 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 471852002809 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 471852002810 Precorrin-8X methylmutase; Region: CbiC; pfam02570 471852002811 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 471852002812 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 471852002813 putative active site [active] 471852002814 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_C; cd03414 471852002815 putative active site [active] 471852002816 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471852002817 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471852002818 catalytic residue [active] 471852002819 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 471852002820 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 471852002821 putative dimer interface [polypeptide binding]; other site 471852002822 active site pocket [active] 471852002823 putative cataytic base [active] 471852002824 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 471852002825 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471852002826 GTPase RsgA; Reviewed; Region: PRK01889 471852002827 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 471852002828 G1 box; other site 471852002829 GTP/Mg2+ binding site [chemical binding]; other site 471852002830 Switch I region; other site 471852002831 G2 box; other site 471852002832 Switch II region; other site 471852002833 G3 box; other site 471852002834 G4 box; other site 471852002835 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 471852002836 G1 box; other site 471852002837 GTP/Mg2+ binding site [chemical binding]; other site 471852002838 Switch I region; other site 471852002839 G2 box; other site 471852002840 Switch II region; other site 471852002841 G3 box; other site 471852002842 G4 box; other site 471852002843 G5 box; other site 471852002844 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471852002845 dimer interface [polypeptide binding]; other site 471852002846 ssDNA binding site [nucleotide binding]; other site 471852002847 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471852002848 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471852002849 metal binding site [ion binding]; metal-binding site 471852002850 active site 471852002851 I-site; other site 471852002852 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 471852002853 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852002854 Walker A/P-loop; other site 471852002855 ATP binding site [chemical binding]; other site 471852002856 Q-loop/lid; other site 471852002857 ABC transporter signature motif; other site 471852002858 Walker B; other site 471852002859 D-loop; other site 471852002860 H-loop/switch region; other site 471852002861 ABC transporter; Region: ABC_tran_2; pfam12848 471852002862 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 471852002863 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 471852002864 active site 471852002865 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 471852002866 apolar tunnel; other site 471852002867 heme binding site [chemical binding]; other site 471852002868 dimerization interface [polypeptide binding]; other site 471852002869 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471852002870 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852002871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852002872 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 471852002873 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852002874 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 471852002875 active site 471852002876 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 471852002877 Cupin domain; Region: Cupin_2; cl09118 471852002878 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 471852002879 putative active site [active] 471852002880 catalytic site [active] 471852002881 putative metal binding site [ion binding]; other site 471852002882 Dehydratase family; Region: ILVD_EDD; cl00340 471852002883 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 471852002884 Nuclease-related domain; Region: NERD; pfam08378 471852002885 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471852002886 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 471852002887 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 471852002888 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 471852002889 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 471852002890 Zn binding site [ion binding]; other site 471852002891 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 471852002892 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 471852002893 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471852002894 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 471852002895 cobalt transport protein CbiN; Validated; Region: PRK06287 471852002896 Cobalt transport protein; Region: CbiQ; cl00463 471852002897 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471852002898 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 471852002899 Walker A/P-loop; other site 471852002900 ATP binding site [chemical binding]; other site 471852002901 Q-loop/lid; other site 471852002902 ABC transporter signature motif; other site 471852002903 Walker B; other site 471852002904 D-loop; other site 471852002905 H-loop/switch region; other site 471852002906 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 471852002907 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 471852002908 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 471852002909 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471852002910 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852002911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 471852002912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852002913 ATP binding site [chemical binding]; other site 471852002914 Mg2+ binding site [ion binding]; other site 471852002915 G-X-G motif; other site 471852002916 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471852002917 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471852002918 NAD(P) binding site [chemical binding]; other site 471852002919 catalytic residues [active] 471852002920 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 471852002921 generic binding surface II; other site 471852002922 generic binding surface I; other site 471852002923 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 471852002924 putative active site [active] 471852002925 putative catalytic site [active] 471852002926 putative Mg binding site IVb [ion binding]; other site 471852002927 putative phosphate binding site [ion binding]; other site 471852002928 putative DNA binding site [nucleotide binding]; other site 471852002929 putative Mg binding site IVa [ion binding]; other site 471852002930 Cupin domain; Region: Cupin_2; cl09118 471852002931 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471852002932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471852002933 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 471852002934 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895 471852002935 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 471852002936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852002937 putative substrate translocation pore; other site 471852002938 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471852002939 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852002940 NlpC/P60 family; Region: NLPC_P60; cl11438 471852002941 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 471852002942 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852002943 active site 471852002944 Flavin Reductases; Region: FlaRed; cl00801 471852002945 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 471852002946 active site 471852002947 iron coordination sites [ion binding]; other site 471852002948 substrate binding pocket [chemical binding]; other site 471852002949 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471852002950 active site residue [active] 471852002951 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471852002952 active site residue [active] 471852002953 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471852002954 active site residue [active] 471852002955 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471852002956 active site residue [active] 471852002957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852002958 dimer interface [polypeptide binding]; other site 471852002959 conserved gate region; other site 471852002960 putative PBP binding loops; other site 471852002961 ABC-ATPase subunit interface; other site 471852002962 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471852002963 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852002964 Walker A/P-loop; other site 471852002965 ATP binding site [chemical binding]; other site 471852002966 Q-loop/lid; other site 471852002967 ABC transporter signature motif; other site 471852002968 Walker B; other site 471852002969 D-loop; other site 471852002970 H-loop/switch region; other site 471852002971 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 471852002972 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 471852002973 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852002974 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 471852002975 active site 471852002976 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 471852002977 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 471852002978 active site 471852002979 non-prolyl cis peptide bond; other site 471852002980 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 471852002981 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471852002982 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852002983 Bacterial transcriptional regulator; Region: IclR; pfam01614 471852002984 Cupin domain; Region: Cupin_2; cl09118 471852002985 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 471852002986 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 471852002987 dimer interface [polypeptide binding]; other site 471852002988 active site 471852002989 non-prolyl cis peptide bond; other site 471852002990 insertion regions; other site 471852002991 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 471852002992 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 471852002993 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471852002994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852002995 dimer interface [polypeptide binding]; other site 471852002996 conserved gate region; other site 471852002997 ABC-ATPase subunit interface; other site 471852002998 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 471852002999 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 471852003000 substrate binding pocket [chemical binding]; other site 471852003001 membrane-bound complex binding site; other site 471852003002 hinge residues; other site 471852003003 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 471852003004 domain; Region: Succ_DH_flav_C; pfam02910 471852003005 Ferredoxin [Energy production and conversion]; Region: COG1146 471852003006 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 471852003007 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 471852003008 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 471852003009 molybdopterin cofactor binding site [chemical binding]; other site 471852003010 substrate binding site [chemical binding]; other site 471852003011 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 471852003012 molybdopterin cofactor binding site; other site 471852003013 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471852003014 active site 471852003015 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 471852003016 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 471852003017 ADP-ribose binding site [chemical binding]; other site 471852003018 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cl03075 471852003019 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 471852003020 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 471852003021 uncharacterized phage protein; Region: phage_xxxx; TIGR02642 471852003022 CHAT domain; Region: CHAT; cl02083 471852003023 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 471852003024 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471852003025 RES domain; Region: RES; cl02411 471852003026 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471852003027 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 471852003028 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852003029 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471852003030 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 471852003031 Telomeric repeat-binding factor 2; Region: TRF2; pfam11611 471852003032 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852003033 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471852003034 non-specific DNA binding site [nucleotide binding]; other site 471852003035 salt bridge; other site 471852003036 sequence-specific DNA binding site [nucleotide binding]; other site 471852003037 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 471852003038 RHS Repeat; Region: RHS_repeat; cl11982 471852003039 RHS Repeat; Region: RHS_repeat; cl11982 471852003040 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 471852003041 RHS Repeat; Region: RHS_repeat; cl11982 471852003042 RHS Repeat; Region: RHS_repeat; cl11982 471852003043 RHS Repeat; Region: RHS_repeat; cl11982 471852003044 RHS Repeat; Region: RHS_repeat; cl11982 471852003045 RHS Repeat; Region: RHS_repeat; cl11982 471852003046 RHS Repeat; Region: RHS_repeat; cl11982 471852003047 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 471852003048 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 471852003049 structural tetrad; other site 471852003050 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 471852003051 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 471852003052 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 471852003053 structural tetrad; other site 471852003054 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 471852003055 LysE type translocator; Region: LysE; cl00565 471852003056 Restriction endonuclease; Region: Mrr_cat; cl00747 471852003057 Cytochrome P450; Region: p450; cl12078 471852003058 Cytochrome P450; Region: p450; cl12078 471852003059 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852003060 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471852003061 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 471852003062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852003063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852003064 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471852003065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852003066 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 471852003067 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 471852003068 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852003069 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852003070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471852003071 salt bridge; other site 471852003072 non-specific DNA binding site [nucleotide binding]; other site 471852003073 sequence-specific DNA binding site [nucleotide binding]; other site 471852003074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852003075 putative transcriptional regulator; Provisional; Region: PRK11640 471852003076 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852003077 active site 471852003078 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471852003079 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 471852003080 Walker A/P-loop; other site 471852003081 ATP binding site [chemical binding]; other site 471852003082 Q-loop/lid; other site 471852003083 ABC transporter signature motif; other site 471852003084 Walker B; other site 471852003085 D-loop; other site 471852003086 H-loop/switch region; other site 471852003087 NMT1/THI5 like; Region: NMT1; pfam09084 471852003088 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 471852003089 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 471852003090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852003091 dimer interface [polypeptide binding]; other site 471852003092 conserved gate region; other site 471852003093 putative PBP binding loops; other site 471852003094 ABC-ATPase subunit interface; other site 471852003095 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 471852003096 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 471852003097 active site 471852003098 catalytic residues [active] 471852003099 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852003100 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 471852003101 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 471852003102 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471852003103 homodimer interface [polypeptide binding]; other site 471852003104 substrate-cofactor binding pocket; other site 471852003105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852003106 catalytic residue [active] 471852003107 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 471852003108 Radical SAM; Region: Elp3; smart00729 471852003109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471852003110 FeS/SAM binding site; other site 471852003111 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 471852003112 dimerization interface [polypeptide binding]; other site 471852003113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471852003114 dimer interface [polypeptide binding]; other site 471852003115 phosphorylation site [posttranslational modification] 471852003116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852003117 ATP binding site [chemical binding]; other site 471852003118 Mg2+ binding site [ion binding]; other site 471852003119 G-X-G motif; other site 471852003120 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 471852003121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852003122 active site 471852003123 phosphorylation site [posttranslational modification] 471852003124 intermolecular recognition site; other site 471852003125 dimerization interface [polypeptide binding]; other site 471852003126 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471852003127 DNA binding site [nucleotide binding] 471852003128 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852003129 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which...; Region: SERPIN; cl00137 471852003130 reactive center loop; other site 471852003131 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471852003132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852003133 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471852003134 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852003135 hypothetical protein; Provisional; Region: PRK06185 471852003136 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 471852003137 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471852003138 dimer interface [polypeptide binding]; other site 471852003139 active site 471852003140 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471852003141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852003142 NAD(P) binding site [chemical binding]; other site 471852003143 active site 471852003144 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 471852003145 putative active site [active] 471852003146 putative catalytic site [active] 471852003147 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 471852003148 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852003149 active site 471852003150 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852003151 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852003152 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852003153 active site 471852003154 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 471852003155 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 471852003156 Predicted ATPase [General function prediction only]; Region: COG3899 471852003157 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852003158 DNA binding residues [nucleotide binding] 471852003159 dimerization interface [polypeptide binding]; other site 471852003160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852003161 hypothetical protein; Provisional; Region: PRK06847 471852003162 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852003163 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 471852003164 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852003165 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051 471852003166 Ca2+ binding site [ion binding]; other site 471852003167 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 471852003168 TIGR02680 family protein; Region: TIGR02680 471852003169 TIGR02680 family protein; Region: TIGR02680 471852003170 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 471852003171 TIGR02677 family protein; Region: TIGR02677 471852003172 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 471852003173 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 471852003174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852003175 ATP binding site [chemical binding]; other site 471852003176 putative Mg++ binding site [ion binding]; other site 471852003177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852003178 nucleotide binding region [chemical binding]; other site 471852003179 ATP-binding site [chemical binding]; other site 471852003180 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 471852003181 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471852003182 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471852003183 metal ion-dependent adhesion site (MIDAS); other site 471852003184 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471852003185 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471852003186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852003187 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 471852003188 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 471852003189 NADP binding site [chemical binding]; other site 471852003190 Cutinase; Region: Cutinase; pfam01083 471852003191 Cutinase; Region: Cutinase; pfam01083 471852003192 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852003193 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852003194 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852003195 active site 471852003196 ATP binding site [chemical binding]; other site 471852003197 substrate binding site [chemical binding]; other site 471852003198 activation loop (A-loop); other site 471852003199 5-oxoprolinase; Region: PLN02666 471852003200 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 471852003201 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 471852003202 Cutinase; Region: Cutinase; pfam01083 471852003203 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 471852003204 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471852003205 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/...; Region: SIRT4; cd01409 471852003206 NAD+ binding site [chemical binding]; other site 471852003207 substrate binding site [chemical binding]; other site 471852003208 Zn binding site [ion binding]; other site 471852003209 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes...; Region: NADPH_oxidoreductase_1; cd02150 471852003210 putative FMN binding site [chemical binding]; other site 471852003211 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 471852003212 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471852003213 active site 471852003214 substrate binding site [chemical binding]; other site 471852003215 catalytic site [active] 471852003216 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 471852003217 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471852003218 metal ion-dependent adhesion site (MIDAS); other site 471852003219 trigger factor; Provisional; Region: tig; PRK01490 471852003220 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 471852003221 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 471852003222 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471852003223 oligomer interface [polypeptide binding]; other site 471852003224 active site residues [active] 471852003225 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471852003226 oligomer interface [polypeptide binding]; other site 471852003227 active site residues [active] 471852003228 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 471852003229 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 471852003230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852003231 Walker A motif; other site 471852003232 ATP binding site [chemical binding]; other site 471852003233 Walker B motif; other site 471852003234 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471852003235 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852003236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852003237 active site 471852003238 phosphorylation site [posttranslational modification] 471852003239 intermolecular recognition site; other site 471852003240 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852003241 DNA binding residues [nucleotide binding] 471852003242 dimerization interface [polypeptide binding]; other site 471852003243 Histidine kinase; Region: HisKA_3; pfam07730 471852003244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852003245 ATP binding site [chemical binding]; other site 471852003246 Mg2+ binding site [ion binding]; other site 471852003247 G-X-G motif; other site 471852003248 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 471852003249 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 471852003250 HIGH motif; other site 471852003251 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 471852003252 active site 471852003253 KMSKS motif; other site 471852003254 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 471852003255 tRNA binding surface [nucleotide binding]; other site 471852003256 anticodon binding site; other site 471852003257 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 471852003258 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 471852003259 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471852003260 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 471852003261 active site 471852003262 multimer interface [polypeptide binding]; other site 471852003263 rod shape-determining protein MreB; Provisional; Region: PRK13927 471852003264 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 471852003265 ATP binding site [chemical binding]; other site 471852003266 profilin binding site; other site 471852003267 rod shape-determining protein MreC; Region: MreC; pfam04085 471852003268 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 471852003269 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471852003270 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 471852003271 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 471852003272 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 471852003273 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 471852003274 B12 binding site [chemical binding]; other site 471852003275 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471852003276 FeS/SAM binding site; other site 471852003277 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 471852003278 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 471852003279 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 471852003280 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 471852003281 homodimer interface [polypeptide binding]; other site 471852003282 oligonucleotide binding site [chemical binding]; other site 471852003283 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 471852003284 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 471852003285 GTPase CgtA; Reviewed; Region: obgE; PRK12296 471852003286 GTP1/OBG; Region: GTP1_OBG; pfam01018 471852003287 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 471852003288 G1 box; other site 471852003289 GTP/Mg2+ binding site [chemical binding]; other site 471852003290 Switch I region; other site 471852003291 G2 box; other site 471852003292 G3 box; other site 471852003293 Switch II region; other site 471852003294 G4 box; other site 471852003295 G5 box; other site 471852003296 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 471852003297 gamma-glutamyl kinase; Provisional; Region: PRK05429 471852003298 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 471852003299 nucleotide binding site [chemical binding]; other site 471852003300 homotetrameric interface [polypeptide binding]; other site 471852003301 putative phosphate binding site [ion binding]; other site 471852003302 putative allosteric binding site; other site 471852003303 PUA domain; Region: PUA; cl00607 471852003304 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 471852003305 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 471852003306 putative catalytic cysteine [active] 471852003307 Peptidase family M48; Region: Peptidase_M48; cl12018 471852003308 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 471852003309 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 471852003310 active site 471852003311 (T/H)XGH motif; other site 471852003312 Domain of unknown function DUF143; Region: DUF143; cl00519 471852003313 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471852003314 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471852003315 catalytic core [active] 471852003316 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 471852003317 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471852003318 Protein of unknown function (DUF523); Region: DUF523; cl00733 471852003319 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 471852003320 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 471852003321 D-pathway; other site 471852003322 Putative ubiquinol binding site [chemical binding]; other site 471852003323 Low-spin heme (heme b) binding site [chemical binding]; other site 471852003324 Putative water exit pathway; other site 471852003325 Binuclear center (heme o3/CuB) [ion binding]; other site 471852003326 K-pathway; other site 471852003327 Putative proton exit pathway; other site 471852003328 classical (c) SDRs; Region: SDR_c; cd05233 471852003329 short chain dehydrogenase; Provisional; Region: PRK05650 471852003330 NAD(P) binding site [chemical binding]; other site 471852003331 active site 471852003332 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 471852003333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852003334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852003335 tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264 471852003336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471852003337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852003338 homodimer interface [polypeptide binding]; other site 471852003339 catalytic residue [active] 471852003340 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 471852003341 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852003342 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852003343 putative Mg++ binding site [ion binding]; other site 471852003344 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852003345 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 471852003346 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 471852003347 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 471852003348 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 471852003349 active site 471852003350 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 471852003351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 471852003352 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471852003353 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471852003354 FAD binding domain; Region: FAD_binding_4; pfam01565 471852003355 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 471852003356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852003357 S-adenosylmethionine binding site [chemical binding]; other site 471852003358 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471852003359 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852003360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852003361 FOG: CBS domain [General function prediction only]; Region: COG0517 471852003362 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622 471852003363 hypothetical protein; Provisional; Region: PRK06541 471852003364 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 471852003365 inhibitor-cofactor binding pocket; inhibition site 471852003366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852003367 catalytic residue [active] 471852003368 putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056 471852003369 Cytochrome P450; Region: p450; cl12078 471852003370 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 471852003371 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852003372 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 471852003373 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 471852003374 HIGH motif; other site 471852003375 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471852003376 active site 471852003377 KMSKS motif; other site 471852003378 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 471852003379 tRNA binding surface [nucleotide binding]; other site 471852003380 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852003381 LexA repressor; Validated; Region: PRK00215 471852003382 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 471852003383 Catalytic site [active] 471852003384 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 471852003385 ATP cone domain; Region: ATP-cone; pfam03477 471852003386 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 471852003387 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 471852003388 active site 471852003389 dimer interface [polypeptide binding]; other site 471852003390 effector binding site; other site 471852003391 replicative DNA helicase; Validated; Region: PRK07773 471852003392 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 471852003393 thioester formation/cholesterol transfer; other site 471852003394 protein-splicing catalytic site; other site 471852003395 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl09966 471852003396 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 471852003397 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 471852003398 TSCPD domain; Region: TSCPD; cl14834 471852003399 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 471852003400 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471852003401 active site 471852003402 catalytic tetrad [active] 471852003403 DoxX; Region: DoxX; cl00976 471852003404 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 471852003405 putative metal binding site [ion binding]; other site 471852003406 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 471852003407 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 471852003408 putative metal binding site [ion binding]; other site 471852003409 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 471852003410 RNA/DNA hybrid binding site [nucleotide binding]; other site 471852003411 active site 471852003412 stage V sporulation protein K; Region: spore_V_K; TIGR02881 471852003413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852003414 Walker A motif; other site 471852003415 ATP binding site [chemical binding]; other site 471852003416 Walker B motif; other site 471852003417 arginine finger; other site 471852003418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852003419 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471852003420 Walker A motif; other site 471852003421 ATP binding site [chemical binding]; other site 471852003422 Walker B motif; other site 471852003423 arginine finger; other site 471852003424 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 471852003425 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 471852003426 FAD binding pocket [chemical binding]; other site 471852003427 FAD binding motif [chemical binding]; other site 471852003428 phosphate binding motif [ion binding]; other site 471852003429 beta-alpha-beta structure motif; other site 471852003430 NAD binding pocket [chemical binding]; other site 471852003431 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 471852003432 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471852003433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852003434 Walker A motif; other site 471852003435 ATP binding site [chemical binding]; other site 471852003436 Walker B motif; other site 471852003437 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852003438 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471852003439 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 471852003440 FeS/SAM binding site; other site 471852003441 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 471852003442 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471852003443 PAS fold; Region: PAS_4; pfam08448 471852003444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471852003445 PAS fold; Region: PAS_3; pfam08447 471852003446 GAF domain; Region: GAF; cl00853 471852003447 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471852003448 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 471852003449 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471852003450 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852003451 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471852003452 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852003453 DNA binding residues [nucleotide binding] 471852003454 Protein of unknown function (DUF328); Region: DUF328; cl01143 471852003455 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 471852003456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852003457 ATP binding site [chemical binding]; other site 471852003458 Mg2+ binding site [ion binding]; other site 471852003459 G-X-G motif; other site 471852003460 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 471852003461 anchoring element; other site 471852003462 dimer interface [polypeptide binding]; other site 471852003463 ATP binding site [chemical binding]; other site 471852003464 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 471852003465 active site 471852003466 metal binding site [ion binding]; metal-binding site 471852003467 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471852003468 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 471852003469 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 471852003470 putative catalytic residue [active] 471852003471 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 471852003472 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 471852003473 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 471852003474 CAP-like domain; other site 471852003475 Active site [active] 471852003476 primary dimer interface [polypeptide binding]; other site 471852003477 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471852003478 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 471852003479 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 471852003480 putative active site [active] 471852003481 putative substrate binding site [chemical binding]; other site 471852003482 putative FMN binding site [chemical binding]; other site 471852003483 putative catalytic residues [active] 471852003484 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471852003485 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852003486 Walker A/P-loop; other site 471852003487 ATP binding site [chemical binding]; other site 471852003488 Q-loop/lid; other site 471852003489 ABC transporter signature motif; other site 471852003490 Walker B; other site 471852003491 D-loop; other site 471852003492 H-loop/switch region; other site 471852003493 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471852003494 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852003495 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 471852003496 putative dimerization interface [polypeptide binding]; other site 471852003497 serine/threonine dehydratase; Validated; Region: PRK07048 471852003498 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471852003499 tetramer interface [polypeptide binding]; other site 471852003500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852003501 catalytic residue [active] 471852003502 Histidine kinase; Region: HisKA_3; pfam07730 471852003503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852003504 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852003505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852003506 active site 471852003507 phosphorylation site [posttranslational modification] 471852003508 intermolecular recognition site; other site 471852003509 dimerization interface [polypeptide binding]; other site 471852003510 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852003511 DNA binding residues [nucleotide binding] 471852003512 dimerization interface [polypeptide binding]; other site 471852003513 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 471852003514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852003515 ATP binding site [chemical binding]; other site 471852003516 putative Mg++ binding site [ion binding]; other site 471852003517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852003518 nucleotide binding region [chemical binding]; other site 471852003519 ATP-binding site [chemical binding]; other site 471852003520 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 471852003521 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471852003522 substrate binding site [chemical binding]; other site 471852003523 ATP binding site [chemical binding]; other site 471852003524 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471852003525 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471852003526 Coenzyme A binding pocket [chemical binding]; other site 471852003527 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 471852003528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852003529 Sulfatase; Region: Sulfatase; cl10460 471852003530 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 471852003531 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 471852003532 active site residue [active] 471852003533 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 471852003534 active site residue [active] 471852003535 CHAT domain; Region: CHAT; cl02083 471852003536 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471852003537 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852003538 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471852003539 active site 471852003540 catalytic residues [active] 471852003541 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 471852003542 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 471852003543 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471852003544 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471852003545 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471852003546 dimer interface [polypeptide binding]; other site 471852003547 active site 471852003548 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852003549 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 471852003550 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471852003551 dimer interface [polypeptide binding]; other site 471852003552 active site 471852003553 CoA binding pocket [chemical binding]; other site 471852003554 Acyl transferase domain; Region: Acyl_transf_1; cl08282 471852003555 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471852003556 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471852003557 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852003558 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471852003559 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 471852003560 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 471852003561 dimer interface [polypeptide binding]; other site 471852003562 TPP-binding site [chemical binding]; other site 471852003563 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 471852003564 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 471852003565 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 471852003566 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 471852003567 dimer interface [polypeptide binding]; other site 471852003568 catalytic triad [active] 471852003569 phosphoribulokinase; Provisional; Region: PRK07429 471852003570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852003571 Active site [active] 471852003572 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852003573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852003574 active site 471852003575 phosphorylation site [posttranslational modification] 471852003576 intermolecular recognition site; other site 471852003577 dimerization interface [polypeptide binding]; other site 471852003578 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852003579 DNA binding residues [nucleotide binding] 471852003580 dimerization interface [polypeptide binding]; other site 471852003581 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471852003582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852003583 Uncharacterized conserved protein [Function unknown]; Region: COG3268 471852003584 Uncharacterized conserved protein [Function unknown]; Region: COG3268 471852003585 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471852003586 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852003587 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471852003588 dimerization interface [polypeptide binding]; other site 471852003589 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 471852003590 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 471852003591 homodimer interface [polypeptide binding]; other site 471852003592 active site 471852003593 heterodimer interface [polypeptide binding]; other site 471852003594 catalytic residue [active] 471852003595 metal binding site [ion binding]; metal-binding site 471852003596 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 471852003597 multimerization interface [polypeptide binding]; other site 471852003598 CbbX; Provisional; Region: cbbX; CHL00181 471852003599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852003600 Walker A motif; other site 471852003601 ATP binding site [chemical binding]; other site 471852003602 Walker B motif; other site 471852003603 arginine finger; other site 471852003604 PAC2 family; Region: PAC2; cl00847 471852003605 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 471852003606 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 471852003607 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852003608 Walker A/P-loop; other site 471852003609 ATP binding site [chemical binding]; other site 471852003610 Q-loop/lid; other site 471852003611 ABC transporter signature motif; other site 471852003612 Walker B; other site 471852003613 D-loop; other site 471852003614 H-loop/switch region; other site 471852003615 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 471852003616 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 471852003617 dimer interface [polypeptide binding]; other site 471852003618 catalytic triad [active] 471852003619 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471852003620 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471852003621 synthetase active site [active] 471852003622 NTP binding site [chemical binding]; other site 471852003623 metal binding site [ion binding]; metal-binding site 471852003624 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 471852003625 PhaC subunit; Region: PHA_synth_III_C; TIGR01836 471852003626 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471852003627 phosphate binding site [ion binding]; other site 471852003628 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 471852003629 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 471852003630 active site 471852003631 Acyl transferase domain; Region: Acyl_transf_1; cl08282 471852003632 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471852003633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852003634 NAD(P) binding site [chemical binding]; other site 471852003635 active site 471852003636 tryptophan synthase, beta chain; Region: PLN02618 471852003637 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 471852003638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852003639 catalytic residue [active] 471852003640 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852003641 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 471852003642 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 471852003643 RNA/DNA hybrid binding site [nucleotide binding]; other site 471852003644 active site 471852003645 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471852003646 catalytic core [active] 471852003647 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 471852003648 Putative zinc ribbon domain; Region: DUF164; pfam02591 471852003649 Uncharacterized conserved protein [Function unknown]; Region: COG0327 471852003650 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 471852003651 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 471852003652 Sulfate transporter family; Region: Sulfate_transp; cl00967 471852003653 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 471852003654 active site clefts [active] 471852003655 zinc binding site [ion binding]; other site 471852003656 dimer interface [polypeptide binding]; other site 471852003657 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 471852003658 substrate binding site [chemical binding]; other site 471852003659 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471852003660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852003661 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471852003662 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852003663 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471852003664 Walker A/P-loop; other site 471852003665 ATP binding site [chemical binding]; other site 471852003666 Q-loop/lid; other site 471852003667 ABC transporter signature motif; other site 471852003668 Walker B; other site 471852003669 D-loop; other site 471852003670 H-loop/switch region; other site 471852003671 Bacterial membrane flanked domain; Region: DUF304; cl01348 471852003672 Bacterial membrane flanked domain; Region: DUF304; cl01348 471852003673 Bacterial membrane flanked domain; Region: DUF304; cl01348 471852003674 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 471852003675 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 471852003676 FAD binding domain; Region: FAD_binding_4; pfam01565 471852003677 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 471852003678 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 471852003679 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471852003680 catalytic residue [active] 471852003681 ferrochelatase; Reviewed; Region: hemH; PRK00035 471852003682 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 471852003683 C-terminal domain interface [polypeptide binding]; other site 471852003684 active site 471852003685 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 471852003686 active site 471852003687 N-terminal domain interface [polypeptide binding]; other site 471852003688 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 471852003689 active site 471852003690 dimerization interface [polypeptide binding]; other site 471852003691 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471852003692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852003693 active site 471852003694 phosphorylation site [posttranslational modification] 471852003695 intermolecular recognition site; other site 471852003696 dimerization interface [polypeptide binding]; other site 471852003697 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471852003698 DNA binding site [nucleotide binding] 471852003699 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852003700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471852003701 dimer interface [polypeptide binding]; other site 471852003702 phosphorylation site [posttranslational modification] 471852003703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852003704 ATP binding site [chemical binding]; other site 471852003705 Mg2+ binding site [ion binding]; other site 471852003706 G-X-G motif; other site 471852003707 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852003708 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852003709 active site 471852003710 ATP binding site [chemical binding]; other site 471852003711 substrate binding site [chemical binding]; other site 471852003712 activation loop (A-loop); other site 471852003713 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 471852003714 DinB superfamily; Region: DinB_2; cl00986 471852003715 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 471852003716 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471852003717 active site 471852003718 HIGH motif; other site 471852003719 nucleotide binding site [chemical binding]; other site 471852003720 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471852003721 active site 471852003722 KMSKS motif; other site 471852003723 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 471852003724 tRNA binding surface [nucleotide binding]; other site 471852003725 anticodon binding site; other site 471852003726 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 471852003727 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471852003728 trimer interface [polypeptide binding]; other site 471852003729 active site 471852003730 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 471852003731 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 471852003732 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 471852003733 ssDNA binding site; other site 471852003734 generic binding surface II; other site 471852003735 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 471852003736 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 471852003737 Cation transport protein; Region: TrkH; cl10514 471852003738 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471852003739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852003740 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 471852003741 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471852003742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852003743 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 471852003744 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471852003745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852003746 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 471852003747 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 471852003748 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 471852003749 TRAM domain; Region: TRAM; cl01282 471852003750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852003751 transcriptional repressor DicA; Reviewed; Region: PRK09706 471852003752 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852003753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852003754 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 471852003755 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852003756 TIGR02452 family protein; Region: TIGR02452 471852003757 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 471852003758 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 471852003759 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 471852003760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852003761 S-adenosylmethionine binding site [chemical binding]; other site 471852003762 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 471852003763 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852003764 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 471852003765 active site 471852003766 metal binding site [ion binding]; metal-binding site 471852003767 phosphoglucomutase; Validated; Region: PRK07564 471852003768 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 471852003769 active site 471852003770 substrate binding site [chemical binding]; other site 471852003771 metal binding site [ion binding]; metal-binding site 471852003772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 471852003773 Phosphotransferase enzyme family; Region: APH; pfam01636 471852003774 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852003775 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 471852003776 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852003777 LysE type translocator; Region: LysE; cl00565 471852003778 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471852003779 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852003780 DNA binding residues [nucleotide binding] 471852003781 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 471852003782 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471852003783 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471852003784 DNA binding site [nucleotide binding] 471852003785 domain linker motif; other site 471852003786 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 471852003787 putative dimerization interface [polypeptide binding]; other site 471852003788 putative ligand binding site [chemical binding]; other site 471852003789 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 471852003790 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 471852003791 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471852003792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852003793 dimer interface [polypeptide binding]; other site 471852003794 conserved gate region; other site 471852003795 putative PBP binding loops; other site 471852003796 ABC-ATPase subunit interface; other site 471852003797 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471852003798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852003799 dimer interface [polypeptide binding]; other site 471852003800 putative PBP binding loops; other site 471852003801 ABC-ATPase subunit interface; other site 471852003802 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471852003803 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 471852003804 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 471852003805 Walker A/P-loop; other site 471852003806 ATP binding site [chemical binding]; other site 471852003807 Q-loop/lid; other site 471852003808 ABC transporter signature motif; other site 471852003809 Walker B; other site 471852003810 D-loop; other site 471852003811 H-loop/switch region; other site 471852003812 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 471852003813 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 471852003814 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 471852003815 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 471852003816 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471852003817 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 471852003818 Predicted membrane-associated trancriptional regulator [Transcription]; Region: COG2512 471852003819 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471852003820 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 471852003821 Dehydratase family; Region: ILVD_EDD; cl00340 471852003822 6-phosphogluconate dehydratase; Region: edd; TIGR01196 471852003823 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471852003824 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 471852003825 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 471852003826 active site 471852003827 intersubunit interface [polypeptide binding]; other site 471852003828 catalytic residue [active] 471852003829 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 471852003830 metal binding site [ion binding]; metal-binding site 471852003831 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852003832 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852003833 active site 471852003834 ATP binding site [chemical binding]; other site 471852003835 substrate binding site [chemical binding]; other site 471852003836 activation loop (A-loop); other site 471852003837 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 471852003838 structural tetrad; other site 471852003839 FOG: WD40 repeat [General function prediction only]; Region: COG2319 471852003840 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 471852003841 structural tetrad; other site 471852003842 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 471852003843 structural tetrad; other site 471852003844 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 471852003845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852003846 aconitate hydratase; Validated; Region: PRK09277 471852003847 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 471852003848 substrate binding site [chemical binding]; other site 471852003849 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 471852003850 ligand binding site [chemical binding]; other site 471852003851 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 471852003852 substrate binding site [chemical binding]; other site 471852003853 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 471852003854 Protein of unknown function (DUF677); Region: DUF677; cl09975 471852003855 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 471852003856 active site 471852003857 SUMO-1 interface [polypeptide binding]; other site 471852003858 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation...; Region: ASCH; cl01020 471852003859 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 471852003860 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and...; Region: IPP_Isomerase; cd02885 471852003861 active site 471852003862 metal binding site [ion binding]; metal-binding site 471852003863 nudix motif; other site 471852003864 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 471852003865 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 471852003866 TPP-binding site; other site 471852003867 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471852003868 PYR/PP interface [polypeptide binding]; other site 471852003869 dimer interface [polypeptide binding]; other site 471852003870 TPP binding site [chemical binding]; other site 471852003871 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471852003872 ferredoxin-NADP+ reductase; Region: PLN02852 471852003873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852003874 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 471852003875 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852003876 substrate binding site [chemical binding]; other site 471852003877 fatty oxidation complex, alpha subunit FadJ; Region: FadJ; TIGR02440 471852003878 oxyanion hole (OAH) forming residues; other site 471852003879 trimer interface [polypeptide binding]; other site 471852003880 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471852003881 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471852003882 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471852003883 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 471852003884 dimer interface [polypeptide binding]; other site 471852003885 active site 471852003886 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 471852003887 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 471852003888 putative active site [active] 471852003889 catalytic site [active] 471852003890 putative substrate binding site [chemical binding]; other site 471852003891 HRDC domain; Region: HRDC; cl02578 471852003892 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 471852003893 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 471852003894 substrate binding site [chemical binding]; other site 471852003895 active site 471852003896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852003897 Chlorite dismutase; Region: Chlor_dismutase; cl01280 471852003898 SelR domain; Region: SelR; cl00369 471852003899 PhoD-like phosphatase; Region: PhoD; pfam09423 471852003900 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471852003901 putative active site [active] 471852003902 putative metal binding site [ion binding]; other site 471852003903 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471852003904 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 471852003905 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 471852003906 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471852003907 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852003908 DNA binding residues [nucleotide binding] 471852003909 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471852003910 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 471852003911 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 471852003912 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 471852003913 Cytochrome P450; Region: p450; cl12078 471852003914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852003915 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 471852003916 DinB superfamily; Region: DinB_2; cl00986 471852003917 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 471852003918 active site 471852003919 amidase; Provisional; Region: PRK07869 471852003920 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 471852003921 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 471852003922 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852003923 active site 471852003924 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 471852003925 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 471852003926 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 471852003927 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 471852003928 putative active site [active] 471852003929 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_C; cd03414 471852003930 putative active site [active] 471852003931 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 471852003932 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 471852003933 Active Sites [active] 471852003934 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; cl07038 471852003935 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 