-- dump date   	20111121_015417
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
688269000001	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14088
688269000002	hypothetical protein; Validated; Region: PRK06672
688269000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269000004	Walker A motif; other site
688269000005	ATP binding site [chemical binding]; other site
688269000006	Walker B motif; other site
688269000007	arginine finger; other site
688269000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
688269000009	DnaA box-binding interface [nucleotide binding]; other site
688269000010	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
688269000011	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269000012	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
688269000013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688269000014	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688269000015	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
688269000016	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
688269000017	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
688269000018	putative substrate binding site [chemical binding]; other site
688269000019	putative ATP binding site [chemical binding]; other site
688269000020	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
688269000021	N-acetyl-D-glucosamine binding site [chemical binding]; other site
688269000022	catalytic residue [active]
688269000023	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
688269000024	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
688269000025	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
688269000026	binding surface
688269000027	TPR motif; other site
688269000028	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
688269000029	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
688269000030	binding surface
688269000031	TPR motif; other site
688269000032	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
688269000033	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
688269000034	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488
688269000035	generic binding surface II; other site
688269000036	ssDNA binding site; other site
688269000037	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
688269000038	ATP binding site [chemical binding]; other site
688269000039	putative Mg++ binding site [ion binding]; other site
688269000040	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688269000041	nucleotide binding region [chemical binding]; other site
688269000042	ATP-binding site [chemical binding]; other site
688269000043	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688269000044	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688269000045	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
688269000046	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269000047	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464
688269000048	putative dimer interface [polypeptide binding]; other site
688269000049	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
688269000050	Clp amino terminal domain; Region: Clp_N; pfam02861
688269000051	Clp amino terminal domain; Region: Clp_N; pfam02861
688269000052	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269000053	Walker A motif; other site
688269000054	ATP binding site [chemical binding]; other site
688269000055	Walker B motif; other site
688269000056	arginine finger; other site
688269000057	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269000058	Walker A motif; other site
688269000059	ATP binding site [chemical binding]; other site
688269000060	Walker B motif; other site
688269000061	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
688269000062	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553
688269000063	NAD synthase; Region: NAD_synthase; pfam02540
688269000064	homodimer interface [polypeptide binding]; other site
688269000065	NAD binding pocket [chemical binding]; other site
688269000066	ATP binding pocket [chemical binding]; other site
688269000067	Mg binding site [ion binding]; other site
688269000068	active-site loop [active]
688269000069	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
688269000070	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
688269000071	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254
688269000072	Walker A/P-loop; other site
688269000073	ATP binding site [chemical binding]; other site
688269000074	Q-loop/lid; other site
688269000075	ABC transporter signature motif; other site
688269000076	Walker B; other site
688269000077	D-loop; other site
688269000078	H-loop/switch region; other site
688269000079	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
688269000080	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
688269000081	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269000082	Walker A/P-loop; other site
688269000083	ATP binding site [chemical binding]; other site
688269000084	Q-loop/lid; other site
688269000085	ABC transporter signature motif; other site
688269000086	Walker B; other site
688269000087	D-loop; other site
688269000088	H-loop/switch region; other site
688269000089	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269000090	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
688269000091	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
688269000092	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
688269000093	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
688269000094	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269000095	dimer interface [polypeptide binding]; other site
688269000096	conserved gate region; other site
688269000097	putative PBP binding loops; other site
688269000098	ABC-ATPase subunit interface; other site
688269000099	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269000100	dimer interface [polypeptide binding]; other site
688269000101	conserved gate region; other site
688269000102	putative PBP binding loops; other site
688269000103	ABC-ATPase subunit interface; other site
688269000104	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
688269000105	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688269000106	Walker A/P-loop; other site
688269000107	ATP binding site [chemical binding]; other site
688269000108	Q-loop/lid; other site
688269000109	ABC transporter signature motif; other site
688269000110	Walker B; other site
688269000111	D-loop; other site
688269000112	H-loop/switch region; other site
688269000113	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688269000114	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688269000115	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
688269000116	Walker A/P-loop; other site
688269000117	ATP binding site [chemical binding]; other site
688269000118	Q-loop/lid; other site
688269000119	ABC transporter signature motif; other site
688269000120	Walker B; other site
688269000121	D-loop; other site
688269000122	H-loop/switch region; other site
688269000123	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688269000124	Beta-lactamase; Region: Beta-lactamase; cl01009
688269000125	Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217
688269000126	hypothetical protein; Provisional; Region: PRK08185
688269000127	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947
688269000128	intersubunit interface [polypeptide binding]; other site
688269000129	active site
688269000130	zinc binding site [ion binding]; other site
688269000131	Na+ binding site [ion binding]; other site
688269000132	Domain of unknown function DUF143; Region: DUF143; cl00519
688269000133	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
688269000134	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714
688269000135	glutaminase active site [active]
688269000136	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
688269000137	dimer interface [polypeptide binding]; other site
688269000138	active site
688269000139	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
688269000140	dimer interface [polypeptide binding]; other site
688269000141	active site
688269000142	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
688269000143	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
688269000144	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
688269000145	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
688269000146	N-acetyl-D-glucosamine binding site [chemical binding]; other site
688269000147	catalytic residue [active]
688269000148	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
688269000149	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
688269000150	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
688269000151	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
688269000152	MgtE intracellular N domain; Region: MgtE_N; cl15244
688269000153	FliG C-terminal domain; Region: FliG_C; pfam01706
688269000154	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
688269000155	putative efflux protein, MATE family; Region: matE; TIGR00797
688269000156	MatE; Region: MatE; cl10513
688269000157	MatE; Region: MatE; cl10513
688269000158	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
688269000159	Domain of unknown function DUF20; Region: UPF0118; cl00465
688269000160	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
688269000161	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
688269000162	Walker A motif; other site
688269000163	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
688269000164	active site
688269000165	Uncharacterized ACR, COG1469; Region: DUF198; cl00642
688269000166	Thymidylate synthase complementing protein; Region: Thy1; cl03630
688269000167	DRTGG domain; Region: DRTGG; cl12147
688269000168	FOG: CBS domain [General function prediction only]; Region: COG0517
688269000169	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205
688269000170	FOG: CBS domain [General function prediction only]; Region: COG0517
688269000171	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
688269000172	DRTGG domain; Region: DRTGG; cl12147
688269000173	PHP domain; Region: PHP; pfam02811
688269000174	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
688269000175	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688269000176	ATP binding site [chemical binding]; other site
688269000177	Mg2+ binding site [ion binding]; other site
688269000178	G-X-G motif; other site
688269000179	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
688269000180	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
688269000181	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
688269000182	Surface antigen; Region: Bac_surface_Ag; cl03097
688269000183	hypothetical protein; Provisional; Region: PRK11820
688269000184	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
688269000185	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
688269000186	Domain of unknown function (DUF370); Region: DUF370; cl00898
688269000187	thymidylate kinase; Region: DTMP_kinase; TIGR00041
688269000188	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071
688269000189	catalytic site [active]
688269000190	G-X2-G-X-G-K; other site
688269000191	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
688269000192	Flavoprotein; Region: Flavoprotein; cl08021
688269000193	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
688269000194	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
688269000195	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
688269000196	putative peptidoglycan binding site; other site
688269000197	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
688269000198	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
688269000199	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692
688269000200	RNA binding site [nucleotide binding]; other site
688269000201	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
688269000202	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
688269000203	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
688269000204	metal-binding site [ion binding]
688269000205	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
688269000206	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688269000207	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
688269000208	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269000209	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
688269000210	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
688269000211	DctM-like transporters; Region: DctM; pfam06808
688269000212	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688269000213	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
688269000214	classical (c) SDRs; Region: SDR_c; cd05233
688269000215	NAD(P) binding site [chemical binding]; other site
688269000216	active site
688269000217	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
688269000218	gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
688269000219	N- and C-terminal domain interface [polypeptide binding]; other site
688269000220	putative active site [active]
688269000221	catalytic site [active]
688269000222	metal binding site [ion binding]; metal-binding site
688269000223	carbohydrate binding site [chemical binding]; other site
688269000224	ATP binding site [chemical binding]; other site
688269000225	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
688269000226	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
688269000227	putative active site [active]
688269000228	serine O-acetyltransferase; Region: cysE; TIGR01172
688269000229	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354
688269000230	trimer interface [polypeptide binding]; other site
688269000231	active site
688269000232	substrate binding site [chemical binding]; other site
688269000233	CoA binding site [chemical binding]; other site
688269000234	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730
688269000235	Rubredoxin; Region: Rubredoxin; pfam00301
688269000236	iron binding site [ion binding]; other site
688269000237	Rubrerythrin [Energy production and conversion]; Region: COG1592
688269000238	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
688269000239	binuclear metal center [ion binding]; other site
688269000240	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and ferredoxin-...; Region: rubredoxin_SM; cd00729
688269000241	iron binding site [ion binding]; other site
688269000242	Sulfatase; Region: Sulfatase; cl10460
688269000243	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
688269000244	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
688269000245	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
688269000246	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cl00258
688269000247	septum formation inhibitor; Provisional; Region: minC; PRK13992
688269000248	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
688269000249	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
688269000250	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
688269000251	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
688269000252	oligomer interface [polypeptide binding]; other site
688269000253	active site
688269000254	metal binding site [ion binding]; metal-binding site
688269000255	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
688269000256	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
688269000257	oligomer interface [polypeptide binding]; other site
688269000258	active site
688269000259	metal binding site [ion binding]; metal-binding site
688269000260	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
688269000261	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
688269000262	oligomer interface [polypeptide binding]; other site
688269000263	active site
688269000264	metal binding site [ion binding]; metal-binding site
688269000265	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
688269000266	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
688269000267	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
688269000268	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
688269000269	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
688269000270	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
688269000271	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
688269000272	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
688269000273	Walker A/P-loop; other site
688269000274	ATP binding site [chemical binding]; other site
688269000275	Q-loop/lid; other site
688269000276	ABC transporter signature motif; other site
688269000277	Walker B; other site
688269000278	D-loop; other site
688269000279	H-loop/switch region; other site
688269000280	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
688269000281	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
688269000282	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
688269000283	active site
688269000284	HIGH motif; other site
688269000285	KMSKS motif; other site
688269000286	dihydrodipicolinate reductase; Provisional; Region: PRK00048
688269000287	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269000288	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
688269000289	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
688269000290	dihydrodipicolinate synthase; Region: dapA; TIGR00674
688269000291	dimer interface [polypeptide binding]; other site
688269000292	active site
688269000293	catalytic residue [active]
688269000294	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
688269000295	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
688269000296	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688269000297	catalytic loop [active]
688269000298	iron binding site [ion binding]; other site
688269000299	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
688269000300	hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512
688269000301	4Fe-4S binding domain; Region: Fer4; cl02805
688269000302	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
688269000303	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503
688269000304	Putative periplasminc binding protein (DUF178); Region: DUF178; cl15271
688269000305	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
688269000306	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269000307	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
688269000308	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293
688269000309	Walker A/P-loop; other site
688269000310	ATP binding site [chemical binding]; other site
688269000311	Q-loop/lid; other site
688269000312	ABC transporter signature motif; other site
688269000313	Walker B; other site
688269000314	D-loop; other site
688269000315	H-loop/switch region; other site
688269000316	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
688269000317	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
688269000318	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269000319	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
688269000320	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
688269000321	hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512
688269000322	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
688269000323	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
688269000324	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503
688269000325	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980
688269000326	dimer interface [polypeptide binding]; other site
688269000327	[2Fe-2S] cluster binding site [ion binding]; other site
688269000328	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980
688269000329	dimer interface [polypeptide binding]; other site
688269000330	[2Fe-2S] cluster binding site [ion binding]; other site
688269000331	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
688269000332	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
688269000333	SLBB domain; Region: SLBB; pfam10531
688269000334	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
688269000335	4Fe-4S binding domain; Region: Fer4; cl02805
688269000336	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
688269000337	4Fe-4S binding domain; Region: Fer4; cl02805
688269000338	NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
688269000339	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064
688269000340	putative dimer interface [polypeptide binding]; other site
688269000341	[2Fe-2S] cluster binding site [ion binding]; other site
688269000342	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
688269000343	hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512
688269000344	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
688269000345	Predicted Fe-S protein [General function prediction only]; Region: COG2000
688269000346	Putative Fe-S cluster; Region: FeS; pfam04060
688269000347	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064
688269000348	putative dimer interface [polypeptide binding]; other site
688269000349	[2Fe-2S] cluster binding site [ion binding]; other site
688269000350	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
688269000351	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
688269000352	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269000353	FeS/SAM binding site; other site
688269000354	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
688269000355	biotin synthase; Provisional; Region: PRK07094
688269000356	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269000357	FeS/SAM binding site; other site
688269000358	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
688269000359	hydrogenase maturation GTPase HydF; Region: GTP_HydF; TIGR03918
688269000360	Era (E. coli Ras-like protein)-like.  This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880
688269000361	G1 box; other site
688269000362	GTP/Mg2+ binding site [chemical binding]; other site
688269000363	Switch I region; other site
688269000364	G2 box; other site
688269000365	Switch II region; other site
688269000366	G3 box; other site
688269000367	G4 box; other site
688269000368	G5 box; other site
688269000369	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
688269000370	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
688269000371	GTP binding site [chemical binding]; other site
688269000372	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
688269000373	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
688269000374	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688269000375	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
688269000376	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
688269000377	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
688269000378	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
688269000379	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
688269000380	dimer interface [polypeptide binding]; other site
688269000381	catalytic triad [active]
688269000382	2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11869
688269000383	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
688269000384	TPP-binding site [chemical binding]; other site
688269000385	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
688269000386	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
688269000387	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
688269000388	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
688269000389	dimer interface [polypeptide binding]; other site
688269000390	PYR/PP interface [polypeptide binding]; other site
688269000391	TPP binding site [chemical binding]; other site
688269000392	substrate binding site [chemical binding]; other site
688269000393	trigger factor; Region: tig; TIGR00115
688269000394	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
688269000395	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
688269000396	oligomer interface [polypeptide binding]; other site
688269000397	active site residues [active]
688269000398	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
688269000399	MutS domain I; Region: MutS_I; pfam01624
688269000400	MutS domain II; Region: MutS_II; pfam05188
688269000401	MutS family domain IV; Region: MutS_IV; pfam05190
688269000402	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
688269000403	Walker A/P-loop; other site
688269000404	ATP binding site [chemical binding]; other site
688269000405	Q-loop/lid; other site
688269000406	ABC transporter signature motif; other site
688269000407	Walker B; other site
688269000408	D-loop; other site
688269000409	H-loop/switch region; other site
688269000410	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
688269000411	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
688269000412	Fe-S cluster binding site [ion binding]; other site
688269000413	active site
688269000414	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
688269000415	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269000416	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
688269000417	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
688269000418	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
688269000419	NAD binding site [chemical binding]; other site
688269000420	substrate binding site [chemical binding]; other site
688269000421	homodimer interface [polypeptide binding]; other site
688269000422	active site
688269000423	recombination factor protein RarA; Reviewed; Region: PRK13342
688269000424	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269000425	Walker A motif; other site
688269000426	ATP binding site [chemical binding]; other site
688269000427	Walker B motif; other site
688269000428	arginine finger; other site
688269000429	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
688269000430	Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023
688269000431	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
688269000432	active site
688269000433	metal binding site [ion binding]; metal-binding site
688269000434	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269000435	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688269000436	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269000437	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269000438	dimer interface [polypeptide binding]; other site
688269000439	conserved gate region; other site
688269000440	putative PBP binding loops; other site
688269000441	ABC-ATPase subunit interface; other site
688269000442	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
688269000443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269000444	dimer interface [polypeptide binding]; other site
688269000445	conserved gate region; other site
688269000446	putative PBP binding loops; other site
688269000447	ABC-ATPase subunit interface; other site
688269000448	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269000449	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
688269000450	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
688269000451	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
688269000452	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
688269000453	Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915
688269000454	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
688269000455	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688269000456	Walker A/P-loop; other site
688269000457	ATP binding site [chemical binding]; other site
688269000458	Q-loop/lid; other site
688269000459	ABC transporter signature motif; other site
688269000460	Walker B; other site
688269000461	D-loop; other site
688269000462	H-loop/switch region; other site
688269000463	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688269000464	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
688269000465	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688269000466	Walker A/P-loop; other site
688269000467	ATP binding site [chemical binding]; other site
688269000468	Q-loop/lid; other site
688269000469	ABC transporter signature motif; other site
688269000470	Walker B; other site
688269000471	D-loop; other site
688269000472	H-loop/switch region; other site
688269000473	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688269000474	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269000475	dimer interface [polypeptide binding]; other site
688269000476	conserved gate region; other site
688269000477	putative PBP binding loops; other site
688269000478	ABC-ATPase subunit interface; other site
688269000479	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
688269000480	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269000481	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
688269000482	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
688269000483	substrate binding site [chemical binding]; other site
688269000484	mannonate dehydratase; Provisional; Region: PRK03906
688269000485	mannonate dehydratase; Region: uxuA; TIGR00695
688269000486	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
688269000487	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
688269000488	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
688269000489	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
688269000490	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
688269000491	NAD binding site [chemical binding]; other site
688269000492	sugar binding site [chemical binding]; other site
688269000493	divalent metal binding site [ion binding]; other site
688269000494	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
688269000495	dimer interface [polypeptide binding]; other site
688269000496	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
688269000497	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
688269000498	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688269000499	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
688269000500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269000501	dimer interface [polypeptide binding]; other site
688269000502	conserved gate region; other site
688269000503	putative PBP binding loops; other site
688269000504	ABC-ATPase subunit interface; other site
688269000505	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
688269000506	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
688269000507	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269000508	dimer interface [polypeptide binding]; other site
688269000509	putative PBP binding loops; other site
688269000510	ABC-ATPase subunit interface; other site
688269000511	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
688269000512	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688269000513	Walker A/P-loop; other site
688269000514	ATP binding site [chemical binding]; other site
688269000515	Q-loop/lid; other site
688269000516	ABC transporter signature motif; other site
688269000517	Walker B; other site
688269000518	D-loop; other site
688269000519	H-loop/switch region; other site
688269000520	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688269000521	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
688269000522	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688269000523	Walker A/P-loop; other site
688269000524	ATP binding site [chemical binding]; other site
688269000525	Q-loop/lid; other site
688269000526	ABC transporter signature motif; other site
688269000527	Walker B; other site
688269000528	D-loop; other site
688269000529	H-loop/switch region; other site
688269000530	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688269000531	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
688269000532	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
688269000533	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
688269000534	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
688269000535	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
688269000536	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
688269000537	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
688269000538	active site
688269000539	catalytic residues [active]
688269000540	xylose isomerase; Region: PLN02923
688269000541	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
688269000542	D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
688269000543	N- and C-terminal domain interface [polypeptide binding]; other site
688269000544	D-xylulose kinase; Region: XylB; TIGR01312
688269000545	active site
688269000546	catalytic site [active]
688269000547	metal binding site [ion binding]; metal-binding site
688269000548	xylulose binding site [chemical binding]; other site
688269000549	putative ATP binding site [chemical binding]; other site
688269000550	homodimer interface [polypeptide binding]; other site
688269000551	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
688269000552	domain; Region: Glyco_hydro_2; pfam00703
688269000553	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
688269000554	Transposase, Mutator family; Region: Transposase_mut; pfam00872
688269000555	MULE transposase domain; Region: MULE; pfam10551
688269000556	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
688269000557	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688269000558	Major Facilitator Superfamily; Region: MFS_1; pfam07690
688269000559	putative substrate translocation pore; other site
688269000560	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
688269000561	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
688269000562	dimerization interface [polypeptide binding]; other site
688269000563	putative ATP binding site [chemical binding]; other site
688269000564	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142
688269000565	putative FMN binding site [chemical binding]; other site
688269000566	NADPH bind site [chemical binding]; other site
688269000567	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017
688269000568	catalytic triad [active]
688269000569	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
688269000570	putative FMN binding site [chemical binding]; other site
688269000571	TRAM domain; Region: TRAM; cl01282
688269000572	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
688269000573	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688269000574	S-adenosylmethionine binding site [chemical binding]; other site
688269000575	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
688269000576	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
688269000577	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269000578	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
688269000579	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
688269000580	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
688269000581	active site
688269000582	dimer interface [polypeptide binding]; other site
688269000583	effector binding site; other site
688269000584	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
688269000585	TSCPD domain; Region: TSCPD; cl14834
688269000586	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
688269000587	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688269000588	DNA-binding site [nucleotide binding]; DNA binding site
688269000589	Protein of unknown function (DUF1292); Region: DUF1292; cl01608
688269000590	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
688269000591	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
688269000592	ligand binding site [chemical binding]; other site
688269000593	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
688269000594	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
688269000595	Walker A/P-loop; other site
688269000596	ATP binding site [chemical binding]; other site
688269000597	Q-loop/lid; other site
688269000598	ABC transporter signature motif; other site
688269000599	Walker B; other site
688269000600	D-loop; other site
688269000601	H-loop/switch region; other site
688269000602	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
688269000603	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
688269000604	TM-ABC transporter signature motif; other site
688269000605	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
688269000606	TM-ABC transporter signature motif; other site
688269000607	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
688269000608	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
688269000609	putative active site [active]
688269000610	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
688269000611	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
688269000612	N- and C-terminal domain interface [polypeptide binding]; other site
688269000613	active site
688269000614	MgATP binding site [chemical binding]; other site
688269000615	catalytic site [active]
688269000616	metal binding site [ion binding]; metal-binding site
688269000617	carbohydrate binding site [chemical binding]; other site
688269000618	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
688269000619	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
688269000620	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
688269000621	anti sigma factor interaction site; other site
688269000622	regulatory phosphorylation site [posttranslational modification]; other site
688269000623	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269000624	LexA repressor; Validated; Region: PRK00215
688269000625	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
688269000626	Catalytic site [active]
688269000627	Archease protein family (DUF101/UPF0211); Region: Archease; cl00606
688269000628	DNA gyrase subunit A; Validated; Region: PRK05560
688269000629	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
688269000630	CAP-like domain; other site
688269000631	Active site [active]
688269000632	primary dimer interface [polypeptide binding]; other site
688269000633	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
688269000634	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
688269000635	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
688269000636	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
688269000637	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
688269000638	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
688269000639	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
688269000640	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
688269000641	active site
688269000642	HIGH motif; other site
688269000643	KMSKS motif; other site
688269000644	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
688269000645	tRNA binding surface [nucleotide binding]; other site
688269000646	anticodon binding site; other site
688269000647	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
688269000648	dimer interface [polypeptide binding]; other site
688269000649	putative tRNA-binding site [nucleotide binding]; other site
688269000650	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
688269000651	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688269000652	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
688269000653	Ion channel; Region: Ion_trans_2; cl11596
688269000654	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269000655	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688269000656	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
688269000657	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688269000658	AIR carboxylase; Region: AIRC; cl00310
688269000659	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
688269000660	ABC-2 type transporter; Region: ABC2_membrane; cl11417
688269000661	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
688269000662	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269000663	Walker A/P-loop; other site
688269000664	ATP binding site [chemical binding]; other site
688269000665	Q-loop/lid; other site
688269000666	ABC transporter signature motif; other site
688269000667	Walker B; other site
688269000668	D-loop; other site
688269000669	H-loop/switch region; other site
688269000670	DctM-like transporters; Region: DctM; pfam06808
688269000671	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688269000672	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
688269000673	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
688269000674	Dehydratase family; Region: ILVD_EDD; cl00340
688269000675	dihydroxy-acid dehydratase; Region: ilvD; TIGR00110
688269000676	ketol-acid reductoisomerase; Provisional; Region: PRK05479
688269000677	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269000678	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
688269000679	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
688269000680	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
688269000681	putative valine binding site [chemical binding]; other site
688269000682	dimer interface [polypeptide binding]; other site
688269000683	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
688269000684	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
688269000685	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
688269000686	PYR/PP interface [polypeptide binding]; other site
688269000687	dimer interface [polypeptide binding]; other site
688269000688	TPP binding site [chemical binding]; other site
688269000689	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
688269000690	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
688269000691	TPP-binding site [chemical binding]; other site
688269000692	dimer interface [polypeptide binding]; other site
688269000693	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
688269000694	isocitrate dehydrogenase; Validated; Region: PRK06451
688269000695	aconitate hydratase; Validated; Region: PRK07229
688269000696	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
688269000697	substrate binding site [chemical binding]; other site
688269000698	ligand binding site [chemical binding]; other site
688269000699	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
688269000700	substrate binding site [chemical binding]; other site
688269000701	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
688269000702	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
688269000703	active site
688269000704	catalytic residues [active]
688269000705	metal binding site [ion binding]; metal-binding site
688269000706	DNA polymerase III PolC; Validated; Region: polC; PRK00448
688269000707	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
688269000708	generic binding surface II; other site
688269000709	generic binding surface I; other site
688269000710	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
688269000711	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
688269000712	active site
688269000713	substrate binding site [chemical binding]; other site
688269000714	catalytic site [active]
688269000715	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
688269000716	Protein of unknown function, DUF655; Region: DUF655; cl00648
688269000717	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
688269000718	active site
688269000719	putative DNA-binding cleft [nucleotide binding]; other site
688269000720	dimer interface [polypeptide binding]; other site
688269000721	GTP-binding protein LepA; Provisional; Region: PRK05433
688269000722	LepA subfamily.  LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome.  LepA is ubiquitous in bacteria and...; Region: LepA; cd01890
688269000723	G1 box; other site
688269000724	putative GEF interaction site [polypeptide binding]; other site
688269000725	GTP/Mg2+ binding site [chemical binding]; other site
688269000726	Switch I region; other site
688269000727	G2 box; other site
688269000728	G3 box; other site
688269000729	Switch II region; other site
688269000730	G4 box; other site
688269000731	G5 box; other site
688269000732	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699
688269000733	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
688269000734	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
688269000735	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
688269000736	homodimer interface [polypeptide binding]; other site
688269000737	homotetramer interface [polypeptide binding]; other site
688269000738	active site pocket [active]
688269000739	cleavage site
688269000740	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
688269000741	dimerization interface [polypeptide binding]; other site
688269000742	putative DNA binding site [nucleotide binding]; other site
688269000743	putative Zn2+ binding site [ion binding]; other site
688269000744	Low molecular weight phosphatase family; Region: LMWPc; cd00115
688269000745	Active site [active]
688269000746	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
688269000747	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
688269000748	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
688269000749	DNA binding site [nucleotide binding]
688269000750	active site
688269000751	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
688269000752	Transglycosylase; Region: Transgly; cl07896
688269000753	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
688269000754	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
688269000755	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780
688269000756	active site
688269000757	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type...; Region: chaperonin_like; cl02777
688269000758	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
688269000759	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066
688269000760	active site
688269000761	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
688269000762	flagellin; Provisional; Region: PRK12802
688269000763	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
688269000764	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
688269000765	oligomer interface [polypeptide binding]; other site
688269000766	putative active site [active]
