-- dump date 20111121_015420 -- class Genbank::misc_feature -- table misc_feature_note -- id note 396595000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 396595000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595000003 Walker A motif; other site 396595000004 ATP binding site [chemical binding]; other site 396595000005 Walker B motif; other site 396595000006 arginine finger; other site 396595000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 396595000008 DnaA box-binding interface [nucleotide binding]; other site 396595000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 396595000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 396595000011 putative DNA binding surface [nucleotide binding]; other site 396595000012 dimer interface [polypeptide binding]; other site 396595000013 beta-clamp/clamp loader binding surface; other site 396595000014 beta-clamp/translesion DNA polymerase binding surface; other site 396595000015 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595000016 recombination protein F; Reviewed; Region: recF; PRK00064 396595000017 Walker A/P-loop; other site 396595000018 ATP binding site [chemical binding]; other site 396595000019 Q-loop/lid; other site 396595000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595000021 ABC transporter signature motif; other site 396595000022 Walker B; other site 396595000023 D-loop; other site 396595000024 H-loop/switch region; other site 396595000025 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 396595000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 396595000027 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 396595000028 anchoring element; other site 396595000029 dimer interface [polypeptide binding]; other site 396595000030 ATP binding site [chemical binding]; other site 396595000031 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 396595000032 active site 396595000033 putative metal-binding site [ion binding]; other site 396595000034 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 396595000035 oligopeptidase A; Provisional; Region: PRK10911 396595000036 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 396595000037 active site 396595000038 Zn binding site [ion binding]; other site 396595000039 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 396595000040 putative phosphate binding site [ion binding]; other site 396595000041 putative catalytic site [active] 396595000042 active site 396595000043 metal binding site A [ion binding]; metal-binding site 396595000044 DNA binding site [nucleotide binding] 396595000045 putative AP binding site [nucleotide binding]; other site 396595000046 putative metal binding site B [ion binding]; other site 396595000047 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 396595000048 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 396595000049 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 396595000050 catalytic loop [active] 396595000051 iron binding site [ion binding]; other site 396595000052 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD...; Region: flavin_oxioreductase; cd06189 396595000053 FAD binding pocket [chemical binding]; other site 396595000054 FAD binding motif [chemical binding]; other site 396595000055 phosphate binding motif [ion binding]; other site 396595000056 beta-alpha-beta structure motif; other site 396595000057 NAD binding pocket [chemical binding]; other site 396595000058 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 396595000059 active site 396595000060 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 396595000061 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 396595000062 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 396595000063 domain interfaces; other site 396595000064 active site 396595000065 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 396595000066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595000067 active site 396595000068 phosphorylation site [posttranslational modification] 396595000069 intermolecular recognition site; other site 396595000070 dimerization interface [polypeptide binding]; other site 396595000071 LytTr DNA-binding domain; Region: LytTR; cl04498 396595000072 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 396595000073 Histidine kinase; Region: His_kinase; pfam06580 396595000074 argininosuccinate lyase; Provisional; Region: PRK00855 396595000075 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 396595000076 active sites [active] 396595000077 tetramer interface [polypeptide binding]; other site 396595000078 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 396595000079 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 396595000080 Ligand Binding Site [chemical binding]; other site 396595000081 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 396595000082 Sulfate transporter family; Region: Sulfate_transp; cl00967 396595000083 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 396595000084 Rhomboid family; Region: Rhomboid; cl11446 396595000085 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 396595000086 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 396595000087 N-terminal plug; other site 396595000088 ligand-binding site [chemical binding]; other site 396595000089 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 396595000090 eyelet of channel; other site 396595000091 trimer interface [polypeptide binding]; other site 396595000092 BCCT family transporter; Region: BCCT; cl00569 396595000093 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 396595000094 eyelet of channel; other site 396595000095 trimer interface [polypeptide binding]; other site 396595000096 Transcriptional regulators [Transcription]; Region: MarR; COG1846 396595000097 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595000098 allantoate amidohydrolase; Reviewed; Region: PRK09290 396595000099 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 396595000100 active site 396595000101 metal binding site [ion binding]; metal-binding site 396595000102 dimer interface [polypeptide binding]; other site 396595000103 Isochorismatase family; Region: Isochorismatase; pfam00857 396595000104 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 396595000105 catalytic triad [active] 396595000106 conserved cis-peptide bond; other site 396595000107 Sodium:solute symporter family; Region: SSF; cl00456 396595000108 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 396595000109 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 396595000110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595000111 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 396595000112 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 396595000113 active site 396595000114 dimer interface [polypeptide binding]; other site 396595000115 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 396595000116 Ligand Binding Site [chemical binding]; other site 396595000117 Molecular Tunnel; other site 396595000118 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 396595000119 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 396595000120 putative substrate binding site [chemical binding]; other site 396595000121 putative ATP binding site [chemical binding]; other site 396595000122 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595000123 metal binding site [ion binding]; metal-binding site 396595000124 active site 396595000125 I-site; other site 396595000126 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 396595000127 putative catalytic site [active] 396595000128 putative phosphate binding site [ion binding]; other site 396595000129 putative metal binding site [ion binding]; other site 396595000130 acetolactate synthase; Reviewed; Region: PRK08322 396595000131 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 396595000132 PYR/PP interface [polypeptide binding]; other site 396595000133 dimer interface [polypeptide binding]; other site 396595000134 TPP binding site [chemical binding]; other site 396595000135 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 396595000136 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 396595000137 TPP-binding site [chemical binding]; other site 396595000138 dimer interface [polypeptide binding]; other site 396595000139 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 396595000140 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 396595000141 catalytic residues [active] 396595000142 hinge region; other site 396595000143 alpha helical domain; other site 396595000144 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 396595000145 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 396595000146 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 396595000147 Cytochrome c; Region: Cytochrom_C; cl11414 396595000148 Cytochrome c; Region: Cytochrom_C; cl11414 396595000149 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 396595000150 G1 box; other site 396595000151 GTP/Mg2+ binding site [chemical binding]; other site 396595000152 Switch I region; other site 396595000153 G2 box; other site 396595000154 G3 box; other site 396595000155 Switch II region; other site 396595000156 G4 box; other site 396595000157 G5 box; other site 396595000158 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 396595000159 Cu(I) binding site [ion binding]; other site 396595000160 DNA polymerase I; Provisional; Region: PRK05755 396595000161 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 396595000162 active site 396595000163 metal binding site 1 [ion binding]; metal-binding site 396595000164 putative 5' ssDNA interaction site; other site 396595000165 metal binding site 3; metal-binding site 396595000166 metal binding site 2 [ion binding]; metal-binding site 396595000167 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 396595000168 putative DNA binding site [nucleotide binding]; other site 396595000169 putative metal binding site [ion binding]; other site 396595000170 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 396595000171 active site 396595000172 catalytic site [active] 396595000173 substrate binding site [chemical binding]; other site 396595000174 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 396595000175 active site 396595000176 DNA binding site [nucleotide binding] 396595000177 catalytic site [active] 396595000178 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 396595000179 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 396595000180 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 396595000181 active site 396595000182 ATP binding site [chemical binding]; other site 396595000183 substrate binding site [chemical binding]; other site 396595000184 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 396595000185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 396595000186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595000187 ATP binding site [chemical binding]; other site 396595000188 Mg2+ binding site [ion binding]; other site 396595000189 G-X-G motif; other site 396595000190 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 396595000191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595000192 active site 396595000193 phosphorylation site [posttranslational modification] 396595000194 intermolecular recognition site; other site 396595000195 dimerization interface [polypeptide binding]; other site 396595000196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595000197 Walker A motif; other site 396595000198 ATP binding site [chemical binding]; other site 396595000199 Walker B motif; other site 396595000200 arginine finger; other site 396595000201 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 396595000202 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 396595000203 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 396595000204 heterodimer interface [polypeptide binding]; other site 396595000205 active site 396595000206 FMN binding site [chemical binding]; other site 396595000207 homodimer interface [polypeptide binding]; other site 396595000208 substrate binding site [chemical binding]; other site 396595000209 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 396595000210 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 396595000211 Chlorophyllase; Region: Chlorophyllase; cl15281 396595000212 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 396595000213 active site 396595000214 ADP/pyrophosphate binding site [chemical binding]; other site 396595000215 dimerization interface [polypeptide binding]; other site 396595000216 allosteric effector site; other site 396595000217 fructose-1,6-bisphosphate binding site; other site 396595000218 adenylate kinase; Reviewed; Region: adk; PRK00279 396595000219 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 396595000220 AMP-binding site [chemical binding]; other site 396595000221 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 396595000222 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl04869 396595000223 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 396595000224 4Fe-4S binding domain; Region: Fer4; cl02805 396595000225 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 396595000226 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 396595000227 molybdopterin cofactor binding site; other site 396595000228 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 396595000229 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD...; Region: MopB_CT_2; cd02783 396595000230 putative molybdopterin cofactor binding site; other site 396595000231 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 396595000232 active site 396595000233 metal binding site [ion binding]; metal-binding site 396595000234 homotetramer interface [polypeptide binding]; other site 396595000235 FOG: CBS domain [General function prediction only]; Region: COG0517 396595000236 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 396595000237 ATP-sulfurylase; Region: ATPS; cd00517 396595000238 active site 396595000239 HXXH motif; other site 396595000240 flexible loop; other site 396595000241 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 396595000242 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 396595000243 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 396595000244 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 396595000245 domain; Region: Succ_DH_flav_C; pfam02910 396595000246 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 396595000247 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 396595000248 muropeptide transporter; Reviewed; Region: ampG; PRK11902 396595000249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 396595000250 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 396595000251 putative active site [active] 396595000252 putative DNA binding site [nucleotide binding]; other site 396595000253 putative phosphate binding site [ion binding]; other site 396595000254 putative catalytic site [active] 396595000255 metal binding site A [ion binding]; metal-binding site 396595000256 putative AP binding site [nucleotide binding]; other site 396595000257 putative metal binding site B [ion binding]; other site 396595000258 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 396595000259 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 396595000260 putative peptidoglycan binding site; other site 396595000261 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 396595000262 Active site [active] 396595000263 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 396595000264 Transposase domain (DUF772); Region: DUF772; cl12084 396595000265 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 396595000266 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 396595000267 EamA-like transporter family; Region: EamA; cl01037 396595000268 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 396595000269 EamA-like transporter family; Region: EamA; cl01037 396595000270 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 396595000271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595000272 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 396595000273 Chromate transporter; Region: Chromate_transp; pfam02417 396595000274 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 396595000275 Chromate transporter; Region: Chromate_transp; pfam02417 396595000276 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 396595000277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 396595000278 Transposase; Region: DDE_Tnp_ISL3; pfam01610 396595000279 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-...; Region: FBPase; cd00354 396595000280 AMP binding site [chemical binding]; other site 396595000281 metal binding site [ion binding]; metal-binding site 396595000282 active site 396595000283 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 396595000284 active site 396595000285 ADP/pyrophosphate binding site [chemical binding]; other site 396595000286 allosteric effector site; other site 396595000287 dimerization interface [polypeptide binding]; other site 396595000288 fructose-1,6-bisphosphate binding site; other site 396595000289 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 396595000290 putative active site [active] 396595000291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595000292 binding surface 396595000293 TPR motif; other site 396595000294 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 396595000295 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 396595000296 active site 396595000297 (T/H)XGH motif; other site 396595000298 hypothetical protein; Provisional; Region: PRK13795 396595000299 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 396595000300 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 396595000301 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 396595000302 DsrE/DsrF-like family; Region: DrsE; cl00672 396595000303 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 396595000304 UvrD/REP helicase; Region: UvrD-helicase; cl14126 396595000305 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 396595000306 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 396595000307 TPP-binding site [chemical binding]; other site 396595000308 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 396595000309 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 396595000310 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 396595000311 E3 interaction surface; other site 396595000312 lipoyl attachment site [posttranslational modification]; other site 396595000313 e3 binding domain; Region: E3_binding; pfam02817 396595000314 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 396595000315 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 396595000316 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 396595000317 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 396595000318 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 396595000319 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595000320 metal binding site [ion binding]; metal-binding site 396595000321 active site 396595000322 I-site; other site 396595000323 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 396595000324 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 396595000325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 396595000326 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 396595000327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595000328 Protein of unknown function (DUF971); Region: DUF971; cl01414 396595000329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 396595000330 Integrase core domain; Region: rve; cl01316 396595000331 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 396595000332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595000333 Walker A motif; other site 396595000334 ATP binding site [chemical binding]; other site 396595000335 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595000336 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 396595000337 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 396595000338 active site 396595000339 HslU subunit interaction site [polypeptide binding]; other site 396595000340 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 396595000341 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 396595000342 DNA binding site [nucleotide binding] 396595000343 Int/Topo IB signature motif; other site 396595000344 active site 396595000345 Protein of unknown function, DUF484; Region: DUF484; cl01228 396595000346 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 396595000347 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 396595000348 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 396595000349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595000350 diaminopimelate decarboxylase; Region: lysA; TIGR01048 396595000351 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 396595000352 active site 396595000353 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 396595000354 substrate binding site [chemical binding]; other site 396595000355 catalytic residues [active] 396595000356 dimer interface [polypeptide binding]; other site 396595000357 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 396595000358 Predicted secreted protein [Function unknown]; Region: COG5501; cl02313 396595000359 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 396595000360 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 396595000361 putative active site pocket [active] 396595000362 4-fold oligomerization interface [polypeptide binding]; other site 396595000363 metal binding residues [ion binding]; metal-binding site 396595000364 3-fold/trimer interface [polypeptide binding]; other site 396595000365 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 396595000366 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 396595000367 putative active site [active] 396595000368 oxyanion strand; other site 396595000369 catalytic triad [active] 396595000370 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 396595000371 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 396595000372 catalytic residues [active] 396595000373 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 396595000374 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 396595000375 substrate binding site [chemical binding]; other site 396595000376 glutamase interaction surface [polypeptide binding]; other site 396595000377 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 396595000378 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 396595000379 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 396595000380 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 396595000381 Sulfatase; Region: Sulfatase; cl10460 396595000382 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 396595000383 Cupin domain; Region: Cupin_2; cl09118 396595000384 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 396595000385 Catalytic domain of Protein Kinases; Region: PKc; cd00180 396595000386 active site 396595000387 ATP binding site [chemical binding]; other site 396595000388 substrate binding site [chemical binding]; other site 396595000389 activation loop (A-loop); other site 396595000390 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 396595000391 phosphopeptide binding site; other site 396595000392 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595000393 metal binding site [ion binding]; metal-binding site 396595000394 active site 396595000395 I-site; other site 396595000396 ThiC family; Region: ThiC; cl08031 396595000397 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 396595000398 Phosphate transporter family; Region: PHO4; cl00396 396595000399 Phosphate transporter family; Region: PHO4; cl00396 396595000400 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 396595000401 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 396595000402 FeS/SAM binding site; other site 396595000403 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 396595000404 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 396595000405 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 396595000406 molybdopterin cofactor binding site; other site 396595000407 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 396595000408 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD...; Region: MopB_CT_2; cd02783 396595000409 putative molybdopterin cofactor binding site; other site 396595000410 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 396595000411 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl04869 396595000412 Cytochrome c; Region: Cytochrom_C; cl11414 396595000413 Cytochrome c; Region: Cytochrom_C; cl11414 396595000414 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 396595000415 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595000416 Membrane fusogenic activity; Region: BMFP; cl01115 396595000417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595000418 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 396595000419 NAD(P) binding site [chemical binding]; other site 396595000420 active site 396595000421 Uncharacterized conserved protein [Function unknown]; Region: COG1565 396595000422 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 396595000423 UGMP family protein; Validated; Region: PRK09604 396595000424 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 396595000425 Domain of unknown function (DUF205); Region: DUF205; cl00410 396595000426 putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738 396595000427 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 396595000428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595000429 S-adenosylmethionine binding site [chemical binding]; other site 396595000430 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the...; Region: cbb3_Oxidase_I; cd01661 396595000431 Low-spin heme binding site [chemical binding]; other site 396595000432 Putative water exit pathway; other site 396595000433 Binuclear center (active site) [active] 396595000434 Putative proton exit pathway; other site 396595000435 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 396595000436 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of...; Region: cbb3_Oxidase_CcoQ; cl00282 396595000437 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 396595000438 Cytochrome c; Region: Cytochrom_C; cl11414 396595000439 Cytochrome c; Region: Cytochrom_C; cl11414 396595000440 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 396595000441 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 396595000442 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 396595000443 FixH; Region: FixH; cl01254 396595000444 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 396595000445 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 396595000446 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 396595000447 metal-binding site [ion binding] 396595000448 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 396595000449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 396595000450 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 396595000451 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 396595000452 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 396595000453 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 396595000454 DNA binding residues [nucleotide binding] 396595000455 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 396595000456 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 396595000457 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595000458 Walker A/P-loop; other site 396595000459 ATP binding site [chemical binding]; other site 396595000460 Q-loop/lid; other site 396595000461 ABC transporter signature motif; other site 396595000462 Walker B; other site 396595000463 D-loop; other site 396595000464 H-loop/switch region; other site 396595000465 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 396595000466 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 396595000467 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 396595000468 P loop; other site 396595000469 GTP binding site [chemical binding]; other site 396595000470 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 396595000471 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 396595000472 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 396595000473 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 396595000474 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 396595000475 magnesium protoporphyrin O-methyltransferase; Region: BchM-ChlM; TIGR02021 396595000476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595000477 S-adenosylmethionine binding site [chemical binding]; other site 396595000478 BCCT family transporter; Region: BCCT; cl00569 396595000479 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 396595000480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595000481 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 396595000482 homodimer interface [polypeptide binding]; other site 396595000483 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 396595000484 active site pocket [active] 396595000485 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 396595000486 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 396595000487 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 396595000488 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 396595000489 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 396595000490 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 396595000491 purine monophosphate binding site [chemical binding]; other site 396595000492 dimer interface [polypeptide binding]; other site 396595000493 putative catalytic residues [active] 396595000494 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 396595000495 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 396595000496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595000497 S-adenosylmethionine binding site [chemical binding]; other site 396595000498 tocopherol O-methyltransferase; Region: PLN02244 396595000499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595000500 S-adenosylmethionine binding site [chemical binding]; other site 396595000501 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 396595000502 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 396595000503 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 396595000504 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 396595000505 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 396595000506 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 396595000507 substrate binding pocket [chemical binding]; other site 396595000508 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 396595000509 B12 binding site [chemical binding]; other site 396595000510 cobalt ligand [ion binding]; other site 396595000511 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 396595000512 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 396595000513 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 396595000514 feedback inhibition sensing region; other site 396595000515 homohexameric interface [polypeptide binding]; other site 396595000516 nucleotide binding site [chemical binding]; other site 396595000517 N-acetyl-L-glutamate binding site [chemical binding]; other site 396595000518 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 396595000519 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275 396595000520 Putative water exit pathway; other site 396595000521 Binuclear center (active site) [active] 396595000522 K-pathway; other site 396595000523 Putative proton exit pathway; other site 396595000524 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 396595000525 Cu(I) binding site [ion binding]; other site 396595000526 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 396595000527 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 396595000528 heme-binding site [chemical binding]; other site 396595000529 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 396595000530 FAD binding pocket [chemical binding]; other site 396595000531 FAD binding motif [chemical binding]; other site 396595000532 phosphate binding motif [ion binding]; other site 396595000533 beta-alpha-beta structure motif; other site 396595000534 NAD binding pocket [chemical binding]; other site 396595000535 Heme binding pocket [chemical binding]; other site 396595000536 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 396595000537 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 396595000538 catalytic triad [active] 396595000539 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 396595000540 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 396595000541 active site 396595000542 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 396595000543 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 396595000544 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 396595000545 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 396595000546 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595000547 Walker A/P-loop; other site 396595000548 ATP binding site [chemical binding]; other site 396595000549 Q-loop/lid; other site 396595000550 ABC transporter signature motif; other site 396595000551 Walker B; other site 396595000552 D-loop; other site 396595000553 H-loop/switch region; other site 396595000554 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 396595000555 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 396595000556 spermidine synthase; Provisional; Region: PRK00811 396595000557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595000558 arginine decarboxylase; Provisional; Region: PRK05354 396595000559 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 396595000560 dimer interface [polypeptide binding]; other site 396595000561 active site 396595000562 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 396595000563 catalytic residues [active] 396595000564 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 396595000565 YcgL domain; Region: YcgL; cl01189 396595000566 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 396595000567 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 396595000568 G1 box; other site 396595000569 putative GEF interaction site [polypeptide binding]; other site 396595000570 GTP/Mg2+ binding site [chemical binding]; other site 396595000571 Switch I region; other site 396595000572 G2 box; other site 396595000573 G3 box; other site 396595000574 Switch II region; other site 396595000575 G4 box; other site 396595000576 G5 box; other site 396595000577 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 396595000578 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 396595000579 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 396595000580 putative active site [active] 396595000581 Phd_YefM; Region: PhdYeFM; cl09153 396595000582 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 396595000583 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 396595000584 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 396595000585 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 396595000586 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 396595000587 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 396595000588 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 396595000589 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 396595000590 Type II transport protein GspH; Region: GspH; pfam12019 396595000591 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 396595000592 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 396595000593 hypothetical protein; Provisional; Region: PRK10557 396595000594 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 396595000595 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 396595000596 