471852003936 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471852003937 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471852003938 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 471852003939 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 471852003940 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 471852003941 active site 471852003942 MMPL family; Region: MMPL; pfam03176 471852003943 MMPL family; Region: MMPL; pfam03176 471852003944 Transport protein; Region: actII; TIGR00833 471852003945 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471852003946 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471852003947 Transcription factor WhiB; Region: Whib; pfam02467 471852003948 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 471852003949 putative [2Fe-2S] cluster binding site [ion binding]; other site 471852003950 putative dimer interface [polypeptide binding]; other site 471852003951 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 471852003952 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 471852003953 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852003954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852003955 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471852003956 FAD binding domain; Region: FAD_binding_4; pfam01565 471852003957 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471852003958 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471852003959 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471852003960 active site 471852003961 metal binding site [ion binding]; metal-binding site 471852003962 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471852003963 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 471852003964 Walker A/P-loop; other site 471852003965 ATP binding site [chemical binding]; other site 471852003966 Q-loop/lid; other site 471852003967 ABC transporter signature motif; other site 471852003968 Walker B; other site 471852003969 D-loop; other site 471852003970 H-loop/switch region; other site 471852003971 Nitrate and nitrite sensing; Region: NIT; pfam08376 471852003972 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852003973 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471852003974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852003975 ATP binding site [chemical binding]; other site 471852003976 Mg2+ binding site [ion binding]; other site 471852003977 G-X-G motif; other site 471852003978 Protein of unknown function (DUF3729); Region: DUF3729; pfam12526 471852003979 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 471852003980 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471852003981 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852003982 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471852003983 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 471852003984 Walker A/P-loop; other site 471852003985 ATP binding site [chemical binding]; other site 471852003986 Q-loop/lid; other site 471852003987 ABC transporter signature motif; other site 471852003988 Walker B; other site 471852003989 D-loop; other site 471852003990 H-loop/switch region; other site 471852003991 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471852003992 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 471852003993 catalytic residues [active] 471852003994 dimer interface [polypeptide binding]; other site 471852003995 short chain dehydrogenase; Provisional; Region: PRK06197 471852003996 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 471852003997 putative NAD(P) binding site [chemical binding]; other site 471852003998 active site 471852003999 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 471852004000 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 471852004001 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 471852004002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852004003 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 471852004004 Walker A motif; other site 471852004005 ATP binding site [chemical binding]; other site 471852004006 Walker B motif; other site 471852004007 arginine finger; other site 471852004008 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 471852004009 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 471852004010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852004011 NAD(P) binding site [chemical binding]; other site 471852004012 active site 471852004013 Domain of unknown function (DUF385); Region: DUF385; cl04387 471852004014 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852004015 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852004016 DNA binding residues [nucleotide binding] 471852004017 dimerization interface [polypeptide binding]; other site 471852004018 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 471852004019 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 471852004020 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471852004021 NAD binding site [chemical binding]; other site 471852004022 catalytic residues [active] 471852004023 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 471852004024 catalytic motif [active] 471852004025 Zn binding site [ion binding]; other site 471852004026 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 471852004027 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 471852004028 ligand binding site [chemical binding]; other site 471852004029 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 471852004030 ligand binding site [chemical binding]; other site 471852004031 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 471852004032 oligomerisation interface [polypeptide binding]; other site 471852004033 mobile loop; other site 471852004034 roof hairpin; other site 471852004035 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 471852004036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852004037 NAD(P) binding site [chemical binding]; other site 471852004038 active site 471852004039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852004040 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 471852004041 putative lipid kinase; Reviewed; Region: PRK13057 471852004042 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471852004043 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 471852004044 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852004045 Predicted esterase [General function prediction only]; Region: COG0627 471852004046 Cation efflux family; Region: Cation_efflux; cl00316 471852004047 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 471852004048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852004049 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: VWA_YIEM_type; cd01462 471852004050 metal ion-dependent adhesion site (MIDAS); other site 471852004051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852004052 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 471852004053 Walker A motif; other site 471852004054 ATP binding site [chemical binding]; other site 471852004055 Walker B motif; other site 471852004056 arginine finger; other site 471852004057 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852004058 active site 471852004059 ATP binding site [chemical binding]; other site 471852004060 substrate binding site [chemical binding]; other site 471852004061 activation loop (A-loop); other site 471852004062 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 471852004063 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 471852004064 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 471852004065 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471852004066 metal ion-dependent adhesion site (MIDAS); other site 471852004067 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 471852004068 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 471852004069 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 471852004070 ATP binding site [chemical binding]; other site 471852004071 Walker A motif; other site 471852004072 hexamer interface [polypeptide binding]; other site 471852004073 Walker B motif; other site 471852004074 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471852004075 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 471852004076 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852004077 SAF domain; Region: SAF; cl00555 471852004078 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852004079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852004080 DNA binding residues [nucleotide binding] 471852004081 dimerization interface [polypeptide binding]; other site 471852004082 CoA-transferase family III; Region: CoA_transf_3; cl00778 471852004083 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 471852004084 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471852004085 dimer interface [polypeptide binding]; other site 471852004086 active site 471852004087 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 471852004088 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 471852004089 carboxyltransferase (CT) interaction site; other site 471852004090 biotinylation site [posttranslational modification]; other site 471852004091 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 471852004092 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471852004093 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471852004094 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471852004095 metal ion-dependent adhesion site (MIDAS); other site 471852004096 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 471852004097 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 471852004098 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 471852004099 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active...; Region: PTE; cd00530 471852004100 active site 471852004101 substrate binding pocket [chemical binding]; other site 471852004102 homodimer interaction site [polypeptide binding]; other site 471852004103 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 471852004104 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852004105 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 471852004106 putative FMN binding site [chemical binding]; other site 471852004107 Hsp70 protein; Region: HSP70; pfam00012 471852004108 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cl03075 471852004109 dimer interface [polypeptide binding]; other site 471852004110 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 471852004111 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 471852004112 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 471852004113 intersubunit interface [polypeptide binding]; other site 471852004114 active site 471852004115 Zn2+ binding site [ion binding]; other site 471852004116 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 471852004117 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852004118 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471852004119 active site 471852004120 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 471852004121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852004122 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 471852004123 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 471852004124 dimer interface [polypeptide binding]; other site 471852004125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852004126 catalytic residue [active] 471852004127 peptide synthase; Provisional; Region: PRK12467 471852004128 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852004129 Condensation domain; Region: Condensation; cl09290 471852004130 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471852004131 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852004132 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852004133 Condensation domain; Region: Condensation; cl09290 471852004134 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 471852004135 Condensation domain; Region: Condensation; cl09290 471852004136 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 471852004137 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852004138 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852004139 Condensation domain; Region: Condensation; cl09290 471852004140 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471852004141 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852004142 Condensation domain; Region: Condensation; cl09290 471852004143 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 471852004144 Condensation domain; Region: Condensation; cl09290 471852004145 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471852004146 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852004147 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852004148 Condensation domain; Region: Condensation; cl09290 471852004149 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471852004150 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852004151 Condensation domain; Region: Condensation; cl09290 471852004152 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 471852004153 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 471852004154 Condensation domain; Region: Condensation; cl09290 471852004155 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852004156 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852004157 MbtH-like protein; Region: MbtH; cl01279 471852004158 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 471852004159 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852004160 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471852004161 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 471852004162 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 471852004163 catalytic triad [active] 471852004164 Predicted acyl esterases [General function prediction only]; Region: COG2936 471852004165 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 471852004166 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471852004167 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 471852004168 active site 471852004169 substrate binding site [chemical binding]; other site 471852004170 catalytic site [active] 471852004171 tetracycline repressor protein TetR; Provisional; Region: PRK13756 471852004172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852004173 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471852004174 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 471852004175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 471852004176 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 471852004177 TIGR03442 family protein; Region: TIGR03442 471852004178 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 471852004179 putative active site [active] 471852004180 putative dimer interface [polypeptide binding]; other site 471852004181 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471852004182 Uncharacterized conserved protein [Function unknown]; Region: COG4997 471852004183 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 471852004184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852004185 Beta-Casp domain; Region: Beta-Casp; cl12567 471852004186 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 471852004187 envelope glycoprotein C; Provisional; Region: PHA03269 471852004188 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471852004189 HerA helicase [Replication, recombination, and repair]; Region: COG0433 471852004190 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 471852004191 active site 471852004192 metal binding site [ion binding]; metal-binding site 471852004193 DNA binding site [nucleotide binding] 471852004194 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852004195 Walker A/P-loop; other site 471852004196 ATP binding site [chemical binding]; other site 471852004197 Q-loop/lid; other site 471852004198 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852004199 ABC transporter signature motif; other site 471852004200 Walker B; other site 471852004201 D-loop; other site 471852004202 H-loop/switch region; other site 471852004203 NurA domain; Region: NurA; cl09134 471852004204 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471852004205 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471852004206 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852004207 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852004208 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852004209 active site 471852004210 ATP binding site [chemical binding]; other site 471852004211 substrate binding site [chemical binding]; other site 471852004212 activation loop (A-loop); other site 471852004213 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852004214 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852004215 active site 471852004216 ATP binding site [chemical binding]; other site 471852004217 substrate binding site [chemical binding]; other site 471852004218 activation loop (A-loop); other site 471852004219 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 471852004220 structural tetrad; other site 471852004221 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471852004222 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 471852004223 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 471852004224 CGNR zinc finger; Region: zf-CGNR; pfam11706 471852004225 Protein of unknown function DUF72; Region: DUF72; cl00777 471852004226 Protein of unknown function (DUF419); Region: DUF419; cl15265 471852004227 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 471852004228 hypothetical protein; Provisional; Region: PRK11770 471852004229 Domain of unknown function (DUF307); Region: DUF307; pfam03733 471852004230 Domain of unknown function (DUF307); Region: DUF307; pfam03733 471852004231 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 471852004232 putative dimer interface [polypeptide binding]; other site 471852004233 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 471852004234 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 471852004235 dimer interface [polypeptide binding]; other site 471852004236 active site 471852004237 heme binding site [chemical binding]; other site 471852004238 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 471852004239 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471852004240 metal binding site 2 [ion binding]; metal-binding site 471852004241 putative DNA binding helix; other site 471852004242 metal binding site 1 [ion binding]; metal-binding site 471852004243 dimer interface [polypeptide binding]; other site 471852004244 structural Zn2+ binding site [ion binding]; other site 471852004245 Protein of unknown function DUF262; Region: DUF262; cl14890 471852004246 Uncharacterized conserved protein (DUF2081); Region: DUF2081; cl09179 471852004247 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852004248 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852004249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852004250 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471852004251 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852004252 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852004253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852004254 S-adenosylmethionine binding site [chemical binding]; other site 471852004255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852004256 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471852004257 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 471852004258 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 471852004259 beta-alpha-beta structure motif; other site 471852004260 NAD binding pocket [chemical binding]; other site 471852004261 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 471852004262 Di-iron ligands [ion binding]; other site 471852004263 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 471852004264 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 471852004265 D-pathway; other site 471852004266 Putative ubiquinol binding site [chemical binding]; other site 471852004267 Low-spin heme (heme b) binding site [chemical binding]; other site 471852004268 Putative water exit pathway; other site 471852004269 Binuclear center (heme o3/CuB) [ion binding]; other site 471852004270 K-pathway; other site 471852004271 Putative proton exit pathway; other site 471852004272 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471852004273 OsmC-like protein; Region: OsmC; cl00767 471852004274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852004275 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 471852004276 dimer interface [polypeptide binding]; other site 471852004277 Citrate synthase; Region: Citrate_synt; pfam00285 471852004278 active site 471852004279 citrylCoA binding site [chemical binding]; other site 471852004280 NADH binding [chemical binding]; other site 471852004281 cationic pore residues; other site 471852004282 oxalacetate/citrate binding site [chemical binding]; other site 471852004283 coenzyme A binding site [chemical binding]; other site 471852004284 catalytic triad [active] 471852004285 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852004286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852004287 FAD binding domain; Region: FAD_binding_4; pfam01565 471852004288 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 471852004289 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 471852004290 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 471852004291 active site 471852004292 homotetramer interface [polypeptide binding]; other site 471852004293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852004294 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852004295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471852004296 non-specific DNA binding site [nucleotide binding]; other site 471852004297 salt bridge; other site 471852004298 sequence-specific DNA binding site [nucleotide binding]; other site 471852004299 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 471852004300 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471852004301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852004302 putative substrate translocation pore; other site 471852004303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852004304 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852004305 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852004306 active site 471852004307 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 471852004308 active site 471852004309 catalytic residues [active] 471852004310 metal binding site [ion binding]; metal-binding site 471852004311 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 471852004312 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471852004313 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471852004314 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 471852004315 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 471852004316 carboxyltransferase (CT) interaction site; other site 471852004317 biotinylation site [posttranslational modification]; other site 471852004318 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 471852004319 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471852004320 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852004321 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 471852004322 tetramer interface [polypeptide binding]; other site 471852004323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852004324 catalytic residue [active] 471852004325 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 471852004326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852004327 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471852004328 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471852004329 catalytic core [active] 471852004330 Nuclease-related domain; Region: NERD; pfam08378 471852004331 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 471852004332 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852004333 ATP binding site [chemical binding]; other site 471852004334 putative Mg++ binding site [ion binding]; other site 471852004335 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852004336 Helicase associated domain (HA2); Region: HA2; cl04503 471852004337 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 471852004338 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471852004339 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 471852004340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852004341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852004342 DNA binding residues [nucleotide binding] 471852004343 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471852004344 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471852004345 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471852004346 Predicted ATPase [General function prediction only]; Region: COG3899 471852004347 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 471852004348 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852004349 dimerization interface [polypeptide binding]; other site 471852004350 DNA binding residues [nucleotide binding] 471852004351 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 471852004352 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 471852004353 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 471852004354 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471852004355 Cysteine-rich domain; Region: CCG; pfam02754 471852004356 Cysteine-rich domain; Region: CCG; pfam02754 471852004357 alpha-glucosidase; Provisional; Region: PRK10137 471852004358 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 471852004359 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 471852004360 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471852004361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852004362 DNA-binding site [nucleotide binding]; DNA binding site 471852004363 UTRA domain; Region: UTRA; cl01230 471852004364 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 471852004365 dimer interface [polypeptide binding]; other site 471852004366 ADP-ribose binding site [chemical binding]; other site 471852004367 active site 471852004368 nudix motif; other site 471852004369 metal binding site [ion binding]; metal-binding site 471852004370 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471852004371 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471852004372 catalytic core [active] 471852004373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852004374 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852004375 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471852004376 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 471852004377 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 471852004378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852004379 NAD(P) binding site [chemical binding]; other site 471852004380 active site 471852004381 exopolyphosphatase; Region: exo_poly_only; TIGR03706 471852004382 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 471852004383 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852004384 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852004385 active site 471852004386 ATP binding site [chemical binding]; other site 471852004387 substrate binding site [chemical binding]; other site 471852004388 activation loop (A-loop); other site 471852004389 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 471852004390 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471852004391 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471852004392 FeS/SAM binding site; other site 471852004393 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 471852004394 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 471852004395 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 471852004396 active site 471852004397 ChaB; Region: ChaB; cl01887 471852004398 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 471852004399 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471852004400 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 471852004401 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471852004402 putative NAD(P) binding site [chemical binding]; other site 471852004403 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 471852004404 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 471852004405 putative NAD(P) binding site [chemical binding]; other site 471852004406 putative substrate binding site [chemical binding]; other site 471852004407 catalytic Zn binding site [ion binding]; other site 471852004408 structural Zn binding site [ion binding]; other site 471852004409 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471852004410 metal ion-dependent adhesion site (MIDAS); other site 471852004411 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471852004412 Ligand Binding Site [chemical binding]; other site 471852004413 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 471852004414 hypothetical protein; Reviewed; Region: PRK09588 471852004415 Archease protein family (DUF101/UPF0211); Region: Archease; cl00606 471852004416 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 471852004417 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852004418 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 471852004419 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852004420 substrate binding pocket [chemical binding]; other site 471852004421 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 471852004422 putative hydrophobic ligand binding site [chemical binding]; other site 471852004423 Peptidase family M48; Region: Peptidase_M48; cl12018 471852004424 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471852004425 active site residue [active] 471852004426 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852004427 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471852004428 active site residue [active] 471852004429 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471852004430 active site residue [active] 471852004431 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 471852004432 putative homotetramer interface [polypeptide binding]; other site 471852004433 putative homodimer interface [polypeptide binding]; other site 471852004434 putative allosteric switch controlling residues; other site 471852004435 putative metal binding site [ion binding]; other site 471852004436 putative homodimer-homodimer interface [polypeptide binding]; other site 471852004437 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 471852004438 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 471852004439 BON domain; Region: BON; cl02771 471852004440 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471852004441 Ligand Binding Site [chemical binding]; other site 471852004442 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471852004443 Ligand Binding Site [chemical binding]; other site 471852004444 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471852004445 Ligand Binding Site [chemical binding]; other site 471852004446 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 471852004447 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471852004448 anti sigma factor interaction site; other site 471852004449 regulatory phosphorylation site [posttranslational modification]; other site 471852004450 chorismate binding enzyme; Region: Chorismate_bind; cl10555 471852004451 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 471852004452 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 471852004453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852004454 Aminotransferase class IV; Region: Aminotran_4; pfam01063 471852004455 catalytic residue [active] 471852004456 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 471852004457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852004458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852004459 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471852004460 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 471852004461 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 471852004462 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 471852004463 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471852004464 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 471852004465 classical (c) SDRs; Region: SDR_c; cd05233 471852004466 NAD(P) binding site [chemical binding]; other site 471852004467 active site 471852004468 Copper resistance protein CopC; Region: CopC; cl01012 471852004469 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 471852004470 Uncharacterized conserved protein [Function unknown]; Region: COG1306 471852004471 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 471852004472 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 471852004473 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 471852004474 CrcB-like protein; Region: CRCB; cl09114 471852004475 CrcB-like protein; Region: CRCB; cl09114 471852004476 UreD urease accessory protein; Region: UreD; cl00530 471852004477 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852004478 UreF; Region: UreF; pfam01730 471852004479 urease subunit alpha; Reviewed; Region: ureC; PRK13207 471852004480 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 471852004481 subunit interactions [polypeptide binding]; other site 471852004482 active site 471852004483 flap region; other site 471852004484 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 471852004485 alpha-beta subunit interface [polypeptide binding]; other site 471852004486 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and...; Region: Chelatase_Class_II; cl02784 471852004487 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 471852004488 alpha-gamma subunit interface [polypeptide binding]; other site 471852004489 beta-gamma subunit interface [polypeptide binding]; other site 471852004490 Urea transporter; Region: UT; cl01829 471852004491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852004492 Flavoprotein; Region: Flavoprotein; cl08021 471852004493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471852004494 non-specific DNA binding site [nucleotide binding]; other site 471852004495 salt bridge; other site 471852004496 sequence-specific DNA binding site [nucleotide binding]; other site 471852004497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852004498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852004499 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 471852004500 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471852004501 dimer interface [polypeptide binding]; other site 471852004502 active site 471852004503 CoA binding pocket [chemical binding]; other site 471852004504 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471852004505 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471852004506 active site 471852004507 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 471852004508 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852004509 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 471852004510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852004511 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852004512 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852004513 active site 471852004514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852004515 short chain dehydrogenase; Provisional; Region: PRK12828 471852004516 NAD(P) binding site [chemical binding]; other site 471852004517 active site 471852004518 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471852004519 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 471852004520 NAD(P) binding site [chemical binding]; other site 471852004521 phosphate acetyltransferase; Reviewed; Region: PRK05632 471852004522 DRTGG domain; Region: DRTGG; cl12147 471852004523 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 471852004524 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 471852004525 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 471852004526 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 471852004527 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 471852004528 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 471852004529 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 471852004530 active site 471852004531 dimer interface [polypeptide binding]; other site 471852004532 motif 1; other site 471852004533 motif 2; other site 471852004534 motif 3; other site 471852004535 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 471852004536 anticodon binding site; other site 471852004537 Protein of unknown function (DUF322); Region: DUF322; cl00574 471852004538 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 471852004539 nucleotide binding site/active site [active] 471852004540 HIT family signature motif; other site 471852004541 catalytic residue [active] 471852004542 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170 471852004543 elongation factor G; Reviewed; Region: PRK12740 471852004544 G1 box; other site 471852004545 putative GEF interaction site [polypeptide binding]; other site 471852004546 GTP/Mg2+ binding site [chemical binding]; other site 471852004547 Switch I region; other site 471852004548 G2 box; other site 471852004549 G3 box; other site 471852004550 Switch II region; other site 471852004551 G4 box; other site 471852004552 G5 box; other site 471852004553 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 471852004554 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 471852004555 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 471852004556 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471852004557 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 471852004558 putative acyl-acceptor binding pocket; other site 471852004559 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471852004560 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471852004561 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 471852004562 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 471852004563 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 471852004564 active site 471852004565 multimer interface [polypeptide binding]; other site 471852004566 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 471852004567 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 471852004568 predicted active site [active] 471852004569 catalytic triad [active] 471852004570 Domain of unknown function DUF28; Region: DUF28; cl00361 471852004571 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 471852004572 active site 471852004573 putative DNA-binding cleft [nucleotide binding]; other site 471852004574 dimer interface [polypeptide binding]; other site 471852004575 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 471852004576 RuvA N terminal domain; Region: RuvA_N; pfam01330 471852004577 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 471852004578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852004579 Walker A motif; other site 471852004580 ATP binding site [chemical binding]; other site 471852004581 Walker B motif; other site 471852004582 arginine finger; other site 471852004583 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 471852004584 Preprotein translocase subunit; Region: YajC; cl00806 471852004585 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 471852004586 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 471852004587 Protein export membrane protein; Region: SecD_SecF; cl14618 471852004588 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 471852004589 Protein export membrane protein; Region: SecD_SecF; cl14618 471852004590 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471852004591 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 471852004592 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471852004593 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471852004594 synthetase active site [active] 471852004595 NTP binding site [chemical binding]; other site 471852004596 metal binding site [ion binding]; metal-binding site 471852004597 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 471852004598 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 471852004599 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471852004600 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471852004601 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 471852004602 active site 471852004603 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852004604 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 471852004605 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 471852004606 dimer interface [polypeptide binding]; other site 471852004607 motif 1; other site 471852004608 active site 471852004609 motif 2; other site 471852004610 motif 3; other site 471852004611 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 471852004612 anticodon binding site; other site 471852004613 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 471852004614 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 471852004615 ATP binding site [chemical binding]; other site 471852004616 substrate interface [chemical binding]; other site 471852004617 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 471852004618 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 471852004619 Dimer interface [polypeptide binding]; other site 471852004620 anticodon binding site; other site 471852004621 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471852004622 motif 1; other site 471852004623 dimer interface [polypeptide binding]; other site 471852004624 active site 471852004625 motif 2; other site 471852004626 motif 3; other site 471852004627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471852004628 non-specific DNA binding site [nucleotide binding]; other site 471852004629 salt bridge; other site 471852004630 sequence-specific DNA binding site [nucleotide binding]; other site 471852004631 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852004632 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 471852004633 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 471852004634 dimer interface [polypeptide binding]; other site 471852004635 anticodon binding site; other site 471852004636 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 471852004637 homodimer interface [polypeptide binding]; other site 471852004638 motif 1; other site 471852004639 active site 471852004640 motif 2; other site 471852004641 GAD domain; Region: GAD; pfam02938 471852004642 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 471852004643 motif 3; other site 471852004644 Domain of unknown function (DUF305); Region: DUF305; pfam03713 471852004645 Domain of unknown function (DUF305); Region: DUF305; pfam03713 471852004646 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 471852004647 recombination factor protein RarA; Reviewed; Region: PRK13342 471852004648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852004649 Walker A motif; other site 471852004650 ATP binding site [chemical binding]; other site 471852004651 Walker B motif; other site 471852004652 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 471852004653 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 471852004654 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 471852004655 motif 1; other site 471852004656 active site 471852004657 motif 2; other site 471852004658 motif 3; other site 471852004659 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 471852004660 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 471852004661 YceG-like family; Region: YceG; pfam02618 471852004662 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 471852004663 dimerization interface [polypeptide binding]; other site 471852004664 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 471852004665 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 471852004666 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 471852004667 shikimate binding site; other site 471852004668 NAD(P) binding site [chemical binding]; other site 471852004669 translation initiation factor IF-3; Region: infC; TIGR00168 471852004670 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 471852004671 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 471852004672 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 471852004673 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 471852004674 23S rRNA binding site [nucleotide binding]; other site 471852004675 L21 binding site [polypeptide binding]; other site 471852004676 L13 binding site [polypeptide binding]; other site 471852004677 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471852004678 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 471852004679 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471852004680 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471852004681 anti sigma factor interaction site; other site 471852004682 regulatory phosphorylation site [posttranslational modification]; other site 471852004683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471852004684 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471852004685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471852004686 dimer interface [polypeptide binding]; other site 471852004687 phosphorylation site [posttranslational modification] 471852004688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852004689 ATP binding site [chemical binding]; other site 471852004690 Mg2+ binding site [ion binding]; other site 471852004691 G-X-G motif; other site 471852004692 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 471852004693 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 471852004694 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 471852004695 dimer interface [polypeptide binding]; other site 471852004696 motif 1; other site 471852004697 active site 471852004698 motif 2; other site 471852004699 motif 3; other site 471852004700 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 471852004701 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 471852004702 putative tRNA-binding site [nucleotide binding]; other site 471852004703 B3/4 domain; Region: B3_4; cl11458 471852004704 tRNA synthetase B5 domain; Region: B5; cl08394 471852004705 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 471852004706 dimer interface [polypeptide binding]; other site 471852004707 motif 1; other site 471852004708 motif 3; other site 471852004709 motif 2; other site 471852004710 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 471852004711 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852004712 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471852004713 Walker A/P-loop; other site 471852004714 ATP binding site [chemical binding]; other site 471852004715 Q-loop/lid; other site 471852004716 ABC transporter signature motif; other site 471852004717 Walker B; other site 471852004718 D-loop; other site 471852004719 H-loop/switch region; other site 471852004720 ABC transporter; Region: ABC_tran_2; pfam12848 471852004721 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 471852004722 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471852004723 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 471852004724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852004725 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 471852004726 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 471852004727 heterotetramer interface [polypeptide binding]; other site 471852004728 active site pocket [active] 471852004729 cleavage site 471852004730 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 471852004731 feedback inhibition sensing region; other site 471852004732 homohexameric interface [polypeptide binding]; other site 471852004733 nucleotide binding site [chemical binding]; other site 471852004734 N-acetyl-L-glutamate binding site [chemical binding]; other site 471852004735 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 471852004736 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 471852004737 inhibitor-cofactor binding pocket; inhibition site 471852004738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852004739 catalytic residue [active] 471852004740 ornithine carbamoyltransferase; Provisional; Region: PRK00779 471852004741 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471852004742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852004743 arginine repressor; Provisional; Region: PRK03341 471852004744 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 471852004745 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 471852004746 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 471852004747 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 471852004748 ANP binding site [chemical binding]; other site 471852004749 Substrate Binding Site II [chemical binding]; other site 471852004750 Substrate Binding Site I [chemical binding]; other site 471852004751 argininosuccinate lyase; Provisional; Region: PRK00855 471852004752 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 471852004753 active sites [active] 471852004754 tetramer interface [polypeptide binding]; other site 471852004755 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 471852004756 active site 471852004757 DNA binding site [nucleotide binding] 471852004758 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 471852004759 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 471852004760 active site 471852004761 HIGH motif; other site 471852004762 dimer interface [polypeptide binding]; other site 471852004763 KMSKS motif; other site 471852004764 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 471852004765 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 471852004766 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471852004767 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852004768 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 471852004769 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 471852004770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471852004771 active site 471852004772 motif I; other site 471852004773 motif II; other site 471852004774 SCP-2 sterol transfer family; Region: SCP2; cl01225 471852004775 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 471852004776 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471852004777 RNA binding surface [nucleotide binding]; other site 471852004778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852004779 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471852004780 ATP-NAD kinase; Region: NAD_kinase; pfam01513 471852004781 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 471852004782 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 471852004783 Walker A/P-loop; other site 471852004784 ATP binding site [chemical binding]; other site 471852004785 Q-loop/lid; other site 471852004786 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 471852004787 ABC transporter signature motif; other site 471852004788 Walker B; other site 471852004789 D-loop; other site 471852004790 H-loop/switch region; other site 471852004791 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 471852004792 Thiamine pyrophosphokinase; Region: TPK; cl09135 471852004793 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 471852004794 integral membrane protein MviN; Region: mviN; TIGR01695 471852004795 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471852004796 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852004797 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471852004798 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852004799 active site 471852004800 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852004801 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852004802 active site 471852004803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852004804 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 471852004805 Walker A motif; other site 471852004806 ATP binding site [chemical binding]; other site 471852004807 Walker B motif; other site 471852004808 arginine finger; other site 471852004809 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 471852004810 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471852004811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852004812 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852004813 cyclase homology domain; Region: CHD; cd07302 471852004814 nucleotidyl binding site; other site 471852004815 metal binding site [ion binding]; metal-binding site 471852004816 dimer interface [polypeptide binding]; other site 471852004817 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 471852004818 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 471852004819 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 471852004820 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 471852004821 molybdopterin cofactor binding site; other site 471852004822 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929 471852004823 molybdopterin cofactor binding site; other site 471852004824 Predicted kinase [General function prediction only]; Region: COG0645 471852004825 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852004826 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 471852004827 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 471852004828 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 471852004829 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 471852004830 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 471852004831 iron-sulfur cluster [ion binding]; other site 471852004832 [2Fe-2S] cluster binding site [ion binding]; other site 471852004833 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 471852004834 iron-sulfur cluster [ion binding]; other site 471852004835 [2Fe-2S] cluster binding site [ion binding]; other site 471852004836 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 471852004837 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471852004838 GIY-YIG motif/motif A; other site 471852004839 active site 471852004840 catalytic site [active] 471852004841 putative DNA binding site [nucleotide binding]; other site 471852004842 metal binding site [ion binding]; metal-binding site 471852004843 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 471852004844 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471852004845 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852004846 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 471852004847 phosphate binding site [ion binding]; other site 471852004848 putative substrate binding pocket [chemical binding]; other site 471852004849 dimer interface [polypeptide binding]; other site 471852004850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 471852004851 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 471852004852 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 471852004853 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 471852004854 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 471852004855 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 471852004856 substrate binding site [chemical binding]; other site 471852004857 hinge regions; other site 471852004858 ADP binding site [chemical binding]; other site 471852004859 catalytic site [active] 471852004860 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471852004861 substrate binding site [chemical binding]; other site 471852004862 dimer interface [polypeptide binding]; other site 471852004863 catalytic triad [active] 471852004864 Preprotein translocase SecG subunit; Region: SecG; cl09123 471852004865 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471852004866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471852004867 putative DNA binding site [nucleotide binding]; other site 471852004868 dimerization interface [polypeptide binding]; other site 471852004869 putative Zn2+ binding site [ion binding]; other site 471852004870 Peptidase family M23; Region: Peptidase_M23; pfam01551 471852004871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852004872 S-adenosylmethionine binding site [chemical binding]; other site 471852004873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852004874 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 471852004875 putative active site [active] 471852004876 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 471852004877 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 471852004878 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 471852004879 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 471852004880 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 471852004881 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 471852004882 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 471852004883 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 471852004884 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 471852004885 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 471852004886 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 471852004887 putative active site [active] 471852004888 transaldolase; Provisional; Region: PRK03903 471852004889 catalytic residue [active] 471852004890 transketolase; Reviewed; Region: PRK05899 471852004891 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471852004892 TPP-binding site [chemical binding]; other site 471852004893 dimer interface [polypeptide binding]; other site 471852004894 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471852004895 PYR/PP interface [polypeptide binding]; other site 471852004896 dimer interface [polypeptide binding]; other site 471852004897 TPP binding site [chemical binding]; other site 471852004898 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471852004899 UbiA prenyltransferase family; Region: UbiA; cl00337 471852004900 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 471852004901 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 471852004902 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 471852004903 threonine and homoserine efflux system; Provisional; Region: PRK10532 471852004904 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471852004905 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471852004906 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471852004907 Walker A/P-loop; other site 471852004908 ATP binding site [chemical binding]; other site 471852004909 Q-loop/lid; other site 471852004910 ABC transporter signature motif; other site 471852004911 Walker B; other site 471852004912 D-loop; other site 471852004913 H-loop/switch region; other site 471852004914 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 471852004915 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 471852004916 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471852004917 Ligand Binding Site [chemical binding]; other site 471852004918 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 471852004919 Predicted transcriptional regulator [Transcription]; Region: COG2345 471852004920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852004921 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 471852004922 FeS assembly protein SufB; Region: sufB; TIGR01980 471852004923 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 471852004924 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 471852004925 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 471852004926 [2Fe-2S] cluster binding site [ion binding]; other site 471852004927 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 471852004928 FeS assembly ATPase SufC; Region: sufC; TIGR01978 471852004929 Walker A/P-loop; other site 471852004930 ATP binding site [chemical binding]; other site 471852004931 Q-loop/lid; other site 471852004932 ABC transporter signature motif; other site 471852004933 Walker B; other site 471852004934 D-loop; other site 471852004935 H-loop/switch region; other site 471852004936 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471852004937 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 471852004938 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471852004939 catalytic residue [active] 471852004940 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 471852004941 trimerization site [polypeptide binding]; other site 471852004942 active site 471852004943 Domain of unknown function DUF59; Region: DUF59; cl00941 471852004944 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471852004945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852004946 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852004947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852004948 active site 471852004949 phosphorylation site [posttranslational modification] 471852004950 intermolecular recognition site; other site 471852004951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852004952 DNA binding residues [nucleotide binding] 471852004953 dimerization interface [polypeptide binding]; other site 471852004954 Protein of unknown function DUF124; Region: DUF124; cl00884 471852004955 Protein of unknown function DUF124; Region: DUF124; cl00884 471852004956 Protein of unknown function DUF124; Region: DUF124; cl00884 471852004957 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471852004958 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852004959 Walker A/P-loop; other site 471852004960 ATP binding site [chemical binding]; other site 471852004961 Q-loop/lid; other site 471852004962 ABC transporter signature motif; other site 471852004963 Walker B; other site 471852004964 D-loop; other site 471852004965 H-loop/switch region; other site 471852004966 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 471852004967 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852004968 substrate binding site [chemical binding]; other site 471852004969 oxyanion hole (OAH) forming residues; other site 471852004970 trimer interface [polypeptide binding]; other site 471852004971 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 471852004972 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471852004973 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852004974 Walker A/P-loop; other site 471852004975 ATP binding site [chemical binding]; other site 471852004976 Q-loop/lid; other site 471852004977 ABC transporter signature motif; other site 471852004978 Walker B; other site 471852004979 D-loop; other site 471852004980 H-loop/switch region; other site 471852004981 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 471852004982 NAD-dependent deacetylase; Provisional; Region: PRK05333 471852004983 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 471852004984 FOG: CBS domain [General function prediction only]; Region: COG0517 471852004985 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_10; cd04623 471852004986 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852004987 DNA-binding site [nucleotide binding]; DNA binding site 471852004988 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471852004989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852004990 homodimer interface [polypeptide binding]; other site 471852004991 catalytic residue [active] 471852004992 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471852004993 short chain dehydrogenase; Validated; Region: PRK05855 471852004994 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852004995 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 471852004996 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 471852004997 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471852004998 Ligand Binding Site [chemical binding]; other site 471852004999 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 471852005000 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471852005001 NAD binding site [chemical binding]; other site 471852005002 catalytic Zn binding site [ion binding]; other site 471852005003 structural Zn binding site [ion binding]; other site 471852005004 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051 471852005005 Ca2+ binding site [ion binding]; other site 471852005006 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471852005007 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471852005008 ligand binding site [chemical binding]; other site 471852005009 flexible hinge region; other site 471852005010 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852005011 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 471852005012 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852005013 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852005014 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 471852005015 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 471852005016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852005017 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471852005018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852005019 SelB subfamily. SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of...; Region: SelB; cd04171 471852005020 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 471852005021 G1 box; other site 471852005022 putative GEF interaction site [polypeptide binding]; other site 471852005023 GTP/Mg2+ binding site [chemical binding]; other site 471852005024 Switch I region; other site 471852005025 G2 box; other site 471852005026 G3 box; other site 471852005027 Switch II region; other site 471852005028 G4 box; other site 471852005029 G5 box; other site 471852005030 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires...; Region: selB_II; cd03696 471852005031 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-...; Region: Translation_factor_III; cl02786 471852005032 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 471852005033 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 471852005034 hypothetical protein; Reviewed; Region: PRK09588 471852005035 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 471852005036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471852005037 FeS/SAM binding site; other site 471852005038 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 471852005039 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471852005040 active site 471852005041 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 471852005042 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 471852005043 