688269000767	metal binding site [ion binding]; metal-binding site
688269000768	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688269000769	DctM-like transporters; Region: DctM; pfam06808
688269000770	Domain of unknown function (DUF1850); Region: DUF1850; cl01950
688269000771	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
688269000772	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
688269000773	SxDxEG motif; other site
688269000774	active site
688269000775	metal binding site [ion binding]; metal-binding site
688269000776	homopentamer interface [polypeptide binding]; other site
688269000777	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
688269000778	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
688269000779	catalytic triad [active]
688269000780	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
688269000781	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
688269000782	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301
688269000783	active site
688269000784	dimer interface [polypeptide binding]; other site
688269000785	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269000786	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142
688269000787	putative FMN binding site [chemical binding]; other site
688269000788	NADPH bind site [chemical binding]; other site
688269000789	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
688269000790	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271
688269000791	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
688269000792	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
688269000793	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269000794	NAD(P) binding site [chemical binding]; other site
688269000795	active site
688269000796	bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional; Region: pyrB; PRK13376
688269000797	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
688269000798	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269000799	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
688269000800	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
688269000801	Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219
688269000802	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
688269000803	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
688269000804	active site
688269000805	DNA topoisomerase I; Validated; Region: PRK05582
688269000806	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363
688269000807	active site
688269000808	interdomain interaction site; other site
688269000809	putative metal-binding site [ion binding]; other site
688269000810	nucleotide binding site [chemical binding]; other site
688269000811	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
688269000812	domain I; other site
688269000813	DNA binding groove [nucleotide binding]
688269000814	phosphate binding site [ion binding]; other site
688269000815	domain II; other site
688269000816	domain III; other site
688269000817	nucleotide binding site [chemical binding]; other site
688269000818	catalytic site [active]
688269000819	domain IV; other site
688269000820	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
688269000821	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
688269000822	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a...; Region: PGM_like2; cd05800
688269000823	active site
688269000824	substrate binding site [chemical binding]; other site
688269000825	metal binding site [ion binding]; metal-binding site
688269000826	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
688269000827	generic binding surface I; other site
688269000828	generic binding surface II; other site
688269000829	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688269000830	Zn2+ binding site [ion binding]; other site
688269000831	Mg2+ binding site [ion binding]; other site
688269000832	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688269000833	putative substrate translocation pore; other site
688269000834	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
688269000835	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
688269000836	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269000837	dimer interface [polypeptide binding]; other site
688269000838	conserved gate region; other site
688269000839	putative PBP binding loops; other site
688269000840	ABC-ATPase subunit interface; other site
688269000841	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
688269000842	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269000843	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269000844	dimer interface [polypeptide binding]; other site
688269000845	putative PBP binding loops; other site
688269000846	ABC-ATPase subunit interface; other site
688269000847	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269000848	Rrf2 family protein; Region: rrf2_super; TIGR00738
688269000849	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
688269000850	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
688269000851	homodimer interface [polypeptide binding]; other site
688269000852	substrate-cofactor binding pocket; other site
688269000853	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269000854	catalytic residue [active]
688269000855	Rrf2 family protein; Region: rrf2_super; TIGR00738
688269000856	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269000857	cysteine synthases; Region: cysKM; TIGR01136
688269000858	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561
688269000859	dimer interface [polypeptide binding]; other site
688269000860	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269000861	catalytic residue [active]
688269000862	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
688269000863	proposed active site lysine [active]
688269000864	conserved cys residue [active]
688269000865	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
688269000866	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
688269000867	dihydropteroate synthase; Region: DHPS; TIGR01496
688269000868	substrate binding pocket [chemical binding]; other site
688269000869	dimer interface [polypeptide binding]; other site
688269000870	inhibitor binding site; inhibition site
688269000871	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
688269000872	putative active site [active]
688269000873	putative CoA binding site [chemical binding]; other site
688269000874	nudix motif; other site
688269000875	metal binding site [ion binding]; metal-binding site
688269000876	prolyl-tRNA synthetase; Provisional; Region: PRK09194
688269000877	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779
688269000878	dimer interface [polypeptide binding]; other site
688269000879	motif 1; other site
688269000880	active site
688269000881	motif 2; other site
688269000882	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334
688269000883	putative deacylase active site [active]
688269000884	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
688269000885	active site
688269000886	motif 3; other site
688269000887	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861
688269000888	anticodon binding site; other site
688269000889	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
688269000890	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
688269000891	P loop; other site
688269000892	GTP binding site [chemical binding]; other site
688269000893	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
688269000894	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
688269000895	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
688269000896	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cl00148
688269000897	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
688269000898	putative peptidoglycan binding site; other site
688269000899	Peptidase family M23; Region: Peptidase_M23; pfam01551
688269000900	3D domain; Region: 3D; cl01439
688269000901	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269000902	Rrf2 family protein; Region: rrf2_super; TIGR00738
688269000903	GAF domain; Region: GAF; cl00853
688269000904	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
688269000905	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
688269000906	dimer interface [polypeptide binding]; other site
688269000907	active site
688269000908	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
688269000909	catalytic residues [active]
688269000910	substrate binding site [chemical binding]; other site
688269000911	Uncharacterised protein family UPF0047; Region: UPF0047; cl00439
688269000912	Septum formation topological specificity factor MinE; Region: MinE; cl00538
688269000913	septum site-determining protein MinD; Region: minD_bact; TIGR01968
688269000914	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036
688269000915	Switch I; other site
688269000916	Switch II; other site
688269000917	FOG: CBS domain [General function prediction only]; Region: COG0517
688269000918	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205
688269000919	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
688269000920	Bacitracin resistance protein BacA; Region: BacA; cl00858
688269000921	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688269000922	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
688269000923	DNA polymerase I; Provisional; Region: PRK05755
688269000924	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
688269000925	active site
688269000926	metal binding site 1 [ion binding]; metal-binding site
688269000927	putative 5' ssDNA interaction site; other site
688269000928	metal binding site 3; metal-binding site
688269000929	metal binding site 2 [ion binding]; metal-binding site
688269000930	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
688269000931	putative DNA binding site [nucleotide binding]; other site
688269000932	putative metal binding site [ion binding]; other site
688269000933	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
688269000934	active site
688269000935	catalytic site [active]
688269000936	substrate binding site [chemical binding]; other site
688269000937	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
688269000938	active site
688269000939	DNA binding site [nucleotide binding]
688269000940	catalytic site [active]
688269000941	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
688269000942	CheC-like family; Region: CheC; pfam04509
688269000943	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
688269000944	ATP synthase A chain; Region: ATP-synt_A; cl00413
688269000945	ATP synthase subunit C; Region: ATP-synt_C; cl00466
688269000946	ATP synthase subunit C; Region: ATP-synt_C; cl00466
688269000947	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
688269000948	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
688269000949	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
688269000950	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
688269000951	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
688269000952	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
688269000953	beta subunit interaction interface [polypeptide binding]; other site
688269000954	Walker A motif; other site
688269000955	ATP binding site [chemical binding]; other site
688269000956	Walker B motif; other site
688269000957	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
688269000958	ATP synthase; Region: ATP-synt; cl00365
688269000959	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
688269000960	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
688269000961	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
688269000962	alpha subunit interaction interface [polypeptide binding]; other site
688269000963	Walker A motif; other site
688269000964	ATP binding site [chemical binding]; other site
688269000965	Walker B motif; other site
688269000966	inhibitor binding site; inhibition site
688269000967	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
688269000968	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13444
688269000969	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
688269000970	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552
688269000971	30S subunit binding site; other site
688269000972	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
688269000973	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
688269000974	homodimer interface [polypeptide binding]; other site
688269000975	oligonucleotide binding site [chemical binding]; other site
688269000976	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
688269000977	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
688269000978	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
688269000979	FlaG protein; Region: FlaG; cl00591
688269000980	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
688269000981	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
688269000982	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
688269000983	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
688269000984	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
688269000985	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
688269000986	putative CheA interaction surface; other site
688269000987	oxaloacetate decarboxylase; Provisional; Region: PRK14040
688269000988	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
688269000989	carboxyltransferase (CT) interaction site; other site
688269000990	biotinylation site [posttranslational modification]; other site
688269000991	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
688269000992	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
688269000993	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
688269000994	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
688269000995	dimer interface [polypeptide binding]; other site
688269000996	substrate binding site [chemical binding]; other site
688269000997	metal binding site [ion binding]; metal-binding site
688269000998	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
688269000999	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185
688269001000	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
688269001001	putative active site [active]
688269001002	metal binding site [ion binding]; metal-binding site
688269001003	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
688269001004	putative hydrophobic ligand binding site [chemical binding]; other site
688269001005	Bacterial pullanase-associated domain; Region: PUD; pfam03714
688269001006	pullulanase, type I; Region: pulA_typeI; TIGR02104
688269001007	Pullulanase domain N-terminus. Pullulanase (AKA dextrinase; alpha-dextrin endo-1,6-alpha glucosidase) is an enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-...; Region: Pullulanase_N_term; cd02860
688269001008	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
688269001009	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
688269001010	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688269001011	Sodium:solute symporter family; Region: SSF; cl00456
688269001012	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
688269001013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688269001014	Domain of unknown function DUF59; Region: DUF59; cl00941
688269001015	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
688269001016	diiron binding motif [ion binding]; other site
688269001017	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
688269001018	Ferritin-like domain; Region: Ferritin; pfam00210
688269001019	ferroxidase diiron center [ion binding]; other site
688269001020	peroxiredoxin; Provisional; Region: PRK13189
688269001021	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
688269001022	dimer interface [polypeptide binding]; other site
688269001023	decamer (pentamer of dimers) interface [polypeptide binding]; other site
688269001024	catalytic triad [active]
688269001025	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
688269001026	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269001027	dimer interface [polypeptide binding]; other site
688269001028	conserved gate region; other site
688269001029	putative PBP binding loops; other site
688269001030	ABC-ATPase subunit interface; other site
688269001031	Uncharacterized conserved protein [Function unknown]; Region: COG1912
688269001032	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
688269001033	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
688269001034	DHH family; Region: DHH; pfam01368
688269001035	FOG: CBS domain [General function prediction only]; Region: COG0517
688269001036	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
688269001037	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
688269001038	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
688269001039	active site
688269001040	NTP binding site [chemical binding]; other site
688269001041	metal binding triad [ion binding]; metal-binding site
688269001042	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
688269001043	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
688269001044	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
688269001045	dimer interface [polypeptide binding]; other site
688269001046	anticodon binding site; other site
688269001047	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
688269001048	homodimer interface [polypeptide binding]; other site
688269001049	motif 1; other site
688269001050	active site
688269001051	motif 2; other site
688269001052	GAD domain; Region: GAD; pfam02938
688269001053	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
688269001054	motif 3; other site
688269001055	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
688269001056	anti sigma factor interaction site; other site
688269001057	regulatory phosphorylation site [posttranslational modification]; other site
688269001058	cytidylate kinase; Provisional; Region: cmk; PRK00023
688269001059	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
688269001060	CMP-binding site; other site
688269001061	The sites determining sugar specificity; other site
688269001062	LytB protein; Region: LYTB; cl00507
688269001063	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
688269001064	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
688269001065	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
688269001066	RNA binding site [nucleotide binding]; other site
688269001067	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
688269001068	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
688269001069	RNA binding site [nucleotide binding]; other site
688269001070	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
688269001071	RNA binding site [nucleotide binding]; other site
688269001072	GTP-binding protein Der; Reviewed; Region: PRK00093
688269001073	EngA1 subfamily.  This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894
688269001074	G1 box; other site
688269001075	GTP/Mg2+ binding site [chemical binding]; other site
688269001076	Switch I region; other site
688269001077	G2 box; other site
688269001078	Switch II region; other site
688269001079	G3 box; other site
688269001080	G4 box; other site
688269001081	G5 box; other site
688269001082	EngA2 subfamily.  This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895
688269001083	G1 box; other site
688269001084	GTP/Mg2+ binding site [chemical binding]; other site
688269001085	Switch I region; other site
688269001086	G2 box; other site
688269001087	G3 box; other site
688269001088	Switch II region; other site
688269001089	G4 box; other site
688269001090	G5 box; other site
688269001091	Domain of unknown function (DUF205); Region: DUF205; cl00410
688269001092	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
688269001093	binding surface
688269001094	TPR motif; other site
688269001095	RNA polymerase factor sigma-70; Validated; Region: PRK08295
688269001096	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688269001097	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
688269001098	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688269001099	active site
688269001100	motif I; other site
688269001101	motif II; other site
688269001102	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688269001103	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
688269001104	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
688269001105	domain; Region: Glyco_hydro_2; pfam00703
688269001106	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family...; Region: NanE; cd04729
688269001107	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
688269001108	putative active site cavity [active]
688269001109	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688269001110	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269001111	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269001112	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
688269001113	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269001114	dimer interface [polypeptide binding]; other site
688269001115	conserved gate region; other site
688269001116	putative PBP binding loops; other site
688269001117	ABC-ATPase subunit interface; other site
688269001118	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
688269001119	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
688269001120	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
688269001121	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
688269001122	putative active site [active]
688269001123	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
688269001124	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688269001125	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
688269001126	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
688269001127	active site
688269001128	dimer interface [polypeptide binding]; other site
688269001129	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
688269001130	dimer interface [polypeptide binding]; other site
688269001131	active site
688269001132	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
688269001133	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
688269001134	CoA-binding site [chemical binding]; other site
688269001135	ATP-binding [chemical binding]; other site
688269001136	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269001137	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688269001138	pantoate--beta-alanine ligase; Region: panC; TIGR00018
688269001139	Pantoate-beta-alanine ligase; Region: PanC; cd00560
688269001140	active site
688269001141	ATP-binding site [chemical binding]; other site
688269001142	pantoate-binding site; other site
688269001143	HXXH motif; other site
688269001144	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
688269001145	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688269001146	DNA-binding site [nucleotide binding]; DNA binding site
688269001147	UTRA domain; Region: UTRA; cl01230
688269001148	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
688269001149	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
688269001150	putative active site [active]
688269001151	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
688269001152	Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086
688269001153	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
688269001154	Ligand binding site [chemical binding]; other site
688269001155	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
688269001156	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
688269001157	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
688269001158	FAD binding domain; Region: FAD_binding_4; pfam01565
688269001159	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
688269001160	Cache domain; Region: Cache_1; pfam02743
688269001161	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
688269001162	dimerization interface [polypeptide binding]; other site
688269001163	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688269001164	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
688269001165	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
688269001166	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
688269001167	active site
688269001168	NTP binding site [chemical binding]; other site
688269001169	metal binding triad [ion binding]; metal-binding site
688269001170	antibiotic binding site [chemical binding]; other site
688269001171	HEPN domain; Region: HEPN; cl00824
688269001172	ABC-2 type transporter; Region: ABC2_membrane; cl11417
688269001173	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
688269001174	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
688269001175	Walker A/P-loop; other site
688269001176	ATP binding site [chemical binding]; other site
688269001177	Q-loop/lid; other site
688269001178	ABC transporter signature motif; other site
688269001179	Walker B; other site
688269001180	D-loop; other site
688269001181	H-loop/switch region; other site
688269001182	Domain of unknown function (DUF370); Region: DUF370; cl00898
688269001183	UGMP family protein; Validated; Region: PRK09604
688269001184	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
688269001185	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
688269001186	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
688269001187	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269001188	Walker A motif; other site
688269001189	ATP binding site [chemical binding]; other site
688269001190	Walker B motif; other site
688269001191	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
688269001192	B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013
688269001193	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
688269001194	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269001195	FeS/SAM binding site; other site
688269001196	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
688269001197	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
688269001198	NAD synthetase; Provisional; Region: PRK13981
688269001199	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
688269001200	active site
688269001201	catalytic triad [active]
688269001202	dimer interface [polypeptide binding]; other site
688269001203	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553
688269001204	homodimer interface [polypeptide binding]; other site
688269001205	NAD binding pocket [chemical binding]; other site
688269001206	ATP binding pocket [chemical binding]; other site
688269001207	Mg binding site [ion binding]; other site
688269001208	active-site loop [active]
688269001209	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
688269001210	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
688269001211	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
688269001212	CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083
688269001213	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
688269001214	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14319
688269001215	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802
688269001216	active site
688269001217	substrate binding site [chemical binding]; other site
688269001218	metal binding site [ion binding]; metal-binding site
688269001219	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
688269001220	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
688269001221	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
688269001222	FAD binding domain; Region: FAD_binding_4; pfam01565
688269001223	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
688269001224	Glycerophosphodiester phosphodiesterase domain of Thermotoga maritime and similar proteins; Region: GDPD_TmGDE_like; cd08568
688269001225	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
688269001226	putative active site [active]
688269001227	catalytic site [active]
688269001228	putative metal binding site [ion binding]; other site
688269001229	Protein of unknown function (DUF3242); Region: DUF3242; pfam11586
688269001230	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688269001231	nuclease NucT; Provisional; Region: PRK13912
688269001232	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
688269001233	putative active site [active]
688269001234	catalytic site [active]
688269001235	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
688269001236	putative active site [active]
688269001237	catalytic site [active]
688269001238	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688269001239	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
688269001240	active site
688269001241	motif I; other site
688269001242	motif II; other site
688269001243	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688269001244	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554
688269001245	homotrimer interaction site [polypeptide binding]; other site
688269001246	zinc binding site [ion binding]; other site
688269001247	CDP-binding sites; other site
688269001248	replicative DNA helicase; Region: DnaB; TIGR00665
688269001249	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
688269001250	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
688269001251	Walker A motif; other site
688269001252	ATP binding site [chemical binding]; other site
688269001253	Walker B motif; other site
688269001254	DNA binding loops [nucleotide binding]
688269001255	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688269001256	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688269001257	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269001258	FeS/SAM binding site; other site
688269001259	TM0106 family; Region: TIGR03491
688269001260	tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832
688269001261	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
688269001262	active sites [active]
688269001263	tetramer interface [polypeptide binding]; other site
688269001264	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
688269001265	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
688269001266	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269001267	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
688269001268	Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933
688269001269	phosphate binding site [ion binding]; other site
688269001270	putative substrate binding pocket [chemical binding]; other site
688269001271	dimer interface [polypeptide binding]; other site
688269001272	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
688269001273	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
688269001274	ATP cone domain; Region: ATP-cone; pfam03477
688269001275	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
688269001276	domain; Region: GreA_GreB_N; pfam03449
688269001277	C-term; Region: GreA_GreB; pfam01272
688269001278	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
688269001279	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322
688269001280	dimer interface [polypeptide binding]; other site
688269001281	putative anticodon binding site; other site
688269001282	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
688269001283	motif 1; other site
688269001284	active site
688269001285	motif 2; other site
688269001286	motif 3; other site
688269001287	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
688269001288	homoserine kinase; Provisional; Region: PRK01212
688269001289	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
688269001290	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
688269001291	threonine synthase; Reviewed; Region: PRK06721
688269001292	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563
688269001293	homodimer interface [polypeptide binding]; other site
688269001294	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269001295	catalytic residue [active]
688269001296	homoserine dehydrogenase; Provisional; Region: PRK06349
688269001297	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269001298	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
688269001299	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
688269001300	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688269001301	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269001302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269001303	dimer interface [polypeptide binding]; other site
688269001304	conserved gate region; other site
688269001305	putative PBP binding loops; other site
688269001306	ABC-ATPase subunit interface; other site
688269001307	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
688269001308	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269001309	dimer interface [polypeptide binding]; other site
688269001310	conserved gate region; other site
688269001311	putative PBP binding loops; other site
688269001312	ABC-ATPase subunit interface; other site
688269001313	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
688269001314	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
688269001315	KduI/IolB family; Region: KduI; cl01508
688269001316	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
688269001317	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032
688269001318	hypothetical protein; Reviewed; Region: PRK09588
688269001319	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688269001320	putative substrate translocation pore; other site
688269001321	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178
688269001322	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
688269001323	diiron binding motif [ion binding]; other site
688269001324	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
688269001325	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
688269001326	dimer interface [polypeptide binding]; other site
688269001327	PYR/PP interface [polypeptide binding]; other site
688269001328	TPP binding site [chemical binding]; other site
688269001329	substrate binding site [chemical binding]; other site
688269001330	Ferredoxin [Energy production and conversion]; Region: COG1146
688269001331	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
688269001332	subunit; Region: OAD_beta; cl00816
688269001333	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
688269001334	Fumarase C-terminus; Region: Fumerase_C; cl00795
688269001335	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
688269001336	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
688269001337	Cation transport protein; Region: TrkH; cl10514
688269001338	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
688269001339	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269001340	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688269001341	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269001342	Response regulator receiver domain; Region: Response_reg; pfam00072
688269001343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688269001344	active site
688269001345	phosphorylation site [posttranslational modification]
688269001346	intermolecular recognition site; other site
688269001347	dimerization interface [polypeptide binding]; other site
688269001348	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269001349	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
688269001350	Protein export membrane protein; Region: SecD_SecF; cl14618
688269001351	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
688269001352	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
688269001353	putative NADP binding site [chemical binding]; other site
688269001354	putative substrate binding site [chemical binding]; other site
688269001355	active site
688269001356	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
688269001357	active site
688269001358	dimer interfaces [polypeptide binding]; other site
688269001359	catalytic residues [active]
688269001360	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688269001361	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
688269001362	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688269001363	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
688269001364	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269001365	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269001366	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
688269001367	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688269001368	catalytic loop [active]
688269001369	iron binding site [ion binding]; other site
688269001370	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
688269001371	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
688269001372	4Fe-4S binding domain; Region: Fer4; cl02805
688269001373	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
688269001374	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
688269001375	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
688269001376	Preprotein translocase subunit; Region: YajC; cl00806
688269001377	protein-export membrane protein SecD; Region: secD; TIGR01129
688269001378	Protein export membrane protein; Region: SecD_SecF; cl14618
688269001379	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
688269001380	Protein export membrane protein; Region: SecD_SecF; cl14618
688269001381	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
688269001382	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
688269001383	substrate binding site [chemical binding]; other site
688269001384	metal binding site [ion binding]; metal-binding site
688269001385	Oligomer interface [polypeptide binding]; other site
688269001386	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
688269001387	Flavin Reductases; Region: FlaRed; cl00801
688269001388	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
688269001389	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
688269001390	NADP binding site [chemical binding]; other site
688269001391	homodimer interface [polypeptide binding]; other site
688269001392	active site
688269001393	4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947
688269001394	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
688269001395	Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112
688269001396	Thymidine kinase; Region: TK; cl00631
688269001397	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
688269001398	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
688269001399	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
688269001400	DNA binding site [nucleotide binding]
688269001401	Int/Topo IB signature motif; other site
688269001402	active site
688269001403	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
688269001404	transmembrane helices; other site
688269001405	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
688269001406	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
688269001407	dimer interface [polypeptide binding]; other site
688269001408	putative functional site; other site
688269001409	putative MPT binding site; other site
688269001410	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886
688269001411	MPT binding site; other site
688269001412	trimer interface [polypeptide binding]; other site
688269001413	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
688269001414	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
688269001415	dimer interface [polypeptide binding]; other site
688269001416	putative functional site; other site
688269001417	putative MPT binding site; other site
688269001418	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269001419	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
688269001420	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
688269001421	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688269001422	S-adenosylmethionine binding site [chemical binding]; other site
688269001423	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
688269001424	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
688269001425	NAD binding site [chemical binding]; other site
688269001426	sugar binding site [chemical binding]; other site
688269001427	divalent metal binding site [ion binding]; other site
688269001428	tetramer (dimer of dimers) interface [polypeptide binding]; other site
688269001429	dimer interface [polypeptide binding]; other site
688269001430	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
688269001431	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
688269001432	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
688269001433	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
688269001434	Sulfatase; Region: Sulfatase; cl10460
688269001435	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
688269001436	Adenosine specific kinase; Region: Adenosine_kin; cl00796
688269001437	AIR carboxylase; Region: AIRC; cl00310
688269001438	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
688269001439	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
688269001440	ATP binding site [chemical binding]; other site
688269001441	active site
688269001442	substrate binding site [chemical binding]; other site
688269001443	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
688269001444	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
688269001445	putative active site [active]
688269001446	catalytic triad [active]
688269001447	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
688269001448	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203
688269001449	dimerization interface [polypeptide binding]; other site
688269001450	ATP binding site [chemical binding]; other site
688269001451	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204
688269001452	dimerization interface [polypeptide binding]; other site
688269001453	ATP binding site [chemical binding]; other site
688269001454	amidophosphoribosyltransferase; Provisional; Region: PRK05793
688269001455	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
688269001456	active site
688269001457	tetramer interface [polypeptide binding]; other site
688269001458	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688269001459	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
688269001460	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196
688269001461	dimerization interface [polypeptide binding]; other site
688269001462	putative ATP binding site [chemical binding]; other site
688269001463	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
688269001464	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
688269001465	active site
688269001466	substrate binding site [chemical binding]; other site
688269001467	cosubstrate binding site; other site
688269001468	catalytic site [active]
688269001469	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
688269001470	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421
688269001471	purine monophosphate binding site [chemical binding]; other site
688269001472	dimer interface [polypeptide binding]; other site
688269001473	putative catalytic residues [active]
688269001474	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
688269001475	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
688269001476	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
688269001477	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
688269001478	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688269001479	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
688269001480	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269001481	FeS/SAM binding site; other site
688269001482	Uncharacterized conserved protein [Function unknown]; Region: COG5276
688269001483	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
688269001484	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174
688269001485	substrate binding site [chemical binding]; other site
688269001486	dimer interface [polypeptide binding]; other site
688269001487	ATP binding site [chemical binding]; other site
688269001488	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
688269001489	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
688269001490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269001491	dimer interface [polypeptide binding]; other site
688269001492	conserved gate region; other site
688269001493	putative PBP binding loops; other site
688269001494	ABC-ATPase subunit interface; other site
688269001495	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
688269001496	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269001497	dimer interface [polypeptide binding]; other site
688269001498	conserved gate region; other site
688269001499	putative PBP binding loops; other site
688269001500	ABC-ATPase subunit interface; other site
688269001501	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
688269001502	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
688269001503	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
688269001504	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
688269001505	MatE; Region: MatE; cl10513
688269001506	MatE; Region: MatE; cl10513
688269001507	L-aspartate dehydrogenase; Provisional; Region: PRK13303
688269001508	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269001509	Domain of unknown function DUF108; Region: DUF108; pfam01958
688269001510	Quinolinate synthetase A protein; Region: NadA; cl00420
688269001511	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572
688269001512	nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078
688269001513	dimerization interface [polypeptide binding]; other site
688269001514	active site
688269001515	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688269001516	Major Facilitator Superfamily; Region: MFS_1; pfam07690
688269001517	putative substrate translocation pore; other site
688269001518	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
688269001519	chorismate binding enzyme; Region: Chorismate_bind; cl10555
688269001520	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