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 396595000597 Transposase; Region: DEDD_Tnp_IS110; pfam01548 396595000598 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 396595000599 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 396595000600 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 396595000601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 396595000602 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 396595000603 catalytic residues [active] 396595000604 Quinolinate synthetase A protein; Region: NadA; cl00420 396595000605 Transposase; Region: DEDD_Tnp_IS110; pfam01548 396595000606 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 396595000607 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 396595000608 putative catalytic residue [active] 396595000609 ferredoxin-NADP reductase; Provisional; Region: PRK10926 396595000610 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 396595000611 FAD binding pocket [chemical binding]; other site 396595000612 FAD binding motif [chemical binding]; other site 396595000613 phosphate binding motif [ion binding]; other site 396595000614 beta-alpha-beta structure motif; other site 396595000615 NAD binding pocket [chemical binding]; other site 396595000616 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 396595000617 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 396595000618 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 396595000619 Cytochrome c; Region: Cytochrom_C; cl11414 396595000620 PilZ domain; Region: PilZ; cl01260 396595000621 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 396595000622 Protein of unknown function (DUF2288); Region: DUF2288; cl02399 396595000623 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 396595000624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595000625 active site 396595000626 phosphorylation site [posttranslational modification] 396595000627 intermolecular recognition site; other site 396595000628 dimerization interface [polypeptide binding]; other site 396595000629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 396595000630 DNA binding site [nucleotide binding] 396595000631 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 396595000632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 396595000633 dimer interface [polypeptide binding]; other site 396595000634 phosphorylation site [posttranslational modification] 396595000635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595000636 ATP binding site [chemical binding]; other site 396595000637 Mg2+ binding site [ion binding]; other site 396595000638 G-X-G motif; other site 396595000639 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 396595000640 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 396595000641 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 396595000642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 396595000643 ATP binding site [chemical binding]; other site 396595000644 putative Mg++ binding site [ion binding]; other site 396595000645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 396595000646 nucleotide binding region [chemical binding]; other site 396595000647 ATP-binding site [chemical binding]; other site 396595000648 Helicase associated domain (HA2); Region: HA2; cl04503 396595000649 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 396595000650 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 396595000651 Sporulation related domain; Region: SPOR; cl10051 396595000652 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 396595000653 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 396595000654 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 396595000655 active site 396595000656 HIGH motif; other site 396595000657 nucleotide binding site [chemical binding]; other site 396595000658 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 396595000659 KMSK motif region; other site 396595000660 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 396595000661 tRNA binding surface [nucleotide binding]; other site 396595000662 anticodon binding site; other site 396595000663 primosome assembly protein PriA; Validated; Region: PRK05580 396595000664 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 396595000665 ATP binding site [chemical binding]; other site 396595000666 putative Mg++ binding site [ion binding]; other site 396595000667 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 396595000668 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 396595000669 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 396595000670 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 396595000671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595000672 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 396595000673 active site 396595000674 ferrochelatase; Reviewed; Region: hemH; PRK00035 396595000675 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 396595000676 C-terminal domain interface [polypeptide binding]; other site 396595000677 active site 396595000678 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 396595000679 active site 396595000680 N-terminal domain interface [polypeptide binding]; other site 396595000681 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 396595000682 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 396595000683 putative MPT binding site; other site 396595000684 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 396595000685 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 396595000686 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 396595000687 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 396595000688 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 396595000689 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl09966 396595000690 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 396595000691 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 396595000692 putative transposase OrfB; Reviewed; Region: PHA02517 396595000693 Integrase core domain; Region: rve; cl01316 396595000694 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 396595000695 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 396595000696 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 396595000697 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 396595000698 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 396595000699 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 396595000700 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 396595000701 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 396595000702 DNA binding residues [nucleotide binding] 396595000703 DNA primase; Validated; Region: dnaG; PRK05667 396595000704 CHC2 zinc finger; Region: zf-CHC2; cl02597 396595000705 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 396595000706 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 396595000707 active site 396595000708 metal binding site [ion binding]; metal-binding site 396595000709 interdomain interaction site; other site 396595000710 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 396595000711 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 396595000712 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 396595000713 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 396595000714 active site 396595000715 dimer interface [polypeptide binding]; other site 396595000716 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 396595000717 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 396595000718 active site 396595000719 FMN binding site [chemical binding]; other site 396595000720 substrate binding site [chemical binding]; other site 396595000721 3Fe-4S cluster binding site [ion binding]; other site 396595000722 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 396595000723 domain interface; other site 396595000724 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595000725 Sporulation related domain; Region: SPOR; cl10051 396595000726 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 396595000727 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 396595000728 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 396595000729 active site 396595000730 dimer interface [polypeptide binding]; other site 396595000731 metal binding site [ion binding]; metal-binding site 396595000732 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 396595000733 GatB domain; Region: GatB_Yqey; cl11497 396595000734 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 396595000735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595000736 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 396595000737 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 396595000738 substrate binding site [chemical binding]; other site 396595000739 active site 396595000740 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 396595000741 Transglycosylase; Region: Transgly; cl07896 396595000742 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 396595000743 Competence protein A; Region: Competence_A; pfam11104 396595000744 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 396595000745 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 396595000746 Pilus assembly protein, PilO; Region: PilO; cl01234 396595000747 Pilus assembly protein, PilP; Region: PilP; cl01235 396595000748 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 396595000749 Secretin and TonB N terminus short domain; Region: STN; cl06624 396595000750 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 396595000751 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 396595000752 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 396595000753 ADP binding site [chemical binding]; other site 396595000754 magnesium binding site [ion binding]; other site 396595000755 putative shikimate binding site; other site 396595000756 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 396595000757 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 396595000758 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 396595000759 substrate binding site [chemical binding]; other site 396595000760 ATP binding site [chemical binding]; other site 396595000761 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 396595000762 catalytic residues [active] 396595000763 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 396595000764 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 396595000765 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 396595000766 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 396595000767 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 396595000768 DsbD alpha interface [polypeptide binding]; other site 396595000769 catalytic residues [active] 396595000770 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 396595000771 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 396595000772 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 396595000773 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 396595000774 Outer membrane efflux protein; Region: OEP; pfam02321 396595000775 Outer membrane efflux protein; Region: OEP; pfam02321 396595000776 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon...; Region: SoxW; cd02951 396595000777 catalytic residues [active] 396595000778 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 396595000779 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 396595000780 oligomerisation interface [polypeptide binding]; other site 396595000781 mobile loop; other site 396595000782 roof hairpin; other site 396595000783 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 396595000784 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 396595000785 ring oligomerisation interface [polypeptide binding]; other site 396595000786 ATP/Mg binding site [chemical binding]; other site 396595000787 stacking interactions; other site 396595000788 hinge regions; other site 396595000789 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 396595000790 ligand binding site [chemical binding]; other site 396595000791 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 396595000792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 396595000793 Family of unknown function (DUF490); Region: DUF490; pfam04357 396595000794 Family of unknown function (DUF490); Region: DUF490; pfam04357 396595000795 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 396595000796 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 396595000797 Surface antigen; Region: Bac_surface_Ag; cl03097 396595000798 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 396595000799 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 396595000800 Walker A/P-loop; other site 396595000801 ATP binding site [chemical binding]; other site 396595000802 Q-loop/lid; other site 396595000803 ABC transporter signature motif; other site 396595000804 Walker B; other site 396595000805 D-loop; other site 396595000806 H-loop/switch region; other site 396595000807 TOBE domain; Region: TOBE_2; cl01440 396595000808 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 396595000809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 396595000810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 396595000811 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 396595000812 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 396595000813 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 396595000814 metal binding triad; other site 396595000815 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 396595000816 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 396595000817 metal binding triad; other site 396595000818 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 396595000819 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 396595000820 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 396595000821 homodimer interface [polypeptide binding]; other site 396595000822 substrate-cofactor binding pocket; other site 396595000823 catalytic residue [active] 396595000824 Zinc-finger domain; Region: zf-CHCC; cl01821 396595000825 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 396595000826 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 396595000827 putative ribose interaction site [chemical binding]; other site 396595000828 putative ADP binding site [chemical binding]; other site 396595000829 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 396595000830 active site 396595000831 HIGH motif; other site 396595000832 nucleotide binding site [chemical binding]; other site 396595000833 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 396595000834 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 396595000835 NADP binding site [chemical binding]; other site 396595000836 homopentamer interface [polypeptide binding]; other site 396595000837 substrate binding site [chemical binding]; other site 396595000838 active site 396595000839 Protein of unknown function (DUF2843); Region: DUF2843; pfam11004 396595000840 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 396595000841 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 396595000842 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 396595000843 putative active site [active] 396595000844 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 396595000845 putative acyl-acceptor binding pocket; other site 396595000846 Mn2+-dependent serine/threonine protein kinase [Signal transduction mechanisms]; Region: COG3642 396595000847 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 396595000848 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 396595000849 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 396595000850 Walker A/P-loop; other site 396595000851 ATP binding site [chemical binding]; other site 396595000852 Q-loop/lid; other site 396595000853 ABC transporter signature motif; other site 396595000854 Walker B; other site 396595000855 D-loop; other site 396595000856 H-loop/switch region; other site 396595000857 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 396595000858 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 396595000859 active site 396595000860 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 396595000861 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 396595000862 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 396595000863 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 396595000864 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 396595000865 putative active site [active] 396595000866 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 396595000867 active site 396595000868 ATP binding site [chemical binding]; other site 396595000869 substrate binding site [chemical binding]; other site 396595000870 activation loop (A-loop); other site 396595000871 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 396595000872 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 396595000873 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 396595000874 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 396595000875 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 396595000876 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 396595000877 putative active site [active] 396595000878 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 396595000879 dimer interface [polypeptide binding]; other site 396595000880 active site 396595000881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 396595000882 active site 396595000883 motif I; other site 396595000884 motif II; other site 396595000885 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 396595000886 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 396595000887 SprT homologues; Region: SprT; cl01182 396595000888 ribonuclease D; Region: rnd; TIGR01388 396595000889 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 396595000890 putative active site [active] 396595000891 catalytic site [active] 396595000892 putative substrate binding site [chemical binding]; other site 396595000893 HRDC domain; Region: HRDC; cl02578 396595000894 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 396595000895 rod shape-determining protein MreD; Region: MreD; cl01087 396595000896 rod shape-determining protein MreC; Provisional; Region: PRK13922 396595000897 rod shape-determining protein MreC; Region: MreC; pfam04085 396595000898 rod shape-determining protein MreB; Provisional; Region: PRK13927 396595000899 Cell division protein FtsA; Region: FtsA; cl11496 396595000900 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 396595000901 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 396595000902 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 396595000903 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 396595000904 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 396595000905 GatB domain; Region: GatB_Yqey; cl11497 396595000906 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 396595000907 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 396595000908 dimerization interface [polypeptide binding]; other site 396595000909 domain crossover interface; other site 396595000910 redox-dependent activation switch; other site 396595000911 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 396595000912 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 396595000913 ATP binding site [chemical binding]; other site 396595000914 substrate interface [chemical binding]; other site 396595000915 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 396595000916 Transposase; Region: DDE_Tnp_ISL3; pfam01610 396595000917 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 396595000918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595000919 S-adenosylmethionine binding site [chemical binding]; other site 396595000920 peptide chain release factor 1; Validated; Region: prfA; PRK00591 396595000921 RF-1 domain; Region: RF-1; cl02875 396595000922 RF-1 domain; Region: RF-1; cl02875 396595000923 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 396595000924 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 396595000925 tRNA; other site 396595000926 putative tRNA binding site [nucleotide binding]; other site 396595000927 putative NADP binding site [chemical binding]; other site 396595000928 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 396595000929 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 396595000930 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595000931 binding surface 396595000932 TPR motif; other site 396595000933 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595000934 binding surface 396595000935 TPR motif; other site 396595000936 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 396595000937 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 396595000938 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 396595000939 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 396595000940 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923 396595000941 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 396595000942 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 396595000943 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 396595000944 5S rRNA interface [nucleotide binding]; other site 396595000945 CTC domain interface [polypeptide binding]; other site 396595000946 L16 interface [polypeptide binding]; other site 396595000947 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 396595000948 putative active site [active] 396595000949 catalytic residue [active] 396595000950 GTP-binding protein YchF; Reviewed; Region: PRK09601 396595000951 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 396595000952 G1 box; other site 396595000953 GTP/Mg2+ binding site [chemical binding]; other site 396595000954 Switch I region; other site 396595000955 G2 box; other site 396595000956 Switch II region; other site 396595000957 G3 box; other site 396595000958 G4 box; other site 396595000959 G5 box; other site 396595000960 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 396595000961 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 396595000962 putative GSH binding site [chemical binding]; other site 396595000963 catalytic residues [active] 396595000964 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 396595000965 active site 396595000966 catalytic site [active] 396595000967 substrate binding site [chemical binding]; other site 396595000968 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 396595000969 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 396595000970 dimer interface [polypeptide binding]; other site 396595000971 TPP-binding site [chemical binding]; other site 396595000972 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 396595000973 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 396595000974 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 396595000975 E3 interaction surface; other site 396595000976 lipoyl attachment site [posttranslational modification]; other site 396595000977 e3 binding domain; Region: E3_binding; pfam02817 396595000978 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 396595000979 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 396595000980 E3 interaction surface; other site 396595000981 lipoyl attachment site [posttranslational modification]; other site 396595000982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595000983 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 396595000984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595000985 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 396595000986 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 396595000987 ligand binding site [chemical binding]; other site 396595000988 argininosuccinate synthase; Provisional; Region: PLN00200 396595000989 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 396595000990 ANP binding site [chemical binding]; other site 396595000991 Substrate Binding Site II [chemical binding]; other site 396595000992 Substrate Binding Site I [chemical binding]; other site 396595000993 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 396595000994 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 396595000995 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 396595000996 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595000997 metal binding site [ion binding]; metal-binding site 396595000998 active site 396595000999 I-site; other site 396595001000 VacJ like lipoprotein; Region: VacJ; cl01073 396595001001 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 396595001002 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 396595001003 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 396595001004 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 396595001005 aromatic acid decarboxylase; Validated; Region: PRK05920 396595001006 Flavoprotein; Region: Flavoprotein; cl08021 396595001007 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 396595001008 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 396595001009 catalytic residues [active] 396595001010 Membrane transport protein; Region: Mem_trans; cl09117 396595001011 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 396595001012 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 396595001013 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 396595001014 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 396595001015 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 396595001016 putative active site [active] 396595001017 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 396595001018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 396595001019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 396595001020 OstA-like protein; Region: OstA; cl00844 396595001021 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 396595001022 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 396595001023 Walker A/P-loop; other site 396595001024 ATP binding site [chemical binding]; other site 396595001025 Q-loop/lid; other site 396595001026 ABC transporter signature motif; other site 396595001027 Walker B; other site 396595001028 D-loop; other site 396595001029 H-loop/switch region; other site 396595001030 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 396595001031 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 396595001032 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 396595001033 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 396595001034 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 396595001035 30S subunit binding site; other site 396595001036 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 396595001037 active site 396595001038 phosphorylation site [posttranslational modification] 396595001039 HPr kinase/phosphorylase; Provisional; Region: PRK05428 396595001040 DRTGG domain; Region: DRTGG; cl12147 396595001041 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 396595001042 Hpr binding site; other site 396595001043 active site 396595001044 homohexamer subunit interaction site [polypeptide binding]; other site 396595001045 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595001046 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 396595001047 active pocket/dimerization site; other site 396595001048 active site 396595001049 phosphorylation site [posttranslational modification] 396595001050 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 396595001051 dimerization domain swap beta strand [polypeptide binding]; other site 396595001052 regulatory protein interface [polypeptide binding]; other site 396595001053 active site 396595001054 regulatory phosphorylation site [posttranslational modification]; other site 396595001055 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 396595001056 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 396595001057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595001058 homodimer interface [polypeptide binding]; other site 396595001059 catalytic residue [active] 396595001060 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 396595001061 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 396595001062 NAD binding site [chemical binding]; other site 396595001063 dimerization interface [polypeptide binding]; other site 396595001064 product binding site; other site 396595001065 substrate binding site [chemical binding]; other site 396595001066 zinc binding site [ion binding]; other site 396595001067 catalytic residues [active] 396595001068 NeuB family; Region: NeuB; cl00496 396595001069 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 396595001070 ATP phosphoribosyltransferase; Region: HisG; cl15266 396595001071 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 396595001072 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 396595001073 hinge; other site 396595001074 active site 396595001075 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 396595001076 anti sigma factor interaction site; other site 396595001077 regulatory phosphorylation site [posttranslational modification]; other site 396595001078 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074 396595001079 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 396595001080 mce related protein; Region: MCE; pfam02470 396595001081 Domain of unknown function DUF140; Region: DUF140; cl00510 396595001082 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 396595001083 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 396595001084 Walker A/P-loop; other site 396595001085 ATP binding site [chemical binding]; other site 396595001086 Q-loop/lid; other site 396595001087 ABC transporter signature motif; other site 396595001088 Walker B; other site 396595001089 D-loop; other site 396595001090 H-loop/switch region; other site 396595001091 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 396595001092 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 396595001093 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 396595001094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595001095 NAD(P) binding site [chemical binding]; other site 396595001096 active site 396595001097 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 396595001098 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 396595001099 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 396595001100 inhibitor-cofactor binding pocket; inhibition site 396595001101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595001102 catalytic residue [active] 396595001103 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 396595001104 thiamine phosphate binding site [chemical binding]; other site 396595001105 active site 396595001106 pyrophosphate binding site [ion binding]; other site 396595001107 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 396595001108 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 396595001109 dimer interface [polypeptide binding]; other site 396595001110 substrate binding site [chemical binding]; other site 396595001111 ATP binding site [chemical binding]; other site 396595001112 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 396595001113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 396595001114 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671 396595001115 putative active site [active] 396595001116 Ap4A binding site [chemical binding]; other site 396595001117 nudix motif; other site 396595001118 putative metal binding site [ion binding]; other site 396595001119 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 396595001120 GAF domain; Region: GAF; cl00853 396595001121 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 396595001122 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 396595001123 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 396595001124 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 396595001125 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 396595001126 catalytic residues [active] 396595001127 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 396595001128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595001129 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 396595001130 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 396595001131 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 396595001132 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 396595001133 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 396595001134 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 396595001135 active site 396595001136 HIGH motif; other site 396595001137 dimer interface [polypeptide binding]; other site 396595001138 KMSKS motif; other site 396595001139 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 396595001140 RNA binding surface [nucleotide binding]; other site 396595001141 Transposase, Mutator family; Region: Transposase_mut; pfam00872 396595001142 MULE transposase domain; Region: MULE; pfam10551 396595001143 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 396595001144 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 396595001145 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 396595001146 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 396595001147 dihydrodipicolinate synthase; Region: dapA; TIGR00674 396595001148 dimer interface [polypeptide binding]; other site 396595001149 active site 396595001150 catalytic residue [active] 396595001151 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 396595001152 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 396595001153 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 396595001154 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 396595001155 catalytic triad [active] 396595001156 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 396595001157 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 396595001158 putative active site [active] 396595001159 PhoH-like protein; Region: PhoH; cl12134 396595001160 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 396595001161 active site 396595001162 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 396595001163 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 396595001164 TPP-binding site; other site 396595001165 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 396595001166 PYR/PP interface [polypeptide binding]; other site 396595001167 dimer interface [polypeptide binding]; other site 396595001168 TPP binding site [chemical binding]; other site 396595001169 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 396595001170 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 396595001171 substrate binding pocket [chemical binding]; other site 396595001172 chain length determination region; other site 396595001173 substrate-Mg2+ binding site; other site 396595001174 catalytic residues [active] 396595001175 aspartate-rich region 1; other site 396595001176 active site lid residues [active] 396595001177 aspartate-rich region 2; other site 396595001178 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 396595001179 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 396595001180 Ferritin-like domain; Region: Ferritin; pfam00210 396595001181 binuclear metal center [ion binding]; other site 396595001182 tricarballylate utilization protein B; Provisional; Region: PRK15033 396595001183 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 396595001184 Uncharacterized conserved protein [Function unknown]; Region: COG3461 396595001185 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 396595001186 Transposase; Region: DEDD_Tnp_IS110; pfam01548 396595001187 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 396595001188 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 396595001189 DNA repair protein RadA; Provisional; Region: PRK11823 396595001190 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 396595001191 Walker A motif/ATP binding site; other site 396595001192 ATP binding site [chemical binding]; other