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471852005044 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 471852005045 Protein of unknown function (DUF1458); Region: DUF1458; cl01328 471852005046 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 471852005047 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 471852005048 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 471852005049 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 471852005050 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 471852005051 NAD(P) binding site [chemical binding]; other site 471852005052 homotetramer interface [polypeptide binding]; other site 471852005053 homodimer interface [polypeptide binding]; other site 471852005054 active site 471852005055 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 471852005056 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 471852005057 NAD binding site [chemical binding]; other site 471852005058 homotetramer interface [polypeptide binding]; other site 471852005059 homodimer interface [polypeptide binding]; other site 471852005060 substrate binding site [chemical binding]; other site 471852005061 active site 471852005062 RecD/TraA family; Region: recD_rel; TIGR01448 471852005063 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471852005064 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 471852005065 active site 471852005066 catalytic tetrad [active] 471852005067 Bacitracin resistance protein BacA; Region: BacA; cl00858 471852005068 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471852005069 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471852005070 catalytic core [active] 471852005071 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 471852005072 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (...; Region: PI3Kc_like; cl00119 471852005073 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 471852005074 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471852005075 active site 471852005076 HIGH motif; other site 471852005077 nucleotide binding site [chemical binding]; other site 471852005078 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471852005079 active site 471852005080 KMSKS motif; other site 471852005081 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471852005082 tRNA binding surface [nucleotide binding]; other site 471852005083 anticodon binding site; other site 471852005084 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471852005085 PAC2 family; Region: PAC2; cl00847 471852005086 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471852005087 Ligand Binding Site [chemical binding]; other site 471852005088 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 471852005089 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 471852005090 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 471852005091 substrate binding pocket [chemical binding]; other site 471852005092 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 471852005093 B12 binding site [chemical binding]; other site 471852005094 cobalt ligand [ion binding]; other site 471852005095 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 471852005096 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 471852005097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471852005098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471852005099 motif II; other site 471852005100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852005101 dimer interface [polypeptide binding]; other site 471852005102 conserved gate region; other site 471852005103 putative PBP binding loops; other site 471852005104 ABC-ATPase subunit interface; other site 471852005105 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 471852005106 peptide binding site [polypeptide binding]; other site 471852005107 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471852005108 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471852005109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852005110 dimer interface [polypeptide binding]; other site 471852005111 conserved gate region; other site 471852005112 ABC-ATPase subunit interface; other site 471852005113 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471852005114 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471852005115 Walker A/P-loop; other site 471852005116 ATP binding site [chemical binding]; other site 471852005117 Q-loop/lid; other site 471852005118 ABC transporter signature motif; other site 471852005119 Walker B; other site 471852005120 D-loop; other site 471852005121 H-loop/switch region; other site 471852005122 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471852005123 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 471852005124 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471852005125 Walker A/P-loop; other site 471852005126 ATP binding site [chemical binding]; other site 471852005127 Q-loop/lid; other site 471852005128 ABC transporter signature motif; other site 471852005129 Walker B; other site 471852005130 D-loop; other site 471852005131 H-loop/switch region; other site 471852005132 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471852005133 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 471852005134 FtsX-like permease family; Region: FtsX; pfam02687 471852005135 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 471852005136 FtsX-like permease family; Region: FtsX; pfam02687 471852005137 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471852005138 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471852005139 Walker A/P-loop; other site 471852005140 ATP binding site [chemical binding]; other site 471852005141 Q-loop/lid; other site 471852005142 ABC transporter signature motif; other site 471852005143 Walker B; other site 471852005144 D-loop; other site 471852005145 H-loop/switch region; other site 471852005146 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852005147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852005148 active site 471852005149 phosphorylation site [posttranslational modification] 471852005150 intermolecular recognition site; other site 471852005151 dimerization interface [polypeptide binding]; other site 471852005152 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852005153 dimerization interface [polypeptide binding]; other site 471852005154 DNA binding residues [nucleotide binding] 471852005155 Histidine kinase; Region: HisKA_3; pfam07730 471852005156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852005157 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471852005158 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471852005159 active site 471852005160 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 471852005161 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 471852005162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852005163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852005164 S-adenosylmethionine binding site [chemical binding]; other site 471852005165 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 471852005166 proteasome ATPase; Region: pup_AAA; TIGR03689 471852005167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852005168 Walker A motif; other site 471852005169 ATP binding site [chemical binding]; other site 471852005170 Walker B motif; other site 471852005171 arginine finger; other site 471852005172 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 471852005173 Pup-ligase protein; Region: Pup_ligase; pfam03136 471852005174 Pup-like protein; Region: Pup; cl05289 471852005175 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 471852005176 active site 471852005177 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 471852005178 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 471852005179 active site 471852005180 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 471852005181 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 471852005182 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 471852005183 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 471852005184 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 471852005185 Predicted transcriptional regulator [Transcription]; Region: COG2378 471852005186 Predicted transcriptional regulator [Transcription]; Region: COG2378 471852005187 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 471852005188 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 471852005189 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 471852005190 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852005191 ATP binding site [chemical binding]; other site 471852005192 putative Mg++ binding site [ion binding]; other site 471852005193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852005194 nucleotide binding region [chemical binding]; other site 471852005195 ATP-binding site [chemical binding]; other site 471852005196 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 471852005197 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 471852005198 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471852005199 active site 471852005200 metal binding site 1 [ion binding]; metal-binding site 471852005201 putative 5' ssDNA interaction site; other site 471852005202 metal binding site 3; metal-binding site 471852005203 metal binding site 2 [ion binding]; metal-binding site 471852005204 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471852005205 putative DNA binding site [nucleotide binding]; other site 471852005206 putative metal binding site [ion binding]; other site 471852005207 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 471852005208 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 471852005209 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 471852005210 active site 471852005211 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471852005212 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 471852005213 Walker A/P-loop; other site 471852005214 ATP binding site [chemical binding]; other site 471852005215 Q-loop/lid; other site 471852005216 ABC transporter signature motif; other site 471852005217 Walker B; other site 471852005218 D-loop; other site 471852005219 H-loop/switch region; other site 471852005220 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471852005221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 471852005222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852005223 putative PBP binding loops; other site 471852005224 dimer interface [polypeptide binding]; other site 471852005225 ABC-ATPase subunit interface; other site 471852005226 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471852005227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852005228 putative PBP binding loops; other site 471852005229 dimer interface [polypeptide binding]; other site 471852005230 ABC-ATPase subunit interface; other site 471852005231 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471852005232 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 471852005233 Walker A/P-loop; other site 471852005234 ATP binding site [chemical binding]; other site 471852005235 Q-loop/lid; other site 471852005236 ABC transporter signature motif; other site 471852005237 Walker B; other site 471852005238 D-loop; other site 471852005239 H-loop/switch region; other site 471852005240 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471852005241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852005242 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471852005243 ligand binding site [chemical binding]; other site 471852005244 dimerization interface [polypeptide binding]; other site 471852005245 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471852005246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852005247 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852005248 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 471852005249 Haemolysin-III related; Region: HlyIII; cl03831 471852005250 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 471852005251 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471852005252 phosphopeptide binding site; other site 471852005253 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852005254 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852005255 active site 471852005256 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 471852005257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 471852005258 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 471852005259 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 471852005260 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471852005261 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471852005262 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852005263 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 471852005264 B12 binding site [chemical binding]; other site 471852005265 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471852005266 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 471852005267 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 471852005268 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 471852005269 putative active site [active] 471852005270 catalytic triad [active] 471852005271 putative dimer interface [polypeptide binding]; other site 471852005272 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 471852005273 Ligand binding site [chemical binding]; other site 471852005274 Putative Catalytic site [active] 471852005275 DXD motif; other site 471852005276 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 471852005277 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471852005278 active site 471852005279 metal binding site [ion binding]; metal-binding site 471852005280 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852005281 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 471852005282 Cation efflux family; Region: Cation_efflux; cl00316 471852005283 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 471852005284 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 471852005285 active site 471852005286 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471852005287 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 471852005288 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471852005289 mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965 471852005290 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471852005291 active site 471852005292 Creatinine amidohydrolase; Region: Creatininase; cl00618 471852005293 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 471852005294 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 471852005295 active site 471852005296 substrate binding site [chemical binding]; other site 471852005297 FMN binding site [chemical binding]; other site 471852005298 putative catalytic residues [active] 471852005299 radical SAM peptide maturase, mycofactocin system; Region: rSAM_MSMEG_1423; TIGR03962 471852005300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471852005301 FeS/SAM binding site; other site 471852005302 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 471852005303 mycofactocin system RPExFGAL proteinn; Region: Ac_RPExFGAL; TIGR03967 471852005304 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 471852005305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852005306 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471852005307 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 471852005308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852005309 Peptidase M14-like domain of carboxypeptidase (CP) T (CPT), CPT belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a...; Region: M14_CPT; cd03859 471852005310 putative active site [active] 471852005311 Zn-binding site [ion binding]; other site 471852005312 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 471852005313 active site 471852005314 putative catalytic site [active] 471852005315 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 471852005316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852005317 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 471852005318 classical (c) SDRs; Region: SDR_c; cd05233 471852005319 NAD(P) binding site [chemical binding]; other site 471852005320 active site 471852005321 enoyl-CoA hydratase; Provisional; Region: PRK05864 471852005322 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852005323 substrate binding site [chemical binding]; other site 471852005324 oxyanion hole (OAH) forming residues; other site 471852005325 trimer interface [polypeptide binding]; other site 471852005326 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 471852005327 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 471852005328 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 471852005329 putative active site [active] 471852005330 catalytic site [active] 471852005331 putative metal binding site [ion binding]; other site 471852005332 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471852005333 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 471852005334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852005335 S-adenosylmethionine binding site [chemical binding]; other site 471852005336 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471852005337 metal ion-dependent adhesion site (MIDAS); other site 471852005338 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471852005339 Protein of unknown function DUF58; Region: DUF58; pfam01882 471852005340 MoxR-like ATPases [General function prediction only]; Region: COG0714 471852005341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852005342 Walker A motif; other site 471852005343 ATP binding site [chemical binding]; other site 471852005344 Walker B motif; other site 471852005345 arginine finger; other site 471852005346 LysE type translocator; Region: LysE; cl00565 471852005347 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 471852005348 active site 471852005349 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471852005350 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 471852005351 DNA binding site [nucleotide binding] 471852005352 Int/Topo IB signature motif; other site 471852005353 active site 471852005354 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471852005355 DNA binding site [nucleotide binding] 471852005356 Int/Topo IB signature motif; other site 471852005357 active site 471852005358 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471852005359 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471852005360 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471852005361 catalytic residue [active] 471852005362 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471852005363 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852005364 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 471852005365 putative dimerization interface [polypeptide binding]; other site 471852005366 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471852005367 Phage integrase family; Region: Phage_integrase; pfam00589 471852005368 Int/Topo IB signature motif; other site 471852005369 active site 471852005370 DNA binding site [nucleotide binding] 471852005371 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 471852005372 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 471852005373 Uncharacterised BCR, COG1649; Region: DUF187; pfam02638 471852005374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852005375 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 471852005376 chorismate binding enzyme; Region: Chorismate_bind; cl10555 471852005377 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 471852005378 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 471852005379 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 471852005380 dimer interface [polypeptide binding]; other site 471852005381 tetramer interface [polypeptide binding]; other site 471852005382 PYR/PP interface [polypeptide binding]; other site 471852005383 TPP binding site [chemical binding]; other site 471852005384 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 471852005385 TPP-binding site; other site 471852005386 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway...; Region: OSBS; cd03320 471852005387 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 471852005388 active site 471852005389 naphthoate synthase; Validated; Region: PRK08321 471852005390 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852005391 substrate binding site [chemical binding]; other site 471852005392 oxyanion hole (OAH) forming residues; other site 471852005393 trimer interface [polypeptide binding]; other site 471852005394 AMP-binding enzyme; Region: AMP-binding; pfam00501 471852005395 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852005396 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471852005397 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 471852005398 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852005399 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471852005400 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852005401 DNA binding residues [nucleotide binding] 471852005402 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471852005403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852005404 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471852005405 Walker A/P-loop; other site 471852005406 ATP binding site [chemical binding]; other site 471852005407 Q-loop/lid; other site 471852005408 ABC transporter signature motif; other site 471852005409 Walker B; other site 471852005410 D-loop; other site 471852005411 H-loop/switch region; other site 471852005412 Protein of unknown function (DUF421); Region: DUF421; cl00990 471852005413 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 471852005414 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 471852005415 active site 471852005416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471852005417 DNA binding site [nucleotide binding] 471852005418 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain...; Region: Rieske_NirD; cd03529 471852005419 nitrite reductase subunit NirD; Provisional; Region: PRK14989 471852005420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852005421 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 471852005422 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 471852005423 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471852005424 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 471852005425 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 471852005426 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 471852005427 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 471852005428 [4Fe-4S] binding site [ion binding]; other site 471852005429 molybdopterin cofactor binding site; other site 471852005430 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of...; Region: MopB_CT_Fdh-Nap-like; cd00508 471852005431 molybdopterin cofactor binding site; other site 471852005432 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 471852005433 nudix motif; other site 471852005434 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 471852005435 DinB superfamily; Region: DinB_2; cl00986 471852005436 tetracycline repressor protein TetR; Provisional; Region: PRK13756 471852005437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852005438 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 471852005439 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 471852005440 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 471852005441 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 471852005442 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471852005443 Cysteine-rich domain; Region: CCG; pfam02754 471852005444 Cysteine-rich domain; Region: CCG; pfam02754 471852005445 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 471852005446 glycine dehydrogenase; Provisional; Region: PRK05367 471852005447 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 471852005448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852005449 tetramer interface [polypeptide binding]; other site 471852005450 catalytic residue [active] 471852005451 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 471852005452 tetramer interface [polypeptide binding]; other site 471852005453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852005454 catalytic residue [active] 471852005455 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471852005456 active site 471852005457 ATP binding site [chemical binding]; other site 471852005458 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 471852005459 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 471852005460 DNA binding residues [nucleotide binding] 471852005461 putative dimer interface [polypeptide binding]; other site 471852005462 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 471852005463 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 471852005464 DNA binding residues [nucleotide binding] 471852005465 Double zinc ribbon; Region: DZR; pfam12773 471852005466 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471852005467 phosphopeptide binding site; other site 471852005468 Cytochrome P450; Region: p450; cl12078 471852005469 Pectate lyase; Region: Pec_lyase_C; cl01593 471852005470 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 471852005471 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 471852005472 active site 471852005473 Substrate binding site [chemical binding]; other site 471852005474 Mg++ binding site [ion binding]; other site 471852005475 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 471852005476 putative trimer interface [polypeptide binding]; other site 471852005477 putative CoA binding site [chemical binding]; other site 471852005478 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 471852005479 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 471852005480 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471852005481 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 471852005482 dimer interface [polypeptide binding]; other site 471852005483 ADP-ribose binding site [chemical binding]; other site 471852005484 active site 471852005485 nudix motif; other site 471852005486 metal binding site [ion binding]; metal-binding site 471852005487 ThiC family; Region: ThiC; cl08031 471852005488 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 471852005489 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 471852005490 active site 471852005491 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852005492 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 471852005493 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 471852005494 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471852005495 catalytic residue [active] 471852005496 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 471852005497 substrate binding site [chemical binding]; other site 471852005498 ATP binding site [chemical binding]; other site 471852005499 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 471852005500 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 471852005501 tetramer interface [polypeptide binding]; other site 471852005502 heme binding pocket [chemical binding]; other site 471852005503 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 471852005504 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 471852005505 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 471852005506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852005507 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 471852005508 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852005509 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 471852005510 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 471852005511 NAD binding site [chemical binding]; other site 471852005512 catalytic Zn binding site [ion binding]; other site 471852005513 substrate binding site [chemical binding]; other site 471852005514 structural Zn binding site [ion binding]; other site 471852005515 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471852005516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852005517 Bacterial transcriptional regulator; Region: IclR; pfam01614 471852005518 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 471852005519 tetramer interface [polypeptide binding]; other site 471852005520 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 471852005521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852005522 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471852005523 anti sigma factor interaction site; other site 471852005524 regulatory phosphorylation site [posttranslational modification]; other site 471852005525 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 471852005526 putative ADP-binding pocket [chemical binding]; other site 471852005527 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852005528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852005529 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852005530 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471852005531 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471852005532 active site 471852005533 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 471852005534 putative hydrophobic ligand binding site [chemical binding]; other site 471852005535 protein interface [polypeptide binding]; other site 471852005536 gate; other site 471852005537 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852005538 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471852005539 substrate binding pocket [chemical binding]; other site 471852005540 Peptidase C26; Region: Peptidase_C26; pfam07722 471852005541 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 471852005542 catalytic triad [active] 471852005543 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 471852005544 heme-binding site [chemical binding]; other site 471852005545 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 471852005546 FAD binding pocket [chemical binding]; other site 471852005547 FAD binding motif [chemical binding]; other site 471852005548 phosphate binding motif [ion binding]; other site 471852005549 beta-alpha-beta structure motif; other site 471852005550 NAD binding pocket [chemical binding]; other site 471852005551 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 471852005552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471852005553 Histidine kinase; Region: HisKA_3; pfam07730 471852005554 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852005555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852005556 active site 471852005557 phosphorylation site [posttranslational modification] 471852005558 intermolecular recognition site; other site 471852005559 dimerization interface [polypeptide binding]; other site 471852005560 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852005561 DNA binding residues [nucleotide binding] 471852005562 dimerization interface [polypeptide binding]; other site 471852005563 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 471852005564 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 471852005565 Walker A/P-loop; other site 471852005566 ATP binding site [chemical binding]; other site 471852005567 Q-loop/lid; other site 471852005568 ABC transporter signature motif; other site 471852005569 Walker B; other site 471852005570 D-loop; other site 471852005571 H-loop/switch region; other site 471852005572 Thymidylate synthase complementing protein; Region: Thy1; cl03630 471852005573 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471852005574 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These...; Region: MopB_3; cd02766 471852005575 putative [4Fe-4S] binding site [ion binding]; other site 471852005576 putative molybdopterin cofactor binding site [chemical binding]; other site 471852005577 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 471852005578 putative molybdopterin cofactor binding site; other site 471852005579 anthranilate synthase; Provisional; Region: PRK13566 471852005580 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 471852005581 chorismate binding enzyme; Region: Chorismate_bind; cl10555 471852005582 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 471852005583 glutamine binding [chemical binding]; other site 471852005584 catalytic triad [active] 471852005585 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 471852005586 Zn binding site [ion binding]; other site 471852005587 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 471852005588 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852005589 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852005590 active site 471852005591 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 471852005592 active site 471852005593 putative catalytic site [active] 471852005594 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 471852005595 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 471852005596 putative active site [active] 471852005597 putative substrate binding site [chemical binding]; other site 471852005598 ATP binding site [chemical binding]; other site 471852005599 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 471852005600 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852005601 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852005602 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852005603 active site 471852005604 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471852005605 active site 471852005606 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471852005607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471852005608 non-specific DNA binding site [nucleotide binding]; other site 471852005609 salt bridge; other site 471852005610 sequence-specific DNA binding site [nucleotide binding]; other site 471852005611 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 471852005612 Domain of unknown function (DUF955); Region: DUF955; cl01076 471852005613 isocitrate lyase; Provisional; Region: PRK06498 471852005614 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 471852005615 tetramer interface [polypeptide binding]; other site 471852005616 active site 471852005617 Mg2+/Mn2+ binding site [ion binding]; other site 471852005618 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 471852005619 Protein of unknown function (DUF990); Region: DUF990; cl01496 471852005620 Protein of unknown function (DUF990); Region: DUF990; cl01496 471852005621 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471852005622 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852005623 Walker A/P-loop; other site 471852005624 ATP binding site [chemical binding]; other site 471852005625 Q-loop/lid; other site 471852005626 ABC transporter signature motif; other site 471852005627 Walker B; other site 471852005628 D-loop; other site 471852005629 H-loop/switch region; other site 471852005630 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471852005631 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 471852005632 NAD(P) binding site [chemical binding]; other site 471852005633 catalytic residues [active] 471852005634 LysE type translocator; Region: LysE; cl00565 471852005635 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 471852005636 enoyl-CoA hydratase; Provisional; Region: PRK05870 471852005637 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852005638 substrate binding site [chemical binding]; other site 471852005639 oxyanion hole (OAH) forming residues; other site 471852005640 trimer interface [polypeptide binding]; other site 471852005641 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852005642 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852005643 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852005644 active site 471852005645 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 471852005646 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471852005647 Coenzyme A binding pocket [chemical binding]; other site 471852005648 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852005649 membrane ATPase/protein kinase; Provisional; Region: PRK09435 471852005650 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 471852005651 Walker A; other site 471852005652 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 471852005653 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily...; Region: MM_CoA_mutase_alpha_like; cd03679 471852005654 active site 471852005655 substrate binding site [chemical binding]; other site 471852005656 coenzyme B12 binding site [chemical binding]; other site 471852005657 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 471852005658 B12 binding site [chemical binding]; other site 471852005659 cobalt ligand [ion binding]; other site 471852005660 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 471852005661 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 471852005662 heterodimer interface [polypeptide binding]; other site 471852005663 substrate interaction site [chemical binding]; other site 471852005664 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 471852005665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852005666 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 471852005667 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 471852005668 catalytic residues [active] 471852005669 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852005670 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471852005671 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852005672 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852005673 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852005674 active site 471852005675 Domain of unknown function (DUF385); Region: DUF385; cl04387 471852005676 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471852005677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852005678 DNA-binding site [nucleotide binding]; DNA binding site 471852005679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852005680 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 471852005681 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 471852005682 [2Fe-2S] cluster binding site [ion binding]; other site 471852005683 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471852005684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852005685 DNA-binding site [nucleotide binding]; DNA binding site 471852005686 FCD domain; Region: FCD; cl11656 471852005687 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852005688 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852005689 active site 471852005690 ATP binding site [chemical binding]; other site 471852005691 substrate binding site [chemical binding]; other site 471852005692 activation loop (A-loop); other site 471852005693 Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar4; cd09132 471852005694 putative active site [active] 471852005695 putative catalytic site [active] 471852005696 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 471852005697 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852005698 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471852005699 homodimer interface [polypeptide binding]; other site 471852005700 active site 471852005701 TDP-binding site; other site 471852005702 acceptor substrate-binding pocket; other site 471852005703 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852005704 active site 471852005705 ATP binding site [chemical binding]; other site 471852005706 substrate binding site [chemical binding]; other site 471852005707 activation loop (A-loop); other site 471852005708 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 471852005709 structural tetrad; other site 471852005710 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471852005711 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471852005712 catalytic residue [active] 471852005713 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852005714 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852005715 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852005716 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852005717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852005718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852005719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852005720 ATP binding site [chemical binding]; other site 471852005721 putative Mg++ binding site [ion binding]; other site 471852005722 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852005723 nucleotide binding region [chemical binding]; other site 471852005724 ATP-binding site [chemical binding]; other site 471852005725 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 471852005726 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 471852005727 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471852005728 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471852005729 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852005730 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 471852005731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 471852005732 binding surface 471852005733 TPR motif; other site 471852005734 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 471852005735 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 471852005736 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 471852005737 Cl- selectivity filter; other site 471852005738 Cl- binding residues [ion binding]; other site 471852005739 pore gating glutamate residue; other site 471852005740 dimer interface [polypeptide binding]; other site 471852005741 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cl10029 471852005742 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 471852005743 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852005744 Beta-Casp domain; Region: Beta-Casp; cl12567 471852005745 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 471852005746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852005747 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 471852005748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852005749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 471852005750 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 471852005751 uncharacterized xylulose kinase-like proteins, subgroup 2; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 471852005752 N- and C-terminal domain interface [polypeptide binding]; other site 471852005753 active site 471852005754 catalytic site [active] 471852005755 metal binding site [ion binding]; metal-binding site 471852005756 xylulose binding site [chemical binding]; other site 471852005757 ATP binding site [chemical binding]; other site 471852005758 putative homodimer interface [polypeptide binding]; other site 471852005759 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 471852005760 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471852005761 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471852005762 catalytic residue [active] 471852005763 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852005764 active site 471852005765 ATP binding site [chemical binding]; other site 471852005766 substrate binding site [chemical binding]; other site 471852005767 activation loop (A-loop); other site 471852005768 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852005769 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 471852005770 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 471852005771 acyl-CoA synthetase; Provisional; Region: PRK13391 471852005772 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852005773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852005774 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 471852005775 dimerization interface [polypeptide binding]; other site 471852005776 substrate binding pocket [chemical binding]; other site 471852005777 putative transporter; Provisional; Region: PRK10504 471852005778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852005779 putative substrate translocation pore; other site 471852005780 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 471852005781 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 471852005782 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 471852005783 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 471852005784 enoyl-CoA hydratase; Provisional; Region: PRK07511 471852005785 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 471852005786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852005787 short chain dehydrogenase; Provisional; Region: PRK07774 471852005788 classical (c) SDRs; Region: SDR_c; cd05233 471852005789 NAD(P) binding site [chemical binding]; other site 471852005790 active site 471852005791 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471852005792 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 471852005793 NAD binding site [chemical binding]; other site 471852005794 catalytic residues [active] 471852005795 Cytochrome P450; Region: p450; cl12078 471852005796 Cytochrome P450; Region: p450; cl12078 471852005797 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 471852005798 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852005799 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 471852005800 Phosphotransferase enzyme family; Region: APH; pfam01636 471852005801 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852005802 substrate binding site [chemical binding]; other site 471852005803 enoyl-CoA hydratase; Provisional; Region: PRK06688 471852005804 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852005805 substrate binding site [chemical binding]; other site 471852005806 oxyanion hole (OAH) forming residues; other site 471852005807 trimer interface [polypeptide binding]; other site 471852005808 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852005809 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 471852005810 FAD binding site [chemical binding]; other site 471852005811 homotetramer interface [polypeptide binding]; other site 471852005812 substrate binding pocket [chemical binding]; other site 471852005813 catalytic base [active] 471852005814 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471852005815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852005816 DNA-binding site [nucleotide binding]; DNA binding site 471852005817 FCD domain; Region: FCD; cl11656 471852005818 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471852005819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852005820 DNA-binding site [nucleotide binding]; DNA binding site 471852005821 FCD domain; Region: FCD; cl11656 471852005822 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 471852005823 active site 471852005824 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 471852005825 catalytic triad [active] 471852005826 dimer interface [polypeptide binding]; other site 471852005827 NADH dehydrogenase subunit 5; Provisional; Region: ND5; MTH00095 471852005828 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471852005829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 471852005830 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 471852005831 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 471852005832 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 471852005833 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471852005834 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852005835 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852005836 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 471852005837 active site 471852005838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852005839 H+ Antiporter protein; Region: 2A0121; TIGR00900 471852005840 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471852005841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852005842 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471852005843 CoenzymeA binding site [chemical binding]; other site 471852005844 subunit interaction site [polypeptide binding]; other site 471852005845 PHB binding site; other site 471852005846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 471852005847 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471852005848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 471852005849 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471852005850 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 471852005851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852005852 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471852005853 dimerization interface [polypeptide binding]; other site 471852005854 aspartate aminotransferase; Provisional; Region: PRK08361 471852005855 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471852005856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852005857 homodimer interface [polypeptide binding]; other site 471852005858 catalytic residue [active] 471852005859 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 471852005860 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 471852005861 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 471852005862 CGNR zinc finger; Region: zf-CGNR; pfam11706 471852005863 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 471852005864 Pterin binding enzyme; Region: Pterin_bind; pfam00809 471852005865 substrate binding pocket [chemical binding]; other site 471852005866 dimer interface [polypeptide binding]; other site 471852005867 inhibitor binding site; inhibition site 471852005868 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 471852005869 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 471852005870 NADP-binding site; other site 471852005871 homotetramer interface [polypeptide binding]; other site 471852005872 substrate binding site [chemical binding]; other site 471852005873 homodimer interface [polypeptide binding]; other site 471852005874 active site 471852005875 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 471852005876 Phosphotransferase enzyme family; Region: APH; pfam01636 471852005877 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852005878 active site 471852005879 substrate binding site [chemical binding]; other site 471852005880 ATP binding site [chemical binding]; other site 471852005881 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471852005882 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852005883 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471852005884 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 471852005885 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471852005886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852005887 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471852005888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852005889 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 471852005890 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471852005891 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 471852005892 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 471852005893 active site 471852005894 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471852005895 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471852005896 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471852005897 metal binding site [ion binding]; metal-binding site 471852005898 substrate binding pocket [chemical binding]; other site 471852005899 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 471852005900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852005901 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471852005902 catalytic residues [active] 471852005903 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 471852005904 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471852005905 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852005906 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471852005907 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852005908 DNA binding residues [nucleotide binding] 471852005909 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 471852005910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852005911 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471852005912 anti sigma factor interaction site; other site 471852005913 regulatory phosphorylation site [posttranslational modification]; other site 471852005914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852005915 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471852005916 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852005917 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852005918 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852005919 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852005920 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852005921 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852005922 GAF domain; Region: GAF; cl00853 471852005923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 471852005924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852005925 ATP binding site [chemical binding]; other site 471852005926 Mg2+ binding site [ion binding]; other site 471852005927 G-X-G motif; other site 471852005928 Response regulator receiver domain; Region: Response_reg; pfam00072 471852005929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852005930 active site 471852005931 phosphorylation site [posttranslational modification] 471852005932 intermolecular recognition site; other site 471852005933 dimerization interface [polypeptide binding]; other site 471852005934 Response regulator receiver domain; Region: Response_reg; pfam00072 471852005935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852005936 active site 471852005937 phosphorylation site [posttranslational modification] 471852005938 intermolecular recognition site; other site 471852005939 dimerization interface [polypeptide binding]; other site 471852005940 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 471852005941 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471852005942 active site 471852005943 HIGH motif; other site 471852005944 nucleotide binding site [chemical binding]; other site 471852005945 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471852005946 active site 471852005947 KMSKS motif; other site 471852005948 TIGR03086 family protein; Region: TIGR03086 471852005949 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 471852005950 putative active site [active] 471852005951 putative CoA binding site [chemical binding]; other site 471852005952 nudix motif; other site 471852005953 metal binding site [ion binding]; metal-binding site 471852005954 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 471852005955 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 471852005956 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 471852005957 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 471852005958 RNA binding site [nucleotide binding]; other site 471852005959 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 471852005960 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 471852005961 putative active site [active] 471852005962 putative substrate binding site [chemical binding]; other site 471852005963 ATP binding site [chemical binding]; other site 471852005964 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 471852005965 Predicted permease; Region: DUF318; cl00487 471852005966 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 471852005967 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 471852005968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852005969 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471852005970 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852005971 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471852005972 active site 471852005973 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 471852005974 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852005975 ATP binding site [chemical binding]; other site 471852005976 putative Mg++ binding site [ion binding]; other site 471852005977 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852005978 nucleotide binding region [chemical binding]; other site 471852005979 ATP-binding site [chemical binding]; other site 471852005980 Helicase associated domain (HA2); Region: HA2; cl04503 471852005981 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 471852005982 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 471852005983 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471852005984 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471852005985 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 471852005986 active site 471852005987 catalytic tetrad [active] 471852005988 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471852005989 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471852005990 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 471852005991 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 471852005992 Walker A/P-loop; other site 471852005993 ATP binding site [chemical binding]; other site 471852005994 Q-loop/lid; other site 471852005995 ABC transporter signature motif; other site 471852005996 Walker B; other site 471852005997 D-loop; other site 471852005998 H-loop/switch region; other site 471852005999 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 471852006000 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471852006001 TM-ABC transporter signature motif; other site 471852006002 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 471852006003 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 471852006004 Walker A/P-loop; other site 471852006005 ATP binding site [chemical binding]; other site 471852006006 Q-loop/lid; other site 471852006007 ABC transporter signature motif; other site 471852006008 Walker B; other site 471852006009 D-loop; other site 471852006010 H-loop/switch region; other site 471852006011 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 471852006012 putative ligand binding site [chemical binding]; other site 471852006013 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 471852006014 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 471852006015 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852006016 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 471852006017 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 471852006018 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 471852006019 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 471852006020 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 471852006021 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 471852006022 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 471852006023 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 471852006024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852006025 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852006026 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852006027 ATP binding site [chemical binding]; other site 471852006028 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 471852006029 classical (c) SDRs; Region: SDR_c; cd05233 471852006030 NAD(P) binding site [chemical binding]; other site 471852006031 active site 471852006032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852006033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852006034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852006035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852006036 enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase; Region: PLN02664 471852006037 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852006038 substrate binding site [chemical binding]; other site 471852006039 oxyanion hole (OAH) forming residues; other site 471852006040 trimer interface [polypeptide binding]; other site 471852006041 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471852006042 active site 471852006043 metal binding site [ion binding]; metal-binding site 471852006044 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 471852006045 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852006046 enoyl-CoA hydratase; Provisional; Region: PRK08272 471852006047 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852006048 substrate binding site [chemical binding]; other site 471852006049 oxyanion hole (OAH) forming residues; other site 471852006050 trimer interface [polypeptide binding]; other site 471852006051 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 471852006052 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852006053 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852006054 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471852006055 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852006056 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 471852006057 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852006058 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852006059 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 471852006060 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471852006061 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852006062 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852006063 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852006064 active site 471852006065 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 471852006066 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852006067 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852006068 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471852006069 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852006070 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471852006071 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852006072 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471852006073 active site 471852006074 metal binding site [ion binding]; metal-binding site 471852006075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852006076 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471852006077 NAD(P) binding site [chemical binding]; other site 471852006078 active site 471852006079 acetyl-CoA acetyltransferase; Validated; Region: PRK06157 471852006080 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 471852006081 active site 471852006082 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 471852006083 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 471852006084 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 471852006085 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471852006086 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471852006087 Walker A/P-loop; other site 471852006088 ATP binding site [chemical binding]; other site 471852006089 Q-loop/lid; other site 471852006090 ABC transporter signature motif; other site 471852006091 Walker B; other site 471852006092 D-loop; other site 471852006093 H-loop/switch region; other site 471852006094 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471852006095 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471852006096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852006097 dimer interface [polypeptide binding]; other site 471852006098 conserved gate region; other site 471852006099 putative PBP binding loops; other site 471852006100 ABC-ATPase subunit interface; other site 471852006101 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471852006102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852006103 dimer interface [polypeptide binding]; other site 471852006104 conserved gate region; other site 471852006105 putative PBP binding loops; other site 471852006106 ABC-ATPase subunit interface; other site 471852006107 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471852006108 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471852006109 Walker A/P-loop; other site 471852006110 ATP binding site [chemical binding]; other site 471852006111 Q-loop/lid; other site 471852006112 ABC transporter signature motif; other site 471852006113 Walker B; other site 471852006114 D-loop; other site 471852006115 H-loop/switch region; other site 471852006116 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471852006117 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471852006118 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 471852006119 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852006120 substrate binding site [chemical binding]; other site 471852006121 oxyanion hole (OAH) forming residues; other site 471852006122 trimer interface [polypeptide binding]; other site 471852006123 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471852006124 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471852006125 Flavin Reductases; Region: FlaRed; cl00801 471852006126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852006127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852006128 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 471852006129 putative active site [active] 471852006130 putative catalytic site [active] 471852006131 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 471852006132 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471852006133 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 471852006134 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471852006135 active site 471852006136 catalytic tetrad [active] 471852006137 TIR domain; Region: TIR; cl02060 471852006138 RecD/TraA family; Region: recD_rel; TIGR01448 471852006139 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471852006140 FAD binding domain; Region: FAD_binding_4; pfam01565 471852006141 Berberine and berberine like; Region: BBE; pfam08031 471852006142 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471852006143 RNA binding surface [nucleotide binding]; other site 471852006144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852006145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852006146 Domain of unknown function DUF; Region: DUF202; cl09954 471852006147 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471852006148 DoxX; Region: DoxX; cl00976 471852006149 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 471852006150 putative NAD(P) binding site [chemical binding]; other site 471852006151 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 471852006152 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471852006153 Creatinine amidohydrolase; Region: