-- dump date 20111121_015406 -- class Genbank::CDS -- table cds_note -- id note YP_001305268.1 TIGRFAM: chromosomal replication initiator protein DnaA; PFAM: Chromosomal replication initiator, DnaA C-terminal domain; Chromosomal replication initiator, DnaA; SMART: AAA ATPase YP_001305269.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001305272.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001305273.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001305274.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001305275.1 PFAM: Dinitrogenase iron-molybdenum cofactor biosynthesis protein YP_001305276.1 PFAM: Dinitrogenase iron-molybdenum cofactor biosynthesis protein YP_001305277.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Cobyrinic acid a,c-diamide synthase YP_001305278.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Cobyrinic acid a,c-diamide synthase YP_001305279.1 TIGRFAM: putative delta-1-pyrroline-5-carboxylate dehydrogenase; PFAM: aldehyde dehydrogenase YP_001305281.1 PFAM: basic membrane lipoprotein YP_001305282.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001305283.1 PFAM: inner-membrane translocator YP_001305284.1 PFAM: inner-membrane translocator YP_001305286.1 TIGRFAM: conserved hypothetical integral membrane protein; PFAM: protein of unknown function DUF165 YP_001305287.1 TIGRFAM: degV family protein; PFAM: DegV family protein YP_001305288.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001305289.1 PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase YP_001305290.1 PFAM: PHP C-terminal domain protein; SMART: phosphoesterase PHP domain protein YP_001305291.1 TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase YP_001305292.1 PFAM: Mg2+ transporter protein, CorA family protein YP_001305294.1 PFAM: Radical SAM domain protein YP_001305295.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001305296.1 PFAM: isochorismatase hydrolase YP_001305297.1 PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001305298.1 catalyzes branch migration in Holliday junction intermediates YP_001305299.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001305300.1 TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase, catalytic region YP_001305301.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001305302.1 PFAM: periplasmic binding protein YP_001305303.1 PFAM: transport system permease protein; ABC-3 protein YP_001305304.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001305305.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates YP_001305306.1 PFAM: 6,7-dimethyl-8-ribityllumazine synthase YP_001305307.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate YP_001305308.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001305309.1 TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: CMP/dCMP deaminase, zinc-binding; bifunctional deaminase-reductase domain protein YP_001305310.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer YP_001305311.1 TIGRFAM: SUF system FeS assembly protein, NifU family; PFAM: nitrogen-fixing NifU domain protein YP_001305312.1 TIGRFAM: cysteine desulfurase, SufS subfamily; PFAM: aminotransferase, class V YP_001305313.1 PFAM: SufBD protein YP_001305314.1 TIGRFAM: FeS assembly protein SufB; PFAM: SufBD protein YP_001305315.1 TIGRFAM: FeS assembly ATPase SufC; PFAM: ABC transporter related; SMART: AAA ATPase YP_001305316.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001305317.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001305318.1 PFAM: ribonuclease III YP_001305320.1 PFAM: peptidase U62, modulator of DNA gyrase YP_001305321.1 PFAM: peptidase U62, modulator of DNA gyrase YP_001305322.1 PFAM: alanine racemase domain protein YP_001305324.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_001305325.1 PFAM: ribosomal protein S15 YP_001305326.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001305327.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001305328.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001305329.1 TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease YP_001305333.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001305334.1 PFAM: protein of unknown function DUF161 YP_001305335.1 PFAM: isochorismatase hydrolase YP_001305336.1 TIGRFAM: cation diffusion facilitator family transporter; PFAM: cation efflux protein YP_001305338.1 TIGRFAM: galactose-1-phosphate uridylyltransferase YP_001305339.1 TIGRFAM: glycogen/starch synthase, ADP-glucose type; PFAM: glycosyl transferase, group 1; Starch synthase catalytic domain protein YP_001305340.1 PFAM: beta-lactamase domain protein YP_001305341.1 TIGRFAM: PAS sensor protein; PFAM: sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; ATPase associated with various cellular activities, AAA_5; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; AAA ATPase YP_001305342.1 PFAM: protein of unknown function UPF0047 YP_001305343.1 PFAM: protein of unknown function DUF201; D-alanine--D-alanine ligase domain protein YP_001305344.1 PFAM: cobalamin B12-binding domain protein YP_001305345.1 PFAM: UDP-glucose/GDP-mannose dehydrogenase; NAD/NADP octopine/nopaline dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Ketopantoate reductase ApbA/PanE, N-terminal domain protein YP_001305346.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001305347.1 PFAM: MOFRL domain protein YP_001305348.1 TIGRFAM: NAD+ synthetase; PFAM: NAD+ synthase YP_001305349.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001305350.1 PFAM: GrpE protein YP_001305351.1 TIGRFAM: heat-inducible transcription repressor HrcA; PFAM: Negative regulator of class I heat shock protein YP_001305352.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1 YP_001305353.1 PFAM: 3H domain protein; Helix-turn-helix, type 11 domain protein YP_001305354.1 TIGRFAM: channel protein, hemolysin III family; PFAM: Hly-III family protein YP_001305355.1 PFAM: peptidylprolyl isomerase, FKBP-type YP_001305356.1 PFAM: major facilitator superfamily MFS_1 YP_001305357.1 PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001305358.1 PFAM: peptidase M18, aminopeptidase I; peptidase M20; peptidase M42 family protein YP_001305359.1 PFAM: peptidase M42 family protein YP_001305360.1 TIGRFAM: DNA-directed RNA polymerase, omega subunit; PFAM: RNA polymerase Rpb6 YP_001305361.1 Essential for recycling GMP and indirectly, cGMP YP_001305362.1 PFAM: protein of unknown function DUF370 YP_001305363.1 PFAM: YicC N-terminal domain protein YP_001305364.1 PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase YP_001305365.1 PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding YP_001305366.1 catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA YP_001305367.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001305369.1 catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate YP_001305370.1 PFAM: phosphate acetyl/butaryl transferase YP_001305371.1 catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate YP_001305372.1 PFAM: aminotransferase, class I and II YP_001305373.1 PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes YP_001305374.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001305375.1 PFAM: carbon starvation protein CstA YP_001305376.1 PFAM: response regulator receiver; LytTr DNA-binding region YP_001305377.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase internal region; 5TM Receptors of the LytS-YhcK type, transmembrane region YP_001305379.1 Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases YP_001305380.1 PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain YP_001305381.1 PFAM: amidohydrolase YP_001305382.1 PFAM: amidohydrolase YP_001305383.1 TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001305384.1 PFAM: Stage V sporulation protein S YP_001305385.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides YP_001305386.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001305390.1 PFAM: protein of unknown function DUF151 YP_001305391.1 TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: phospholipid/glycerol acyltransferase YP_001305392.1 Required for the synthesis of the thiazole moiety YP_001305393.1 PFAM: protein of unknown function DUF156 YP_001305394.1 PFAM: NLP/P60 protein YP_001305395.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001305396.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001305397.1 PFAM: regulatory protein, MarR YP_001305398.1 PFAM: alpha-2-macroglobulin domain protein YP_001305400.1 PFAM: protein of unknown function DUF1175 YP_001305401.1 PFAM: iron-containing alcohol dehydrogenase YP_001305403.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region YP_001305404.1 PFAM: Abortive infection protein YP_001305406.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer YP_001305408.1 TIGRFAM: oligoendopeptidase, M3 family; PFAM: peptidase M3A and M3B, thimet/oligopeptidase F YP_001305409.1 TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE; virulence factor MVIN family protein YP_001305410.1 PFAM: aldo/keto reductase YP_001305411.1 PFAM: peptidase M29, aminopeptidase II YP_001305412.1 PFAM: ABC-2 type transporter YP_001305413.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001305414.1 PFAM: ABC-2 type transporter YP_001305415.1 PFAM: Appr-1-p processing domain protein YP_001305416.1 PFAM: AAA ATPase, central domain protein YP_001305417.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; NmrA family protein; Male sterility C-terminal domain YP_001305418.1 PFAM: iron dependent repressor YP_001305419.1 TIGRFAM: phage SPO1 DNA polymerase-related protein; PFAM: Uracil-DNA glycosylase superfamily YP_001305420.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001305422.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_001305423.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001305424.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001305425.1 PFAM: peptidyl-tRNA hydrolase YP_001305427.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001305430.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001305431.1 PFAM: phage integrase family protein; phage integrase domain protein SAM domain protein YP_001305436.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001305438.1 PFAM: S-layer domain protein domain protein YP_001305439.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_001305440.1 TIGRFAM: preprotein translocase, SecG subunit; PFAM: Preprotein translocase SecG subunit YP_001305441.1 PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001305442.1 PFAM: putative RNA methylase YP_001305443.1 PFAM: protein of unknown function DUF190 YP_001305444.1 TIGRFAM: CrcB protein; PFAM: Camphor resistance CrcB protein YP_001305446.1 TIGRFAM: non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; PFAM: Ham1 family protein YP_001305447.1 PFAM: protein of unknown function DUF163 YP_001305448.1 PFAM: protein of unknown function DUF501 YP_001305449.1 PFAM: protein-L-isoaspartate(D-aspartate) O-methyltransferase; conserved hypothetical protein 95; methyltransferase small; ribosomal L11 methyltransferase; Methyltransferase type 11; Methyltransferase type 12 YP_001305450.1 PFAM: Peptidoglycan-binding LysM; peptidase M23B YP_001305452.1 PFAM: protein of unknown function DUF849 YP_001305454.1 TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein YP_001305455.1 PFAM: MaoC domain protein dehydratase YP_001305457.1 PFAM: DNA mismatch repair protein MutS domain protein YP_001305458.1 PFAM: D-Lysine 5,6-aminomutase alpha subunit YP_001305459.1 PFAM: cobalamin B12-binding domain protein YP_001305460.1 PFAM: major facilitator superfamily MFS_1 YP_001305461.1 TIGRFAM: conserved hypothetical integral membrane protein; PFAM: protein of unknown function DUF165 YP_001305462.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis YP_001305463.1 PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001305465.1 TIGRFAM: ATP-dependent metalloprotease FtsH; PFAM: peptidase M41; AAA ATPase, central domain protein; peptidase M41, FtsH extracellular; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001305466.1 TIGRFAM: tRNA(Ile)-lysidine synthetase; PFAM: PP-loop domain protein YP_001305467.1 PFAM: peptidase M20; peptidase M42 family protein YP_001305469.1 PFAM: Bacitracin resistance protein BacA YP_001305470.1 TIGRFAM: imidazolonepropionase; PFAM: amidohydrolase; Amidohydrolase 3 YP_001305471.1 PFAM: protein of unknown function DUF1312 YP_001305472.1 PFAM: Heptaprenyl diphosphate synthase component I YP_001305473.1 TIGRFAM: maf protein; PFAM: Maf family protein YP_001305474.1 PFAM: helix-hairpin-helix motif; DNA repair protein RadC YP_001305477.1 PFAM: glycosyl transferase, family 2 YP_001305478.1 PFAM: glycosyl transferase, family 2 YP_001305483.1 TIGRFAM: carboxyl-terminal protease; PFAM: PDZ/DHR/GLGF domain protein; peptidase S41 YP_001305484.1 PFAM: Methyltransferase type 11; tRNA methyltransferase complex GCD14 subunit YP_001305487.1 PFAM: metal-dependent phosphohydrolase, HD sub domain YP_001305488.1 PFAM: protein of unknown function DUF503 YP_001305489.1 heat shock protein involved in degradation of misfolded proteins YP_001305490.1 TIGRFAM: Sua5/YciO/YrdC/YwlC family protein; PFAM: SUA5 domain protein; SUA5/yciO/yrdC, N-terminal domain YP_001305491.1 PFAM: phospholipase D/Transphosphatidylase YP_001305492.