688269001521	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
688269001522	glutamine binding [chemical binding]; other site
688269001523	catalytic triad [active]
688269001524	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
688269001525	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
688269001526	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
688269001527	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
688269001528	active site
688269001529	ribulose/triose binding site [chemical binding]; other site
688269001530	phosphate binding site [ion binding]; other site
688269001531	substrate (anthranilate) binding pocket [chemical binding]; other site
688269001532	product (indole) binding pocket [chemical binding]; other site
688269001533	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405
688269001534	active site
688269001535	tryptophan synthase, beta chain; Region: PLN02618
688269001536	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
688269001537	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269001538	catalytic residue [active]
688269001539	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
688269001540	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724
688269001541	substrate binding site [chemical binding]; other site
688269001542	active site
688269001543	catalytic residues [active]
688269001544	heterodimer interface [polypeptide binding]; other site
688269001545	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
688269001546	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269001547	Chorismate mutase type II; Region: CM_2; cl00693
688269001548	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
688269001549	Prephenate dehydratase; Region: PDT; pfam00800
688269001550	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
688269001551	putative L-Phe binding site [chemical binding]; other site
688269001552	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
688269001553	trimer interface [polypeptide binding]; other site
688269001554	active site
688269001555	dimer interface [polypeptide binding]; other site
688269001556	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464
688269001557	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
688269001558	ADP binding site [chemical binding]; other site
688269001559	magnesium binding site [ion binding]; other site
688269001560	putative shikimate binding site; other site
688269001561	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
688269001562	active site
688269001563	dimer interface [polypeptide binding]; other site
688269001564	metal binding site [ion binding]; metal-binding site
688269001565	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
688269001566	Tetramer interface [polypeptide binding]; other site
688269001567	Active site [active]
688269001568	FMN-binding site [chemical binding]; other site
688269001569	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
688269001570	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
688269001571	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
688269001572	shikimate binding site; other site
688269001573	NAD(P) binding site [chemical binding]; other site
688269001574	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
688269001575	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556
688269001576	hinge; other site
688269001577	active site
688269001578	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
688269001579	NeuB family; Region: NeuB; cl00496
688269001580	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688269001581	transmembrane helices; other site
688269001582	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
688269001583	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269001584	Walker A/P-loop; other site
688269001585	ATP binding site [chemical binding]; other site
688269001586	Q-loop/lid; other site
688269001587	ABC transporter signature motif; other site
688269001588	Walker B; other site
688269001589	D-loop; other site
688269001590	H-loop/switch region; other site
688269001591	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
688269001592	isocitrate dehydrogenase; Validated; Region: PRK06451
688269001593	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577
688269001594	substrate binding site [chemical binding]; other site
688269001595	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
688269001596	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
688269001597	substrate binding site [chemical binding]; other site
688269001598	ligand binding site [chemical binding]; other site
688269001599	2-isopropylmalate synthase; Validated; Region: PRK00915
688269001600	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
688269001601	active site
688269001602	catalytic residues [active]
688269001603	metal binding site [ion binding]; metal-binding site
688269001604	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
688269001605	Cache domain; Region: Cache_2; cl07034
688269001606	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
688269001607	dimerization interface [polypeptide binding]; other site
688269001608	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
688269001609	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688269001610	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
688269001611	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342
688269001612	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
688269001613	catalytic residue [active]
688269001614	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
688269001615	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
688269001616	Bacterial type II and III secretion system protein; Region: Secretin; cl02829
688269001617	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
688269001618	Peptidase family M48; Region: Peptidase_M48; cl12018
688269001619	Uncharacterised protein family UPF0047; Region: UPF0047; cl00439
688269001620	Membrane transport protein; Region: Mem_trans; cl09117
688269001621	Uncharacterized conserved protein [Function unknown]; Region: COG2006
688269001622	Domain of unknown function (DUF362); Region: DUF362; pfam04015
688269001623	4Fe-4S binding domain; Region: Fer4; cl02805
688269001624	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269001625	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
688269001626	oligomerization interface [polypeptide binding]; other site
688269001627	active site
688269001628	NAD+ binding site [chemical binding]; other site
688269001629	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
688269001630	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
688269001631	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269001632	Walker A/P-loop; other site
688269001633	ATP binding site [chemical binding]; other site
688269001634	Q-loop/lid; other site
688269001635	Uncharacterized conserved protein [Function unknown]; Region: COG4717
688269001636	GAF domain; Region: GAF; cl00853
688269001637	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688269001638	metal binding site [ion binding]; metal-binding site
688269001639	active site
688269001640	I-site; other site
688269001641	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
688269001642	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269001643	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
688269001644	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
688269001645	active site
688269001646	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
688269001647	homodimer interface [polypeptide binding]; other site
688269001648	Fumarase C-terminus; Region: Fumerase_C; cl00795
688269001649	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
688269001650	active site
688269001651	putative substrate binding region [chemical binding]; other site
688269001652	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
688269001653	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
688269001654	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269001655	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
688269001656	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537
688269001657	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
688269001658	FAD binding site [chemical binding]; other site
688269001659	ApbE family; Region: ApbE; cl00643
688269001660	Domain of unknown function DUF39; Region: DUF39; cl14897
688269001661	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
688269001662	Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527
688269001663	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
688269001664	nucleotide binding site [chemical binding]; other site
688269001665	substrate binding site [chemical binding]; other site
688269001666	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
688269001667	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
688269001668	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
688269001669	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105
688269001670	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
688269001671	Pterin binding enzyme; Region: Pterin_bind; pfam00809
688269001672	substrate binding pocket [chemical binding]; other site
688269001673	dimer interface [polypeptide binding]; other site
688269001674	inhibitor binding site; inhibition site
688269001675	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
688269001676	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293
688269001677	B12 binding site [chemical binding]; other site
688269001678	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
688269001679	Esterase/lipase [General function prediction only]; Region: COG1647
688269001680	Arginase family; Region: Arginase; cl00306
688269001681	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
688269001682	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269001683	FeS/SAM binding site; other site
688269001684	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
688269001685	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420
688269001686	trimer interface [polypeptide binding]; other site
688269001687	dimer interface [polypeptide binding]; other site
688269001688	putative active site [active]
688269001689	MOSC domain; Region: MOSC; pfam03473
688269001690	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269001691	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269001692	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
688269001693	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
688269001694	Walker A/P-loop; other site
688269001695	ATP binding site [chemical binding]; other site
688269001696	Q-loop/lid; other site
688269001697	ABC transporter signature motif; other site
688269001698	Walker B; other site
688269001699	D-loop; other site
688269001700	H-loop/switch region; other site
688269001701	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688269001702	dimer interface [polypeptide binding]; other site
688269001703	phosphorylation site [posttranslational modification]
688269001704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688269001705	ATP binding site [chemical binding]; other site
688269001706	Mg2+ binding site [ion binding]; other site
688269001707	G-X-G motif; other site
688269001708	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688269001709	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
688269001710	active site
688269001711	phosphorylation site [posttranslational modification]
688269001712	intermolecular recognition site; other site
688269001713	dimerization interface [polypeptide binding]; other site
688269001714	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688269001715	DNA binding site [nucleotide binding]
688269001716	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269001717	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
688269001718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269001719	dimer interface [polypeptide binding]; other site
688269001720	conserved gate region; other site
688269001721	putative PBP binding loops; other site
688269001722	ABC-ATPase subunit interface; other site
688269001723	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
688269001724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269001725	dimer interface [polypeptide binding]; other site
688269001726	conserved gate region; other site
688269001727	ABC-ATPase subunit interface; other site
688269001728	phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972
688269001729	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
688269001730	Walker A/P-loop; other site
688269001731	ATP binding site [chemical binding]; other site
688269001732	Q-loop/lid; other site
688269001733	ABC transporter signature motif; other site
688269001734	Walker B; other site
688269001735	D-loop; other site
688269001736	H-loop/switch region; other site
688269001737	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
688269001738	PhoU domain; Region: PhoU; pfam01895
688269001739	PhoU domain; Region: PhoU; pfam01895
688269001740	glyoxylate reductase; Reviewed; Region: PRK13243
688269001741	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269001742	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
688269001743	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269001744	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
688269001745	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
688269001746	Dimer interface [polypeptide binding]; other site
688269001747	anticodon binding site; other site
688269001748	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776
688269001749	homodimer interface [polypeptide binding]; other site
688269001750	motif 1; other site
688269001751	motif 2; other site
688269001752	active site
688269001753	motif 3; other site
688269001754	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
688269001755	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269001756	Walker A motif; other site
688269001757	ATP binding site [chemical binding]; other site
688269001758	Walker B motif; other site
688269001759	arginine finger; other site
688269001760	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
688269001761	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
688269001762	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
688269001763	catalytic residue [active]
688269001764	YGGT family; Region: YGGT; cl00508
688269001765	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
688269001766	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
688269001767	PhoU domain; Region: PhoU; pfam01895
688269001768	PhoU domain; Region: PhoU; pfam01895
688269001769	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
688269001770	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
688269001771	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
688269001772	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
688269001773	UvrD/REP helicase; Region: UvrD-helicase; cl14126
688269001774	UvrD/REP helicase; Region: UvrD-helicase; cl14126
688269001775	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
688269001776	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269001777	Walker A/P-loop; other site
688269001778	ATP binding site [chemical binding]; other site
688269001779	Q-loop/lid; other site
688269001780	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
688269001781	Q-loop/lid; other site
688269001782	ABC transporter signature motif; other site
688269001783	Walker B; other site
688269001784	D-loop; other site
688269001785	H-loop/switch region; other site
688269001786	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
688269001787	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
688269001788	active site
688269001789	putative substrate binding pocket [chemical binding]; other site
688269001790	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688269001791	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688269001792	Zn2+ binding site [ion binding]; other site
688269001793	Mg2+ binding site [ion binding]; other site
688269001794	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
688269001795	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
688269001796	Heme NO binding; Region: HNOB; cl15268
688269001797	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
688269001798	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
688269001799	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269001800	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
688269001801	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688269001802	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
688269001803	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
688269001804	inhibitor-cofactor binding pocket; inhibition site
688269001805	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269001806	catalytic residue [active]
688269001807	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005
688269001808	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
688269001809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688269001810	active site
688269001811	phosphorylation site [posttranslational modification]
688269001812	intermolecular recognition site; other site
688269001813	dimerization interface [polypeptide binding]; other site
688269001814	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688269001815	DNA binding site [nucleotide binding]
688269001816	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688269001817	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
688269001818	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688269001819	dimer interface [polypeptide binding]; other site
688269001820	phosphorylation site [posttranslational modification]
688269001821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688269001822	ATP binding site [chemical binding]; other site
688269001823	Mg2+ binding site [ion binding]; other site
688269001824	G-X-G motif; other site
688269001825	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
688269001826	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
688269001827	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
688269001828	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
688269001829	Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632
688269001830	Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481
688269001831	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170
688269001832	elongation factor G; Reviewed; Region: PRK12740
688269001833	G1 box; other site
688269001834	putative GEF interaction site [polypeptide binding]; other site
688269001835	GTP/Mg2+ binding site [chemical binding]; other site
688269001836	Switch I region; other site
688269001837	G2 box; other site
688269001838	G3 box; other site
688269001839	Switch II region; other site
688269001840	G4 box; other site
688269001841	G5 box; other site
688269001842	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088
688269001843	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434
688269001844	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713
688269001845	Protein of unknown function (DUF503); Region: DUF503; cl00669
688269001846	Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713
688269001847	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688269001848	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976
688269001849	catalytic residues [active]
688269001850	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
688269001851	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
688269001852	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
688269001853	dimer interface [polypeptide binding]; other site
688269001854	substrate binding site [chemical binding]; other site
688269001855	catalytic triad [active]
688269001856	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
688269001857	substrate binding site [chemical binding]; other site
688269001858	hinge regions; other site
688269001859	ADP binding site [chemical binding]; other site
688269001860	catalytic site [active]
688269001861	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267
688269001862	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
688269001863	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
688269001864	Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494
688269001865	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14962
688269001866	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269001867	Walker A motif; other site
688269001868	ATP binding site [chemical binding]; other site
688269001869	Walker B motif; other site
688269001870	arginine finger; other site
688269001871	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
688269001872	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
688269001873	N-acetyl-D-glucosamine binding site [chemical binding]; other site
688269001874	catalytic residue [active]
688269001875	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
688269001876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688269001877	active site
688269001878	phosphorylation site [posttranslational modification]
688269001879	intermolecular recognition site; other site
688269001880	dimerization interface [polypeptide binding]; other site
688269001881	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688269001882	DNA binding site [nucleotide binding]
688269001883	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
688269001884	dimerization interface [polypeptide binding]; other site
688269001885	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688269001886	dimer interface [polypeptide binding]; other site
688269001887	phosphorylation site [posttranslational modification]
688269001888	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688269001889	ATP binding site [chemical binding]; other site
688269001890	Mg2+ binding site [ion binding]; other site
688269001891	G-X-G motif; other site
688269001892	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
688269001893	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
688269001894	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688269001895	Zn2+ binding site [ion binding]; other site
688269001896	Mg2+ binding site [ion binding]; other site
688269001897	The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263
688269001898	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
688269001899	Walker A/P-loop; other site
688269001900	ATP binding site [chemical binding]; other site
688269001901	Q-loop/lid; other site
688269001902	ABC transporter signature motif; other site
688269001903	Walker B; other site
688269001904	D-loop; other site
688269001905	H-loop/switch region; other site
688269001906	ABC-2 type transporter; Region: ABC2_membrane; cl11417
688269001907	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
688269001908	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
688269001909	Response regulator receiver domain; Region: Response_reg; pfam00072
688269001910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688269001911	active site
688269001912	phosphorylation site [posttranslational modification]
688269001913	intermolecular recognition site; other site
688269001914	dimerization interface [polypeptide binding]; other site
688269001915	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
688269001916	GAF domain; Region: GAF; cl00853
688269001917	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
688269001918	Domain of unknown function DUF28; Region: DUF28; cl00361
688269001919	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
688269001920	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
688269001921	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688269001922	S-adenosylmethionine binding site [chemical binding]; other site
688269001923	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
688269001924	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
688269001925	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
688269001926	RNA binding surface [nucleotide binding]; other site
688269001927	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
688269001928	active site
688269001929	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
688269001930	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
688269001931	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
688269001932	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
688269001933	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
688269001934	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
688269001935	active site
688269001936	HerA helicase [Replication, recombination, and repair]; Region: COG0433
688269001937	HerA helicase [Replication, recombination, and repair]; Region: COG0433
688269001938	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
688269001939	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378
688269001940	dimer interface [polypeptide binding]; other site
688269001941	glycine-pyridoxal phosphate binding site [chemical binding]; other site
688269001942	active site
688269001943	folate binding site [chemical binding]; other site
688269001944	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
688269001945	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
688269001946	active site
688269001947	HIGH motif; other site
688269001948	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
688269001949	KMSKS motif; other site
688269001950	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
688269001951	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
688269001952	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
688269001953	HIGH motif; other site
688269001954	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
688269001955	active site
688269001956	KMSKS motif; other site
688269001957	N-glycosylase/DNA lyase; Provisional; Region: PRK01229
688269001958	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
688269001959	minor groove reading motif; other site
688269001960	helix-hairpin-helix signature motif; other site
688269001961	substrate binding pocket [chemical binding]; other site
688269001962	active site
688269001963	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
688269001964	metal binding site 2 [ion binding]; metal-binding site
688269001965	putative DNA binding helix; other site
688269001966	metal binding site 1 [ion binding]; metal-binding site
688269001967	dimer interface [polypeptide binding]; other site
688269001968	structural Zn2+ binding site [ion binding]; other site
688269001969	translation initiation factor IF-2; Region: IF-2; TIGR00487
688269001970	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
688269001971	IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily.  IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits.  As seen in other GTPases...; Region: IF2_eIF5B; cd01887
688269001972	G1 box; other site
688269001973	putative GEF interaction site [polypeptide binding]; other site
688269001974	GTP/Mg2+ binding site [chemical binding]; other site
688269001975	Switch I region; other site
688269001976	G2 box; other site
688269001977	G3 box; other site
688269001978	Switch II region; other site
688269001979	G4 box; other site
688269001980	G5 box; other site
688269001981	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702
688269001982	Translation-initiation factor 2; Region: IF-2; pfam11987
688269001983	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692
688269001984	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293
688269001985	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
688269001986	Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130
688269001987	Protein of unknown function (DUF554); Region: DUF554; cl00784
688269001988	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
688269001989	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
688269001990	Mg++ binding site [ion binding]; other site
688269001991	putative catalytic motif [active]
688269001992	substrate binding site [chemical binding]; other site
688269001993	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
688269001994	O-Antigen ligase; Region: Wzy_C; cl04850
688269001995	chromosome segregation protein; Provisional; Region: PRK03918
688269001996	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
688269001997	active site
688269001998	HslU subunit interaction site [polypeptide binding]; other site
688269001999	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
688269002000	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269002001	Walker A motif; other site
688269002002	ATP binding site [chemical binding]; other site
688269002003	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269002004	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
688269002005	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269002006	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269002007	dimer interface [polypeptide binding]; other site
688269002008	conserved gate region; other site
688269002009	putative PBP binding loops; other site
688269002010	ABC-ATPase subunit interface; other site
688269002011	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688269002012	IPP transferase; Region: IPPT; cl00403
688269002013	Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716
688269002014	Sm1 motif; other site
688269002015	intra - hexamer interaction site; other site
688269002016	inter - hexamer interaction site [polypeptide binding]; other site
688269002017	nucleotide binding pocket [chemical binding]; other site
688269002018	Sm2 motif; other site
688269002019	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
688269002020	HflX subfamily.  A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily.  The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878
688269002021	G1 box; other site
688269002022	GTP/Mg2+ binding site [chemical binding]; other site
688269002023	Switch I region; other site
688269002024	G2 box; other site
688269002025	G3 box; other site
688269002026	Switch II region; other site
688269002027	G4 box; other site
688269002028	G5 box; other site
688269002029	Peptidase family M23; Region: Peptidase_M23; pfam01551
688269002030	S-adenosylmethionine synthetase; Validated; Region: PRK05250
688269002031	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
688269002032	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
688269002033	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
688269002034	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
688269002035	CAAX amino terminal protease self- immunity; Region: Abi; cl00558
688269002036	Clp protease ATP binding subunit; Region: clpC; CHL00095
688269002037	Clp amino terminal domain; Region: Clp_N; pfam02861
688269002038	Clp amino terminal domain; Region: Clp_N; pfam02861
688269002039	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269002040	Walker A motif; other site
688269002041	ATP binding site [chemical binding]; other site
688269002042	Walker B motif; other site
688269002043	arginine finger; other site
688269002044	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269002045	Walker A motif; other site
688269002046	ATP binding site [chemical binding]; other site
688269002047	Walker B motif; other site
688269002048	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
688269002049	DNA repair protein RadA; Provisional; Region: PRK11823
688269002050	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269002051	Walker A motif; other site
688269002052	ATP binding site [chemical binding]; other site
688269002053	Walker B motif; other site
688269002054	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
688269002055	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
688269002056	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
688269002057	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
688269002058	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
688269002059	Ribonuclease P; Region: Ribonuclease_P; cl00457
688269002060	Domain of unknown function DUF37; Region: DUF37; cl00506
688269002061	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
688269002062	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
688269002063	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098
688269002064	G-X-X-G motif; other site
688269002065	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
688269002066	RxxxH motif; other site
688269002067	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
688269002068	substrate binding site [chemical binding]; other site
688269002069	dimer interface [polypeptide binding]; other site
688269002070	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688269002071	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
688269002072	putative ligand binding site [chemical binding]; other site
688269002073	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
688269002074	TM-ABC transporter signature motif; other site
688269002075	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
688269002076	TM-ABC transporter signature motif; other site
688269002077	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
688269002078	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
688269002079	Walker A/P-loop; other site
688269002080	ATP binding site [chemical binding]; other site
688269002081	Q-loop/lid; other site
688269002082	ABC transporter signature motif; other site
688269002083	Walker B; other site
688269002084	D-loop; other site
688269002085	H-loop/switch region; other site
688269002086	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
688269002087	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
688269002088	Walker A/P-loop; other site
688269002089	ATP binding site [chemical binding]; other site
688269002090	Q-loop/lid; other site
688269002091	ABC transporter signature motif; other site
688269002092	Walker B; other site
688269002093	D-loop; other site
688269002094	H-loop/switch region; other site
688269002095	Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577
688269002096	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
688269002097	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688269002098	Zn2+ binding site [ion binding]; other site
688269002099	Mg2+ binding site [ion binding]; other site
688269002100	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
688269002101	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
688269002102	FtsX-like permease family; Region: FtsX; pfam02687
688269002103	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
688269002104	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
688269002105	Walker A/P-loop; other site
688269002106	ATP binding site [chemical binding]; other site
688269002107	Q-loop/lid; other site
688269002108	ABC transporter signature motif; other site
688269002109	Walker B; other site
688269002110	D-loop; other site
688269002111	H-loop/switch region; other site
688269002112	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
688269002113	HlyD family secretion protein; Region: HlyD_2; pfam12700
688269002114	Outer membrane efflux protein; Region: OEP; pfam02321
688269002115	Outer membrane efflux protein; Region: OEP; pfam02321
688269002116	Outer membrane efflux protein; Region: OEP; pfam02321
688269002117	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
688269002118	Predicted membrane protein [Function unknown]; Region: COG4907
688269002119	Uncharacterized conserved protein [Function unknown]; Region: COG3595
688269002120	Protein of unknown function(DUF2089); Region: DUF2089; pfam09862
688269002121	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254
688269002122	putative nucleotide binding site [chemical binding]; other site
688269002123	uridine monophosphate binding site [chemical binding]; other site
688269002124	homohexameric interface [polypeptide binding]; other site
688269002125	enolase; Provisional; Region: eno; PRK00077
688269002126	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
688269002127	dimer interface [polypeptide binding]; other site
688269002128	metal binding site [ion binding]; metal-binding site
688269002129	substrate binding pocket [chemical binding]; other site
688269002130	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
688269002131	Cation efflux family; Region: Cation_efflux; cl00316
688269002132	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
688269002133	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
688269002134	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
688269002135	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688269002136	metal binding site [ion binding]; metal-binding site
688269002137	active site
688269002138	I-site; other site
688269002139	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
688269002140	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688269002141	Sulfate transporter family; Region: Sulfate_transp; cl00967
688269002142	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
688269002143	NAD synthetase; Provisional; Region: PRK13981
688269002144	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
688269002145	multimer interface [polypeptide binding]; other site
688269002146	active site
688269002147	catalytic triad [active]
688269002148	protein interface 1 [polypeptide binding]; other site
688269002149	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553
688269002150	homodimer interface [polypeptide binding]; other site
688269002151	NAD binding pocket [chemical binding]; other site
688269002152	ATP binding pocket [chemical binding]; other site
688269002153	Mg binding site [ion binding]; other site
688269002154	active-site loop [active]
688269002155	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269002156	FeS/SAM binding site; other site
688269002157	Major Facilitator Superfamily; Region: MFS_1; pfam07690
688269002158	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
688269002159	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
688269002160	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
688269002161	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
688269002162	ATP binding site [chemical binding]; other site
688269002163	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
688269002164	pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585
688269002165	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688269002166	Coenzyme A binding pocket [chemical binding]; other site
688269002167	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cl00240
688269002168	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017
688269002169	Domain of unknown function (DUF205); Region: DUF205; cl00410
688269002170	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
688269002171	Sulfate transporter family; Region: Sulfate_transp; cl00967
688269002172	Permease family; Region: Xan_ur_permease; pfam00860
688269002173	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421
688269002174	purine monophosphate binding site [chemical binding]; other site
688269002175	dimer interface [polypeptide binding]; other site
688269002176	putative catalytic residues [active]
688269002177	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
688269002178	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688269002179	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
688269002180	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269002181	dimer interface [polypeptide binding]; other site
688269002182	conserved gate region; other site
688269002183	putative PBP binding loops; other site
688269002184	ABC-ATPase subunit interface; other site
688269002185	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
688269002186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269002187	dimer interface [polypeptide binding]; other site
688269002188	conserved gate region; other site
688269002189	putative PBP binding loops; other site
688269002190	ABC-ATPase subunit interface; other site
688269002191	UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082
688269002192	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
688269002193	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
688269002194	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
688269002195	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785
688269002196	active site
688269002197	homodimer interface [polypeptide binding]; other site
688269002198	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
688269002199	UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087
688269002200	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
688269002201	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
688269002202	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
688269002203	Entner-Doudoroff aldolase; Region: eda; TIGR01182
688269002204	active site
688269002205	intersubunit interface [polypeptide binding]; other site
688269002206	catalytic residue [active]
688269002207	competence damage-inducible protein A; Provisional; Region: PRK00549
688269002208	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
688269002209	putative MPT binding site; other site
688269002210	Competence-damaged protein; Region: CinA; cl00666
688269002211	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
688269002212	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
688269002213	putative binding surface; other site
688269002214	active site
688269002215	P2 response regulator binding domain; Region: P2; pfam07194
688269002216	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
688269002217	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688269002218	ATP binding site [chemical binding]; other site
688269002219	Mg2+ binding site [ion binding]; other site
688269002220	G-X-G motif; other site
688269002221	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
688269002222	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
688269002223	Response regulator receiver domain; Region: Response_reg; pfam00072
688269002224	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688269002225	active site
688269002226	phosphorylation site [posttranslational modification]
688269002227	intermolecular recognition site; other site
688269002228	dimerization interface [polypeptide binding]; other site
688269002229	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
688269002230	FliP family; Region: FliP; cl00593
688269002231	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
688269002232	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
688269002233	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017
688269002234	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
688269002235	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
688269002236	FHIPEP family; Region: FHIPEP; pfam00771
688269002237	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
688269002238	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
688269002239	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
688269002240	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
688269002241	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
688269002242	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
688269002243	Flagellar protein YcgR; Region: YcgR_2; pfam12945
688269002244	PilZ domain; Region: PilZ; cl01260
688269002245	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
688269002246	CheC-like family; Region: CheC; pfam04509
688269002247	CheC-like family; Region: CheC; pfam04509
688269002248	CheD chemotactic sensory transduction; Region: CheD; cl00810
688269002249	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
688269002250	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688269002251	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
688269002252	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
688269002253	DNA binding residues [nucleotide binding]
688269002254	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
688269002255	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
688269002256	DEAD-like helicases superfamily; Region: DEXDc; smart00487
688269002257	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
688269002258	ATP binding site [chemical binding]; other site
688269002259	putative Mg++ binding site [ion binding]; other site
688269002260	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688269002261	nucleotide binding region [chemical binding]; other site
688269002262	ATP-binding site [chemical binding]; other site
688269002263	TRCF domain; Region: TRCF; cl04088
688269002264	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
688269002265	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
688269002266	Ligand Binding Site [chemical binding]; other site
688269002267	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
688269002268	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
688269002269	active site
688269002270	metal binding site [ion binding]; metal-binding site
688269002271	homotetramer interface [polypeptide binding]; other site
688269002272	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
688269002273	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
688269002274	transcription termination factor Rho; Provisional; Region: rho; PRK09376
688269002275	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
688269002276	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459
688269002277	RNA binding site [nucleotide binding]; other site
688269002278	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128
688269002279	multimer interface [polypeptide binding]; other site
688269002280	Walker A motif; other site
688269002281	ATP binding site [chemical binding]; other site
688269002282	Walker B motif; other site
688269002283	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
688269002284	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