Creatininase; cl00618 471852006154 Sulfatase; Region: Sulfatase; cl10460 471852006155 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 471852006156 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471852006157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852006158 NAD(P) binding site [chemical binding]; other site 471852006159 active site 471852006160 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 471852006161 Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421 471852006162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852006163 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 471852006164 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 471852006165 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 471852006166 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 471852006167 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 471852006168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852006169 Walker A/P-loop; other site 471852006170 ATP binding site [chemical binding]; other site 471852006171 Q-loop/lid; other site 471852006172 ABC transporter signature motif; other site 471852006173 Walker B; other site 471852006174 D-loop; other site 471852006175 H-loop/switch region; other site 471852006176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852006177 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 471852006178 NAD(P) binding site [chemical binding]; other site 471852006179 active site 471852006180 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 471852006181 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 471852006182 substrate binding site [chemical binding]; other site 471852006183 tetramer interface [polypeptide binding]; other site 471852006184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852006185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852006186 substrate interface [chemical binding]; other site 471852006187 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 471852006188 YcaO-like family; Region: YcaO; cl09146 471852006189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471852006190 Histidine kinase; Region: HisKA_3; pfam07730 471852006191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471852006192 Histidine kinase; Region: HisKA_3; pfam07730 471852006193 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852006194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852006195 active site 471852006196 phosphorylation site [posttranslational modification] 471852006197 intermolecular recognition site; other site 471852006198 dimerization interface [polypeptide binding]; other site 471852006199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852006200 DNA binding residues [nucleotide binding] 471852006201 dimerization interface [polypeptide binding]; other site 471852006202 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 471852006203 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471852006204 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471852006205 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471852006206 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier...; Region: CLF; cd00832 471852006207 active site 471852006208 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471852006209 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471852006210 dimer interface [polypeptide binding]; other site 471852006211 active site 471852006212 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852006213 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471852006214 Walker A/P-loop; other site 471852006215 ATP binding site [chemical binding]; other site 471852006216 Q-loop/lid; other site 471852006217 ABC transporter signature motif; other site 471852006218 Walker B; other site 471852006219 D-loop; other site 471852006220 H-loop/switch region; other site 471852006221 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471852006222 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 471852006223 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471852006224 homodimer interface [polypeptide binding]; other site 471852006225 active site 471852006226 TDP-binding site; other site 471852006227 acceptor substrate-binding pocket; other site 471852006228 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 471852006229 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471852006230 inhibitor-cofactor binding pocket; inhibition site 471852006231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852006232 catalytic residue [active] 471852006233 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852006234 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471852006235 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471852006236 active site 471852006237 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 471852006238 putative hydrophobic ligand binding site [chemical binding]; other site 471852006239 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 471852006240 putative hydrophobic ligand binding site [chemical binding]; other site 471852006241 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 471852006242 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 471852006243 active site 471852006244 Acyl transferase domain; Region: Acyl_transf_1; cl08282 471852006245 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 471852006246 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 471852006247 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 471852006248 Enoylreductase; Region: PKS_ER; smart00829 471852006249 NAD(P) binding site [chemical binding]; other site 471852006250 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 471852006251 putative NADP binding site [chemical binding]; other site 471852006252 active site 471852006253 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852006254 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 471852006255 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 471852006256 active site 471852006257 Acyl transferase domain; Region: Acyl_transf_1; cl08282 471852006258 Acyl transferase domain; Region: Acyl_transf_1; cl08282 471852006259 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852006260 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 471852006261 Acyl transferase domain; Region: Acyl_transf_1; cl08282 471852006262 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 471852006263 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 471852006264 dimer interface [polypeptide binding]; other site 471852006265 active site 471852006266 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 471852006267 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852006268 hypothetical protein; Provisional; Region: PRK07538 471852006269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852006270 Cytochrome P450; Region: p450; cl12078 471852006271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852006272 S-adenosylmethionine binding site [chemical binding]; other site 471852006273 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471852006274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852006275 NAD(P) binding site [chemical binding]; other site 471852006276 active site 471852006277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852006278 active site 471852006279 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 471852006280 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471852006281 homodimer interface [polypeptide binding]; other site 471852006282 active site 471852006283 TDP-binding site; other site 471852006284 acceptor substrate-binding pocket; other site 471852006285 Cupin domain; Region: Cupin_2; cl09118 471852006286 Polyketide ketoreductase, classical (c) SDR; Region: PKR_SDR_c; cd08945 471852006287 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471852006288 NAD(P) binding site [chemical binding]; other site 471852006289 homodimer interface [polypeptide binding]; other site 471852006290 substrate binding site [chemical binding]; other site 471852006291 active site 471852006292 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852006293 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471852006294 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471852006295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852006296 S-adenosylmethionine binding site [chemical binding]; other site 471852006297 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 471852006298 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 471852006299 NAD binding site [chemical binding]; other site 471852006300 substrate binding site [chemical binding]; other site 471852006301 homodimer interface [polypeptide binding]; other site 471852006302 active site 471852006303 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 471852006304 putative hydrophobic ligand binding site [chemical binding]; other site 471852006305 CLM binding site; other site 471852006306 L1 loop; other site 471852006307 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 471852006308 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852006309 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471852006310 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 471852006311 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 471852006312 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471852006313 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 471852006314 G1 box; other site 471852006315 GTP/Mg2+ binding site [chemical binding]; other site 471852006316 G2 box; other site 471852006317 Switch I region; other site 471852006318 G3 box; other site 471852006319 Switch II region; other site 471852006320 G4 box; other site 471852006321 G5 box; other site 471852006322 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471852006323 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 471852006324 Nitrate and nitrite sensing; Region: NIT; pfam08376 471852006325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471852006326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852006327 ATP binding site [chemical binding]; other site 471852006328 Mg2+ binding site [ion binding]; other site 471852006329 G-X-G motif; other site 471852006330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852006331 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852006332 enoyl-CoA hydratase; Provisional; Region: PRK06210 471852006333 substrate binding site [chemical binding]; other site 471852006334 oxyanion hole (OAH) forming residues; other site 471852006335 trimer interface [polypeptide binding]; other site 471852006336 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 471852006337 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 471852006338 putative dimer interface [polypeptide binding]; other site 471852006339 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 471852006340 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 471852006341 NAD binding site [chemical binding]; other site 471852006342 substrate binding site [chemical binding]; other site 471852006343 catalytic Zn binding site [ion binding]; other site 471852006344 structural Zn binding site [ion binding]; other site 471852006345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 471852006346 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852006347 Active site [active] 471852006348 FOG: CBS domain [General function prediction only]; Region: COG0517 471852006349 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 471852006350 BON domain; Region: BON; cl02771 471852006351 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 471852006352 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 471852006353 substrate binding site [chemical binding]; other site 471852006354 active site 471852006355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471852006356 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 471852006357 GAF domain; Region: GAF; cl00853 471852006358 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 471852006359 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471852006360 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471852006361 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852006362 ATP binding site [chemical binding]; other site 471852006363 putative Mg++ binding site [ion binding]; other site 471852006364 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852006365 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 471852006366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852006367 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 471852006368 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 471852006369 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 471852006370 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 471852006371 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 471852006372 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 471852006373 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 471852006374 DNA binding residues [nucleotide binding] 471852006375 dimer interface [polypeptide binding]; other site 471852006376 [2Fe-2S] cluster binding site [ion binding]; other site 471852006377 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 471852006378 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 471852006379 active site 471852006380 substrate-binding site [chemical binding]; other site 471852006381 metal-binding site [ion binding] 471852006382 GTP binding site [chemical binding]; other site 471852006383 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 471852006384 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852006385 Walker A/P-loop; other site 471852006386 ATP binding site [chemical binding]; other site 471852006387 Q-loop/lid; other site 471852006388 ABC transporter signature motif; other site 471852006389 Walker B; other site 471852006390 D-loop; other site 471852006391 H-loop/switch region; other site 471852006392 TOBE domain; Region: TOBE_2; cl01440 471852006393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852006394 putative PBP binding loops; other site 471852006395 ABC-ATPase subunit interface; other site 471852006396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471852006397 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 471852006398 DNA binding residues [nucleotide binding] 471852006399 TOBE domain; Region: TOBE_2; cl01440 471852006400 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 471852006401 nudix motif; other site 471852006402 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 471852006403 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852006404 GTP/Mg2+ binding site [chemical binding]; other site 471852006405 G2 box; other site 471852006406 Switch I region; other site 471852006407 G3 box; other site 471852006408 Switch II region; other site 471852006409 G4 box; other site 471852006410 G5 box; other site 471852006411 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 471852006412 G1 box; other site 471852006413 GTP/Mg2+ binding site [chemical binding]; other site 471852006414 Switch I region; other site 471852006415 G2 box; other site 471852006416 G3 box; other site 471852006417 Switch II region; other site 471852006418 G4 box; other site 471852006419 G5 box; other site 471852006420 cytidylate kinase; Provisional; Region: cmk; PRK00023 471852006421 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852006422 prephenate dehydrogenase; Validated; Region: PRK06545 471852006423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852006424 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 471852006425 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In...; Region: AroH; cd02185 471852006426 homotrimer interaction site [polypeptide binding]; other site 471852006427 active site 471852006428 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 471852006429 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 471852006430 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 471852006431 active site 471852006432 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 471852006433 ScpA/B protein; Region: ScpA_ScpB; cl00598 471852006434 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471852006435 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 471852006436 P-loop; other site 471852006437 Magnesium ion binding site [ion binding]; other site 471852006438 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 471852006439 Magnesium ion binding site [ion binding]; other site 471852006440 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 471852006441 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471852006442 DNA binding site [nucleotide binding] 471852006443 Int/Topo IB signature motif; other site 471852006444 active site 471852006445 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 471852006446 dimer interface [polypeptide binding]; other site 471852006447 active site 471852006448 ADP-ribose binding site [chemical binding]; other site 471852006449 nudix motif; other site 471852006450 metal binding site [ion binding]; metal-binding site 471852006451 CTP synthetase; Validated; Region: pyrG; PRK05380 471852006452 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 471852006453 Catalytic site [active] 471852006454 Active site [active] 471852006455 UTP binding site [chemical binding]; other site 471852006456 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 471852006457 active site 471852006458 putative oxyanion hole; other site 471852006459 catalytic triad [active] 471852006460 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 471852006461 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852006462 lipid-transfer protein; Provisional; Region: PRK07855 471852006463 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 471852006464 active site 471852006465 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 471852006466 DUF35 OB-fold domain; Region: DUF35; pfam01796 471852006467 Nitronate monooxygenase; Region: NMO; pfam03060 471852006468 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 471852006469 FMN binding site [chemical binding]; other site 471852006470 substrate binding site [chemical binding]; other site 471852006471 putative catalytic residue [active] 471852006472 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 471852006473 active site 471852006474 catalytic triad [active] 471852006475 oxyanion hole [active] 471852006476 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471852006477 anti sigma factor interaction site; other site 471852006478 regulatory phosphorylation site [posttranslational modification]; other site 471852006479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852006480 excinuclease ABC subunit B; Provisional; Region: PRK05298 471852006481 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852006482 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852006483 nucleotide binding region [chemical binding]; other site 471852006484 ATP-binding site [chemical binding]; other site 471852006485 Ultra-violet resistance protein B; Region: UvrB; pfam12344 471852006486 UvrB/uvrC motif; Region: UVR; pfam02151 471852006487 Histidine kinase; Region: HisKA_3; pfam07730 471852006488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852006489 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 471852006490 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 471852006491 CoA-binding site [chemical binding]; other site 471852006492 ATP-binding [chemical binding]; other site 471852006493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471852006494 Coenzyme A binding pocket [chemical binding]; other site 471852006495 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471852006496 putative catalytic site [active] 471852006497 putative metal binding site [ion binding]; other site 471852006498 putative phosphate binding site [ion binding]; other site 471852006499 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 471852006500 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 471852006501 RNA binding site [nucleotide binding]; other site 471852006502 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 471852006503 RNA binding site [nucleotide binding]; other site 471852006504 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 471852006505 RNA binding site [nucleotide binding]; other site 471852006506 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 471852006507 RNA binding site [nucleotide binding]; other site 471852006508 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 471852006509 DNA polymerase I; Provisional; Region: PRK05755 471852006510 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471852006511 active site 471852006512 putative 5' ssDNA interaction site; other site 471852006513 metal binding site 3; metal-binding site 471852006514 metal binding site 1 [ion binding]; metal-binding site 471852006515 metal binding site 2 [ion binding]; metal-binding site 471852006516 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471852006517 putative DNA binding site [nucleotide binding]; other site 471852006518 putative metal binding site [ion binding]; other site 471852006519 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 471852006520 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 471852006521 active site 471852006522 DNA binding site [nucleotide binding] 471852006523 catalytic site [active] 471852006524 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471852006525 CoenzymeA binding site [chemical binding]; other site 471852006526 subunit interaction site [polypeptide binding]; other site 471852006527 PHB binding site; other site 471852006528 Telomeric repeat-binding factor 2; Region: TRF2; pfam11611 471852006529 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 471852006530 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 471852006531 Walker A/P-loop; other site 471852006532 ATP binding site [chemical binding]; other site 471852006533 Q-loop/lid; other site 471852006534 ABC transporter signature motif; other site 471852006535 Walker B; other site 471852006536 D-loop; other site 471852006537 H-loop/switch region; other site 471852006538 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 471852006539 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 471852006540 Walker A/P-loop; other site 471852006541 ATP binding site [chemical binding]; other site 471852006542 Q-loop/lid; other site 471852006543 ABC transporter signature motif; other site 471852006544 Walker B; other site 471852006545 D-loop; other site 471852006546 H-loop/switch region; other site 471852006547 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 471852006548 TM-ABC transporter signature motif; other site 471852006549 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 471852006550 TM-ABC transporter signature motif; other site 471852006551 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 471852006552 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 471852006553 dimerization interface [polypeptide binding]; other site 471852006554 ligand binding site [chemical binding]; other site 471852006555 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 471852006556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852006557 active site 471852006558 phosphorylation site [posttranslational modification] 471852006559 intermolecular recognition site; other site 471852006560 dimerization interface [polypeptide binding]; other site 471852006561 ANTAR domain; Region: ANTAR; cl04297 471852006562 pyruvate kinase; Provisional; Region: PRK06247 471852006563 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 471852006564 domain interfaces; other site 471852006565 active site 471852006566 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 471852006567 proposed catalytic triad [active] 471852006568 conserved cys residue [active] 471852006569 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471852006570 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 471852006571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852006572 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 471852006573 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 471852006574 active site 471852006575 dimer interface [polypeptide binding]; other site 471852006576 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 471852006577 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 471852006578 active site 471852006579 FMN binding site [chemical binding]; other site 471852006580 substrate binding site [chemical binding]; other site 471852006581 3Fe-4S cluster binding site [ion binding]; other site 471852006582 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 471852006583 domain interface; other site 471852006584 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 471852006585 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 471852006586 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471852006587 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 471852006588 Methylamine utilisation protein MauE; Region: MauE; pfam07291 471852006589 tryptophan synthase; Region: PLN02591 471852006590 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 471852006591 substrate binding site [chemical binding]; other site 471852006592 active site 471852006593 catalytic residues [active] 471852006594 heterodimer interface [polypeptide binding]; other site 471852006595 tryptophan synthase, beta chain; Region: PLN02618 471852006596 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 471852006597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852006598 catalytic residue [active] 471852006599 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 471852006600 active site 471852006601 ribulose/triose binding site [chemical binding]; other site 471852006602 phosphate binding site [ion binding]; other site 471852006603 substrate (anthranilate) binding pocket [chemical binding]; other site 471852006604 product (indole) binding pocket [chemical binding]; other site 471852006605 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 471852006606 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471852006607 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471852006608 DNA binding site [nucleotide binding] 471852006609 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 471852006610 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 471852006611 DNA-binding site [nucleotide binding]; DNA binding site 471852006612 RNA-binding motif; other site 471852006613 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471852006614 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852006615 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471852006616 Walker A/P-loop; other site 471852006617 ATP binding site [chemical binding]; other site 471852006618 Q-loop/lid; other site 471852006619 ABC transporter signature motif; other site 471852006620 Walker B; other site 471852006621 D-loop; other site 471852006622 H-loop/switch region; other site 471852006623 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 471852006624 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471852006625 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852006626 Walker A/P-loop; other site 471852006627 ATP binding site [chemical binding]; other site 471852006628 Q-loop/lid; other site 471852006629 ABC transporter signature motif; other site 471852006630 Walker B; other site 471852006631 D-loop; other site 471852006632 H-loop/switch region; other site 471852006633 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 471852006634 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852006635 active site 471852006636 Predicted acyl esterases [General function prediction only]; Region: COG2936 471852006637 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 471852006638 PhoD-like phosphatase; Region: PhoD; pfam09423 471852006639 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471852006640 putative active site [active] 471852006641 putative metal binding site [ion binding]; other site 471852006642 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471852006643 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 471852006644 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 471852006645 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 471852006646 substrate binding site [chemical binding]; other site 471852006647 glutamase interaction surface [polypeptide binding]; other site 471852006648 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 471852006649 homotrimer interaction site [polypeptide binding]; other site 471852006650 putative active site [active] 471852006651 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 471852006652 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 471852006653 catalytic residues [active] 471852006654 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 471852006655 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 471852006656 putative active site [active] 471852006657 oxyanion strand; other site 471852006658 catalytic triad [active] 471852006659 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 471852006660 putative active site pocket [active] 471852006661 4-fold oligomerization interface [polypeptide binding]; other site 471852006662 metal binding residues [ion binding]; metal-binding site 471852006663 3-fold/trimer interface [polypeptide binding]; other site 471852006664 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 471852006665 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471852006666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852006667 homodimer interface [polypeptide binding]; other site 471852006668 catalytic residue [active] 471852006669 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 471852006670 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 471852006671 NAD binding site [chemical binding]; other site 471852006672 dimerization interface [polypeptide binding]; other site 471852006673 product binding site; other site 471852006674 substrate binding site [chemical binding]; other site 471852006675 zinc binding site [ion binding]; other site 471852006676 catalytic residues [active] 471852006677 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 471852006678 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 471852006679 putative deacylase active site [active] 471852006680 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 471852006681 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471852006682 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471852006683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852006684 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 471852006685 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 471852006686 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 471852006687 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 471852006688 generic binding surface II; other site 471852006689 generic binding surface I; other site 471852006690 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 471852006691 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 471852006692 AzlC protein; Region: AzlC; cl00570 471852006693 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 471852006694 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 471852006695 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 471852006696 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 471852006697 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 471852006698 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 471852006699 active site 471852006700 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 471852006701 Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811 471852006702 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 471852006703 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471852006704 HIGH motif; other site 471852006705 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471852006706 active site 471852006707 KMSKS motif; other site 471852006708 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 471852006709 tRNA binding surface [nucleotide binding]; other site 471852006710 anticodon binding site; other site 471852006711 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 471852006712 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 471852006713 DivIVA domain; Region: DivI1A_domain; TIGR03544 471852006714 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 471852006715 Protein of unknown function (DUF552); Region: DUF552; cl00775 471852006716 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 471852006717 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471852006718 catalytic residue [active] 471852006719 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 471852006720 nucleotide binding site [chemical binding]; other site 471852006721 SulA interaction site; other site 471852006722 cell division protein FtsQ; Provisional; Region: PRK05529 471852006723 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 471852006724 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 471852006725 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471852006726 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471852006727 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471852006728 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 471852006729 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 471852006730 active site 471852006731 homodimer interface [polypeptide binding]; other site 471852006732 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 471852006733 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 471852006734 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471852006735 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 471852006736 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 471852006737 Mg++ binding site [ion binding]; other site 471852006738 putative catalytic motif [active] 471852006739 putative substrate binding site [chemical binding]; other site 471852006740 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471852006741 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 471852006742 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471852006743 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471852006744 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 471852006745 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471852006746 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471852006747 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471852006748 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471852006749 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471852006750 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 471852006751 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 471852006752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852006753 cell division protein MraZ; Reviewed; Region: PRK00326 471852006754 MraZ protein; Region: MraZ; pfam02381 471852006755 MraZ protein; Region: MraZ; pfam02381 471852006756 MoxR-like ATPases [General function prediction only]; Region: COG0714 471852006757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852006758 Walker A motif; other site 471852006759 ATP binding site [chemical binding]; other site 471852006760 Walker B motif; other site 471852006761 arginine finger; other site 471852006762 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471852006763 Protein of unknown function DUF58; Region: DUF58; pfam01882 471852006764 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 471852006765 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 471852006766 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471852006767 active site 471852006768 DNA polymerase IV; Validated; Region: PRK02406 471852006769 DNA binding site [nucleotide binding] 471852006770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852006771 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 471852006772 putative RNA binding site [nucleotide binding]; other site 471852006773 elongation factor P; Validated; Region: PRK00529 471852006774 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 471852006775 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 471852006776 RNA binding site [nucleotide binding]; other site 471852006777 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 471852006778 RNA binding site [nucleotide binding]; other site 471852006779 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 471852006780 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 471852006781 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 471852006782 active site 471852006783 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 471852006784 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471852006785 enoyl-CoA hydratase; Provisional; Region: PRK06213 471852006786 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852006787 substrate binding site [chemical binding]; other site 471852006788 oxyanion hole (OAH) forming residues; other site 471852006789 trimer interface [polypeptide binding]; other site 471852006790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852006791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852006792 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 471852006793 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 471852006794 trimer interface [polypeptide binding]; other site 471852006795 active site 471852006796 dimer interface [polypeptide binding]; other site 471852006797 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 471852006798 active site 471852006799 dimer interface [polypeptide binding]; other site 471852006800 metal binding site [ion binding]; metal-binding site 471852006801 shikimate kinase; Reviewed; Region: aroK; PRK00131 471852006802 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 471852006803 ADP binding site [chemical binding]; other site 471852006804 magnesium binding site [ion binding]; other site 471852006805 putative shikimate binding site; other site 471852006806 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 471852006807 Tetramer interface [polypeptide binding]; other site 471852006808 Active site [active] 471852006809 FMN-binding site [chemical binding]; other site 471852006810 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 471852006811 hypothetical protein; Provisional; Region: PRK08912 471852006812 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471852006813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852006814 homodimer interface [polypeptide binding]; other site 471852006815 catalytic residue [active] 471852006816 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852006817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852006818 active site 471852006819 phosphorylation site [posttranslational modification] 471852006820 intermolecular recognition site; other site 471852006821 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852006822 DNA binding residues [nucleotide binding] 471852006823 dimerization interface [polypeptide binding]; other site 471852006824 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471852006825 Histidine kinase; Region: HisKA_3; pfam07730 471852006826 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 471852006827 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471852006828 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471852006829 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471852006830 Walker A/P-loop; other site 471852006831 ATP binding site [chemical binding]; other site 471852006832 Q-loop/lid; other site 471852006833 ABC transporter signature motif; other site 471852006834 Walker B; other site 471852006835 D-loop; other site 471852006836 H-loop/switch region; other site 471852006837 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 471852006838 Predicted amidohydrolase [General function prediction only]; Region: COG0388 471852006839 putative active site [active] 471852006840 catalytic triad [active] 471852006841 putative dimer interface [polypeptide binding]; other site 471852006842 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471852006843 FAD binding domain; Region: FAD_binding_4; pfam01565 471852006844 Berberine and berberine like; Region: BBE; pfam08031 471852006845 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 471852006846 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471852006847 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 471852006848 Walker A/P-loop; other site 471852006849 ATP binding site [chemical binding]; other site 471852006850 Q-loop/lid; other site 471852006851 ABC transporter signature motif; other site 471852006852 Walker B; other site 471852006853 D-loop; other site 471852006854 H-loop/switch region; other site 471852006855 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471852006856 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 471852006857 Clp amino terminal domain; Region: Clp_N; pfam02861 471852006858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852006859 Walker A motif; other site 471852006860 ATP binding site [chemical binding]; other site 471852006861 Walker B motif; other site 471852006862 arginine finger; other site 471852006863 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852006864 Walker A motif; other site 471852006865 ATP binding site [chemical binding]; other site 471852006866 Walker B motif; other site 471852006867 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471852006868 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 471852006869 Sulfate transporter family; Region: Sulfate_transp; cl00967 471852006870 Permease family; Region: Xan_ur_permease; pfam00860 471852006871 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 471852006872 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 471852006873 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 471852006874 membrane protein FdrA; Validated; Region: PRK06091 471852006875 CoA-ligase; Region: Ligase_CoA; pfam00549 471852006876 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 471852006877 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 471852006878 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 471852006879 active site 471852006880 catalytic residues [active] 471852006881 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 471852006882 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 471852006883 Domain of unknown function (DUF385); Region: DUF385; cl04387 471852006884 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 471852006885 metal binding site [ion binding]; metal-binding site 471852006886 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 471852006887 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 471852006888 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 471852006889 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471852006890 metal ion-dependent adhesion site (MIDAS); other site 471852006891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852006892 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 471852006893 Walker A motif; other site 471852006894 ATP binding site [chemical binding]; other site 471852006895 Walker B motif; other site 471852006896 arginine finger; other site 471852006897 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 471852006898 Moco binding site; other site 471852006899 metal coordination site [ion binding]; other site 471852006900 dimerization interface [polypeptide binding]; other site 471852006901 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 471852006902 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471852006903 Protein of unknown function (DUF461); Region: DUF461; cl01071 471852006904 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 471852006905 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471852006906 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 471852006907 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 471852006908 Beta-lactamase; Region: Beta-lactamase; cl01009 471852006909 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471852006910 putative active site [active] 471852006911 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 471852006912 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 471852006913 ATP phosphoribosyltransferase; Region: HisG; cl15266 471852006914 HisG, C-terminal domain; Region: HisG_C; cl06867 471852006915 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 471852006916 homopentamer interface [polypeptide binding]; other site 471852006917 active site 471852006918 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 471852006919 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 471852006920 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 471852006921 dimerization interface [polypeptide binding]; other site 471852006922 active site 471852006923 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 471852006924 Lumazine binding domain; Region: Lum_binding; pfam00677 471852006925 Lumazine binding domain; Region: Lum_binding; pfam00677 471852006926 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 471852006927 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 471852006928 substrate binding site [chemical binding]; other site 471852006929 hexamer interface [polypeptide binding]; other site 471852006930 metal binding site [ion binding]; metal-binding site 471852006931 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 471852006932 active site 471852006933 16S rRNA methyltransferase B; Provisional; Region: PRK14902 471852006934 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 471852006935 putative RNA binding site [nucleotide binding]; other site 471852006936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852006937 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 471852006938 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 471852006939 putative active site [active] 471852006940 substrate binding site [chemical binding]; other site 471852006941 putative cosubstrate binding site; other site 471852006942 catalytic site [active] 471852006943 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 471852006944 substrate binding site [chemical binding]; other site 471852006945 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 471852006946 active site 471852006947 catalytic residues [active] 471852006948 metal binding site [ion binding]; metal-binding site 471852006949 primosome assembly protein PriA; Provisional; Region: PRK14873 471852006950 S-adenosylmethionine synthetase; Validated; Region: PRK05250 471852006951 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 471852006952 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 471852006953 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 471852006954 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 471852006955 Flavoprotein; Region: Flavoprotein; cl08021 471852006956 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 471852006957 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 471852006958 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 471852006959 catalytic site [active] 471852006960 G-X2-G-X-G-K; other site 471852006961 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 471852006962 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 471852006963 active site 471852006964 dimer interface [polypeptide binding]; other site 471852006965 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 471852006966 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 471852006967 heterodimer interface [polypeptide binding]; other site 471852006968 active site 471852006969 FMN binding site [chemical binding]; other site 471852006970 homodimer interface [polypeptide binding]; other site 471852006971 substrate binding site [chemical binding]; other site 471852006972 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 471852006973 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 471852006974 FAD binding pocket [chemical binding]; other site 471852006975 FAD binding motif [chemical binding]; other site 471852006976 phosphate binding motif [ion binding]; other site 471852006977 beta-alpha-beta structure motif; other site 471852006978 NAD binding pocket [chemical binding]; other site 471852006979 Iron coordination center [ion binding]; other site 471852006980 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 471852006981 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471852006982 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471852006983 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 471852006984 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471852006985 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471852006986 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 471852006987 IMP binding site; other site 471852006988 dimer interface [polypeptide binding]; other site 471852006989 interdomain contacts; other site 471852006990 partial ornithine binding site; other site 471852006991 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 471852006992 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 471852006993 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 471852006994 catalytic site [active] 471852006995 subunit interface [polypeptide binding]; other site 471852006996 dihydroorotase; Validated; Region: pyrC; PRK09357 471852006997 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 471852006998 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 471852006999 active site 471852007000 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 471852007001 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471852007002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852007003 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471852007004 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852007005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852007006 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471852007007 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471852007008 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471852007009 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 471852007010 putative deacylase active site [active] 471852007011 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 471852007012 catalytic residues [active] 471852007013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852007014 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 471852007015 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 471852007016 FAD binding site [chemical binding]; other site 471852007017 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471852007018 substrate binding pocket [chemical binding]; other site 471852007019 chain length determination region; other site 471852007020 substrate-Mg2+ binding site; other site 471852007021 catalytic residues [active] 471852007022 aspartate-rich region 1; other site 471852007023 active site lid residues [active] 471852007024 aspartate-rich region 2; other site 471852007025 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852007026 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852007027 active site 471852007028 ATP binding site [chemical binding]; other site 471852007029 substrate binding site [chemical binding]; other site 471852007030 activation loop (A-loop); other site 471852007031 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 471852007032 thiamine phosphate binding site [chemical binding]; other site 471852007033 active site 471852007034 pyrophosphate binding site [ion binding]; other site 471852007035 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 471852007036 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 471852007037 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 471852007038 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 471852007039 thiS-thiF/thiG interaction site; other site 471852007040 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 471852007041 ThiS interaction site; other site 471852007042 putative active site [active] 471852007043 tetramer interface [polypeptide binding]; other site 471852007044 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852007045 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852007046 active site 471852007047 ATP binding site [chemical binding]; other site 471852007048 substrate binding site [chemical binding]; other site 471852007049 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852007050 substrate binding site [chemical binding]; other site 471852007051 activation loop (A-loop); other site 471852007052 activation loop (A-loop); other site 471852007053 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 471852007054 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 471852007055 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 471852007056 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 471852007057 AP endonuclease family 2; Region: AP2Ec; smart00518 471852007058 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 471852007059 AP (apurinic/apyrimidinic) site pocket; other site 471852007060 DNA interaction; other site 471852007061 Metal-binding active site; metal-binding site 471852007062 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 471852007063 Moco binding site; other site 471852007064 metal coordination site [ion binding]; other site 471852007065 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 471852007066 NeuB family; Region: NeuB; cl00496 471852007067 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471852007068 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 471852007069 THUMP domain; Region: THUMP; cl12076 471852007070 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 471852007071 Ligand Binding Site [chemical binding]; other site 471852007072 6-phosphofructokinase; Provisional; Region: PRK03202 471852007073 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 471852007074 active site 471852007075 ADP/pyrophosphate binding site [chemical binding]; other site 471852007076 dimerization interface [polypeptide binding]; other site 471852007077 allosteric effector site; other site 471852007078 fructose-1,6-bisphosphate binding site; other site 471852007079 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471852007080 putative acyl-acceptor binding pocket; other site 471852007081 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471852007082 putative catalytic site [active] 471852007083 putative metal binding site [ion binding]; other site 471852007084 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471852007085 putative catalytic site [active] 471852007086 putative phosphate binding site [ion binding]; other site 471852007087 putative phosphate binding site [ion binding]; other site 471852007088 putative metal binding site [ion binding]; other site 471852007089 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 471852007090 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471852007091 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 471852007092 putative hydrophobic ligand binding site [chemical binding]; other site 471852007093 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471852007094 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471852007095 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471852007096 active site 471852007097 metal binding site [ion binding]; metal-binding site 471852007098 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 471852007099 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852007100 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852007101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852007102 NAD(P) binding site [chemical binding]; other site 471852007103 active site 471852007104 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 471852007105 Predicted outer membrane protein [Function unknown]; Region: COG3652 471852007106 Peptidase family M23; Region: Peptidase_M23; pfam01551 471852007107 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471852007108 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471852007109 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 471852007110 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 471852007111 Qi binding site; other site 471852007112 intrachain domain interface; other site 471852007113 interchain domain interface [polypeptide binding]; other site 471852007114 heme bH binding site [chemical binding]; other site 471852007115 heme bL binding site [chemical binding]; other site 471852007116 Qo binding site; other site 471852007117 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 471852007118 iron-sulfur cluster [ion binding]; other site 471852007119 [2Fe-2S] cluster binding site [ion binding]; other site 471852007120 Cytochrome c; Region: Cytochrom_C; cl11414 471852007121 Cytochrome c; Region: Cytochrom_C; cl11414 471852007122 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 471852007123 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 471852007124 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471852007125 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471852007126 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852007127 Rhomboid family; Region: Rhomboid; cl11446 471852007128 hypothetical protein; Validated; Region: PRK07883 471852007129 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471852007130 active site 471852007131 substrate binding site [chemical binding]; other site 471852007132 catalytic site [active] 471852007133 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471852007134 GIY-YIG motif/motif A; other site 471852007135 active site 471852007136 catalytic site [active] 471852007137 putative DNA binding site [nucleotide binding]; other site 471852007138 metal binding site [ion binding]; metal-binding site 471852007139 YacP-like NYN domain; Region: NYN_YacP; cl01491 471852007140 NlpC/P60 family; Region: NLPC_P60; cl11438 471852007141 NlpC/P60 family; Region: NLPC_P60; cl11438 471852007142 Plant Basic Secretory Protein; Region: BSP; pfam04450 471852007143 Peptidase family M48; Region: Peptidase_M48; cl12018 471852007144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 471852007145 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471852007146 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 471852007147 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 471852007148 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 471852007149 D-pathway; other site 471852007150 Putative ubiquinol binding site [chemical binding]; other site 471852007151 Low-spin heme (heme b) binding site [chemical binding]; other site 471852007152 Putative water exit pathway; other site 471852007153 Binuclear center (heme o3/CuB) [ion binding]; other site 471852007154 K-pathway; other site 471852007155 Putative proton exit pathway; other site 471852007156 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 471852007157 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 471852007158 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471852007159 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471852007160 catalytic residue [active] 471852007161 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 471852007162 CPxP motif; other site 471852007163 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 471852007164 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 471852007165 substrate binding site [chemical binding]; other site 471852007166 ATP binding site [chemical binding]; other site 471852007167 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 471852007168 Quinolinate synthetase A protein; Region: NadA; cl00420 471852007169 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 471852007170 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 471852007171 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471852007172 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 471852007173 active site 471852007174 catalytic tetrad [active] 471852007175 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852007176 Walker A motif; other site 471852007177 ATP binding site [chemical binding]; other site 471852007178 Walker B motif; other site 471852007179 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471852007180 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 471852007181 interface (dimer of trimers) [polypeptide binding]; other site 471852007182 Substrate-binding/catalytic site; other site 471852007183 Zn-binding sites [ion binding]; other site 471852007184 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 471852007185 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl10040 471852007186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852007187 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471852007188 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471852007189 E3 interaction surface; other site 471852007190 lipoyl attachment site [posttranslational modification]; other site 471852007191 e3 binding domain; Region: E3_binding; pfam02817 471852007192 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 471852007193 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 471852007194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852007195 TIGR01777 family protein; Region: yfcH 471852007196 NAD(P) binding site [chemical binding]; other site 471852007197 active site 471852007198 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 471852007199 active site pocket [active] 471852007200 oxyanion hole [active] 471852007201 catalytic triad [active] 471852007202 active site nucleophile [active] 471852007203 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 471852007204 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 471852007205 Domain of unknown function (DUF74); Region: DUF74; cl00426 471852007206 lipoyl synthase; Provisional; Region: PRK05481 471852007207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471852007208 FeS/SAM binding site; other site 471852007209 RDD family; Region: RDD; cl00746 471852007210 glutamine synthetase, type I; Region: GlnA; TIGR00653 471852007211 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471852007212 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471852007213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852007214 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 471852007215 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471852007216 metal binding triad; other site 471852007217 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471852007218 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471852007219 metal binding triad; other site 471852007220 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471852007221 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 471852007222 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471852007223 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471852007224 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 471852007225 substrate binding pocket [chemical binding]; other site 471852007226 substrate-Mg2+ binding site; other site 471852007227 aspartate-rich region 1; other site 471852007228 aspartate-rich region 2; other site 471852007229 NAD synthetase; Provisional; Region: PRK13981 471852007230 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 471852007231 multimer interface [polypeptide binding]; other site 471852007232 active site 471852007233 catalytic triad [active] 471852007234 protein interface 1 [polypeptide binding]; other site 471852007235 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 471852007236 homodimer interface [polypeptide binding]; other site 471852007237 NAD binding pocket [chemical binding]; other site 471852007238 ATP binding pocket [chemical binding]; other site 471852007239 Mg binding site [ion binding]; other site 471852007240 active-site loop [active] 471852007241 PAS fold; Region: PAS; pfam00989 471852007242 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471852007243 putative active site [active] 471852007244 heme pocket [chemical binding]; other site 471852007245 GAF domain; Region: GAF; cl00853 471852007246 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 471852007247 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471852007248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852007249 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 471852007250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852007251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852007252 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 471852007253 oligomerization interface [polypeptide binding]; other site 471852007254 active site 471852007255 metal binding site [ion binding]; metal-binding site 471852007256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852007257 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 471852007258 Putative cyclase; Region: Cyclase; cl00814 471852007259 methionine aminopeptidase; Reviewed; Region: PRK07281 471852007260 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471852007261 active site 471852007262 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 471852007263 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 471852007264 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471852007265 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117 471852007266 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852007267 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 471852007268 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 471852007269 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852007270 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471852007271 Copper resistance protein D; Region: CopD; cl00563 471852007272 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 471852007273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852007274 transcriptional regulator MalT; Provisional; Region: PRK04841 471852007275 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)...; Region: TLP_HIUase; cd05822 471852007276 active site 471852007277 homotetramer interface [polypeptide binding]; other site 471852007278 Sulfate transporter family; Region: Sulfate_transp; cl00967 471852007279 Permease family; Region: Xan_ur_permease; pfam00860 471852007280 Glycerate kinase family; Region: Gly_kinase; cl00841 471852007281 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 471852007282 