site 396595001193 Walker B motif; other site 396595001194 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 396595001195 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 396595001196 Domain of unknown function DUF21; Region: DUF21; pfam01595 396595001197 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 396595001198 Transporter associated domain; Region: CorC_HlyC; cl08393 396595001199 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 396595001200 signal recognition particle protein; Provisional; Region: PRK10867 396595001201 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 396595001202 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 396595001203 P loop; other site 396595001204 GTP binding site [chemical binding]; other site 396595001205 Signal peptide binding domain; Region: SRP_SPB; pfam02978 396595001206 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 396595001207 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 396595001208 RimM N-terminal domain; Region: RimM; pfam01782 396595001209 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 396595001210 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 396595001211 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 396595001212 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 396595001213 active site 396595001214 DNA binding site [nucleotide binding] 396595001215 Cytochrome c [Energy production and conversion]; Region: COG3258 396595001216 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 396595001217 Cytochrome c; Region: Cytochrom_C; cl11414 396595001218 heat shock protein 90; Provisional; Region: PRK05218 396595001219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 396595001220 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 396595001221 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 396595001222 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 396595001223 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 396595001224 Gram-negative bacterial tonB protein; Region: TonB; cl10048 396595001225 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 396595001226 Ferritin-like domain; Region: Ferritin; pfam00210 396595001227 heme binding site [chemical binding]; other site 396595001228 ferroxidase pore; other site 396595001229 ferroxidase diiron center [ion binding]; other site 396595001230 Hemin uptake protein hemP; Region: hemP; cl10043 396595001231 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 396595001232 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 396595001233 N-terminal plug; other site 396595001234 ligand-binding site [chemical binding]; other site 396595001235 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 396595001236 Sel1 repeat; Region: Sel1; cl02723 396595001237 Sel1 repeat; Region: Sel1; cl02723 396595001238 Flagellin N-methylase; Region: FliB; cl00497 396595001239 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 396595001240 putative active site pocket [active] 396595001241 dimerization interface [polypeptide binding]; other site 396595001242 putative catalytic residue [active] 396595001243 recombination and repair protein; Provisional; Region: PRK10869 396595001244 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 396595001245 Walker A/P-loop; other site 396595001246 ATP binding site [chemical binding]; other site 396595001247 Q-loop/lid; other site 396595001248 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 396595001249 ABC transporter signature motif; other site 396595001250 Walker B; other site 396595001251 D-loop; other site 396595001252 H-loop/switch region; other site 396595001253 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 396595001254 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 396595001255 HrcA protein C terminal domain; Region: HrcA; pfam01628 396595001256 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 396595001257 dimer interface [polypeptide binding]; other site 396595001258 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 396595001259 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 396595001260 chaperone protein DnaJ; Provisional; Region: PRK10767 396595001261 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 396595001262 HSP70 interaction site [polypeptide binding]; other site 396595001263 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 396595001264 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 396595001265 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 396595001266 PAS domain S-box; Region: sensory_box; TIGR00229 396595001267 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595001268 metal binding site [ion binding]; metal-binding site 396595001269 active site 396595001270 I-site; other site 396595001271 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595001272 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 396595001273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 396595001274 FeS/SAM binding site; other site 396595001275 elongation factor P; Validated; Region: PRK00529 396595001276 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 396595001277 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 396595001278 RNA binding site [nucleotide binding]; other site 396595001279 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 396595001280 RNA binding site [nucleotide binding]; other site 396595001281 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 396595001282 lysyl-tRNA synthetase-like protein GenX; Region: genX; TIGR00462 396595001283 motif 1; other site 396595001284 dimer interface [polypeptide binding]; other site 396595001285 active site 396595001286 motif 2; other site 396595001287 motif 3; other site 396595001288 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 396595001289 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 396595001290 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 396595001291 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 396595001292 Ligand binding site [chemical binding]; other site 396595001293 Putative Catalytic site [active] 396595001294 DXD motif; other site 396595001295 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 396595001296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595001297 NAD(P) binding site [chemical binding]; other site 396595001298 active site 396595001299 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 396595001300 active site 2 [active] 396595001301 active site 1 [active] 396595001302 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 396595001303 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 396595001304 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 396595001305 dimer interface [polypeptide binding]; other site 396595001306 active site 396595001307 Predicted exporter [General function prediction only]; Region: COG4258 396595001308 Predicted acyltransferase [General function prediction only]; Region: COG4261 396595001309 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 396595001310 putative acyl-acceptor binding pocket; other site 396595001311 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 396595001312 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 396595001313 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 396595001314 Predicted membrane protein [Function unknown]; Region: COG4648 396595001315 Phosphopantetheine attachment site; Region: PP-binding; cl09936 396595001316 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 396595001317 putative active site [active] 396595001318 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 396595001319 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 396595001320 active site 396595001321 HIGH motif; other site 396595001322 nucleotide binding site [chemical binding]; other site 396595001323 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 396595001324 active site 396595001325 KMSKS motif; other site 396595001326 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 396595001327 tRNA binding surface [nucleotide binding]; other site 396595001328 anticodon binding site; other site 396595001329 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 396595001330 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 396595001331 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 396595001332 putative NAD(P) binding site [chemical binding]; other site 396595001333 hypothetical protein; Provisional; Region: PRK04233 396595001334 SEC-C motif; Region: SEC-C; cl12132 396595001335 DNA-J related protein; Region: DNAJ_related; pfam12339 396595001336 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 396595001337 HSP70 interaction site [polypeptide binding]; other site 396595001338 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 396595001339 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 396595001340 FAD binding pocket [chemical binding]; other site 396595001341 FAD binding motif [chemical binding]; other site 396595001342 phosphate binding motif [ion binding]; other site 396595001343 beta-alpha-beta structure motif; other site 396595001344 NAD binding pocket [chemical binding]; other site 396595001345 PAS domain S-box; Region: sensory_box; TIGR00229 396595001346 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595001347 putative active site [active] 396595001348 heme pocket [chemical binding]; other site 396595001349 hypothetical protein; Provisional; Region: PRK13560 396595001350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 396595001351 sensory histidine kinase AtoS; Provisional; Region: PRK11360 396595001352 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595001353 metal binding site [ion binding]; metal-binding site 396595001354 active site 396595001355 I-site; other site 396595001356 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595001357 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 396595001358 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 396595001359 putative carbohydrate kinase; Provisional; Region: PRK10565 396595001360 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 396595001361 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 396595001362 putative substrate binding site [chemical binding]; other site 396595001363 putative ATP binding site [chemical binding]; other site 396595001364 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 396595001365 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 396595001366 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 396595001367 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 396595001368 active site 396595001369 metal binding site [ion binding]; metal-binding site 396595001370 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 396595001371 putative peptidoglycan binding site; other site 396595001372 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 396595001373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595001374 ATP binding site [chemical binding]; other site 396595001375 Mg2+ binding site [ion binding]; other site 396595001376 G-X-G motif; other site 396595001377 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 396595001378 ATP binding site [chemical binding]; other site 396595001379 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 396595001380 IPP transferase; Region: IPPT; cl00403 396595001381 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 396595001382 Sm1 motif; other site 396595001383 intra - hexamer interaction site; other site 396595001384 inter - hexamer interaction site [polypeptide binding]; other site 396595001385 nucleotide binding pocket [chemical binding]; other site 396595001386 Sm2 motif; other site 396595001387 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 396595001388 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 396595001389 G1 box; other site 396595001390 GTP/Mg2+ binding site [chemical binding]; other site 396595001391 Switch I region; other site 396595001392 G2 box; other site 396595001393 G3 box; other site 396595001394 Switch II region; other site 396595001395 G4 box; other site 396595001396 G5 box; other site 396595001397 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 396595001398 N-acetyl-D-glucosamine binding site [chemical binding]; other site 396595001399 catalytic residue [active] 396595001400 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 396595001401 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 396595001402 putative peptidoglycan binding site; other site 396595001403 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 396595001404 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 396595001405 putative peptidoglycan binding site; other site 396595001406 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 396595001407 putative peptidoglycan binding site; other site 396595001408 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 396595001409 RNA/DNA hybrid binding site [nucleotide binding]; other site 396595001410 active site 396595001411 Proteobacterial; Region: dnaQ_proteo; TIGR01406 396595001412 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 396595001413 active site 396595001414 substrate binding site [chemical binding]; other site 396595001415 catalytic site [active] 396595001416 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 396595001417 transmembrane helices; other site 396595001418 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 396595001419 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 396595001420 prolyl-tRNA synthetase; Provisional; Region: PRK09194 396595001421 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 396595001422 dimer interface [polypeptide binding]; other site 396595001423 motif 1; other site 396595001424 active site 396595001425 motif 2; other site 396595001426 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 396595001427 putative deacylase active site [active] 396595001428 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 396595001429 active site 396595001430 motif 3; other site 396595001431 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 396595001432 anticodon binding site; other site 396595001433 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 396595001434 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 396595001435 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 396595001436 Protein export membrane protein; Region: SecD_SecF; cl14618 396595001437 Nucleoside recognition; Region: Gate; cl00486 396595001438 Nucleoside recognition; Region: Gate; cl00486 396595001439 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 396595001440 short chain dehydrogenase; Provisional; Region: PRK05693 396595001441 NADP binding site [chemical binding]; other site 396595001442 active site 396595001443 steroid binding site; other site 396595001444 DsrE/DsrF-like family; Region: DrsE; cl00672 396595001445 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 396595001446 Protein of unknown function (DUF502); Region: DUF502; cl01107 396595001447 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 396595001448 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 396595001449 dimer interface [polypeptide binding]; other site 396595001450 anticodon binding site; other site 396595001451 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 396595001452 homodimer interface [polypeptide binding]; other site 396595001453 motif 1; other site 396595001454 active site 396595001455 motif 2; other site 396595001456 GAD domain; Region: GAD; pfam02938 396595001457 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 396595001458 active site 396595001459 motif 3; other site 396595001460 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 396595001461 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 396595001462 PAS fold; Region: PAS_3; pfam08447 396595001463 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 396595001464 PAS domain S-box; Region: sensory_box; TIGR00229 396595001465 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 396595001466 PAS fold; Region: PAS_4; pfam08448 396595001467 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595001468 metal binding site [ion binding]; metal-binding site 396595001469 active site 396595001470 I-site; other site 396595001471 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595001472 High potential iron-sulfur protein; Region: HIPIP; pfam01355 396595001473 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 396595001474 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 396595001475 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 396595001476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 396595001477 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 396595001478 GAF domain; Region: GAF; cl00853 396595001479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595001480 metal binding site [ion binding]; metal-binding site 396595001481 active site 396595001482 I-site; other site 396595001483 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595001484 Cytochrome c; Region: Cytochrom_C; cl11414 396595001485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595001486 Predicted permease; Region: DUF318; cl00487 396595001487 Predicted permease; Region: DUF318; cl00487 396595001488 Copper resistance protein D; Region: CopD; cl00563 396595001489 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 396595001490 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 396595001491 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595001492 PAS fold; Region: PAS_3; pfam08447 396595001493 putative active site [active] 396595001494 heme pocket [chemical binding]; other site 396595001495 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595001496 metal binding site [ion binding]; metal-binding site 396595001497 active site 396595001498 I-site; other site 396595001499 PAS domain S-box; Region: sensory_box; TIGR00229 396595001500 GAF domain; Region: GAF; cl00853 396595001501 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595001502 metal binding site [ion binding]; metal-binding site 396595001503 active site 396595001504 I-site; other site 396595001505 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595001506 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 396595001507 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 396595001508 putative active site [active] 396595001509 catalytic site [active] 396595001510 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 396595001511 putative active site [active] 396595001512 catalytic site [active] 396595001513 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 396595001514 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 396595001515 CAP-like domain; other site 396595001516 Active site [active] 396595001517 primary dimer interface [polypeptide binding]; other site 396595001518 Response regulator receiver domain; Region: Response_reg; pfam00072 396595001519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595001520 active site 396595001521 phosphorylation site [posttranslational modification] 396595001522 intermolecular recognition site; other site 396595001523 dimerization interface [polypeptide binding]; other site 396595001524 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595001525 metal binding site [ion binding]; metal-binding site 396595001526 active site 396595001527 I-site; other site 396595001528 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595001529 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 396595001530 GAF domain; Region: GAF; cl00853 396595001531 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 396595001532 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595001533 putative active site [active] 396595001534 heme pocket [chemical binding]; other site 396595001535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 396595001536 dimer interface [polypeptide binding]; other site 396595001537 phosphorylation site [posttranslational modification] 396595001538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595001539 ATP binding site [chemical binding]; other site 396595001540 Mg2+ binding site [ion binding]; other site 396595001541 G-X-G motif; other site 396595001542 Response regulator receiver domain; Region: Response_reg; pfam00072 396595001543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595001544 active site 396595001545 phosphorylation site [posttranslational modification] 396595001546 intermolecular recognition site; other site 396595001547 dimerization interface [polypeptide binding]; other site 396595001548 Peptidase family M48; Region: Peptidase_M48; cl12018 396595001549 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 396595001550 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 396595001551 dimer interface [polypeptide binding]; other site 396595001552 phosphorylation site [posttranslational modification] 396595001553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595001554 ATP binding site [chemical binding]; other site 396595001555 Mg2+ binding site [ion binding]; other site 396595001556 G-X-G motif; other site 396595001557 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 396595001558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595001559 active site 396595001560 phosphorylation site [posttranslational modification] 396595001561 intermolecular recognition site; other site 396595001562 dimerization interface [polypeptide binding]; other site 396595001563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595001564 Walker A motif; other site 396595001565 ATP binding site [chemical binding]; other site 396595001566 Walker B motif; other site 396595001567 arginine finger; other site 396595001568 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 396595001569 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 396595001570 23S rRNA interface [nucleotide binding]; other site 396595001571 L3 interface [polypeptide binding]; other site 396595001572 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 396595001573 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 396595001574 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 396595001575 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 396595001576 FAD binding domain; Region: FAD_binding_4; pfam01565 396595001577 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 396595001578 Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150 396595001579 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 396595001580 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 396595001581 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 396595001582 active site residue [active] 396595001583 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 396595001584 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 396595001585 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 396595001586 tetramer (dimer of dimers) interface [polypeptide binding]; other site 396595001587 active site 396595001588 dimer interface [polypeptide binding]; other site 396595001589 threonine dehydratase; Reviewed; Region: PRK09224 396595001590 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 396595001591 tetramer interface [polypeptide binding]; other site 396595001592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595001593 catalytic residue [active] 396595001594 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 396595001595 putative Ile/Val binding site [chemical binding]; other site 396595001596 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 396595001597 putative Ile/Val binding site [chemical binding]; other site 396595001598 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 396595001599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595001600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595001601 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 396595001602 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 396595001603 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 396595001604 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 396595001605 active site 396595001606 substrate binding site [chemical binding]; other site 396595001607 cosubstrate binding site; other site 396595001608 catalytic site [active] 396595001609 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 396595001610 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 396595001611 dimerization interface [polypeptide binding]; other site 396595001612 putative ATP binding site [chemical binding]; other site 396595001613 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; cl01278 396595001614 Domain of unknown function DUF20; Region: UPF0118; cl00465 396595001615 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595001616 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 396595001617 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 396595001618 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 396595001619 catalytic residues [active] 396595001620 Acylphosphatase; Region: Acylphosphatase; cl00551 396595001621 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 396595001622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595001623 Walker A motif; other site 396595001624 ATP binding site [chemical binding]; other site 396595001625 Walker B motif; other site 396595001626 arginine finger; other site 396595001627 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 396595001628 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 396595001629 active site 396595001630 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 396595001631 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 396595001632 Gram-negative bacterial tonB protein; Region: TonB; cl10048 396595001633 translocation protein TolB; Provisional; Region: tolB; PRK04922 396595001634 TolB amino-terminal domain; Region: TolB_N; pfam04052 396595001635 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 396595001636 structural tetrad; other site 396595001637 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 396595001638 ligand binding site [chemical binding]; other site 396595001639 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 396595001640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595001641 binding surface 396595001642 TPR motif; other site 396595001643 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 396595001644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 396595001645 FeS/SAM binding site; other site 396595001646 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 396595001647 Ligand Binding Site [chemical binding]; other site 396595001648 YeeE/YedE family (DUF395); Region: DUF395; cl01018 396595001649 trigger factor; Provisional; Region: tig; PRK01490 396595001650 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 396595001651 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 396595001652 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 396595001653 oligomer interface [polypeptide binding]; other site 396595001654 active site residues [active] 396595001655 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 396595001656 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 396595001657 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595001658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595001659 Walker A motif; other site 396595001660 ATP binding site [chemical binding]; other site 396595001661 Walker B motif; other site 396595001662 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 396595001663 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 396595001664 Found in ATP-dependent protease La (LON); Region: LON; smart00464 396595001665 Found in ATP-dependent protease La (LON); Region: LON; smart00464 396595001666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595001667 Walker A motif; other site 396595001668 ATP binding site [chemical binding]; other site 396595001669 Walker B motif; other site 396595001670 arginine finger; other site 396595001671 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 396595001672 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 396595001673 IHF dimer interface [polypeptide binding]; other site 396595001674 IHF - DNA interface [nucleotide binding]; other site 396595001675 flagellar motor protein MotB; Validated; Region: motB; PRK09041 396595001676 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 396595001677 ligand binding site [chemical binding]; other site 396595001678 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 396595001679 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 396595001680 PAS domain S-box; Region: sensory_box; TIGR00229 396595001681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595001682 putative active site [active] 396595001683 heme pocket [chemical binding]; other site 396595001684 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 396595001685 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 396595001686 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 396595001687 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 396595001688 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 396595001689 2-isopropylmalate synthase; Validated; Region: PRK03739 396595001690 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 396595001691 catalytic motif [active] 396595001692 Catalytic residue [active] 396595001693 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 396595001694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 396595001695 putative substrate translocation pore; other site 396595001696 MarC family integral membrane protein; Region: MarC; cl00919 396595001697 cysteine synthases; Region: cysKM; TIGR01136 396595001698 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 396595001699 dimer interface [polypeptide binding]; other site 396595001700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595001701 catalytic residue [active] 396595001702 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 396595001703 active site 396595001704 catalytic site [active] 396595001705 substrate binding site [chemical binding]; other site 396595001706 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 396595001707 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 396595001708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595001709 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 396595001710 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 396595001711 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 396595001712 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 396595001713 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 396595001714 Trm112p-like protein; Region: Trm112p; cl01066 396595001715 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 396595001716 Ligand binding site [chemical binding]; other site 396595001717 oligomer interface [polypeptide binding]; other site 396595001718 periplasmic folding chaperone; Provisional; Region: PRK10788 396595001719 PPIC-type PPIASE domain; Region: Rotamase; cl08278 396595001720 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 396595001721 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 396595001722 NAD binding site [chemical binding]; other site 396595001723 homotetramer interface [polypeptide binding]; other site 396595001724 homodimer interface [polypeptide binding]; other site 396595001725 substrate binding site [chemical binding]; other site 396595001726 active site 396595001727 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 396595001728 peptide binding site [polypeptide binding]; other site 396595001729 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 396595001730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 396595001731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 396595001732 dimer interface [polypeptide binding]; other site 396595001733 conserved gate region; other site 396595001734 putative PBP binding loops; other site 396595001735 ABC-ATPase subunit interface; other site 396595001736 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 396595001737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 396595001738 dimer interface [polypeptide binding]; other site 396595001739 conserved gate region; other site 396595001740 putative PBP binding loops; other site 396595001741 ABC-ATPase subunit interface; other site 396595001742 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 396595001743 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 396595001744 Walker A/P-loop; other site 396595001745 ATP binding site [chemical binding]; other site 396595001746 Q-loop/lid; other site 396595001747 ABC transporter signature motif; other site 396595001748 Walker B; other site 396595001749 D-loop; other site 396595001750 H-loop/switch region; other site 396595001751 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 396595001752 Walker A/P-loop; other site 396595001753 ATP binding site [chemical binding]; other site 396595001754 Q-loop/lid; other site 396595001755 ABC transporter signature motif; other site 396595001756 Walker B; other site 396595001757 D-loop; other site 396595001758 H-loop/switch region; other site 396595001759 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 396595001760 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 396595001761 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 396595001762 homodimer interface [polypeptide binding]; other site 396595001763 NADP binding site [chemical binding]; other site 396595001764 substrate binding site [chemical binding]; other site 396595001765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595001766 metal binding site [ion binding]; metal-binding site 396595001767 active site 396595001768 I-site; other site 396595001769 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 396595001770 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 396595001771 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 396595001772 NAD(P) binding site [chemical binding]; other site 396595001773 homodimer interface [polypeptide binding]; other site 396595001774 substrate binding site [chemical binding]; other site 396595001775 active site 396595001776 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 396595001777 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine...; Region: GT_WbpL_WbcO_like; cd06854 396595001778 Mg++ binding site [ion binding]; other site 396595001779 putative catalytic motif [active] 396595001780 putative substrate binding site [chemical binding]; other site 396595001781 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 396595001782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595001783 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 396595001784 Bacterial sugar transferase; Region: Bac_transf; cl00939 396595001785 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 396595001786 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 396595001787 putative ADP-binding pocket [chemical binding]; other site 396595001788 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 396595001789 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 396595001790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595001791 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 396595001792 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 396595001793 putative ADP-binding pocket [chemical binding]; other site 396595001794 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 396595001795 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 396595001796 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 396595001797 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 396595001798 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 396595001799 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595001800 Walker A/P-loop; other site 396595001801 ATP binding site [chemical binding]; other site 