688269002285	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
688269002286	alphaNTD homodimer interface [polypeptide binding]; other site
688269002287	alphaNTD - beta interaction site [polypeptide binding]; other site
688269002288	alphaNTD - beta' interaction site [polypeptide binding]; other site
688269002289	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
688269002290	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
688269002291	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
688269002292	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
688269002293	RNA binding surface [nucleotide binding]; other site
688269002294	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
688269002295	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
688269002296	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
688269002297	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
688269002298	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
688269002299	rRNA binding site [nucleotide binding]; other site
688269002300	predicted 30S ribosome binding site; other site
688269002301	methionine aminopeptidase; Reviewed; Region: PRK07281
688269002302	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
688269002303	active site
688269002304	adenylate kinase; Reviewed; Region: adk; PRK00279
688269002305	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
688269002306	AMP-binding site [chemical binding]; other site
688269002307	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
688269002308	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
688269002309	SecY translocase; Region: SecY; pfam00344
688269002310	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
688269002311	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658
688269002312	23S rRNA binding site [nucleotide binding]; other site
688269002313	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
688269002314	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
688269002315	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
688269002316	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
688269002317	5S rRNA interface [nucleotide binding]; other site
688269002318	L27 interface [polypeptide binding]; other site
688269002319	23S rRNA interface [nucleotide binding]; other site
688269002320	L5 interface [polypeptide binding]; other site
688269002321	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
688269002322	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
688269002323	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
688269002324	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
688269002325	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
688269002326	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
688269002327	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
688269002328	KOW motif; Region: KOW; cl00354
688269002329	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
688269002330	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
688269002331	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427
688269002332	23S rRNA interface [nucleotide binding]; other site
688269002333	putative translocon interaction site; other site
688269002334	signal recognition particle (SRP54) interaction site; other site
688269002335	L23 interface [polypeptide binding]; other site
688269002336	trigger factor interaction site; other site
688269002337	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
688269002338	23S rRNA interface [nucleotide binding]; other site
688269002339	5S rRNA interface [nucleotide binding]; other site
688269002340	putative antibiotic binding site [chemical binding]; other site
688269002341	L25 interface [polypeptide binding]; other site
688269002342	L27 interface [polypeptide binding]; other site
688269002343	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
688269002344	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The...; Region: 30S_S3_KH; cd02412
688269002345	G-X-X-G motif; other site
688269002346	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
688269002347	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
688269002348	putative translocon binding site; other site
688269002349	protein-rRNA interface [nucleotide binding]; other site
688269002350	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
688269002351	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
688269002352	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
688269002353	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
688269002354	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
688269002355	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
688269002356	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
688269002357	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
688269002358	elongation factor Tu; Reviewed; Region: PRK00049
688269002359	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
688269002360	G1 box; other site
688269002361	GEF interaction site [polypeptide binding]; other site
688269002362	GTP/Mg2+ binding site [chemical binding]; other site
688269002363	Switch I region; other site
688269002364	G2 box; other site
688269002365	G3 box; other site
688269002366	Switch II region; other site
688269002367	G4 box; other site
688269002368	G5 box; other site
688269002369	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
688269002370	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
688269002371	Antibiotic Binding Site [chemical binding]; other site
688269002372	elongation factor G; Reviewed; Region: PRK00007
688269002373	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886
688269002374	G1 box; other site
688269002375	putative GEF interaction site [polypeptide binding]; other site
688269002376	GTP/Mg2+ binding site [chemical binding]; other site
688269002377	Switch I region; other site
688269002378	G2 box; other site
688269002379	G3 box; other site
688269002380	Switch II region; other site
688269002381	G4 box; other site
688269002382	G5 box; other site
688269002383	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088
688269002384	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434
688269002385	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713
688269002386	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
688269002387	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
688269002388	S17 interaction site [polypeptide binding]; other site
688269002389	S8 interaction site; other site
688269002390	16S rRNA interaction site [nucleotide binding]; other site
688269002391	streptomycin interaction site [chemical binding]; other site
688269002392	23S rRNA interaction site [nucleotide binding]; other site
688269002393	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
688269002394	hypothetical protein; Provisional; Region: PRK13670
688269002395	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
688269002396	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
688269002397	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
688269002398	GIY-YIG motif/motif A; other site
688269002399	active site
688269002400	catalytic site [active]
688269002401	putative DNA binding site [nucleotide binding]; other site
688269002402	metal binding site [ion binding]; metal-binding site
688269002403	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
688269002404	FeoA domain; Region: FeoA; cl00838
688269002405	FeoA domain; Region: FeoA; cl00838
688269002406	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
688269002407	Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions.  FeoB has been identified as part of this...; Region: FeoB; cd01879
688269002408	G1 box; other site
688269002409	GTP/Mg2+ binding site [chemical binding]; other site
688269002410	Switch I region; other site
688269002411	G2 box; other site
688269002412	G3 box; other site
688269002413	Switch II region; other site
688269002414	G4 box; other site
688269002415	G5 box; other site
688269002416	Nucleoside recognition; Region: Gate; cl00486
688269002417	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
688269002418	Nucleoside recognition; Region: Gate; cl00486
688269002419	Phosphate transporter family; Region: PHO4; cl00396
688269002420	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
688269002421	PhoU domain; Region: PhoU; pfam01895
688269002422	Protein of unknown function (DUF401); Region: DUF401; cl00830
688269002423	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
688269002424	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
688269002425	D-cysteine desulfhydrase; Validated; Region: PRK03910
688269002426	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342
688269002427	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
688269002428	catalytic residue [active]
688269002429	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
688269002430	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
688269002431	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
688269002432	putative tRNA-binding site [nucleotide binding]; other site
688269002433	B3/4 domain; Region: B3_4; cl11458
688269002434	tRNA synthetase B5 domain; Region: B5; cl08394
688269002435	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
688269002436	dimer interface [polypeptide binding]; other site
688269002437	motif 1; other site
688269002438	motif 3; other site
688269002439	motif 2; other site
688269002440	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
688269002441	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
688269002442	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
688269002443	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
688269002444	dimer interface [polypeptide binding]; other site
688269002445	motif 1; other site
688269002446	active site
688269002447	motif 2; other site
688269002448	motif 3; other site
688269002449	Radical SAM; Region: Elp3; smart00729
688269002450	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269002451	FeS/SAM binding site; other site
688269002452	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
688269002453	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593
688269002454	dimerization interface [polypeptide binding]; other site
688269002455	active site
688269002456	metal binding site [ion binding]; metal-binding site
688269002457	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048
688269002458	dsRNA binding site [nucleotide binding]; other site
688269002459	transketolase; Reviewed; Region: PRK05899
688269002460	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
688269002461	TPP-binding site [chemical binding]; other site
688269002462	dimer interface [polypeptide binding]; other site
688269002463	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
688269002464	PYR/PP interface [polypeptide binding]; other site
688269002465	dimer interface [polypeptide binding]; other site
688269002466	TPP binding site [chemical binding]; other site
688269002467	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
688269002468	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
688269002469	PSP1 C-terminal conserved region; Region: PSP1; cl00770
688269002470	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269002471	DNA polymerase III subunit delta'; Validated; Region: PRK06871
688269002472	Protein of unknown function (DUF327); Region: DUF327; cl00753
688269002473	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
688269002474	Initiation factor 2 subunit family; Region: IF-2B; pfam01008
688269002475	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
688269002476	PPIC-type PPIASE domain; Region: Rotamase; cl08278
688269002477	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
688269002478	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
688269002479	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
688269002480	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
688269002481	flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396
688269002482	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
688269002483	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
688269002484	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
688269002485	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
688269002486	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
688269002487	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
688269002488	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
688269002489	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
688269002490	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688269002491	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
688269002492	Catalytic site [active]
688269002493	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
688269002494	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
688269002495	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
688269002496	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
688269002497	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
688269002498	RimM N-terminal domain; Region: RimM; pfam01782
688269002499	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794
688269002500	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
688269002501	signal recognition particle protein; Provisional; Region: PRK10867
688269002502	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
688269002503	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
688269002504	P loop; other site
688269002505	GTP binding site [chemical binding]; other site
688269002506	Signal peptide binding domain; Region: SRP_SPB; pfam02978
688269002507	Protein of unknown function (DUF1343); Region: DUF1343; cl01598
688269002508	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
688269002509	4Fe-4S binding domain; Region: Fer4; cl02805
688269002510	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
688269002511	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
688269002512	Walker A/P-loop; other site
688269002513	ATP binding site [chemical binding]; other site
688269002514	Q-loop/lid; other site
688269002515	ABC transporter signature motif; other site
688269002516	Walker B; other site
688269002517	D-loop; other site
688269002518	H-loop/switch region; other site
688269002519	TOBE domain; Region: TOBE_2; cl01440
688269002520	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269002521	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
688269002522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269002523	dimer interface [polypeptide binding]; other site
688269002524	conserved gate region; other site
688269002525	putative PBP binding loops; other site
688269002526	ABC-ATPase subunit interface; other site
688269002527	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
688269002528	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269002529	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060
688269002530	AP (apurinic/apyrimidinic) site pocket; other site
688269002531	DNA interaction; other site
688269002532	Metal-binding active site; metal-binding site
688269002533	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
688269002534	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
688269002535	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
688269002536	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319
688269002537	active site
688269002538	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
688269002539	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
688269002540	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688269002541	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269002542	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
688269002543	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269002544	dimer interface [polypeptide binding]; other site
688269002545	conserved gate region; other site
688269002546	putative PBP binding loops; other site
688269002547	ABC-ATPase subunit interface; other site
688269002548	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
688269002549	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269002550	dimer interface [polypeptide binding]; other site
688269002551	conserved gate region; other site
688269002552	putative PBP binding loops; other site
688269002553	ABC-ATPase subunit interface; other site
688269002554	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
688269002555	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269002556	Walker A/P-loop; other site
688269002557	ATP binding site [chemical binding]; other site
688269002558	Q-loop/lid; other site
688269002559	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269002560	ABC transporter signature motif; other site
688269002561	Walker B; other site
688269002562	D-loop; other site
688269002563	H-loop/switch region; other site
688269002564	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
688269002565	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
688269002566	active site
688269002567	metal binding site [ion binding]; metal-binding site
688269002568	DNA binding site [nucleotide binding]
688269002569	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
688269002570	oligomerization interface [polypeptide binding]; other site
688269002571	active site
688269002572	metal binding site [ion binding]; metal-binding site
688269002573	Uncharacterized conserved protein [Function unknown]; Region: COG5495
688269002574	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269002575	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
688269002576	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
688269002577	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This...; Region: Alpha_ANH_like_II; cd01993
688269002578	Ligand Binding Site [chemical binding]; other site
688269002579	TIGR00269 family protein; Region: TIGR00269
688269002580	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
688269002581	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
688269002582	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-...; Region: DHOD_e_trans_like1; cd06219
688269002583	FAD binding pocket [chemical binding]; other site
688269002584	FAD binding motif [chemical binding]; other site
688269002585	phosphate binding motif [ion binding]; other site
688269002586	beta-alpha-beta structure motif; other site
688269002587	NAD binding pocket [chemical binding]; other site
688269002588	Iron coordination center [ion binding]; other site
688269002589	putative oxidoreductase; Provisional; Region: PRK12831
688269002590	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269002591	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
688269002592	active site
688269002593	metal binding site [ion binding]; metal-binding site
688269002594	homotetramer interface [polypeptide binding]; other site
688269002595	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
688269002596	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
688269002597	dimer interface [polypeptide binding]; other site
688269002598	active site
688269002599	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
688269002600	putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151
688269002601	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730
688269002602	FMN binding site [chemical binding]; other site
688269002603	substrate binding site [chemical binding]; other site
688269002604	putative catalytic residue [active]
688269002605	Acyl transferase domain; Region: Acyl_transf_1; cl08282
688269002606	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
688269002607	AMMECR1; Region: AMMECR1; cl00911
688269002608	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
688269002609	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269002610	FeS/SAM binding site; other site
688269002611	ApbE family; Region: ApbE; cl00643
688269002612	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846
688269002613	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973
688269002614	Maf-like protein; Region: Maf; pfam02545
688269002615	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
688269002616	active site
688269002617	dimer interface [polypeptide binding]; other site
688269002618	hypothetical protein; Reviewed; Region: PRK00024
688269002619	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
688269002620	MPN+ (JAMM) motif; other site
688269002621	Zinc-binding site [ion binding]; other site
688269002622	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688269002623	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
688269002624	intersubunit interface [polypeptide binding]; other site
688269002625	active site
688269002626	catalytic residue [active]
688269002627	Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350
688269002628	Queuine tRNA-ribosyltransferase; Region: TGT; cl00409
688269002629	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688269002630	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
688269002631	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14357
688269002632	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
688269002633	Substrate binding site [chemical binding]; other site
688269002634	Mg++ binding site [ion binding]; other site
688269002635	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
688269002636	active site
688269002637	substrate binding site [chemical binding]; other site
688269002638	CoA binding site [chemical binding]; other site
688269002639	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688269002640	ribose-phosphate pyrophosphokinase; Region: ribP_PPkin; TIGR01251
688269002641	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
688269002642	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
688269002643	5S rRNA interface [nucleotide binding]; other site
688269002644	CTC domain interface [polypeptide binding]; other site
688269002645	L16 interface [polypeptide binding]; other site
688269002646	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
688269002647	putative active site [active]
688269002648	catalytic residue [active]
688269002649	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
688269002650	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
688269002651	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
688269002652	active site
688269002653	metal binding site [ion binding]; metal-binding site
688269002654	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
688269002655	active site
688269002656	(T/H)XGH motif; other site
688269002657	elongation factor Ts; Reviewed; Region: tsf; PRK12332
688269002658	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
688269002659	Elongation factor TS; Region: EF_TS; pfam00889
688269002660	NurA domain; Region: NurA; cl09134
688269002661	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
688269002662	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
688269002663	active site
688269002664	metal binding site [ion binding]; metal-binding site
688269002665	homotetramer interface [polypeptide binding]; other site
688269002666	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
688269002667	ABC-2 type transporter; Region: ABC2_membrane; cl11417
688269002668	thymidylate kinase; Validated; Region: tmk; PRK00698
688269002669	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672
688269002670	TMP-binding site; other site
688269002671	ATP-binding site [chemical binding]; other site
688269002672	Acylphosphatase; Region: Acylphosphatase; cl00551
688269002673	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
688269002674	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
688269002675	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
688269002676	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381
688269002677	active site
688269002678	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
688269002679	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
688269002680	glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388
688269002681	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
688269002682	motif 1; other site
688269002683	dimer interface [polypeptide binding]; other site
688269002684	active site
688269002685	motif 2; other site
688269002686	motif 3; other site
688269002687	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
688269002688	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
688269002689	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
688269002690	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
688269002691	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
688269002692	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
688269002693	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
688269002694	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
688269002695	putative homodimer interface [polypeptide binding]; other site
688269002696	KOW motif; Region: KOW; cl00354
688269002697	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
688269002698	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
688269002699	23S rRNA interface [nucleotide binding]; other site
688269002700	L7/L12 interface [polypeptide binding]; other site
688269002701	putative thiostrepton binding site; other site
688269002702	L25 interface [polypeptide binding]; other site
688269002703	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403
688269002704	mRNA/rRNA interface [nucleotide binding]; other site
688269002705	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797
688269002706	23S rRNA interface [nucleotide binding]; other site
688269002707	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
688269002708	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
688269002709	core dimer interface [polypeptide binding]; other site
688269002710	peripheral dimer interface [polypeptide binding]; other site
688269002711	L10 interface [polypeptide binding]; other site
688269002712	L11 interface [polypeptide binding]; other site
688269002713	putative EF-Tu interaction site [polypeptide binding]; other site
688269002714	putative EF-G interaction site [polypeptide binding]; other site
688269002715	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
688269002716	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
688269002717	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591
688269002718	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
688269002719	RPB1 interaction site [polypeptide binding]; other site
688269002720	RPB10 interaction site [polypeptide binding]; other site
688269002721	RPB11 interaction site [polypeptide binding]; other site
688269002722	RPB3 interaction site [polypeptide binding]; other site
688269002723	RPB12 interaction site [polypeptide binding]; other site
688269002724	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
688269002725	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
688269002726	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
688269002727	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
688269002728	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
688269002729	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
688269002730	RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117
688269002731	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
688269002732	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
688269002733	G-loop; other site
688269002734	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
688269002735	DNA binding site [nucleotide binding]
688269002736	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
688269002737	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
688269002738	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688269002739	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
688269002740	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
688269002741	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
688269002742	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
688269002743	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
688269002744	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
688269002745	Walker A/P-loop; other site
688269002746	ATP binding site [chemical binding]; other site
688269002747	Q-loop/lid; other site
688269002748	ABC transporter signature motif; other site
688269002749	Walker B; other site
688269002750	D-loop; other site
688269002751	H-loop/switch region; other site
688269002752	DNA polymerase III subunit beta; Validated; Region: PRK05643
688269002753	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140
688269002754	putative DNA binding surface [nucleotide binding]; other site
688269002755	dimer interface [polypeptide binding]; other site
688269002756	beta-clamp/clamp loader binding surface; other site
688269002757	beta-clamp/translesion DNA polymerase binding surface; other site
688269002758	Restriction endonuclease; Region: Mrr_cat; cl00747
688269002759	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
688269002760	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
688269002761	Active_site [active]
688269002762	1,3-propanediol dehydrogenase-like (PPD); Region: PPD-like; cd08181
688269002763	dimer interface [polypeptide binding]; other site
688269002764	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
688269002765	active site
688269002766	metal binding site [ion binding]; metal-binding site
688269002767	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
688269002768	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688269002769	S-adenosylmethionine binding site [chemical binding]; other site
688269002770	aspartate aminotransferase; Provisional; Region: PRK06836
688269002771	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688269002772	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269002773	homodimer interface [polypeptide binding]; other site
688269002774	catalytic residue [active]
688269002775	integral membrane protein MviN; Region: mviN; TIGR01695
688269002776	MatE; Region: MatE; cl10513
688269002777	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
688269002778	putative ligand binding pocket/active site [active]
688269002779	putative metal binding site [ion binding]; other site
688269002780	Bacterial type II and III secretion system protein; Region: Secretin; cl02829
688269002781	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
688269002782	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
688269002783	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
688269002784	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
688269002785	RNA binding surface [nucleotide binding]; other site
688269002786	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
688269002787	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
688269002788	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817
688269002789	putative ADP-binding pocket [chemical binding]; other site
688269002790	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
688269002791	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
688269002792	C-terminal peptidase (prc); Region: prc; TIGR00225
688269002793	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
688269002794	protein binding site [polypeptide binding]; other site
688269002795	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
688269002796	Catalytic dyad [active]
688269002797	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
688269002798	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688269002799	S-adenosylmethionine binding site [chemical binding]; other site
688269002800	Sporulation and spore germination; Region: Germane; cl11253
688269002801	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
688269002802	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
688269002803	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
688269002804	Active site [active]
688269002805	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
688269002806	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
688269002807	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319
688269002808	active site
688269002809	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
688269002810	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688269002811	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
688269002812	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
688269002813	catalytic residue [active]
688269002814	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
688269002815	trimerization site [polypeptide binding]; other site
688269002816	active site
688269002817	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688269002818	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
688269002819	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
688269002820	catalytic residue [active]
688269002821	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
688269002822	trimerization site [polypeptide binding]; other site
688269002823	active site
688269002824	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
688269002825	ZIP Zinc transporter; Region: Zip; pfam02535
688269002826	dipeptidase PepV; Reviewed; Region: PRK07318
688269002827	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
688269002828	active site
688269002829	metal binding site [ion binding]; metal-binding site
688269002830	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
688269002831	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
688269002832	nucleotide binding pocket [chemical binding]; other site
688269002833	K-X-D-G motif; other site
688269002834	catalytic site [active]
688269002835	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
688269002836	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
688269002837	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
688269002838	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027
688269002839	Dimer interface [polypeptide binding]; other site
688269002840	BRCT sequence motif; other site
688269002841	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
688269002842	ArgK protein; Region: ArgK; pfam03308
688269002843	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
688269002844	Walker A; other site
688269002845	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
688269002846	G4 box; other site
688269002847	G5 box; other site
688269002848	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071
688269002849	B12 binding site [chemical binding]; other site
688269002850	cobalt ligand [ion binding]; other site
688269002851	Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884
688269002852	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
688269002853	Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856
688269002854	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
688269002855	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
688269002856	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
688269002857	dimer interface [polypeptide binding]; other site
688269002858	motif 1; other site
688269002859	active site
688269002860	motif 2; other site
688269002861	motif 3; other site
688269002862	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
688269002863	anticodon binding site; other site
688269002864	Uncharacterized Fe-S oxidoreductase [Energy production and conversion]; Region: COG1031
688269002865	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
688269002866	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
688269002867	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688269002868	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
688269002869	DNA binding residues [nucleotide binding]
688269002870	Protein of unknown function (DUF501); Region: DUF501; cl00652
688269002871	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
688269002872	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688269002873	S-adenosylmethionine binding site [chemical binding]; other site
688269002874	spermidine synthase; Provisional; Region: PRK00811
688269002875	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688269002876	S-adenosylmethionine binding site [chemical binding]; other site
688269002877	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
688269002878	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
688269002879	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
688269002880	non-specific DNA binding site [nucleotide binding]; other site
688269002881	salt bridge; other site
688269002882	sequence-specific DNA binding site [nucleotide binding]; other site
688269002883	Cupin domain; Region: Cupin_2; cl09118
688269002884	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
688269002885	catalytic motif [active]
688269002886	Zn binding site [ion binding]; other site
688269002887	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
688269002888	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
688269002889	TPP-binding site [chemical binding]; other site
688269002890	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
688269002891	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
688269002892	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
688269002893	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
688269002894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688269002895	active site
688269002896	phosphorylation site [posttranslational modification]
688269002897	intermolecular recognition site; other site
688269002898	dimerization interface [polypeptide binding]; other site
688269002899	CheB methylesterase; Region: CheB_methylest; pfam01339
688269002900	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
688269002901	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
688269002902	putative peptidoglycan binding site; other site
688269002903	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
688269002904	putative peptidoglycan binding site; other site
688269002905	Peptidase family M23; Region: Peptidase_M23; pfam01551
688269002906	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688269002907	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
688269002908	ribonuclease R; Region: RNase_R; TIGR02063
688269002909	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
688269002910	RNB domain; Region: RNB; pfam00773
688269002911	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471
688269002912	RNA binding site [nucleotide binding]; other site
688269002913	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269002914	Archaeal ATPase; Region: Arch_ATPase; pfam01637
688269002915	Walker A motif; other site
688269002916	ATP binding site [chemical binding]; other site
688269002917	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688269002918	metal binding site [ion binding]; metal-binding site
688269002919	active site
688269002920	I-site; other site
688269002921	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
688269002922	DHH family; Region: DHH; pfam01368
688269002923	DHHA1 domain; Region: DHHA1; pfam02272
688269002924	Flavin Reductases; Region: FlaRed; cl00801
688269002925	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
688269002926	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269002927	FeS/SAM binding site; other site
688269002928	HemN C-terminal region; Region: HemN_C; pfam06969
688269002929	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
688269002930	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
688269002931	GatB domain; Region: GatB_Yqey; cl11497
688269002932	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
688269002933	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
688269002934	Rhomboid family; Region: Rhomboid; cl11446
688269002935	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
688269002936	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998
688269002937	Ligand Binding Site [chemical binding]; other site
688269002938	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291
688269002939	CPxP  motif; other site
688269002940	YeeE/YedE family (DUF395); Region: DUF395; cl01018
688269002941	YeeE/YedE family (DUF395); Region: DUF395; cl01018
688269002942	DsrE/DsrF-like family; Region: DrsE; cl00672
688269002943	DsrE/DsrF-like family; Region: DrsE; cl00672
688269002944	DsrE/DsrF-like family; Region: DrsE; cl00672
688269002945	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
688269002946	dimerization interface [polypeptide binding]; other site
688269002947	putative DNA binding site [nucleotide binding]; other site
688269002948	putative Zn2+ binding site [ion binding]; other site
688269002949	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291
688269002950	CPxP  motif; other site
688269002951	Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934
688269002952	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895
688269002953	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
688269002954	Rhomboid family; Region: Rhomboid; cl11446
688269002955	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
688269002956	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
688269002957	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
688269002958	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269002959	dimer interface [polypeptide binding]; other site
688269002960	conserved gate region; other site
688269002961	putative PBP binding loops; other site
688269002962	ABC-ATPase subunit interface; other site
688269002963	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
688269002964	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
688269002965	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269002966	dimer interface [polypeptide binding]; other site
688269002967	conserved gate region; other site
688269002968	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269002969	ABC-ATPase subunit interface; other site
688269002970	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
688269002971	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688269002972	Walker A/P-loop; other site
688269002973	ATP binding site [chemical binding]; other site
688269002974	Q-loop/lid; other site
688269002975	ABC transporter signature motif; other site
688269002976	Walker B; other site
688269002977	D-loop; other site
688269002978	H-loop/switch region; other site
688269002979	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688269002980	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
688269002981	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688269002982	Walker A/P-loop; other site
688269002983	ATP binding site [chemical binding]; other site
688269002984	Q-loop/lid; other site
688269002985	ABC transporter signature motif; other site
688269002986	Walker B; other site
688269002987	D-loop; other site
688269002988	H-loop/switch region; other site
688269002989	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688269002990	H+ Antiporter protein; Region: 2A0121; TIGR00900
688269002991	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688269002992	putative substrate translocation pore; other site
688269002993	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
688269002994	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
688269002995	oligomer interface [polypeptide binding]; other site
688269002996	active site
688269002997	metal binding site [ion binding]; metal-binding site
688269002998	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
688269002999	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
688269003000	Walker A/P-loop; other site
688269003001	ATP binding site [chemical binding]; other site
688269003002	Q-loop/lid; other site
688269003003	ABC transporter signature motif; other site
688269003004	Walker B; other site
688269003005	D-loop; other site
688269003006	H-loop/switch region; other site
688269003007	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
688269003008	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
688269003009	putative active site [active]
688269003010	PhoH-like protein; Region: PhoH; cl12134
688269003011	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
688269003012	active site
688269003013	substrate binding site [chemical binding]; other site
688269003014	catalytic site [active]
688269003015	Mechanosensitive ion channel; Region: MS_channel; pfam00924
688269003016	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
688269003017	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688269003018	dimer interface [polypeptide binding]; other site
688269003019	phosphorylation site [posttranslational modification]
688269003020	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688269003021	ATP binding site [chemical binding]; other site
688269003022	Mg2+ binding site [ion binding]; other site
688269003023	G-X-G motif; other site
688269003024	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
688269003025	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688269003026	Ribosome-binding factor A; Region: RBFA; cl00542
688269003027	tRNA pseudouridine synthase B; Provisional; Region: PRK14124
688269003028	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573
688269003029	RNA binding site [nucleotide binding]; other site
688269003030	active site
688269003031	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
688269003032	active site
688269003033	nucleotide binding site [chemical binding]; other site
688269003034	HIGH motif; other site
688269003035	KMSKS motif; other site
688269003036	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
688269003037	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
688269003038	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
688269003039	Flagellin N-methylase; Region: FliB; cl00497
688269003040	Uncharacterized conserved protein [Function unknown]; Region: COG1751