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 471852007283 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 471852007284 NAD(P) binding site [chemical binding]; other site 471852007285 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471852007286 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471852007287 catalytic core [active] 471852007288 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 471852007289 putative homotetramer interface [polypeptide binding]; other site 471852007290 putative homodimer interface [polypeptide binding]; other site 471852007291 putative allosteric switch controlling residues; other site 471852007292 putative metal binding site [ion binding]; other site 471852007293 putative homodimer-homodimer interface [polypeptide binding]; other site 471852007294 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 471852007295 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 471852007296 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 471852007297 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 471852007298 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 471852007299 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 471852007300 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 471852007301 nudix motif; other site 471852007302 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 471852007303 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471852007304 anti sigma factor interaction site; other site 471852007305 regulatory phosphorylation site [posttranslational modification]; other site 471852007306 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 471852007307 Domain of unknown function DUF77; Region: DUF77; cl00307 471852007308 CrcB-like protein; Region: CRCB; cl09114 471852007309 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 471852007310 Erythromycin esterase; Region: Erythro_esteras; pfam05139 471852007311 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 471852007312 substrate binding site [chemical binding]; other site 471852007313 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 471852007314 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 471852007315 dimer interface [polypeptide binding]; other site 471852007316 active site 471852007317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 471852007318 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471852007319 Serine carboxypeptidase S28; Region: Peptidase_S28; cl15279 471852007320 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471852007321 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471852007322 active site 471852007323 metal binding site [ion binding]; metal-binding site 471852007324 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 471852007325 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852007326 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 471852007327 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 471852007328 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 471852007329 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 471852007330 structural tetrad; other site 471852007331 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 471852007332 structural tetrad; other site 471852007333 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 471852007334 structural tetrad; other site 471852007335 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 471852007336 structural tetrad; other site 471852007337 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852007338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852007339 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852007340 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 471852007341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852007342 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471852007343 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 471852007344 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 471852007345 Walker A/P-loop; other site 471852007346 ATP binding site [chemical binding]; other site 471852007347 Q-loop/lid; other site 471852007348 ABC transporter signature motif; other site 471852007349 Walker B; other site 471852007350 D-loop; other site 471852007351 H-loop/switch region; other site 471852007352 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 471852007353 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 471852007354 Walker A/P-loop; other site 471852007355 ATP binding site [chemical binding]; other site 471852007356 Q-loop/lid; other site 471852007357 ABC transporter signature motif; other site 471852007358 Walker B; other site 471852007359 D-loop; other site 471852007360 H-loop/switch region; other site 471852007361 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 471852007362 TM-ABC transporter signature motif; other site 471852007363 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 471852007364 TM-ABC transporter signature motif; other site 471852007365 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 471852007366 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471852007367 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 471852007368 Sodium:solute symporter family; Region: SSF; cl00456 471852007369 Protein of unknown function, DUF485; Region: DUF485; cl01231 471852007370 RDD family; Region: RDD; cl00746 471852007371 Sodium:solute symporter family; Region: SSF; cl00456 471852007372 Sodium:solute symporter family; Region: SSF; cl00456 471852007373 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471852007374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852007375 active site 471852007376 phosphorylation site [posttranslational modification] 471852007377 intermolecular recognition site; other site 471852007378 dimerization interface [polypeptide binding]; other site 471852007379 LytTr DNA-binding domain; Region: LytTR; cl04498 471852007380 GAF domain; Region: GAF; cl00853 471852007381 Histidine kinase; Region: His_kinase; pfam06580 471852007382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852007383 ATP binding site [chemical binding]; other site 471852007384 Mg2+ binding site [ion binding]; other site 471852007385 G-X-G motif; other site 471852007386 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 471852007387 amidase catalytic site [active] 471852007388 Zn binding residues [ion binding]; other site 471852007389 substrate binding site [chemical binding]; other site 471852007390 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471852007391 putative catalytic site [active] 471852007392 putative metal binding site [ion binding]; other site 471852007393 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471852007394 putative catalytic site [active] 471852007395 putative phosphate binding site [ion binding]; other site 471852007396 putative phosphate binding site [ion binding]; other site 471852007397 putative metal binding site [ion binding]; other site 471852007398 Jacalin-like lectin domains of putative endonucleases/exonucleases/phosphatases and related proteins; Region: Jacalin_EEP; cd09615 471852007399 putative sugar binding site [chemical binding]; other site 471852007400 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852007401 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471852007402 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471852007403 active site residue [active] 471852007404 hypothetical protein; Provisional; Region: PRK07877 471852007405 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471852007406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471852007407 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471852007408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471852007409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471852007410 motif II; other site 471852007411 LysE type translocator; Region: LysE; cl00565 471852007412 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 471852007413 putative homodimer interface [polypeptide binding]; other site 471852007414 putative active site [active] 471852007415 catalytic site [active] 471852007416 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471852007417 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852007418 ATP binding site [chemical binding]; other site 471852007419 putative Mg++ binding site [ion binding]; other site 471852007420 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852007421 nucleotide binding region [chemical binding]; other site 471852007422 ATP-binding site [chemical binding]; other site 471852007423 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 471852007424 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 471852007425 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 471852007426 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 471852007427 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 471852007428 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 471852007429 putative metal binding site [ion binding]; other site 471852007430 Integral membrane protein TerC family; Region: TerC; cl10468 471852007431 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 471852007432 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 471852007433 putative metal binding site [ion binding]; other site 471852007434 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 471852007435 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 471852007436 putative metal binding site [ion binding]; other site 471852007437 Domain of unknown function (DUF74); Region: DUF74; cl00426 471852007438 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 471852007439 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471852007440 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852007441 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471852007442 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852007443 DNA binding residues [nucleotide binding] 471852007444 DNA primase; Validated; Region: dnaG; PRK05667 471852007445 CHC2 zinc finger; Region: zf-CHC2; cl02597 471852007446 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 471852007447 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 471852007448 active site 471852007449 metal binding site [ion binding]; metal-binding site 471852007450 interdomain interaction site; other site 471852007451 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 471852007452 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 471852007453 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 471852007454 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 471852007455 homotrimer interaction site [polypeptide binding]; other site 471852007456 putative active site [active] 471852007457 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 471852007458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852007459 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 471852007460 alpha-gamma subunit interface [polypeptide binding]; other site 471852007461 beta-gamma subunit interface [polypeptide binding]; other site 471852007462 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 471852007463 gamma-beta subunit interface [polypeptide binding]; other site 471852007464 alpha-beta subunit interface [polypeptide binding]; other site 471852007465 urease subunit alpha; Reviewed; Region: ureC; PRK13206 471852007466 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 471852007467 subunit interactions [polypeptide binding]; other site 471852007468 active site 471852007469 flap region; other site 471852007470 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852007471 UreD urease accessory protein; Region: UreD; cl00530 471852007472 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 471852007473 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 471852007474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852007475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852007476 GtrA-like protein; Region: GtrA; cl00971 471852007477 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 471852007478 active site 471852007479 Trp docking motif; other site 471852007480 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471852007481 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 471852007482 putative active site [active] 471852007483 pyruvate phosphate dikinase; Provisional; Region: PRK09279 471852007484 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 471852007485 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 471852007486 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 471852007487 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 471852007488 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 471852007489 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 471852007490 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 471852007491 Protein export membrane protein; Region: SecD_SecF; cl14618 471852007492 Protein export membrane protein; Region: SecD_SecF; cl14618 471852007493 glycyl-tRNA synthetase; Provisional; Region: PRK04173 471852007494 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 471852007495 dimer interface [polypeptide binding]; other site 471852007496 motif 1; other site 471852007497 active site 471852007498 motif 2; other site 471852007499 motif 3; other site 471852007500 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 471852007501 anticodon binding site; other site 471852007502 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 471852007503 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 471852007504 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 471852007505 intersubunit interface [polypeptide binding]; other site 471852007506 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 471852007507 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471852007508 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 471852007509 ABC-ATPase subunit interface; other site 471852007510 dimer interface [polypeptide binding]; other site 471852007511 putative PBP binding regions; other site 471852007512 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471852007513 metal binding site 2 [ion binding]; metal-binding site 471852007514 putative DNA binding helix; other site 471852007515 metal binding site 1 [ion binding]; metal-binding site 471852007516 dimer interface [polypeptide binding]; other site 471852007517 structural Zn2+ binding site [ion binding]; other site 471852007518 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 471852007519 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 471852007520 catalytic residue [active] 471852007521 putative FPP diphosphate binding site; other site 471852007522 putative FPP binding hydrophobic cleft; other site 471852007523 dimer interface [polypeptide binding]; other site 471852007524 putative IPP diphosphate binding site; other site 471852007525 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 471852007526 Recombination protein O N terminal; Region: RecO_N; pfam11967 471852007527 Recombination protein O C terminal; Region: RecO_C; pfam02565 471852007528 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 471852007529 active site 471852007530 Zn binding site [ion binding]; other site 471852007531 2-isopropylmalate synthase; Validated; Region: PRK03739 471852007532 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 471852007533 active site 471852007534 catalytic residues [active] 471852007535 metal binding site [ion binding]; metal-binding site 471852007536 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 471852007537 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 471852007538 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 471852007539 Walker A/P-loop; other site 471852007540 ATP binding site [chemical binding]; other site 471852007541 Q-loop/lid; other site 471852007542 ABC transporter signature motif; other site 471852007543 Walker B; other site 471852007544 D-loop; other site 471852007545 H-loop/switch region; other site 471852007546 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 471852007547 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 471852007548 Walker A/P-loop; other site 471852007549 ATP binding site [chemical binding]; other site 471852007550 Q-loop/lid; other site 471852007551 ABC transporter signature motif; other site 471852007552 Walker B; other site 471852007553 D-loop; other site 471852007554 H-loop/switch region; other site 471852007555 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 471852007556 TM-ABC transporter signature motif; other site 471852007557 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 471852007558 TM-ABC transporter signature motif; other site 471852007559 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 471852007560 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 471852007561 putative ligand binding site [chemical binding]; other site 471852007562 Amidinotransferase; Region: Amidinotransf; cl12043 471852007563 GTPase Era; Reviewed; Region: era; PRK00089 471852007564 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 471852007565 G1 box; other site 471852007566 GTP/Mg2+ binding site [chemical binding]; other site 471852007567 Switch I region; other site 471852007568 G2 box; other site 471852007569 Switch II region; other site 471852007570 G3 box; other site 471852007571 G4 box; other site 471852007572 G5 box; other site 471852007573 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 471852007574 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 471852007575 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471852007576 Domain of unknown function DUF21; Region: DUF21; pfam01595 471852007577 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471852007578 Transporter associated domain; Region: CorC_HlyC; cl08393 471852007579 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 471852007580 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 471852007581 PhoH-like protein; Region: PhoH; cl12134 471852007582 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 471852007583 nucleotide binding site/active site [active] 471852007584 HIT family signature motif; other site 471852007585 catalytic residue [active] 471852007586 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471852007587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852007588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852007589 DNA binding residues [nucleotide binding] 471852007590 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 471852007591 chaperone protein DnaJ; Provisional; Region: PRK14278 471852007592 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 471852007593 HSP70 interaction site [polypeptide binding]; other site 471852007594 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 471852007595 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 471852007596 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 471852007597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852007598 HrcA protein C terminal domain; Region: HrcA; pfam01628 471852007599 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 471852007600 coproporphyrinogen III oxidase; Validated; Region: PRK05628 471852007601 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 471852007602 HemN C-terminal region; Region: HemN_C; pfam06969 471852007603 Protein of unknown function, DUF600; Region: DUF600; cl04640 471852007604 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471852007605 putative active site [active] 471852007606 GTP-binding protein LepA; Provisional; Region: PRK05433 471852007607 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 471852007608 G1 box; other site 471852007609 putative GEF interaction site [polypeptide binding]; other site 471852007610 GTP/Mg2+ binding site [chemical binding]; other site 471852007611 Switch I region; other site 471852007612 G2 box; other site 471852007613 G3 box; other site 471852007614 Switch II region; other site 471852007615 G4 box; other site 471852007616 G5 box; other site 471852007617 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 471852007618 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 471852007619 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 471852007620 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 471852007621 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 471852007622 putative hydrophobic ligand binding site [chemical binding]; other site 471852007623 hypothetical protein; Reviewed; Region: PRK07914 471852007624 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 471852007625 Competence protein; Region: Competence; cl00471 471852007626 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852007627 SLBB domain; Region: SLBB; pfam10531 471852007628 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 471852007629 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471852007630 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471852007631 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 471852007632 active site 471852007633 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 471852007634 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 471852007635 G1 box; other site 471852007636 GTP/Mg2+ binding site [chemical binding]; other site 471852007637 Switch I region; other site 471852007638 G2 box; other site 471852007639 G3 box; other site 471852007640 Switch II region; other site 471852007641 G4 box; other site 471852007642 G5 box; other site 471852007643 malate synthase A; Region: malate_syn_A; TIGR01344 471852007644 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 471852007645 active site 471852007646 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 471852007647 FAD binding domain; Region: FAD_binding_4; pfam01565 471852007648 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471852007649 FAD binding domain; Region: FAD_binding_4; pfam01565 471852007650 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 471852007651 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 471852007652 Cysteine-rich domain; Region: CCG; pfam02754 471852007653 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 471852007654 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471852007655 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471852007656 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471852007657 Walker A/P-loop; other site 471852007658 ATP binding site [chemical binding]; other site 471852007659 Q-loop/lid; other site 471852007660 ABC transporter signature motif; other site 471852007661 Walker B; other site 471852007662 D-loop; other site 471852007663 H-loop/switch region; other site 471852007664 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471852007665 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 471852007666 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471852007667 Walker A/P-loop; other site 471852007668 ATP binding site [chemical binding]; other site 471852007669 Q-loop/lid; other site 471852007670 ABC transporter signature motif; other site 471852007671 Walker B; other site 471852007672 D-loop; other site 471852007673 H-loop/switch region; other site 471852007674 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471852007675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852007676 dimer interface [polypeptide binding]; other site 471852007677 conserved gate region; other site 471852007678 putative PBP binding loops; other site 471852007679 ABC-ATPase subunit interface; other site 471852007680 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471852007681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 471852007682 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471852007683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471852007684 Histidine kinase; Region: HisKA_3; pfam07730 471852007685 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 471852007686 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 471852007687 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 471852007688 IPP transferase; Region: IPPT; cl00403 471852007689 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 471852007690 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 471852007691 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471852007692 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471852007693 FeS/SAM binding site; other site 471852007694 TRAM domain; Region: TRAM; cl01282 471852007695 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471852007696 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 471852007697 Walker A/P-loop; other site 471852007698 ATP binding site [chemical binding]; other site 471852007699 Q-loop/lid; other site 471852007700 ABC transporter signature motif; other site 471852007701 Walker B; other site 471852007702 D-loop; other site 471852007703 H-loop/switch region; other site 471852007704 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 471852007705 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 471852007706 substrate binding pocket [chemical binding]; other site 471852007707 membrane-bound complex binding site; other site 471852007708 hinge residues; other site 471852007709 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471852007710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852007711 dimer interface [polypeptide binding]; other site 471852007712 conserved gate region; other site 471852007713 putative PBP binding loops; other site 471852007714 ABC-ATPase subunit interface; other site 471852007715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852007716 putative PBP binding loops; other site 471852007717 ABC-ATPase subunit interface; other site 471852007718 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471852007719 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852007720 phosphodiesterase; Provisional; Region: PRK12704 471852007721 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471852007722 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471852007723 RecX family; Region: RecX; cl00936 471852007724 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852007725 Walker A motif; other site 471852007726 ATP binding site [chemical binding]; other site 471852007727 Walker B motif; other site 471852007728 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 471852007729 thioester formation/cholesterol transfer; other site 471852007730 protein-splicing catalytic site; other site 471852007731 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 471852007732 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl09966 471852007733 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852007734 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 471852007735 Predicted transcriptional regulator [Transcription]; Region: COG1959 471852007736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852007737 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 471852007738 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 471852007739 putative DNA binding site [nucleotide binding]; other site 471852007740 catalytic residue [active] 471852007741 putative H2TH interface [polypeptide binding]; other site 471852007742 putative catalytic residues [active] 471852007743 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471852007744 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 471852007745 Ferritin-like domain; Region: Ferritin; pfam00210 471852007746 dimerization interface [polypeptide binding]; other site 471852007747 DPS ferroxidase diiron center [ion binding]; other site 471852007748 ion pore; other site 471852007749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852007750 competence damage-inducible protein A; Provisional; Region: PRK00549 471852007751 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 471852007752 putative MPT binding site; other site 471852007753 Competence-damaged protein; Region: CinA; cl00666 471852007754 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471852007755 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 471852007756 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471852007757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471852007758 FeS/SAM binding site; other site 471852007759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852007760 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852007761 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 471852007762 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 471852007763 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852007764 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 471852007765 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 471852007766 dimer interface [polypeptide binding]; other site 471852007767 active site 471852007768 catalytic residue [active] 471852007769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852007770 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471852007771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852007772 putative substrate translocation pore; other site 471852007773 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 471852007774 UbiA prenyltransferase family; Region: UbiA; cl00337 471852007775 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 471852007776 ligand binding site [chemical binding]; other site 471852007777 active site 471852007778 UGI interface [polypeptide binding]; other site 471852007779 catalytic site [active] 471852007780 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471852007781 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 471852007782 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 471852007783 dihydrodipicolinate reductase; Provisional; Region: PRK00048 471852007784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852007785 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 471852007786 Membrane protein of unknown function; Region: DUF360; cl00850 471852007787 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471852007788 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471852007789 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471852007790 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 471852007791 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 471852007792 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 471852007793 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 471852007794 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 471852007795 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 471852007796 putative nucleic acid binding region [nucleotide binding]; other site 471852007797 G-X-X-G motif; other site 471852007798 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 471852007799 RNA binding site [nucleotide binding]; other site 471852007800 domain interface; other site 471852007801 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 471852007802 16S/18S rRNA binding site [nucleotide binding]; other site 471852007803 S13e-L30e interaction site [polypeptide binding]; other site 471852007804 25S rRNA binding site [nucleotide binding]; other site 471852007805 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 471852007806 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 471852007807 active site 471852007808 Riboflavin kinase; Region: Flavokinase; cl03312 471852007809 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 471852007810 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 471852007811 RNA binding site [nucleotide binding]; other site 471852007812 active site 471852007813 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 471852007814 DHH family; Region: DHH; pfam01368 471852007815 Ribosome-binding factor A; Region: RBFA; cl00542 471852007816 Protein of unknown function (DUF503); Region: DUF503; cl00669 471852007817 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471852007818 translation initiation factor IF-2; Region: IF-2; TIGR00487 471852007819 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471852007820 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 471852007821 G1 box; other site 471852007822 putative GEF interaction site [polypeptide binding]; other site 471852007823 GTP/Mg2+ binding site [chemical binding]; other site 471852007824 Switch I region; other site 471852007825 G2 box; other site 471852007826 G3 box; other site 471852007827 Switch II region; other site 471852007828 G4 box; other site 471852007829 G5 box; other site 471852007830 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 471852007831 Translation-initiation factor 2; Region: IF-2; pfam11987 471852007832 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 471852007833 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 471852007834 NusA N-terminal domain; Region: NusA_N; pfam08529 471852007835 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 471852007836 RNA binding site [nucleotide binding]; other site 471852007837 homodimer interface [polypeptide binding]; other site 471852007838 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 471852007839 G-X-X-G motif; other site 471852007840 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 471852007841 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471852007842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471852007843 motif II; other site 471852007844 Nitrate and nitrite sensing; Region: NIT; pfam08376 471852007845 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471852007846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852007847 ATP binding site [chemical binding]; other site 471852007848 Mg2+ binding site [ion binding]; other site 471852007849 G-X-G motif; other site 471852007850 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 471852007851 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471852007852 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852007853 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471852007854 Flavin Reductases; Region: FlaRed; cl00801 471852007855 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 471852007856 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 471852007857 FAD binding site [chemical binding]; other site 471852007858 substrate binding site [chemical binding]; other site 471852007859 catalytic base [active] 471852007860 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 471852007861 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383 471852007862 Active site [active] 471852007863 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383 471852007864 Active site [active] 471852007865 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 471852007866 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852007867 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852007868 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 471852007869 Peptidyl-tRNA hydrolase PTH2; Region: PTH2; pfam01981 471852007870 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471852007871 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471852007872 motif II; other site 471852007873 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 471852007874 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471852007875 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471852007876 catalytic residue [active] 471852007877 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852007878 transcriptional regulator BetI; Validated; Region: PRK00767 471852007879 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 471852007880 Stress responsive A/B Barrel Domain; Region: Dabb; cl06768 471852007881 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471852007882 Beta-lactamase; Region: Beta-lactamase; cl01009 471852007883 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 471852007884 Active_site [active] 471852007885 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471852007886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852007887 NAD(P) binding site [chemical binding]; other site 471852007888 active site 471852007889 amidase; Provisional; Region: PRK06061 471852007890 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 471852007891 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 471852007892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852007893 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 471852007894 potential catalytic triad [active] 471852007895 conserved cys residue [active] 471852007896 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471852007897 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852007898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471852007899 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852007900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471852007901 dimer interface [polypeptide binding]; other site 471852007902 phosphorylation site [posttranslational modification] 471852007903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852007904 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471852007905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852007906 active site 471852007907 phosphorylation site [posttranslational modification] 471852007908 intermolecular recognition site; other site 471852007909 dimerization interface [polypeptide binding]; other site 471852007910 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471852007911 DNA binding site [nucleotide binding] 471852007912 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471852007913 CoenzymeA binding site [chemical binding]; other site 471852007914 subunit interaction site [polypeptide binding]; other site 471852007915 PHB binding site; other site 471852007916 Putative cyclase; Region: Cyclase; cl00814 471852007917 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 471852007918 Predicted acetyltransferase [General function prediction only]; Region: COG3393 471852007919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852007920 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852007921 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 471852007922 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 471852007923 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 471852007924 active site 471852007925 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 471852007926 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 471852007927 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 471852007928 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471852007929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471852007930 Coenzyme A binding pocket [chemical binding]; other site 471852007931 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 471852007932 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471852007933 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 471852007934 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471852007935 tetrameric interface [polypeptide binding]; other site 471852007936 NAD binding site [chemical binding]; other site 471852007937 catalytic residues [active] 471852007938 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 471852007939 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 471852007940 inhibitor-cofactor binding pocket; inhibition site 471852007941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852007942 catalytic residue [active] 471852007943 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 471852007944 aromatic arch; other site 471852007945 DCoH dimer interaction site [polypeptide binding]; other site 471852007946 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 471852007947 DCoH tetramer interaction site [polypeptide binding]; other site 471852007948 substrate binding site [chemical binding]; other site 471852007949 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 471852007950 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471852007951 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471852007952 putative active site [active] 471852007953 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 471852007954 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 471852007955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852007956 NAD(P) binding site [chemical binding]; other site 471852007957 active site 471852007958 Predicted transcriptional regulator [Transcription]; Region: COG2378 471852007959 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 471852007960 Bacterial membrane flanked domain; Region: DUF304; cl01348 471852007961 Cytochrome P450; Region: p450; cl12078 471852007962 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852007963 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 471852007964 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 471852007965 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471852007966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852007967 dimer interface [polypeptide binding]; other site 471852007968 conserved gate region; other site 471852007969 putative PBP binding loops; other site 471852007970 ABC-ATPase subunit interface; other site 471852007971 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471852007972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852007973 dimer interface [polypeptide binding]; other site 471852007974 conserved gate region; other site 471852007975 putative PBP binding loops; other site 471852007976 ABC-ATPase subunit interface; other site 471852007977 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 471852007978 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471852007979 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 471852007980 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852007981 Walker A/P-loop; other site 471852007982 ATP binding site [chemical binding]; other site 471852007983 Q-loop/lid; other site 471852007984 ABC transporter signature motif; other site 471852007985 Walker B; other site 471852007986 D-loop; other site 471852007987 H-loop/switch region; other site 471852007988 TOBE domain; Region: TOBE_2; cl01440 471852007989 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471852007990 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 471852007991 tetrameric interface [polypeptide binding]; other site 471852007992 NAD binding site [chemical binding]; other site 471852007993 catalytic residues [active] 471852007994 substrate binding site [chemical binding]; other site 471852007995 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471852007996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852007997 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 471852007998 nucleotide binding site/active site [active] 471852007999 HIT family signature motif; other site 471852008000 catalytic residue [active] 471852008001 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 471852008002 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852008003 Walker A/P-loop; other site 471852008004 ATP binding site [chemical binding]; other site 471852008005 Q-loop/lid; other site 471852008006 ABC transporter signature motif; other site 471852008007 Walker B; other site 471852008008 D-loop; other site 471852008009 H-loop/switch region; other site 471852008010 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 471852008011 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 471852008012 DivIVA domain; Region: DivI1A_domain; TIGR03544 471852008013 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 471852008014 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 471852008015 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471852008016 FeS/SAM binding site; other site 471852008017 GTP cyclohydrolase; Provisional; Region: PRK08815 471852008018 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 471852008019 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 471852008020 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 471852008021 hinge region; other site 471852008022 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 471852008023 putative nucleotide binding site [chemical binding]; other site 471852008024 uridine monophosphate binding site [chemical binding]; other site 471852008025 homohexameric interface [polypeptide binding]; other site 471852008026 elongation factor Ts; Provisional; Region: tsf; PRK09377 471852008027 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 471852008028 Elongation factor TS; Region: EF_TS; pfam00889 471852008029 Elongation factor TS; Region: EF_TS; pfam00889 471852008030 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 471852008031 rRNA interaction site [nucleotide binding]; other site 471852008032 S8 interaction site; other site 471852008033 putative laminin-1 binding site; other site 471852008034 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 471852008035 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 471852008036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852008037 Walker A motif; other site 471852008038 ATP binding site [chemical binding]; other site 471852008039 Walker B motif; other site 471852008040 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 471852008041 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 471852008042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852008043 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 471852008044 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 471852008045 RNA/DNA hybrid binding site [nucleotide binding]; other site 471852008046 active site 471852008047 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 471852008048 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471852008049 Catalytic site [active] 471852008050 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 471852008051 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 471852008052 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 471852008053 RimM N-terminal domain; Region: RimM; pfam01782 471852008054 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 471852008055 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 471852008056 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 471852008057 signal recognition particle protein; Provisional; Region: PRK10867 471852008058 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 471852008059 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471852008060 P loop; other site 471852008061 GTP binding site [chemical binding]; other site 471852008062 Signal peptide binding domain; Region: SRP_SPB; pfam02978 471852008063 PII uridylyl-transferase; Provisional; Region: PRK03381 471852008064 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471852008065 metal binding triad; other site 471852008066 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471852008067 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471852008068 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 471852008069 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 471852008070 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 471852008071 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 471852008072 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 471852008073 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 471852008074 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852008075 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471852008076 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 471852008077 Walker A/P-loop; other site 471852008078 ATP binding site [chemical binding]; other site 471852008079 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 471852008080 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471852008081 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471852008082 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852008083 ABC transporter signature motif; other site 471852008084 Walker B; other site 471852008085 D-loop; other site 471852008086 H-loop/switch region; other site 471852008087 Acylphosphatase; Region: Acylphosphatase; cl00551 471852008088 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 471852008089 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 471852008090 DNA binding site [nucleotide binding] 471852008091 catalytic residue [active] 471852008092 H2TH interface [polypeptide binding]; other site 471852008093 putative catalytic residues [active] 471852008094 turnover-facilitating residue; other site 471852008095 intercalation triad [nucleotide binding]; other site 471852008096 8OG recognition residue [nucleotide binding]; other site 471852008097 putative reading head residues; other site 471852008098 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471852008099 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471852008100 ribonuclease III; Reviewed; Region: rnc; PRK00102 471852008101 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 471852008102 dimerization interface [polypeptide binding]; other site 471852008103 active site 471852008104 metal binding site [ion binding]; metal-binding site 471852008105 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 471852008106 dsRNA binding site [nucleotide binding]; other site 471852008107 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 471852008108 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 471852008109 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 471852008110 active site 471852008111 (T/H)XGH motif; other site 471852008112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852008113 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 471852008114 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 471852008115 generic binding surface II; other site 471852008116 ssDNA binding site; other site 471852008117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852008118 ATP binding site [chemical binding]; other site 471852008119 putative Mg++ binding site [ion binding]; other site 471852008120 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852008121 nucleotide binding region [chemical binding]; other site 471852008122 ATP-binding site [chemical binding]; other site 471852008123 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 471852008124 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 471852008125 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 471852008126 dimer interface [polypeptide binding]; other site 471852008127 substrate binding site [chemical binding]; other site 471852008128 ATP binding site [chemical binding]; other site 471852008129 Cellulose binding domain; Region: CBM_2; cl02709 471852008130 thiamine monophosphate kinase; Provisional; Region: PRK05731 471852008131 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 471852008132 ATP binding site [chemical binding]; other site 471852008133 dimerization interface [polypeptide binding]; other site 471852008134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852008135 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 471852008136 DinB superfamily; Region: DinB_2; cl00986 471852008137 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 471852008138 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471852008139 active site 471852008140 catalytic tetrad [active] 471852008141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852008142 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 471852008143 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 471852008144 heme-binding site [chemical binding]; other site 471852008145 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 471852008146 FAD binding pocket [chemical binding]; other site 471852008147 FAD binding motif [chemical binding]; other site 471852008148 phosphate binding motif [ion binding]; other site 471852008149 beta-alpha-beta structure motif; other site 471852008150 NAD binding pocket [chemical binding]; other site 471852008151 Heme binding pocket [chemical binding]; other site 471852008152 Predicted transcriptional regulator [Transcription]; Region: COG1959 471852008153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852008154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852008155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852008156 enoyl-CoA hydratase; Provisional; Region: PRK08259 471852008157 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852008158 substrate binding site [chemical binding]; other site 471852008159 oxyanion hole (OAH) forming residues; other site 471852008160 trimer interface [polypeptide binding]; other site 471852008161 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 471852008162 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 471852008163 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471852008164 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471852008165 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 471852008166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008167 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 471852008168 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471852008169 putative acyl-acceptor binding pocket; other site 471852008170 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471852008171 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 471852008172 IHF dimer interface [polypeptide binding]; other site 471852008173 IHF - DNA interface [nucleotide binding]; other site 471852008174 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 471852008175 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 471852008176 substrate binding site [chemical binding]; other site 471852008177 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 471852008178 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 471852008179 substrate binding site [chemical binding]; other site 471852008180 ligand binding site [chemical binding]; other site 471852008181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852008182 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471852008183 Bacterial transcriptional regulator; Region: IclR; pfam01614 471852008184 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471852008185 DNA binding residues [nucleotide binding] 471852008186 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 471852008187 nudix motif; other site 471852008188 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 471852008189 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 471852008190 active site 471852008191 metal binding site [ion binding]; metal-binding site 471852008192 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 471852008193 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 471852008194 active site 471852008195 catalytic residues [active] 471852008196 metal binding site [ion binding]; metal-binding site 471852008197 DmpG-like communication domain; Region: DmpG_comm; pfam07836 471852008198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008199 acetaldehyde dehydrogenase; Validated; Region: PRK08300 471852008200 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 471852008201 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471852008202 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 471852008203 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 471852008204 homodimer interface [polypeptide binding]; other site 471852008205 NAD binding site [chemical binding]; other site 471852008206 active site 471852008207 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 471852008208 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471852008209 dimer interface [polypeptide binding]; other site 471852008210 active site 471852008211 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852008212 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 471852008213 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471852008214 classical (c) SDRs; Region: SDR_c; cd05233 471852008215 NAD(P) binding site [chemical binding]; other site 471852008216 active site 471852008217 enoyl-CoA hydratase; Region: PLN02864 471852008218 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 471852008219 dimer interaction site [polypeptide binding]; other site 471852008220 substrate-binding tunnel; other site 471852008221 active site 471852008222 catalytic site [active] 471852008223 substrate binding site [chemical binding]; other site 471852008224 lipid-transfer protein; Provisional; Region: PRK07855 471852008225 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 471852008226 active site 471852008227 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 471852008228 putative active site [active] 471852008229 putative catalytic site [active] 471852008230 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471852008231 active site 471852008232 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 471852008233 active site 471852008234 catalytic site [active] 471852008235 DUF35 OB-fold domain; Region: DUF35; pfam01796 471852008236 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852008237 active site 471852008238 acyl-CoA synthetase; Provisional; Region: PRK13388 471852008239 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852008240 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 471852008241 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803 471852008242 active site 471852008243 FMN binding site [chemical binding]; other site 471852008244 substrate binding site [chemical binding]; other site 471852008245 putative catalytic residue [active] 471852008246 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 471852008247 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 471852008248 Walker A/P-loop; other site 471852008249 ATP binding site [chemical binding]; other site 471852008250 Q-loop/lid; other site 471852008251 ABC transporter signature motif; other site 471852008252 Walker B; other site 471852008253 D-loop; other site 471852008254 H-loop/switch region; other site 471852008255 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 471852008256 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 471852008257 Walker A/P-loop; other site 471852008258 ATP binding site [chemical binding]; other site 471852008259 Q-loop/lid; other site 471852008260 ABC transporter signature motif; other site 471852008261 Walker B; other site 471852008262 D-loop; other site 471852008263 H-loop/switch region; other site 471852008264 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 471852008265 TM-ABC transporter signature motif; other site 471852008266 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 471852008267 TM-ABC transporter signature motif; other site 471852008268 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471852008269 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 471852008270 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471852008271 classical (c) SDRs; Region: SDR_c; cd05233 471852008272 NAD(P) binding site [chemical binding]; other site 471852008273 active site 471852008274 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471852008275 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852008276 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471852008277 CoenzymeA binding site [chemical binding]; other site 471852008278 subunit interaction site [polypeptide binding]; other site 471852008279 PHB binding site; other site 471852008280 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852008281 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471852008282 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852008283 active site 471852008284 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852008285 active site 471852008286 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 471852008287 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471852008288 dimer interface [polypeptide binding]; other site 471852008289 active site 471852008290 acyl-CoA synthetase; Validated; Region: PRK07798 471852008291 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852008292 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852008293 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 471852008294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008295 NAD(P) binding site [chemical binding]; other site 471852008296 active site 471852008297 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471852008298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008299 NAD(P) binding site [chemical binding]; other site 471852008300 active site 471852008301 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471852008302 classical (c) SDRs; Region: SDR_c; cd05233 471852008303 NAD(P) binding site [chemical binding]; other site 471852008304 active site 471852008305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852008306 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852008307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008308 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 471852008309 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852008310 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 471852008311 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 471852008312 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852008313 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852008314 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 471852008315 Flavin binding site [chemical binding]; other site 471852008316 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 471852008317 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway...; Region: Rieske_RO_Alpha_KSH; cd03531 471852008318 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 471852008319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008320 NAD(P) binding site [chemical binding]; other site 471852008321 active site 471852008322 acyl-CoA synthetase; Provisional; Region: PRK13388 471852008323 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852008324 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 471852008325 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852008326 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 471852008327 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852008328 hypothetical protein; Validated; Region: PRK07121 471852008329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008330 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 471852008331 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 471852008332 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 471852008333 active site 471852008334 Fe binding site [ion binding]; other site 471852008335 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471852008336 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 471852008337 active site 471852008338 catalytic tetrad [active] 471852008339 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852008340 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852008341 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 471852008342 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-...; Region: PA_degradation_oxidoreductase_like; cd06214 471852008343 FAD binding pocket [chemical binding]; other site 471852008344 FAD binding motif [chemical binding]; other site 471852008345 phosphate binding motif [ion binding]; other site 471852008346 beta-alpha-beta structure motif; other site 471852008347 NAD(p) ribose binding residues [chemical binding]; other site 471852008348 NAD binding pocket [chemical binding]; other site 471852008349 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 471852008350 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471852008351 catalytic loop [active] 471852008352 iron binding site [ion binding]; other site 471852008353 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 471852008354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008355 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 471852008356 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852008357 Flavin Reductases; Region: FlaRed; cl00801 471852008358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852008359 Bacterial transcriptional regulator; Region: IclR; pfam01614 471852008360 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 471852008361 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852008362 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 471852008363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852008364 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471852008365 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471852008366 Ligand Binding Site [chemical binding]; other site 471852008367 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 471852008368 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 471852008369 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 471852008370 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 471852008371 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 471852008372 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471852008373 Ligand Binding Site [chemical binding]; other site 471852008374 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471852008375 Ligand Binding Site [chemical binding]; other site 471852008376 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 471852008377 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 471852008378 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 471852008379 putative molybdopterin cofactor binding site [chemical binding]; other site 471852008380 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787 471852008381 putative molybdopterin cofactor binding site; other site 471852008382 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 471852008383 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 471852008384 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471852008385 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471852008386 Cellulose binding domain; Region: CBM_2; cl02709 471852008387 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 471852008388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852008389 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 471852008390 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 471852008391 active site 471852008392 catalytic residues [active] 471852008393 metal binding site [ion binding]; metal-binding site 471852008394 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 471852008395 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 471852008396 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 471852008397 homodimer interface [polypeptide binding]; other site 471852008398 substrate-cofactor binding pocket; other site 