396595001802 Q-loop/lid; other site 396595001803 ABC transporter signature motif; other site 396595001804 Walker B; other site 396595001805 D-loop; other site 396595001806 H-loop/switch region; other site 396595001807 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 396595001808 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 396595001809 putative NAD(P) binding site [chemical binding]; other site 396595001810 active site 396595001811 putative substrate binding site [chemical binding]; other site 396595001812 polysaccharide export protein Wza; Provisional; Region: PRK15078 396595001813 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 396595001814 Low molecular weight phosphatase family; Region: LMWPc; cd00115 396595001815 Active site [active] 396595001816 Chain length determinant protein; Region: Wzz; cl01623 396595001817 tyrosine kinase; Provisional; Region: PRK11519 396595001818 Chain length determinant protein; Region: Wzz; cl01623 396595001819 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 396595001820 P loop; other site 396595001821 Nucleotide binding site [chemical binding]; other site 396595001822 DTAP/Switch II; other site 396595001823 Switch I; other site 396595001824 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 396595001825 SLBB-domain like (DUF1017); Region: DUF1017; pfam06251 396595001826 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 396595001827 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 396595001828 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 396595001829 active site 396595001830 metal binding site [ion binding]; metal-binding site 396595001831 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 396595001832 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 396595001833 Peptidase family M48; Region: Peptidase_M48; cl12018 396595001834 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 396595001835 active site residue [active] 396595001836 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 396595001837 CPxP motif; other site 396595001838 Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150 396595001839 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 396595001840 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 396595001841 Cysteine-rich domain; Region: CCG; pfam02754 396595001842 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 396595001843 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 396595001844 Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150 396595001845 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 396595001846 Cysteine-rich domain; Region: CCG; pfam02754 396595001847 Cysteine-rich domain; Region: CCG; pfam02754 396595001848 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 396595001849 lipoyl attachment site [posttranslational modification]; other site 396595001850 DsrE/DsrF-like family; Region: DrsE; cl00672 396595001851 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 396595001852 lipoyl attachment site [posttranslational modification]; other site 396595001853 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 396595001854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 396595001855 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 396595001856 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 396595001857 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 396595001858 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 396595001859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 396595001860 FeS/SAM binding site; other site 396595001861 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 396595001862 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 396595001863 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 396595001864 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 396595001865 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595001866 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 396595001867 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 396595001868 metal ion-dependent adhesion site (MIDAS); other site 396595001869 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 396595001870 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 396595001871 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 396595001872 hydrophobic ligand binding site; other site 396595001873 Major Facilitator Superfamily; Region: MFS_1; pfam07690 396595001874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 396595001875 putative substrate translocation pore; other site 396595001876 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 396595001877 G1 box; other site 396595001878 GTP/Mg2+ binding site [chemical binding]; other site 396595001879 Switch I region; other site 396595001880 G2 box; other site 396595001881 Switch II region; other site 396595001882 G3 box; other site 396595001883 G4 box; other site 396595001884 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 396595001885 G1 box; other site 396595001886 GTP/Mg2+ binding site [chemical binding]; other site 396595001887 Switch I region; other site 396595001888 G2 box; other site 396595001889 Switch II region; other site 396595001890 G3 box; other site 396595001891 recombination factor protein RarA; Reviewed; Region: PRK13342 396595001892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595001893 Walker A motif; other site 396595001894 ATP binding site [chemical binding]; other site 396595001895 Walker B motif; other site 396595001896 arginine finger; other site 396595001897 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 396595001898 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 396595001899 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 396595001900 Probable Catalytic site [active] 396595001901 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 396595001902 DsrE/DsrF-like family; Region: DrsE; cl00672 396595001903 Nitrate and nitrite sensing; Region: NIT; pfam08376 396595001904 ANTAR domain; Region: ANTAR; cl04297 396595001905 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 396595001906 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 396595001907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 396595001908 dimer interface [polypeptide binding]; other site 396595001909 conserved gate region; other site 396595001910 putative PBP binding loops; other site 396595001911 ABC-ATPase subunit interface; other site 396595001912 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 396595001913 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 396595001914 Walker A/P-loop; other site 396595001915 ATP binding site [chemical binding]; other site 396595001916 Q-loop/lid; other site 396595001917 ABC transporter signature motif; other site 396595001918 Walker B; other site 396595001919 D-loop; other site 396595001920 H-loop/switch region; other site 396595001921 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 396595001922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595001923 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 396595001924 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 396595001925 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 396595001926 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 396595001927 [2Fe-2S] cluster binding site [ion binding]; other site 396595001928 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 396595001929 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 396595001930 [4Fe-4S] binding site [ion binding]; other site 396595001931 molybdopterin cofactor binding site; other site 396595001932 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 396595001933 molybdopterin cofactor binding site; other site 396595001934 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 396595001935 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 396595001936 siroheme synthase; Provisional; Region: cysG; PRK10637 396595001937 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 396595001938 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 396595001939 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 396595001940 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 396595001941 active site 396595001942 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 396595001943 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 396595001944 High-affinity nickel-transport protein; Region: NicO; cl00964 396595001945 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 396595001946 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 396595001947 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 396595001948 active site 396595001949 HIGH motif; other site 396595001950 nucleotide binding site [chemical binding]; other site 396595001951 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 396595001952 KMSKS motif; other site 396595001953 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 396595001954 tRNA binding surface [nucleotide binding]; other site 396595001955 anticodon binding site; other site 396595001956 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 396595001957 hypothetical protein; Provisional; Region: PRK13560 396595001958 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 396595001959 PAS domain S-box; Region: sensory_box; TIGR00229 396595001960 PAS domain S-box; Region: sensory_box; TIGR00229 396595001961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 396595001962 dimer interface [polypeptide binding]; other site 396595001963 phosphorylation site [posttranslational modification] 396595001964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595001965 ATP binding site [chemical binding]; other site 396595001966 Mg2+ binding site [ion binding]; other site 396595001967 G-X-G motif; other site 396595001968 Response regulator receiver domain; Region: Response_reg; pfam00072 396595001969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595001970 active site 396595001971 phosphorylation site [posttranslational modification] 396595001972 intermolecular recognition site; other site 396595001973 dimerization interface [polypeptide binding]; other site 396595001974 Response regulator receiver domain; Region: Response_reg; pfam00072 396595001975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595001976 active site 396595001977 phosphorylation site [posttranslational modification] 396595001978 intermolecular recognition site; other site 396595001979 dimerization interface [polypeptide binding]; other site 396595001980 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 396595001981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595001982 intermolecular recognition site; other site 396595001983 active site 396595001984 PAS fold; Region: PAS; pfam00989 396595001985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595001986 putative active site [active] 396595001987 heme pocket [chemical binding]; other site 396595001988 GAF domain; Region: GAF; cl00853 396595001989 PAS domain S-box; Region: sensory_box; TIGR00229 396595001990 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595001991 putative active site [active] 396595001992 heme pocket [chemical binding]; other site 396595001993 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595001994 metal binding site [ion binding]; metal-binding site 396595001995 active site 396595001996 I-site; other site 396595001997 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595001998 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 396595001999 The Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily belongs to the M14 family of metallocarboxypeptidases (MCPs), and includes ASTE, which catalyzes the fifth and last step in arginine catabolism by the arginine...; Region: M14_ASTE_ASPA_like; cd06230 396595002000 active site 396595002001 Zn-binding site [ion binding]; other site 396595002002 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 396595002003 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 396595002004 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 396595002005 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 396595002006 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 396595002007 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 396595002008 active site residue [active] 396595002009 sulfite oxidase; Provisional; Region: PLN00177 396595002010 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 396595002011 Moco binding site; other site 396595002012 metal coordination site [ion binding]; other site 396595002013 dimerization interface [polypeptide binding]; other site 396595002014 Cytochrome c; Region: Cytochrom_C; cl11414 396595002015 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 396595002016 THUMP domain; Region: THUMP; cl12076 396595002017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595002018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595002019 ABC-2 type transporter; Region: ABC2_membrane; cl11417 396595002020 nodulation ABC transporter NodI; Provisional; Region: PRK13537 396595002021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595002022 Walker A/P-loop; other site 396595002023 ATP binding site [chemical binding]; other site 396595002024 Q-loop/lid; other site 396595002025 ABC transporter signature motif; other site 396595002026 Walker B; other site 396595002027 D-loop; other site 396595002028 H-loop/switch region; other site 396595002029 DsrE/DsrF-like family; Region: DrsE; cl00672 396595002030 DsrE/DsrF-like family; Region: DrsE; cl00672 396595002031 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 396595002032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595002033 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 396595002034 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 396595002035 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 396595002036 N-acetyl-D-glucosamine binding site [chemical binding]; other site 396595002037 catalytic residue [active] 396595002038 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 396595002039 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 396595002040 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 396595002041 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 396595002042 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 396595002043 catalytic site [active] 396595002044 subunit interface [polypeptide binding]; other site 396595002045 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 396595002046 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 396595002047 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 396595002048 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 396595002049 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 396595002050 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 396595002051 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 396595002052 IMP binding site; other site 396595002053 dimer interface [polypeptide binding]; other site 396595002054 interdomain contacts; other site 396595002055 partial ornithine binding site; other site 396595002056 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 396595002057 domain; Region: GreA_GreB_N; pfam03449 396595002058 C-term; Region: GreA_GreB; pfam01272 396595002059 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 396595002060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595002061 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 396595002062 FtsH Extracellular; Region: FtsH_ext; pfam06480 396595002063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595002064 Walker A motif; other site 396595002065 ATP binding site [chemical binding]; other site 396595002066 Walker B motif; other site 396595002067 arginine finger; other site 396595002068 Peptidase family M41; Region: Peptidase_M41; pfam01434 396595002069 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 396595002070 dihydropteroate synthase; Region: DHPS; TIGR01496 396595002071 substrate binding pocket [chemical binding]; other site 396595002072 dimer interface [polypeptide binding]; other site 396595002073 inhibitor binding site; inhibition site 396595002074 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 396595002075 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 396595002076 active site 396595002077 substrate binding site [chemical binding]; other site 396595002078 metal binding site [ion binding]; metal-binding site 396595002079 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 396595002080 substrate binding site [chemical binding]; other site 396595002081 dimer interface [polypeptide binding]; other site 396595002082 catalytic triad [active] 396595002083 Preprotein translocase SecG subunit; Region: SecG; cl09123 396595002084 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 396595002085 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 396595002086 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 396595002087 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 396595002088 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 396595002089 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 396595002090 putative dimer interface [polypeptide binding]; other site 396595002091 [2Fe-2S] cluster binding site [ion binding]; other site 396595002092 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 396595002093 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 396595002094 SLBB domain; Region: SLBB; pfam10531 396595002095 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 396595002096 NADH dehydrogenase subunit G; Validated; Region: PRK09129 396595002097 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 396595002098 catalytic loop [active] 396595002099 iron binding site [ion binding]; other site 396595002100 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 396595002101 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 396595002102 molybdopterin cofactor binding site; other site 396595002103 NADH dehydrogenase; Region: NADHdh; cl00469 396595002104 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 396595002105 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 396595002106 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 396595002107 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 396595002108 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 396595002109 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 396595002110 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 396595002111 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 396595002112 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 396595002113 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 396595002114 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 396595002115 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 396595002116 ribosome maturation protein RimP; Reviewed; Region: PRK00092 396595002117 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 396595002118 Sm1 motif; other site 396595002119 D3 - B interaction site; other site 396595002120 D1 - D2 interaction site; other site 396595002121 Hfq - Hfq interaction site; other site 396595002122 RNA binding pocket [nucleotide binding]; other site 396595002123 Sm2 motif; other site 396595002124 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 396595002125 NusA N-terminal domain; Region: NusA_N; pfam08529 396595002126 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 396595002127 RNA binding site [nucleotide binding]; other site 396595002128 homodimer interface [polypeptide binding]; other site 396595002129 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 396595002130 G-X-X-G motif; other site 396595002131 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 396595002132 G-X-X-G motif; other site 396595002133 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 396595002134 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 396595002135 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 396595002136 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 396595002137 translation initiation factor IF-2; Region: IF-2; TIGR00487 396595002138 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 396595002139 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 396595002140 G1 box; other site 396595002141 putative GEF interaction site [polypeptide binding]; other site 396595002142 GTP/Mg2+ binding site [chemical binding]; other site 396595002143 Switch I region; other site 396595002144 G2 box; other site 396595002145 G3 box; other site 396595002146 Switch II region; other site 396595002147 G4 box; other site 396595002148 G5 box; other site 396595002149 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 396595002150 Translation-initiation factor 2; Region: IF-2; pfam11987 396595002151 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 396595002152 Ribosome-binding factor A; Region: RBFA; cl00542 396595002153 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 396595002154 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 396595002155 RNA binding site [nucleotide binding]; other site 396595002156 active site 396595002157 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 396595002158 16S/18S rRNA binding site [nucleotide binding]; other site 396595002159 S13e-L30e interaction site [polypeptide binding]; other site 396595002160 25S rRNA binding site [nucleotide binding]; other site 396595002161 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 396595002162 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 396595002163 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 396595002164 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 396595002165 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 396595002166 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 396595002167 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 396595002168 putative nucleic acid binding region [nucleotide binding]; other site 396595002169 G-X-X-G motif; other site 396595002170 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 396595002171 RNA binding site [nucleotide binding]; other site 396595002172 domain interface; other site 396595002173 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 396595002174 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595002175 S-adenosylmethionine binding site [chemical binding]; other site 396595002176 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 396595002177 active site 396595002178 multimer interface [polypeptide binding]; other site 396595002179 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 396595002180 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 396595002181 FeS/SAM binding site; other site 396595002182 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 396595002183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595002184 binding surface 396595002185 TPR motif; other site 396595002186 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 396595002187 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 396595002188 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 396595002189 dimer interface [polypeptide binding]; other site 396595002190 motif 1; other site 396595002191 active site 396595002192 motif 2; other site 396595002193 motif 3; other site 396595002194 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 396595002195 anticodon binding site; other site 396595002196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 396595002197 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 396595002198 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 396595002199 active site 396595002200 GTP-binding protein Der; Reviewed; Region: PRK00093 396595002201 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 396595002202 G1 box; other site 396595002203 GTP/Mg2+ binding site [chemical binding]; other site 396595002204 Switch I region; other site 396595002205 G2 box; other site 396595002206 Switch II region; other site 396595002207 G3 box; other site 396595002208 G4 box; other site 396595002209 G5 box; other site 396595002210 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 396595002211 G1 box; other site 396595002212 GTP/Mg2+ binding site [chemical binding]; other site 396595002213 Switch I region; other site 396595002214 G2 box; other site 396595002215 G3 box; other site 396595002216 Switch II region; other site 396595002217 G4 box; other site 396595002218 G5 box; other site 396595002219 hypothetical protein; Validated; Region: PRK07682 396595002220 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 396595002221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595002222 homodimer interface [polypeptide binding]; other site 396595002223 catalytic residue [active] 396595002224 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 396595002225 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 396595002226 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 396595002227 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 396595002228 phosphoglucomutase; Region: PLN02307 396595002229 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one...; Region: PGM1; cd03085 396595002230 substrate binding site [chemical binding]; other site 396595002231 dimer interface [polypeptide binding]; other site 396595002232 active site 396595002233 metal binding site [ion binding]; metal-binding site 396595002234 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 396595002235 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 396595002236 active site 1 [active] 396595002237 dimer interface [polypeptide binding]; other site 396595002238 active site 2 [active] 396595002239 SH3 domain-containing protein; Provisional; Region: PRK10884 396595002240 Bacterial SH3 domain; Region: SH3_3; cl02551 396595002241 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 396595002242 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 396595002243 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 396595002244 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 396595002245 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 396595002246 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 396595002247 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 396595002248 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 396595002249 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 396595002250 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 396595002251 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 396595002252 dimerization interface [polypeptide binding]; other site 396595002253 putative DNA binding site [nucleotide binding]; other site 396595002254 putative Zn2+ binding site [ion binding]; other site 396595002255 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 396595002256 active site residue [active] 396595002257 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 396595002258 Major Facilitator Superfamily; Region: MFS_1; pfam07690 396595002259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 396595002260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 396595002261 putative substrate translocation pore; other site 396595002262 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 396595002263 ligand binding site [chemical binding]; other site 396595002264 flexible hinge region; other site 396595002265 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 396595002266 putative active site [active] 396595002267 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 396595002268 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 396595002269 YceI-like domain; Region: YceI; cl01001 396595002270 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 396595002271 putative NAD(P) binding site [chemical binding]; other site 396595002272 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 396595002273 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 396595002274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 396595002275 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 396595002276 G1 box; other site 396595002277 GTP/Mg2+ binding site [chemical binding]; other site 396595002278 Switch I region; other site 396595002279 G2 box; other site 396595002280 Switch II region; other site 396595002281 G3 box; other site 396595002282 G4 box; other site 396595002283 DsrE/DsrF-like family; Region: DrsE; cl00672 396595002284 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 396595002285 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 396595002286 active site 396595002287 catalytic tetrad [active] 396595002288 Cupin domain; Region: Cupin_2; cl09118 396595002289 Glutaredoxin 2 [Posttranslational modification, protein turnover, chaperones]; Region: GrxB; COG2999 396595002290 EVE domain; Region: EVE; cl00728 396595002291 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 396595002292 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 396595002293 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 396595002294 active site 396595002295 catalytic tetrad [active] 396595002296 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 396595002297 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 396595002298 Walker A/P-loop; other site 396595002299 ATP binding site [chemical binding]; other site 396595002300 Q-loop/lid; other site 396595002301 ABC transporter signature motif; other site 396595002302 Walker B; other site 396595002303 D-loop; other site 396595002304 H-loop/switch region; other site 396595002305 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 396595002306 Protein of unknown function (DUF2390); Region: DUF2390; cl02376 396595002307 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 396595002308 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 396595002309 ligand binding site [chemical binding]; other site 396595002310 flexible hinge region; other site 396595002311 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 396595002312 putative switch regulator; other site 396595002313 non-specific DNA interactions [nucleotide binding]; other site 396595002314 DNA binding site [nucleotide binding] 396595002315 sequence specific DNA binding site [nucleotide binding]; other site 396595002316 putative cAMP binding site [chemical binding]; other site 396595002317 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 396595002318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595002319 S-adenosylmethionine binding site [chemical binding]; other site 396595002320 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 396595002321 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 396595002322 N-terminal plug; other site 396595002323 ligand-binding site [chemical binding]; other site 396595002324 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 396595002325 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 396595002326 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]; Region: CobN; COG1429 396595002327 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 396595002328 Uncharacterized conserved protein (DUF2149); Region: DUF2149; cl01960 396595002329 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595002330 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 396595002331 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595002332 Walker A motif; other site 396595002333 ATP binding site [chemical binding]; other site 396595002334 Walker B motif; other site 396595002335 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 396595002336 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 396595002337 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 396595002338 catalytic triad [active] 396595002339 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 396595002340 CbiD; Region: CbiD; cl00828 396595002341 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 396595002342 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595002343 Walker A/P-loop; other site 396595002344 ATP binding site [chemical binding]; other site 396595002345 Q-loop/lid; other site 396595002346 ABC transporter signature motif; other site 396595002347 Walker B; other site 396595002348 D-loop; other site 396595002349 H-loop/switch region; other site 396595002350 ABC-2 type transporter; Region: ABC2_membrane; cl11417 396595002351 precorrin-3B synthase; Region: CobG; TIGR02435 396595002352 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 396595002353 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 396595002354 Precorrin-8X methylmutase; Region: CbiC; pfam02570 396595002355 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 396595002356 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 396595002357 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 396595002358 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 396595002359 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 396595002360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595002361 S-adenosylmethionine binding site [chemical binding]; other site 396595002362 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 396595002363 Transposase; Region: DEDD_Tnp_IS110; pfam01548 396595002364 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 396595002365 Cytochrome C'; Region: Cytochrom_C_2; cl01610 396595002366 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 396595002367 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 396595002368 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 396595002369 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 396595002370 HIGH motif; other site 396595002371 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 396595002372 active site 396595002373 KMSKS motif; other site 396595002374 Bacterial transcriptional activator domain; Region: BTAD; smart01043 396595002375 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 396595002376 cyclase homology domain; Region: CHD; cd07302 396595002377 dimer interface [polypeptide binding]; other site 396595002378 metal binding site [ion binding]; metal-binding site 396595002379 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 396595002380 dimer interface [polypeptide binding]; other site 396595002381 active site 396595002382 putative DNA-binding cleft [nucleotide binding]; other site 396595002383 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 396595002384 DsrE/DsrF-like family; Region: DrsE; cl00672 396595002385 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 396595002386 DNA photolyase; Region: DNA_photolyase; pfam00875 396595002387 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 396595002388 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 396595002389 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 396595002390 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 396595002391 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 396595002392 DNA binding residues [nucleotide binding] 396595002393 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 396595002394 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 396595002395 putative transposase OrfB; Reviewed; Region: PHA02517 396595002396 Integrase core domain; Region: rve; cl01316 396595002397 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 396595002398 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 396595002399 active site 396595002400 dimerization interface [polypeptide binding]; other site 396595002401 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 396595002402 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 396595002403 serine O-acetyltransferase; Region: cysE; TIGR01172 396595002404 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 396595002405 trimer interface [polypeptide binding]; other site 396595002406 active site 396595002407 substrate binding site [chemical binding]; other site 396595002408 CoA binding site [chemical binding]; other site 396595002409 