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001305493.1 TIGRFAM: UDP-N-acetylmuramoylalanine--D-glutamate ligase; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein YP_001305494.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine YP_001305495.1 TIGRFAM: methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein YP_001305496.1 TIGRFAM: dimethyladenosine transferase; PFAM: ribosomal RNA adenine methylase transferase YP_001305498.1 PFAM: MECDP-synthase YP_001305500.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_001305501.1 TIGRFAM: glucose-1-phosphate adenylyltransferase, GlgD subunit; PFAM: Nucleotidyl transferase YP_001305502.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_001305503.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001305504.1 TIGRFAM: glutamyl-tRNA(Gln) amidotransferase, C subunit YP_001305505.1 PFAM: carbon storage regulator YP_001305506.1 binds to flagellin and appears to stabilize flagellin during flagella assembly YP_001305507.1 PFAM: alpha/beta hydrolase fold YP_001305508.1 PFAM: Positive regulator of sigma(E), RseC/MucC YP_001305509.1 PFAM: Dak phosphatase YP_001305510.1 PFAM: protein of unknown function DUF322 YP_001305511.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001305512.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001305513.1 TIGRFAM: putative translation initiation factor, aIF-2BI family; eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: initiation factor 2B related YP_001305515.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001305516.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001305518.1 PFAM: GCN5-related N-acetyltransferase YP_001305519.1 PFAM: peptidase M50; SMART: PDZ/DHR/GLGF domain protein YP_001305520.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; response regulator receiver YP_001305521.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001305522.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001305524.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_001305526.1 TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase YP_001305527.1 TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase YP_001305528.1 TIGRFAM: orotate phosphoribosyltransferase; PFAM: phosphoribosyltransferase YP_001305529.1 PFAM: extracellular solute-binding protein, family 1 YP_001305530.1 PFAM: FAD dependent oxidoreductase YP_001305531.1 PFAM: RNA binding S1 domain protein; SMART: Resolvase, RNase H domain protein fold YP_001305532.1 PFAM: CheW domain protein YP_001305533.1 TIGRFAM: primosomal protein N'; PFAM: helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001305534.1 TIGRFAM: putative regulatory protein, FmdB family YP_001305535.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein YP_001305536.1 PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001305537.1 PFAM: biotin/lipoate A/B protein ligase YP_001305541.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_001305542.1 TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; GAF domain protein YP_001305543.1 TIGRFAM: ribosomal subunit interface protein; PFAM: sigma 54 modulation protein/ribosomal protein S30EA YP_001305545.1 PFAM: DegV family protein YP_001305546.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex YP_001305547.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001305548.1 TIGRFAM: ATP synthase F1, gamma subunit; PFAM: H+-transporting two-sector ATPase, gamma subunit YP_001305549.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001305550.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_001305551.1 TIGRFAM: ATP synthase F0, B subunit; PFAM: H+-transporting two-sector ATPase, B/B' subunit YP_001305552.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0 YP_001305553.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001305556.1 PFAM: creatinase; peptidase M24 YP_001305557.1 PFAM: Holliday junction resolvase YqgF; SMART: Resolvase, RNase H domain protein fold YP_001305558.1 TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase, RecJ domain protein; phosphoesterase, DHHA1 YP_001305559.1 PFAM: Hsp33 protein YP_001305560.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein YP_001305561.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_001305562.1 PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region YP_001305563.1 PFAM: putative RNA methylase YP_001305564.1 PFAM: DpmII restriction endonuclease YP_001305565.1 TIGRFAM: DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase YP_001305567.1 carries the fatty acid chain in fatty acid biosynthesis YP_001305568.1 PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein YP_001305569.1 PFAM: histidine triad (HIT) protein YP_001305570.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001305572.1 catalyzes the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins YP_001305575.1 TIGRFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; PFAM: GHMP kinase YP_001305576.1 PFAM: peptidase S16, lon domain protein YP_001305577.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001305578.1 PFAM: MscS Mechanosensitive ion channel YP_001305579.1 PFAM: histidine kinase, HAMP region domain protein; Cache domain protein; chemotaxis sensory transducer YP_001305583.1 TIGRFAM: flagellar hook-associated protein FlgK; PFAM: flagellar basal body rod protein; protein of unknown function DUF1078 domain protein YP_001305584.1 TIGRFAM: flagellar hook-associated protein 3; PFAM: flagellin domain protein YP_001305586.1 PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; CHASE2 domain protein YP_001305590.1 PFAM: GAF domain protein; metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001305591.1 TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: serine dehydratase beta chain YP_001305592.1 TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: serine dehydratase alpha chain YP_001305594.1 PFAM: glycoside hydrolase, family 57; Domain of unknown function DUF1957 YP_001305595.1 TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase YP_001305596.1 TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001305597.1 PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein YP_001305598.1 PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding YP_001305599.1 PFAM: glycosyl transferase, family 4 YP_001305601.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer YP_001305602.1 TIGRFAM: CRISPR-associated protein Cas2; PFAM: protein of unknown function DUF196 YP_001305603.1 TIGRFAM: CRISPR-associated protein Cas1; PFAM: protein of unknown function DUF48 YP_001305604.1 TIGRFAM: CRISPR-associated protein Cas4; PFAM: protein of unknown function DUF83 YP_001305606.1 TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated HD domain protein; PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001305607.1 TIGRFAM: CRISPR-associated protein Cas5 YP_001305610.1 TIGRFAM: CRISPR-associated protein Cas6; PFAM: protein of unknown function DUF57 YP_001305614.1 PFAM: peptidase M48, Ste24p YP_001305615.1 PFAM: polysaccharide biosynthesis protein; virulence factor MVIN family protein YP_001305617.1 PFAM: glycosyl transferase, group 1 YP_001305618.1 PFAM: glycosyl transferase, group 1 YP_001305619.1 PFAM: glycosyl transferase, group 1 YP_001305620.1 PFAM: UDP-N-acetylglucosamine 2-epimerase YP_001305621.1 TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: phosphoribosyltransferase; helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001305622.1 PFAM: SMF family protein YP_001305623.1 PFAM: major facilitator superfamily MFS_1 YP_001305626.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001305627.1 TIGRFAM: cytidyltransferase-related domain; nicotinate (nicotinamide) nucleotide adenylyltransferase; PFAM: cytidylyltransferase YP_001305628.1 PFAM: dihydrouridine synthase, DuS YP_001305629.1 PFAM: polysaccharide deacetylase YP_001305630.1 PFAM: aminotransferase, class I and II; Allinase-like YP_001305631.1 PFAM: 2-phosphosulfolactate phosphatase YP_001305633.1 PFAM: glycosyl transferase, family 51; penicillin-binding protein, transpeptidase YP_001305635.1 PFAM: nucleoside diphosphate kinase YP_001305636.1 PFAM: ABC-2 type transporter YP_001305639.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001305640.1 TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; protein of unknown function DUF201 YP_001305641.1 PFAM: AICARFT/IMPCHase bienzyme, formylation region YP_001305642.1 TIGRFAM: phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein YP_001305643.1 TIGRFAM: amidophosphoribosyltransferase; PFAM: glutamine amidotransferase, class-II; phosphoribosyltransferase YP_001305645.1 PFAM: Pyrrolo-quinoline quinone YP_001305648.1 PFAM: Recombinase YP_001305650.1 PFAM: Cobyrinic acid a,c-diamide synthase YP_001305651.1 PFAM: Resolvase, N-terminal domain; Recombinase YP_001305652.1 PFAM: helix-turn-helix domain protein YP_001305655.1 PFAM: protein of unknown function DUF45 YP_001305656.1 TIGRFAM: type I site-specific deoxyribonuclease, HsdR family; PFAM: type III restriction enzyme, res subunit; protein of unknown function DUF450; SMART: DEAD-like helicases-like YP_001305657.1 PFAM: restriction modification system DNA specificity domain YP_001305659.1 TIGRFAM: type I restriction-modification system, M subunit; PFAM: N-6 DNA methylase YP_001305660.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001305661.1 PFAM: ABC-2 type transporter YP_001305662.1 PFAM: peptidase S41 YP_001305663.1 PFAM: Radical SAM domain protein YP_001305664.1 PFAM: Transcriptional regulator IclR-like YP_001305665.1 PFAM: beta-lactamase domain protein YP_001305666.1 PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase YP_001305667.1 PFAM: Rubredoxin-type Fe(Cys)4 protein YP_001305669.1 PFAM: chemotaxis sensory transducer; Heme NO binding domain protein YP_001305670.1 PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001305671.1 TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase YP_001305672.1 PFAM: UvrD/REP helicase YP_001305677.1 TIGRFAM: galactose-1-phosphate uridylyltransferase; PFAM: galactose-1-phosphate uridyl transferase domain protein YP_001305678.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_001305681.1 PFAM: histone family protein DNA-binding protein YP_001305682.1 PFAM: shikimate kinase YP_001305683.1 PFAM: protein of unknown function UPF0047 YP_001305684.1 PFAM: ferric-uptake regulator YP_001305685.1 PFAM: periplasmic solute binding protein YP_001305686.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001305687.1 PFAM: transport system permease protein; ABC-3 protein YP_001305689.1 TIGRFAM: riboflavin biosynthesis protein RibF; cytidyltransferase-related domain; PFAM: Riboflavin kinase / FAD synthetase; cytidylyltransferase YP_001305690.1 TIGRFAM: endonuclease III; PFAM: helix-hairpin-helix motif; HhH-GPD family protein; SMART: iron-sulfur cluster loop YP_001305691.1 PFAM: DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase YP_001305693.1 PFAM: Xanthine/uracil/vitamin C permease; sulphate transporter YP_001305698.1 PFAM: O-antigen polymerase YP_001305703.1 PFAM: chemotaxis sensory transducer YP_001305706.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001305709.1 PFAM: regulatory protein, TetR YP_001305710.1 PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001305711.1 TIGRFAM: pullulanase, type I; PFAM: glycoside hydrolase, family 13 domain protein; pullanase-associated protein; alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001305712.1 PFAM: response regulator receiver YP_001305713.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_001305714.1 PFAM: conserved hypothetical protein 730 YP_001305715.1 PFAM: protein of unknown function DUF6, transmembrane YP_001305716.1 TIGRFAM: cell shape determining protein, MreB/Mrl family; PFAM: cell shape determining protein MreB/Mrl YP_001305717.1 PFAM: flagellar basal body rod protein; protein of unknown function DUF1078 domain protein YP_001305718.1 TIGRFAM: flagellar basal-body rod protein FlgG; PFAM: flagellar basal body rod protein; protein of unknown function DUF1078 domain protein YP_001305719.1 PFAM: protein of unknown function DUF1703 YP_001305720.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001305721.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; Ectoine/hydroxyectoine ABC transporter, permease protein EhuC; PFAM: binding-protein-dependent transport systems inner membrane component YP_001305722.1 PFAM: extracellular solute-binding protein, family 3; SMART: ionotropic glutamate receptor YP_001305723.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001305724.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_001305725.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001305726.1 PFAM: protein of unknown function DUF177 YP_001305727.1 PFAM: Lytic transglycosylase, catalytic YP_001305728.1 TIGRFAM: flagellar M-ring protein FliF; PFAM: secretory protein YscJ/FliF family protein; Flagellar M-ring C-terminal domain protein YP_001305729.