471852008399 catalytic residue [active] 471852008400 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 471852008401 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 471852008402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008403 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 471852008404 putative L-serine binding site [chemical binding]; other site 471852008405 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471852008406 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471852008407 Walker A/P-loop; other site 471852008408 ATP binding site [chemical binding]; other site 471852008409 Q-loop/lid; other site 471852008410 ABC transporter signature motif; other site 471852008411 Walker B; other site 471852008412 D-loop; other site 471852008413 H-loop/switch region; other site 471852008414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852008415 ketol-acid reductoisomerase; Provisional; Region: PRK05479 471852008416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008417 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 471852008418 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 471852008419 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 471852008420 putative valine binding site [chemical binding]; other site 471852008421 dimer interface [polypeptide binding]; other site 471852008422 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 471852008423 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 471852008424 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471852008425 PYR/PP interface [polypeptide binding]; other site 471852008426 dimer interface [polypeptide binding]; other site 471852008427 TPP binding site [chemical binding]; other site 471852008428 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471852008429 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 471852008430 TPP-binding site [chemical binding]; other site 471852008431 dimer interface [polypeptide binding]; other site 471852008432 PAS domain S-box; Region: sensory_box; TIGR00229 471852008433 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471852008434 putative active site [active] 471852008435 heme pocket [chemical binding]; other site 471852008436 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471852008437 metal binding site [ion binding]; metal-binding site 471852008438 active site 471852008439 I-site; other site 471852008440 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471852008441 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 471852008442 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 471852008443 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 471852008444 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 471852008445 GatB domain; Region: GatB_Yqey; cl11497 471852008446 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471852008447 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 471852008448 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 471852008449 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471852008450 metal binding site [ion binding]; metal-binding site 471852008451 active site 471852008452 I-site; other site 471852008453 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471852008454 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 471852008455 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 471852008456 nucleotide binding pocket [chemical binding]; other site 471852008457 K-X-D-G motif; other site 471852008458 catalytic site [active] 471852008459 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 471852008460 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 471852008461 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 471852008462 Dimer interface [polypeptide binding]; other site 471852008463 BRCT sequence motif; other site 471852008464 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 471852008465 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step...; Region: CIMS_like; cd03310 471852008466 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 471852008467 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852008468 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 471852008469 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 471852008470 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471852008471 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 471852008472 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471852008473 catalytic residue [active] 471852008474 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 471852008475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852008476 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471852008477 Protein of unknown function DUF58; Region: DUF58; pfam01882 471852008478 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 471852008479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852008480 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 471852008481 Walker A motif; other site 471852008482 ATP binding site [chemical binding]; other site 471852008483 Walker B motif; other site 471852008484 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 471852008485 arginine finger; other site 471852008486 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 471852008487 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 471852008488 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 471852008489 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 471852008490 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 471852008491 Ligand binding site [chemical binding]; other site 471852008492 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852008493 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852008494 active site 471852008495 ATP binding site [chemical binding]; other site 471852008496 substrate binding site [chemical binding]; other site 471852008497 activation loop (A-loop); other site 471852008498 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852008499 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852008500 active site 471852008501 ATP binding site [chemical binding]; other site 471852008502 substrate binding site [chemical binding]; other site 471852008503 activation loop (A-loop); other site 471852008504 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 471852008505 homodimer interface [polypeptide binding]; other site 471852008506 putative substrate binding pocket [chemical binding]; other site 471852008507 diiron center [ion binding]; other site 471852008508 short chain dehydrogenase; Provisional; Region: PRK08219 471852008509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008510 NAD(P) binding site [chemical binding]; other site 471852008511 active site 471852008512 SNF2 Helicase protein; Region: DUF3670; pfam12419 471852008513 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 471852008514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852008515 ATP binding site [chemical binding]; other site 471852008516 putative Mg++ binding site [ion binding]; other site 471852008517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852008518 nucleotide binding region [chemical binding]; other site 471852008519 ATP-binding site [chemical binding]; other site 471852008520 Uncharacterized conserved protein [Function unknown]; Region: COG4279 471852008521 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 471852008522 putative homodimer interface [polypeptide binding]; other site 471852008523 putative active site pocket [active] 471852008524 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 471852008525 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 471852008526 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 471852008527 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 471852008528 trehalose synthase; Region: treS_nterm; TIGR02456 471852008529 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 471852008530 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 471852008531 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 471852008532 Ligand binding site [chemical binding]; other site 471852008533 Putative Catalytic site [active] 471852008534 DXD motif; other site 471852008535 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 471852008536 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 471852008537 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471852008538 active site 471852008539 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 471852008540 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471852008541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852008542 DNA-binding site [nucleotide binding]; DNA binding site 471852008543 UTRA domain; Region: UTRA; cl01230 471852008544 Cytochrome P450; Region: p450; cl12078 471852008545 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; cl10042 471852008546 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 471852008547 glycogen branching enzyme; Provisional; Region: PRK05402 471852008548 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 471852008549 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 471852008550 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 471852008551 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 471852008552 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 471852008553 nudix motif; other site 471852008554 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852008555 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852008556 active site 471852008557 ATP binding site [chemical binding]; other site 471852008558 substrate binding site [chemical binding]; other site 471852008559 activation loop (A-loop); other site 471852008560 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852008561 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852008562 active site 471852008563 ATP binding site [chemical binding]; other site 471852008564 substrate binding site [chemical binding]; other site 471852008565 activation loop (A-loop); other site 471852008566 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 471852008567 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471852008568 CoenzymeA binding site [chemical binding]; other site 471852008569 subunit interaction site [polypeptide binding]; other site 471852008570 PHB binding site; other site 471852008571 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 471852008572 tandem repeat interface [polypeptide binding]; other site 471852008573 oligomer interface [polypeptide binding]; other site 471852008574 active site residues [active] 471852008575 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 471852008576 oligomer interface [polypeptide binding]; other site 471852008577 tandem repeat interface [polypeptide binding]; other site 471852008578 active site residues [active] 471852008579 Flavin Reductases; Region: FlaRed; cl00801 471852008580 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852008581 active site 471852008582 ATP binding site [chemical binding]; other site 471852008583 substrate binding site [chemical binding]; other site 471852008584 activation loop (A-loop); other site 471852008585 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 471852008586 active site 471852008587 zinc binding site [ion binding]; other site 471852008588 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471852008589 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852008590 Walker A/P-loop; other site 471852008591 ATP binding site [chemical binding]; other site 471852008592 Q-loop/lid; other site 471852008593 ABC transporter signature motif; other site 471852008594 Walker B; other site 471852008595 D-loop; other site 471852008596 H-loop/switch region; other site 471852008597 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852008598 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471852008599 Walker A/P-loop; other site 471852008600 ATP binding site [chemical binding]; other site 471852008601 Q-loop/lid; other site 471852008602 ABC transporter signature motif; other site 471852008603 Walker B; other site 471852008604 D-loop; other site 471852008605 H-loop/switch region; other site 471852008606 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852008607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852008608 active site 471852008609 phosphorylation site [posttranslational modification] 471852008610 intermolecular recognition site; other site 471852008611 dimerization interface [polypeptide binding]; other site 471852008612 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852008613 DNA binding residues [nucleotide binding] 471852008614 dimerization interface [polypeptide binding]; other site 471852008615 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471852008616 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 471852008617 active site 471852008618 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 471852008619 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 471852008620 active site 471852008621 allantoate amidohydrolase; Reviewed; Region: PRK09290 471852008622 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 471852008623 active site 471852008624 metal binding site [ion binding]; metal-binding site 471852008625 dimer interface [polypeptide binding]; other site 471852008626 urocanate hydratase; Provisional; Region: PRK05414 471852008627 urocanate hydratase; Region: hutU; TIGR01228 471852008628 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 471852008629 active sites [active] 471852008630 tetramer interface [polypeptide binding]; other site 471852008631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852008632 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471852008633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852008634 Bacterial transcriptional regulator; Region: IclR; pfam01614 471852008635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852008636 S-adenosylmethionine binding site [chemical binding]; other site 471852008637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852008638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852008639 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 471852008640 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 471852008641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 471852008642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852008643 dimer interface [polypeptide binding]; other site 471852008644 conserved gate region; other site 471852008645 ABC-ATPase subunit interface; other site 471852008646 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471852008647 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 471852008648 Walker A/P-loop; other site 471852008649 ATP binding site [chemical binding]; other site 471852008650 Q-loop/lid; other site 471852008651 ABC transporter signature motif; other site 471852008652 Walker B; other site 471852008653 D-loop; other site 471852008654 H-loop/switch region; other site 471852008655 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471852008656 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471852008657 DNA binding site [nucleotide binding] 471852008658 domain linker motif; other site 471852008659 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471852008660 dimerization interface [polypeptide binding]; other site 471852008661 ligand binding site [chemical binding]; other site 471852008662 probable methyltransferase; Region: TIGR03438 471852008663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852008664 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 471852008665 TIGR03442 family protein; Region: TIGR03442 471852008666 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 471852008667 putative active site [active] 471852008668 putative dimer interface [polypeptide binding]; other site 471852008669 TIGR03440 family protein; Region: unchr_TIGR03440 471852008670 DinB superfamily; Region: DinB_2; cl00986 471852008671 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 471852008672 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 471852008673 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471852008674 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852008675 DNA binding residues [nucleotide binding] 471852008676 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852008677 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852008678 active site 471852008679 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852008680 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471852008681 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852008682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852008683 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 471852008684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008685 NAD(P) binding site [chemical binding]; other site 471852008686 active site 471852008687 Predicted transcriptional regulator [Transcription]; Region: COG2378 471852008688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852008689 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471852008690 putative active site [active] 471852008691 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 471852008692 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471852008693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008694 NAD(P) binding site [chemical binding]; other site 471852008695 active site 471852008696 Cytochrome P450; Region: p450; cl12078 471852008697 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471852008698 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471852008699 active site 471852008700 Cytochrome P450; Region: p450; cl12078 471852008701 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 471852008702 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471852008703 dimer interface [polypeptide binding]; other site 471852008704 active site 471852008705 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852008706 Cytochrome P450; Region: p450; cl12078 471852008707 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471852008708 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471852008709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852008710 S-adenosylmethionine binding site [chemical binding]; other site 471852008711 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 471852008712 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 471852008713 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 471852008714 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 471852008715 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 471852008716 generic binding surface II; other site 471852008717 generic binding surface I; other site 471852008718 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471852008719 putative catalytic site [active] 471852008720 putative metal binding site [ion binding]; other site 471852008721 putative phosphate binding site [ion binding]; other site 471852008722 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471852008723 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 471852008724 G1 box; other site 471852008725 GTP/Mg2+ binding site [chemical binding]; other site 471852008726 G2 box; other site 471852008727 Switch I region; other site 471852008728 G3 box; other site 471852008729 Switch II region; other site 471852008730 G4 box; other site 471852008731 G5 box; other site 471852008732 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471852008733 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 471852008734 Nitrate and nitrite sensing; Region: NIT; pfam08376 471852008735 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 471852008736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852008737 ATP binding site [chemical binding]; other site 471852008738 Mg2+ binding site [ion binding]; other site 471852008739 G-X-G motif; other site 471852008740 enoyl-CoA hydratase; Provisional; Region: PRK06688 471852008741 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852008742 substrate binding site [chemical binding]; other site 471852008743 oxyanion hole (OAH) forming residues; other site 471852008744 trimer interface [polypeptide binding]; other site 471852008745 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 471852008746 homodimer interface [polypeptide binding]; other site 471852008747 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471852008748 NAD binding site [chemical binding]; other site 471852008749 active site 471852008750 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 471852008751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008752 Protein of unknown function DUF124; Region: DUF124; cl00884 471852008753 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 471852008754 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 471852008755 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 471852008756 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 471852008757 TPP-binding site [chemical binding]; other site 471852008758 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 471852008759 Uncharacterized conserved protein [Function unknown]; Region: COG3595 471852008760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852008761 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471852008762 putative active site [active] 471852008763 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 471852008764 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471852008765 NAD(P) binding site [chemical binding]; other site 471852008766 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471852008767 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 471852008768 Walker A/P-loop; other site 471852008769 ATP binding site [chemical binding]; other site 471852008770 Q-loop/lid; other site 471852008771 ABC transporter signature motif; other site 471852008772 Walker B; other site 471852008773 D-loop; other site 471852008774 H-loop/switch region; other site 471852008775 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471852008776 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471852008777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852008778 dimer interface [polypeptide binding]; other site 471852008779 conserved gate region; other site 471852008780 putative PBP binding loops; other site 471852008781 ABC-ATPase subunit interface; other site 471852008782 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 471852008783 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471852008784 substrate binding pocket [chemical binding]; other site 471852008785 membrane-bound complex binding site; other site 471852008786 hinge residues; other site 471852008787 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 471852008788 Malic enzyme, N-terminal domain; Region: malic; pfam00390 471852008789 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 471852008790 putative NAD(P) binding site [chemical binding]; other site 471852008791 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 471852008792 CGNR zinc finger; Region: zf-CGNR; pfam11706 471852008793 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88)...; Region: Peptidase_S24_S26; cd06462 471852008794 Catalytic site [active] 471852008795 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 471852008796 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 471852008797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471852008798 Coenzyme A binding pocket [chemical binding]; other site 471852008799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852008800 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 471852008801 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852008802 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471852008803 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852008804 DNA binding residues [nucleotide binding] 471852008805 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471852008806 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471852008807 Transcription factor WhiB; Region: Whib; pfam02467 471852008808 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 471852008809 sensory histidine kinase DcuS; Provisional; Region: PRK11086 471852008810 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471852008811 Histidine kinase; Region: HisKA_2; cl06527 471852008812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852008813 ATP binding site [chemical binding]; other site 471852008814 Mg2+ binding site [ion binding]; other site 471852008815 G-X-G motif; other site 471852008816 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 471852008817 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471852008818 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471852008819 catalytic residue [active] 471852008820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852008821 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 471852008822 DNA-binding site [nucleotide binding]; DNA binding site 471852008823 UTRA domain; Region: UTRA; cl01230 471852008824 biotin synthase; Validated; Region: PRK06256 471852008825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471852008826 FeS/SAM binding site; other site 471852008827 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 471852008828 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852008829 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852008830 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 471852008831 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 471852008832 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 471852008833 carboxyltransferase (CT) interaction site; other site 471852008834 biotinylation site [posttranslational modification]; other site 471852008835 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 471852008836 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471852008837 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471852008838 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 471852008839 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 471852008840 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471852008841 Zn2+ binding site [ion binding]; other site 471852008842 Mg2+ binding site [ion binding]; other site 471852008843 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471852008844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008845 NAD(P) binding site [chemical binding]; other site 471852008846 active site 471852008847 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 471852008848 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 471852008849 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852008850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852008851 DNA binding residues [nucleotide binding] 471852008852 Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521 471852008853 hypothetical protein; Provisional; Region: PRK08317 471852008854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852008855 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 471852008856 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 471852008857 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 471852008858 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 471852008859 hinge; other site 471852008860 active site 471852008861 Predicted GTPases [General function prediction only]; Region: COG1162 471852008862 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 471852008863 GTPase/OB domain interface [polypeptide binding]; other site 471852008864 GTPase/Zn-binding domain interface [polypeptide binding]; other site 471852008865 GTP/Mg2+ binding site [chemical binding]; other site 471852008866 G4 box; other site 471852008867 G5 box; other site 471852008868 G1 box; other site 471852008869 Switch I region; other site 471852008870 G2 box; other site 471852008871 G3 box; other site 471852008872 Switch II region; other site 471852008873 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 471852008874 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 471852008875 cofactor binding site; other site 471852008876 metal binding site [ion binding]; metal-binding site 471852008877 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 471852008878 active site 471852008879 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 471852008880 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471852008881 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 471852008882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852008883 short chain dehydrogenase; Provisional; Region: PRK07825 471852008884 classical (c) SDRs; Region: SDR_c; cd05233 471852008885 NAD(P) binding site [chemical binding]; other site 471852008886 active site 471852008887 Cytochrome P450; Region: p450; cl12078 471852008888 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 471852008889 AMP-binding enzyme; Region: AMP-binding; pfam00501 471852008890 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852008891 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 471852008892 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 471852008893 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117 471852008894 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 471852008895 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 471852008896 MoaE homodimer interface [polypeptide binding]; other site 471852008897 MoaD interaction [polypeptide binding]; other site 471852008898 active site residues [active] 471852008899 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 471852008900 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 471852008901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008902 NAD(P) binding site [chemical binding]; other site 471852008903 active site 471852008904 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 471852008905 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 471852008906 nudix motif; other site 471852008907 Protein of unknown function DUF45; Region: DUF45; cl00636 471852008908 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 471852008909 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852008910 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852008911 Transcription factor WhiB; Region: Whib; pfam02467 471852008912 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 471852008913 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 471852008914 active site 471852008915 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 471852008916 catalytic triad [active] 471852008917 dimer interface [polypeptide binding]; other site 471852008918 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471852008919 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471852008920 HRDC domain; Region: HRDC; cl02578 471852008921 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 471852008922 catalytic residues [active] 471852008923 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 471852008924 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 471852008925 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 471852008926 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 471852008927 putative NADH binding site [chemical binding]; other site 471852008928 putative active site [active] 471852008929 nudix motif; other site 471852008930 putative metal binding site [ion binding]; other site 471852008931 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471852008932 argininosuccinate lyase; Provisional; Region: PRK02186 471852008933 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471852008934 IucA / IucC family; Region: IucA_IucC; pfam04183 471852008935 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 471852008936 IucA / IucC family; Region: IucA_IucC; pfam04183 471852008937 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 471852008938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852008939 S-adenosylmethionine binding site [chemical binding]; other site 471852008940 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471852008941 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471852008942 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 471852008943 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471852008944 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471852008945 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471852008946 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471852008947 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471852008948 DNA binding site [nucleotide binding] 471852008949 active site 471852008950 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471852008951 active site 471852008952 catalytic residues [active] 471852008953 CsbD-like; Region: CsbD; cl01272 471852008954 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 471852008955 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 471852008956 ATP binding site [chemical binding]; other site 471852008957 substrate interface [chemical binding]; other site 471852008958 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471852008959 active site residue [active] 471852008960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852008961 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852008962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852008963 S-adenosylmethionine binding site [chemical binding]; other site 471852008964 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852008965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852008966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852008967 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471852008968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852008969 NAD(P) binding site [chemical binding]; other site 471852008970 active site 471852008971 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852008972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852008973 Cytochrome P450; Region: p450; cl12078 471852008974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852008975 S-adenosylmethionine binding site [chemical binding]; other site 471852008976 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852008977 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852008978 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852008979 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852008980 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852008981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471852008982 non-specific DNA binding site [nucleotide binding]; other site 471852008983 salt bridge; other site 471852008984 sequence-specific DNA binding site [nucleotide binding]; other site 471852008985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852008986 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852008987 prolyl-tRNA synthetase; Provisional; Region: PRK09194 471852008988 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471852008989 motif 1; other site 471852008990 dimer interface [polypeptide binding]; other site 471852008991 active site 471852008992 motif 2; other site 471852008993 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 471852008994 putative deacylase active site [active] 471852008995 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471852008996 active site 471852008997 motif 3; other site 471852008998 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 471852008999 anticodon binding site; other site 471852009000 FOG: CBS domain [General function prediction only]; Region: COG0517 471852009001 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622 471852009002 RNA polymerase factor sigma-70; Validated; Region: PRK08241 471852009003 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852009004 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852009005 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471852009006 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 471852009007 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471852009008 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 471852009009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852009010 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 471852009011 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852009012 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 471852009013 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 471852009014 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 471852009015 putative metal binding site [ion binding]; other site 471852009016 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852009017 Leucine carboxyl methyltransferase; Region: LCM; cl01306 471852009018 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852009019 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471852009020 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471852009021 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 471852009022 Nitrate and nitrite sensing; Region: NIT; pfam08376 471852009023 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852009024 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 471852009025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852009026 ATP binding site [chemical binding]; other site 471852009027 Mg2+ binding site [ion binding]; other site 471852009028 G-X-G motif; other site 471852009029 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 471852009030 substrate binding pocket [chemical binding]; other site 471852009031 substrate-Mg2+ binding site; other site 471852009032 aspartate-rich region 1; other site 471852009033 aspartate-rich region 2; other site 471852009034 Cytochrome P450; Region: p450; cl12078 471852009035 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 471852009036 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 471852009037 Protein of unknown function (DUF742); Region: DUF742; pfam05331 471852009038 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852009039 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 471852009040 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471852009041 Ligand Binding Site [chemical binding]; other site 471852009042 Amidinotransferase; Region: Amidinotransf; cl12043 471852009043 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 471852009044 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 471852009045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852009046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852009047 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471852009048 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 471852009049 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 471852009050 Condensation domain; Region: Condensation; cl09290 471852009051 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 471852009052 ligand binding site [chemical binding]; other site 471852009053 active site 471852009054 UGI interface [polypeptide binding]; other site 471852009055 catalytic site [active] 471852009056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852009057 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471852009058 Walker A motif; other site 471852009059 ATP binding site [chemical binding]; other site 471852009060 Walker B motif; other site 471852009061 arginine finger; other site 471852009062 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 471852009063 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471852009064 homodimer interface [polypeptide binding]; other site 471852009065 substrate-cofactor binding pocket; other site 471852009066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852009067 catalytic residue [active] 471852009068 mce related protein; Region: MCE; pfam02470 471852009069 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471852009070 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471852009071 mce related protein; Region: MCE; pfam02470 471852009072 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471852009073 mce related protein; Region: MCE; pfam02470 471852009074 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 471852009075 mce related protein; Region: MCE; pfam02470 471852009076 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471852009077 mce related protein; Region: MCE; pfam02470 471852009078 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471852009079 mce related protein; Region: MCE; pfam02470 471852009080 Domain of unknown function DUF140; Region: DUF140; cl00510 471852009081 Domain of unknown function DUF140; Region: DUF140; cl00510 471852009082 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471852009083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852009084 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 471852009085 catalytic residue [active] 471852009086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852009087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852009088 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852009089 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 471852009090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852009091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852009092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852009093 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 471852009094 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 471852009095 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 471852009096 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852009097 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 471852009098 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 471852009099 active site 471852009100 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 471852009101 protein binding site [polypeptide binding]; other site 471852009102 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471852009103 putative substrate binding region [chemical binding]; other site 471852009104 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471852009105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852009106 DNA-binding site [nucleotide binding]; DNA binding site 471852009107 FCD domain; Region: FCD; cl11656 471852009108 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 471852009109 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 471852009110 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471852009111 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 471852009112 lipoyl attachment site [posttranslational modification]; other site 471852009113 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 471852009114 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 471852009115 dimer interface [polypeptide binding]; other site 471852009116 glycine-pyridoxal phosphate binding site [chemical binding]; other site 471852009117 active site 471852009118 folate binding site [chemical binding]; other site 471852009119 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 471852009120 DinB superfamily; Region: DinB_2; cl00986 471852009121 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 471852009122 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 471852009123 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 471852009124 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 471852009125 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 471852009126 putative active site [active] 471852009127 putative substrate binding site [chemical binding]; other site 471852009128 putative cosubstrate binding site; other site 471852009129 catalytic site [active] 471852009130 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 471852009131 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852009132 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 471852009133 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 471852009134 dimer interface [polypeptide binding]; other site 471852009135 active site 471852009136 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471852009137 substrate binding site [chemical binding]; other site 471852009138 catalytic residue [active] 471852009139 Protein of unknown function (DUF541); Region: SIMPL; cl01077 471852009140 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 471852009141 substrate binding site [chemical binding]; other site 471852009142 ATP binding site [chemical binding]; other site 471852009143 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 471852009144 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 471852009145 NAD(P) binding site [chemical binding]; other site 471852009146 LDH/MDH dimer interface [polypeptide binding]; other site 471852009147 substrate binding site [chemical binding]; other site 471852009148 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 471852009149 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 471852009150 catalytic triad [active] 471852009151 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471852009152 anti sigma factor interaction site; other site 471852009153 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 471852009154 active site 471852009155 dimerization interface [polypeptide binding]; other site 471852009156 ribonuclease PH; Reviewed; Region: rph; PRK00173 471852009157 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 471852009158 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852009159 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 471852009160 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471852009161 active site 2 [active] 471852009162 active site 1 [active] 471852009163 Domain of unknown function (DUF3825); Region: DUF3825; pfam12873 471852009164 cysteine synthases; Region: cysKM; TIGR01136 471852009165 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 471852009166 dimer interface [polypeptide binding]; other site 471852009167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852009168 catalytic residue [active] 471852009169 Ubiquitin-like proteins; Region: UBQ; cl00155 471852009170 charged pocket; other site 471852009171 hydrophobic patch; other site 471852009172 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 471852009173 MPN+ (JAMM) motif; other site 471852009174 Zinc-binding site [ion binding]; other site 471852009175 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 471852009176 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 471852009177 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 471852009178 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 471852009179 active site 471852009180 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 471852009181 Isochorismatase family; Region: Isochorismatase; pfam00857 471852009182 catalytic triad [active] 471852009183 metal binding site [ion binding]; metal-binding site 471852009184 conserved cis-peptide bond; other site 471852009185 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 471852009186 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 471852009187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852009188 ATP binding site [chemical binding]; other site 471852009189 putative Mg++ binding site [ion binding]; other site 471852009190 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor...; Region: ZnMc_pappalysin_like; cd04275 471852009191 active site 471852009192 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 471852009193 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 471852009194 Malic enzyme, N-terminal domain; Region: malic; pfam00390 471852009195 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 471852009196 putative NAD(P) binding site [chemical binding]; other site 471852009197 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 471852009198 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 471852009199 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852009200 Walker A/P-loop; other site 471852009201 ATP binding site [chemical binding]; other site 471852009202 Q-loop/lid; other site 471852009203 ABC transporter signature motif; other site 471852009204 Walker B; other site 471852009205 D-loop; other site 471852009206 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 471852009207 putative acyltransferase; Provisional; Region: PRK05790 471852009208 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471852009209 dimer interface [polypeptide binding]; other site 471852009210 active site 471852009211 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 471852009212 dimer interface [polypeptide binding]; other site 471852009213 substrate binding site [chemical binding]; other site 471852009214 metal binding site [ion binding]; metal-binding site 471852009215 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471852009216 ligand binding site [chemical binding]; other site 471852009217 DivIVA protein; Region: DivIVA; pfam05103 471852009218 Domain of unknown function DUF20; Region: UPF0118; cl00465 471852009219 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 471852009220 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852009221 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852009222 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 471852009223 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 471852009224 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471852009225 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471852009226 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 471852009227 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471852009228 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471852009229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852009230 Protein of unknown function DUF91; Region: DUF91; cl00709 471852009231 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 471852009232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852009233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852009234 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 471852009235 active site 471852009236 putative substrate binding region [chemical binding]; other site 471852009237 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 471852009238 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 471852009239 substrate binding site [chemical binding]; other site 471852009240 amidase catalytic site [active] 471852009241 Zn binding residues [ion binding]; other site 471852009242 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471852009243 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 471852009244 NAD(P) binding site [chemical binding]; other site 471852009245 catalytic residues [active] 471852009246 choline dehydrogenase; Validated; Region: PRK02106 471852009247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852009248 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471852009249 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 471852009250 Uncharacterized conserved protein [Function unknown]; Region: COG3595 471852009251 M28, and M42; Region: Zinc_peptidase_like; cl14876 471852009252 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain...; Region: PA; cl08238 471852009253 PA/protease or protease-like domain interface [polypeptide binding]; other site 471852009254 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 471852009255 active site 471852009256 metal binding site [ion binding]; metal-binding site 471852009257 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 471852009258 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 471852009259 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 471852009260 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 471852009261 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 471852009262 alpha subunit interaction interface [polypeptide binding]; other site 471852009263 Walker A motif; other site 471852009264 ATP binding site [chemical binding]; other site 471852009265 Walker B motif; other site 471852009266 inhibitor binding site; inhibition site 471852009267 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471852009268 ATP synthase; Region: ATP-synt; cl00365 471852009269 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 471852009270 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 471852009271 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 471852009272 beta subunit interaction interface [polypeptide binding]; other site 471852009273 Walker A motif; other site 471852009274 ATP binding site [chemical binding]; other site 471852009275 Walker B motif; other site 471852009276 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471852009277 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 471852009278 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 471852009279 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 471852009280 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 471852009281 ATP synthase subunit C; Region: ATP-synt_C; cl00466 471852009282 ATP synthase A chain; Region: ATP-synt_A; cl00413 471852009283 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 471852009284 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 471852009285 Mg++ binding site [ion binding]; other site 471852009286 putative catalytic motif [active] 471852009287 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 471852009288 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 471852009289 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 471852009290 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 471852009291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852009292 S-adenosylmethionine binding site [chemical binding]; other site 471852009293 peptide chain release factor 1; Validated; Region: prfA; PRK00591 471852009294 RF-1 domain; Region: RF-1; cl02875 471852009295 RF-1 domain; Region: RF-1; cl02875 471852009296 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 471852009297 transcriptional regulator NarP; Provisional; Region: PRK10403 471852009298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852009299 active site 471852009300 phosphorylation site [posttranslational modification] 471852009301 intermolecular recognition site; other site 471852009302 dimerization interface [polypeptide binding]; other site 471852009303 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852009304 DNA binding residues [nucleotide binding] 471852009305 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471852009306 Histidine kinase; Region: HisKA_3; pfam07730 471852009307 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 471852009308 transcription termination factor Rho; Provisional; Region: PRK12608 471852009309 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 471852009310 RNA binding site [nucleotide binding]; other site 471852009311 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 471852009312 multimer interface [polypeptide binding]; other site 471852009313 Walker A motif; other site 471852009314 ATP binding site [chemical binding]; other site 471852009315 Walker B motif; other site 471852009316 homoserine kinase; Provisional; Region: PRK01212 471852009317 threonine synthase; Reviewed; Region: PRK06721 471852009318 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 471852009319 homodimer interface [polypeptide binding]; other site 471852009320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852009321 catalytic residue [active] 471852009322 homoserine dehydrogenase; Provisional; Region: PRK06349 471852009323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852009324 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 471852009325 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 471852009326 diaminopimelate decarboxylase; Region: lysA; TIGR01048 471852009327 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 471852009328 active site 471852009329 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471852009330 substrate binding site [chemical binding]; other site 471852009331 catalytic residues [active] 471852009332 dimer interface [polypeptide binding]; other site 471852009333 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 471852009334 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471852009335 Response regulator receiver domain; Region: Response_reg; pfam00072 471852009336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852009337 active site 471852009338 phosphorylation site [posttranslational modification] 471852009339 intermolecular recognition site; other site 471852009340 dimerization interface [polypeptide binding]; other site 471852009341 Phage integrase family; Region: Phage_integrase; pfam00589 471852009342 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 471852009343 DNA binding site [nucleotide binding] 471852009344 Int/Topo IB signature motif; other site 471852009345 active site 471852009346 catalytic residues [active] 471852009347 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471852009348 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471852009349 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 471852009350 active site 471852009351 hypothetical protein; Provisional; Region: PRK11239 471852009352 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471852009353 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471852009354 catalytic core [active] 471852009355 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 471852009356 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803 471852009357 active site 471852009358 FMN binding site [chemical binding]; other site 471852009359 substrate binding site [chemical binding]; other site 471852009360 putative catalytic residue [active] 471852009361 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 471852009362 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471852009363 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 471852009364 classical (c) SDRs; Region: SDR_c; cd05233 471852009365 NAD(P) binding site [chemical binding]; other site 471852009366 active site 471852009367 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 471852009368 arginine-tRNA ligase; Region: PLN02286 471852009369 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 471852009370 active site 471852009371 HIGH motif; other site 471852009372 KMSK motif region; other site 471852009373 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 471852009374 tRNA binding surface [nucleotide binding]; other site 471852009375 anticodon binding site; other site 471852009376 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 471852009377 Protein of unknown function DUF82; Region: DUF82; pfam01927 471852009378 Cytochrome P450; Region: p450; cl12078 471852009379 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 471852009380 Beta-lactamase; Region: Beta-lactamase; cl01009 471852009381 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 471852009382 L-tyrosine decarboxylase; Provisional; Region: PRK13520 471852009383 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471852009384 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471852009385 catalytic residue [active] 471852009386 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 471852009387 putative transporter; Provisional; Region: PRK11462 471852009388 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471852009389 LysE type translocator; Region: LysE; cl00565 471852009390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852009391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852009392 thiamine pyrophosphate protein; Provisional; Region: PRK08273 471852009393 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 471852009394 PYR/PP interface [polypeptide binding]; other site 471852009395 tetramer interface [polypeptide binding]; other site 471852009396 dimer interface [polypeptide binding]; other site 471852009397 TPP binding site [chemical binding]; other site 471852009398 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471852009399 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 471852009400 TPP-binding site [chemical binding]; other site 471852009401 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852009402 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852009403 active site 471852009404 ATP binding site [chemical binding]; other site 471852009405 substrate binding site [chemical binding]; other site 471852009406 activation loop (A-loop); other site 471852009407 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852009408 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852009409 active site 471852009410 ATP binding site [chemical binding]; other site 471852009411 substrate binding site [chemical binding]; other site 471852009412 activation loop (A-loop); other site 471852009413 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852009414 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852009415 active site 471852009416 ATP binding site [chemical binding]; other site 471852009417 substrate binding site [chemical binding]; other site 471852009418 activation loop (A-loop); other site 471852009419 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 471852009420 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 471852009421 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 471852009422 dimer interface [polypeptide binding]; other site 471852009423 putative anticodon binding site; other site 471852009424 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471852009425 motif 1; other site 471852009426 dimer interface [polypeptide binding]; other site 471852009427 active site 471852009428 motif 2; other site 471852009429 motif 3; other site 471852009430 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471852009431 active site 471852009432 metal binding site [ion binding]; metal-binding site 471852009433 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471852009434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471852009435 motif II; other site 471852009436 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852009437 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 471852009438 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 471852009439 putative active site [active] 471852009440 putative substrate binding site [chemical binding]; other site 471852009441 ATP binding site [chemical binding]; other site 471852009442 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 471852009443 coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024 471852009444 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471852009445 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471852009446 classical (c) SDRs; Region: SDR_c; cd05233 471852009447 NAD(P) binding site [chemical binding]; other site 471852009448 active site 471852009449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852009450 acyl-CoA synthetase; Validated; Region: PRK07798 471852009451 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852009452 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852009453 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 471852009454 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 471852009455 active site 471852009456 lipid-transfer protein; Provisional; Region: PRK07937 471852009457 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 471852009458 active site 471852009459 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 471852009460 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 471852009461 DUF35 OB-fold domain; Region: DUF35; pfam01796 471852009462 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 471852009463 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852009464 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852009465 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852009466 enoyl-CoA hydratase; Provisional; Region: PRK07799 471852009467 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852009468 substrate binding site [chemical binding]; other site 471852009469 oxyanion hole (OAH) forming residues; other site 471852009470 trimer interface [polypeptide binding]; other site 471852009471 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 471852009472 Nitronate monooxygenase; Region: NMO; pfam03060 471852009473 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 471852009474 FMN binding site [chemical binding]; other site 471852009475 substrate binding site [chemical binding]; other site 471852009476 putative catalytic residue [active] 471852009477 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 471852009478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852009479 S-adenosylmethionine binding site [chemical binding]; other site 471852009480 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471852009481 FG-GAP repeat; Region: FG-GAP; cl15299 471852009482 FG-GAP repeat; Region: FG-GAP; cl15299 471852009483 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 471852009484 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 471852009485 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471852009486 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471852009487 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471852009488 active site 471852009489 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852009490 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471852009491 substrate binding pocket [chemical binding]; other site 471852009492 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852009493 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852009494 active site 471852009495 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852009496 active site 471852009497 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 471852009498 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852009499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852009500 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 471852009501 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471852009502 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 471852009503 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 471852009504 SmpB-tmRNA interface; other site 471852009505 C-terminal peptidase (prc); Region: prc; TIGR00225 471852009506 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 471852009507 protein binding site [polypeptide binding]; other site 471852009508 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 471852009509 Catalytic dyad [active] 471852009510 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 471852009511 FtsX-like permease family; Region: FtsX; pfam02687 471852009512 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 471852009513 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852009514 