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595002410 Rrf2 family protein; Region: rrf2_super; TIGR00738 396595002411 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 396595002412 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 396595002413 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 396595002414 catalytic residue [active] 396595002415 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 396595002416 trimerization site [polypeptide binding]; other site 396595002417 active site 396595002418 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 396595002419 co-chaperone HscB; Provisional; Region: hscB; PRK01773 396595002420 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 396595002421 chaperone protein HscA; Provisional; Region: hscA; PRK05183 396595002422 tellurium resistance terB-like protein; Region: terB_like; cl11965 396595002423 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 396595002424 catalytic loop [active] 396595002425 iron binding site [ion binding]; other site 396595002426 Protein of unknown function (DUF528); Region: DUF528; cl01123 396595002427 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 396595002428 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 396595002429 ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253 396595002430 Walker A/P-loop; other site 396595002431 ATP binding site [chemical binding]; other site 396595002432 Q-loop/lid; other site 396595002433 ABC transporter signature motif; other site 396595002434 Walker B; other site 396595002435 D-loop; other site 396595002436 H-loop/switch region; other site 396595002437 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595002438 metal binding site [ion binding]; metal-binding site 396595002439 active site 396595002440 I-site; other site 396595002441 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 396595002442 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 396595002443 ATP binding site [chemical binding]; other site 396595002444 putative Mg++ binding site [ion binding]; other site 396595002445 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 396595002446 nucleotide binding region [chemical binding]; other site 396595002447 ATP-binding site [chemical binding]; other site 396595002448 RQC domain; Region: RQC; cl09632 396595002449 HRDC domain; Region: HRDC; cl02578 396595002450 Protein of unknown function (DUF3581); Region: DUF3581; pfam12119 396595002451 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 396595002452 Sodium:solute symporter family; Region: SSF; cl00456 396595002453 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 396595002454 Domain of unknown function (DUF897); Region: DUF897; cl01312 396595002455 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 396595002456 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 396595002457 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 396595002458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595002459 active site 396595002460 phosphorylation site [posttranslational modification] 396595002461 intermolecular recognition site; other site 396595002462 dimerization interface [polypeptide binding]; other site 396595002463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595002464 Walker A motif; other site 396595002465 ATP binding site [chemical binding]; other site 396595002466 Walker B motif; other site 396595002467 arginine finger; other site 396595002468 Sodium:solute symporter family; Region: SSF; cl00456 396595002469 sensory histidine kinase AtoS; Provisional; Region: PRK11360 396595002470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 396595002471 dimer interface [polypeptide binding]; other site 396595002472 phosphorylation site [posttranslational modification] 396595002473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595002474 ATP binding site [chemical binding]; other site 396595002475 Mg2+ binding site [ion binding]; other site 396595002476 G-X-G motif; other site 396595002477 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 396595002478 active site 396595002479 HIGH motif; other site 396595002480 nucleotide binding site [chemical binding]; other site 396595002481 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 396595002482 active site 396595002483 KMSKS motif; other site 396595002484 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 396595002485 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 396595002486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 396595002487 motif II; other site 396595002488 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 396595002489 potential catalytic triad [active] 396595002490 conserved cys residue [active] 396595002491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 396595002492 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 396595002493 multidrug efflux protein; Reviewed; Region: PRK09579 396595002494 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 396595002495 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 396595002496 dimer interface [polypeptide binding]; other site 396595002497 catalytic residue [active] 396595002498 metal binding site [ion binding]; metal-binding site 396595002499 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 396595002500 multimerization interface [polypeptide binding]; other site 396595002501 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 396595002502 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 396595002503 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; cl07510 396595002504 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 396595002505 Hexamer/Pentamer interface [polypeptide binding]; other site 396595002506 central pore; other site 396595002507 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 396595002508 Hexamer/Pentamer interface [polypeptide binding]; other site 396595002509 central pore; other site 396595002510 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 396595002511 Hexamer interface [polypeptide binding]; other site 396595002512 Hexagonal pore residue; other site 396595002513 Hexagonal pore; other site 396595002514 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 396595002515 Hexamer interface [polypeptide binding]; other site 396595002516 Hexagonal pore residue; other site 396595002517 Hexagonal pore; other site 396595002518 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 396595002519 Hexamer interface [polypeptide binding]; other site 396595002520 Hexagonal pore residue; other site 396595002521 Hexagonal pore; other site 396595002522 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 396595002523 Ferritin-like domain; Region: Ferritin; pfam00210 396595002524 dinuclear metal binding motif [ion binding]; other site 396595002525 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 396595002526 aromatic arch; other site 396595002527 DCoH dimer interaction site [polypeptide binding]; other site 396595002528 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 396595002529 DCoH tetramer interaction site [polypeptide binding]; other site 396595002530 substrate binding site [chemical binding]; other site 396595002531 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 396595002532 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 396595002533 P-loop; other site 396595002534 Magnesium ion binding site [ion binding]; other site 396595002535 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 396595002536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595002537 Walker A motif; other site 396595002538 ATP binding site [chemical binding]; other site 396595002539 Walker B motif; other site 396595002540 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 396595002541 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 396595002542 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595002543 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 396595002544 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 396595002545 putative dimerization interface [polypeptide binding]; other site 396595002546 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 396595002547 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 396595002548 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 396595002549 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595002550 Walker A/P-loop; other site 396595002551 ATP binding site [chemical binding]; other site 396595002552 Q-loop/lid; other site 396595002553 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 396595002554 ABC transporter signature motif; other site 396595002555 Walker B; other site 396595002556 D-loop; other site 396595002557 ABC transporter; Region: ABC_tran_2; pfam12848 396595002558 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 396595002559 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 396595002560 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 396595002561 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 396595002562 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 396595002563 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 396595002564 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 396595002565 Transposase, Mutator family; Region: Transposase_mut; pfam00872 396595002566 MULE transposase domain; Region: MULE; pfam10551 396595002567 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 396595002568 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 396595002569 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 396595002570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 396595002571 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 396595002572 CrcB-like protein; Region: CRCB; cl09114 396595002573 seryl-tRNA synthetase; Provisional; Region: PRK05431 396595002574 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 396595002575 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 396595002576 dimer interface [polypeptide binding]; other site 396595002577 active site 396595002578 motif 1; other site 396595002579 motif 2; other site 396595002580 motif 3; other site 396595002581 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon...; Region: SoxW; cd02951 396595002582 catalytic residues [active] 396595002583 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 396595002584 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cl00238 396595002585 putative iron binding site [ion binding]; other site 396595002586 Protein of unknown function (DUF423); Region: DUF423; cl01008 396595002587 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 396595002588 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 396595002589 iron-sulfur cluster [ion binding]; other site 396595002590 [2Fe-2S] cluster binding site [ion binding]; other site 396595002591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595002592 glycerate dehydrogenase; Provisional; Region: PRK06487 396595002593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595002594 YccA-like proteins; Region: YccA_like; cd10433 396595002595 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 396595002596 Sulfate transporter family; Region: Sulfate_transp; cl00967 396595002597 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cl03075 396595002598 Sulfate transporter family; Region: Sulfate_transp; cl00967 396595002599 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 396595002600 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 396595002601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595002602 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 396595002603 putative mechanosensitive channel protein; Provisional; Region: PRK11465 396595002604 Mechanosensitive ion channel; Region: MS_channel; pfam00924 396595002605 Transglycosylase; Region: Transgly; cl07896 396595002606 Protein of unknown function, DUF393; Region: DUF393; cl01136 396595002607 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 396595002608 catalytic core [active] 396595002609 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 396595002610 putative active site [active] 396595002611 catalytic site [active] 396595002612 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 396595002613 putative active site [active] 396595002614 catalytic site [active] 396595002615 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 396595002616 nucleoside/Zn binding site; other site 396595002617 dimer interface [polypeptide binding]; other site 396595002618 catalytic motif [active] 396595002619 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 396595002620 active site 396595002621 ATP binding site [chemical binding]; other site 396595002622 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 396595002623 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 396595002624 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 396595002625 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 396595002626 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 396595002627 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 396595002628 active site 396595002629 dimer interface [polypeptide binding]; other site 396595002630 motif 1; other site 396595002631 motif 2; other site 396595002632 motif 3; other site 396595002633 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 396595002634 anticodon binding site; other site 396595002635 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 396595002636 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 396595002637 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 396595002638 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 396595002639 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 396595002640 23S rRNA binding site [nucleotide binding]; other site 396595002641 L21 binding site [polypeptide binding]; other site 396595002642 L13 binding site [polypeptide binding]; other site 396595002643 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 396595002644 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 396595002645 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 396595002646 dimer interface [polypeptide binding]; other site 396595002647 motif 1; other site 396595002648 active site 396595002649 motif 2; other site 396595002650 motif 3; other site 396595002651 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 396595002652 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 396595002653 putative tRNA-binding site [nucleotide binding]; other site 396595002654 B3/4 domain; Region: B3_4; cl11458 396595002655 tRNA synthetase B5 domain; Region: B5; cl08394 396595002656 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 396595002657 dimer interface [polypeptide binding]; other site 396595002658 motif 1; other site 396595002659 motif 3; other site 396595002660 motif 2; other site 396595002661 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 396595002662 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 396595002663 IHF dimer interface [polypeptide binding]; other site 396595002664 IHF - DNA interface [nucleotide binding]; other site 396595002665 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 396595002666 DNA binding residues [nucleotide binding] 396595002667 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 396595002668 FlgN protein; Region: FlgN; cl09176 396595002669 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 396595002670 SAF domain; Region: SAF; cl00555 396595002671 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 396595002672 Response regulator receiver domain; Region: Response_reg; pfam00072 396595002673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595002674 active site 396595002675 phosphorylation site [posttranslational modification] 396595002676 intermolecular recognition site; other site 396595002677 dimerization interface [polypeptide binding]; other site 396595002678 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 396595002679 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 396595002680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595002681 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 396595002682 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 396595002683 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 396595002684 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 396595002685 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 396595002686 Flagellar hook capping protein; Region: FlgD; cl04347 396595002687 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 396595002688 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 396595002689 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 396595002690 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 396595002691 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 396595002692 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 396595002693 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 396595002694 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 396595002695 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 396595002696 Flagellar L-ring protein; Region: FlgH; cl00905 396595002697 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 396595002698 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 396595002699 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 396595002700 Rod binding protein; Region: Rod-binding; cl01626 396595002701 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 396595002702 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 396595002703 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 396595002704 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 396595002705 Protein of unknown function (DUF541); Region: SIMPL; cl01077 396595002706 TIGR03440 family protein; Region: unchr_TIGR03440 396595002707 DinB superfamily; Region: DinB_2; cl00986 396595002708 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 396595002709 TIGR03442 family protein; Region: TIGR03442 396595002710 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 396595002711 putative active site [active] 396595002712 putative dimer interface [polypeptide binding]; other site 396595002713 probable methyltransferase; Region: TIGR03438 396595002714 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 396595002715 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 396595002716 catalytic core [active] 396595002717 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 396595002718 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 396595002719 polyphosphate kinase; Provisional; Region: PRK05443 396595002720 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 396595002721 putative domain interface [polypeptide binding]; other site 396595002722 putative active site [active] 396595002723 catalytic site [active] 396595002724 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 396595002725 putative domain interface [polypeptide binding]; other site 396595002726 putative active site [active] 396595002727 catalytic site [active] 396595002728 ornithine carbamoyltransferase; Provisional; Region: PRK00779 396595002729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 396595002730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595002731 acetylornithine aminotransferase; Provisional; Region: PRK02627 396595002732 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 396595002733 inhibitor-cofactor binding pocket; inhibition site 396595002734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595002735 catalytic residue [active] 396595002736 superoxide dismutase; Provisional; Region: PRK10543 396595002737 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 396595002738 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 396595002739 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 396595002740 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 396595002741 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 396595002742 dimerization interface [polypeptide binding]; other site 396595002743 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 396595002744 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 396595002745 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 396595002746 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 396595002747 DsrE/DsrF-like family; Region: DrsE; cl00672 396595002748 transcriptional regulator PhoU; Provisional; Region: PRK11115 396595002749 PhoU domain; Region: PhoU; pfam01895 396595002750 PhoU domain; Region: PhoU; pfam01895 396595002751 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 396595002752 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 396595002753 Walker A/P-loop; other site 396595002754 ATP binding site [chemical binding]; other site 396595002755 Q-loop/lid; other site 396595002756 ABC transporter signature motif; other site 396595002757 Walker B; other site 396595002758 D-loop; other site 396595002759 H-loop/switch region; other site 396595002760 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 396595002761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 396595002762 dimer interface [polypeptide binding]; other site 396595002763 conserved gate region; other site 396595002764 putative PBP binding loops; other site 396595002765 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 396595002766 ABC-ATPase subunit interface; other site 396595002767 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 396595002768 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 396595002769 structural tetrad; other site 396595002770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 396595002771 dimer interface [polypeptide binding]; other site 396595002772 conserved gate region; other site 396595002773 putative PBP binding loops; other site 396595002774 ABC-ATPase subunit interface; other site 396595002775 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 396595002776 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 396595002777 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 396595002778 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 396595002779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 396595002780 dimer interface [polypeptide binding]; other site 396595002781 phosphorylation site [posttranslational modification] 396595002782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595002783 ATP binding site [chemical binding]; other site 396595002784 Mg2+ binding site [ion binding]; other site 396595002785 G-X-G motif; other site 396595002786 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 396595002787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595002788 active site 396595002789 phosphorylation site [posttranslational modification] 396595002790 intermolecular recognition site; other site 396595002791 dimerization interface [polypeptide binding]; other site 396595002792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 396595002793 DNA binding site [nucleotide binding] 396595002794 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 396595002795 cyanate hydratase; Validated; Region: PRK02866 396595002796 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 396595002797 oligomer interface [polypeptide binding]; other site 396595002798 active site 396595002799 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 396595002800 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 396595002801 Walker A/P-loop; other site 396595002802 ATP binding site [chemical binding]; other site 396595002803 Q-loop/lid; other site 396595002804 ABC transporter signature motif; other site 396595002805 Walker B; other site 396595002806 D-loop; other site 396595002807 H-loop/switch region; other site 396595002808 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 396595002809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 396595002810 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 396595002811 Nif-specific regulatory protein; Region: nifA; TIGR01817 396595002812 GAF domain; Region: GAF; cl00853 396595002813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595002814 Walker A motif; other site 396595002815 ATP binding site [chemical binding]; other site 396595002816 Walker B motif; other site 396595002817 arginine finger; other site 396595002818 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 396595002819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 396595002820 dimer interface [polypeptide binding]; other site 396595002821 conserved gate region; other site 396595002822 putative PBP binding loops; other site 396595002823 ABC-ATPase subunit interface; other site 396595002824 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 396595002825 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 396595002826 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 396595002827 Walker A/P-loop; other site 396595002828 ATP binding site [chemical binding]; other site 396595002829 Q-loop/lid; other site 396595002830 ABC transporter signature motif; other site 396595002831 Walker B; other site 396595002832 D-loop; other site 396595002833 H-loop/switch region; other site 396595002834 OsmC-like protein; Region: OsmC; cl00767 396595002835 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 396595002836 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 396595002837 active site 396595002838 Domain of unknown function DUF302; Region: DUF302; cl01364 396595002839 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 396595002840 Rubredoxin; Region: Rubredoxin; pfam00301 396595002841 iron binding site [ion binding]; other site 396595002842 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 396595002843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595002844 Protein of unknown function (DUF2007); Region: DUF2007; pfam09413 396595002845 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 396595002846 N-acetyl-D-glucosamine binding site [chemical binding]; other site 396595002847 catalytic residue [active] 396595002848 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 396595002849 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 396595002850 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 396595002851 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 396595002852 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 396595002853 Sulfatase; Region: Sulfatase; cl10460 396595002854 Transposase, Mutator family; Region: Transposase_mut; pfam00872 396595002855 MULE transposase domain; Region: MULE; pfam10551 396595002856 peptide chain release factor 2; Validated; Region: prfB; PRK00578 396595002857 RF-1 domain; Region: RF-1; cl02875 396595002858 RF-1 domain; Region: RF-1; cl02875 396595002859 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 396595002860 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 396595002861 dimer interface [polypeptide binding]; other site 396595002862 putative anticodon binding site; other site 396595002863 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 396595002864 motif 1; other site 396595002865 active site 396595002866 motif 2; other site 396595002867 motif 3; other site 396595002868 high affinity sulphate transporter 1; Region: sulP; TIGR00815 396595002869 Sulfate transporter family; Region: Sulfate_transp; cl00967 396595002870 chromosome segregation protein; Provisional; Region: PRK02224 396595002871 Sulfate transporter family; Region: Sulfate_transp; cl00967 396595002872 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 396595002873 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 396595002874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 396595002875 dimer interface [polypeptide binding]; other site 396595002876 phosphorylation site [posttranslational modification] 396595002877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595002878 ATP binding site [chemical binding]; other site 396595002879 Mg2+ binding site [ion binding]; other site 396595002880 G-X-G motif; other site 396595002881 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 396595002882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595002883 active site 396595002884 phosphorylation site [posttranslational modification] 396595002885 intermolecular recognition site; other site 396595002886 dimerization interface [polypeptide binding]; other site 396595002887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595002888 Walker A motif; other site 396595002889 ATP binding site [chemical binding]; other site 396595002890 Walker B motif; other site 396595002891 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 396595002892 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 396595002893 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 396595002894 Domain of unknown function (DUF336); Region: DUF336; cl01249 396595002895 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 396595002896 Protein of unknown function (DUF418); Region: DUF418; cl12135 396595002897 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 396595002898 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 396595002899 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 396595002900 dimer interface [polypeptide binding]; other site 396595002901 Citrate synthase; Region: Citrate_synt; pfam00285 396595002902 active site 396595002903 citrylCoA binding site [chemical binding]; other site 396595002904 NADH binding [chemical binding]; other site 396595002905 cationic pore residues; other site 396595002906 oxalacetate/citrate binding site [chemical binding]; other site 396595002907 coenzyme A binding site [chemical binding]; other site 396595002908 catalytic triad [active] 396595002909 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595002910 metal binding site [ion binding]; metal-binding site 396595002911 active site 396595002912 I-site; other site 396595002913 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 396595002914 FAD binding domain; Region: FAD_binding_4; pfam01565 396595002915 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 396595002916 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 396595002917 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 396595002918 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 396595002919 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 396595002920 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 396595002921 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 396595002922 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 396595002923 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 396595002924 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 396595002925 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 396595002926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 396595002927 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 396595002928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595002929 NAD(P) binding site [chemical binding]; other site 396595002930 active site 396595002931 FAD binding domain; Region: FAD_binding_4; pfam01565 396595002932 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 396595002933 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 396595002934 UbiA prenyltransferase family; Region: UbiA; cl00337 396595002935 Predicted membrane protein [Function unknown]; Region: COG3671 396595002936 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 396595002937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595002938 Walker A motif; other site 396595002939 ATP binding site [chemical binding]; other site 396595002940 Walker B motif; other site 396595002941 arginine finger; other site 396595002942 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 396595002943 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 396595002944 putative active site [active] 396595002945 Ferredoxin [Energy production and conversion]; Region: COG1146 396595002946 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 396595002947 Hef nuclease; Provisional; Region: PRK13766 396595002948 ERCC4 domain; Region: ERCC4; cl10594 396595002949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595002950 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 396595002951 sensory histidine kinase AtoS; Provisional; Region: PRK11360 396595002952 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 396595002953 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595002954 metal binding site [ion binding]; metal-binding site 396595002955 active site 396595002956 I-site; other site 396595002957 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595002958 PAS domain S-box; Region: sensory_box; TIGR00229 396595002959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595002960 putative active site [active] 396595002961 heme pocket [chemical binding]; other site 396595002962 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595002963 metal binding site [ion binding]; metal-binding site 396595002964 active site 396595002965 I-site; other site 396595002966 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595002967 helicase 45; Provisional; Region: PTZ00424 396595002968 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 396595002969 ATP binding site [chemical binding]; other site 396595002970 Mg++ binding site [ion binding]; other site 396595002971 motif III; other site 396595002972 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 396595002973 nucleotide binding region [chemical binding]; other site 396595002974 ATP-binding site [chemical binding]; other site 396595002975 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 396595002976 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 396595002977 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 396595002978 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 396595002979 putative catalytic residues [active] 396595002980 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 396595002981 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350 396595002982 trimer interface [polypeptide binding]; other site 396595002983 active site 396595002984 substrate binding site [chemical binding]; other site 396595002985 CoA binding site [chemical binding]; other site 396595002986 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 396595002987 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 396595002988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595002989 homodimer interface [polypeptide binding]; other site 396595002990 catalytic residue [active] 396595002991 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 396595002992 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 396595002993 active site residue [active] 396595002994 N-formylglutamate amidohydrolase; Region: FGase; cl01522 396595002995 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 396595002996 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 396595002997 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 396595002998 active site 396595002999 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 396595003000 active site residue [active] 396595003001 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 396595003002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595003003 S-adenosylmethionine binding site [chemical binding]; other site 396595003004 HAD-superfamily subfamily IIA hydrolase, TIGR01458; Region: HAD-SF-IIA-hyp3 396595003005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 396595003006 active site 396595003007 motif I; other site 396595003008 motif II; other site 396595003009 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 396595003010 DEAD-like helicases superfamily; Region: DEXDc; smart00487 396595003011 ATP binding site [chemical binding]; other site 396595003012 Mg++ binding site [ion binding]; other site 396595003013 motif III; other site 396595003014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 396595003015 nucleotide binding region [chemical