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001305730.1 TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease YP_001305731.1 PFAM: PhoH family protein; SMART: Nucleotide binding protein, PINc YP_001305734.1 Catalyzes the phosphorylation of UMP to UDP YP_001305735.1 PFAM: GTP-binding protein, HSR1-related YP_001305736.1 PFAM: CheC domain protein YP_001305737.1 PFAM: purine or other phosphorylase, family 1 YP_001305738.1 TIGRFAM: D-alanine--D-alanine ligase; PFAM: ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; protein of unknown function DUF201; D-alanine--D-alanine ligase domain protein YP_001305739.1 PFAM: alpha/beta hydrolase fold YP_001305740.1 PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein YP_001305741.1 modulates transcription in response to the NADH/NAD(+) redox state YP_001305742.1 PFAM: ferredoxin; 4Fe-4S ferredoxin, iron-sulfur binding domain protein; iron hydrogenase, small subunit; hydrogenase large subunit domain protein YP_001305743.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit YP_001305744.1 PFAM: NADH dehydrogenase (ubiquinone), 24 kDa subunit YP_001305745.1 PFAM: Stage II sporulation E family protein YP_001305746.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Fe-S cluster domain protein YP_001305749.1 PFAM: response regulator receiver; metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001305750.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein YP_001305751.1 SMART: extracellular solute-binding protein, family 3 YP_001305752.1 PFAM: amidohydrolase; Amidohydrolase 3 YP_001305753.1 TIGRFAM: DNA-directed RNA polymerase, beta' subunit; PFAM: RNA polymerase, alpha subunit; RNA polymerase Rpb1, domain 3; RNA polymerase Rpb1, domain 1; RNA polymerase Rpb1, domain 5; RNA polymerase Rpb1, domain 4; SMART: RNA polymerase I subunit A domain protein YP_001305754.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001305755.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001305756.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001305757.1 PFAM: WbqC-like protein family YP_001305758.1 PFAM: Radical SAM domain protein YP_001305759.1 PFAM: Radical SAM domain protein YP_001305760.1 TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase YP_001305761.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis YP_001305762.1 PFAM: formyl transferase domain protein YP_001305763.1 TIGRFAM: glucose-1-phosphate thymidylyltransferase; PFAM: Nucleotidyl transferase YP_001305764.1 TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain YP_001305765.1 PFAM: glycosyl transferase, group 1 YP_001305766.1 PFAM: flagellin domain protein YP_001305767.1 PFAM: glycosyl transferase, family 2; TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein YP_001305768.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001305769.1 TIGRFAM: replicative DNA helicase; PFAM: DnaB domain protein helicase, N-terminal domain protein; DnaB domain protein helicase, C-terminal domain protein; SMART: AAA ATPase YP_001305771.1 PFAM: protein of unknown function DUF1703 YP_001305772.1 PFAM: protein of unknown function DUF1703 YP_001305773.1 TIGRFAM: putative endoribonuclease L-PSP; PFAM: Endoribonuclease L-PSP YP_001305774.1 PFAM: helix-hairpin-helix motif; HhH-GPD family protein YP_001305775.1 PFAM: major facilitator superfamily MFS_1 YP_001305776.1 TIGRFAM: methylglyoxal synthase; PFAM: MGS domain protein YP_001305777.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase, type 3 YP_001305779.1 TIGRFAM: asparaginyl-tRNA synthetase; PFAM: tRNA synthetase, class II (D, K and N); nucleic acid binding, OB-fold, tRNA/helicase-type YP_001305780.1 PFAM: peptidase M32, carboxypeptidase Taq metallopeptidase YP_001305781.1 PFAM: GCN5-related N-acetyltransferase YP_001305782.1 PFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45 YP_001305783.1 PFAM: protein of unknown function DUF198 YP_001305785.1 PFAM: glycosyl transferase, group 1 YP_001305786.1 PFAM: PfkB domain protein YP_001305787.1 TIGRFAM: DNA polymerase III, beta subunit; PFAM: DNA polymerase III, beta chain YP_001305789.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001305791.1 PFAM: flagellin domain protein YP_001305792.1 PFAM: Radical SAM domain protein YP_001305793.1 PFAM: ApbE family lipoprotein YP_001305794.1 PFAM: conserved hypothetical protein 103 YP_001305795.1 PFAM: Rhomboid family protein YP_001305798.1 PFAM: Peptidoglycan-binding LysM; ErfK/YbiS/YcfS/YnhG family protein YP_001305799.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR YP_001305800.1 TIGRFAM: glycogen debranching enzyme GlgX; PFAM: glycoside hydrolase, family 13 domain protein; alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001305801.1 PFAM: OsmC family protein YP_001305802.1 PFAM: cytochrome c biogenesis protein, transmembrane region YP_001305804.1 TIGRFAM: glutaredoxin-like protein, YruB-family; PFAM: glutaredoxin; glutaredoxin 2 YP_001305805.1 TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001305806.1 TIGRFAM: glutaredoxin-like domain protein YP_001305807.1 PFAM: NUDIX hydrolase YP_001305809.1 PFAM: flagellar protein FliS YP_001305811.1 PFAM: uncharacterised conserved protein UCP033563 YP_001305812.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001305813.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001305814.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001305815.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001305816.1 PFAM: extracellular solute-binding protein, family 5 YP_001305817.1 TIGRFAM: putative methyltransferase; PFAM: conserved hypothetical protein 95 YP_001305818.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001305819.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001305820.1 PFAM: ABC transporter related; Transport-associated OB domain protein; SMART: AAA ATPase YP_001305821.1 PFAM: extracellular solute-binding protein, family 1 YP_001305822.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_001305823.1 PFAM: S-adenosylmethionine decarboxylase related YP_001305824.1 PFAM: helix-turn-helix domain protein; Cupin 2, conserved barrel domain protein YP_001305825.1 PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III YP_001305827.1 PFAM: protein of unknown function DUF554 YP_001305828.1 PFAM: protein of unknown function DUF6, transmembrane YP_001305829.1 PFAM: protein of unknown function UPF0054 YP_001305830.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001305831.1 PFAM: PhoH family protein YP_001305832.1 SMART: Tetratricopeptide domain protein YP_001305833.1 TIGRFAM: LAO/AO transport system ATPase; PFAM: cobalamin synthesis protein, P47K; ArgK protein YP_001305834.1 PFAM: cobalamin B12-binding domain protein YP_001305835.1 PFAM: biotin/lipoyl attachment domain-containing protein YP_001305837.1 PFAM: carboxyl transferase YP_001305838.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase YP_001305839.1 PFAM: cyclic nucleotide-binding YP_001305841.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001305842.1 PFAM: metal-dependent phosphohydrolase, HD sub domain YP_001305843.1 PFAM: Rubrerythrin YP_001305846.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001305847.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001305848.1 PFAM: extracellular solute-binding protein, family 1 YP_001305849.1 PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase YP_001305850.1 TIGRFAM: isoaspartyl dipeptidase; PFAM: amidohydrolase; Amidohydrolase 3 YP_001305851.1 PFAM: Abortive infection protein YP_001305852.1 PFAM: Dinitrogenase iron-molybdenum cofactor biosynthesis protein YP_001305853.1 PFAM: SufBD protein YP_001305854.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001305855.1 PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region YP_001305856.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_001305858.1 TIGRFAM: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; PFAM: ribonucleotide reductase large subunit; Ribonucleotide reductase large subunit, N terminal domain protein YP_001305863.1 PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type YP_001305865.1 PFAM: glycerol-3-phosphate responsive antiterminator YP_001305866.1 TIGRFAM: glycerol kinase; PFAM: carbohydrate kinase, FGGY YP_001305867.1 PFAM: protein of unknown function DUF1667 YP_001305868.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001305869.1 PFAM: FAD dependent oxidoreductase; BFD domain protein [2Fe-2S]-binding domain protein YP_001305870.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein YP_001305871.1 PFAM: flagellin domain protein YP_001305872.1 PFAM: NUDIX hydrolase YP_001305873.1 PFAM: Haloacid dehalogenase domain protein hydrolase YP_001305874.1 PFAM: protein of unknown function DUF123 YP_001305875.1 binds and unfolds substrates as part of the ClpXP protease YP_001305876.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001305877.1 PFAM: CBS domain containing protein; ATP-binding region, ATPase domain protein domain protein YP_001305878.1 TIGRFAM: HflC protein; PFAM: band 7 protein YP_001305879.1 TIGRFAM: HflK protein; PFAM: band 7 protein YP_001305880.1 PFAM: Rubrerythrin; Rubredoxin-type Fe(Cys)4 protein YP_001305882.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001305884.1 PFAM: cell cycle protein YP_001305885.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001305886.1 TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n YP_001305887.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001305888.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif YP_001305889.1 TIGRFAM: preprotein translocase, SecE subunit; PFAM: protein secE/sec61-gamma protein YP_001305890.1 TIGRFAM: transcription termination/antitermination factor NusG; PFAM: transcription antitermination protein NusG; KOW domain protein; SMART: NGN domain protein; KOW (Kyrpides, Ouzounis, Woese) domain protein YP_001305891.1 binds directly to 23S ribosomal RNA YP_001305892.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001305893.1 PFAM: protein of unknown function DUF368 YP_001305894.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein YP_001305895.1 PFAM: dihydrofolate reductase region YP_001305897.1 PFAM: ferredoxin; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein YP_001305898.1 PFAM: RnfA-Nqr electron transport subunit YP_001305899.1 PFAM: RnfA-Nqr electron transport subunit YP_001305900.1 PFAM: FMN-binding domain protein YP_001305901.1 PFAM: NQR2 and RnfD family protein YP_001305902.1 PFAM: Nucleotidyl transferase YP_001305903.1 PFAM: Electron transfer flavoprotein, alpha/beta-subunit-like; Electron transfer flavoprotein, alpha subunit-like YP_001305904.1 PFAM: Electron transfer flavoprotein, alpha/beta-subunit-like YP_001305905.1 PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain YP_001305906.1 PFAM: protein of unknown function DUF342 YP_001305908.1 PFAM: lipopolysaccharide biosynthesis protein YP_001305909.1 PFAM: polysaccharide export protein YP_001305910.1 PFAM: phosphoesterase, RecJ domain protein YP_001305911.1 PFAM: PHP C-terminal domain protein; SMART: phosphoesterase PHP domain protein YP_001305912.1 TIGRFAM: UDP-N-acetylmuramyl-tripeptide synthetase; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein YP_001305914.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001305915.1 PFAM: glycosyl transferase, family 4 YP_001305917.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_001305920.1 TIGRFAM: DNA gyrase, B subunit; PFAM: DNA gyrase, subunit B domain protein; ATP-binding region, ATPase domain protein domain protein; TOPRIM domain protein; DNA topoisomerase, type IIA, subunit B, region 2 domain protein; SMART: DNA topoisomerase II YP_001305922.1 PFAM: aminotransferase, class IV YP_001305923.1 TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: Radical SAM domain protein; Protein of unknown function UPF0004-like; SMART: Elongator protein 3/MiaB/NifB YP_001305924.1 PFAM: CBS domain containing protein YP_001305925.1 PFAM: PfkB domain protein YP_001305930.1 PFAM: Radical SAM domain protein YP_001305931.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; copper-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; Heavy metal transport/detoxification protein; E1-E2 ATPase-associated domain protein YP_001305934.1 PFAM: Heavy metal transport/detoxification protein YP_001305935.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001305937.1 PFAM: ROK family protein YP_001305938.1 PFAM: glycoside hydrolase, family 3 domain protein YP_001305939.1 PFAM: extracellular solute-binding protein, family 1 YP_001305940.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001305941.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001305942.1 PFAM: sugar isomerase (SIS) YP_001305943.1 PFAM: amidohydrolase YP_001305944.1 PFAM: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase YP_001305945.1 PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein YP_001305946.1 PFAM: Precorrin-8X methylmutase CbiC/CobH YP_001305947.1 Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A YP_001305948.1 TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001305949.1 TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit YP_001305950.1 PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001305951.1 TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001305952.1 catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3 YP_001305953.1 PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001305954.1 TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK YP_001305955.1 PFAM: glutamyl-tRNA reductase; Shikimate/quinate 5-dehydrogenase YP_001305956.1 TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase YP_001305957.1 TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4 YP_001305958.