688269003041	Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887
688269003042	Glucuronate isomerase; Region: UxaC; cl00829
688269003043	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
688269003044	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
688269003045	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
688269003046	dimer interface [polypeptide binding]; other site
688269003047	active site
688269003048	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
688269003049	substrate binding site [chemical binding]; other site
688269003050	catalytic residue [active]
688269003051	GTPase Era; Reviewed; Region: era; PRK00089
688269003052	Era subfamily.  Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria.  It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163
688269003053	G1 box; other site
688269003054	GTP/Mg2+ binding site [chemical binding]; other site
688269003055	Switch I region; other site
688269003056	G2 box; other site
688269003057	Switch II region; other site
688269003058	G3 box; other site
688269003059	G4 box; other site
688269003060	G5 box; other site
688269003061	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098
688269003062	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
688269003063	active site
688269003064	catalytic motif [active]
688269003065	Zn binding site [ion binding]; other site
688269003066	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
688269003067	Domain of unknown function DUF21; Region: DUF21; pfam01595
688269003068	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
688269003069	Transporter associated domain; Region: CorC_HlyC; cl08393
688269003070	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679
688269003071	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
688269003072	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296
688269003073	active site
688269003074	glutamate formiminotransferase; Region: FtcD; TIGR02024
688269003075	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
688269003076	Formiminotransferase domain; Region: FTCD; pfam02971
688269003077	Phd_YefM; Region: PhdYeFM; cl09153
688269003078	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
688269003079	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
688269003080	Walker A/P-loop; other site
688269003081	ATP binding site [chemical binding]; other site
688269003082	Q-loop/lid; other site
688269003083	ABC transporter signature motif; other site
688269003084	Walker B; other site
688269003085	D-loop; other site
688269003086	H-loop/switch region; other site
688269003087	TOBE domain; Region: TOBE_2; cl01440
688269003088	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144
688269003089	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
688269003090	cobalamin binding residues [chemical binding]; other site
688269003091	putative BtuC binding residues; other site
688269003092	dimer interface [polypeptide binding]; other site
688269003093	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
688269003094	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
688269003095	ABC-ATPase subunit  interface; other site
688269003096	dimer interface [polypeptide binding]; other site
688269003097	putative PBP binding regions; other site
688269003098	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
688269003099	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
688269003100	Walker A/P-loop; other site
688269003101	ATP binding site [chemical binding]; other site
688269003102	Q-loop/lid; other site
688269003103	ABC transporter signature motif; other site
688269003104	Walker B; other site
688269003105	D-loop; other site
688269003106	H-loop/switch region; other site
688269003107	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
688269003108	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
688269003109	Predicted dehydrogenase [General function prediction only]; Region: COG0579
688269003110	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
688269003111	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
688269003112	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
688269003113	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269003114	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cd00368
688269003115	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
688269003116	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
688269003117	glycerol kinase; Provisional; Region: glpK; PRK00047
688269003118	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
688269003119	N- and C-terminal domain interface [polypeptide binding]; other site
688269003120	active site
688269003121	MgATP binding site [chemical binding]; other site
688269003122	catalytic site [active]
688269003123	metal binding site [ion binding]; metal-binding site
688269003124	glycerol binding site [chemical binding]; other site
688269003125	homotetramer interface [polypeptide binding]; other site
688269003126	homodimer interface [polypeptide binding]; other site
688269003127	FBP binding site [chemical binding]; other site
688269003128	protein IIAGlc interface [polypeptide binding]; other site
688269003129	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
688269003130	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688269003131	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
688269003132	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269003133	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
688269003134	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
688269003135	classical (c) SDRs; Region: SDR_c; cd05233
688269003136	NAD(P) binding site [chemical binding]; other site
688269003137	active site
688269003138	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
688269003139	gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
688269003140	N- and C-terminal domain interface [polypeptide binding]; other site
688269003141	putative active site [active]
688269003142	catalytic site [active]
688269003143	metal binding site [ion binding]; metal-binding site
688269003144	carbohydrate binding site [chemical binding]; other site
688269003145	ATP binding site [chemical binding]; other site
688269003146	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
688269003147	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
688269003148	putative active site [active]
688269003149	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710
688269003150	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
688269003151	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269003152	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
688269003153	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
688269003154	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066
688269003155	active site
688269003156	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
688269003157	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
688269003158	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
688269003159	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
688269003160	Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359
688269003161	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
688269003162	active site
688269003163	substrate binding site [chemical binding]; other site
688269003164	catalytic site [active]
688269003165	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
688269003166	dimerization interface [polypeptide binding]; other site
688269003167	putative DNA binding site [nucleotide binding]; other site
688269003168	putative Zn2+ binding site [ion binding]; other site
688269003169	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
688269003170	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
688269003171	metal-binding site [ion binding]
688269003172	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
688269003173	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688269003174	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046
688269003175	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
688269003176	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688269003177	Major Facilitator Superfamily; Region: MFS_1; pfam07690
688269003178	putative substrate translocation pore; other site
688269003179	EamA-like transporter family; Region: EamA; cl01037
688269003180	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
688269003181	EamA-like transporter family; Region: EamA; cl01037
688269003182	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
688269003183	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
688269003184	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688269003185	Zn2+ binding site [ion binding]; other site
688269003186	Mg2+ binding site [ion binding]; other site
688269003187	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
688269003188	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
688269003189	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
688269003190	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
688269003191	putative deoxyribonuclease YjjV; Provisional; Region: PRK11449
688269003192	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
688269003193	active site
688269003194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688269003195	putative substrate translocation pore; other site
688269003196	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
688269003197	dimer interface [polypeptide binding]; other site
688269003198	motif 1; other site
688269003199	active site
688269003200	motif 2; other site
688269003201	motif 3; other site
688269003202	ATP phosphoribosyltransferase; Region: HisG; cl15266
688269003203	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
688269003204	E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572
688269003205	NAD binding site [chemical binding]; other site
688269003206	dimerization interface [polypeptide binding]; other site
688269003207	product binding site; other site
688269003208	substrate binding site [chemical binding]; other site
688269003209	zinc binding site [ion binding]; other site
688269003210	catalytic residues [active]
688269003211	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
688269003212	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688269003213	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269003214	homodimer interface [polypeptide binding]; other site
688269003215	catalytic residue [active]
688269003216	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
688269003217	putative active site pocket [active]
688269003218	4-fold oligomerization interface [polypeptide binding]; other site
688269003219	metal binding residues [ion binding]; metal-binding site
688269003220	3-fold/trimer interface [polypeptide binding]; other site
688269003221	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
688269003222	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
688269003223	putative active site [active]
688269003224	oxyanion strand; other site
688269003225	catalytic triad [active]
688269003226	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732
688269003227	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
688269003228	catalytic residues [active]
688269003229	Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107
688269003230	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731
688269003231	substrate binding site [chemical binding]; other site
688269003232	glutamase interaction surface [polypeptide binding]; other site
688269003233	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
688269003234	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
688269003235	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
688269003236	Predicted GTPase [General function prediction only]; Region: COG2403
688269003237	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14330
688269003238	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
688269003239	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269003240	FeS/SAM binding site; other site
688269003241	TRAM domain; Region: TRAM; cl01282
688269003242	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
688269003243	rRNA interaction site [nucleotide binding]; other site
688269003244	S8 interaction site; other site
688269003245	putative laminin-1 binding site; other site
688269003246	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
688269003247	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
688269003248	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
688269003249	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
688269003250	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
688269003251	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
688269003252	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
688269003253	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
688269003254	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
688269003255	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
688269003256	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
688269003257	reverse gyrase; Reviewed; Region: PRK09401
688269003258	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
688269003259	ATP binding site [chemical binding]; other site
688269003260	putative Mg++ binding site [ion binding]; other site
688269003261	TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove...; Region: TOPRIM_TopoIA_RevGyr; cd03361
688269003262	active site
688269003263	putative interdomain interaction site [polypeptide binding]; other site
688269003264	putative metal-binding site [ion binding]; other site
688269003265	putative nucleotide binding site [chemical binding]; other site
688269003266	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
688269003267	domain I; other site
688269003268	DNA binding groove [nucleotide binding]
688269003269	phosphate binding site [ion binding]; other site
688269003270	domain II; other site
688269003271	domain III; other site
688269003272	nucleotide binding site [chemical binding]; other site
688269003273	catalytic site [active]
688269003274	domain IV; other site
688269003275	Cupin domain; Region: Cupin_2; cl09118
688269003276	peptide chain release factor 2; Validated; Region: prfB; PRK00578
688269003277	RF-1 domain; Region: RF-1; cl02875
688269003278	RF-1 domain; Region: RF-1; cl02875
688269003279	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
688269003280	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
688269003281	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688269003282	nucleotide binding region [chemical binding]; other site
688269003283	ATP-binding site [chemical binding]; other site
688269003284	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
688269003285	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
688269003286	RNA binding surface [nucleotide binding]; other site
688269003287	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688269003288	tRNA pseudouridine synthase ACD; Provisional; Region: PRK14586
688269003289	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570
688269003290	dimerization interface 3.5A [polypeptide binding]; other site
688269003291	active site
688269003292	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
688269003293	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
688269003294	putative active site [active]
688269003295	substrate binding site [chemical binding]; other site
688269003296	putative cosubstrate binding site; other site
688269003297	catalytic site [active]
688269003298	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
688269003299	substrate binding site [chemical binding]; other site
688269003300	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487
688269003301	active site
688269003302	catalytic residues [active]
688269003303	metal binding site [ion binding]; metal-binding site
688269003304	Survival protein SurE; Region: SurE; cl00448
688269003305	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269003306	Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445
688269003307	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
688269003308	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688269003309	Zn2+ binding site [ion binding]; other site
688269003310	Mg2+ binding site [ion binding]; other site
688269003311	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
688269003312	synthetase active site [active]
688269003313	NTP binding site [chemical binding]; other site
688269003314	metal binding site [ion binding]; metal-binding site
688269003315	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668
688269003316	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563
688269003317	dimerization interface [polypeptide binding]; other site
688269003318	putative tRNAtyr binding site [nucleotide binding]; other site
688269003319	putative active site [active]
688269003320	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
688269003321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
688269003322	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269003323	Glucose inhibited division protein A; Region: GIDA; pfam01134
688269003324	Protein of unknown function (DUF342); Region: DUF342; pfam03961
688269003325	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
688269003326	Phosphopantetheine attachment site; Region: PP-binding; cl09936
688269003327	Cobalt transport protein; Region: CbiQ; cl00463
688269003328	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
688269003329	Tumour suppressor protein; Region: LOH1CR12; pfam10158
688269003330	Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256
688269003331	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193
688269003332	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
688269003333	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
688269003334	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
688269003335	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
688269003336	FliW protein; Region: FliW; cl00740
688269003337	Global regulator protein family; Region: CsrA; cl00670
688269003338	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
688269003339	Uncharacterised protein family UPF0102; Region: UPF0102; cl00516
688269003340	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
688269003341	SmpB-tmRNA interface; other site
688269003342	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
688269003343	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
688269003344	RNA binding surface [nucleotide binding]; other site
688269003345	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
688269003346	active site
688269003347	Zc3h12a-like Ribonuclease NYN domain; Region: RNase_Zc3h12a; pfam11977
688269003348	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
688269003349	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
688269003350	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
688269003351	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
688269003352	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
688269003353	Thiamine pyrophosphokinase; Region: TPK; cd07995
688269003354	active site
688269003355	dimerization interface [polypeptide binding]; other site
688269003356	thiamine binding site [chemical binding]; other site
688269003357	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
688269003358	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
688269003359	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
688269003360	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
688269003361	active site
688269003362	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989
688269003363	protein binding site [polypeptide binding]; other site
688269003364	RIP metalloprotease RseP; Region: TIGR00054
688269003365	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
688269003366	putative substrate binding region [chemical binding]; other site
688269003367	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
688269003368	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
688269003369	OsmC-like protein; Region: OsmC; cl00767
688269003370	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
688269003371	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269003372	NAD(P) binding site [chemical binding]; other site
688269003373	active site
688269003374	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
688269003375	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688269003376	DNA-binding site [nucleotide binding]; DNA binding site
688269003377	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
688269003378	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
688269003379	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
688269003380	NAD(P) binding site [chemical binding]; other site
688269003381	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
688269003382	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269003383	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
688269003384	Creatinine amidohydrolase; Region: Creatininase; cl00618
688269003385	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
688269003386	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
688269003387	putative ligand binding site [chemical binding]; other site
688269003388	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
688269003389	TM-ABC transporter signature motif; other site
688269003390	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
688269003391	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269003392	Walker A/P-loop; other site
688269003393	ATP binding site [chemical binding]; other site
688269003394	Q-loop/lid; other site
688269003395	ABC transporter signature motif; other site
688269003396	Walker B; other site
688269003397	D-loop; other site
688269003398	H-loop/switch region; other site
688269003399	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192
688269003400	substrate binding site [chemical binding]; other site
688269003401	ATP binding site [chemical binding]; other site
688269003402	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269003403	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
688269003404	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
688269003405	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269003406	dimer interface [polypeptide binding]; other site
688269003407	conserved gate region; other site
688269003408	putative PBP binding loops; other site
688269003409	ABC-ATPase subunit interface; other site
688269003410	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269003411	dimer interface [polypeptide binding]; other site
688269003412	conserved gate region; other site
688269003413	putative PBP binding loops; other site
688269003414	ABC-ATPase subunit interface; other site
688269003415	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
688269003416	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269003417	Walker A/P-loop; other site
688269003418	ATP binding site [chemical binding]; other site
688269003419	Q-loop/lid; other site
688269003420	ABC transporter signature motif; other site
688269003421	Walker B; other site
688269003422	D-loop; other site
688269003423	H-loop/switch region; other site
688269003424	TOBE domain; Region: TOBE_2; cl01440
688269003425	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688269003426	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
688269003427	active site
688269003428	motif I; other site
688269003429	motif II; other site
688269003430	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688269003431	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688269003432	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
688269003433	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060
688269003434	DNA interaction; other site
688269003435	Metal-binding active site; metal-binding site
688269003436	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269003437	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
688269003438	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269003439	dimer interface [polypeptide binding]; other site
688269003440	conserved gate region; other site
688269003441	putative PBP binding loops; other site
688269003442	ABC-ATPase subunit interface; other site
688269003443	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
688269003444	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269003445	dimer interface [polypeptide binding]; other site
688269003446	conserved gate region; other site
688269003447	putative PBP binding loops; other site
688269003448	ABC-ATPase subunit interface; other site
688269003449	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
688269003450	ABC Carbohydrate and Solute Transporters-like subgroup.  This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols.  ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259
688269003451	Walker A/P-loop; other site
688269003452	ATP binding site [chemical binding]; other site
688269003453	Q-loop/lid; other site
688269003454	ABC transporter signature motif; other site
688269003455	Walker B; other site
688269003456	D-loop; other site
688269003457	H-loop/switch region; other site
688269003458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688269003459	putative substrate translocation pore; other site
688269003460	Major Facilitator Superfamily; Region: MFS_1; pfam07690
688269003461	Transposase, Mutator family; Region: Transposase_mut; pfam00872
688269003462	MULE transposase domain; Region: MULE; pfam10551
688269003463	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688269003464	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
688269003465	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060
688269003466	DNA interaction; other site
688269003467	Metal-binding active site; metal-binding site
688269003468	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269003469	Transcriptional regulator [Transcription]; Region: IclR; COG1414
688269003470	Bacterial transcriptional regulator; Region: IclR; pfam01614
688269003471	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
688269003472	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
688269003473	substrate binding site [chemical binding]; other site
688269003474	ATP binding site [chemical binding]; other site
688269003475	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
688269003476	TM-ABC transporter signature motif; other site
688269003477	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
688269003478	TM-ABC transporter signature motif; other site
688269003479	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
688269003480	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
688269003481	Walker A/P-loop; other site
688269003482	ATP binding site [chemical binding]; other site
688269003483	Q-loop/lid; other site
688269003484	ABC transporter signature motif; other site
688269003485	Walker B; other site
688269003486	D-loop; other site
688269003487	H-loop/switch region; other site
688269003488	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
688269003489	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
688269003490	Walker A/P-loop; other site
688269003491	ATP binding site [chemical binding]; other site
688269003492	Q-loop/lid; other site
688269003493	ABC transporter signature motif; other site
688269003494	Walker B; other site
688269003495	D-loop; other site
688269003496	H-loop/switch region; other site
688269003497	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269003498	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
688269003499	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
688269003500	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
688269003501	uncharacterized xylulose kinase-like proteins, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
688269003502	N- and C-terminal domain interface [polypeptide binding]; other site
688269003503	putative active site [active]
688269003504	catalytic site [active]
688269003505	metal binding site [ion binding]; metal-binding site
688269003506	putative xylulose binding site [chemical binding]; other site
688269003507	putative ATP binding site [chemical binding]; other site
688269003508	putative homodimer interface [polypeptide binding]; other site
688269003509	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269003510	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
688269003511	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
688269003512	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269003513	dimer interface [polypeptide binding]; other site
688269003514	conserved gate region; other site
688269003515	putative PBP binding loops; other site
688269003516	ABC-ATPase subunit interface; other site
688269003517	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688269003518	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269003519	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269003520	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214
688269003521	intersubunit interface [polypeptide binding]; other site
688269003522	active site
688269003523	Zn2+ binding site [ion binding]; other site
688269003524	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
688269003525	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
688269003526	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
688269003527	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
688269003528	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
688269003529	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
688269003530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269003531	dimer interface [polypeptide binding]; other site
688269003532	conserved gate region; other site
688269003533	putative PBP binding loops; other site
688269003534	ABC-ATPase subunit interface; other site
688269003535	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
688269003536	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269003537	dimer interface [polypeptide binding]; other site
688269003538	conserved gate region; other site
688269003539	putative PBP binding loops; other site
688269003540	ABC-ATPase subunit interface; other site
688269003541	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl06815
688269003542	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688269003543	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269003544	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
688269003545	substrate binding site [chemical binding]; other site
688269003546	Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616
688269003547	active site
688269003548	L-arabinose isomerase; Provisional; Region: PRK02929
688269003549	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
688269003550	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
688269003551	trimer interface [polypeptide binding]; other site
688269003552	putative substrate binding site [chemical binding]; other site
688269003553	putative metal binding site [ion binding]; other site
688269003554	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688269003555	DNA-binding site [nucleotide binding]; DNA binding site
688269003556	Transcriptional regulators [Transcription]; Region: PurR; COG1609
688269003557	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
688269003558	Domain of unknown function (DUF368); Region: DUF368; cl00893
688269003559	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688269003560	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
688269003561	substrate binding pocket [chemical binding]; other site
688269003562	membrane-bound complex binding site; other site
688269003563	hinge residues; other site
688269003564	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
688269003565	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262
688269003566	Walker A/P-loop; other site
688269003567	ATP binding site [chemical binding]; other site
688269003568	Q-loop/lid; other site
688269003569	ABC transporter signature motif; other site
688269003570	Walker B; other site
688269003571	D-loop; other site
688269003572	H-loop/switch region; other site
688269003573	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
688269003574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269003575	dimer interface [polypeptide binding]; other site
688269003576	conserved gate region; other site
688269003577	putative PBP binding loops; other site
688269003578	ABC-ATPase subunit interface; other site
688269003579	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
688269003580	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
688269003581	catalytic loop [active]
688269003582	iron binding site [ion binding]; other site
688269003583	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868
688269003584	FAD binding pocket [chemical binding]; other site
688269003585	conserved FAD binding motif [chemical binding]; other site
688269003586	phosphate binding motif [ion binding]; other site
688269003587	beta-alpha-beta structure motif; other site
688269003588	NAD binding pocket [chemical binding]; other site
688269003589	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
688269003590	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
688269003591	FMN-binding domain; Region: FMN_bind; cl01081
688269003592	RnfE family; Region: NQR2_RnfD_RnfE; cl00779
688269003593	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688269003594	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
688269003595	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688269003596	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
688269003597	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
688269003598	HflK protein; Region: hflK; TIGR01933
688269003599	HflK protein; Region: hflK; TIGR01933
688269003600	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
688269003601	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
688269003602	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688269003603	motif II; other site
688269003604	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
688269003605	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
688269003606	putative NAD(P) binding site [chemical binding]; other site
688269003607	structural Zn binding site [ion binding]; other site
688269003608	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839
688269003609	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
688269003610	DNA binding residues [nucleotide binding]
688269003611	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742
688269003612	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
688269003613	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
688269003614	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693
688269003615	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
688269003616	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269003617	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
688269003618	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
688269003619	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
688269003620	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
688269003621	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
688269003622	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
688269003623	active site
688269003624	NTP binding site [chemical binding]; other site
688269003625	metal binding triad [ion binding]; metal-binding site
688269003626	antibiotic binding site [chemical binding]; other site
688269003627	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495
688269003628	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
688269003629	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679
688269003630	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
688269003631	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
688269003632	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
688269003633	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634
688269003634	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634
688269003635	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
688269003636	CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749
688269003637	CRISPR/Cas system-associated RAMP superfamily protein Cmr6; Region: Cmr6_III-B; cd09661
688269003638	CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578
688269003639	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688269003640	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622
688269003641	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
688269003642	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
688269003643	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
688269003644	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732
688269003645	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784
688269003646	potential frameshift: common BLAST hit: gi|307154088|ref|YP_003889472.1| PBS lyase HEAT domain-containing protein repeat-containing protein
688269003647	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
688269003648	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
688269003649	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
688269003650	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
688269003651	Archaeal ATPase; Region: Arch_ATPase; pfam01637
688269003652	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269003653	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
688269003654	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
688269003655	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688269003656	motif II; other site
688269003657	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
688269003658	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
688269003659	active site
688269003660	Zn binding site [ion binding]; other site
688269003661	Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577
688269003662	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
688269003663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688269003664	active site
688269003665	phosphorylation site [posttranslational modification]
688269003666	intermolecular recognition site; other site
688269003667	dimerization interface [polypeptide binding]; other site
688269003668	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
688269003669	DNA binding site [nucleotide binding]
688269003670	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
688269003671	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688269003672	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688269003673	dimer interface [polypeptide binding]; other site
688269003674	phosphorylation site [posttranslational modification]
688269003675	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688269003676	ATP binding site [chemical binding]; other site
688269003677	Mg2+ binding site [ion binding]; other site
688269003678	G-X-G motif; other site
688269003679	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
688269003680	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269003681	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
688269003682	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
688269003683	Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973
688269003684	catalytic residues [active]
688269003685	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
688269003686	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
688269003687	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
688269003688	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688269003689	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
688269003690	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
688269003691	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688269003692	active site
688269003693	motif I; other site
688269003694	motif II; other site
688269003695	ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597
688269003696	YqeH.  YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855
688269003697	GTP/Mg2+ binding site [chemical binding]; other site
688269003698	G4 box; other site
688269003699	G5 box; other site
688269003700	G1 box; other site
688269003701	Switch I region; other site
688269003702	G2 box; other site
688269003703	G3 box; other site
688269003704	Switch II region; other site
688269003705	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
688269003706	Propanediol utilisation protein PduL; Region: PduL; pfam06130
688269003707	Propanediol utilisation protein PduL; Region: PduL; pfam06130
688269003708	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
688269003709	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
688269003710	metal binding site [ion binding]; metal-binding site
688269003711	dimer interface [polypeptide binding]; other site
688269003712	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
688269003713	putative active site [active]
688269003714	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269003715	Cache domain; Region: Cache_1; pfam02743
688269003716	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
688269003717	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
688269003718	dimerization interface [polypeptide binding]; other site
688269003719	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
688269003720	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
688269003721	active site
688269003722	tetramer interface [polypeptide binding]; other site
688269003723	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
688269003724	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
688269003725	ligand binding site [chemical binding]; other site
688269003726	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
688269003727	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
688269003728	Walker A/P-loop; other site
688269003729	ATP binding site [chemical binding]; other site
688269003730	Q-loop/lid; other site
688269003731	ABC transporter signature motif; other site
688269003732	Walker B; other site
688269003733	D-loop; other site
688269003734	H-loop/switch region; other site
688269003735	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
688269003736	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
688269003737	TM-ABC transporter signature motif; other site
688269003738	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
688269003739	TM-ABC transporter signature motif; other site
688269003740	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
688269003741	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
688269003742	RNA binding surface [nucleotide binding]; other site
688269003743	PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553
688269003744	active site
688269003745	uracil binding [chemical binding]; other site
688269003746	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
688269003747	ligand binding site [chemical binding]; other site
688269003748	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
688269003749	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
688269003750	Walker A/P-loop; other site
688269003751	ATP binding site [chemical binding]; other site
688269003752	Q-loop/lid; other site
688269003753	ABC transporter signature motif; other site
688269003754	Walker B; other site
688269003755	D-loop; other site
688269003756	H-loop/switch region; other site
688269003757	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
688269003758	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
688269003759	TM-ABC transporter signature motif; other site
688269003760	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
688269003761	TM-ABC transporter signature motif; other site
688269003762	cell division protein FtsA; Region: ftsA; TIGR01174
688269003763	Cell division protein FtsA; Region: FtsA; cl11496
688269003764	Cell division protein FtsA; Region: FtsA; cl11496
688269003765	early DNA-binding protein E2A; Provisional; Region: PHA03384
688269003766	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
688269003767	MutS2 homologs in bacteria and eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280
688269003768	Walker A/P-loop; other site
688269003769	ATP binding site [chemical binding]; other site
688269003770	Q-loop/lid; other site
688269003771	ABC transporter signature motif; other site
688269003772	Walker B; other site
688269003773	D-loop; other site
688269003774	H-loop/switch region; other site
688269003775	Smr domain; Region: Smr; cl02619
688269003776	GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157
688269003777	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
688269003778	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
688269003779	Walker A motif; other site
688269003780	ATP binding site [chemical binding]; other site
688269003781	Walker B motif; other site
688269003782	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201
688269003783	nucleotide binding site [chemical binding]; other site
688269003784	SulA interaction site; other site
688269003785	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
688269003786	Cell division protein FtsA; Region: FtsA; cl11496
688269003787	Cell division protein FtsA; Region: FtsA; cl11496
688269003788	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
688269003789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688269003790	ATP binding site [chemical binding]; other site
688269003791	Mg2+ binding site [ion binding]; other site
688269003792	G-X-G motif; other site
688269003793	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
688269003794	anchoring element; other site
688269003795	dimer interface [polypeptide binding]; other site
688269003796	ATP binding site [chemical binding]; other site
688269003797	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366
688269003798	active site