Walker A/P-loop; other site 471852009515 ATP binding site [chemical binding]; other site 471852009516 Q-loop/lid; other site 471852009517 ABC transporter signature motif; other site 471852009518 Walker B; other site 471852009519 D-loop; other site 471852009520 H-loop/switch region; other site 471852009521 peptide chain release factor 2; Validated; Region: prfB; PRK00578 471852009522 RF-1 domain; Region: RF-1; cl02875 471852009523 RF-1 domain; Region: RF-1; cl02875 471852009524 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 471852009525 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 471852009526 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852009527 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852009528 active site 471852009529 ATP binding site [chemical binding]; other site 471852009530 substrate binding site [chemical binding]; other site 471852009531 activation loop (A-loop); other site 471852009532 NlpC/P60 family; Region: NLPC_P60; cl11438 471852009533 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 471852009534 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852009535 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 471852009536 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471852009537 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471852009538 NAD(P) binding site [chemical binding]; other site 471852009539 catalytic residues [active] 471852009540 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471852009541 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 471852009542 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852009543 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 471852009544 FAD binding site [chemical binding]; other site 471852009545 substrate binding site [chemical binding]; other site 471852009546 catalytic base [active] 471852009547 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 471852009548 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 471852009549 putative active site [active] 471852009550 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471852009551 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 471852009552 putative active site [active] 471852009553 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 471852009554 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471852009555 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471852009556 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471852009557 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 471852009558 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 471852009559 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 471852009560 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 471852009561 dimerization domain swap beta strand [polypeptide binding]; other site 471852009562 regulatory protein interface [polypeptide binding]; other site 471852009563 active site 471852009564 regulatory phosphorylation site [posttranslational modification]; other site 471852009565 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 471852009566 HPr interaction site; other site 471852009567 glycerol kinase (GK) interaction site [polypeptide binding]; other site 471852009568 active site 471852009569 phosphorylation site [posttranslational modification] 471852009570 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 471852009571 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cl00164 471852009572 active site turn [active] 471852009573 phosphorylation site [posttranslational modification] 471852009574 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 471852009575 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471852009576 dimer interface [polypeptide binding]; other site 471852009577 active site 471852009578 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471852009579 dimer interface [polypeptide binding]; other site 471852009580 active site 471852009581 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 471852009582 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 471852009583 active site 471852009584 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471852009585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852009586 DNA-binding site [nucleotide binding]; DNA binding site 471852009587 UTRA domain; Region: UTRA; cl01230 471852009588 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 471852009589 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 471852009590 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852009591 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 471852009592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852009593 nucleotide binding region [chemical binding]; other site 471852009594 ATP-binding site [chemical binding]; other site 471852009595 SEC-C motif; Region: SEC-C; cl12132 471852009596 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 471852009597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 471852009598 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852009599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852009600 active site 471852009601 phosphorylation site [posttranslational modification] 471852009602 intermolecular recognition site; other site 471852009603 dimerization interface [polypeptide binding]; other site 471852009604 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852009605 DNA binding residues [nucleotide binding] 471852009606 dimerization interface [polypeptide binding]; other site 471852009607 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 471852009608 30S subunit binding site; other site 471852009609 lipoprotein LpqB; Provisional; Region: PRK13613 471852009610 Sporulation and spore germination; Region: Germane; cl11253 471852009611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471852009612 dimer interface [polypeptide binding]; other site 471852009613 phosphorylation site [posttranslational modification] 471852009614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852009615 ATP binding site [chemical binding]; other site 471852009616 Mg2+ binding site [ion binding]; other site 471852009617 G-X-G motif; other site 471852009618 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471852009619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852009620 active site 471852009621 phosphorylation site [posttranslational modification] 471852009622 intermolecular recognition site; other site 471852009623 dimerization interface [polypeptide binding]; other site 471852009624 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471852009625 DNA binding site [nucleotide binding] 471852009626 MoxR-like ATPases [General function prediction only]; Region: COG0714 471852009627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852009628 Walker A motif; other site 471852009629 ATP binding site [chemical binding]; other site 471852009630 Walker B motif; other site 471852009631 arginine finger; other site 471852009632 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471852009633 Protein of unknown function DUF58; Region: DUF58; pfam01882 471852009634 Integral membrane protein DUF95; Region: DUF95; cl00572 471852009635 RDD family; Region: RDD; cl00746 471852009636 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 471852009637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852009638 oligomerization interface [polypeptide binding]; other site 471852009639 active site 471852009640 NAD+ binding site [chemical binding]; other site 471852009641 Adenosylhomocysteinase; Provisional; Region: PTZ00075 471852009642 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401 471852009643 oligomerization interface [polypeptide binding]; other site 471852009644 active site 471852009645 NAD+ binding site [chemical binding]; other site 471852009646 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471852009647 DNA binding residues [nucleotide binding] 471852009648 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 471852009649 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 471852009650 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471852009651 Ligand Binding Site [chemical binding]; other site 471852009652 Cation efflux family; Region: Cation_efflux; cl00316 471852009653 bifunctional phosphoglucose/phosphomannose isomerase; Region: G6PI_arch; TIGR02128 471852009654 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 471852009655 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 471852009656 dimer interface [polypeptide binding]; other site 471852009657 active site 471852009658 Trm112p-like protein; Region: Trm112p; cl01066 471852009659 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 471852009660 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 471852009661 active site 471852009662 substrate binding site [chemical binding]; other site 471852009663 metal binding site [ion binding]; metal-binding site 471852009664 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 471852009665 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 471852009666 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471852009667 active site 471852009668 Transcription factor WhiB; Region: Whib; pfam02467 471852009669 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 471852009670 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 471852009671 phosphate binding site [ion binding]; other site 471852009672 dimer interface [polypeptide binding]; other site 471852009673 substrate binding site [chemical binding]; other site 471852009674 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 471852009675 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 471852009676 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes...; Region: NADPH_oxidoreductase_1; cd02150 471852009677 putative FMN binding site [chemical binding]; other site 471852009678 FO synthase; Reviewed; Region: fbiC; PRK09234 471852009679 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471852009680 FeS/SAM binding site; other site 471852009681 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 471852009682 FeS/SAM binding site; other site 471852009683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852009684 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 471852009685 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 471852009686 putative dimerization interface [polypeptide binding]; other site 471852009687 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 471852009688 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471852009689 minor groove reading motif; other site 471852009690 helix-hairpin-helix signature motif; other site 471852009691 active site 471852009692 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 471852009693 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 471852009694 active site 471852009695 Substrate binding site [chemical binding]; other site 471852009696 Mg++ binding site [ion binding]; other site 471852009697 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 471852009698 tocopherol O-methyltransferase; Region: PLN02244 471852009699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852009700 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 471852009701 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471852009702 catalytic residues [active] 471852009703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471852009704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852009705 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852009706 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852009707 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471852009708 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471852009709 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 471852009710 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 471852009711 Ligand binding site [chemical binding]; other site 471852009712 Putative Catalytic site [active] 471852009713 DXD motif; other site 471852009714 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852009715 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 471852009716 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471852009717 Acyltransferase family; Region: Acyl_transf_3; pfam01757 471852009718 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 471852009719 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471852009720 active site 471852009721 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 471852009722 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471852009723 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471852009724 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 471852009725 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 471852009726 hydrophobic ligand binding site; other site 471852009727 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 471852009728 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471852009729 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471852009730 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471852009731 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471852009732 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471852009733 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 471852009734 Probable Catalytic site [active] 471852009735 metal binding site [ion binding]; metal-binding site 471852009736 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471852009737 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 471852009738 active site 471852009739 NAD binding site [chemical binding]; other site 471852009740 metal binding site [ion binding]; metal-binding site 471852009741 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 471852009742 active site 471852009743 metal binding site [ion binding]; metal-binding site 471852009744 potential frameshift: common BLAST hit: gi|159036188|ref|YP_001535441.1| CDP-alcohol phosphatidyltransferase 471852009745 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471852009746 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471852009747 substrate binding site [chemical binding]; other site 471852009748 dimer interface [polypeptide binding]; other site 471852009749 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 471852009750 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 471852009751 active site 471852009752 catalytic site [active] 471852009753 metal binding site [ion binding]; metal-binding site 471852009754 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 471852009755 Ligand binding site [chemical binding]; other site 471852009756 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471852009757 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852009758 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 471852009759 FAD binding site [chemical binding]; other site 471852009760 homotetramer interface [polypeptide binding]; other site 471852009761 substrate binding pocket [chemical binding]; other site 471852009762 catalytic base [active] 471852009763 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852009764 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852009765 active site 471852009766 ATP binding site [chemical binding]; other site 471852009767 substrate binding site [chemical binding]; other site 471852009768 activation loop (A-loop); other site 471852009769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852009770 AIR carboxylase; Region: AIRC; cl00310 471852009771 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 471852009772 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471852009773 GtrA-like protein; Region: GtrA; cl00971 471852009774 sensor protein BasS/PmrB; Provisional; Region: PRK10755 471852009775 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471852009776 dimer interface [polypeptide binding]; other site 471852009777 phosphorylation site [posttranslational modification] 471852009778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852009779 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471852009780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852009781 active site 471852009782 phosphorylation site [posttranslational modification] 471852009783 intermolecular recognition site; other site 471852009784 dimerization interface [polypeptide binding]; other site 471852009785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 471852009786 DNA binding site [nucleotide binding] 471852009787 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 471852009788 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 471852009789 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 471852009790 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 471852009791 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 471852009792 Ferritin-like domain; Region: Ferritin; pfam00210 471852009793 heme binding site [chemical binding]; other site 471852009794 ferroxidase pore; other site 471852009795 ferroxidase diiron center [ion binding]; other site 471852009796 cyclase homology domain; Region: CHD; cd07302 471852009797 nucleotidyl binding site; other site 471852009798 metal binding site [ion binding]; metal-binding site 471852009799 dimer interface [polypeptide binding]; other site 471852009800 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 471852009801 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 471852009802 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 471852009803 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 471852009804 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 471852009805 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 471852009806 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471852009807 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 471852009808 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 471852009809 putative metal binding site [ion binding]; other site 471852009810 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 471852009811 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 471852009812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471852009813 AlkA N-terminal domain; Region: AlkA_N; cl05528 471852009814 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 471852009815 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471852009816 helix-hairpin-helix signature motif; other site 471852009817 substrate binding pocket [chemical binding]; other site 471852009818 active site 471852009819 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 471852009820 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471852009821 active site 471852009822 DNA binding site [nucleotide binding] 471852009823 Bacterial transcriptional activator domain; Region: BTAD; smart01043 471852009824 TadE-like protein; Region: TadE; pfam07811 471852009825 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 471852009826 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 471852009827 ATP binding site [chemical binding]; other site 471852009828 Walker A motif; other site 471852009829 hexamer interface [polypeptide binding]; other site 471852009830 Walker B motif; other site 471852009831 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-...; Region: PA2301; cd04939 471852009832 putative deacylase active site [active] 471852009833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852009834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852009835 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 471852009836 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852009837 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852009838 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471852009839 dimerization interface [polypeptide binding]; other site 471852009840 putative DNA binding site [nucleotide binding]; other site 471852009841 putative Zn2+ binding site [ion binding]; other site 471852009842 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 471852009843 putative metal binding site [ion binding]; other site 471852009844 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 471852009845 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852009846 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471852009847 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852009848 Predicted ATPase [General function prediction only]; Region: COG3899 471852009849 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852009850 DNA binding residues [nucleotide binding] 471852009851 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 471852009852 transmembrane helices; other site 471852009853 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 471852009854 apolar tunnel; other site 471852009855 heme binding site [chemical binding]; other site 471852009856 dimerization interface [polypeptide binding]; other site 471852009857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471852009858 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 471852009859 Coenzyme A binding pocket [chemical binding]; other site 471852009860 Protein kinase; unclassified specificity; Region: STYKc; smart00221 471852009861 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852009862 active site 471852009863 ATP binding site [chemical binding]; other site 471852009864 substrate binding site [chemical binding]; other site 471852009865 activation loop (A-loop); other site 471852009866 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471852009867 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852009868 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471852009869 Walker A/P-loop; other site 471852009870 ATP binding site [chemical binding]; other site 471852009871 Q-loop/lid; other site 471852009872 ABC transporter signature motif; other site 471852009873 Walker B; other site 471852009874 D-loop; other site 471852009875 H-loop/switch region; other site 471852009876 Predicted transcriptional regulator [Transcription]; Region: COG2378 471852009877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852009878 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 471852009879 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471852009880 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471852009881 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 471852009882 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 471852009883 carboxyltransferase (CT) interaction site; other site 471852009884 biotinylation site [posttranslational modification]; other site 471852009885 peptide chain release factor eRF/aRF, subunit 1; Region: eRF; TIGR00108 471852009886 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 471852009887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852009888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852009889 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471852009890 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 471852009891 putative active site pocket [active] 471852009892 dimerization interface [polypeptide binding]; other site 471852009893 putative catalytic residue [active] 471852009894 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 471852009895 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 471852009896 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 471852009897 active site 471852009898 substrate binding site [chemical binding]; other site 471852009899 metal binding site [ion binding]; metal-binding site 471852009900 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 471852009901 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 471852009902 active site 471852009903 purine riboside binding site [chemical binding]; other site 471852009904 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 471852009905 DXD motif; other site 471852009906 cellulose synthase; Region: PLN02400 471852009907 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 471852009908 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 471852009909 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 471852009910 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471852009911 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471852009912 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 471852009913 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 471852009914 active site 471852009915 catalytic motif [active] 471852009916 Zn binding site [ion binding]; other site 471852009917 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 471852009918 ligand binding site [chemical binding]; other site 471852009919 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 471852009920 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 471852009921 Walker A/P-loop; other site 471852009922 ATP binding site [chemical binding]; other site 471852009923 Q-loop/lid; other site 471852009924 ABC transporter signature motif; other site 471852009925 Walker B; other site 471852009926 D-loop; other site 471852009927 H-loop/switch region; other site 471852009928 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 471852009929 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471852009930 TM-ABC transporter signature motif; other site 471852009931 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 471852009932 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471852009933 TM-ABC transporter signature motif; other site 471852009934 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471852009935 classical (c) SDRs; Region: SDR_c; cd05233 471852009936 NAD(P) binding site [chemical binding]; other site 471852009937 active site 471852009938 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852009939 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 471852009940 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 471852009941 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 471852009942 putative dimer interface [polypeptide binding]; other site 471852009943 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471852009944 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 471852009945 metal binding site [ion binding]; metal-binding site 471852009946 putative dimer interface [polypeptide binding]; other site 471852009947 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 471852009948 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 471852009949 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 471852009950 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 471852009951 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 471852009952 hypothetical protein; Provisional; Region: PRK13679 471852009953 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 471852009954 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 471852009955 active site 471852009956 HIGH motif; other site 471852009957 dimer interface [polypeptide binding]; other site 471852009958 KMSKS motif; other site 471852009959 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 471852009960 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 471852009961 NAD binding site [chemical binding]; other site 471852009962 homodimer interface [polypeptide binding]; other site 471852009963 active site 471852009964 substrate binding site [chemical binding]; other site 471852009965 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 471852009966 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 471852009967 HSP90 family protein; Provisional; Region: PRK14083 471852009968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852009969 ATP binding site [chemical binding]; other site 471852009970 Mg2+ binding site [ion binding]; other site 471852009971 G-X-G motif; other site 471852009972 malate dehydrogenase; Provisional; Region: PRK05442 471852009973 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 471852009974 NAD(P) binding site [chemical binding]; other site 471852009975 dimer interface [polypeptide binding]; other site 471852009976 malate binding site [chemical binding]; other site 471852009977 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 471852009978 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 471852009979 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471852009980 phosphopeptide binding site; other site 471852009981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852009982 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 471852009983 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 471852009984 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 471852009985 homodimer interface [polypeptide binding]; other site 471852009986 NADP binding site [chemical binding]; other site 471852009987 substrate binding site [chemical binding]; other site 471852009988 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 471852009989 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 471852009990 purine monophosphate binding site [chemical binding]; other site 471852009991 dimer interface [polypeptide binding]; other site 471852009992 putative catalytic residues [active] 471852009993 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 471852009994 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 471852009995 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 471852009996 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 471852009997 active site 471852009998 substrate binding site [chemical binding]; other site 471852009999 cosubstrate binding site; other site 471852010000 catalytic site [active] 471852010001 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 471852010002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852010003 CoA-ligase; Region: Ligase_CoA; pfam00549 471852010004 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 471852010005 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471852010006 CoA-ligase; Region: Ligase_CoA; pfam00549 471852010007 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 471852010008 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 471852010009 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 471852010010 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471852010011 UvrD/REP helicase; Region: UvrD-helicase; cl14126 471852010012 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 471852010013 putative hydrophobic ligand binding site [chemical binding]; other site 471852010014 protein interface [polypeptide binding]; other site 471852010015 DinB superfamily; Region: DinB_2; cl00986 471852010016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852010017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852010018 active site 471852010019 phosphorylation site [posttranslational modification] 471852010020 intermolecular recognition site; other site 471852010021 dimerization interface [polypeptide binding]; other site 471852010022 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852010023 DNA binding residues [nucleotide binding] 471852010024 dimerization interface [polypeptide binding]; other site 471852010025 PspC domain; Region: PspC; cl00864 471852010026 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471852010027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852010028 PspC domain; Region: PspC; cl00864 471852010029 Cysteine dioxygenase type I; Region: CDO_I; cl02350 471852010030 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 471852010031 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471852010032 putative active site [active] 471852010033 putative metal binding site [ion binding]; other site 471852010034 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471852010035 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471852010036 EamA-like transporter family; Region: EamA; cl01037 471852010037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852010038 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471852010039 dimerization interface [polypeptide binding]; other site 471852010040 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471852010041 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471852010042 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 471852010043 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 471852010044 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471852010045 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 471852010046 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 471852010047 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 471852010048 putative hydrophobic ligand binding site [chemical binding]; other site 471852010049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852010050 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471852010051 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471852010052 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 471852010053 putative ADP-binding pocket [chemical binding]; other site 471852010054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852010055 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 471852010056 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 471852010057 dimerization interface [polypeptide binding]; other site 471852010058 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 471852010059 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 471852010060 dimer interface [polypeptide binding]; other site 471852010061 decamer (pentamer of dimers) interface [polypeptide binding]; other site 471852010062 catalytic triad [active] 471852010063 peroxidatic and resolving cysteines [active] 471852010064 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 471852010065 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 471852010066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852010067 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471852010068 putative active site [active] 471852010069 GMP synthase; Reviewed; Region: guaA; PRK00074 471852010070 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 471852010071 AMP/PPi binding site [chemical binding]; other site 471852010072 candidate oxyanion hole; other site 471852010073 catalytic triad [active] 471852010074 potential glutamine specificity residues [chemical binding]; other site 471852010075 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 471852010076 ATP Binding subdomain [chemical binding]; other site 471852010077 Ligand Binding sites [chemical binding]; other site 471852010078 Dimerization subdomain; other site 471852010079 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471852010080 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471852010081 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471852010082 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 471852010083 NAD(P) binding site [chemical binding]; other site 471852010084 catalytic residues [active] 471852010085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852010086 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 471852010087 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 471852010088 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 471852010089 active site 471852010090 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 471852010091 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471852010092 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 471852010093 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 471852010094 active site 471852010095 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 471852010096 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852010097 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852010098 DNA binding residues [nucleotide binding] 471852010099 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471852010100 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 471852010101 ring oligomerisation interface [polypeptide binding]; other site 471852010102 ATP/Mg binding site [chemical binding]; other site 471852010103 stacking interactions; other site 471852010104 hinge regions; other site 471852010105 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 471852010106 oligomerisation interface [polypeptide binding]; other site 471852010107 mobile loop; other site 471852010108 roof hairpin; other site 471852010109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852010110 Phosphotransferase enzyme family; Region: APH; pfam01636 471852010111 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471852010112 active site 471852010113 substrate binding site [chemical binding]; other site 471852010114 ATP binding site [chemical binding]; other site 471852010115 putative glycoprotease GCP; Region: bact_gcp; TIGR03723 471852010116 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 471852010117 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 471852010118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852010119 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 471852010120 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 471852010121 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471852010122 alanine racemase; Reviewed; Region: alr; PRK00053 471852010123 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 471852010124 active site 471852010125 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471852010126 dimer interface [polypeptide binding]; other site 471852010127 substrate binding site [chemical binding]; other site 471852010128 catalytic residues [active] 471852010129 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 471852010130 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 471852010131 putative substrate binding site [chemical binding]; other site 471852010132 putative ATP binding site [chemical binding]; other site 471852010133 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 471852010134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852010135 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852010136 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852010137 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 471852010138 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 471852010139 glutaminase active site [active] 471852010140 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471852010141 dimer interface [polypeptide binding]; other site 471852010142 active site 471852010143 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471852010144 dimer interface [polypeptide binding]; other site 471852010145 active site 471852010146 pantothenate kinase; Provisional; Region: PRK05439 471852010147 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 471852010148 ATP-binding site [chemical binding]; other site 471852010149 CoA-binding site [chemical binding]; other site 471852010150 Mg2+-binding site [ion binding]; other site 471852010151 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471852010152 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471852010153 Walker A/P-loop; other site 471852010154 ATP binding site [chemical binding]; other site 471852010155 Q-loop/lid; other site 471852010156 ABC transporter signature motif; other site 471852010157 Walker B; other site 471852010158 D-loop; other site 471852010159 H-loop/switch region; other site 471852010160 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471852010161 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852010162 Walker A/P-loop; other site 471852010163 ATP binding site [chemical binding]; other site 471852010164 Q-loop/lid; other site 471852010165 ABC transporter signature motif; other site 471852010166 Walker B; other site 471852010167 D-loop; other site 471852010168 H-loop/switch region; other site 471852010169 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 471852010170 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 471852010171 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 471852010172 active site 471852010173 substrate binding site [chemical binding]; other site 471852010174 metal binding site [ion binding]; metal-binding site 471852010175 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 471852010176 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 471852010177 23S rRNA interface [nucleotide binding]; other site 471852010178 L3 interface [polypeptide binding]; other site 471852010179 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 471852010180 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 471852010181 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 471852010182 dimerization interface 3.5A [polypeptide binding]; other site 471852010183 active site 471852010184 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 471852010185 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 471852010186 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 471852010187 alphaNTD homodimer interface [polypeptide binding]; other site 471852010188 alphaNTD - beta interaction site [polypeptide binding]; other site 471852010189 alphaNTD - beta' interaction site [polypeptide binding]; other site 471852010190 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 471852010191 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 471852010192 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 471852010193 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471852010194 RNA binding surface [nucleotide binding]; other site 471852010195 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 471852010196 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 471852010197 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 471852010198 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 471852010199 rRNA binding site [nucleotide binding]; other site 471852010200 predicted 30S ribosome binding site; other site 471852010201 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 471852010202 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471852010203 active site 471852010204 metal binding site [ion binding]; metal-binding site 471852010205 hexamer interface [polypeptide binding]; other site 471852010206 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 471852010207 methionine aminopeptidase; Reviewed; Region: PRK07281 471852010208 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471852010209 active site 471852010210 adenylate kinase; Reviewed; Region: adk; PRK00279 471852010211 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 471852010212 AMP-binding site [chemical binding]; other site 471852010213 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 471852010214 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 471852010215 SecY translocase; Region: SecY; pfam00344 471852010216 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 471852010217 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 471852010218 23S rRNA binding site [nucleotide binding]; other site 471852010219 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 471852010220 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 471852010221 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 471852010222 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 471852010223 5S rRNA interface [nucleotide binding]; other site 471852010224 L27 interface [polypeptide binding]; other site 471852010225 23S rRNA interface [nucleotide binding]; other site 471852010226 L5 interface [polypeptide binding]; other site 471852010227 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 471852010228 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471852010229 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471852010230 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 471852010231 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 471852010232 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 471852010233 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 471852010234 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 471852010235 KOW motif; Region: KOW; cl00354 471852010236 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 471852010237 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 471852010238 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 471852010239 23S rRNA interface [nucleotide binding]; other site 471852010240 putative translocon interaction site; other site 471852010241 signal recognition particle (SRP54) interaction site; other site 471852010242 L23 interface [polypeptide binding]; other site 471852010243 trigger factor interaction site; other site 471852010244 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 471852010245 23S rRNA interface [nucleotide binding]; other site 471852010246 5S rRNA interface [nucleotide binding]; other site 471852010247 putative antibiotic binding site [chemical binding]; other site 471852010248 L25 interface [polypeptide binding]; other site 471852010249 L27 interface [polypeptide binding]; other site 471852010250 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 471852010251 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 471852010252 G-X-X-G motif; other site 471852010253 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 471852010254 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 471852010255 putative translocon binding site; other site 471852010256 protein-rRNA interface [nucleotide binding]; other site 471852010257 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 471852010258 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 471852010259 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 471852010260 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 471852010261 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 471852010262 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 471852010263 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 471852010264 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 471852010265 elongation factor Tu; Reviewed; Region: PRK00049 471852010266 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 471852010267 G1 box; other site 471852010268 GEF interaction site [polypeptide binding]; other site 471852010269 GTP/Mg2+ binding site [chemical binding]; other site 471852010270 Switch I region; other site 471852010271 G2 box; other site 471852010272 G3 box; other site 471852010273 Switch II region; other site 471852010274 G4 box; other site 471852010275 G5 box; other site 471852010276 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 471852010277 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 471852010278 Antibiotic Binding Site [chemical binding]; other site 471852010279 elongation factor G; Reviewed; Region: PRK00007 471852010280 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 471852010281 G1 box; other site 471852010282 putative GEF interaction site [polypeptide binding]; other site 471852010283 GTP/Mg2+ binding site [chemical binding]; other site 471852010284 Switch I region; other site 471852010285 G2 box; other site 471852010286 G3 box; other site 471852010287 Switch II region; other site 471852010288 G4 box; other site 471852010289 G5 box; other site 471852010290 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 471852010291 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 471852010292 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 471852010293 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 471852010294 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 471852010295 S17 interaction site [polypeptide binding]; other site 471852010296 S8 interaction site; other site 471852010297 16S rRNA interaction site [nucleotide binding]; other site 471852010298 streptomycin interaction site [chemical binding]; other site 471852010299 23S rRNA interaction site [nucleotide binding]; other site 471852010300 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 471852010301 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 471852010302 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471852010303 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471852010304 FtsX-like permease family; Region: FtsX; pfam02687 471852010305 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471852010306 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471852010307 Walker A/P-loop; other site 471852010308 ATP binding site [chemical binding]; other site 471852010309 Q-loop/lid; other site 471852010310 ABC transporter signature motif; other site 471852010311 Walker B; other site 471852010312 D-loop; other site 471852010313 H-loop/switch region; other site 471852010314 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471852010315 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471852010316 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852010317 DNA binding residues [nucleotide binding] 471852010318 dimerization interface [polypeptide binding]; other site 471852010319 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471852010320 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852010321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852010322 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 471852010323 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471852010324 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 471852010325 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 471852010326 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 471852010327 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 471852010328 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 471852010329 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 471852010330 G-loop; other site 471852010331 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 471852010332 DNA binding site [nucleotide binding] 471852010333 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 471852010334 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 471852010335 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471852010336 RPB12 interaction site [polypeptide binding]; other site 471852010337 RPB1 interaction site [polypeptide binding]; other site 471852010338 RPB10 interaction site [polypeptide binding]; other site 471852010339 RPB11 interaction site [polypeptide binding]; other site 471852010340 RPB3 interaction site [polypeptide binding]; other site 471852010341 mce related protein; Region: MCE; pfam02470 471852010342 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471852010343 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471852010344 mce related protein; Region: MCE; pfam02470 471852010345 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471852010346 mce related protein; Region: MCE; pfam02470 471852010347 mce related protein; Region: MCE; pfam02470 471852010348 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471852010349 mce related protein; Region: MCE; pfam02470 471852010350 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 471852010351 mce related protein; Region: MCE; pfam02470 471852010352 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 471852010353 Domain of unknown function DUF140; Region: DUF140; cl00510 471852010354 Domain of unknown function DUF140; Region: DUF140; cl00510 471852010355 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 471852010356 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 471852010357 Walker A/P-loop; other site 471852010358 ATP binding site [chemical binding]; other site 471852010359 Q-loop/lid; other site 471852010360 ABC transporter signature motif; other site 471852010361 Walker B; other site 471852010362 D-loop; other site 471852010363 H-loop/switch region; other site 471852010364 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 471852010365 core dimer interface [polypeptide binding]; other site 471852010366 peripheral dimer interface [polypeptide binding]; other site 471852010367 L10 interface [polypeptide binding]; other site 471852010368 L11 interface [polypeptide binding]; other site 471852010369 putative EF-Tu interaction site [polypeptide binding]; other site 471852010370 putative EF-G interaction site [polypeptide binding]; other site 471852010371 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 471852010372 23S rRNA interface [nucleotide binding]; other site 471852010373 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 471852010374 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 471852010375 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 471852010376 mRNA/rRNA interface [nucleotide binding]; other site 471852010377 Ribosomal protein L11/L12; Region: RL11; smart00649 471852010378 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 471852010379 23S rRNA interface [nucleotide binding]; other site 471852010380 L7/L12 interface [polypeptide binding]; other site 471852010381 putative thiostrepton binding site; other site 471852010382 L25 interface [polypeptide binding]; other site 471852010383 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 471852010384 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 471852010385 putative homodimer interface [polypeptide binding]; other site 471852010386 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 471852010387 hypothetical protein; Validated; Region: PRK07682 471852010388 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471852010389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852010390 homodimer interface [polypeptide binding]; other site 471852010391 catalytic residue [active] 471852010392 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 471852010393 active site 471852010394 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471852010395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852010396 DNA-binding site [nucleotide binding]; DNA binding site 471852010397 FCD domain; Region: FCD; cl11656 471852010398 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 471852010399 FAD binding domain; Region: FAD_binding_4; pfam01565 471852010400 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 471852010401 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 471852010402 active site 471852010403 catalytic site [active] 471852010404 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 471852010405 active site 471852010406 catalytic site [active] 471852010407 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 471852010408 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 471852010409 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471852010410 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852010411 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 471852010412 active site 471852010413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852010414 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 471852010415 Phage integrase family; Region: Phage_integrase; pfam00589 471852010416 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 471852010417 DNA binding site [nucleotide binding] 471852010418 Int/Topo IB signature motif; other site 471852010419 active site 471852010420 catalytic residues [active] 471852010421 Protein of unknown function (DUF520); Region: DUF520; cl00723 471852010422 methionine aminopeptidase; Reviewed; Region: PRK07281 471852010423 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471852010424 active site 471852010425 Peptidase family M48; Region: Peptidase_M48; cl12018 471852010426 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471852010427 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 471852010428 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471852010429 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471852010430 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 471852010431 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 471852010432 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 471852010433 4Fe-4S binding domain; Region: Fer4; cl02805 471852010434 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 471852010435 NADH dehydrogenase; Region: NADHdh; cl00469 471852010436 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 471852010437 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 471852010438 retinal-specific rim ABC transporter; Region: rim_protein; TIGR01257 471852010439 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 471852010440 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 471852010441 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 471852010442 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 471852010443 dimer interface [polypeptide binding]; other site 471852010444 PYR/PP interface [polypeptide binding]; other site 471852010445 TPP binding site [chemical binding]; other site 471852010446 substrate binding site [chemical binding]; other site 471852010447 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 471852010448 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 471852010449 TPP-binding site [chemical binding]; other site 471852010450 protein-export membrane protein SecD; Region: secD; TIGR01129 471852010451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852010452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852010453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852010454 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471852010455 putative substrate translocation pore; other site 471852010456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852010457 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 471852010458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852010459 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 471852010460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852010461 NAD(P) binding site [chemical binding]; other site 471852010462 active site 471852010463 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 471852010464 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471852010465 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 471852010466 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 471852010467 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 471852010468 Predicted permeases [General function prediction only]; Region: RarD; COG2962 471852010469 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471852010470 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471852010471 substrate binding pocket [chemical binding]; other site 471852010472 chain length determination region; other site 471852010473 substrate-Mg2+ binding site; other site 471852010474 catalytic residues [active] 471852010475 aspartate-rich region 1; other site 471852010476 active site lid residues [active] 471852010477 aspartate-rich region 2; other site 471852010478 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 471852010479 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471852010480 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 471852010481 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471852010482 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 471852010483 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 471852010484 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471852010485 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 471852010486 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 471852010487 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 471852010488 4Fe-4S binding domain; Region: Fer4; cl02805 471852010489 4Fe-4S binding domain; Region: Fer4; cl02805 471852010490 NADH dehydrogenase; Region: NADHdh; cl00469 471852010491 NADH dehydrogenase subunit G; Validated; Region: PRK07860 471852010492 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471852010493 catalytic loop [active] 471852010494 iron binding site [ion binding]; other site 471852010495 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 471852010496 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 471852010497 molybdopterin cofactor binding site; other site 471852010498 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 471852010499 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 471852010500 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 471852010501 SLBB domain; Region: SLBB; pfam10531 471852010502 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 471852010503 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 471852010504 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 471852010505 putative dimer interface [polypeptide binding]; other site 471852010506 [2Fe-2S] cluster binding site [ion binding]; other site 471852010507 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 471852010508 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 471852010509 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 471852010510 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 471852010511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852010512 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 471852010513 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 471852010514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852010515 S-adenosylmethionine binding site [chemical binding]; other site 471852010516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852010517 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 471852010518 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471852010519 tetramer interface [polypeptide binding]; other site 471852010520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852010521 catalytic residue [active] 471852010522 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 471852010523 DNA binding residues [nucleotide binding] 471852010524 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 471852010525 ResB-like family; Region: ResB; pfam05140 471852010526 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 471852010527 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 471852010528 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 471852010529 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 471852010530 catalytic residues [active] 471852010531 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 471852010532 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471852010533 catalytic core [active] 471852010534 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 471852010535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852010536 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 471852010537 putative dimerization interface [polypeptide binding]; other site 471852010538 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 471852010539 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 471852010540 inhibitor-cofactor binding pocket; inhibition site 471852010541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852010542 catalytic residue [active] 471852010543 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852010544 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852010545 active site 471852010546 ATP binding site [chemical binding]; other site 471852010547 substrate binding site [chemical binding]; other site 471852010548 activation loop (A-loop); other site 471852010549 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 471852010550 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 471852010551 dimer interface [polypeptide binding]; other site 471852010552 active site 471852010553 Schiff base residues; other site 471852010554 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 471852010555 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 471852010556 active site 471852010557 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 471852010558 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 471852010559 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 471852010560 domain interfaces; other site 471852010561 active site 471852010562 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 471852010563 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 471852010564 tRNA; other site 471852010565 putative tRNA binding site [nucleotide binding]; other site 471852010566 putative NADP binding site [chemical binding]; other site 471852010567 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 471852010568 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 471852010569 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 471852010570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852010571 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471852010572 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 471852010573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852010574 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852010575 DNA binding residues [nucleotide binding] 471852010576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471852010577 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 471852010578 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 471852010579 putative acyl-acceptor binding pocket; other site 471852010580 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 471852010581 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471852010582 putative NAD(P) binding site [chemical binding]; other site 471852010583 active site 471852010584 putative substrate binding site [chemical binding]; other site 471852010585 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471852010586 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 471852010587 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 471852010588 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852010589 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471852010590 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852010591 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471852010592 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471852010593 FtsX-like permease family; Region: FtsX; pfam02687 471852010594 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471852010595 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471852010596 Walker A/P-loop; other site 471852010597 ATP binding site [chemical binding]; other site 471852010598 Q-loop/lid; other site 471852010599 ABC transporter signature motif; other site 471852010600 Walker B; other site 471852010601 D-loop; other site 471852010602 H-loop/switch region; other site 471852010603 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471852010604 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 471852010605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852010606 Proline dehydrogenase; Region: Pro_dh; cl03282 471852010607 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471852010608 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471852010609 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 471852010610 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852010611 