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001305960.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_001305961.1 TIGRFAM: cobalamin biosynthesis protein CbiM; PFAM: cobalamin (vitamin B12) biosynthesis CbiM protein YP_001305962.1 TIGRFAM: cobalt transport protein; PFAM: Cobalt transport protein CbiN YP_001305963.1 PFAM: cobalt transport protein YP_001305964.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001305965.1 TIGRFAM: putative ATP binding protein; PFAM: protein of unknown function DUF71, ATP-binding region YP_001305966.1 PFAM: ribonuclease H YP_001305967.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001305969.1 PFAM: LemA family protein YP_001305972.1 PFAM: putative esterase YP_001305974.1 catalyzes the formation of L-tryptophan from indole and L-serine YP_001305975.1 PFAM: phosphate transporter YP_001305977.1 PFAM: nitroreductase YP_001305978.1 PFAM: dihydropteroate synthase, DHPS; homocysteine S-methyltransferase; Methionine synthase, B12-binding module, cap domain protein; cobalamin B12-binding domain protein YP_001305979.1 PFAM: Vitamin B12 dependent methionine synthase, activation region YP_001305980.1 PFAM: methylenetetrahydrofolate reductase YP_001305982.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; protein of unknown function DUF39 YP_001305983.1 PFAM: aspartate/glutamate/uridylate kinase YP_001305984.1 PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001305986.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein YP_001305988.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001305992.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001305993.1 SMART: Tetratricopeptide domain protein YP_001305994.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase, type 3 YP_001305995.1 TIGRFAM: glucose-1-phosphate thymidyltransferase; PFAM: Nucleotidyl transferase YP_001305997.1 PFAM: histidine kinase, HAMP region domain protein; Cache domain protein; chemotaxis sensory transducer YP_001305998.1 TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; SMART: PAS domain containing protein YP_001305999.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306000.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306001.1 PFAM: extracellular solute-binding protein, family 1 YP_001306002.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_001306003.1 PFAM: Hemerythrin HHE cation binding domain protein YP_001306004.1 PFAM: cyclic nucleotide-binding; SMART: regulatory protein, Crp YP_001306005.1 PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III YP_001306006.1 PFAM: CoA-binding domain protein YP_001306007.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein YP_001306008.1 TIGRFAM: phenazine biosynthesis protein PhzF family; PFAM: Phenazine biosynthesis PhzC/PhzF protein YP_001306009.1 PFAM: Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein YP_001306010.1 TIGRFAM: pyrrolidone-carboxylate peptidase; PFAM: peptidase C15, pyroglutamyl peptidase I YP_001306011.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001306012.1 PFAM: glycosidase, PH1107-related YP_001306013.1 PFAM: glycoside hydrolase, family 4 YP_001306014.1 PFAM: regulatory protein, ArsR YP_001306015.1 TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase YP_001306016.1 TIGRFAM: DNA mismatch repair protein MutL; PFAM: DNA mismatch repair protein, C-terminal domain protein; MutL, C-terminal, dimerisation YP_001306017.1 PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001306018.1 TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase YP_001306019.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001306020.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein YP_001306021.1 PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001306024.1 TIGRFAM: RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2 YP_001306025.1 PFAM: protein of unknown function DUF72 YP_001306026.1 PFAM: UvrD/REP helicase YP_001306029.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001306030.1 TIGRFAM: molybdenum cofactor synthesis domain; competence/damage-inducible protein CinA; PFAM: molybdopterin binding domain; CinA domain protein YP_001306031.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001306032.1 TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP C-terminal domain protein YP_001306033.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001306034.1 TIGRFAM: PAS sensor protein; PFAM: Stage II sporulation E family protein; PAS fold-4 domain protein; SMART: protein phosphatase 2C domain protein YP_001306035.1 PFAM: protein of unknown function DUF47 YP_001306036.1 PFAM: phosphate transporter YP_001306040.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein YP_001306041.1 Involved in the incorporation of exogenous aryl acids in the biosynthesis of aromatic amino acids: catalysis of the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. YP_001306042.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; thiamine pyrophosphate enzyme domain protein TPP-binding YP_001306043.1 PFAM: Arsenical pump membrane protein; Citrate transporter YP_001306044.1 PFAM: GTP-binding protein, HSR1-related YP_001306045.1 PFAM: Propanediol utilization protein YP_001306049.1 PFAM: glycoside hydrolase, family 13 domain protein; glycoside hydrolase, family 57 YP_001306050.1 PFAM: NADH-ubiquinone oxidoreductase, chain 4L YP_001306051.1 PFAM: NADH/Ubiquinone/plastoquinone (complex I) YP_001306052.1 PFAM: phosphofructokinase YP_001306053.1 PFAM: iron-containing alcohol dehydrogenase YP_001306054.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001306055.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001306057.1 PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Sel1 domain protein repeat-containing protein; Tetratricopeptide domain protein YP_001306059.1 PFAM: protein of unknown function DUF205 YP_001306061.1 PFAM: UDP-N-acetylglucosamine 2-epimerase YP_001306062.1 PFAM: major facilitator superfamily MFS_1 YP_001306064.1 PFAM: extracellular solute-binding protein, family 1 YP_001306065.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306066.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306068.1 PFAM: GGDEF domain containing protein YP_001306070.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001306071.1 TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein YP_001306072.1 PFAM: sugar fermentation stimulation protein YP_001306073.1 TIGRFAM: redox-active disulfide protein 2 YP_001306074.1 PFAM: permease YP_001306075.1 PFAM: regulatory protein, ArsR YP_001306076.1 TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE YP_001306077.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001306080.1 PFAM: Cobyrinic acid a,c-diamide synthase YP_001306081.1 PFAM: protein of unknown function DUF327 YP_001306082.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_001306083.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001306084.1 PFAM: helicase domain protein; DbpA, RNA-binding domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001306085.1 PFAM: outer membrane chaperone Skp (OmpH) YP_001306086.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001306089.1 PFAM: response regulator receiver YP_001306090.1 PFAM: Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein YP_001306091.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001306092.1 PFAM: protein of unknown function DUF322 YP_001306093.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001306095.1 TIGRFAM: flagellar biosynthetic protein FlhB; PFAM: type III secretion exporter YP_001306096.1 TIGRFAM: flagellar biosynthetic protein FliR; PFAM: type III secretion system inner membrane R protein YP_001306097.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer YP_001306098.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_001306099.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein YP_001306100.1 PFAM: Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase YP_001306101.1 PFAM: cobalbumin biosynthesis enzyme YP_001306103.1 PFAM: cobalamin-5-phosphate synthase CobS YP_001306104.1 TIGRFAM: cobyric acid synthase CobQ; PFAM: Cobyrinic acid a,c-diamide synthase; CobB/CobQ domain protein glutamine amidotransferase YP_001306105.1 TIGRFAM: cobalamin biosynthesis protein CobD; PFAM: cobalamin biosynthesis protein CbiB YP_001306106.1 PFAM: aminotransferase, class I and II YP_001306107.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_001306108.1 PFAM: peptidase S8 and S53, subtilisin, kexin, sedolisin YP_001306112.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_001306113.1 PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001306114.1 TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase, DHPS YP_001306116.1 PFAM: aminotransferase, class V YP_001306118.1 PFAM: CDP-alcohol phosphatidyltransferase YP_001306119.1 PFAM: conserved hypothetical protein 374 YP_001306120.1 PFAM: major facilitator superfamily MFS_1 YP_001306121.1 PFAM: protein of unknown function UPF0027 YP_001306122.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001306123.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306128.1 PFAM: protein of unknown function UPF0118 YP_001306129.1 PFAM: Asparaginase/glutaminase YP_001306130.1 PFAM: Rhomboid family protein YP_001306132.1 PFAM: protein of unknown function DUF218 YP_001306133.1 TIGRFAM: flagellar export protein FliJ YP_001306135.1 TIGRFAM: chromosome segregation protein SMC; PFAM: SMC domain protein; RepA / Rep+ KID repeat-containing protein; SMCs flexible hinge domain protein YP_001306136.1 TIGRFAM: UDP-N-acetylmuramate--alanine ligase; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein YP_001306137.1 PFAM: glycosyl transferase, family 28; Glycosyltransferase 28, C-terminal domain YP_001306138.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001306139.1 PFAM: nitroreductase YP_001306141.1 PFAM: FG-GAP repeat protein YP_001306146.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001306147.1 TIGRFAM: putative DNA helicase; SMART: DEAD-like helicases-like YP_001306150.1 PFAM: peptidase S9, prolyl oligopeptidase active site domain protein; Acetyl xylan esterase YP_001306151.1 PFAM: dihydrodipicolinate reductase YP_001306153.1 PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit YP_001306155.1 PFAM: cobalamin B12-binding domain protein YP_001306156.1 TIGRFAM: hydrolase, TatD family; PFAM: TatD-related deoxyribonuclease YP_001306157.1 TIGRFAM: Holliday junction DNA helicase RuvA; PFAM: helix-hairpin-helix motif; RuvA domain protein; DNA recombination protein RuvA, domain I; SMART: Helix-hairpin-helix DNA-binding, class 1 YP_001306160.1 PFAM: PHP C-terminal domain protein YP_001306161.1 PFAM: ATP-binding region, ATPase domain protein domain protein YP_001306162.1 PFAM: surface antigen (D15); surface antigen variable number repeat protein YP_001306163.1 PFAM: Threonyl/alanyl tRNA synthetase, SAD YP_001306165.1 TIGRFAM: pseudouridine synthase, RluA family; PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001306168.1 TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta YP_001306169.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_001306170.1 PFAM: ribosomal protein L35 YP_001306171.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001306172.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001306173.1 PFAM: thymidylate kinase YP_001306174.1 TIGRFAM: flagellar biosynthetic protein FliQ; PFAM: export protein FliQ, family 3 YP_001306175.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_001306177.1 PFAM: response regulator receiver YP_001306178.1 PFAM: CheW domain protein YP_001306179.1 PFAM: CheW domain protein; ATP-binding region, ATPase domain protein domain protein; Signal transducing histidine kinase, homodimeric; Hpt domain protein; P2 response regulator binding domain protein YP_001306181.1 TIGRFAM: hemolysin A; PFAM: ribosomal RNA methyltransferase RrmJ/FtsJ; RNA-binding S4 domain protein YP_001306183.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001306184.1 SMART: GGDEF domain containing protein YP_001306186.1 PFAM: protein of unknown function DUF58 YP_001306187.1 PFAM: AAA ATPase, central domain protein; ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5 YP_001306189.1 PFAM: cell cycle protein YP_001306190.1 TIGRFAM: putative oxygen-independent coproporphyrinogen III oxidase; PFAM: Radical SAM domain protein; HemN domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001306192.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001306193.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001306194.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001306195.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001306196.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001306197.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001306198.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_001306199.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001306200.