binding]; other site 396595003016 ATP-binding site [chemical binding]; other site 396595003017 DbpA RNA binding domain; Region: DbpA; pfam03880 396595003018 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 396595003019 dimer interface [polypeptide binding]; other site 396595003020 active site 396595003021 metal binding site [ion binding]; metal-binding site 396595003022 glutathione binding site [chemical binding]; other site 396595003023 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 396595003024 Transposase; Region: DEDD_Tnp_IS110; pfam01548 396595003025 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 396595003026 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 396595003027 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 396595003028 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 396595003029 synthetase active site [active] 396595003030 NTP binding site [chemical binding]; other site 396595003031 metal binding site [ion binding]; metal-binding site 396595003032 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 396595003033 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 396595003034 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 396595003035 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 396595003036 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 396595003037 homotrimer interaction site [polypeptide binding]; other site 396595003038 putative active site [active] 396595003039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595003040 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 396595003041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595003042 S-adenosylmethionine binding site [chemical binding]; other site 396595003043 Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811 396595003044 Dihydroorotase [Nucleotide transport and metabolism]; Region: PyrC; COG0418 396595003045 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 396595003046 active site 396595003047 substrate binding pocket [chemical binding]; other site 396595003048 dimer interface [polypeptide binding]; other site 396595003049 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 396595003050 putative ADP-ribose binding site [chemical binding]; other site 396595003051 putative active site [active] 396595003052 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 396595003053 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 396595003054 Protein of unknown function (DUF432); Region: DUF432; cl01027 396595003055 Mechanosensitive ion channel; Region: MS_channel; pfam00924 396595003056 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 396595003057 generic binding surface II; other site 396595003058 generic binding surface I; other site 396595003059 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 396595003060 putative active site [active] 396595003061 putative catalytic site [active] 396595003062 putative Mg binding site IVb [ion binding]; other site 396595003063 putative phosphate binding site [ion binding]; other site 396595003064 putative DNA binding site [nucleotide binding]; other site 396595003065 putative Mg binding site IVa [ion binding]; other site 396595003066 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595003067 Rrf2 family protein; Region: rrf2_super; TIGR00738 396595003068 Bacitracin resistance protein BacA; Region: BacA; cl00858 396595003069 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 396595003070 FtsX-like permease family; Region: FtsX; pfam02687 396595003071 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 396595003072 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 396595003073 Walker A/P-loop; other site 396595003074 ATP binding site [chemical binding]; other site 396595003075 Q-loop/lid; other site 396595003076 ABC transporter signature motif; other site 396595003077 Walker B; other site 396595003078 D-loop; other site 396595003079 H-loop/switch region; other site 396595003080 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 396595003081 active site 396595003082 catalytic triad [active] 396595003083 oxyanion hole [active] 396595003084 switch loop; other site 396595003085 HPP family; Region: HPP; pfam04982 396595003086 flagellar motor protein MotD; Reviewed; Region: PRK09038 396595003087 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 396595003088 ligand binding site [chemical binding]; other site 396595003089 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 396595003090 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 396595003091 LemA family; Region: LemA; cl00742 396595003092 Peptidase family M48; Region: Peptidase_M48; cl12018 396595003093 CHASE domain; Region: CHASE; cl01369 396595003094 PAS fold; Region: PAS; pfam00989 396595003095 PAS fold; Region: PAS_4; pfam08448 396595003096 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595003097 metal binding site [ion binding]; metal-binding site 396595003098 active site 396595003099 I-site; other site 396595003100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595003101 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 396595003102 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 396595003103 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 396595003104 putative peptidase; Provisional; Region: PRK11649 396595003105 Peptidase family M23; Region: Peptidase_M23; pfam01551 396595003106 ABC-2 type transporter; Region: ABC2_membrane; cl11417 396595003107 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 396595003108 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595003109 Walker A/P-loop; other site 396595003110 ATP binding site [chemical binding]; other site 396595003111 Q-loop/lid; other site 396595003112 ABC transporter signature motif; other site 396595003113 Walker B; other site 396595003114 D-loop; other site 396595003115 H-loop/switch region; other site 396595003116 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 396595003117 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 396595003118 interface (dimer of trimers) [polypeptide binding]; other site 396595003119 Substrate-binding/catalytic site; other site 396595003120 Zn-binding sites [ion binding]; other site 396595003121 Creatinine amidohydrolase; Region: Creatininase; cl00618 396595003122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595003123 Protein of unknown function, DUF399; Region: DUF399; cl01139 396595003124 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 396595003125 protein binding site [polypeptide binding]; other site 396595003126 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 396595003127 Zn binding site [ion binding]; other site 396595003128 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 396595003129 Surface antigen; Region: Surface_Ag_2; cl01155 396595003130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595003131 short chain dehydrogenase; Provisional; Region: PRK06924 396595003132 NAD(P) binding site [chemical binding]; other site 396595003133 active site 396595003134 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 396595003135 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 396595003136 FOG: CBS domain [General function prediction only]; Region: COG0517 396595003137 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_17; cd04630 396595003138 PAS domain S-box; Region: sensory_box; TIGR00229 396595003139 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595003140 putative active site [active] 396595003141 heme pocket [chemical binding]; other site 396595003142 PAS domain S-box; Region: sensory_box; TIGR00229 396595003143 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595003144 putative active site [active] 396595003145 heme pocket [chemical binding]; other site 396595003146 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595003147 metal binding site [ion binding]; metal-binding site 396595003148 active site 396595003149 I-site; other site 396595003150 phosphomannomutase CpsG; Provisional; Region: PRK15414 396595003151 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 396595003152 active site 396595003153 substrate binding site [chemical binding]; other site 396595003154 metal binding site [ion binding]; metal-binding site 396595003155 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 396595003156 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 396595003157 Substrate binding site [chemical binding]; other site 396595003158 Cupin domain; Region: Cupin_2; cl09118 396595003159 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 396595003160 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 396595003161 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 396595003162 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 396595003163 generic binding surface II; other site 396595003164 generic binding surface I; other site 396595003165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595003166 S-adenosylmethionine binding site [chemical binding]; other site 396595003167 putative transposase OrfB; Reviewed; Region: PHA02517 396595003168 Integrase core domain; Region: rve; cl01316 396595003169 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 396595003170 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595003171 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 396595003172 Phage integrase family; Region: Phage_integrase; pfam00589 396595003173 DNA binding site [nucleotide binding] 396595003174 Int/Topo IB signature motif; other site 396595003175 active site 396595003176 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 396595003177 active site 396595003178 NTP binding site [chemical binding]; other site 396595003179 metal binding triad [ion binding]; metal-binding site 396595003180 antibiotic binding site [chemical binding]; other site 396595003181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 396595003182 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 396595003183 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 396595003184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 396595003185 Transposase domain (DUF772); Region: DUF772; cl12084 396595003186 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 396595003187 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 396595003188 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 396595003189 Surface antigen; Region: Surface_Ag_2; cl01155 396595003190 PAS fold; Region: PAS_4; pfam08448 396595003191 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595003192 metal binding site [ion binding]; metal-binding site 396595003193 active site 396595003194 I-site; other site 396595003195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595003196 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 396595003197 Walker A motif; other site 396595003198 ATP binding site [chemical binding]; other site 396595003199 Walker B motif; other site 396595003200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595003201 Walker A motif; other site 396595003202 ATP binding site [chemical binding]; other site 396595003203 Walker B motif; other site 396595003204 arginine finger; other site 396595003205 Predicted transcriptional regulator [Transcription]; Region: COG2378 396595003206 Transposase, Mutator family; Region: Transposase_mut; pfam00872 396595003207 MULE transposase domain; Region: MULE; pfam10551 396595003208 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 396595003209 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 396595003210 putative active site [active] 396595003211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595003212 PglZ domain; Region: PglZ; pfam08665 396595003213 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 396595003214 putative ATP-dependent protease; Region: PHA01747; cl11979 396595003215 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 396595003216 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 396595003217 Integrase core domain; Region: rve; cl01316 396595003218 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 396595003219 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 396595003220 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 396595003221 Phage integrase family; Region: Phage_integrase; pfam00589 396595003222 DNA binding site [nucleotide binding] 396595003223 Int/Topo IB signature motif; other site 396595003224 active site 396595003225 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 396595003226 putative active site [active] 396595003227 catalytic site [active] 396595003228 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 396595003229 putative active site [active] 396595003230 catalytic site [active] 396595003231 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 396595003232 Double zinc ribbon; Region: DZR; pfam12773 396595003233 RDD family; Region: RDD; cl00746 396595003234 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 396595003235 active site 396595003236 intersubunit interface [polypeptide binding]; other site 396595003237 catalytic residue [active] 396595003238 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 396595003239 active site 396595003240 metal binding site [ion binding]; metal-binding site 396595003241 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 396595003242 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 396595003243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595003244 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 396595003245 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 396595003246 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 396595003247 dimerization interface [polypeptide binding]; other site 396595003248 ATP binding site [chemical binding]; other site 396595003249 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 396595003250 dimerization interface [polypeptide binding]; other site 396595003251 ATP binding site [chemical binding]; other site 396595003252 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 396595003253 putative active site [active] 396595003254 catalytic triad [active] 396595003255 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 396595003256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595003257 Walker A motif; other site 396595003258 ATP binding site [chemical binding]; other site 396595003259 Walker B motif; other site 396595003260 arginine finger; other site 396595003261 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 396595003262 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 396595003263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595003264 Walker A motif; other site 396595003265 ATP binding site [chemical binding]; other site 396595003266 Walker B motif; other site 396595003267 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 396595003268 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 396595003269 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 396595003270 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 396595003271 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 396595003272 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 396595003273 MgtE intracellular N domain; Region: MgtE_N; cl15244 396595003274 FliG C-terminal domain; Region: FliG_C; pfam01706 396595003275 Flagellar assembly protein FliH; Region: FliH; pfam02108 396595003276 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 396595003277 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 396595003278 Walker A motif/ATP binding site; other site 396595003279 Walker B motif; other site 396595003280 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 396595003281 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 396595003282 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 396595003283 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 396595003284 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 396595003285 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 396595003286 FliP family; Region: FliP; cl00593 396595003287 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 396595003288 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 396595003289 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 396595003290 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 396595003291 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 396595003292 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 396595003293 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 396595003294 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 396595003295 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 396595003296 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 396595003297 P-loop; other site 396595003298 ADP binding residues [chemical binding]; other site 396595003299 Switch I; other site 396595003300 Switch II; other site 396595003301 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 396595003302 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 396595003303 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 396595003304 DNA binding residues [nucleotide binding] 396595003305 Response regulator receiver domain; Region: Response_reg; pfam00072 396595003306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595003307 active site 396595003308 phosphorylation site [posttranslational modification] 396595003309 intermolecular recognition site; other site 396595003310 dimerization interface [polypeptide binding]; other site 396595003311 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 396595003312 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 396595003313 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 396595003314 putative binding surface; other site 396595003315 active site 396595003316 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 396595003317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595003318 ATP binding site [chemical binding]; other site 396595003319 Mg2+ binding site [ion binding]; other site 396595003320 G-X-G motif; other site 396595003321 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 396595003322 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 396595003323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595003324 active site 396595003325 phosphorylation site [posttranslational modification] 396595003326 intermolecular recognition site; other site 396595003327 dimerization interface [polypeptide binding]; other site 396595003328 CheB methylesterase; Region: CheB_methylest; pfam01339 396595003329 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 396595003330 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 396595003331 flagellar motor protein MotD; Reviewed; Region: PRK09038 396595003332 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 396595003333 ligand binding site [chemical binding]; other site 396595003334 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 396595003335 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 396595003336 Magnesium ion binding site [ion binding]; other site 396595003337 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 396595003338 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 396595003339 putative CheA interaction surface; other site 396595003340 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 396595003341 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 396595003342 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 396595003343 Low molecular weight phosphatase family; Region: LMWPc; cd00115 396595003344 Active site [active] 396595003345 ribonuclease E; Reviewed; Region: rne; PRK10811 396595003346 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 396595003347 homodimer interface [polypeptide binding]; other site 396595003348 oligonucleotide binding site [chemical binding]; other site 396595003349 transcriptional regulator ICP4; Provisional; Region: PHA03307 396595003350 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 396595003351 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 396595003352 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 396595003353 active site 396595003354 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 396595003355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 396595003356 motif II; other site 396595003357 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 396595003358 tandem repeat interface [polypeptide binding]; other site 396595003359 oligomer interface [polypeptide binding]; other site 396595003360 active site residues [active] 396595003361 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 396595003362 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 396595003363 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 396595003364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 396595003365 ATP binding site [chemical binding]; other site 396595003366 putative Mg++ binding site [ion binding]; other site 396595003367 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 396595003368 nucleotide binding region [chemical binding]; other site 396595003369 ATP-binding site [chemical binding]; other site 396595003370 TRCF domain; Region: TRCF; cl04088 396595003371 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 396595003372 putative active site; other site 396595003373 catalytic triad [active] 396595003374 putative dimer interface [polypeptide binding]; other site 396595003375 agmatine deiminase; Region: agmatine_aguA; TIGR03380 396595003376 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 396595003377 LolC/E family; Region: lolCE; TIGR02212 396595003378 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 396595003379 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 396595003380 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 396595003381 Walker A/P-loop; other site 396595003382 ATP binding site [chemical binding]; other site 396595003383 Q-loop/lid; other site 396595003384 ABC transporter signature motif; other site 396595003385 Walker B; other site 396595003386 D-loop; other site 396595003387 H-loop/switch region; other site 396595003388 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 396595003389 Competence protein; Region: Competence; cl00471 396595003390 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 396595003391 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 396595003392 Initiation factor 2 subunit family; Region: IF-2B; pfam01008 396595003393 DNA gyrase subunit A; Validated; Region: PRK05560 396595003394 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 396595003395 CAP-like domain; other site 396595003396 Active site [active] 396595003397 primary dimer interface [polypeptide binding]; other site 396595003398 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 396595003399 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 396595003400 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 396595003401 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 396595003402 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active...; Region: PSAT_like; cd00611 396595003403 homodimer interface [polypeptide binding]; other site 396595003404 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 396595003405 substrate-cofactor binding pocket; other site 396595003406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595003407 catalytic residue [active] 396595003408 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 396595003409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595003410 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 396595003411 L-serine binding site [chemical binding]; other site 396595003412 ACT domain interface; other site 396595003413 Chorismate mutase type II; Region: CM_2; cl00693 396595003414 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 396595003415 Prephenate dehydratase; Region: PDT; pfam00800 396595003416 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 396595003417 putative L-Phe binding site [chemical binding]; other site 396595003418 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 396595003419 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 396595003420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595003421 homodimer interface [polypeptide binding]; other site 396595003422 catalytic residue [active] 396595003423 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 396595003424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595003425 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 396595003426 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 396595003427 hinge; other site 396595003428 active site 396595003429 cytidylate kinase; Provisional; Region: cmk; PRK00023 396595003430 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 396595003431 CMP-binding site; other site 396595003432 The sites determining sugar specificity; other site 396595003433 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 396595003434 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 396595003435 RNA binding site [nucleotide binding]; other site 396595003436 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 396595003437 RNA binding site [nucleotide binding]; other site 396595003438 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 396595003439 RNA binding site [nucleotide binding]; other site 396595003440 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 396595003441 RNA binding site [nucleotide binding]; other site 396595003442 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 396595003443 RNA binding site [nucleotide binding]; other site 396595003444 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 396595003445 RNA binding site [nucleotide binding]; other site 396595003446 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 396595003447 IHF dimer interface [polypeptide binding]; other site 396595003448 IHF - DNA interface [nucleotide binding]; other site 396595003449 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 396595003450 tetratricopeptide repeat protein; Provisional; Region: PRK11788 396595003451 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 396595003452 active site 396595003453 dimer interface [polypeptide binding]; other site 396595003454 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 396595003455 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 396595003456 active site 396595003457 tetramer interface [polypeptide binding]; other site 396595003458 Rhomboid family; Region: Rhomboid; cl11446 396595003459 Dehydratase family; Region: ILVD_EDD; cl00340 396595003460 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 396595003461 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 396595003462 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 396595003463 nudix motif; other site 396595003464 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 396595003465 intersubunit interface [polypeptide binding]; other site 396595003466 active site 396595003467 Zn2+ binding site [ion binding]; other site 396595003468 Cytochrome C'; Region: Cytochrom_C_2; cl01610 396595003469 Cytochrome c; Region: Cytochrom_C; cl11414 396595003470 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 396595003471 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 396595003472 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 396595003473 DNA binding site [nucleotide binding] 396595003474 Int/Topo IB signature motif; other site 396595003475 active site 396595003476 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 396595003477 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 396595003478 replicative DNA helicase; Region: DnaB; TIGR00665 396595003479 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 396595003480 Walker A motif; other site 396595003481 ATP binding site [chemical binding]; other site 396595003482 Walker B motif; other site 396595003483 DNA binding loops [nucleotide binding] 396595003484 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 396595003485 hypothetical protein; Validated; Region: PRK07682 396595003486 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 396595003487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595003488 homodimer interface [polypeptide binding]; other site 396595003489 catalytic residue [active] 396595003490 excinuclease ABC subunit B; Provisional; Region: PRK05298 396595003491 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 396595003492 ATP binding site [chemical binding]; other site 396595003493 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 396595003494 nucleotide binding region [chemical binding]; other site 396595003495 ATP-binding site [chemical binding]; other site 396595003496 Ultra-violet resistance protein B; Region: UvrB; pfam12344 396595003497 UvrB/uvrC motif; Region: UVR; pfam02151 396595003498 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 396595003499 DsrE/DsrF-like family; Region: DrsE; cl00672 396595003500 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 396595003501 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 396595003502 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 396595003503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 396595003504 DNA binding residues [nucleotide binding] 396595003505 dimerization interface [polypeptide binding]; other site 396595003506 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 396595003507 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 396595003508 inhibitor-cofactor binding pocket; inhibition site 396595003509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595003510 catalytic residue [active] 396595003511 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 396595003512 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 396595003513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 396595003514 catalytic residue [active] 396595003515 PilZ domain; Region: PilZ; cl01260 396595003516 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 396595003517 thymidylate kinase; Validated; Region: tmk; PRK00698 396595003518 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 396595003519 TMP-binding site; other site 396595003520 ATP-binding site [chemical binding]; other site 396595003521 YceG-like family; Region: YceG; pfam02618 396595003522 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 396595003523 dimerization interface [polypeptide binding]; other site 396595003524 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 396595003525 Aminotransferase class IV; Region: Aminotran_4; pfam01063 396595003526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595003527 catalytic residue [active] 396595003528 hypothetical protein; Validated; Region: PRK09070 396595003529 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 396595003530 chorismate binding enzyme; Region: Chorismate_bind; cl10555 396595003531 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 396595003532 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 396595003533 dimer interface [polypeptide binding]; other site 396595003534 active site 396595003535 Phosphopantetheine attachment site; Region: PP-binding; cl09936 396595003536 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 396595003537 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 396595003538 NAD(P) binding site [chemical binding]; other site 396595003539 homotetramer interface [polypeptide binding]; other site 396595003540 homodimer interface [polypeptide binding]; other site 396595003541 active site 396595003542 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 396595003543 Acyl transferase domain; Region: Acyl_transf_1; cl08282 396595003544 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 396595003545 rRNA binding site [nucleotide binding]; other site 396595003546 predicted 30S ribosome binding site; other site 396595003547 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 396595003548 Clp amino terminal domain; Region: Clp_N; pfam02861 396595003549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595003550 Walker A motif; other site 396595003551 ATP binding site [chemical binding]; other site 396595003552 Walker B motif; other site 396595003553 arginine finger; other site 396595003554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595003555 Walker A motif; other site 396595003556 ATP binding site [chemical binding]; other site 396595003557 Walker B motif; other site 396595003558 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 396595003559 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 396595003560 isocitrate dehydrogenase; Validated; Region: PRK07362 396595003561 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 396595003562 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X...; Region: Nudix_Hydrolase_2; cd03675 396595003563 nudix motif; other site 396595003564 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 396595003565 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 396595003566 Ligand Binding Site [chemical binding]; other site 396595003567 Protein of unknown function (DUF489); Region: DUF489; cl01097 396595003568 aconitate hydratase; Validated; Region: PRK09277 396595003569 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 396595003570 substrate binding site [chemical binding]; other site 396595003571 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 396595003572 ligand binding site [chemical binding]; other site 396595003573 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 396595003574 substrate binding site [chemical binding]; other site 396595003575 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 396595003576 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 396595003577 conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319 396595003578 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595003579 metal binding site [ion binding]; metal-binding site 396595003580 active site 396595003581 I-site; other site 396595003582 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595003583 fumarate hydratase; Reviewed; Region: fumC; PRK00485 396595003584 Class II fumarases; Region: Fumarase_classII; cd01362 396595003585 active site 396595003586 tetramer interface [polypeptide binding]; other site 396595003587 adenylosuccinate lyase; Provisional; Region: PRK09285 396595003588 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 396595003589 tetramer interface [polypeptide binding]; other site 396595003590 active site 396595003591 Cupin superfamily protein; Region: Cupin_4; pfam08007 396595003592 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 396595003593 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 396595003594 FMN binding site [chemical binding]; other site 396595003595 active site 396595003596 catalytic residues [active] 396595003597 substrate binding site [chemical binding]; other site 396595003598 Transposase, Mutator family; Region: Transposase_mut; pfam00872 396595003599 MULE transposase domain; Region: MULE; pfam10551 396595003600 GTP cyclohydrolase; Provisional; Region: PRK08815 396595003601 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 396595003602 dimerization interface [polypeptide binding]; other site 396595003603 active site 396595003604 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 396595003605 threonine synthase; Reviewed; Region: PRK06721 396595003606 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 396595003607 homodimer interface [polypeptide binding]; other site 396595003608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595003609 catalytic residue [active] 396595003610 homoserine dehydrogenase; Provisional; Region: PRK06349 396595003611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595003612 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 396595003613 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 396595003614 aspartate aminotransferase; Provisional; Region: PRK07681 396595003615 