688269003799	putative metal-binding site [ion binding]; other site
688269003800	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
688269003801	Protein of unknown function (DUF721); Region: DUF721; cl02324
688269003802	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449
688269003803	homodimer interface [polypeptide binding]; other site
688269003804	substrate-cofactor binding pocket; other site
688269003805	Aminotransferase class IV; Region: Aminotran_4; pfam01063
688269003806	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269003807	catalytic residue [active]
688269003808	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
688269003809	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
688269003810	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269003811	FeS/SAM binding site; other site
688269003812	FOG: CBS domain [General function prediction only]; Region: COG0517
688269003813	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
688269003814	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
688269003815	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
688269003816	putative substrate binding site [chemical binding]; other site
688269003817	putative ATP binding site [chemical binding]; other site
688269003818	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
688269003819	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269003820	Walker A/P-loop; other site
688269003821	ATP binding site [chemical binding]; other site
688269003822	Q-loop/lid; other site
688269003823	ABC transporter signature motif; other site
688269003824	Walker B; other site
688269003825	D-loop; other site
688269003826	H-loop/switch region; other site
688269003827	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688269003828	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688269003829	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
688269003830	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688269003831	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269003832	Walker A motif; other site
688269003833	ATP binding site [chemical binding]; other site
688269003834	Walker B motif; other site
688269003835	arginine finger; other site
688269003836	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
688269003837	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688269003838	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688269003839	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688269003840	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688269003841	hypothetical protein; Validated; Region: PRK06840
688269003842	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
688269003843	active site
688269003844	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
688269003845	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
688269003846	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
688269003847	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
688269003848	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
688269003849	NAD(P) binding site [chemical binding]; other site
688269003850	homotetramer interface [polypeptide binding]; other site
688269003851	homodimer interface [polypeptide binding]; other site
688269003852	active site
688269003853	putative acyltransferase; Provisional; Region: PRK05790
688269003854	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
688269003855	dimer interface [polypeptide binding]; other site
688269003856	active site
688269003857	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
688269003858	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
688269003859	putative ligand binding site [chemical binding]; other site
688269003860	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
688269003861	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
688269003862	Walker A/P-loop; other site
688269003863	ATP binding site [chemical binding]; other site
688269003864	Q-loop/lid; other site
688269003865	ABC transporter signature motif; other site
688269003866	Walker B; other site
688269003867	D-loop; other site
688269003868	H-loop/switch region; other site
688269003869	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
688269003870	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
688269003871	Walker A/P-loop; other site
688269003872	ATP binding site [chemical binding]; other site
688269003873	Q-loop/lid; other site
688269003874	ABC transporter signature motif; other site
688269003875	Walker B; other site
688269003876	D-loop; other site
688269003877	H-loop/switch region; other site
688269003878	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
688269003879	TM-ABC transporter signature motif; other site
688269003880	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
688269003881	TM-ABC transporter signature motif; other site
688269003882	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
688269003883	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
688269003884	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
688269003885	dimer interface [polypeptide binding]; other site
688269003886	active site
688269003887	CoA binding pocket [chemical binding]; other site
688269003888	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
688269003889	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688269003890	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
688269003891	EamA-like transporter family; Region: EamA; cl01037
688269003892	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
688269003893	EamA-like transporter family; Region: EamA; cl01037
688269003894	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688269003895	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
688269003896	active site
688269003897	motif I; other site
688269003898	motif II; other site
688269003899	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
688269003900	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
688269003901	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
688269003902	putative active site [active]
688269003903	catalytic triad [active]
688269003904	putative dimer interface [polypeptide binding]; other site
688269003905	Sulfatase; Region: Sulfatase; cl10460
688269003906	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
688269003907	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
688269003908	metal ion-dependent adhesion site (MIDAS); other site
688269003909	Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005
688269003910	Protein of unknown function (DUF996); Region: DUF996; cl00970
688269003911	Transposase, Mutator family; Region: Transposase_mut; pfam00872
688269003912	MULE transposase domain; Region: MULE; pfam10551
688269003913	hypothetical protein; Validated; Region: PRK07682
688269003914	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688269003915	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269003916	homodimer interface [polypeptide binding]; other site
688269003917	catalytic residue [active]
688269003918	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
688269003919	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
688269003920	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269003921	Walker A/P-loop; other site
688269003922	ATP binding site [chemical binding]; other site
688269003923	Q-loop/lid; other site
688269003924	ABC transporter signature motif; other site
688269003925	Walker B; other site
688269003926	D-loop; other site
688269003927	H-loop/switch region; other site
688269003928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688269003929	S-adenosylmethionine binding site [chemical binding]; other site
688269003930	Acetokinase family; Region: Acetate_kinase; cl01029
688269003931	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
688269003932	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
688269003933	ferredoxin; Validated; Region: PRK07118
688269003934	Putative Fe-S cluster; Region: FeS; pfam04060
688269003935	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
688269003936	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
688269003937	FMN-binding domain; Region: FMN_bind; cl01081
688269003938	RnfE family; Region: NQR2_RnfD_RnfE; cl00779
688269003939	C subunit; Region: rnfC; TIGR01945
688269003940	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
688269003941	SLBB domain; Region: SLBB; pfam10531
688269003942	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
688269003943	Biotin synthase-related enzyme [General function prediction only]; Region: COG2516
688269003944	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269003945	FeS/SAM binding site; other site
688269003946	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
688269003947	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
688269003948	ligand binding site [chemical binding]; other site
688269003949	oligomer interface [polypeptide binding]; other site
688269003950	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651
688269003951	dimer interface [polypeptide binding]; other site
688269003952	N-terminal domain interface [polypeptide binding]; other site
688269003953	sulfate 1 binding site; other site
688269003954	ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448
688269003955	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
688269003956	ligand binding site [chemical binding]; other site
688269003957	oligomer interface [polypeptide binding]; other site
688269003958	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651
688269003959	dimer interface [polypeptide binding]; other site
688269003960	N-terminal domain interface [polypeptide binding]; other site
688269003961	sulfate 1 binding site; other site
688269003962	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
688269003963	YlqF.  Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856
688269003964	GTP/Mg2+ binding site [chemical binding]; other site
688269003965	G4 box; other site
688269003966	G5 box; other site
688269003967	G1 box; other site
688269003968	Switch I region; other site
688269003969	G2 box; other site
688269003970	G3 box; other site
688269003971	Switch II region; other site
688269003972	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
688269003973	binding surface
688269003974	TPR motif; other site
688269003975	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
688269003976	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
688269003977	binding surface
688269003978	TPR motif; other site
688269003979	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
688269003980	TPR motif; other site
688269003981	binding surface
688269003982	Sulfatase; Region: Sulfatase; cl10460
688269003983	2,3-bisphosphoglycerate-independent phosphoglycerate mutase, archaeal form; Region: apgM; TIGR00306
688269003984	Competence protein; Region: Competence; cl00471
688269003985	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
688269003986	metal binding site 2 [ion binding]; metal-binding site
688269003987	putative DNA binding helix; other site
688269003988	metal binding site 1 [ion binding]; metal-binding site
688269003989	dimer interface [polypeptide binding]; other site
688269003990	structural Zn2+ binding site [ion binding]; other site
688269003991	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
688269003992	NusA N-terminal domain; Region: NusA_N; pfam08529
688269003993	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455
688269003994	RNA binding site [nucleotide binding]; other site
688269003995	homodimer interface [polypeptide binding]; other site
688269003996	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
688269003997	G-X-X-G motif; other site
688269003998	Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983
688269003999	YcfA-like protein; Region: YcfA; cl00752
688269004000	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes...; Region: NADPH_oxidoreductase_1; cd02150
688269004001	putative FMN binding site [chemical binding]; other site
688269004002	EamA-like transporter family; Region: EamA; cl01037
688269004003	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
688269004004	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049
688269004005	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
688269004006	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
688269004007	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
688269004008	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688269004009	phosphodiesterase; Provisional; Region: PRK12704
688269004010	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
688269004011	PhoH-like protein; Region: PhoH; cl12134
688269004012	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
688269004013	Isoamylase N-terminus domain. Isoamylase (aka glycogen 6-glucanohydrolase) is one of the starch-debranching enzymes that catalyzes the hydrolysis of alpha-1,6-glucosidic linkages specific in alpha-glucans such as amylopectin or glycogen. Isoamylase...; Region: Isoamylase_N_term; cd02852
688269004014	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
688269004015	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
688269004016	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293
688269004017	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
688269004018	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
688269004019	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269004020	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
688269004021	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
688269004022	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
688269004023	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269004024	dimer interface [polypeptide binding]; other site
688269004025	conserved gate region; other site
688269004026	putative PBP binding loops; other site
688269004027	ABC-ATPase subunit interface; other site
688269004028	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
688269004029	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
688269004030	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269004031	dimer interface [polypeptide binding]; other site
688269004032	conserved gate region; other site
688269004033	putative PBP binding loops; other site
688269004034	ABC-ATPase subunit interface; other site
688269004035	NlpC/P60 family; Region: NLPC_P60; cl11438
688269004036	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
688269004037	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688269004038	Walker A/P-loop; other site
688269004039	ATP binding site [chemical binding]; other site
688269004040	Q-loop/lid; other site
688269004041	ABC transporter signature motif; other site
688269004042	Walker B; other site
688269004043	D-loop; other site
688269004044	H-loop/switch region; other site
688269004045	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688269004046	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
688269004047	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
688269004048	active site
688269004049	putative substrate binding pocket [chemical binding]; other site
688269004050	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
688269004051	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769
688269004052	SxDxEG motif; other site
688269004053	putative active site [active]
688269004054	putative metal binding site [ion binding]; other site
688269004055	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688269004056	transmembrane helices; other site
688269004057	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293
688269004058	B12 binding site [chemical binding]; other site
688269004059	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688269004060	transmembrane helices; other site
688269004061	Glucose inhibited division protein A; Region: GIDA; pfam01134
688269004062	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269004063	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
688269004064	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
688269004065	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
688269004066	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688269004067	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
688269004068	homotrimer interaction site [polypeptide binding]; other site
688269004069	putative active site [active]
688269004070	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
688269004071	YheO-like PAS domain; Region: PAS_6; pfam08348
688269004072	Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674
688269004073	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
688269004074	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
688269004075	metal binding site [ion binding]; metal-binding site
688269004076	dimer interface [polypeptide binding]; other site
688269004077	oxaloacetate decarboxylase; Provisional; Region: PRK14041
688269004078	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
688269004079	active site
688269004080	catalytic residues [active]
688269004081	metal binding site [ion binding]; metal-binding site
688269004082	homodimer binding site [polypeptide binding]; other site
688269004083	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
688269004084	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
688269004085	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
688269004086	catalytic center binding site [active]
688269004087	ATP binding site [chemical binding]; other site
688269004088	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
688269004089	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
688269004090	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
688269004091	NAD(P) binding site [chemical binding]; other site
688269004092	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
688269004093	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
688269004094	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
688269004095	NAD(P) binding site [chemical binding]; other site
688269004096	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
688269004097	putative metal binding site [ion binding]; other site
688269004098	flagellin; Reviewed; Region: PRK08869
688269004099	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
688269004100	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
688269004101	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
688269004102	putative trimer interface [polypeptide binding]; other site
688269004103	putative CoA binding site [chemical binding]; other site
688269004104	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
688269004105	putative trimer interface [polypeptide binding]; other site
688269004106	putative active site [active]
688269004107	putative substrate binding site [chemical binding]; other site
688269004108	putative CoA binding site [chemical binding]; other site
688269004109	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
688269004110	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
688269004111	active site
688269004112	NTP binding site [chemical binding]; other site
688269004113	metal binding triad [ion binding]; metal-binding site
688269004114	antibiotic binding site [chemical binding]; other site
688269004115	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
688269004116	Transposase, Mutator family; Region: Transposase_mut; pfam00872
688269004117	MULE transposase domain; Region: MULE; pfam10551
688269004118	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
688269004119	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688269004120	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
688269004121	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
688269004122	dimer interface [polypeptide binding]; other site
688269004123	active site
688269004124	galactokinase; Provisional; Region: PRK03817
688269004125	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
688269004126	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
688269004127	Cache domain; Region: Cache_1; pfam02743
688269004128	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688269004129	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688269004130	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
688269004131	Bacterial Ig-like domain (group 1); Region: Big_1; cl10510
688269004132	Clostripain family; Region: Peptidase_C11; cl04055
688269004133	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
688269004134	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
688269004135	ligand binding site [chemical binding]; other site
688269004136	flexible hinge region; other site
688269004137	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269004138	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
688269004139	4Fe-4S binding domain; Region: Fer4; cl02805
688269004140	hybrid cluster protein; Provisional; Region: PRK05290
688269004141	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
688269004142	ACS interaction site; other site
688269004143	CODH interaction site; other site
688269004144	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
688269004145	hybrid metal cluster; other site
688269004146	Predicted dehydrogenase [General function prediction only]; Region: COG0579
688269004147	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881
688269004148	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
688269004149	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269004150	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
688269004151	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269004152	NAD(P) binding pocket [chemical binding]; other site
688269004153	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928
688269004154	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
688269004155	uncharacterized ygcE-like proteins, N-terminal domain; Region: FGGY_ygcE_like; cd07779
688269004156	putative N- and C-terminal domain interface [polypeptide binding]; other site
688269004157	putative active site [active]
688269004158	putative MgATP binding site [chemical binding]; other site
688269004159	catalytic site [active]
688269004160	metal binding site [ion binding]; metal-binding site
688269004161	putative carbohydrate binding site [chemical binding]; other site
688269004162	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
688269004163	FAD binding domain; Region: FAD_binding_4; pfam01565
688269004164	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
688269004165	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688269004166	DNA-binding site [nucleotide binding]; DNA binding site
688269004167	UTRA domain; Region: UTRA; cl01230
688269004168	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
688269004169	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
688269004170	dimer interface [polypeptide binding]; other site
688269004171	active site
688269004172	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
688269004173	dimer interface [polypeptide binding]; other site
688269004174	active site
688269004175	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192
688269004176	bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427
688269004177	substrate binding site [chemical binding]; other site
688269004178	ATP binding site [chemical binding]; other site
688269004179	Archaeal phosphomethylpyrimidine kinase; Region: MethylPyrKinase; cl00871
688269004180	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
688269004181	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060
688269004182	Metal-binding active site; metal-binding site
688269004183	AP (apurinic/apyrimidinic) site pocket; other site
688269004184	ThiC family; Region: ThiC; cl08031
688269004185	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269004186	Ribulose 1,5-bisphosphate synthetase, converts PRPP to RuBP, flavoprotein [Carbohydrate    transport and metabolism]; Region: THI4; COG1635
688269004187	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
688269004188	FtsX-like permease family; Region: FtsX; pfam02687
688269004189	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
688269004190	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
688269004191	Walker A/P-loop; other site
688269004192	ATP binding site [chemical binding]; other site
688269004193	Q-loop/lid; other site
688269004194	ABC transporter signature motif; other site
688269004195	Walker B; other site
688269004196	D-loop; other site
688269004197	H-loop/switch region; other site
688269004198	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
688269004199	DNA photolyase; Region: DNA_photolyase; pfam00875
688269004200	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
688269004201	serine/threonine dehydratase; Validated; Region: PRK07048
688269004202	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
688269004203	tetramer interface [polypeptide binding]; other site
688269004204	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269004205	catalytic residue [active]
688269004206	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
688269004207	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
688269004208	Malic enzyme, N-terminal domain; Region: malic; pfam00390
688269004209	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
688269004210	putative NAD(P) binding site [chemical binding]; other site
688269004211	Uncharacterized conserved protein [Function unknown]; Region: COG3875
688269004212	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
688269004213	MOFRL family; Region: MOFRL; cl01013
688269004214	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
688269004215	Interdomain contacts; other site
688269004216	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
688269004217	gluconate transporter; Region: gntP; TIGR00791
688269004218	GntP family permease; Region: GntP_permease; cl15264
688269004219	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688269004220	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269004221	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
688269004222	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269004223	dimer interface [polypeptide binding]; other site
688269004224	conserved gate region; other site
688269004225	putative PBP binding loops; other site
688269004226	ABC-ATPase subunit interface; other site
688269004227	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
688269004228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269004229	Transcriptional regulators [Transcription]; Region: PurR; COG1609
688269004230	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
688269004231	DNA binding site [nucleotide binding]
688269004232	domain linker motif; other site
688269004233	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
688269004234	dimerization interface [polypeptide binding]; other site
688269004235	ligand binding site [chemical binding]; other site
688269004236	potential frameshift: common BLAST hit: gi|217967672|ref|YP_002353178.1| lipoprotein
688269004237	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
688269004238	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
688269004239	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
688269004240	active site
688269004241	NTP binding site [chemical binding]; other site
688269004242	metal binding triad [ion binding]; metal-binding site
688269004243	antibiotic binding site [chemical binding]; other site
688269004244	potential frameshift: common BLAST hit: gi|20090613|ref|NP_616688.1| cell surface protein
688269004245	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
688269004246	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
688269004247	The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; Region: Luminal_IRE1_like; cl14874
688269004248	homodimer interface [polypeptide binding]; other site
688269004249	FOG: WD40-like repeat [Function unknown]; Region: COG1520
688269004250	Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493
688269004251	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
688269004252	Protein of unknown function (DUF499); Region: DUF499; pfam04465
688269004253	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
688269004254	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
688269004255	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688269004256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688269004257	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
688269004258	ATP binding site [chemical binding]; other site
688269004259	putative Mg++ binding site [ion binding]; other site
688269004260	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688269004261	nucleotide binding region [chemical binding]; other site
688269004262	ATP-binding site [chemical binding]; other site
688269004263	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
688269004264	dimer interface [polypeptide binding]; other site
688269004265	substrate binding site [chemical binding]; other site
688269004266	metal binding sites [ion binding]; metal-binding site
688269004267	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
688269004268	nucleotide binding site/active site [active]
688269004269	HIT family signature motif; other site
688269004270	catalytic residue [active]
688269004271	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
688269004272	active site
688269004273	NTP binding site [chemical binding]; other site
688269004274	metal binding triad [ion binding]; metal-binding site
688269004275	antibiotic binding site [chemical binding]; other site
688269004276	HEPN domain; Region: HEPN; cl00824
688269004277	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
688269004278	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269004279	putative PBP binding loops; other site
688269004280	dimer interface [polypeptide binding]; other site
688269004281	ABC-ATPase subunit interface; other site
688269004282	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269004283	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
688269004284	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
688269004285	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
688269004286	nucleophile elbow; other site
688269004287	GAF domain; Region: GAF; cl00853
688269004288	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688269004289	metal binding site [ion binding]; metal-binding site
688269004290	active site
688269004291	I-site; other site
688269004292	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
688269004293	THUMP domain; Region: THUMP; cl12076
688269004294	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
688269004295	Ligand Binding Site [chemical binding]; other site
688269004296	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
688269004297	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
688269004298	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
688269004299	catalytic residue [active]
688269004300	Protein of unknown function (DUF996); Region: DUF996; cl00970
688269004301	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
688269004302	Protein export membrane protein; Region: SecD_SecF; cl14618
688269004303	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
688269004304	aspartate racemase; Region: asp_race; TIGR00035
688269004305	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750
688269004306	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
688269004307	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
688269004308	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
688269004309	O-Antigen ligase; Region: Wzy_C; cl04850
688269004310	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
688269004311	tetramerization interface [polypeptide binding]; other site
688269004312	active site
688269004313	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
688269004314	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688269004315	Coenzyme A binding pocket [chemical binding]; other site
688269004316	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
688269004317	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
688269004318	DNA-binding site [nucleotide binding]; DNA binding site
688269004319	RNA-binding motif; other site
688269004320	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK13951
688269004321	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
688269004322	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
688269004323	NAD binding site [chemical binding]; other site
688269004324	sugar binding site [chemical binding]; other site
688269004325	divalent metal binding site [ion binding]; other site
688269004326	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
688269004327	dimer interface [polypeptide binding]; other site
688269004328	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041
688269004329	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041
688269004330	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
688269004331	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
688269004332	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
688269004333	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269004334	Isochorismatase family; Region: Isochorismatase; pfam00857
688269004335	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
688269004336	catalytic triad [active]
688269004337	conserved cis-peptide bond; other site
688269004338	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688269004339	metal binding site [ion binding]; metal-binding site
688269004340	active site
688269004341	I-site; other site
688269004342	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
688269004343	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
688269004344	putative substrate binding site [chemical binding]; other site
688269004345	putative ATP binding site [chemical binding]; other site
688269004346	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214
688269004347	intersubunit interface [polypeptide binding]; other site
688269004348	active site
688269004349	Zn2+ binding site [ion binding]; other site
688269004350	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
688269004351	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
688269004352	active site
688269004353	metal binding site [ion binding]; metal-binding site
688269004354	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
688269004355	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269004356	Chromate transporter; Region: Chromate_transp; pfam02417
688269004357	Chromate transporter; Region: Chromate_transp; pfam02417
688269004358	Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047
688269004359	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
688269004360	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
688269004361	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
688269004362	active site
688269004363	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
688269004364	dimer interface [polypeptide binding]; other site
688269004365	active site
688269004366	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
688269004367	dimer interface [polypeptide binding]; other site
688269004368	active site
688269004369	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
688269004370	N subunit; Region: benz_CoA_bzdN; cl11464
688269004371	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
688269004372	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
688269004373	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
688269004374	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
688269004375	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688269004376	motif II; other site
688269004377	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
688269004378	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
688269004379	dimer interface [polypeptide binding]; other site
688269004380	ssDNA binding site [nucleotide binding]; other site
688269004381	tetramer (dimer of dimers) interface [polypeptide binding]; other site
688269004382	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
688269004383	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
688269004384	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
688269004385	putative substrate binding site [chemical binding]; other site
688269004386	nucleotide binding site [chemical binding]; other site
688269004387	nucleotide binding site [chemical binding]; other site
688269004388	homodimer interface [polypeptide binding]; other site
688269004389	Uncharacterized conserved protein [Function unknown]; Region: COG5276
688269004390	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688269004391	metal binding site [ion binding]; metal-binding site
688269004392	active site
688269004393	I-site; other site
688269004394	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369
688269004395	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
688269004396	hinge; other site
688269004397	active site
688269004398	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
688269004399	PEGA domain; Region: PEGA; pfam08308
688269004400	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
688269004401	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
688269004402	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
688269004403	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
688269004404	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688269004405	DNA-binding site [nucleotide binding]; DNA binding site
688269004406	Transcriptional regulators [Transcription]; Region: PurR; COG1609
688269004407	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
688269004408	dimerization interface [polypeptide binding]; other site
688269004409	ligand binding site [chemical binding]; other site
688269004410	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688269004411	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269004412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269004413	dimer interface [polypeptide binding]; other site
688269004414	conserved gate region; other site
688269004415	putative PBP binding loops; other site
688269004416	ABC-ATPase subunit interface; other site
688269004417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269004418	dimer interface [polypeptide binding]; other site
688269004419	conserved gate region; other site
688269004420	putative PBP binding loops; other site
688269004421	ABC-ATPase subunit interface; other site
688269004422	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
688269004423	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269004424	Walker A/P-loop; other site
688269004425	ATP binding site [chemical binding]; other site
688269004426	Q-loop/lid; other site
688269004427	ABC transporter signature motif; other site
688269004428	Walker B; other site
688269004429	D-loop; other site
688269004430	H-loop/switch region; other site
688269004431	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
688269004432	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
688269004433	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4878
688269004434	Predicted membrane protein [Function unknown]; Region: COG4267
688269004435	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_3; cd03813
688269004436	GAF domain; Region: GAF; cl00853
688269004437	TM1410 hypothetical-related protein; Region: DUF297; cl00997
688269004438	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
688269004439	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
688269004440	Cache domain; Region: Cache_1; pfam02743
688269004441	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
688269004442	dimerization interface [polypeptide binding]; other site
688269004443	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
688269004444	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
688269004445	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
688269004446	active site
688269004447	catalytic tetrad [active]
688269004448	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
688269004449	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
688269004450	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
688269004451	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269004452	Walker A motif; other site
688269004453	ATP binding site [chemical binding]; other site
688269004454	Walker B motif; other site
688269004455	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
688269004456	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
688269004457	Sodium:neurotransmitter symporter family; Region: SNF; cl11976
688269004458	Predicted transcriptional regulators [Transcription]; Region: COG1318
688269004459	probable regulatory domain; Region: near_KaiC_dom; TIGR03879
688269004460	hypothetical protein; Provisional; Region: PRK04328
688269004461	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
688269004462	Walker A motif; other site
688269004463	ATP binding site [chemical binding]; other site
688269004464	Walker B motif; other site
688269004465	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269004466	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
688269004467	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269004468	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269004469	dimer interface [polypeptide binding]; other site
688269004470	conserved gate region; other site
688269004471	putative PBP binding loops; other site
688269004472	ABC-ATPase subunit interface; other site
688269004473	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
688269004474	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269004475	dimer interface [polypeptide binding]; other site
688269004476	conserved gate region; other site
688269004477	putative PBP binding loops; other site
688269004478	ABC-ATPase subunit interface; other site
688269004479	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
688269004480	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
688269004481	binding surface
688269004482	TPR motif; other site
688269004483	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
688269004484	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
688269004485	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799
688269004486	active site
688269004487	substrate binding site [chemical binding]; other site
688269004488	metal binding site [ion binding]; metal-binding site
688269004489	aspartate aminotransferase; Provisional; Region: PRK08361
688269004490	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688269004491	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269004492	homodimer interface [polypeptide binding]; other site
688269004493	catalytic residue [active]
688269004494	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
688269004495	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688269004496	Coenzyme A binding pocket [chemical binding]; other site
688269004497	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269004498	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
688269004499	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688269004500	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293
688269004501	Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to L-threo-; Region: Glm_e; cl02025
688269004502	homodimer (epsilon-epsilon) interface [polypeptide binding]; other site
688269004503	B12 cofactor binding site [chemical binding]; other site
688269004504	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
688269004505	Predicted methyltransferases [General function prediction only]; Region: COG1568
688269004506	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688269004507	S-adenosylmethionine binding site [chemical binding]; other site
688269004508	histidinol-phosphatase; Provisional; Region: PRK05588
688269004509	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
688269004510	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
688269004511	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
688269004512	NAD binding site [chemical binding]; other site
688269004513	dimer interface [polypeptide binding]; other site
688269004514	substrate binding site [chemical binding]; other site
688269004515	tetramer (dimer of dimers) interface [polypeptide binding]; other site
688269004516	Protein of unknown function (DUF523); Region: DUF523; cl00733
688269004517	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
688269004518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688269004519	spermidine synthase; Provisional; Region: PRK00811
688269004520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688269004521	S-adenosylmethionine binding site [chemical binding]; other site
688269004522	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
688269004523	dimer interface [polypeptide binding]; other site
688269004524	substrate binding site [chemical binding]; other site
688269004525	metal binding site [ion binding]; metal-binding site
688269004526	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
688269004527	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
688269004528	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
688269004529	NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00196
688269004530	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
688269004531	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
688269004532	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
688269004533	Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
688269004534	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12579
688269004535	Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676
688269004536	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
688269004537	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
688269004538	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12667
688269004539	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