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001306201.1 PFAM: Ribosomal protein L25/L23 YP_001306202.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001306203.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001306204.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001306205.1 TIGRFAM: ribosomal protein S3; PFAM: ribosomal protein S3-C-terminal domain protein; KH, type 2 domain protein; Ribosomal protein S3, N-terminal domain; SMART: KH domain protein YP_001306206.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001306207.1 one of the stabilizing components for the large ribosomal subunit YP_001306208.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001306209.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001306210.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001306211.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001306212.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_001306213.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001306214.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001306215.1 binds 5S rRNA along with protein L5 and L25 YP_001306216.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001306217.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001306218.1 late assembly protein YP_001306219.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001306220.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001306221.1 TIGRFAM: methionine aminopeptidase, type I; PFAM: peptidase M24 YP_001306222.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001306223.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_001306224.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001306225.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001306226.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001306227.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001306228.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001306229.1 PFAM: trigger factor, C-terminal domain protein; trigger factor, N-terminal domain YP_001306230.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001306231.1 PFAM: protein of unknown function DUF28 YP_001306233.1 PFAM: MCP methyltransferase, CheR-type YP_001306234.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001306235.1 TIGRFAM: pseudouridine synthase, RluA family; PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001306236.1 TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp YP_001306237.1 TIGRFAM: cysteinyl-tRNA synthetase; PFAM: TM1410 hypothetical-related protein YP_001306240.1 PFAM: glycosyl transferase, group 1 YP_001306244.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001306246.1 PFAM: peptidase M22, glycoprotease YP_001306247.1 This protein performs the mismatch recognition step during the DNA repair process YP_001306248.1 PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001306249.1 PFAM: AMMECR1 domain protein YP_001306252.1 PFAM: phosphoadenosine phosphosulfate reductase; PP-loop domain protein YP_001306253.1 PFAM: protein of unknown function DUF1063 YP_001306254.1 PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type YP_001306255.1 PFAM: carbohydrate kinase, FGGY YP_001306256.1 TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein YP_001306257.1 PFAM: glycoside hydrolase, family 38; glycosyl hydrolase 38 domain protein; Glycoside hydrolase, family 38, central region YP_001306258.1 PFAM: regulatory protein GntR, HTH; periplasmic binding protein/LacI transcriptional regulator YP_001306259.1 PFAM: glycosidase, PH1107-related YP_001306260.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306261.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306262.1 PFAM: coagulation factor 5/8 type domain protein; PKD domain containing protein; glycoside hydrolase, family 85 YP_001306263.1 PFAM: extracellular solute-binding protein, family 1 YP_001306264.1 PFAM: MMPL domain protein YP_001306267.1 PFAM: PHA accumulation regulator DNA-binding protein YP_001306268.1 PFAM: transferase hexapeptide repeat containing protein YP_001306269.1 PFAM: Chromate transporter YP_001306270.1 TIGRFAM: DNA topoisomerase I; PFAM: TOPRIM domain protein; DNA topoisomerase, type IA, central domain protein; DNA topoisomerase, type IA, zn finger domain protein; SMART: DNA topoisomerase I, ATP-binding; DNA topoisomerase I, DNA-binding; Toprim sub domain protein YP_001306271.1 TIGRFAM: metal dependent phophohydrolase; PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type; metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001306272.1 TIGRFAM: alanine racemase; PFAM: alanine racemase domain protein YP_001306273.1 required for 70S ribosome assembly YP_001306274.1 PFAM: protein of unknown function DUF214 YP_001306275.1 TIGRFAM: RNA polymerase sigma factor RpoD; RNA polymerase sigma-70; PFAM: sigma-70 1.1 domain protein; sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; sigma-70 region 1.2 YP_001306276.1 TIGRFAM: DNA primase; PFAM: zinc finger, CHC2-family protein; TOPRIM domain protein; DNA primase catalytic core, N-terminal domain; SMART: Toprim sub domain protein YP_001306277.1 forms a direct contact with the tRNA during translation YP_001306278.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001306280.1 involved in the peptidyltransferase reaction during translation YP_001306281.1 PFAM: protein of unknown function DUF464 YP_001306282.1 PFAM: ribosomal protein L21 YP_001306283.1 PFAM: major facilitator superfamily MFS_1 YP_001306284.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001306285.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity YP_001306286.1 PFAM: Stage V sporulation protein S YP_001306288.1 PFAM: protein of unknown function DUF1385 YP_001306289.1 TIGRFAM: diaminopimelate decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2 YP_001306290.1 TIGRFAM: amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein YP_001306291.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001306292.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001306293.1 PFAM: TGS domain protein; Protein of unknown function DUF933 YP_001306295.1 PFAM: cobalamin B12-binding domain protein; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001306296.1 PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase YP_001306297.1 PFAM: zinc/iron permease YP_001306298.1 PFAM: oxidoreductase domain protein; Oxidoreductase, C-terminal domain YP_001306299.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001306300.1 PFAM: 2-nitropropane dioxygenase, NPD YP_001306301.1 PFAM: protein of unknown function DUF1703 YP_001306308.1 PFAM: sugar transferase YP_001306309.1 PFAM: glycosyl transferase, group 1 YP_001306312.1 PFAM: UDP-glucose/GDP-mannose dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase-like YP_001306313.1 PFAM: glycosyl transferase, family 2 YP_001306314.1 TIGRFAM: glucose-1-phosphate thymidylyltransferase; PFAM: Nucleotidyl transferase YP_001306315.1 TIGRFAM: dTDP-4-dehydrorhamnose 3,5-epimerase; PFAM: dTDP-4-dehydrorhamnose 3,5-epimerase related YP_001306316.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase YP_001306317.1 TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain YP_001306318.1 PFAM: CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase YP_001306319.1 PFAM: polysaccharide biosynthesis protein YP_001306320.1 TIGRFAM: cytidyltransferase-related domain; glycerol-3-phosphate cytidylyltransferase; PFAM: Riboflavin kinase / FAD synthetase; cytidylyltransferase YP_001306326.1 TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain YP_001306328.1 PFAM: metallophosphoesterase YP_001306333.1 PFAM: AAA-4 family protein YP_001306335.1 PFAM: KAP P-loop domain protein YP_001306338.1 PFAM: DUF234 DEXX-box ATPase; ATPase YP_001306343.1 PFAM: peptidase S41 YP_001306345.1 PFAM: Domain of unknown function DUF1814 YP_001306346.1 SMART: AAA ATPase YP_001306349.1 PFAM: protein of unknown function DUF1130 YP_001306352.1 PFAM: Methyltransferase type 11; Methyltransferase type 12 YP_001306353.1 PFAM: protein of unknown function DUF6, transmembrane YP_001306360.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer YP_001306361.1 PFAM: metallophosphoesterase YP_001306362.1 blocks the formation of polar Z-ring septums YP_001306363.1 PFAM: protein of unknown function DUF6, transmembrane YP_001306364.1 TIGRFAM: flagellar basal-body rod protein FlgB; PFAM: flagellar basal body rod protein YP_001306365.1 TIGRFAM: flagellar basal-body rod protein FlgC; PFAM: flagellar basal body rod protein; protein of unknown function DUF1078 domain protein YP_001306366.1 TIGRFAM: flagellar hook-basal body complex subunit FliE; PFAM: flagellar hook-basal body complex protein FliE YP_001306367.1 PFAM: heat shock protein Hsp20 YP_001306368.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001306369.1 PFAM: protein of unknown function DUF74 YP_001306372.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001306373.1 PFAM: regulatory protein GntR, HTH YP_001306374.1 TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase YP_001306375.1 TIGRFAM: 3-oxoacid CoA-transferase, B subunit; PFAM: coenzyme A transferase YP_001306376.1 TIGRFAM: 3-oxoacid CoA-transferase, A subunit; PFAM: coenzyme A transferase YP_001306377.1 PFAM: Alkaline phosphatase YP_001306378.1 TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001306379.1 PFAM: oxidoreductase FAD/NAD(P)-binding domain protein YP_001306380.1 PFAM: PfkB domain protein YP_001306381.1 PFAM: ROK family protein YP_001306383.1 PFAM: Radical SAM domain protein YP_001306384.1 PFAM: chemotaxis sensory transducer YP_001306385.1 PFAM: response regulator receiver YP_001306387.1 PFAM: response regulator receiver YP_001306388.1 PFAM: ATP-binding region, ATPase domain protein domain protein; Hpt domain protein YP_001306390.1 PFAM: MCP methyltransferase, CheR-type YP_001306391.1 PFAM: DNA polymerase III, delta YP_001306395.1 TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme YliG; PFAM: Radical SAM domain protein; Protein of unknown function UPF0004-like; SMART: Elongator protein 3/MiaB/NifB YP_001306396.1 TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase YP_001306397.1 TIGRFAM: 2'-5' RNA ligase; PFAM: Phosphoesterase, HXTX YP_001306398.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001306399.1 PFAM: regulatory protein RecX YP_001306400.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP YP_001306401.1 PFAM: ABC transporter related; TOBE domain protein; Transport-associated OB domain protein; SMART: AAA ATPase YP_001306402.1 TIGRFAM: prevent-host-death family protein YP_001306403.1 PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001306404.1 PFAM: regulatory protein, TetR YP_001306405.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001306406.1 PFAM: RNA binding S1 domain protein YP_001306407.1 PFAM: Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit YP_001306408.1 PFAM: NADH dehydrogenase (ubiquinone), 24 kDa subunit YP_001306409.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit YP_001306411.1 PFAM: NADH dehydrogenase (ubiquinone), 24 kDa subunit YP_001306412.1 TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase-like YP_001306413.1 PFAM: inositol monophosphatase YP_001306414.1 PFAM: penicillin-binding protein, transpeptidase YP_001306415.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001306417.1 PFAM: initiation factor 2B related YP_001306418.1 PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001306419.1 PFAM: GatB/Yqey domain protein YP_001306420.1 PFAM: histone deacetylase superfamily YP_001306421.1 TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase YP_001306422.1 TIGRFAM: anti-anti-sigma factor; PFAM: Sulfate transporter/antisigma-factor antagonist STAS YP_001306423.1 TIGRFAM: LexA repressor; PFAM: peptidase S24, S26A and S26B; LexA DNA-binding domain protein YP_001306425.1 TIGRFAM: DNA gyrase, A subunit; PFAM: DNA gyrase/topoisomerase IV, subunit A; DNA gyrase C-terminal repeat, beta-propeller YP_001306426.1 TIGRFAM: methionyl-tRNA synthetase; methionyl-tRNA synthetase, beta subunit; PFAM: t-RNA-binding domain protein; tRNA synthetase class I (M); Cysteinyl-tRNA synthetase, class Ia-like YP_001306427.1 PFAM: extracellular solute-binding protein, family 5 YP_001306428.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306429.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306430.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001306431.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001306432.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001306433.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001306434.1 PFAM: ferric-uptake regulator YP_001306435.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein YP_001306436.1 PFAM: Rubredoxin-type Fe(Cys)4 protein YP_001306437.1 PFAM: beta-lactamase domain protein; flavodoxin/nitric oxide synthase YP_001306438.1 PFAM: Ferritin, Dps family protein YP_001306439.1 PFAM: Helix-turn-helix, type 11 domain protein YP_001306440.1 TIGRFAM: desulfoferrodoxin; PFAM: Desulfoferrodoxin, ferrous iron-binding region; Desulfoferrodoxin Dfx domain protein YP_001306443.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001306444.1 PFAM: transcriptional regulator PadR family protein YP_001306445.