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 396595003616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595003617 homodimer interface [polypeptide binding]; other site 396595003618 catalytic residue [active] 396595003619 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome...; Region: Xcc1710_like; cd05560 396595003620 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 396595003621 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 396595003622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 396595003623 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 396595003624 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 396595003625 DNA binding residues [nucleotide binding] 396595003626 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 396595003627 putative peptidoglycan binding site; other site 396595003628 Peptidase family M23; Region: Peptidase_M23; pfam01551 396595003629 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 396595003630 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 396595003631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595003632 S-adenosylmethionine binding site [chemical binding]; other site 396595003633 Survival protein SurE; Region: SurE; cl00448 396595003634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 396595003635 Smr domain; Region: Smr; cl02619 396595003636 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 396595003637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 396595003638 Transposase; Region: DDE_Tnp_ISL3; pfam01610 396595003639 PAS domain S-box; Region: sensory_box; TIGR00229 396595003640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595003641 putative active site [active] 396595003642 heme pocket [chemical binding]; other site 396595003643 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 396595003644 PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575 396595003645 Permutation of conserved domain; other site 396595003646 active site 396595003647 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 396595003648 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 396595003649 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595003650 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595003651 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595003652 TPR motif; other site 396595003653 binding surface 396595003654 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 396595003655 Transglycosylase; Region: Transgly; cl07896 396595003656 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 396595003657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 396595003658 Predicted kinase [General function prediction only]; Region: COG0645 396595003659 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 396595003660 ATP-binding site [chemical binding]; other site 396595003661 Gluconate-6-phosphate binding site [chemical binding]; other site 396595003662 NlpC/P60 family; Region: NLPC_P60; cl11438 396595003663 Domain of unknown function DUF302; Region: DUF302; cl01364 396595003664 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 396595003665 Protein export membrane protein; Region: SecD_SecF; cl14618 396595003666 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 396595003667 Protein export membrane protein; Region: SecD_SecF; cl14618 396595003668 Preprotein translocase subunit; Region: YajC; cl00806 396595003669 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 396595003670 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 396595003671 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 396595003672 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 396595003673 Outer membrane efflux protein; Region: OEP; pfam02321 396595003674 Outer membrane efflux protein; Region: OEP; pfam02321 396595003675 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 396595003676 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595003677 metal binding site [ion binding]; metal-binding site 396595003678 active site 396595003679 I-site; other site 396595003680 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595003681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 396595003682 type 1 secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 396595003683 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 396595003684 type 1 secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 396595003685 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 396595003686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 396595003687 DNA binding residues [nucleotide binding] 396595003688 dimerization interface [polypeptide binding]; other site 396595003689 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 396595003690 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 396595003691 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 396595003692 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 396595003693 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 396595003694 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 396595003695 Walker A/P-loop; other site 396595003696 ATP binding site [chemical binding]; other site 396595003697 Q-loop/lid; other site 396595003698 ABC transporter signature motif; other site 396595003699 Walker B; other site 396595003700 D-loop; other site 396595003701 H-loop/switch region; other site 396595003702 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 396595003703 nucleoside/Zn binding site; other site 396595003704 dimer interface [polypeptide binding]; other site 396595003705 catalytic motif [active] 396595003706 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 396595003707 catalytic residues [active] 396595003708 dimer interface [polypeptide binding]; other site 396595003709 Protein of unknown function (DUF330); Region: DUF330; cl01135 396595003710 Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094 396595003711 paraquat-inducible protein B; Provisional; Region: PRK10807 396595003712 mce related protein; Region: MCE; pfam02470 396595003713 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 396595003714 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 396595003715 Walker A/P-loop; other site 396595003716 ATP binding site [chemical binding]; other site 396595003717 Q-loop/lid; other site 396595003718 ABC transporter signature motif; other site 396595003719 Walker B; other site 396595003720 D-loop; other site 396595003721 H-loop/switch region; other site 396595003722 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 396595003723 anti sigma factor interaction site; other site 396595003724 regulatory phosphorylation site [posttranslational modification]; other site 396595003725 Domain of unknown function DUF140; Region: DUF140; cl00510 396595003726 MoxR-like ATPases [General function prediction only]; Region: COG0714 396595003727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595003728 Walker A motif; other site 396595003729 ATP binding site [chemical binding]; other site 396595003730 Walker B motif; other site 396595003731 arginine finger; other site 396595003732 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 396595003733 Protein of unknown function DUF58; Region: DUF58; pfam01882 396595003734 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 396595003735 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 396595003736 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 396595003737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595003738 Rrf2 family protein; Region: rrf2_super; TIGR00738 396595003739 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 396595003740 amidophosphoribosyltransferase; Provisional; Region: PRK09246 396595003741 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 396595003742 active site 396595003743 tetramer interface [polypeptide binding]; other site 396595003744 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 396595003745 Colicin V production protein; Region: Colicin_V; cl00567 396595003746 Sporulation related domain; Region: SPOR; cl10051 396595003747 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 396595003748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 396595003749 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 396595003750 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 396595003751 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 396595003752 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 396595003753 substrate binding site [chemical binding]; other site 396595003754 active site 396595003755 catalytic residues [active] 396595003756 heterodimer interface [polypeptide binding]; other site 396595003757 tryptophan synthase, beta chain; Region: PLN02618 396595003758 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 396595003759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595003760 catalytic residue [active] 396595003761 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 396595003762 active site 396595003763 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 396595003764 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 396595003765 dimerization interface 3.5A [polypeptide binding]; other site 396595003766 active site 396595003767 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 396595003768 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 396595003769 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 396595003770 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 396595003771 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 396595003772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595003773 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 396595003774 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 396595003775 isocitrate dehydrogenase; Validated; Region: PRK06451 396595003776 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 396595003777 substrate binding site [chemical binding]; other site 396595003778 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 396595003779 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 396595003780 substrate binding site [chemical binding]; other site 396595003781 ligand binding site [chemical binding]; other site 396595003782 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 396595003783 Integrase core domain; Region: rve; cl01316 396595003784 Transcriptional regulator [Transcription]; Region: LysR; COG0583 396595003785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595003786 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 396595003787 dimerization interface [polypeptide binding]; other site 396595003788 Major Facilitator Superfamily; Region: MFS_1; pfam07690 396595003789 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 396595003790 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 396595003791 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 396595003792 TspO/MBR family; Region: TspO_MBR; cl01379 396595003793 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 396595003794 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 396595003795 Protein export membrane protein; Region: SecD_SecF; cl14618 396595003796 Outer membrane efflux protein; Region: OEP; pfam02321 396595003797 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 396595003798 Outer membrane efflux protein; Region: OEP; pfam02321 396595003799 ABC-2 type transporter; Region: ABC2_membrane; cl11417 396595003800 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595003801 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 396595003802 Walker A/P-loop; other site 396595003803 ATP binding site [chemical binding]; other site 396595003804 Q-loop/lid; other site 396595003805 ABC transporter signature motif; other site 396595003806 Walker B; other site 396595003807 D-loop; other site 396595003808 H-loop/switch region; other site 396595003809 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 396595003810 putative deacylase active site [active] 396595003811 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595003812 metal binding site [ion binding]; metal-binding site 396595003813 active site 396595003814 I-site; other site 396595003815 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 396595003816 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 396595003817 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 396595003818 tryptophan synthase, beta chain; Region: PLN02618 396595003819 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 396595003820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595003821 catalytic residue [active] 396595003822 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 396595003823 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 396595003824 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 396595003825 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 396595003826 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 396595003827 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 396595003828 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 396595003829 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 396595003830 FAD binding pocket [chemical binding]; other site 396595003831 FAD binding motif [chemical binding]; other site 396595003832 phosphate binding motif [ion binding]; other site 396595003833 beta-alpha-beta structure motif; other site 396595003834 NAD binding pocket [chemical binding]; other site 396595003835 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 396595003836 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 396595003837 Catalytic domain of Protein Kinases; Region: PKc; cd00180 396595003838 active site 396595003839 ATP binding site [chemical binding]; other site 396595003840 substrate binding site [chemical binding]; other site 396595003841 activation loop (A-loop); other site 396595003842 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 396595003843 GAF domain; Region: GAF; cl00853 396595003844 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 396595003845 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 396595003846 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 396595003847 putative dimer interface [polypeptide binding]; other site 396595003848 Rhomboid family; Region: Rhomboid; cl11446 396595003849 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 396595003850 catalytic nucleophile [active] 396595003851 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 396595003852 active site 396595003853 purine riboside binding site [chemical binding]; other site 396595003854 amidase; Provisional; Region: PRK06529 396595003855 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 396595003856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595003857 active site 396595003858 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 396595003859 phosphorylation site [posttranslational modification] 396595003860 intermolecular recognition site; other site 396595003861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595003862 active site 396595003863 phosphorylation site [posttranslational modification] 396595003864 intermolecular recognition site; other site 396595003865 dimerization interface [polypeptide binding]; other site 396595003866 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595003867 metal binding site [ion binding]; metal-binding site 396595003868 active site 396595003869 I-site; other site 396595003870 Heme NO binding; Region: HNOB; cl15268 396595003871 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595003872 metal binding site [ion binding]; metal-binding site 396595003873 active site 396595003874 I-site; other site 396595003875 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595003876 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 396595003877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595003878 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 396595003879 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595003880 Walker A motif; other site 396595003881 ATP binding site [chemical binding]; other site 396595003882 Walker B motif; other site 396595003883 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 396595003884 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 396595003885 NADP binding site [chemical binding]; other site 396595003886 dimer interface [polypeptide binding]; other site 396595003887 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 396595003888 THUMP domain; Region: THUMP; cl12076 396595003889 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 396595003890 Ligand Binding Site [chemical binding]; other site 396595003891 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 396595003892 active site residue [active] 396595003893 Protein of unknown function (DUF523); Region: DUF523; cl00733 396595003894 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 396595003895 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 396595003896 nucleophile elbow; other site 396595003897 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 396595003898 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 396595003899 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 396595003900 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 396595003901 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595003902 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 396595003903 ligand binding site [chemical binding]; other site 396595003904 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595003905 metal binding site [ion binding]; metal-binding site 396595003906 active site 396595003907 I-site; other site 396595003908 Transposase, Mutator family; Region: Transposase_mut; pfam00872 396595003909 MULE transposase domain; Region: MULE; pfam10551 396595003910 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 396595003911 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 396595003912 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 396595003913 ligand binding site [chemical binding]; other site 396595003914 flexible hinge region; other site 396595003915 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595003916 CsbD-like; Region: CsbD; cl01272 396595003917 putative transposase OrfB; Reviewed; Region: PHA02517 396595003918 Integrase core domain; Region: rve; cl01316 396595003919 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 396595003920 L-lactate permease; Region: Lactate_perm; cl00701 396595003921 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 396595003922 flagellin; Reviewed; Region: PRK08869 396595003923 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 396595003924 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 396595003925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595003926 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 396595003927 putative active site [active] 396595003928 heme pocket [chemical binding]; other site 396595003929 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595003930 putative active site [active] 396595003931 heme pocket [chemical binding]; other site 396595003932 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 396595003933 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595003934 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 396595003935 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 396595003936 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 396595003937 substrate binding pocket [chemical binding]; other site 396595003938 membrane-bound complex binding site; other site 396595003939 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 396595003940 UbiA prenyltransferase family; Region: UbiA; cl00337 396595003941 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 396595003942 hydrophobic ligand binding site; other site 396595003943 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 396595003944 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 396595003945 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 396595003946 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 396595003947 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 396595003948 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 396595003949 dimer interface [polypeptide binding]; other site 396595003950 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 396595003951 active site 396595003952 metal binding site [ion binding]; metal-binding site 396595003953 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 396595003954 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 396595003955 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 396595003956 nucleotide binding site/active site [active] 396595003957 HIT family signature motif; other site 396595003958 catalytic residue [active] 396595003959 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 396595003960 Cytochrome c; Region: Cytochrom_C; cl11414 396595003961 Cytochrome c; Region: Cytochrom_C; cl11414 396595003962 PAS domain S-box; Region: sensory_box; TIGR00229 396595003963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595003964 putative active site [active] 396595003965 heme pocket [chemical binding]; other site 396595003966 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 396595003967 GAF domain; Region: GAF; cl00853 396595003968 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595003969 metal binding site [ion binding]; metal-binding site 396595003970 active site 396595003971 I-site; other site 396595003972 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595003973 metal binding site [ion binding]; metal-binding site 396595003974 active site 396595003975 I-site; other site 396595003976 Major Facilitator Superfamily; Region: MFS_1; pfam07690 396595003977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 396595003978 putative substrate translocation pore; other site 396595003979 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 396595003980 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 396595003981 active site 396595003982 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 396595003983 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 396595003984 Protein of unknown function (DUF3532); Region: DUF3532; pfam12050 396595003985 Transposase, Mutator family; Region: Transposase_mut; pfam00872 396595003986 MULE transposase domain; Region: MULE; pfam10551 396595003987 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 396595003988 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 396595003989 putative active site [active] 396595003990 putative NTP binding site [chemical binding]; other site 396595003991 putative nucleic acid binding site [nucleotide binding]; other site 396595003992 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 396595003993 dimer interface [polypeptide binding]; other site 396595003994 putative radical transfer pathway; other site 396595003995 diiron center [ion binding]; other site 396595003996 tyrosyl radical; other site 396595003997 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 396595003998 ATP cone domain; Region: ATP-cone; pfam03477 396595003999 ATP cone domain; Region: ATP-cone; pfam03477 396595004000 Class I ribonucleotide reductase; Region: RNR_I; cd01679 396595004001 active site 396595004002 dimer interface [polypeptide binding]; other site 396595004003 catalytic residues [active] 396595004004 effector binding site; other site 396595004005 R2 peptide binding site; other site 396595004006 thioredoxin reductase; Provisional; Region: PRK10262 396595004007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595004008 FemAB family; Region: FemAB; cl11444 396595004009 Protein of unknown function, DUF482; Region: DUF482; pfam04339 396595004010 Flagellar protein FliS; Region: FliS; cl00654 396595004011 flagellar capping protein; Reviewed; Region: fliD; PRK08032 396595004012 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 396595004013 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 396595004014 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 396595004015 flagellin; Reviewed; Region: PRK08869 396595004016 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 396595004017 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 396595004018 FlaG protein; Region: FlaG; cl00591 396595004019 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 396595004020 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 396595004021 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 396595004022 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 396595004023 catalytic core [active] 396595004024 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 396595004025 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 396595004026 putative dimer interface [polypeptide binding]; other site 396595004027 active site pocket [active] 396595004028 putative cataytic base [active] 396595004029 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 396595004030 homotrimer interface [polypeptide binding]; other site 396595004031 Walker A motif; other site 396595004032 GTP binding site [chemical binding]; other site 396595004033 Walker B motif; other site 396595004034 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 396595004035 cobyric acid synthase; Provisional; Region: PRK00784 396595004036 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 396595004037 catalytic triad [active] 396595004038 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 396595004039 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 396595004040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595004041 homodimer interface [polypeptide binding]; other site 396595004042 catalytic residue [active] 396595004043 CobD/Cbib protein; Region: CobD_Cbib; cl00561 396595004044 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(; Region: BluB; cd02145 396595004045 putative FMN binding site [chemical binding]; other site 396595004046 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144 396595004047 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 396595004048 cobalamin binding residues [chemical binding]; other site 396595004049 putative BtuC binding residues; other site 396595004050 dimer interface [polypeptide binding]; other site 396595004051 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 396595004052 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 396595004053 dimer interface [polypeptide binding]; other site 396595004054 putative PBP binding regions; other site 396595004055 ABC-ATPase subunit interface; other site 396595004056 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 396595004057 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 396595004058 Walker A/P-loop; other site 396595004059 ATP binding site [chemical binding]; other site 396595004060 Q-loop/lid; other site 396595004061 ABC transporter signature motif; other site 396595004062 Walker B; other site 396595004063 D-loop; other site 396595004064 H-loop/switch region; other site 396595004065 Pirin-related protein [General function prediction only]; Region: COG1741 396595004066 Cupin domain; Region: Cupin_2; cl09118 396595004067 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 396595004068 glycerol kinase; Provisional; Region: glpK; PRK00047 396595004069 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 396595004070 N- and C-terminal domain interface [polypeptide binding]; other site 396595004071 active site 396595004072 MgATP binding site [chemical binding]; other site 396595004073 catalytic site [active] 396595004074 metal binding site [ion binding]; metal-binding site 396595004075 glycerol binding site [chemical binding]; other site 396595004076 homotetramer interface [polypeptide binding]; other site 396595004077 homodimer interface [polypeptide binding]; other site 396595004078 FBP binding site [chemical binding]; other site 396595004079 protein IIAGlc interface [polypeptide binding]; other site 396595004080 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 396595004081 dimer interface [polypeptide binding]; other site 396595004082 putative metal binding site [ion binding]; other site 396595004083 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 396595004084 homotrimer interaction site [polypeptide binding]; other site 396595004085 zinc binding site [ion binding]; other site 396595004086 CDP-binding sites; other site 396595004087 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 396595004088 substrate binding site [chemical binding]; other site 396595004089 dimer interface [polypeptide binding]; other site 396595004090 Septum formation initiator; Region: DivIC; cl11433 396595004091 enolase; Provisional; Region: eno; PRK00077 396595004092 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 396595004093 dimer interface [polypeptide binding]; other site 396595004094 metal binding site [ion binding]; metal-binding site 396595004095 substrate binding pocket [chemical binding]; other site 396595004096 NeuB family; Region: NeuB; cl00496 396595004097 CTP synthetase; Validated; Region: pyrG; PRK05380 396595004098 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 396595004099 Catalytic site [active] 396595004100 Active site [active] 396595004101 UTP binding site [chemical binding]; other site 396595004102 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 396595004103 active site 396595004104 putative oxyanion hole; other site 396595004105 catalytic triad [active] 396595004106 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 396595004107 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595004108 metal binding site [ion binding]; metal-binding site 396595004109 active site 396595004110 I-site; other site 396595004111 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 396595004112 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 396595004113 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 396595004114 substrate binding pocket [chemical binding]; other site 396595004115 membrane-bound complex binding site; other site 396595004116 hinge residues; other site 396595004117 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 396595004118 Ligand Binding Site [chemical binding]; other site 396595004119 B3/4 domain; Region: B3_4; cl11458 396595004120 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 396595004121 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 396595004122 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 396595004123 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 396595004124 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 396595004125 generic binding surface II; other site 396595004126 generic binding surface I; other site 396595004127 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 396595004128 RNA/DNA hybrid binding site [nucleotide binding]; other site 396595004129 active site 396595004130 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 396595004131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595004132 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 396595004133 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 396595004134 inhibitor-cofactor binding pocket; inhibition site 396595004135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595004136 catalytic residue [active] 396595004137 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 396595004138 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 396595004139 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 396595004140 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 396595004141 active site 396595004142 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 396595004143 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 396595004144 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 396595004145 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 396595004146 trimer interface [polypeptide binding]; other site 396595004147 active site 396595004148 UDP-GlcNAc binding site [chemical binding]; other site 396595004149 lipid binding site [chemical binding]; lipid-binding site 396595004150 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 396595004151 periplasmic chaperone; Provisional; Region: PRK10780 396595004152 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 396595004153 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 396595004154 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 396595004155 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 396595004156 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 396595004157 Surface antigen; Region: Bac_surface_Ag; cl03097 396595004158 zinc metallopeptidase RseP; Provisional; Region: PRK10779 396595004159 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 396595004160 active site 396595004161 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 396595004162 protein binding site [polypeptide binding]; other site 396595004163 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 396595004164 protein binding site [polypeptide binding]; other site 396595004165 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 396595004166 putative substrate binding region [chemical binding]; other site 396595004167 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 396595004168 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 396595004169 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 396595004170 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 396595004171 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 396595004172 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 396595004173 catalytic residue [active] 396595004174 putative FPP diphosphate binding site; other site 396595004175 putative FPP binding hydrophobic cleft; other site 396595004176 dimer interface [polypeptide binding]; other site 396595004177 putative IPP diphosphate binding site; other site 396595004178 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 396595004179 hinge region; other site 396595004180 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 396595004181 putative nucleotide binding site [chemical binding]; other site 396595004182 uridine monophosphate binding site [chemical binding]; other site 396595004183 homohexameric interface [polypeptide binding]; other site 396595004184 elongation factor Ts; Provisional; Region: tsf; PRK09377 396595004185 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 396595004186 Elongation factor TS; Region: EF_TS; pfam00889 396595004187 Elongation factor TS; Region: EF_TS; pfam00889 396595004188 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 396595004189 rRNA interaction site [nucleotide binding]; other site 396595004190 S8 interaction site; other site 396595004191 putative laminin-1 binding site; other site 396595004192 methionine aminopeptidase; Reviewed; Region: PRK07281 396595004193 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 396595004194 active site 396595004195 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 396595004196 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 396595004197 metal binding triad; other site 396595004198 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 396595004199 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 396595004200 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 396595004201 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 396595004202 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 396595004203 ligand binding site [chemical binding]; other site 396595004204 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 396595004205 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 396595004206 DoxX; Region: DoxX; cl00976 396595004207 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 396595004208 PAS fold; Region: PAS_3; pfam08447 396595004209 PAS domain S-box; Region: sensory_box; TIGR00229 396595004210 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595004211 