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471852010612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852010613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852010614 S-adenosylmethionine binding site [chemical binding]; other site 471852010615 DNA repair protein RadA; Provisional; Region: PRK11823 471852010616 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852010617 Walker A motif; other site 471852010618 ATP binding site [chemical binding]; other site 471852010619 Walker B motif; other site 471852010620 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 471852010621 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 471852010622 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 471852010623 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852010624 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471852010625 endonuclease III; Region: ENDO3c; smart00478 471852010626 minor groove reading motif; other site 471852010627 helix-hairpin-helix signature motif; other site 471852010628 substrate binding pocket [chemical binding]; other site 471852010629 active site 471852010630 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471852010631 Clp protease ATP binding subunit; Region: clpC; CHL00095 471852010632 Clp amino terminal domain; Region: Clp_N; pfam02861 471852010633 Clp amino terminal domain; Region: Clp_N; pfam02861 471852010634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852010635 Walker A motif; other site 471852010636 ATP binding site [chemical binding]; other site 471852010637 Walker B motif; other site 471852010638 arginine finger; other site 471852010639 UvrB/uvrC motif; Region: UVR; pfam02151 471852010640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852010641 Walker A motif; other site 471852010642 ATP binding site [chemical binding]; other site 471852010643 Walker B motif; other site 471852010644 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471852010645 Lsr2; Region: Lsr2; pfam11774 471852010646 RDD family; Region: RDD; cl00746 471852010647 RDD family; Region: RDD; cl00746 471852010648 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 471852010649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471852010650 Coenzyme A binding pocket [chemical binding]; other site 471852010651 NlpC/P60 family; Region: NLPC_P60; cl11438 471852010652 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 471852010653 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 471852010654 dimer interface [polypeptide binding]; other site 471852010655 putative anticodon binding site; other site 471852010656 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 471852010657 motif 1; other site 471852010658 active site 471852010659 motif 2; other site 471852010660 motif 3; other site 471852010661 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 471852010662 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 471852010663 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 471852010664 dimerization interface [polypeptide binding]; other site 471852010665 active site 471852010666 L-aspartate oxidase; Provisional; Region: PRK07804 471852010667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852010668 domain; Region: Succ_DH_flav_C; pfam02910 471852010669 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 471852010670 tetramerization interface [polypeptide binding]; other site 471852010671 active site 471852010672 Pantoate-beta-alanine ligase; Region: PanC; cd00560 471852010673 pantoate--beta-alanine ligase; Region: panC; TIGR00018 471852010674 active site 471852010675 ATP-binding site [chemical binding]; other site 471852010676 pantoate-binding site; other site 471852010677 HXXH motif; other site 471852010678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852010679 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 471852010680 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 471852010681 FtsX-like permease family; Region: FtsX; pfam02687 471852010682 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 471852010683 FtsX-like permease family; Region: FtsX; pfam02687 471852010684 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471852010685 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471852010686 Walker A/P-loop; other site 471852010687 ATP binding site [chemical binding]; other site 471852010688 Q-loop/lid; other site 471852010689 ABC transporter signature motif; other site 471852010690 Walker B; other site 471852010691 D-loop; other site 471852010692 H-loop/switch region; other site 471852010693 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852010694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852010695 active site 471852010696 phosphorylation site [posttranslational modification] 471852010697 intermolecular recognition site; other site 471852010698 dimerization interface [polypeptide binding]; other site 471852010699 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852010700 dimerization interface [polypeptide binding]; other site 471852010701 DNA binding residues [nucleotide binding] 471852010702 Histidine kinase; Region: HisKA_3; pfam07730 471852010703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852010704 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 471852010705 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471852010706 putative active site [active] 471852010707 Predicted membrane protein [Function unknown]; Region: COG3428 471852010708 Bacterial membrane flanked domain; Region: DUF304; cl01348 471852010709 Bacterial membrane flanked domain; Region: DUF304; cl01348 471852010710 Bacterial membrane flanked domain; Region: DUF304; cl01348 471852010711 Bacterial membrane flanked domain; Region: DUF304; cl01348 471852010712 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 471852010713 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 471852010714 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 471852010715 catalytic center binding site [active] 471852010716 ATP binding site [chemical binding]; other site 471852010717 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 471852010718 homooctamer interface [polypeptide binding]; other site 471852010719 active site 471852010720 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 471852010721 Pterin binding enzyme; Region: Pterin_bind; pfam00809 471852010722 substrate binding pocket [chemical binding]; other site 471852010723 inhibitor binding site; inhibition site 471852010724 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 471852010725 homodecamer interface [polypeptide binding]; other site 471852010726 GTP cyclohydrolase I; Provisional; Region: PLN03044 471852010727 active site 471852010728 putative catalytic site residues [active] 471852010729 zinc binding site [ion binding]; other site 471852010730 GTP-CH-I/GFRP interaction surface; other site 471852010731 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 471852010732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852010733 Walker A motif; other site 471852010734 ATP binding site [chemical binding]; other site 471852010735 Walker B motif; other site 471852010736 arginine finger; other site 471852010737 Peptidase family M41; Region: Peptidase_M41; pfam01434 471852010738 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471852010739 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 471852010740 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 471852010741 PBP4 family; Region: PBP4; TIGR00666 471852010742 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 471852010743 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 471852010744 dimer interface [polypeptide binding]; other site 471852010745 substrate binding site [chemical binding]; other site 471852010746 metal binding sites [ion binding]; metal-binding site 471852010747 NlpC/P60 family; Region: NLPC_P60; cl11438 471852010748 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471852010749 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471852010750 Vault protein inter-alpha-trypsin; Region: VIT; cl02699 471852010751 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 471852010752 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471852010753 metal ion-dependent adhesion site (MIDAS); other site 471852010754 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471852010755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852010756 DNA-binding site [nucleotide binding]; DNA binding site 471852010757 UTRA domain; Region: UTRA; cl01230 471852010758 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471852010759 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852010760 DNA-binding site [nucleotide binding]; DNA binding site 471852010761 UTRA domain; Region: UTRA; cl01230 471852010762 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471852010763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471852010764 Archaeal ATPase; Region: Arch_ATPase; pfam01637 471852010765 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 471852010766 binding surface 471852010767 TPR motif; other site 471852010768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 471852010769 binding surface 471852010770 TPR motif; other site 471852010771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 471852010772 binding surface 471852010773 TPR motif; other site 471852010774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 471852010775 binding surface 471852010776 TPR motif; other site 471852010777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852010778 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852010779 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 471852010780 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471852010781 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 471852010782 Phage integrase family; Region: Phage_integrase; pfam00589 471852010783 Int/Topo IB signature motif; other site 471852010784 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 471852010785 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852010786 Domain of unknown function (DUF427); Region: DUF427; cl00998 471852010787 Domain of unknown function (DUF427); Region: DUF427; cl00998 471852010788 PSP1 C-terminal conserved region; Region: PSP1; cl00770 471852010789 Phosphotransferase enzyme family; Region: APH; pfam01636 471852010790 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852010791 active site 471852010792 ATP binding site [chemical binding]; other site 471852010793 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471852010794 Active site [active] 471852010795 DNA polymerase III subunit delta'; Validated; Region: PRK07940 471852010796 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852010797 H+ Antiporter protein; Region: 2A0121; TIGR00900 471852010798 thymidylate kinase; Validated; Region: tmk; PRK00698 471852010799 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 471852010800 TMP-binding site; other site 471852010801 ATP-binding site [chemical binding]; other site 471852010802 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 471852010803 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 471852010804 active site 471852010805 interdomain interaction site; other site 471852010806 putative metal-binding site [ion binding]; other site 471852010807 nucleotide binding site [chemical binding]; other site 471852010808 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 471852010809 domain I; other site 471852010810 DNA binding groove [nucleotide binding] 471852010811 phosphate binding site [ion binding]; other site 471852010812 domain II; other site 471852010813 domain III; other site 471852010814 nucleotide binding site [chemical binding]; other site 471852010815 catalytic site [active] 471852010816 domain IV; other site 471852010817 hypothetical protein; Provisional; Region: PRK07906 471852010818 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 471852010819 putative metal binding site [ion binding]; other site 471852010820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852010821 Predicted transcriptional regulator [Transcription]; Region: COG2378 471852010822 Epoxide hydrolase N terminus; Region: EHN; pfam06441 471852010823 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471852010824 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852010825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852010826 active site 471852010827 phosphorylation site [posttranslational modification] 471852010828 intermolecular recognition site; other site 471852010829 dimerization interface [polypeptide binding]; other site 471852010830 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852010831 DNA binding residues [nucleotide binding] 471852010832 dimerization interface [polypeptide binding]; other site 471852010833 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471852010834 SpoOM protein; Region: Spo0M; pfam07070 471852010835 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 471852010836 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 471852010837 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099 471852010838 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 471852010839 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 471852010840 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852010841 Leucine carboxyl methyltransferase; Region: LCM; cl01306 471852010842 Uncharacterized conserved protein [Function unknown]; Region: COG2128 471852010843 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 471852010844 Chitin binding domain; Region: Chitin_bind_3; cl03871 471852010845 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471852010846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852010847 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471852010848 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471852010849 DNA binding site [nucleotide binding] 471852010850 domain linker motif; other site 471852010851 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 471852010852 putative dimerization interface [polypeptide binding]; other site 471852010853 putative ligand binding site [chemical binding]; other site 471852010854 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 471852010855 putative active site [active] 471852010856 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471852010857 ligand binding site [chemical binding]; other site 471852010858 flexible hinge region; other site 471852010859 cyclase homology domain; Region: CHD; cd07302 471852010860 nucleotidyl binding site; other site 471852010861 metal binding site [ion binding]; metal-binding site 471852010862 dimer interface [polypeptide binding]; other site 471852010863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471852010864 non-specific DNA binding site [nucleotide binding]; other site 471852010865 salt bridge; other site 471852010866 sequence-specific DNA binding site [nucleotide binding]; other site 471852010867 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852010868 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852010869 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 471852010870 active site 471852010871 dimer interface [polypeptide binding]; other site 471852010872 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 471852010873 active site 471852010874 dimer interface [polypeptide binding]; other site 471852010875 Acylphosphatase; Region: Acylphosphatase; cl00551 471852010876 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 471852010877 HypF finger; Region: zf-HYPF; pfam07503 471852010878 HypF finger; Region: zf-HYPF; pfam07503 471852010879 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 471852010880 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 471852010881 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471852010882 putative catalytic site [active] 471852010883 putative metal binding site [ion binding]; other site 471852010884 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471852010885 putative phosphate binding site [ion binding]; other site 471852010886 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 471852010887 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852010888 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 471852010889 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal...; Region: PurM-like; cl10019 471852010890 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 471852010891 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 471852010892 dimerization interface [polypeptide binding]; other site 471852010893 ATP binding site [chemical binding]; other site 471852010894 Hydrogenase formation hypA family; Region: HypD; cl12072 471852010895 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 471852010896 HupF/HypC family; Region: HupF_HypC; cl00394 471852010897 NifU-like domain; Region: NifU; cl00484 471852010898 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 471852010899 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 471852010900 Hydrogenase expression/synthesis hypA family; Region: HypA; cl00418 471852010901 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 471852010902 nickel binding site [ion binding]; other site 471852010903 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852010904 ATP binding site [chemical binding]; other site 471852010905 putative Mg++ binding site [ion binding]; other site 471852010906 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471852010907 nucleotide binding region [chemical binding]; other site 471852010908 ATP-binding site [chemical binding]; other site 471852010909 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 471852010910 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 471852010911 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471852010912 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471852010913 Walker A/P-loop; other site 471852010914 ATP binding site [chemical binding]; other site 471852010915 Q-loop/lid; other site 471852010916 ABC transporter signature motif; other site 471852010917 Walker B; other site 471852010918 D-loop; other site 471852010919 H-loop/switch region; other site 471852010920 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 471852010921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852010922 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 471852010923 DNA-binding interface [nucleotide binding]; DNA binding site 471852010924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852010925 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852010926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852010927 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852010928 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471852010929 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852010930 active site 471852010931 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852010932 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 471852010933 FAD binding site [chemical binding]; other site 471852010934 substrate binding site [chemical binding]; other site 471852010935 catalytic base [active] 471852010936 enoyl-CoA hydratase; Provisional; Region: PRK08290 471852010937 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852010938 substrate binding site [chemical binding]; other site 471852010939 oxyanion hole (OAH) forming residues; other site 471852010940 trimer interface [polypeptide binding]; other site 471852010941 short chain dehydrogenase; Provisional; Region: PRK07831 471852010942 classical (c) SDRs; Region: SDR_c; cd05233 471852010943 NAD(P) binding site [chemical binding]; other site 471852010944 active site 471852010945 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 471852010946 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471852010947 dimer interface [polypeptide binding]; other site 471852010948 active site 471852010949 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471852010950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852010951 DNA-binding site [nucleotide binding]; DNA binding site 471852010952 FCD domain; Region: FCD; cl11656 471852010953 enoyl-CoA hydratase; Provisional; Region: PRK07938 471852010954 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852010955 substrate binding site [chemical binding]; other site 471852010956 oxyanion hole (OAH) forming residues; other site 471852010957 trimer interface [polypeptide binding]; other site 471852010958 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471852010959 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471852010960 Nitronate monooxygenase; Region: NMO; pfam03060 471852010961 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 471852010962 FMN binding site [chemical binding]; other site 471852010963 substrate binding site [chemical binding]; other site 471852010964 putative catalytic residue [active] 471852010965 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471852010966 Domain of unknown function DUF20; Region: UPF0118; cl00465 471852010967 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 471852010968 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 471852010969 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471852010970 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 471852010971 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471852010972 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 471852010973 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471852010974 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471852010975 active site 471852010976 Uncharacterized conserved protein [Function unknown]; Region: COG3777 471852010977 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471852010978 active site 2 [active] 471852010979 active site 1 [active] 471852010980 CoA-transferase family III; Region: CoA_transf_3; cl00778 471852010981 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471852010982 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852010983 DNA-binding site [nucleotide binding]; DNA binding site 471852010984 FCD domain; Region: FCD; cl11656 471852010985 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852010986 Leucine carboxyl methyltransferase; Region: LCM; cl01306 471852010987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852010988 S-adenosylmethionine binding site [chemical binding]; other site 471852010989 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852010990 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 471852010991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 471852010992 TPR motif; other site 471852010993 binding surface 471852010994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852010995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852010996 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 471852010997 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 471852010998 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 471852010999 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-...; Region: LanC; cd04793 471852011000 active site 471852011001 zinc binding site [ion binding]; other site 471852011002 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 471852011003 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 471852011004 nudix motif; other site 471852011005 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852011006 DNA-binding site [nucleotide binding]; DNA binding site 471852011007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852011008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852011009 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471852011010 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471852011011 Walker A/P-loop; other site 471852011012 ATP binding site [chemical binding]; other site 471852011013 Q-loop/lid; other site 471852011014 ABC transporter signature motif; other site 471852011015 Walker B; other site 471852011016 D-loop; other site 471852011017 H-loop/switch region; other site 471852011018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471852011019 Histidine kinase; Region: HisKA_3; pfam07730 471852011020 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471852011021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852011022 active site 471852011023 phosphorylation site [posttranslational modification] 471852011024 intermolecular recognition site; other site 471852011025 dimerization interface [polypeptide binding]; other site 471852011026 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852011027 DNA binding residues [nucleotide binding] 471852011028 dimerization interface [polypeptide binding]; other site 471852011029 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852011030 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 471852011031 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471852011032 Domain of unknown function DUF21; Region: DUF21; pfam01595 471852011033 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471852011034 Transporter associated domain; Region: CorC_HlyC; cl08393 471852011035 Domain of unknown function DUF21; Region: DUF21; pfam01595 471852011036 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471852011037 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 471852011038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852011039 S-adenosylmethionine binding site [chemical binding]; other site 471852011040 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 471852011041 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 471852011042 substrate binding pocket [chemical binding]; other site 471852011043 membrane-bound complex binding site; other site 471852011044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 471852011045 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471852011046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852011047 dimer interface [polypeptide binding]; other site 471852011048 conserved gate region; other site 471852011049 putative PBP binding loops; other site 471852011050 ABC-ATPase subunit interface; other site 471852011051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852011052 O-methyltransferase; Region: Methyltransf_2; pfam00891 471852011053 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 471852011054 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 471852011055 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 471852011056 acyl-CoA synthetase; Validated; Region: PRK07788 471852011057 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852011058 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471852011059 metal ion-dependent adhesion site (MIDAS); other site 471852011060 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471852011061 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 471852011062 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471852011063 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 471852011064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852011065 DNA binding residues [nucleotide binding] 471852011066 dimerization interface [polypeptide binding]; other site 471852011067 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 471852011068 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471852011069 CoenzymeA binding site [chemical binding]; other site 471852011070 subunit interaction site [polypeptide binding]; other site 471852011071 PHB binding site; other site 471852011072 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 471852011073 active site 471852011074 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 471852011075 nucleophile elbow; other site 471852011076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 471852011077 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins...; Region: Band_7_flotillin; cd03399 471852011078 ATPase involved in DNA repair; Region: DUF3686; pfam12458 471852011079 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 471852011080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852011081 Walker A motif; other site 471852011082 ATP binding site [chemical binding]; other site 471852011083 Walker B motif; other site 471852011084 arginine finger; other site 471852011085 Domain of unknown function (DUF74); Region: DUF74; cl00426 471852011086 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852011087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852011088 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471852011089 dimerization interface [polypeptide binding]; other site 471852011090 putative DNA binding site [nucleotide binding]; other site 471852011091 putative Zn2+ binding site [ion binding]; other site 471852011092 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 471852011093 hydrogenase 4 subunit B; Validated; Region: PRK06521 471852011094 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471852011095 NADH dehydrogenase; Region: NADHdh; cl00469 471852011096 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl12087 471852011097 hydrogenase 4 subunit F; Validated; Region: PRK06458 471852011098 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471852011099 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 471852011100 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 471852011101 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 471852011102 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852011103 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852011104 active site 471852011105 ATP binding site [chemical binding]; other site 471852011106 substrate binding site [chemical binding]; other site 471852011107 activation loop (A-loop); other site 471852011108 Beta-lactamase; Region: Beta-lactamase; cl01009 471852011109 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 471852011110 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 471852011111 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471852011112 Walker A/P-loop; other site 471852011113 ATP binding site [chemical binding]; other site 471852011114 Q-loop/lid; other site 471852011115 ABC transporter signature motif; other site 471852011116 Walker B; other site 471852011117 D-loop; other site 471852011118 H-loop/switch region; other site 471852011119 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471852011120 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471852011121 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471852011122 Walker A/P-loop; other site 471852011123 ATP binding site [chemical binding]; other site 471852011124 Q-loop/lid; other site 471852011125 ABC transporter signature motif; other site 471852011126 Walker B; other site 471852011127 D-loop; other site 471852011128 H-loop/switch region; other site 471852011129 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471852011130 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471852011131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852011132 putative PBP binding loops; other site 471852011133 ABC-ATPase subunit interface; other site 471852011134 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471852011135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 471852011136 dimer interface [polypeptide binding]; other site 471852011137 conserved gate region; other site 471852011138 putative PBP binding loops; other site 471852011139 ABC-ATPase subunit interface; other site 471852011140 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 471852011141 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471852011142 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 471852011143 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 471852011144 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 471852011145 Cobalt transport protein component CbiN; Region: CbiN; cl00842 471852011146 Cobalt transport protein; Region: CbiQ; cl00463 471852011147 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 471852011148 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 471852011149 Walker A/P-loop; other site 471852011150 ATP binding site [chemical binding]; other site 471852011151 Q-loop/lid; other site 471852011152 ABC transporter signature motif; other site 471852011153 Walker B; other site 471852011154 D-loop; other site 471852011155 H-loop/switch region; other site 471852011156 DinB superfamily; Region: DinB_2; cl00986 471852011157 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 471852011158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852011159 putative substrate translocation pore; other site 471852011160 Histidine kinase; Region: HisKA_3; pfam07730 471852011161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852011162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852011163 active site 471852011164 phosphorylation site [posttranslational modification] 471852011165 intermolecular recognition site; other site 471852011166 dimerization interface [polypeptide binding]; other site 471852011167 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 471852011168 DNA binding residues [nucleotide binding] 471852011169 dimerization interface [polypeptide binding]; other site 471852011170 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471852011171 active site 471852011172 ATP binding site [chemical binding]; other site 471852011173 substrate binding site [chemical binding]; other site 471852011174 activation loop (A-loop); other site 471852011175 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 471852011176 active site 471852011177 enoyl-CoA hydratase; Provisional; Region: PRK06127 471852011178 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 471852011179 substrate binding site [chemical binding]; other site 471852011180 oxyanion hole (OAH) forming residues; other site 471852011181 trimer interface [polypeptide binding]; other site 471852011182 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 471852011183 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471852011184 DNA binding residues [nucleotide binding] 471852011185 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471852011186 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 471852011187 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852011188 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 471852011189 Walker A/P-loop; other site 471852011190 ATP binding site [chemical binding]; other site 471852011191 Q-loop/lid; other site 471852011192 ABC transporter signature motif; other site 471852011193 Walker B; other site 471852011194 D-loop; other site 471852011195 H-loop/switch region; other site 471852011196 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 471852011197 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852011198 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471852011199 Walker A/P-loop; other site 471852011200 ATP binding site [chemical binding]; other site 471852011201 Q-loop/lid; other site 471852011202 ABC transporter signature motif; other site 471852011203 Walker B; other site 471852011204 D-loop; other site 471852011205 H-loop/switch region; other site 471852011206 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 471852011207 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 471852011208 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 471852011209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852011210 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 471852011211 generic binding surface II; other site 471852011212 generic binding surface I; other site 471852011213 transcription termination factor Rho; Provisional; Region: PRK12608 471852011214 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 471852011215 RNA binding site [nucleotide binding]; other site 471852011216 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852011217 Walker A motif; other site 471852011218 ATP binding site [chemical binding]; other site 471852011219 Walker B motif; other site 471852011220 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471852011221 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852011222 active site 471852011223 ATP binding site [chemical binding]; other site 471852011224 substrate binding site [chemical binding]; other site 471852011225 activation loop (A-loop); other site 471852011226 acyl-CoA synthetase; Validated; Region: PRK07798 471852011227 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852011228 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852011229 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 471852011230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852011231 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 471852011232 DNA binding residues [nucleotide binding] 471852011233 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471852011234 YceI-like domain; Region: YceI; cl01001 471852011235 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 471852011236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471852011237 dimer interface [polypeptide binding]; other site 471852011238 phosphorylation site [posttranslational modification] 471852011239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852011240 ATP binding site [chemical binding]; other site 471852011241 Mg2+ binding site [ion binding]; other site 471852011242 G-X-G motif; other site 471852011243 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 471852011244 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 471852011245 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 471852011246 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 471852011247 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 471852011248 NAD(P) binding site [chemical binding]; other site 471852011249 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852011250 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 471852011251 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 471852011252 active site 471852011253 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471852011254 Acyl transferase domain; Region: Acyl_transf_1; cl08282 471852011255 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 471852011256 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 471852011257 putative NADP binding site [chemical binding]; other site 471852011258 active site 471852011259 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852011260 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 471852011261 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471852011262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852011263 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471852011264 putative substrate translocation pore; other site 471852011265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852011266 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 471852011267 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471852011268 active site 471852011269 TDP-binding site; other site 471852011270 acceptor substrate-binding pocket; other site 471852011271 homodimer interface [polypeptide binding]; other site 471852011272 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471852011273 acyl-CoA synthetase; Validated; Region: PRK05850 471852011274 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852011275 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852011276 transcription termination factor Rho; Provisional; Region: PRK12678 471852011277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852011278 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471852011279 Bacterial transcriptional regulator; Region: IclR; pfam01614 471852011280 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 471852011281 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471852011282 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 471852011283 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 471852011284 dinuclear metal binding motif [ion binding]; other site 471852011285 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852011286 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852011287 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 471852011288 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 471852011289 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471852011290 anti sigma factor interaction site; other site 471852011291 regulatory phosphorylation site [posttranslational modification]; other site 471852011292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471852011293 dimer interface [polypeptide binding]; other site 471852011294 phosphorylation site [posttranslational modification] 471852011295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852011296 ATP binding site [chemical binding]; other site 471852011297 Mg2+ binding site [ion binding]; other site 471852011298 G-X-G motif; other site 471852011299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852011300 active site 471852011301 phosphorylation site [posttranslational modification] 471852011302 intermolecular recognition site; other site 471852011303 dimerization interface [polypeptide binding]; other site 471852011304 PAS domain S-box; Region: sensory_box; TIGR00229 471852011305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471852011306 putative active site [active] 471852011307 heme pocket [chemical binding]; other site 471852011308 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 471852011309 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471852011310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852011311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 471852011312 dimer interface [polypeptide binding]; other site 471852011313 phosphorylation site [posttranslational modification] 471852011314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471852011315 ATP binding site [chemical binding]; other site 471852011316 Mg2+ binding site [ion binding]; other site 471852011317 G-X-G motif; other site 471852011318 Response regulator receiver domain; Region: Response_reg; pfam00072 471852011319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 471852011320 active site 471852011321 phosphorylation site [posttranslational modification] 471852011322 intermolecular recognition site; other site 471852011323 dimerization interface [polypeptide binding]; other site 471852011324 PAS domain S-box; Region: sensory_box; TIGR00229 471852011325 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 471852011326 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 471852011327 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471852011328 phosphoenolpyruvate synthase; Validated; Region: PRK06241 471852011329 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 471852011330 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 471852011331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852011332 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852011333 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852011334 Domain of unknown function (DUF397); Region: DUF397; pfam04149 471852011335 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 471852011336 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 471852011337 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852011338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852011339 Fic family protein [Function unknown]; Region: COG3177 471852011340 Fic/DOC family; Region: Fic; cl00960 471852011341 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 471852011342 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 471852011343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 471852011344 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 471852011345 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 471852011346 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 471852011347 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 471852011348 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471852011349 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 471852011350 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 471852011351 DNA binding residues [nucleotide binding] 471852011352 drug binding residues [chemical binding]; other site 471852011353 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 471852011354 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 471852011355 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 471852011356 putative active site [active] 471852011357 putative metal binding site [ion binding]; other site 471852011358 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 471852011359 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 471852011360 putative active site [active] 471852011361 putative metal binding site [ion binding]; other site 471852011362 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471852011363 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471852011364 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471852011365 catalytic residue [active] 471852011366 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471852011367 metal binding site 2 [ion binding]; metal-binding site 471852011368 putative DNA binding helix; other site 471852011369 metal binding site 1 [ion binding]; metal-binding site 471852011370 dimer interface [polypeptide binding]; other site 471852011371 structural Zn2+ binding site [ion binding]; other site 471852011372 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852011373 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471852011374 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 471852011375 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 471852011376 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 471852011377 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 471852011378 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471852011379 putative [Fe4-S4] binding site [ion binding]; other site 471852011380 putative molybdopterin cofactor binding site [chemical binding]; other site 471852011381 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 471852011382 putative molybdopterin cofactor binding site; other site 471852011383 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 471852011384 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 471852011385 iron-sulfur cluster [ion binding]; other site 471852011386 [2Fe-2S] cluster binding site [ion binding]; other site 471852011387 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471852011388 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852011389 Walker A/P-loop; other site 471852011390 ATP binding site [chemical binding]; other site 471852011391 Q-loop/lid; other site 471852011392 ABC transporter signature motif; other site 471852011393 Walker B; other site 471852011394 D-loop; other site 471852011395 H-loop/switch region; other site 471852011396 RDD family; Region: RDD; cl00746 471852011397 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471852011398 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 471852011399 Active site [active] 471852011400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471852011401 putative substrate translocation pore; other site 471852011402 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 471852011403 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 471852011404 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 471852011405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 471852011406 motif II; other site 471852011407 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471852011408 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471852011409 catalytic core [active] 471852011410 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 471852011411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 471852011412 S-adenosylmethionine binding site [chemical binding]; other site 471852011413 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 471852011414 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 471852011415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471852011416 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471852011417 anti sigma factor interaction site; other site 471852011418 regulatory phosphorylation site [posttranslational modification]; other site 471852011419 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852011420 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 471852011421 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471852011422 ATP binding site [chemical binding]; other site 471852011423 ATP binding site [chemical binding]; other site 471852011424 putative Mg++ binding site [ion binding]; other site 471852011425 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 471852011426 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852011427 Putative esterase; Region: Esterase; pfam00756 471852011428 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 471852011429 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852011430 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 471852011431 hexamer interface [polypeptide binding]; other site 471852011432 Walker B motif; other site 471852011433 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 471852011434 Fic family protein [Function unknown]; Region: COG3177 471852011435 acetyl-CoA synthetase; Provisional; Region: PRK00174 471852011436 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 471852011437 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 471852011438 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 471852011439 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 471852011440 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471852011441 Domain of unknown function (DUF309); Region: DUF309; cl00667 471852011442 Colicin V production protein; Region: Colicin_V; cl00567 471852011443 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 471852011444 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 471852011445 putative active site [active] 471852011446 putative CoA binding site [chemical binding]; other site 471852011447 nudix motif; other site 471852011448 metal binding site [ion binding]; metal-binding site 471852011449 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 471852011450 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471852011451 minor groove reading motif; other site 471852011452 helix-hairpin-helix signature motif; other site 471852011453 substrate binding pocket [chemical binding]; other site 471852011454 active site 471852011455 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 471852011456 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471852011457 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471852011458 ligand binding site [chemical binding]; other site 471852011459 flexible hinge region; other site 471852011460 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852011461 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471852011462 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 471852011463 homotrimer interaction site [polypeptide binding]; other site 471852011464 putative active site [active] 471852011465 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 471852011466 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 471852011467 nudix motif; other site 471852011468 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852011469 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471852011470 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 471852011471 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 471852011472 cofactor binding site; other site 471852011473 DNA binding site [nucleotide binding] 471852011474 substrate interaction site [chemical binding]; other site 471852011475 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 471852011476 additional DNA contacts [nucleotide binding]; other site 471852011477 active site 471852011478 zinc binding site [ion binding]; other site 471852011479 DNA intercalation site [nucleotide binding]; other site 471852011480 NgoMIV restriction enzyme; Region: NgoMIV_restric; pfam09015 471852011481 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 471852011482 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 471852011483 dimer interface [polypeptide binding]; other site 471852011484 active site 471852011485 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471852011486 catalytic residues [active] 471852011487 substrate binding site [chemical binding]; other site 471852011488 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 471852011489 recombination protein RecR; Reviewed; Region: recR; PRK00076 471852011490 RecR protein; Region: RecR; pfam02132 471852011491 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 471852011492 putative active site [active] 471852011493 putative metal-binding site [ion binding]; other site 471852011494 tetramer interface [polypeptide binding]; other site 471852011495 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852011496 DNA-binding site [nucleotide binding]; DNA binding site 471852011497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852011498 DNA-binding site [nucleotide binding]; DNA binding site 471852011499 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471852011500 DNA-binding site [nucleotide binding]; DNA binding site 471852011501 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471852011502 CoenzymeA binding site [chemical binding]; other site 471852011503 subunit interaction site [polypeptide binding]; other site 471852011504 PHB binding site; other site 471852011505 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471852011506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852011507 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 471852011508 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 471852011509 putative dimerization interface [polypeptide binding]; other site 471852011510 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 471852011511 DNA binding residues [nucleotide binding] 471852011512 dimer interface [polypeptide binding]; other site 471852011513 aspartate kinase; Reviewed; Region: PRK06635 471852011514 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 471852011515 putative nucleotide binding site [chemical binding]; other site 471852011516 putative catalytic residues [active] 471852011517 putative Mg ion binding site [ion binding]; other site 471852011518 putative aspartate binding site [chemical binding]; other site 471852011519 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 471852011520 putative allosteric regulatory site; other site 471852011521 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 471852011522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852011523 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 471852011524 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 471852011525 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 471852011526 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471852011527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852011528 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471852011529 Walker A motif; other site 471852011530 ATP binding site [chemical binding]; other site 471852011531 Walker B motif; other site 471852011532 arginine finger; other site 471852011533 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 471852011534 active site 471852011535 catalytic triad [active] 471852011536 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471852011537 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 471852011538 NAD(P) binding site [chemical binding]; other site 471852011539 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852011540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852011541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471852011542 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 471852011543 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471852011544 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471852011545 Beta-lactamase; Region: Beta-lactamase; cl01009 471852011546 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471852011547 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852011548 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471852011549 Walker A/P-loop; other site 471852011550 ATP binding site [chemical binding]; other site 471852011551 Q-loop/lid; other site 471852011552 ABC transporter signature motif; other site 471852011553 Walker B; other site 471852011554 D-loop; other site 471852011555 H-loop/switch region; other site 471852011556 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 471852011557 active site 471852011558 catalytic triad [active] 471852011559 oxyanion hole [active] 471852011560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471852011561 non-specific DNA binding site [nucleotide binding]; other site 471852011562 salt bridge; other site 471852011563 sequence-specific DNA binding site [nucleotide binding]; other site 471852011564 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 471852011565 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 471852011566 Domain of unknown function DUF11; Region: DUF11; cl15273 471852011567 Uncharacterized conserved protein [Function unknown]; Region: COG3391 471852011568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471852011569 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 471852011570 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471852011571 putative active site [active] 471852011572 putative metal binding site [ion binding]; other site 471852011573 GatB domain; Region: GatB_Yqey; cl11497 471852011574 Transglycosylase; Region: Transgly; cl07896 471852011575 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471852011576 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 471852011577 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 471852011578 Transcription factor WhiB; Region: Whib; pfam02467 471852011579 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 471852011580 P loop; other site 471852011581 Nucleotide binding site [chemical binding]; other site 471852011582 DTAP/Switch II; other site 471852011583 Switch I; other site 471852011584 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 471852011585 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 471852011586 DTAP/Switch II; other site 471852011587 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471852011588 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 471852011589 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471852011590 catalytic residue [active] 471852011591 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 471852011592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 471852011593 Walker A motif; other site 471852011594 ATP binding site [chemical binding]; other site 471852011595 Walker B motif; other site 471852011596 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 471852011597 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 471852011598 Protein of unknown function (DUF952); Region: DUF952; cl01393 471852011599 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471852011600 active site 471852011601 HIGH motif; other site 471852011602 nucleotide binding site [chemical binding]; other site 471852011603 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471852011604 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 471852011605 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 471852011606 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471852011607 non-specific DNA binding site [nucleotide binding]; other site 471852011608 salt bridge; other site 471852011609 sequence-specific DNA binding site [nucleotide binding]; other site 471852011610 Cupin domain; Region: Cupin_2; cl09118 471852011611 B3/4 domain; Region: B3_4; cl11458 471852011612 EamA-like transporter family; Region: EamA; cl01037 471852011613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471852011614 non-specific DNA binding site [nucleotide binding]; other site 471852011615 salt bridge; other site 471852011616 sequence-specific DNA binding site [nucleotide binding]; other site 471852011617 tetratricopeptide repeat protein; Provisional; Region: PRK11788 471852011618 Bacterial membrane flanked domain; Region: DUF304; cl01348 471852011619 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 471852011620 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 471852011621 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 471852011622 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471852011623 nucleoside/Zn binding site; other site 471852011624 dimer interface [polypeptide binding]; other site 471852011625 catalytic motif [active] 471852011626 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 471852011627 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 471852011628 Walker A motif; other site 471852011629 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 471852011630 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 471852011631 ATP binding site [chemical binding]; other site 471852011632 Walker B motif; other site 471852011633 DNA binding loops [nucleotide binding] 471852011634 putative efflux protein, MATE family; Region: matE; TIGR00797 471852011635 MatE; Region: MatE; cl10513 471852011636 MatE; Region: MatE; cl10513 471852011637 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 471852011638 amidase catalytic site [active] 471852011639 Zn binding residues [ion binding]; other site 471852011640 substrate binding site [chemical binding]; other site 471852011641 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 471852011642 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 471852011643 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 471852011644 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 471852011645 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471852011646 dimer interface [polypeptide binding]; other site 471852011647 ssDNA binding site [nucleotide binding]; other site 471852011648 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471852011649 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 471852011650 endonuclease IV; Provisional; Region: PRK01060 471852011651 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 471852011652 AP (apurinic/apyrimidinic) site pocket; other site 471852011653 DNA interaction; other site 471852011654 Metal-binding active site; metal-binding site 471852011655 Transglycosylase; Region: Transgly; cl07896 471852011656 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471852011657 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 471852011658 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 471852011659 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 471852011660 Myo-inositol-1-phosphate synthase; Region: Inos-1-P_synth; cl00554 471852011661 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 471852011662 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 471852011663 NAD binding site [chemical binding]; other site 471852011664 catalytic Zn binding site [ion binding]; other site 471852011665 substrate binding site [chemical binding]; other site 471852011666 structural Zn binding site [ion binding]; other site 471852011667 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 471852011668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471852011669 Dienelactone hydrolase family; Region: DLH; pfam01738 471852011670 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471852011671 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471852011672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 471852011673 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471852011674 active site 471852011675 ATP binding site [chemical binding]; other site 471852011676 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 471852011677 MviN-like protein; Region: MVIN; pfam03023 471852011678 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 471852011679 putative deacylase active site [active] 471852011680 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 471852011681 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 471852011682 active site 471852011683 NTP binding site [chemical binding]; other site 471852011684 metal binding triad [ion binding]; metal-binding site 471852011685 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 471852011686 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471852011687 Zn2+ binding site [ion binding]; other site 471852011688 Mg2+ binding site [ion binding]; other site 471852011689 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 471852011690 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 471852011691 inhibitor-cofactor binding pocket; inhibition site 471852011692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852011693 catalytic residue [active] 471852011694 H+ Antiporter protein; Region: 2A0121; TIGR00900 471852011695 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471852011696 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 471852011697 hypothetical protein; Validated; Region: PRK07682 471852011698 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471852011699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471852011700 homodimer interface [polypeptide binding]; other site 471852011701 catalytic residue [active] 471852011702 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 471852011703 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471852011704 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 471852011705 ParB-like partition proteins; Region: parB_part; TIGR00180 471852011706 ParB-like nuclease domain; Region: ParBc; cl02129 471852011707 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471852011708 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 471852011709 P-loop; other site 471852011710 Magnesium ion binding site [ion binding]; other site 471852011711 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 471852011712 Magnesium ion binding site [ion binding]; other site 471852011713 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 471852011714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 471852011715 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 471852011716 G-X-X-G motif; other site 471852011717 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 471852011718 RxxxH motif; other site 471852011719 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 471852011720 Domain of unknown function DUF37; Region: DUF37; cl00506 471852011721 Ribonuclease P; Region: Ribonuclease_P; cl00457