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_001306446.1 PFAM: Peptidoglycan-binding LysM; metallophosphoesterase; 5'-Nucleotidase domain protein YP_001306447.1 PFAM: protein of unknown function DUF1121 YP_001306448.1 modulates transcription in response to the NADH/NAD(+) redox state YP_001306449.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001306450.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_001306451.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_001306453.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001306454.1 PFAM: NADH-ubiquinone oxidoreductase, chain 4L YP_001306455.1 PFAM: NADH/Ubiquinone/plastoquinone (complex I) YP_001306456.1 PFAM: NADH/Ubiquinone/plastoquinone (complex I) YP_001306457.1 PFAM: respiratory-chain NADH dehydrogenase, subunit 1 YP_001306458.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_001306459.1 PFAM: NADH dehydrogenase (ubiquinone), 30 kDa subunit YP_001306460.1 Catalyzes the transfer of electrons from NADH to quinone YP_001306461.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain YP_001306464.1 PFAM: glycoside hydrolase, family 20 YP_001306465.1 PFAM: beta-lactamase domain protein YP_001306466.1 PFAM: transcriptional regulator PadR family protein YP_001306467.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region YP_001306468.1 PFAM: transferase hexapeptide repeat containing protein YP_001306469.1 PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit YP_001306470.1 TIGRFAM: phosphoribosylaminoimidazole carboxylase, catalytic subunit; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase YP_001306471.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001306472.1 TIGRFAM: phosphoribosylformylglycinamidine synthase, purS; PFAM: phosphoribosylformylglycinamidine synthetase PurS YP_001306473.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001306474.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001306477.1 PFAM: Indigoidine synthase A family protein YP_001306478.1 TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase YP_001306479.1 PFAM: protein of unknown function UPF0029 YP_001306480.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_001306481.1 TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase YP_001306482.1 PFAM: regulatory protein, MarR; regulatory protein, ArsR YP_001306483.1 TIGRFAM: cation diffusion facilitator family transporter; PFAM: cation efflux protein YP_001306490.1 PFAM: Secretin/TonB, short N-terminal domain YP_001306492.1 PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein YP_001306493.1 PFAM: aminotransferase, class I and II YP_001306494.1 PFAM: cation transporter YP_001306495.1 PFAM: TrkA-N domain protein; TrkA-C domain protein YP_001306496.1 PFAM: TrkA-N domain protein YP_001306497.1 PFAM: response regulator receiver YP_001306498.1 PFAM: triosephosphate isomerase YP_001306499.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001306500.1 TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase YP_001306503.1 TIGRFAM: ATPase, FliI/YscN family; flagellar protein export ATPase FliI; PFAM: H+-transporting two-sector ATPase, alpha/beta subunit, central region; H+-transporting two-sector ATPase, alpha/beta subunit domain protein; SMART: AAA ATPase YP_001306505.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_001306506.1 TIGRFAM: ketose-bisphosphate aldolase; fructose-1,6-bisphosphate aldolase, class II; PFAM: ketose-bisphosphate aldolase, class-II YP_001306508.1 PFAM: cell division protein FtsA YP_001306509.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001306510.1 PFAM: type II secretion system protein E; General secretory system II, protein E domain protein; SMART: AAA ATPase YP_001306512.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001306513.1 TIGRFAM: undecaprenyl diphosphate synthase; PFAM: Di-trans-poly-cis-decaprenylcistransferase YP_001306514.1 PFAM: phosphatidate cytidylyltransferase YP_001306515.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001306516.1 TIGRFAM: cell shape determining protein, MreB/Mrl family; PFAM: cell shape determining protein MreB/Mrl YP_001306518.1 PFAM: GGDEF domain containing protein YP_001306519.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001306520.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain YP_001306523.1 TIGRFAM: translation elongation factor G; small GTP-binding protein; PFAM: elongation factor G domain protein; protein synthesis factor, GTP-binding; elongation factor Tu, domain 2 protein; elongation factor G, domain IV YP_001306526.1 PFAM: flagellar hook capping protein YP_001306527.1 PFAM: flagellar basal body rod protein; protein of unknown function DUF1078 domain protein; flagellar basal body FlaE domain protein YP_001306528.1 PFAM: flagellar FlbD family protein YP_001306529.1 PFAM: MotA/TolQ/ExbB proton channel YP_001306531.1 PFAM: flagellar basal body-associated protein FliL YP_001306532.1 PFAM: surface presentation of antigens (SPOA) protein; flagellar motor switch protein FliM YP_001306533.1 TIGRFAM: flagellar motor switch protein FliN; PFAM: surface presentation of antigens (SPOA) protein; CheC domain protein YP_001306534.1 PFAM: sodium:neurotransmitter symporter YP_001306535.1 PFAM: ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001306536.1 PFAM: chromosome segregation and condensation protein ScpB YP_001306537.1 PFAM: chromosome segregation and condensation protein ScpA YP_001306538.1 PFAM: CBS domain containing protein; amino acid-binding ACT domain protein YP_001306540.1 TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; PFAM: flavoprotein; DNA/pantothenate metabolism flavoprotein domain protein YP_001306541.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_001306542.1 PFAM: beta-lactamase domain protein YP_001306543.1 PFAM: polysaccharide pyruvyl transferase YP_001306544.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001306545.1 PFAM: Lytic transglycosylase, catalytic YP_001306546.1 PFAM: acid phosphatase/vanadium-dependent haloperoxidase related YP_001306548.1 PFAM: protein of unknown function DUF208 YP_001306549.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_001306550.1 TIGRFAM: RelA/SpoT family protein; PFAM: TGS domain protein; metal-dependent phosphohydrolase, HD sub domain; RelA/SpoT domain protein; SMART: metal-dependent phosphohydrolase, HD region YP_001306552.1 PFAM: peptidase C1A, papain YP_001306553.1 PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding YP_001306554.1 PFAM: ferredoxin; [2Fe-2S]-binding domain protein YP_001306555.1 PFAM: molybdopterin dehydrogenase, FAD-binding YP_001306556.1 PFAM: molybdopterin dehydrogenase, FAD-binding; CO dehydrogenase flavoprotein domain protein YP_001306557.1 PFAM: ferredoxin; [2Fe-2S]-binding domain protein YP_001306558.1 TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit YP_001306559.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001306561.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_001306562.1 PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001306563.1 PFAM: protein of unknown function DUF107 YP_001306564.1 PFAM: band 7 protein YP_001306567.1 PFAM: Orn/DAP/Arg decarboxylase 2 YP_001306568.1 TIGRFAM: glycosyl transferase, WecB/TagA/CpsF family; PFAM: glycosyl transferase WecB/TagA/CpsF YP_001306569.1 TIGRFAM: methyltransferase GidB; PFAM: glucose inhibited division protein YP_001306570.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001306571.1 PFAM: protein of unknown function DUF124 YP_001306573.1 PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase-like YP_001306574.1 PFAM: phosphoesterase, PA-phosphatase related YP_001306575.1 PFAM: major facilitator superfamily MFS_1 YP_001306576.1 PFAM: peptidase S9, prolyl oligopeptidase active site domain protein YP_001306578.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein YP_001306579.1 PFAM: glycerophosphoryl diester phosphodiesterase YP_001306580.1 TIGRFAM: 8-amino-7-oxononanoate synthase; pyridoxal phosphate-dependent acyltransferase, putative; PFAM: glycine hydroxymethyltransferase; aminotransferase, class I and II; aminotransferase class-III YP_001306581.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001306586.1 TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE YP_001306588.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001306590.1 PFAM: regulatory protein GntR, HTH YP_001306592.1 catalyzes the formation of fumarate from aspartate YP_001306593.1 TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related YP_001306595.1 PFAM: Polyprenyl synthetase YP_001306597.1 TIGRFAM: uridine kinase; PFAM: phosphoribulokinase/uridine kinase YP_001306598.1 PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001306599.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_001306600.1 PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001306601.1 PFAM: peptidase M50 YP_001306604.1 TIGRFAM: glutamate racemase; PFAM: Asp/Glu racemase YP_001306605.1 PFAM: uncharacterised P-loop ATPase protein UPF0042 YP_001306606.1 PFAM: protein of unknown function UPF0052 and CofD YP_001306607.1 PFAM: protein of unknown function DUF199 YP_001306608.1 PFAM: ATP-cone domain protein YP_001306609.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001306610.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001306612.1 PFAM: RNA-binding S4 domain protein YP_001306614.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001306616.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001306617.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001306618.1 PFAM: extracellular solute-binding protein, family 5 YP_001306619.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306620.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306624.1 PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein YP_001306625.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001306626.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_001306627.1 TIGRFAM: peptide chain release factor 1; PFAM: Class I peptide chain release factor; PCRF domain protein YP_001306628.1 TIGRFAM: twitching motility protein; PFAM: type II secretion system protein E; SMART: AAA ATPase YP_001306629.1 TIGRFAM: DNA polymerase III, subunits gamma and tau; PFAM: AAA ATPase, central domain protein; SMART: AAA ATPase YP_001306630.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001306633.1 PFAM: Patatin YP_001306634.1 TIGRFAM: apurinic endonuclease Apn1; PFAM: Xylose isomerase domain protein TIM barrel; SMART: AP endonuclease, family 2 YP_001306635.1 PFAM: protein of unknown function DUF1622 YP_001306636.1 NH(3)-dependent; catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_001306638.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001306640.1 PFAM: prolipoprotein diacylglyceryl transferase YP_001306641.1 catalyzes the interconversion of 3-phosphoglycerate and 2-phosphoglycerate; this enzyme does not require the cofactor 2,3-bisphosphoglycerate as a phosphate donor; BPG-independent PGAM; aPGAM YP_001306642.1 PFAM: ComEC/Rec2-related protein YP_001306643.1 PFAM: ferric-uptake regulator YP_001306644.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001306645.1 PFAM: protein of unknown function DUF150 YP_001306646.1 PFAM: protein of unknown function DUF861, cupin_3 YP_001306647.1 PFAM: Formiminotransferase-cyclodeaminase YP_001306648.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001306650.1 PFAM: phosphoribosyltransferase YP_001306651.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001306652.1 PFAM: protein of unknown function DUF59 YP_001306653.1 TIGRFAM: modification methylase, HemK family YP_001306654.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001306655.1 PFAM: beta-lactamase domain protein YP_001306656.1 PFAM: metallophosphoesterase YP_001306657.1 PFAM: CBS domain containing protein; phosphoesterase, RecJ domain protein; Polynucleotide adenylyltransferase region; phosphoesterase, DHHA1 YP_001306663.1 TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; RNA polymerase sigma-70; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2 YP_001306664.1 catalyzes the conversion of glutamine residues to glutamate on methyl-accepting chemotaxis receptors YP_001306665.1 PFAM: CheC domain protein YP_001306666.1 PFAM: type IV pilus assembly PilZ YP_001306668.1 PFAM: Cobyrinic acid a,c-diamide synthase YP_001306669.1 positive regulator of class III flagellar genes YP_001306670.1 TIGRFAM: flagellar biosynthesis protein FlhA; PFAM: type III secretion FHIPEP protein YP_001306678.1 PFAM: Fibronectin, type III domain protein YP_001306681.1 TIGRFAM: phage tail tape measure protein, TP901 family YP_001306694.1 PFAM: protein of unknown function DUF264 YP_001306697.1 PFAM: protein of unknown function DUF88 YP_001306703.1 PFAM: regulatory protein, Crp YP_001306704.1 PFAM: RecT protein YP_001306710.1 PFAM: helix-turn-helix domain protein YP_001306711.1 PFAM: helix-turn-helix domain protein; peptidase S24, S26A and S26B YP_001306712.1 PFAM: DNA methylase N-4/N-6 domain protein YP_001306718.1 PFAM: Resolvase, N-terminal domain; Recombinase YP_001306719.1 PFAM: protein of unknown function DUF81 YP_001306720.1 PFAM: PSP1 domain protein YP_001306722.1 PFAM: protein of unknown function UPF0079 YP_001306723.1 TIGRFAM: ATP-dependent protease La; PFAM: peptidase S16, lon domain protein; AAA ATPase, central domain protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001306724.