688269004540	Carbon starvation protein CstA; Region: CstA; cl00856
688269004541	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
688269004542	ABC-ATPase subunit  interface; other site
688269004543	dimer interface [polypeptide binding]; other site
688269004544	putative PBP binding regions; other site
688269004545	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
688269004546	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235
688269004547	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
688269004548	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
688269004549	intersubunit interface [polypeptide binding]; other site
688269004550	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
688269004551	metal binding site 2 [ion binding]; metal-binding site
688269004552	putative DNA binding helix; other site
688269004553	metal binding site 1 [ion binding]; metal-binding site
688269004554	dimer interface [polypeptide binding]; other site
688269004555	structural Zn2+ binding site [ion binding]; other site
688269004556	aspartate aminotransferase; Provisional; Region: PRK08361
688269004557	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688269004558	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269004559	homodimer interface [polypeptide binding]; other site
688269004560	catalytic residue [active]
688269004561	argininosuccinate synthase; Provisional; Region: PLN00200
688269004562	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
688269004563	ANP binding site [chemical binding]; other site
688269004564	Substrate Binding Site II [chemical binding]; other site
688269004565	Substrate Binding Site I [chemical binding]; other site
688269004566	Lyase; Region: Lyase_1; pfam00206
688269004567	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
688269004568	active sites [active]
688269004569	tetramer interface [polypeptide binding]; other site
688269004570	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
688269004571	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269004572	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
688269004573	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152
688269004574	heterotetramer interface [polypeptide binding]; other site
688269004575	active site pocket [active]
688269004576	cleavage site
688269004577	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250
688269004578	feedback inhibition sensing region; other site
688269004579	homohexameric interface [polypeptide binding]; other site
688269004580	nucleotide binding site [chemical binding]; other site
688269004581	N-acetyl-L-glutamate binding site [chemical binding]; other site
688269004582	acetylornithine aminotransferase; Provisional; Region: PRK02627
688269004583	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
688269004584	inhibitor-cofactor binding pocket; inhibition site
688269004585	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269004586	catalytic residue [active]
688269004587	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
688269004588	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
688269004589	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
688269004590	catalytic site [active]
688269004591	subunit interface [polypeptide binding]; other site
688269004592	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
688269004593	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
688269004594	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688269004595	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
688269004596	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
688269004597	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688269004598	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
688269004599	substrate binding site [chemical binding]; other site
688269004600	Transcriptional regulators [Transcription]; Region: PurR; COG1609
688269004601	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
688269004602	DNA binding site [nucleotide binding]
688269004603	domain linker motif; other site
688269004604	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
688269004605	ligand binding site [chemical binding]; other site
688269004606	dimerization interface [polypeptide binding]; other site
688269004607	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688269004608	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269004609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269004610	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269004611	dimer interface [polypeptide binding]; other site
688269004612	conserved gate region; other site
688269004613	putative PBP binding loops; other site
688269004614	ABC-ATPase subunit interface; other site
688269004615	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
688269004616	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269004617	dimer interface [polypeptide binding]; other site
688269004618	conserved gate region; other site
688269004619	putative PBP binding loops; other site
688269004620	ABC-ATPase subunit interface; other site
688269004621	beta-phosphoglucomutase; Region: bPGM; TIGR01990
688269004622	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688269004623	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
688269004624	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
688269004625	Transcriptional regulators [Transcription]; Region: PurR; COG1609
688269004626	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
688269004627	DNA binding site [nucleotide binding]
688269004628	domain linker motif; other site
688269004629	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
688269004630	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688269004631	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269004632	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
688269004633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269004634	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269004635	dimer interface [polypeptide binding]; other site
688269004636	putative PBP binding loops; other site
688269004637	ABC-ATPase subunit interface; other site
688269004638	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
688269004639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269004640	dimer interface [polypeptide binding]; other site
688269004641	conserved gate region; other site
688269004642	putative PBP binding loops; other site
688269004643	ABC-ATPase subunit interface; other site
688269004644	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
688269004645	active site
688269004646	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
688269004647	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
688269004648	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
688269004649	MgtE intracellular N domain; Region: MgtE_N; cl15244
688269004650	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
688269004651	Divalent cation transporter; Region: MgtE; cl00786
688269004652	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
688269004653	SUA5 domain; Region: SUA5; pfam03481
688269004654	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064
688269004655	putative dimer interface [polypeptide binding]; other site
688269004656	[2Fe-2S] cluster binding site [ion binding]; other site
688269004657	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980
688269004658	dimer interface [polypeptide binding]; other site
688269004659	[2Fe-2S] cluster binding site [ion binding]; other site
688269004660	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980
688269004661	dimer interface [polypeptide binding]; other site
688269004662	[2Fe-2S] cluster binding site [ion binding]; other site
688269004663	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
688269004664	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
688269004665	SLBB domain; Region: SLBB; pfam10531
688269004666	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
688269004667	4Fe-4S binding domain; Region: Fer4; cl02805
688269004668	hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512
688269004669	NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958
688269004670	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064
688269004671	putative dimer interface [polypeptide binding]; other site
688269004672	[2Fe-2S] cluster binding site [ion binding]; other site
688269004673	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980
688269004674	dimer interface [polypeptide binding]; other site
688269004675	[2Fe-2S] cluster binding site [ion binding]; other site
688269004676	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
688269004677	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
688269004678	SLBB domain; Region: SLBB; pfam10531
688269004679	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
688269004680	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
688269004681	ScpA/B protein; Region: ScpA_ScpB; cl00598
688269004682	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
688269004683	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
688269004684	active site
688269004685	HIGH motif; other site
688269004686	dimer interface [polypeptide binding]; other site
688269004687	KMSKS motif; other site
688269004688	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
688269004689	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269004690	NAD(P) binding pocket [chemical binding]; other site
688269004691	Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268
688269004692	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
688269004693	Potassium binding sites [ion binding]; other site
688269004694	Cesium cation binding sites [ion binding]; other site
688269004695	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223
688269004696	putative RNA binding site [nucleotide binding]; other site
688269004697	Protein of unknown function (DUF322); Region: DUF322; cl00574
688269004698	elongation factor P; Validated; Region: PRK00529
688269004699	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
688269004700	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470
688269004701	RNA binding site [nucleotide binding]; other site
688269004702	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794
688269004703	RNA binding site [nucleotide binding]; other site
688269004704	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
688269004705	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
688269004706	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
688269004707	active site
688269004708	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
688269004709	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
688269004710	minor groove reading motif; other site
688269004711	helix-hairpin-helix signature motif; other site
688269004712	substrate binding pocket [chemical binding]; other site
688269004713	active site
688269004714	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
688269004715	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
688269004716	RNA/DNA hybrid binding site [nucleotide binding]; other site
688269004717	active site
688269004718	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
688269004719	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688269004720	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
688269004721	Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion...; Region: SORL_classII; cd03172
688269004722	non-heme iron binding site [ion binding]; other site
688269004723	tetramer interface [polypeptide binding]; other site
688269004724	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688269004725	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
688269004726	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688269004727	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
688269004728	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
688269004729	active site
688269004730	metal binding site [ion binding]; metal-binding site
688269004731	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
688269004732	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
688269004733	Protein of unknown function DUF58; Region: DUF58; pfam01882
688269004734	MoxR-like ATPases [General function prediction only]; Region: COG0714
688269004735	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269004736	Walker A motif; other site
688269004737	ATP binding site [chemical binding]; other site
688269004738	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269004739	Walker B motif; other site
688269004740	arginine finger; other site
688269004741	Phosphate transporter family; Region: PHO4; cl00396
688269004742	Alkaline phosphatase homologues; Region: alkPPc; smart00098
688269004743	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cd00016
688269004744	active site
688269004745	dimer interface [polypeptide binding]; other site
688269004746	Uncharacterized conserved protein [Function unknown]; Region: COG2461
688269004747	Family of unknown function (DUF438); Region: DUF438; pfam04282
688269004748	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399
688269004749	active site
688269004750	trimer interface [polypeptide binding]; other site
688269004751	allosteric site; other site
688269004752	active site lid [active]
688269004753	hexamer (dimer of trimers) interface [polypeptide binding]; other site
688269004754	Protein of unknown function DUF86; Region: DUF86; cl01031
688269004755	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
688269004756	active site
688269004757	NTP binding site [chemical binding]; other site
688269004758	metal binding triad [ion binding]; metal-binding site
688269004759	antibiotic binding site [chemical binding]; other site
688269004760	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105
688269004761	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
688269004762	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
688269004763	NAD binding site [chemical binding]; other site
688269004764	sugar binding site [chemical binding]; other site
688269004765	divalent metal binding site [ion binding]; other site
688269004766	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
688269004767	dimer interface [polypeptide binding]; other site
688269004768	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
688269004769	MatE; Region: MatE; cl10513
688269004770	MatE; Region: MatE; cl10513
688269004771	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
688269004772	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688269004773	substrate binding pocket [chemical binding]; other site
688269004774	membrane-bound complex binding site; other site
688269004775	hinge residues; other site
688269004776	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
688269004777	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688269004778	Zn2+ binding site [ion binding]; other site
688269004779	Mg2+ binding site [ion binding]; other site
688269004780	MatE; Region: MatE; cl10513
688269004781	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
688269004782	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
688269004783	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
688269004784	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (; Region: GT1_wlbH_like; cd03798
688269004785	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
688269004786	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
688269004787	active site
688269004788	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
688269004789	homodimer interface [polypeptide binding]; other site
688269004790	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
688269004791	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
688269004792	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
688269004793	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
688269004794	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
688269004795	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
688269004796	putative ADP-binding pocket [chemical binding]; other site
688269004797	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
688269004798	Bacterial sugar transferase; Region: Bac_transf; cl00939
688269004799	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
688269004800	Chain length determinant protein; Region: Wzz; cl01623
688269004801	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
688269004802	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
688269004803	SLBB domain; Region: SLBB; pfam10531
688269004804	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
688269004805	active site
688269004806	NTP binding site [chemical binding]; other site
688269004807	metal binding triad [ion binding]; metal-binding site
688269004808	antibiotic binding site [chemical binding]; other site
688269004809	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
688269004810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688269004811	S-adenosylmethionine binding site [chemical binding]; other site
688269004812	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688269004813	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
688269004814	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269004815	dimer interface [polypeptide binding]; other site
688269004816	conserved gate region; other site
688269004817	putative PBP binding loops; other site
688269004818	ABC-ATPase subunit interface; other site
688269004819	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
688269004820	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269004821	dimer interface [polypeptide binding]; other site
688269004822	conserved gate region; other site
688269004823	putative PBP binding loops; other site
688269004824	ABC-ATPase subunit interface; other site
688269004825	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
688269004826	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
688269004827	Walker A/P-loop; other site
688269004828	ATP binding site [chemical binding]; other site
688269004829	Q-loop/lid; other site
688269004830	ABC transporter signature motif; other site
688269004831	Walker B; other site
688269004832	D-loop; other site
688269004833	H-loop/switch region; other site
688269004834	TOBE domain; Region: TOBE_2; cl01440
688269004835	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
688269004836	active site
688269004837	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
688269004838	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
688269004839	putative active site [active]
688269004840	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
688269004841	VanZ like family; Region: VanZ; cl01971
688269004842	Domain of unknown function DUF77; Region: DUF77; cl00307
688269004843	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
688269004844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269004845	NMT1/THI5 like; Region: NMT1; pfam09084
688269004846	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293
688269004847	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
688269004848	Walker A/P-loop; other site
688269004849	ATP binding site [chemical binding]; other site
688269004850	Q-loop/lid; other site
688269004851	ABC transporter signature motif; other site
688269004852	Walker B; other site
688269004853	D-loop; other site
688269004854	H-loop/switch region; other site
688269004855	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
688269004856	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
688269004857	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
688269004858	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
688269004859	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
688269004860	putative ligand binding site [chemical binding]; other site
688269004861	DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005
688269004862	Ca binding site [ion binding]; other site
688269004863	carbohydrate binding site [chemical binding]; other site
688269004864	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
688269004865	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
688269004866	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
688269004867	domain; Region: Glyco_hydro_2; pfam00703
688269004868	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895
688269004869	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
688269004870	Transposase, Mutator family; Region: Transposase_mut; pfam00872
688269004871	MULE transposase domain; Region: MULE; pfam10551
688269004872	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl12019
688269004873	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
688269004874	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
688269004875	catalytic motif [active]
688269004876	Zn binding site [ion binding]; other site
688269004877	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
688269004878	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
688269004879	Lumazine binding domain; Region: Lum_binding; pfam00677
688269004880	Lumazine binding domain; Region: Lum_binding; pfam00677
688269004881	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
688269004882	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
688269004883	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
688269004884	dimerization interface [polypeptide binding]; other site
688269004885	active site
688269004886	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
688269004887	homopentamer interface [polypeptide binding]; other site
688269004888	active site
688269004889	Transposase, Mutator family; Region: Transposase_mut; pfam00872
688269004890	MULE transposase domain; Region: MULE; pfam10551
688269004891	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
688269004892	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
688269004893	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515
688269004894	S-layer homology domain; Region: SLH; pfam00395
688269004895	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
688269004896	FOG: CBS domain [General function prediction only]; Region: COG0517
688269004897	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
688269004898	PEGA domain; Region: PEGA; pfam08308
688269004899	PEGA domain; Region: PEGA; pfam08308
688269004900	PEGA domain; Region: PEGA; pfam08308
688269004901	PEGA domain; Region: PEGA; pfam08308
688269004902	PEGA domain; Region: PEGA; pfam08308
688269004903	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
688269004904	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
688269004905	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
688269004906	protein binding site [polypeptide binding]; other site
688269004907	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
688269004908	protein binding site [polypeptide binding]; other site
688269004909	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
688269004910	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
688269004911	FMN binding site [chemical binding]; other site
688269004912	active site
688269004913	catalytic residues [active]
688269004914	substrate binding site [chemical binding]; other site
688269004915	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
688269004916	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
688269004917	active site
688269004918	(T/H)XGH motif; other site
688269004919	GTPase CgtA; Reviewed; Region: obgE; PRK12297
688269004920	GTP1/OBG; Region: GTP1_OBG; pfam01018
688269004921	Obg subfamily.  The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation.  Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898
688269004922	G1 box; other site
688269004923	GTP/Mg2+ binding site [chemical binding]; other site
688269004924	Switch I region; other site
688269004925	G2 box; other site
688269004926	G3 box; other site
688269004927	Switch II region; other site
688269004928	G4 box; other site
688269004929	G5 box; other site
688269004930	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
688269004931	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
688269004932	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060
688269004933	AP (apurinic/apyrimidinic) site pocket; other site
688269004934	DNA interaction; other site
688269004935	Metal-binding active site; metal-binding site
688269004936	Peptidase family C69; Region: Peptidase_C69; cl01920
688269004937	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
688269004938	Protein of unknown function DUF82; Region: DUF82; pfam01927
688269004939	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
688269004940	GAF domain; Region: GAF; cl00853
688269004941	GAF domain; Region: GAF; cl00853
688269004942	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
688269004943	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
688269004944	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
688269004945	dimer interface [polypeptide binding]; other site
688269004946	phosphorylation site [posttranslational modification]
688269004947	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
688269004948	ATP binding site [chemical binding]; other site
688269004949	Mg2+ binding site [ion binding]; other site
688269004950	G-X-G motif; other site
688269004951	Response regulator receiver domain; Region: Response_reg; pfam00072
688269004952	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688269004953	active site
688269004954	phosphorylation site [posttranslational modification]
688269004955	intermolecular recognition site; other site
688269004956	dimerization interface [polypeptide binding]; other site
688269004957	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
688269004958	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
688269004959	active site
688269004960	HIGH motif; other site
688269004961	nucleotide binding site [chemical binding]; other site
688269004962	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
688269004963	active site
688269004964	KMSKS motif; other site
688269004965	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
688269004966	tRNA binding surface [nucleotide binding]; other site
688269004967	anticodon binding site; other site
688269004968	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
688269004969	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
688269004970	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
688269004971	Walker A motif; other site
688269004972	ATP binding site [chemical binding]; other site
688269004973	Walker B motif; other site
688269004974	peptide chain release factor 1; Validated; Region: prfA; PRK00591
688269004975	RF-1 domain; Region: RF-1; cl02875
688269004976	RF-1 domain; Region: RF-1; cl02875
688269004977	Rod binding protein; Region: Rod-binding; cl01626
688269004978	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
688269004979	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
688269004980	Flagellar L-ring protein; Region: FlgH; cl00905
688269004981	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK08515
688269004982	SAF domain; Region: SAF; cl00555
688269004983	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
688269004984	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
688269004985	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
688269004986	fagellar hook-basal body proteins; Region: FlgEFG_subfam; TIGR03506
688269004987	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
688269004988	rod shape-determining protein MreB; Provisional; Region: PRK13930
688269004989	Cell division protein FtsA; Region: FtsA; cl11496
688269004990	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
688269004991	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
688269004992	DHH family; Region: DHH; pfam01368
688269004993	DHHA1 domain; Region: DHHA1; pfam02272
688269004994	benzoate transport; Region: 2A0115; TIGR00895
688269004995	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688269004996	putative substrate translocation pore; other site
688269004997	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
688269004998	Nucleoside recognition; Region: Gate; cl00486
688269004999	urocanate hydratase; Provisional; Region: PRK05414
688269005000	urocanate hydratase; Region: hutU; TIGR01228
688269005001	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
688269005002	active site
688269005003	NTP binding site [chemical binding]; other site
688269005004	metal binding triad [ion binding]; metal-binding site
688269005005	antibiotic binding site [chemical binding]; other site
688269005006	Protein of unknown function DUF86; Region: DUF86; cl01031
688269005007	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
688269005008	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
688269005009	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
688269005010	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
688269005011	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
688269005012	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
688269005013	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
688269005014	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
688269005015	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
688269005016	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269005017	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
688269005018	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
688269005019	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
688269005020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269005021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269005022	dimer interface [polypeptide binding]; other site
688269005023	conserved gate region; other site
688269005024	putative PBP binding loops; other site
688269005025	ABC-ATPase subunit interface; other site
688269005026	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
688269005027	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688269005028	Walker A/P-loop; other site
688269005029	ATP binding site [chemical binding]; other site
688269005030	Q-loop/lid; other site
688269005031	ABC transporter signature motif; other site
688269005032	Walker B; other site
688269005033	D-loop; other site
688269005034	H-loop/switch region; other site
688269005035	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688269005036	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
688269005037	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688269005038	Walker A/P-loop; other site
688269005039	ATP binding site [chemical binding]; other site
688269005040	Q-loop/lid; other site
688269005041	ABC transporter signature motif; other site
688269005042	Walker B; other site
688269005043	D-loop; other site
688269005044	H-loop/switch region; other site
688269005045	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
688269005046	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
688269005047	Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915
688269005048	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
688269005049	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
688269005050	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
688269005051	active site
688269005052	catalytic residues [active]
688269005053	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
688269005054	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
688269005055	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688269005056	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
688269005057	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
688269005058	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
688269005059	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
688269005060	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
688269005061	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
688269005062	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
688269005063	Transcriptional regulators [Transcription]; Region: MarR; COG1846
688269005064	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269005065	PEGA domain; Region: PEGA; pfam08308
688269005066	PEGA domain; Region: PEGA; pfam08308
688269005067	S-layer homology domain; Region: SLH; pfam00395
688269005068	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
688269005069	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
688269005070	seryl-tRNA synthetase; Provisional; Region: PRK05431
688269005071	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
688269005072	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
688269005073	dimer interface [polypeptide binding]; other site
688269005074	active site
688269005075	motif 1; other site
688269005076	motif 2; other site
688269005077	motif 3; other site
688269005078	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
688269005079	Major Facilitator Superfamily; Region: MFS_1; pfam07690
688269005080	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688269005081	putative substrate translocation pore; other site
688269005082	GMP synthase; Reviewed; Region: guaA; PRK00074
688269005083	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
688269005084	AMP/PPi binding site [chemical binding]; other site
688269005085	candidate oxyanion hole; other site
688269005086	catalytic triad [active]
688269005087	potential glutamine specificity residues [chemical binding]; other site
688269005088	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
688269005089	ATP Binding subdomain [chemical binding]; other site
688269005090	Ligand Binding sites [chemical binding]; other site
688269005091	Dimerization subdomain; other site
688269005092	EamA-like transporter family; Region: EamA; cl01037
688269005093	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
688269005094	EamA-like transporter family; Region: EamA; cl01037
688269005095	Protein of unknown function (DUF342); Region: DUF342; pfam03961
688269005096	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
688269005097	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
688269005098	substrate binding pocket [chemical binding]; other site
688269005099	membrane-bound complex binding site; other site
688269005100	hinge residues; other site
688269005101	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
688269005102	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
688269005103	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688269005104	Zn2+ binding site [ion binding]; other site
688269005105	Mg2+ binding site [ion binding]; other site
688269005106	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
688269005107	RNA/DNA hybrid binding site [nucleotide binding]; other site
688269005108	active site
688269005109	glutamine synthetase, type I; Region: GlnA; TIGR00653
688269005110	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
688269005111	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
688269005112	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
688269005113	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
688269005114	ring oligomerisation interface [polypeptide binding]; other site
688269005115	ATP/Mg binding site [chemical binding]; other site
688269005116	stacking interactions; other site
688269005117	hinge regions; other site
688269005118	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320
688269005119	oligomerisation interface [polypeptide binding]; other site
688269005120	mobile loop; other site
688269005121	roof hairpin; other site
688269005122	cobyric acid synthase; Provisional; Region: PRK00784
688269005123	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
688269005124	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
688269005125	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
688269005126	catalytic triad [active]
688269005127	CobD/Cbib protein; Region: CobD_Cbib; cl00561
688269005128	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
688269005129	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688269005130	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269005131	homodimer interface [polypeptide binding]; other site
688269005132	catalytic residue [active]
688269005133	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561
688269005134	homodimer interface [polypeptide binding]; other site
688269005135	Walker A motif; other site
688269005136	ATP binding site [chemical binding]; other site
688269005137	hydroxycobalamin binding site [chemical binding]; other site
688269005138	Walker B motif; other site
688269005139	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This...; Region: Alpha_ANH_like_IV; cd01994
688269005140	Ligand Binding Site [chemical binding]; other site
688269005141	MJ0570-related uncharacterized domain; Region: MJ0570_dom; TIGR00290
688269005142	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
688269005143	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
688269005144	putative dimer interface [polypeptide binding]; other site
688269005145	active site pocket [active]
688269005146	putative cataytic base [active]
688269005147	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544
688269005148	homotrimer interface [polypeptide binding]; other site
688269005149	Walker A motif; other site
688269005150	GTP binding site [chemical binding]; other site
688269005151	Walker B motif; other site
688269005152	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
688269005153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
688269005154	Major Facilitator Superfamily; Region: MFS_1; pfam07690
688269005155	putative substrate translocation pore; other site
688269005156	Uncharacterized conserved protein [Function unknown]; Region: COG1284
688269005157	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
688269005158	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
688269005159	Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219
688269005160	rod shape-determining protein MreB; Provisional; Region: PRK13930
688269005161	Cell division protein FtsA; Region: FtsA; cl11496
688269005162	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
688269005163	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
688269005164	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
688269005165	substrate binding pocket [chemical binding]; other site
688269005166	chain length determination region; other site
688269005167	substrate-Mg2+ binding site; other site
688269005168	catalytic residues [active]
688269005169	aspartate-rich region 1; other site
688269005170	active site lid residues [active]
688269005171	aspartate-rich region 2; other site
688269005172	Uncharacterised ACR, COG1259; Region: DUF151; cl00553
688269005173	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
688269005174	putative acyl-acceptor binding pocket; other site
688269005175	hypothetical protein; Provisional; Region: PRK08328
688269005176	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757
688269005177	ATP binding site [chemical binding]; other site
688269005178	substrate interface [chemical binding]; other site
688269005179	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
688269005180	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192
688269005181	substrate binding site [chemical binding]; other site
688269005182	ATP binding site [chemical binding]; other site
688269005183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
688269005184	active site
688269005185	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
688269005186	phosphorylation site [posttranslational modification]
688269005187	intermolecular recognition site; other site
688269005188	dimerization interface [polypeptide binding]; other site
688269005189	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
688269005190	metal binding site [ion binding]; metal-binding site
688269005191	active site
688269005192	I-site; other site
688269005193	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
688269005194	gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
688269005195	N- and C-terminal domain interface [polypeptide binding]; other site
688269005196	putative active site [active]
688269005197	catalytic site [active]
688269005198	metal binding site [ion binding]; metal-binding site
688269005199	carbohydrate binding site [chemical binding]; other site
688269005200	ATP binding site [chemical binding]; other site
688269005201	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
688269005202	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269005203	Cupin domain; Region: Cupin_2; cl09118
688269005204	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
688269005205	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
688269005206	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
688269005207	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
688269005208	Walker A/P-loop; other site
688269005209	ATP binding site [chemical binding]; other site
688269005210	Q-loop/lid; other site
688269005211	ABC transporter signature motif; other site
688269005212	Walker B; other site
688269005213	D-loop; other site
688269005214	H-loop/switch region; other site
688269005215	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
688269005216	Transcriptional regulators [Transcription]; Region: FadR; COG2186
688269005217	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688269005218	DNA-binding site [nucleotide binding]; DNA binding site
688269005219	FCD domain; Region: FCD; cl11656
688269005220	alpha-glucosidase; Provisional; Region: PRK10426
688269005221	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
688269005222	putative active site [active]
688269005223	putative catalytic site [active]
688269005224	Strabismus protein; Region: Strabismus; pfam06638
688269005225	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
688269005226	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cl00947
688269005227	hexamer (dimer of trimers) interface [polypeptide binding]; other site
688269005228	substrate binding site [chemical binding]; other site
688269005229	trimer interface [polypeptide binding]; other site
688269005230	Mn binding site [ion binding]; other site
688269005231	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
688269005232	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
688269005233	NAD(P) binding site [chemical binding]; other site
688269005234	catalytic residues [active]
688269005235	SAF domain; Region: SAF; cl00555
688269005236	SAF domain; Region: SAF; cl00555
688269005237	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
688269005238	catalytic residue [active]
688269005239	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
688269005240	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269005241	putative PBP binding loops; other site
688269005242	dimer interface [polypeptide binding]; other site
688269005243	ABC-ATPase subunit interface; other site
688269005244	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688269005245	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269005246	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
688269005247	putative transporter; Provisional; Region: PRK11462
688269005248	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
688269005249	GIY-YIG motif/motif A; other site
688269005250	putative active site [active]
688269005251	putative metal binding site [ion binding]; other site
688269005252	D-alanyl-alanine synthetase A; Provisional; Region: PRK14571
688269005253	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
688269005254	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
688269005255	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
688269005256	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269005257	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
688269005258	Walker A motif; other site
688269005259	ATP binding site [chemical binding]; other site
688269005260	Walker B motif; other site
688269005261	arginine finger; other site
688269005262	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14469
688269005263	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269005264	FeS/SAM binding site; other site
688269005265	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
688269005266	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
688269005267	GTPase RsgA; Reviewed; Region: PRK00098
688269005268	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854
688269005269	GTPase/OB domain interface [polypeptide binding]; other site
688269005270	GTPase/Zn-binding domain interface [polypeptide binding]; other site
688269005271	GTP/Mg2+ binding site [chemical binding]; other site
688269005272	G4 box; other site
688269005273	G5 box; other site
688269005274	G1 box; other site
688269005275	Switch I region; other site
688269005276	G2 box; other site
688269005277	G3 box; other site
688269005278	Switch II region; other site
688269005279	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
688269005280	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
688269005281	substrate binding site [chemical binding]; other site
688269005282	hexamer interface [polypeptide binding]; other site
688269005283	metal binding site [ion binding]; metal-binding site
688269005284	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515
688269005285	active site
688269005286	dimerization interface [polypeptide binding]; other site
688269005287	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
688269005288	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
688269005289	HIGH motif; other site
688269005290	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
688269005291	active site
688269005292	KMSKS motif; other site
688269005293	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
688269005294	tRNA binding surface [nucleotide binding]; other site
688269005295	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