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_001306725.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001306726.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein YP_001306727.1 PFAM: metal-dependent phosphohydrolase, HD sub domain; Metal-dependent hydrolase HDOD YP_001306728.1 PFAM: ribosome-binding factor A YP_001306729.1 PFAM: flagellar protein FlaG protein YP_001306730.1 PFAM: flagellar hook-associated protein 2 domain protein; flagellar hook-associated 2 domain protein; flagellin hook IN repeat protein YP_001306731.1 PFAM: von Willebrand factor, type A YP_001306733.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_001306734.1 PFAM: PASTA domain containing protein YP_001306735.1 TIGRFAM: ribosome small subunit-dependent GTPase A; PFAM: GTPase EngC YP_001306736.1 PFAM: Radical SAM domain protein; Radical SAM N-terminal domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001306737.1 PFAM: CBS domain containing protein; protein of unknown function DUF21; transporter-associated region YP_001306738.1 TIGRFAM: cytidine deaminase; PFAM: CMP/dCMP deaminase, zinc-binding YP_001306739.1 PFAM: SMC domain protein YP_001306741.1 TIGRFAM: DNA ligase, NAD-dependent; PFAM: BRCT domain protein; zinc-finger, NAD-dependent DNA ligase C4-type; NAD-dependent DNA ligase, OB-fold; NAD-dependent DNA ligase, adenylation; SMART: Helix-hairpin-helix DNA-binding, class 1; NAD-dependent DNA ligase-like YP_001306743.1 TIGRFAM: VacB and RNase II family 3'-5' exoribonuclease; ribonuclease R; PFAM: ribonuclease II; RNA binding S1 domain protein; Ribonuclease B, OB region N-terminal domain YP_001306744.1 PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44 YP_001306745.1 PFAM: peptidase, membrane zinc metallopeptidase, putative YP_001306746.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001306747.1 TIGRFAM: RNA methyltransferase, TrmH family, group 3; PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase, substrate binding YP_001306748.1 TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase YP_001306749.1 PFAM: protein of unknown function UPF0118 YP_001306754.1 PFAM: DNA polymerase III, alpha subunit YP_001306755.1 PFAM: ribulose-phosphate 3-epimerase YP_001306756.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_001306757.1 PFAM: phosphoesterase, RecJ domain protein; phosphoesterase, DHHA1 YP_001306758.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein YP_001306759.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001306760.1 catalyzes the removal of amino acids from the N termini of peptides YP_001306761.1 PFAM: regulatory protein, MarR; transcriptional regulator TrmB YP_001306762.1 PFAM: PEGA domain protein YP_001306764.1 PFAM: protein of unknown function DUF342 YP_001306765.1 PFAM: mannose-6-phosphate isomerase, type I YP_001306766.1 PFAM: protein of unknown function DUF89 YP_001306767.1 PFAM: phosphopantetheine-binding YP_001306768.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001306769.1 PFAM: alanine racemase domain protein YP_001306770.1 PFAM: protein of unknown function YGGT YP_001306771.1 catalyzes the phosphorylation of NAD to NADP YP_001306772.1 PFAM: PhoU family protein YP_001306773.1 PFAM: permease YjgP/YjgQ family protein YP_001306774.1 TIGRFAM: RNA methyltransferase, TrmA family; PFAM: deoxyribonuclease/rho motif-related TRAM; protein of unknown function Met10; (Uracil-5)-methyltransferase YP_001306775.1 PFAM: MGS domain protein YP_001306779.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_001306780.1 TIGRFAM: septum site-determining protein MinD; PFAM: Cobyrinic acid a,c-diamide synthase YP_001306785.1 TIGRFAM: signal recognition particle-docking protein FtsY; PFAM: GTP-binding signal recognition particle SRP54, G- domain; GTP-binding signal recognition particle SRP54, helical bundle; SMART: AAA ATPase YP_001306787.1 PFAM: Peptidoglycan-binding LysM; peptidase M23B; 3D domain protein YP_001306788.1 TIGRFAM: putative transcriptional regulator, Rrf2 family; PFAM: protein of unknown function UPF0074 YP_001306789.1 PFAM: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase YP_001306790.1 TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase YP_001306791.1 TIGRFAM: cell envelope-related function transcriptional attenuator, LytR/CpsA family; PFAM: cell envelope-related transcriptional attenuator YP_001306792.1 PFAM: Endonuclease V YP_001306794.1 TIGRFAM: conserved hypothetical radical SAM protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001306795.1 PFAM: amidohydrolase; Amidohydrolase 3 YP_001306796.1 TIGRFAM: iojap-like protein; PFAM: Iojap-related protein YP_001306797.1 TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein YP_001306798.1 TIGRFAM: valyl-tRNA synthetase YP_001306800.1 TIGRFAM: electron transport complex, RnfABCDGE type, C subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit YP_001306801.1 TIGRFAM: electron transport complex, RnfABCDGE type, D subunit; PFAM: NQR2 and RnfD family protein YP_001306802.1 TIGRFAM: electron transport complex, RnfABCDGE type, G subunit YP_001306803.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_001306804.1 TIGRFAM: electron transport complex, RnfABCDGE type, A subunit; PFAM: RnfA-Nqr electron transport subunit YP_001306805.1 PFAM: Arsenical pump membrane protein; Citrate transporter YP_001306806.1 TIGRFAM: Na+/Ca+ antiporter, CaCA family; PFAM: sodium/calcium exchanger membrane region YP_001306807.1 TIGRFAM: inosine-5'-monophosphate dehydrogenase; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase YP_001306808.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; Cache, type 2 domain protein YP_001306809.1 PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001306810.1 PFAM: Methyltransferase type 11; Methyltransferase type 12 YP_001306811.1 catalyzes the formation of L-aspartate to iminoaspartate in NAD(+) biosynthesis YP_001306812.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_001306813.1 TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase YP_001306814.1 PFAM: Beta-ketoacyl synthase-like YP_001306815.1 PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ YP_001306816.1 PFAM: 2-nitropropane dioxygenase, NPD YP_001306817.1 PFAM: BioY protein YP_001306818.1 PFAM: Acyl transferase YP_001306819.1 in Methanocaldococcus jannaschii this enzyme is involved in conversion of 5-phospho-D-ribose-1-pyrophosphate to ribulose-1,5-bisphosphate using NAD as a cofactor; part of RubisCO pathway YP_001306821.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_001306822.1 PFAM: Xylose isomerase domain protein TIM barrel YP_001306823.1 PFAM: Phosphomethylpyrimidine kinase type-1 YP_001306824.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_001306825.1 PFAM: amidohydrolase; Amidohydrolase 3 YP_001306826.1 catalyzes the formation of biotin from dethiobiotin and sulfur YP_001306828.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and IscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; in Thermotoga this enzyme has an extra C-terminal domain YP_001306830.1 TIGRFAM: hydrogenase, Fe-only; PFAM: ferredoxin; 4Fe-4S ferredoxin, iron-sulfur binding domain protein; iron hydrogenase, small subunit; hydrogenase large subunit domain protein YP_001306831.1 PFAM: Auxin Efflux Carrier YP_001306833.1 PFAM: ribonuclease III; double-stranded RNA binding domain protein YP_001306834.1 PFAM: ExsB family protein YP_001306835.1 TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin/lipoate A/B protein ligase YP_001306836.1 TIGRFAM: integral membrane protein MviN; PFAM: multi antimicrobial extrusion protein MatE; virulence factor MVIN family protein YP_001306837.1 PFAM: Fe-S cluster domain protein YP_001306838.1 TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein YP_001306839.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_001306840.1 PFAM: glycoside hydrolase, family 31 YP_001306841.1 PFAM: 3' exoribonuclease; RNA binding S1 domain protein; KH, type 1, domain protein; SMART: KH domain protein YP_001306842.1 PFAM: peptidase M16 domain protein YP_001306843.1 PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001306844.1 heat shock protein involved in degradation of misfolded proteins YP_001306845.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306847.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306848.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_001306849.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001306850.1 TIGRFAM: anti-anti-sigma factor; PFAM: Sulfate transporter/antisigma-factor antagonist STAS YP_001306851.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001306852.1 these proteins appear to have resulted from a fusion of lytB and rpsA; catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_001306853.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001306854.1 PFAM: basic membrane lipoprotein YP_001306856.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001306857.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_001306858.1 TIGRFAM: ribonuclease P protein component; PFAM: ribonuclease P protein YP_001306859.1 PFAM: protein of unknown function DUF37 YP_001306860.1 PFAM: 60 kDa inner membrane insertion protein YP_001306861.1 PFAM: single-stranded nucleic acid binding R3H domain protein YP_001306862.1 PFAM: Cupin 2, conserved barrel domain protein YP_001306863.1 PFAM: TrkA-N domain protein; TrkA-C domain protein; Ion transport 2 domain protein YP_001306864.1 TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp YP_001306865.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; response regulator receiver YP_001306866.1 PFAM: Endonuclease/exonuclease/phosphatase YP_001306867.1 PFAM: glycoside hydrolase, family 1 YP_001306871.1 PFAM: YhhN family protein YP_001306872.1 PFAM: protein of unknown function DUF152 YP_001306874.1 PFAM: glutaredoxin 2 YP_001306875.1 PFAM: protein of unknown function DUF6, transmembrane YP_001306877.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001306879.1 TIGRFAM: CRISPR-associated protein Cas2; PFAM: protein of unknown function DUF196 YP_001306880.1 TIGRFAM: CRISPR-associated protein Cas1; PFAM: protein of unknown function DUF48 YP_001306881.1 TIGRFAM: CRISPR-associated protein Cas2; PFAM: protein of unknown function DUF196 YP_001306885.1 TIGRFAM: putative CRISPR-associated protein, APE2256 family YP_001306886.1 TIGRFAM: CRISPR-associated RAMP protein, Cmr1 family; PFAM: protein of unknown function DUF324 YP_001306887.1 TIGRFAM: CRISPR-associated protein, Crm2 family YP_001306888.1 TIGRFAM: CRISPR-associated protein, Cmr3 family YP_001306889.1 TIGRFAM: CRISPR-associated RAMP protein, Cmr4 family; PFAM: protein of unknown function DUF324 YP_001306890.1 TIGRFAM: CRISPR-associated protein, Cmr5 family YP_001306891.1 TIGRFAM: CRISPR-associated RAMP protein, Cmr6 family; PFAM: protein of unknown function DUF324 YP_001306897.1 TIGRFAM: CRISPR-associated protein, MJ1666 family YP_001306898.1 TIGRFAM: CRISPR-associated protein, Csm1 family; PFAM: metal-dependent phosphohydrolase, HD sub domain YP_001306899.1 TIGRFAM: CRISPR-associated protein, Csm2 family YP_001306900.1 TIGRFAM: CRISPR-associated RAMP protein, Csm3 family; PFAM: protein of unknown function DUF324 YP_001306901.1 TIGRFAM: CRISPR-associated RAMP protein, Csm4 family; PFAM: protein of unknown function DUF324 YP_001306902.1 TIGRFAM: CRISPR-associated RAMP protein, Csm5 family; PFAM: protein of unknown function DUF324 YP_001306904.1 TIGRFAM: CRISPR-associated protein Cas6; PFAM: protein of unknown function DUF57 YP_001306905.1 PFAM: ribonuclease H YP_001306909.1 TIGRFAM: protein-L-isoaspartate O-methyltransferase; PFAM: protein-L-isoaspartate(D-aspartate) O-methyltransferase YP_001306910.1 PFAM: DUF234 DEXX-box ATPase; ATPase YP_001306911.1 PFAM: protein of unknown function DUF262 YP_001306913.1 PFAM: helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001306918.1 PFAM: DNA methylase N-4/N-6 domain protein YP_001306919.1 PFAM: type III restriction enzyme, res subunit YP_001306920.1 PFAM: DNA polymerase, beta domain protein region YP_001306921.1 PFAM: protein of unknown function DUF86 YP_001306923.1 PFAM: Arsenical pump membrane protein; Citrate transporter YP_001306924.1 PFAM: glutaredoxin 2 YP_001306925.1 PFAM: glycosyl transferase, group 1 YP_001306926.1 PFAM: ABC transporter related; Transport-associated OB domain protein; SMART: AAA ATPase YP_001306927.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306928.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306932.1 PFAM: iron-containing alcohol dehydrogenase YP_001306933.1 PFAM: protein of unknown function DUF1291 YP_001306934.1 PFAM: DNA alkylation repair enzyme YP_001306935.1 TIGRFAM: PAS sensor protein; PFAM: Stage II sporulation E family protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; protein phosphatase 2C domain protein YP_001306937.1 PFAM: extracellular solute-binding protein, family 1 YP_001306938.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306939.