688269005296	hinge region; other site
688269005297	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
688269005298	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
688269005299	catalytic residue [active]
688269005300	putative FPP diphosphate  binding site; other site
688269005301	putative FPP binding hydrophobic cleft; other site
688269005302	dimer interface [polypeptide binding]; other site
688269005303	putative IPP diphosphate binding site; other site
688269005304	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
688269005305	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
688269005306	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673
688269005307	motif 1; other site
688269005308	active site
688269005309	motif 2; other site
688269005310	motif 3; other site
688269005311	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
688269005312	DHHA1 domain; Region: DHHA1; pfam02272
688269005313	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
688269005314	substrate binding site [chemical binding]; other site
688269005315	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
688269005316	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
688269005317	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269005318	dimer interface [polypeptide binding]; other site
688269005319	conserved gate region; other site
688269005320	putative PBP binding loops; other site
688269005321	ABC-ATPase subunit interface; other site
688269005322	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269005323	dimer interface [polypeptide binding]; other site
688269005324	conserved gate region; other site
688269005325	putative PBP binding loops; other site
688269005326	ABC-ATPase subunit interface; other site
688269005327	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
688269005328	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688269005329	Walker A/P-loop; other site
688269005330	ATP binding site [chemical binding]; other site
688269005331	Q-loop/lid; other site
688269005332	ABC transporter signature motif; other site
688269005333	Walker B; other site
688269005334	D-loop; other site
688269005335	H-loop/switch region; other site
688269005336	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688269005337	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
688269005338	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688269005339	Walker A/P-loop; other site
688269005340	ATP binding site [chemical binding]; other site
688269005341	Q-loop/lid; other site
688269005342	ABC transporter signature motif; other site
688269005343	Walker B; other site
688269005344	D-loop; other site
688269005345	H-loop/switch region; other site
688269005346	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688269005347	exopolyphosphatase; Region: exo_poly_only; TIGR03706
688269005348	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
688269005349	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
688269005350	Flagellar hook capping protein; Region: FlgD; cl04347
688269005351	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
688269005352	flagellar hook protein FlgE; Validated; Region: flgE; PRK08425
688269005353	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
688269005354	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
688269005355	Flagellar protein (FlbD); Region: FlbD; cl00683
688269005356	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
688269005357	flagellar motor protein MotP; Reviewed; Region: PRK06926
688269005358	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
688269005359	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
688269005360	ligand binding site [chemical binding]; other site
688269005361	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
688269005362	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
688269005363	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
688269005364	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
688269005365	flagellar motor switch protein FliY; Validated; Region: PRK08432
688269005366	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
688269005367	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
688269005368	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156
688269005369	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
688269005370	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
688269005371	dimerization interface [polypeptide binding]; other site
688269005372	putative Zn2+ binding site [ion binding]; other site
688269005373	putative DNA binding site [nucleotide binding]; other site
688269005374	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
688269005375	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
688269005376	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
688269005377	Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose...; Region: GT1_Trehalose_phosphorylase; cd03792
688269005378	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
688269005379	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269005380	dimer interface [polypeptide binding]; other site
688269005381	conserved gate region; other site
688269005382	putative PBP binding loops; other site
688269005383	ABC-ATPase subunit interface; other site
688269005384	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
688269005385	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269005386	putative PBP binding loops; other site
688269005387	ABC-ATPase subunit interface; other site
688269005388	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
688269005389	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
688269005390	chaperone protein DnaJ; Provisional; Region: PRK14282
688269005391	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
688269005392	HSP70 interaction site [polypeptide binding]; other site
688269005393	DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908
688269005394	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
688269005395	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446
688269005396	dimer interface [polypeptide binding]; other site
688269005397	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
688269005398	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
688269005399	HrcA protein C terminal domain; Region: HrcA; pfam01628
688269005400	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
688269005401	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
688269005402	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
688269005403	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
688269005404	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
688269005405	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
688269005406	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
688269005407	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
688269005408	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
688269005409	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852
688269005410	Mg++ binding site [ion binding]; other site
688269005411	putative catalytic motif [active]
688269005412	putative substrate binding site [chemical binding]; other site
688269005413	Phosphopantetheine attachment site; Region: PP-binding; cl09936
688269005414	Protein of unknown function DUF72; Region: DUF72; cl00777
688269005415	AP endonuclease family 2; Region: AP2Ec; smart00518
688269005416	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019
688269005417	AP (apurinic/apyrimidinic) site pocket; other site
688269005418	DNA interaction; other site
688269005419	Metal-binding active site; metal-binding site
688269005420	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
688269005421	Domain of unknown function (DUF814); Region: DUF814; pfam05670
688269005422	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
688269005423	Uncharacterized conserved protein [Function unknown]; Region: COG1543
688269005424	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
688269005425	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
688269005426	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
688269005427	2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179
688269005428	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
688269005429	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
688269005430	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
688269005431	dimer interface [polypeptide binding]; other site
688269005432	PYR/PP interface [polypeptide binding]; other site
688269005433	TPP binding site [chemical binding]; other site
688269005434	substrate binding site [chemical binding]; other site
688269005435	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
688269005436	TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea and some hyperthermophilic bacteria. PFOR catalyzes the...; Region: TPP_PFOR_porB_like; cd03376
688269005437	TPP-binding site [chemical binding]; other site
688269005438	putative dimer interface [polypeptide binding]; other site
688269005439	Isochorismatase family; Region: Isochorismatase; pfam00857
688269005440	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
688269005441	catalytic triad [active]
688269005442	conserved cis-peptide bond; other site
688269005443	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
688269005444	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl12019
688269005445	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl12019
688269005446	active site
688269005447	pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180
688269005448	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
688269005449	active site
688269005450	multimer interface [polypeptide binding]; other site
688269005451	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
688269005452	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
688269005453	predicted active site [active]
688269005454	catalytic triad [active]
688269005455	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
688269005456	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
688269005457	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269005458	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
688269005459	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-...; Region: AGAT_like; cd06451
688269005460	homodimer interface [polypeptide binding]; other site
688269005461	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269005462	catalytic residue [active]
688269005463	aspartate aminotransferase; Provisional; Region: PRK08361
688269005464	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
688269005465	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269005466	homodimer interface [polypeptide binding]; other site
688269005467	catalytic residue [active]
688269005468	Acetokinase family; Region: Acetate_kinase; cl01029
688269005469	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
688269005470	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
688269005471	Acetokinase family; Region: Acetate_kinase; cl01029
688269005472	hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512
688269005473	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
688269005474	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
688269005475	dimer interface [polypeptide binding]; other site
688269005476	PYR/PP interface [polypeptide binding]; other site
688269005477	TPP binding site [chemical binding]; other site
688269005478	substrate binding site [chemical binding]; other site
688269005479	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
688269005480	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
688269005481	TPP-binding site [chemical binding]; other site
688269005482	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
688269005483	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
688269005484	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
688269005485	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269005486	NAD(P) binding site [chemical binding]; other site
688269005487	active site
688269005488	translation initiation factor IF-2 subunit beta; Provisional; Region: PRK12336
688269005489	Protein of unknown function (DUF1175); Region: DUF1175; cl14898
688269005490	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
688269005491	MG2 domain; Region: A2M_N; pfam01835
688269005492	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
688269005493	Alpha-2-macroglobulin family; Region: A2M; pfam00207
688269005494	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
688269005495	surface patch; other site
688269005496	thioester region; other site
688269005497	specificity defining residues; other site
688269005498	protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13943
688269005499	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688269005500	S-adenosylmethionine binding site [chemical binding]; other site
688269005501	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
688269005502	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
688269005503	active site
688269005504	catalytic tetrad [active]
688269005505	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688269005506	Zn2+ binding site [ion binding]; other site
688269005507	Mg2+ binding site [ion binding]; other site
688269005508	The YihA (EngB) subfamily.  This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control.  YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876
688269005509	G1 box; other site
688269005510	GTP/Mg2+ binding site [chemical binding]; other site
688269005511	Switch I region; other site
688269005512	G2 box; other site
688269005513	G3 box; other site
688269005514	Switch II region; other site
688269005515	G4 box; other site
688269005516	G5 box; other site
688269005517	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
688269005518	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269005519	Walker A motif; other site
688269005520	ATP binding site [chemical binding]; other site
688269005521	Walker B motif; other site
688269005522	arginine finger; other site
688269005523	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
688269005524	Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520
688269005525	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
688269005526	active site
688269005527	dimerization interface [polypeptide binding]; other site
688269005528	Cupin domain; Region: Cupin_2; cl09118
688269005529	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
688269005530	active site
688269005531	metal binding site [ion binding]; metal-binding site
688269005532	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
688269005533	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
688269005534	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
688269005535	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
688269005536	active site
688269005537	HIGH motif; other site
688269005538	KMSK motif region; other site
688269005539	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
688269005540	tRNA binding surface [nucleotide binding]; other site
688269005541	anticodon binding site; other site
688269005542	adenylosuccinate lyase; Provisional; Region: PRK07492
688269005543	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
688269005544	tetramer interface [polypeptide binding]; other site
688269005545	active site
688269005546	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
688269005547	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
688269005548	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108
688269005549	GDP-binding site [chemical binding]; other site
688269005550	ACT binding site; other site
688269005551	IMP binding site; other site
688269005552	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
688269005553	FMN binding site [chemical binding]; other site
688269005554	dimer interface [polypeptide binding]; other site
688269005555	ornithine carbamoyltransferase; Validated; Region: PRK02102
688269005556	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
688269005557	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269005558	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
688269005559	DNA-binding site [nucleotide binding]; DNA binding site
688269005560	RNA-binding motif; other site
688269005561	Preprotein translocase SecG subunit; Region: SecG; cl09123
688269005562	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
688269005563	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
688269005564	active site
688269005565	HIGH motif; other site
688269005566	dimer interface [polypeptide binding]; other site
688269005567	KMSKS motif; other site
688269005568	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
688269005569	S-layer homology domain; Region: SLH; pfam00395
688269005570	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
688269005571	LemA family; Region: LemA; cl00742
688269005572	Peptidase family M48; Region: Peptidase_M48; cl12018
688269005573	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
688269005574	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269005575	Walker A motif; other site
688269005576	ATP binding site [chemical binding]; other site
688269005577	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269005578	Walker B motif; other site
688269005579	Divergent PAP2 family; Region: DUF212; cl00855
688269005580	GTP-binding protein YchF; Reviewed; Region: PRK09601
688269005581	YchF subfamily.  YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1.  Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900
688269005582	G1 box; other site
688269005583	GTP/Mg2+ binding site [chemical binding]; other site
688269005584	Switch I region; other site
688269005585	G2 box; other site
688269005586	Switch II region; other site
688269005587	G3 box; other site
688269005588	G4 box; other site
688269005589	G5 box; other site
688269005590	GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information on the function of the TGS domain, but...; Region: TGS; cl03735
688269005591	Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-...; Region: Macro_Af1521_BAL_like; cd02907
688269005592	ADP-ribose binding site [chemical binding]; other site
688269005593	OsmC-like protein; Region: OsmC; cl00767
688269005594	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
688269005595	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
688269005596	catalytic core [active]
688269005597	pyruvate kinase; Provisional; Region: PRK05826
688269005598	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
688269005599	domain interfaces; other site
688269005600	active site
688269005601	6-phosphofructokinase; Provisional; Region: PRK03202
688269005602	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204
688269005603	active site
688269005604	ADP/pyrophosphate binding site [chemical binding]; other site
688269005605	dimerization interface [polypeptide binding]; other site
688269005606	allosteric effector site; other site
688269005607	fructose-1,6-bisphosphate binding site; other site
688269005608	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
688269005609	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
688269005610	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848
688269005611	lipoyl attachment site [posttranslational modification]; other site
688269005612	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
688269005613	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613
688269005614	tetramer interface [polypeptide binding]; other site
688269005615	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269005616	catalytic residue [active]
688269005617	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
688269005618	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613
688269005619	tetramer interface [polypeptide binding]; other site
688269005620	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269005621	catalytic residue [active]
688269005622	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
688269005623	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
688269005624	motif II; other site
688269005625	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl01869
688269005626	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204
688269005627	6-phosphofructokinase; Provisional; Region: PRK03202
688269005628	active site
688269005629	ADP/pyrophosphate binding site [chemical binding]; other site
688269005630	dimerization interface [polypeptide binding]; other site
688269005631	allosteric effector site; other site
688269005632	fructose-1,6-bisphosphate binding site; other site
688269005633	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503
688269005634	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
688269005635	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350
688269005636	active site
688269005637	trimer interface [polypeptide binding]; other site
688269005638	substrate binding site [chemical binding]; other site
688269005639	CoA binding site [chemical binding]; other site
688269005640	acetylornithine aminotransferase; Provisional; Region: PRK02627
688269005641	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
688269005642	inhibitor-cofactor binding pocket; inhibition site
688269005643	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269005644	catalytic residue [active]
688269005645	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
688269005646	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
688269005647	metal binding site [ion binding]; metal-binding site
688269005648	dimer interface [polypeptide binding]; other site
688269005649	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
688269005650	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
688269005651	6-phosphofructokinase; Provisional; Region: PRK03202
688269005652	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204
688269005653	active site
688269005654	ADP/pyrophosphate binding site [chemical binding]; other site
688269005655	dimerization interface [polypeptide binding]; other site
688269005656	allosteric effector site; other site
688269005657	fructose-1,6-bisphosphate binding site; other site
688269005658	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
688269005659	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
688269005660	ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879
688269005661	L-serine binding site [chemical binding]; other site
688269005662	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
688269005663	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
688269005664	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
688269005665	Transthyretin-like family; Region: DUF290; pfam01060
688269005666	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which...; Region: SERPIN; cd00172
688269005667	reactive center loop; other site
688269005668	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
688269005669	EamA-like transporter family; Region: EamA; cl01037
688269005670	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
688269005671	Protein of unknown function (DUF1576); Region: DUF1576; pfam07613
688269005672	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
688269005673	metal-binding site [ion binding]
688269005674	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
688269005675	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
688269005676	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
688269005677	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269005678	Walker A/P-loop; other site
688269005679	ATP binding site [chemical binding]; other site
688269005680	Q-loop/lid; other site
688269005681	ABC transporter signature motif; other site
688269005682	Walker B; other site
688269005683	D-loop; other site
688269005684	H-loop/switch region; other site
688269005685	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
688269005686	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
688269005687	TM-ABC transporter signature motif; other site
688269005688	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
688269005689	TM-ABC transporter signature motif; other site
688269005690	dihydroorotase, multifunctional complex type; Region: pyrC_multi; TIGR00857
688269005691	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
688269005692	active site
688269005693	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
688269005694	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868
688269005695	FAD binding pocket [chemical binding]; other site
688269005696	conserved FAD binding motif [chemical binding]; other site
688269005697	phosphate binding motif [ion binding]; other site
688269005698	beta-alpha-beta structure motif; other site
688269005699	NAD binding pocket [chemical binding]; other site
688269005700	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
688269005701	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
688269005702	phosphate binding site [ion binding]; other site
688269005703	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
688269005704	active site
688269005705	dimer interface [polypeptide binding]; other site
688269005706	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
688269005707	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
688269005708	diiron binding motif [ion binding]; other site
688269005709	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
688269005710	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023
688269005711	Sugar specificity; other site
688269005712	Pyrimidine base specificity; other site
688269005713	ATP-binding site [chemical binding]; other site
688269005714	glycogen synthase; Provisional; Region: glgA; PRK00654
688269005715	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
688269005716	ADP-binding pocket [chemical binding]; other site
688269005717	homodimer interface [polypeptide binding]; other site
688269005718	ADP-glucose phosphorylase; Region: PLN02643
688269005719	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
688269005720	dimer interface [polypeptide binding]; other site
688269005721	active site
688269005722	Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005
688269005723	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353
688269005724	16S/18S rRNA binding site [nucleotide binding]; other site
688269005725	S13e-L30e interaction site [polypeptide binding]; other site
688269005726	25S rRNA binding site [nucleotide binding]; other site
688269005727	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
688269005728	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
688269005729	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
688269005730	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
688269005731	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
688269005732	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
688269005733	putative nucleic acid binding region [nucleotide binding]; other site
688269005734	G-X-X-G motif; other site
688269005735	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
688269005736	RNA binding site [nucleotide binding]; other site
688269005737	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
688269005738	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
688269005739	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
688269005740	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688269005741	Zn2+ binding site [ion binding]; other site
688269005742	Mg2+ binding site [ion binding]; other site
688269005743	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
688269005744	dinuclear metal binding motif [ion binding]; other site
688269005745	GatB domain; Region: GatB_Yqey; cl11497
688269005746	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
688269005747	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
688269005748	TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes.  It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes.  TrmE contains a GTPase...; Region: trmE; cd04164
688269005749	G1 box; other site
688269005750	GTP/Mg2+ binding site [chemical binding]; other site
688269005751	Switch I region; other site
688269005752	G2 box; other site
688269005753	Switch II region; other site
688269005754	G3 box; other site
688269005755	G4 box; other site
688269005756	G5 box; other site
688269005757	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
688269005758	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
688269005759	IHF dimer interface [polypeptide binding]; other site
688269005760	IHF - DNA interface [nucleotide binding]; other site
688269005761	pyruvate phosphate dikinase; Provisional; Region: PRK09279
688269005762	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
688269005763	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
688269005764	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
688269005765	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
688269005766	S-adenosylmethionine binding site [chemical binding]; other site
688269005767	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
688269005768	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
688269005769	Walker A/P-loop; other site
688269005770	ATP binding site [chemical binding]; other site
688269005771	Q-loop/lid; other site
688269005772	ABC transporter signature motif; other site
688269005773	Walker B; other site
688269005774	D-loop; other site
688269005775	H-loop/switch region; other site
688269005776	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
688269005777	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
688269005778	Walker A/P-loop; other site
688269005779	ATP binding site [chemical binding]; other site
688269005780	Q-loop/lid; other site
688269005781	ABC transporter signature motif; other site
688269005782	Walker B; other site
688269005783	D-loop; other site
688269005784	H-loop/switch region; other site
688269005785	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
688269005786	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
688269005787	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
688269005788	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
688269005789	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
688269005790	23S rRNA binding site [nucleotide binding]; other site
688269005791	L21 binding site [polypeptide binding]; other site
688269005792	L13 binding site [polypeptide binding]; other site
688269005793	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984
688269005794	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
688269005795	zinc binding site [ion binding]; other site
688269005796	putative ligand binding site [chemical binding]; other site
688269005797	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
688269005798	TM-ABC transporter signature motif; other site
688269005799	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
688269005800	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
688269005801	Walker A/P-loop; other site
688269005802	ATP binding site [chemical binding]; other site
688269005803	Q-loop/lid; other site
688269005804	ABC transporter signature motif; other site
688269005805	Walker B; other site
688269005806	D-loop; other site
688269005807	H-loop/switch region; other site
688269005808	diaminopimelate decarboxylase; Region: lysA; TIGR01048
688269005809	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
688269005810	active site
688269005811	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
688269005812	substrate binding site [chemical binding]; other site
688269005813	catalytic residues [active]
688269005814	dimer interface [polypeptide binding]; other site
688269005815	Domain of unknown function (DUF74); Region: DUF74; cl00426
688269005816	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
688269005817	Predicted transcriptional regulators [Transcription]; Region: COG1725
688269005818	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
688269005819	DNA-binding site [nucleotide binding]; DNA binding site
688269005820	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
688269005821	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
688269005822	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
688269005823	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
688269005824	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
688269005825	Ligand Binding Site [chemical binding]; other site
688269005826	B3/4 domain; Region: B3_4; cl11458
688269005827	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
688269005828	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
688269005829	Walker A motif; other site
688269005830	ATP binding site [chemical binding]; other site
688269005831	Walker B motif; other site
688269005832	arginine finger; other site
688269005833	Peptidase family M41; Region: Peptidase_M41; pfam01434
688269005834	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
688269005835	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
688269005836	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
688269005837	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
688269005838	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
688269005839	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
688269005840	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
688269005841	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
688269005842	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
688269005843	DNA binding residues [nucleotide binding]
688269005844	DNA primase; Validated; Region: dnaG; PRK05667
688269005845	CHC2 zinc finger; Region: zf-CHC2; cl02597
688269005846	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
688269005847	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
688269005848	active site
688269005849	metal binding site [ion binding]; metal-binding site
688269005850	interdomain interaction site; other site
688269005851	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
688269005852	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
688269005853	23S rRNA interface [nucleotide binding]; other site
688269005854	L3 interface [polypeptide binding]; other site
688269005855	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
688269005856	Protein of unknown function (DUF464); Region: DUF464; cl01080
688269005857	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
688269005858	Protein of unknown function(DUF2089); Region: DUF2089; pfam09862
688269005859	Terminase small subunit; Region: Terminase_2; cl01513
688269005860	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
688269005861	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
688269005862	active site
688269005863	HIGH motif; other site
688269005864	nucleotide binding site [chemical binding]; other site
688269005865	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
688269005866	active site
688269005867	KMSKS motif; other site
688269005868	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
688269005869	tRNA binding surface [nucleotide binding]; other site
688269005870	anticodon binding site; other site
688269005871	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
688269005872	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
688269005873	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
688269005874	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
688269005875	RuvA N terminal domain; Region: RuvA_N; pfam01330
688269005876	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
688269005877	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
688269005878	Zn2+ binding site [ion binding]; other site
688269005879	Mg2+ binding site [ion binding]; other site
688269005880	GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information on the function of the TGS domain, but...; Region: TGS; cl03735
688269005881	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
688269005882	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
688269005883	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
688269005884	active site
688269005885	dimer interface [polypeptide binding]; other site
688269005886	motif 1; other site
688269005887	motif 2; other site
688269005888	motif 3; other site
688269005889	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
688269005890	anticodon binding site; other site
688269005891	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
688269005892	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
688269005893	active site
688269005894	dimer interface [polypeptide binding]; other site
688269005895	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
688269005896	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
688269005897	Walker A/P-loop; other site
688269005898	ATP binding site [chemical binding]; other site
688269005899	Q-loop/lid; other site
688269005900	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
688269005901	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
688269005902	ABC transporter signature motif; other site
688269005903	Walker B; other site
688269005904	D-loop; other site
688269005905	H-loop/switch region; other site
688269005906	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424
688269005907	dimer interface [polypeptide binding]; other site
688269005908	ADP-ribose binding site [chemical binding]; other site
688269005909	active site
688269005910	nudix motif; other site
688269005911	metal binding site [ion binding]; metal-binding site
688269005912	Flagellar protein FliS; Region: FliS; cl00654
688269005913	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
688269005914	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
688269005915	Coenzyme A binding pocket [chemical binding]; other site
688269005916	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
688269005917	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
688269005918	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
688269005919	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
688269005920	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293
688269005921	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269005922	FeS/SAM binding site; other site
688269005923	CAAX amino terminal protease self- immunity; Region: Abi; cl00558
688269005924	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
688269005925	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688269005926	Walker A/P-loop; other site
688269005927	ATP binding site [chemical binding]; other site
688269005928	Q-loop/lid; other site
688269005929	ABC transporter signature motif; other site
688269005930	Walker B; other site
688269005931	D-loop; other site
688269005932	H-loop/switch region; other site
688269005933	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688269005934	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
688269005935	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
688269005936	Walker A/P-loop; other site
688269005937	ATP binding site [chemical binding]; other site
688269005938	Q-loop/lid; other site
688269005939	ABC transporter signature motif; other site
688269005940	Walker B; other site
688269005941	D-loop; other site
688269005942	H-loop/switch region; other site
688269005943	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
688269005944	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
688269005945	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
688269005946	dimer interface [polypeptide binding]; other site
688269005947	conserved gate region; other site
688269005948	putative PBP binding loops; other site
688269005949	ABC-ATPase subunit interface; other site
688269005950	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
688269005951	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
688269005952	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
688269005953	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
688269005954	Threonine dehydrogenase; Region: TDH; cd05281
688269005955	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
688269005956	structural Zn binding site [ion binding]; other site
688269005957	catalytic Zn binding site [ion binding]; other site
688269005958	tetramer interface [polypeptide binding]; other site
688269005959	NADP binding site [chemical binding]; other site
688269005960	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
688269005961	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454
688269005962	substrate-cofactor binding pocket; other site
688269005963	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269005964	catalytic residue [active]
688269005965	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
688269005966	DAK2 domain; Region: Dak2; cl03685
688269005967	Protein of unknown function (DUF322); Region: DUF322; cl00574
688269005968	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
688269005969	TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007
688269005970	TPP-binding site; other site
688269005971	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
688269005972	PYR/PP interface [polypeptide binding]; other site
688269005973	dimer interface [polypeptide binding]; other site
688269005974	TPP binding site [chemical binding]; other site
688269005975	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
688269005976	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
688269005977	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
688269005978	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489
688269005979	generic binding surface II; other site
688269005980	generic binding surface I; other site
688269005981	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
688269005982	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
688269005983	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
688269005984	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
688269005985	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
688269005986	inhibitor-cofactor binding pocket; inhibition site
688269005987	pyridoxal 5'-phosphate binding site [chemical binding]; other site
688269005988	catalytic residue [active]
688269005989	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
688269005990	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
688269005991	Domain of unknown function (DUF369); Region: DUF369; cl00950
688269005992	NAD-dependent deacetylase; Provisional; Region: PRK14138
688269005993	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195
688269005994	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
688269005995	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174
688269005996	substrate binding site [chemical binding]; other site
688269005997	dimer interface [polypeptide binding]; other site
688269005998	ATP binding site [chemical binding]; other site
688269005999	CTP synthetase; Validated; Region: pyrG; PRK05380
688269006000	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113
688269006001	Catalytic site [active]
688269006002	Active site [active]
688269006003	UTP binding site [chemical binding]; other site
688269006004	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
688269006005	active site
688269006006	putative oxyanion hole; other site
688269006007	catalytic triad [active]
688269006008	Domain of unknown function (DUF3552); Region: DUF3552; pfam12072
688269006009	phosphodiesterase; Provisional; Region: PRK12704
688269006010	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
688269006011	RecX family; Region: RecX; cl00936
688269006012	protein RecA; Region: tigrfam_recA; TIGR02012
688269006013	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
688269006014	Walker A motif; other site
688269006015	ATP binding site [chemical binding]; other site
688269006016	Walker B motif; other site
688269006017	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
688269006018	2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834
688269006019	2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834
688269006020	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
688269006021	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
688269006022	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
688269006023	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
688269006024	FeS/SAM binding site; other site
688269006025	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
688269006026	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
688269006027	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673
688269006028	Substrate-binding site [chemical binding]; other site
688269006029	Substrate specificity [chemical binding]; other site
688269006030	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
688269006031	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673
688269006032	Substrate-binding site [chemical binding]; other site
688269006033	Substrate specificity [chemical binding]; other site
688269006034	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
688269006035	active site
688269006036	dimerization interface [polypeptide binding]; other site
688269006037	excinuclease ABC subunit B; Provisional; Region: PRK05298
688269006038	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
688269006039	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
688269006040	ATP-binding site [chemical binding]; other site
688269006041	ATP binding site [chemical binding]; other site
688269006042	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
688269006043	nucleotide binding region [chemical binding]; other site
688269006044	ATP-binding site [chemical binding]; other site
688269006045	Ultra-violet resistance protein B; Region: UvrB; pfam12344
688269006046	UvrB/uvrC motif; Region: UVR; pfam02151
688269006047	Family of unknown function (DUF500); Region: DUF500; cl01109
688269006048	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141