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306940.1 PFAM: ABC transporter related; Transport-associated OB domain protein; SMART: AAA ATPase YP_001306941.1 PFAM: glycosyl transferase, group 1 YP_001306946.1 PFAM: protein of unknown function DUF81 YP_001306947.1 TIGRFAM: dipeptidase, putative; PFAM: peptidase M20 YP_001306950.1 PFAM: penicillin-binding protein, transpeptidase YP_001306951.1 TIGRFAM: S-adenosyl-methyltransferase MraW; PFAM: methyltransferase YP_001306952.1 PFAM: amidohydrolase YP_001306953.1 PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit YP_001306954.1 PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding YP_001306955.1 TIGRFAM: adenine deaminase; PFAM: amidohydrolase YP_001306956.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001306957.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001306958.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306959.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001306960.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001306962.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_001306963.1 TIGRFAM: ferrous iron transport protein B; small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; Ferrous iron transport protein B domain protein; Ferrous iron transport B domain protein; nucleoside recognition domain protein YP_001306964.1 PFAM: FeoA family protein YP_001306965.1 TIGRFAM: competence protein ComEA helix-hairpin-helix repeat protein; PFAM: helix-hairpin-helix motif; SMART: Helix-hairpin-helix DNA-binding, class 1 YP_001306966.1 PFAM: protein of unknown function DUF52 YP_001306967.1 PFAM: type II and III secretion system protein YP_001306973.1 PFAM: type II secretion system protein YP_001306974.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001306975.1 PFAM: methyltransferase small; Methyltransferase type 12 YP_001306976.1 PFAM: flavin reductase domain protein, FMN-binding YP_001306977.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001306979.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001306980.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001306982.1 PFAM: peptidase M23B YP_001306983.1 TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related YP_001306984.1 TIGRFAM: RNA chaperone Hfq; PFAM: Like-Sm ribonucleoprotein, core YP_001306987.1 PFAM: phosphoribulokinase/uridine kinase YP_001306988.1 TIGRFAM: ribonuclease, Rne/Rng family; PFAM: RNA binding S1 domain protein YP_001306989.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_001306990.1 PFAM: CMP/dCMP deaminase, zinc-binding YP_001306991.1 catalyzes the coenzyme A-dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin YP_001306992.1 TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase YP_001306993.1 PFAM: diacylglycerol kinase YP_001306994.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_001306995.1 PFAM: S-layer domain protein domain protein YP_001306996.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer YP_001306997.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_001306998.1 TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase YP_001307001.1 PFAM: GCN5-related N-acetyltransferase YP_001307002.1 PFAM: metallophosphoesterase YP_001307004.1 PFAM: iron dependent repressor YP_001307005.1 PFAM: peptidase M42 family protein YP_001307010.1 PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein YP_001307011.1 TIGRFAM: tRNA (guanine-N(7)-)-methyltransferase; PFAM: putative methyltransferase YP_001307012.1 PFAM: Tetratricopeptide TPR_2 repeat protein YP_001307013.1 TIGRFAM: carbohydrate kinase, YjeF related protein; PFAM: protein of unknown function UPF0031; YjeF-family N-terminal domain protein YP_001307014.1 PFAM: Lytic transglycosylase, catalytic YP_001307015.1 PFAM: peptidase A24A, prepilin type IV; peptidase A24A domain protein YP_001307016.1 PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_3; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein YP_001307017.1 TIGRFAM: protease Do; PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein YP_001307018.1 TIGRFAM: glycogen/starch/alpha-glucan phosphorylase; PFAM: glycosyl transferase, family 35 YP_001307019.1 TIGRFAM: signal peptidase I; PFAM: peptidase S24, S26A and S26B YP_001307020.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001307022.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001307023.1 TIGRFAM: 16S rRNA processing protein RimM; PFAM: RimM protein; PRC-barrel domain protein YP_001307025.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001307026.1 TIGRFAM: signal recognition particle protein; PFAM: GTP-binding signal recognition particle SRP54, G- domain; Signal peptide binding (SRP54) M- domain protein; GTP-binding signal recognition particle SRP54, helical bundle; SMART: AAA ATPase YP_001307027.1 TIGRFAM: ABC transporter, periplasmic binding protein, thiB subfamily; PFAM: extracellular solute-binding protein, family 1 YP_001307028.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001307029.1 PFAM: Rubrerythrin; protein of unknown function DUF125, transmembrane YP_001307030.1 PFAM: protein of unknown function DUF364 YP_001307031.1 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites YP_001307034.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_001307036.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer YP_001307037.1 PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001307038.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001307039.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001307040.1 PFAM: extracellular solute-binding protein, family 1 YP_001307041.1 PFAM: glycosyl transferase, group 1 YP_001307042.1 PFAM: ROK family protein YP_001307043.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein YP_001307044.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001307045.1 TIGRFAM: phosphate transport system regulatory protein PhoU; PFAM: PhoU family protein YP_001307046.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001307047.1 TIGRFAM: phosphate ABC transporter, inner membrane subunit PstA; PFAM: binding-protein-dependent transport systems inner membrane component YP_001307048.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001307049.1 TIGRFAM: phosphate binding protein; PFAM: extracellular solute-binding protein, family 1 YP_001307050.1 PFAM: aldehyde dehydrogenase YP_001307051.1 PFAM: GCN5-related N-acetyltransferase YP_001307052.1 PFAM: regulatory protein, MarR YP_001307053.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; NmrA family protein; Male sterility C-terminal domain YP_001307054.1 PFAM: PfkB domain protein YP_001307055.1 TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR YP_001307056.1 PFAM: cobalt transport protein YP_001307057.1 pyrophosphate-energized proton pump; pyrophosphate-energized inorganic pyrophosphatase; H+-PPase; can cleave pyrophosphate to two phosphates; can generate a proton motive force and drive pyrophosphate synthesis when PMF is sufficient YP_001307058.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001307059.1 TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; PAS fold domain protein YP_001307060.1 TIGRFAM: pyrimidine-nucleoside phosphorylase; PFAM: glycosyl transferase, family 3; Pyrimidine nucleoside phosphorylase, C-terminal domain YP_001307062.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_001307063.1 catalyzes the formation of D-fructose 6-phosphate from D-glucose 6-phosphate YP_001307065.1 TIGRFAM: dephospho-CoA kinase; PFAM: Dephospho-CoA kinase YP_001307066.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein YP_001307067.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001307068.1 PFAM: protein of unknown function DUF814; Fibronectin-binding A domain protein YP_001307069.1 PFAM: extracellular solute-binding protein, family 5 YP_001307074.1 PFAM: protein of unknown function DUF795 YP_001307075.1 PFAM: helicase domain protein; transcription factor CarD; TRCF domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001307076.1 non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair YP_001307077.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate YP_001307078.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_001307079.1 TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase YP_001307080.1 PFAM: class II aldolase/adducin family protein YP_001307082.1 TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; holo-acyl-carrier-protein synthase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; 4'-phosphopantetheinyl transferase YP_001307083.1 catalyzes the formation of pyruvate from oxaloacetate YP_001307084.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001307086.1 PFAM: chemotaxis sensory transducer YP_001307087.1 PFAM: beta-lactamase domain protein YP_001307088.1 TIGRFAM: conserved hypothetical integral membrane protein; PFAM: protein of unknown function DUF165 YP_001307089.1 PFAM: ATP-citrate lyase/succinyl-CoA ligase; ATP-grasp domain protein YP_001307090.1 PFAM: CoA-binding domain protein; ATP-citrate lyase/succinyl-CoA ligase YP_001307091.1 TIGRFAM: YidE/YbjL duplication; PFAM: YidE/YbjL duplication domain protein YP_001307092.1 TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD - binding; Semialdehyde dehydrogenase, dimerisation region YP_001307093.1 PFAM: diaminopimelate epimerase YP_001307094.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001307095.1 PFAM: dihydrodipicolinate reductase YP_001307096.1 PFAM: transferase hexapeptide repeat containing protein; Tetrahydrodipicolinate succinyltransferase N-terminal domain protein YP_001307097.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_001307098.1 PFAM: aminotransferase class-III YP_001307099.1 PFAM: DegT/DnrJ/EryC1/StrS aminotransferase YP_001307100.1 TIGRFAM: apolipoprotein N-acyltransferase; PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase YP_001307103.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_001307104.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein YP_001307105.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein YP_001307106.1 PFAM: iron-containing alcohol dehydrogenase YP_001307107.1 PFAM: conserved hypothetical protein 95; SMART: PUA domain containing protein YP_001307108.1 SMART: Pyrrolo-quinoline quinone YP_001307109.1 PFAM: NUDIX hydrolase YP_001307110.1 catalyzes the transamination of diaminopimelate with 2-oxoglutarate to produce tetrahydrodipicolinate and glutamate YP_001307111.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_001307112.1 PFAM: transposase IS3/IS911 family protein YP_001307113.1 PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein YP_001307114.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001307115.1 TIGRFAM: sodium ion-translocating decarboxylase, beta subunit; PFAM: Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit YP_001307117.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001307118.1 PFAM: protein of unknown function DUF62 YP_001307119.1 PFAM: phosphofructokinase YP_001307120.1 pyrophosphate-energized proton pump; pyrophosphate-energized inorganic pyrophosphatase; H+-PPase; can cleave pyrophosphate to two phosphates; can generate a proton motive force and drive pyrophosphate synthesis when PMF is sufficient YP_001307121.1 TIGRFAM: protein-export membrane protein, SecD/SecF family; protein-export membrane protein SecF; PFAM: SecD/SecF/SecDF export membrane protein YP_001307122.1 TIGRFAM: protein-export membrane protein, SecD/SecF family; protein-export membrane protein SecD; PFAM: SecD/SecF/SecDF export membrane protein YP_001307123.1 TIGRFAM: preprotein translocase, YajC subunit; PFAM: YajC family protein YP_001307124.1 PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase YP_001307126.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor YP_001307127.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001307130.1 PFAM: Silent information regulator protein Sir2 YP_001307131.1 PFAM: Chromate transporter YP_001307133.1 PFAM: Exonuclease VII, large subunit YP_001307134.1 TIGRFAM: DNA polymerase I; PFAM: DNA-directed DNA polymerase; 5'-3' exonuclease; 3'-5' exonuclease; SMART: Helix-hairpin-helix domain protein, class 2 YP_001307135.1 TIGRFAM: alkylhydroperoxidase like protein, AhpD family; PFAM: Carboxymuconolactone decarboxylase YP_001307136.1 PFAM: cell division protein FtsA YP_001307137.1 TIGRFAM: MutS2 family protein; PFAM: DNA mismatch repair protein MutS domain protein; Smr protein/MutS2; SMART: AAA ATPase; MutS III domain protein YP_001307139.1 PFAM: phosphate transporter YP_001307140.1 PFAM: protein of unknown function DUF47 YP_001307141.1 PFAM: conserved hypothetical protein 374 YP_001307142.1 PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; Nucleotidyl transferase YP_001307143.1 PFAM: helix-turn-helix, Fis-type YP_001307144.1 this enzyme from Pyrococcus has carbamoyl phosphate synthetase activity even though the enzyme shows sequence and structural similarity to carbamate kinase; this enzyme using carbate and ATP to synthesize carbamoyl phosphate which may be a favorable reaction at the extreme temperatures these organisms live under YP_001307145.1 PFAM: phosphate acetyl/butaryl transferase YP_001307146.1 PFAM: peptidase M55, D-aminopeptidase