putative active site [active] 396595004212 heme pocket [chemical binding]; other site 396595004213 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595004214 metal binding site [ion binding]; metal-binding site 396595004215 active site 396595004216 I-site; other site 396595004217 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595004218 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 396595004219 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 396595004220 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 396595004221 active site 396595004222 putative substrate binding pocket [chemical binding]; other site 396595004223 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 396595004224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595004225 S-adenosylmethionine binding site [chemical binding]; other site 396595004226 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 396595004227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 396595004228 motif II; other site 396595004229 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 396595004230 RmuC family; Region: RmuC; pfam02646 396595004231 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 396595004232 active site lid residues [active] 396595004233 substrate binding pocket [chemical binding]; other site 396595004234 catalytic residues [active] 396595004235 substrate-Mg2+ binding site; other site 396595004236 aspartate-rich region 1; other site 396595004237 aspartate-rich region 2; other site 396595004238 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 396595004239 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 396595004240 FeS/SAM binding site; other site 396595004241 HemN C-terminal region; Region: HemN_C; pfam06969 396595004242 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 396595004243 active site lid residues [active] 396595004244 substrate binding pocket [chemical binding]; other site 396595004245 catalytic residues [active] 396595004246 substrate-Mg2+ binding site; other site 396595004247 aspartate-rich region 1; other site 396595004248 aspartate-rich region 2; other site 396595004249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595004250 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 396595004251 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 396595004252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595004253 NAD(P) binding site [chemical binding]; other site 396595004254 active site 396595004255 hypothetical protein; Provisional; Region: PRK01254 396595004256 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 396595004257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 396595004258 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 396595004259 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 396595004260 heme-binding site [chemical binding]; other site 396595004261 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 396595004262 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 396595004263 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 396595004264 active site 396595004265 FMN binding site [chemical binding]; other site 396595004266 substrate binding site [chemical binding]; other site 396595004267 3Fe-4S cluster binding site [ion binding]; other site 396595004268 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 396595004269 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 396595004270 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 396595004271 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 396595004272 YCII-related domain; Region: YCII; cl00999 396595004273 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 396595004274 putative hydrophobic ligand binding site [chemical binding]; other site 396595004275 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 396595004276 Coenzyme A binding pocket [chemical binding]; other site 396595004277 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 396595004278 dimer interface [polypeptide binding]; other site 396595004279 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 396595004280 dimer interface [polypeptide binding]; other site 396595004281 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 396595004282 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 396595004283 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 396595004284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 396595004285 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 396595004286 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 396595004287 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 396595004288 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 396595004289 ligand binding site [chemical binding]; other site 396595004290 oligomer interface [polypeptide binding]; other site 396595004291 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 396595004292 dimer interface [polypeptide binding]; other site 396595004293 N-terminal domain interface [polypeptide binding]; other site 396595004294 sulfate 1 binding site; other site 396595004295 glycogen branching enzyme; Provisional; Region: PRK05402 396595004296 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 396595004297 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 396595004298 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 396595004299 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 396595004300 oligomeric interface; other site 396595004301 putative active site [active] 396595004302 homodimer interface [polypeptide binding]; other site 396595004303 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 396595004304 putative transposase OrfB; Reviewed; Region: PHA02517 396595004305 Integrase core domain; Region: rve; cl01316 396595004306 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 396595004307 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 396595004308 Bacterial sugar transferase; Region: Bac_transf; cl00939 396595004309 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 396595004310 Transposase; Region: DEDD_Tnp_IS110; pfam01548 396595004311 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 396595004312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595004313 NAD(P) binding site [chemical binding]; other site 396595004314 active site 396595004315 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 396595004316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595004317 NAD(P) binding site [chemical binding]; other site 396595004318 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 396595004319 putative ADP-binding pocket [chemical binding]; other site 396595004320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 396595004321 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 396595004322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 396595004323 active site 396595004324 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 396595004325 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 396595004326 active site 396595004327 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 396595004328 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 396595004329 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 396595004330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595004331 Transposase IS200 like; Region: Y1_Tnp; cl00848 396595004332 Transposase IS200 like; Region: Y1_Tnp; cl00848 396595004333 Transposase IS200 like; Region: Y1_Tnp; cl00848 396595004334 Transposase IS200 like; Region: Y1_Tnp; cl00848 396595004335 Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: AIR1; COG5082 396595004336 Protein of unknown function (DUF511); Region: DUF511; cl01114 396595004337 Transposase domain (DUF772); Region: DUF772; cl12084 396595004338 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 396595004339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595004340 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 396595004341 MatE; Region: MatE; cl10513 396595004342 FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 396595004343 putative active site [active] 396595004344 Phd_YefM; Region: PhdYeFM; cl09153 396595004345 FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 396595004346 putative active site [active] 396595004347 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 396595004348 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 396595004349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595004350 Chain length determinant protein; Region: Wzz; cl01623 396595004351 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 396595004352 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 396595004353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595004354 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 396595004355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595004356 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 396595004357 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 396595004358 NAD(P) binding site [chemical binding]; other site 396595004359 homodimer interface [polypeptide binding]; other site 396595004360 substrate binding site [chemical binding]; other site 396595004361 active site 396595004362 Transposase IS200 like; Region: Y1_Tnp; cl00848 396595004363 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 396595004364 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 396595004365 nucleotide binding pocket [chemical binding]; other site 396595004366 K-X-D-G motif; other site 396595004367 catalytic site [active] 396595004368 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 396595004369 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 396595004370 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 396595004371 Dimer interface [polypeptide binding]; other site 396595004372 BRCT sequence motif; other site 396595004373 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 396595004374 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 396595004375 FtsZ protein binding site [polypeptide binding]; other site 396595004376 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 396595004377 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 396595004378 Walker A/P-loop; other site 396595004379 ATP binding site [chemical binding]; other site 396595004380 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 396595004381 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 396595004382 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 396595004383 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 396595004384 ABC transporter signature motif; other site 396595004385 Walker B; other site 396595004386 D-loop; other site 396595004387 H-loop/switch region; other site 396595004388 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 396595004389 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 396595004390 N- and C-terminal domain interface [polypeptide binding]; other site 396595004391 active site 396595004392 MgATP binding site [chemical binding]; other site 396595004393 catalytic site [active] 396595004394 metal binding site [ion binding]; metal-binding site 396595004395 carbohydrate binding site [chemical binding]; other site 396595004396 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 396595004397 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 396595004398 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 396595004399 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 396595004400 substrate binding pocket [chemical binding]; other site 396595004401 membrane-bound complex binding site; other site 396595004402 hinge residues; other site 396595004403 UPF0126 domain; Region: UPF0126; pfam03458 396595004404 UPF0126 domain; Region: UPF0126; pfam03458 396595004405 NMT1/THI5 like; Region: NMT1; pfam09084 396595004406 Cache domain; Region: Cache_1; pfam02743 396595004407 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 396595004408 dimerization interface [polypeptide binding]; other site 396595004409 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 396595004410 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 396595004411 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 396595004412 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 396595004413 [2Fe-2S] cluster binding site [ion binding]; other site 396595004414 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 396595004415 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 396595004416 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 396595004417 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 396595004418 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 396595004419 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 396595004420 sensory histidine kinase AtoS; Provisional; Region: PRK11360 396595004421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595004422 ATP binding site [chemical binding]; other site 396595004423 Mg2+ binding site [ion binding]; other site 396595004424 G-X-G motif; other site 396595004425 response regulator PleD; Reviewed; Region: pleD; PRK09581 396595004426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595004427 active site 396595004428 phosphorylation site [posttranslational modification] 396595004429 intermolecular recognition site; other site 396595004430 dimerization interface [polypeptide binding]; other site 396595004431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595004432 putative active site [active] 396595004433 heme pocket [chemical binding]; other site 396595004434 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595004435 metal binding site [ion binding]; metal-binding site 396595004436 active site 396595004437 I-site; other site 396595004438 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595004439 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 396595004440 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 396595004441 substrate binding pocket [chemical binding]; other site 396595004442 membrane-bound complex binding site; other site 396595004443 hinge residues; other site 396595004444 PAS fold; Region: PAS_3; pfam08447 396595004445 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595004446 metal binding site [ion binding]; metal-binding site 396595004447 active site 396595004448 I-site; other site 396595004449 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595004450 Glycerate kinase family; Region: Gly_kinase; cl00841 396595004451 GntP family permease; Region: GntP_permease; cl15264 396595004452 GntP family permease; Region: GntP_permease; cl15264 396595004453 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 396595004454 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 396595004455 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 396595004456 GIY-YIG motif/motif A; other site 396595004457 active site 396595004458 catalytic site [active] 396595004459 putative DNA binding site [nucleotide binding]; other site 396595004460 metal binding site [ion binding]; metal-binding site 396595004461 UvrB/uvrC motif; Region: UVR; pfam02151 396595004462 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 396595004463 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 396595004464 Fe-S cluster binding site [ion binding]; other site 396595004465 DNA binding site [nucleotide binding] 396595004466 active site 396595004467 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 396595004468 putative active site [active] 396595004469 putative metal binding residues [ion binding]; other site 396595004470 signature motif; other site 396595004471 putative dimer interface [polypeptide binding]; other site 396595004472 putative phosphate binding site [ion binding]; other site 396595004473 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 396595004474 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 396595004475 dimer interface [polypeptide binding]; other site 396595004476 active site 396595004477 CoA binding pocket [chemical binding]; other site 396595004478 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 396595004479 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 396595004480 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 396595004481 pyruvate carboxylase subunit A; Validated; Region: PRK07178 396595004482 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 396595004483 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 396595004484 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 396595004485 pyruvate carboxylase subunit B; Validated; Region: PRK09282 396595004486 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 396595004487 active site 396595004488 catalytic residues [active] 396595004489 metal binding site [ion binding]; metal-binding site 396595004490 homodimer binding site [polypeptide binding]; other site 396595004491 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 396595004492 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 396595004493 carboxyltransferase (CT) interaction site; other site 396595004494 biotinylation site [posttranslational modification]; other site 396595004495 Maf-like protein; Region: Maf; pfam02545 396595004496 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 396595004497 active site 396595004498 dimer interface [polypeptide binding]; other site 396595004499 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 396595004500 dimerization interface [polypeptide binding]; other site 396595004501 putative DNA binding site [nucleotide binding]; other site 396595004502 putative Zn2+ binding site [ion binding]; other site 396595004503 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 396595004504 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 396595004505 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 396595004506 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 396595004507 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 396595004508 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 396595004509 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 396595004510 Global regulator protein family; Region: CsrA; cl00670 396595004511 aspartate kinase; Reviewed; Region: PRK06635 396595004512 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 396595004513 putative nucleotide binding site [chemical binding]; other site 396595004514 putative catalytic residues [active] 396595004515 putative Mg ion binding site [ion binding]; other site 396595004516 putative aspartate binding site [chemical binding]; other site 396595004517 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 396595004518 putative allosteric regulatory site; other site 396595004519 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 396595004520 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 396595004521 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 396595004522 motif 1; other site 396595004523 active site 396595004524 motif 2; other site 396595004525 motif 3; other site 396595004526 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 396595004527 DHHA1 domain; Region: DHHA1; pfam02272 396595004528 RecX family; Region: RecX; cl00936 396595004529 recombinase A; Provisional; Region: recA; PRK09354 396595004530 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 396595004531 hexamer interface [polypeptide binding]; other site 396595004532 Walker A motif; other site 396595004533 ATP binding site [chemical binding]; other site 396595004534 Walker B motif; other site 396595004535 Competence-damaged protein; Region: CinA; cl00666 396595004536 PilZ domain; Region: PilZ; cl01260 396595004537 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 396595004538 MutS domain I; Region: MutS_I; pfam01624 396595004539 MutS domain II; Region: MutS_II; pfam05188 396595004540 MutS family domain IV; Region: MutS_IV; pfam05190 396595004541 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 396595004542 Walker A/P-loop; other site 396595004543 ATP binding site [chemical binding]; other site 396595004544 Q-loop/lid; other site 396595004545 ABC transporter signature motif; other site 396595004546 Walker B; other site 396595004547 D-loop; other site 396595004548 H-loop/switch region; other site 396595004549 NodT family; Region: outer_NodT; TIGR01845 396595004550 Outer membrane efflux protein; Region: OEP; pfam02321 396595004551 Outer membrane efflux protein; Region: OEP; pfam02321 396595004552 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 396595004553 Protein export membrane protein; Region: SecD_SecF; cl14618 396595004554 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 396595004555 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 396595004556 Putative ATPase (DUF699); Region: DUF699; pfam05127 396595004557 UvrD/REP helicase; Region: UvrD-helicase; cl14126 396595004558 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 396595004559 UvrD/REP helicase; Region: UvrD-helicase; cl14126 396595004560 UvrD/REP helicase; Region: UvrD-helicase; cl14126 396595004561 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 396595004562 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 396595004563 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 396595004564 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 396595004565 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 396595004566 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 396595004567 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 396595004568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 396595004569 putative PBP binding loops; other site 396595004570 dimer interface [polypeptide binding]; other site 396595004571 ABC-ATPase subunit interface; other site 396595004572 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595004573 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 396595004574 Walker A/P-loop; other site 396595004575 ATP binding site [chemical binding]; other site 396595004576 Q-loop/lid; other site 396595004577 ABC transporter signature motif; other site 396595004578 Walker B; other site 396595004579 D-loop; other site 396595004580 H-loop/switch region; other site 396595004581 Integrase core domain; Region: rve; cl01316 396595004582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 396595004583 non-specific DNA binding site [nucleotide binding]; other site 396595004584 salt bridge; other site 396595004585 sequence-specific DNA binding site [nucleotide binding]; other site 396595004586 HsdM N-terminal domain; Region: HsdM_N; pfam12161 396595004587 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 396595004588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595004589 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 396595004590 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 396595004591 Virulence protein [General function prediction only]; Region: COG3943 396595004592 Fic/DOC family; Region: Fic; cl00960 396595004593 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 396595004594 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 396595004595 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595004596 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 396595004597 nucleotide binding region [chemical binding]; other site 396595004598 ATP-binding site [chemical binding]; other site 396595004599 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 396595004600 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 396595004601 catalytic residues [active] 396595004602 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 396595004603 pyruvate kinase; Provisional; Region: PRK05826 396595004604 domain interfaces; other site 396595004605 active site 396595004606 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 396595004607 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 396595004608 conserved cys residue [active] 396595004609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 396595004610 OsmC-like protein; Region: OsmC; cl00767 396595004611 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 396595004612 transmembrane helices; other site 396595004613 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 396595004614 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 396595004615 translocation protein TolB; Provisional; Region: tolB; PRK04792 396595004616 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 396595004617 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 396595004618 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 396595004619 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 396595004620 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 396595004621 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 396595004622 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 396595004623 putative transposase OrfB; Reviewed; Region: PHA02517 396595004624 Integrase core domain; Region: rve; cl01316 396595004625 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 396595004626 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 396595004627 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 396595004628 active site residue [active] 396595004629 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 396595004630 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 396595004631 nudix motif; other site 396595004632 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 396595004633 putative hexamer interface [polypeptide binding]; other site 396595004634 putative hexagonal pore; other site 396595004635 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 396595004636 putative hexamer interface [polypeptide binding]; other site 396595004637 putative hexagonal pore; other site 396595004638 Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053 396595004639 diiron binding motif [ion binding]; other site 396595004640 DsrE/DsrF-like family; Region: DrsE; cl00672 396595004641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 396595004642 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595004643 metal binding site [ion binding]; metal-binding site 396595004644 active site 396595004645 I-site; other site 396595004646 Predicted membrane protein [Function unknown]; Region: COG2119 396595004647 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 396595004648 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 396595004649 Site-specific recombinase; Region: SpecificRecomb; pfam10136 396595004650 Site-specific recombinase [DNA replication, recombination, and repair]; Region: COG4389 396595004651 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 396595004652 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 396595004653 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 396595004654 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595004655 metal binding site [ion binding]; metal-binding site 396595004656 active site 396595004657 I-site; other site 396595004658 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595004659 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 396595004660 Protein required for attachment to host cells; Region: Host_attach; cl02398 396595004661 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 396595004662 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 396595004663 catalytic core [active] 396595004664 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 396595004665 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 396595004666 catalytic core [active] 396595004667 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 396595004668 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings...; Region: proteasome_beta_bacterial; cd03765 396595004669 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 396595004670 Uncharacterized conserved protein [Function unknown]; Region: COG2308 396595004671 Domain of unknown function (DUF404); Region: DUF404; pfam04169 396595004672 Domain of unknown function (DUF407); Region: DUF407; pfam04174 396595004673 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 396595004674 tetramer interfaces [polypeptide binding]; other site 396595004675 binuclear metal-binding site [ion binding]; other site 396595004676 thiamine monophosphate kinase; Provisional; Region: PRK05731 396595004677 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 396595004678 ATP binding site [chemical binding]; other site 396595004679 dimerization interface [polypeptide binding]; other site 396595004680 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 396595004681 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 396595004682 homopentamer interface [polypeptide binding]; other site 396595004683 active site 396595004684 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 396595004685 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 396595004686 Moco binding site; other site 396595004687 metal coordination site [ion binding]; other site 396595004688 Transposase IS200 like; Region: Y1_Tnp; cl00848 396595004689 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 396595004690 Transposase; Region: DEDD_Tnp_IS110; pfam01548 396595004691 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 396595004692 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 396595004693 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 396595004694 Walker A/P-loop; other site 396595004695 ATP binding site [chemical binding]; other site 396595004696 Q-loop/lid; other site 396595004697 ABC transporter signature motif; other site 396595004698 Walker B; other site 396595004699 D-loop; other site 396595004700 H-loop/switch region; other site 396595004701 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 396595004702 MgtE intracellular N domain; Region: MgtE_N; cl15244 396595004703 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 396595004704 Divalent cation transporter; Region: MgtE; cl00786 396595004705 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 396595004706 MgtE intracellular N domain; Region: MgtE_N; cl15244 396595004707 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 396595004708 Divalent cation transporter; Region: MgtE; cl00786 396595004709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 396595004710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595004711 S-adenosylmethionine binding site [chemical binding]; other site 396595004712 Ion transport protein; Region: Ion_trans; pfam00520 396595004713 Phd_YefM; Region: PhdYeFM; cl09153 396595004714 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 396595004715 Protein of unknown function (DUF497); Region: DUF497; cl01108 396595004716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 396595004717 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 396595004718 Phd_YefM; Region: PhdYeFM; cl09153 396595004719 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 396595004720 putative active site [active] 396595004721 Ion transport protein; Region: Ion_trans; pfam00520 396595004722 Myosin-like coiled-coil protein; Region: Taxilin; pfam09728 396595004723 Transposase; Region: DEDD_Tnp_IS110; pfam01548 396595004724 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 396595004725 2-isopropylmalate synthase; Validated; Region: PRK03739 396595004726 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 396595004727 active site 396595004728 catalytic residues [active] 396595004729 metal binding site [ion binding]; metal-binding site 396595004730 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 396595004731 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 396595004732 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595004733 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 396595004734 dimer interface [polypeptide binding]; other site 396595004735 putative PBP binding regions; other site 396595004736 ABC-ATPase subunit interface; other site 396595004737 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 396595004738 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595004739 Walker A/P-loop; other site 396595004740 ATP binding site [chemical binding]; other site 396595004741 Q-loop/lid; other site 396595004742 ABC transporter signature motif; other site 396595004743 Walker B; other site 396595004744 D-loop; other site 396595004745 H-loop/switch region; other site 396595004746 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 396595004747 intersubunit interface [polypeptide binding]; other site 396595004748 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 396595004749 metal binding site [ion binding]; metal-binding site 396595004750 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 396595004751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595004752 putative active site [active] 396595004753 heme pocket [chemical binding]; other site 396595004754 hypothetical protein; Provisional; Region: PRK13560 396595004755 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 396595004756 hypothetical protein; Provisional; Region: PRK13560 396595004757 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 396595004758 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 396595004759 PAS domain S-box; Region: sensory_box; TIGR00229 396595004760 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595004761 putative active site [active] 396595004762 heme pocket [chemical binding]; other site 396595004763 hypothetical protein; Provisional; Region: PRK13560 396595004764 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 396595004765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 396595004766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595004767 PAS fold; Region: PAS_3; pfam08447 396595004768 putative active site [active] 396595004769 heme pocket [chemical binding]; other site 396595004770 PAS domain S-box; Region: sensory_box; TIGR00229 396595004771 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595004772 putative active site [active] 396595004773 heme pocket [chemical binding]; other site 396595004774 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595004775 metal binding site [ion binding]; metal-binding site 396595004776 active site 396595004777 I-site; other site 396595004778 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 396595004779 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 396595004780 tetramer interface [polypeptide binding]; other site 396595004781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595004782 catalytic residue [active] 396595004783 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 396595004784 dimer interface [polypeptide binding]; other site 396595004785 catalytic triad [active] 396595004786 peroxidatic and resolving cysteines [active] 396595004787 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 396595004788 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 396595004789 tetramer interface [polypeptide binding]; other site 396595004790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595004791 catalytic residue [active] 396595004792 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 396595004793 lipoyl attachment site [posttranslational modification]; other site 396595004794 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 396595004795 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 396595004796 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 396595004797 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 396595004798 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 396595004799 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 396595004800 dimerization interface [polypeptide binding]; other site 396595004801 active site 396595004802 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 396595004803 ScpA/B protein; Region: ScpA_ScpB; cl00598 396595004804 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 396595004805 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 396595004806 active site 396595004807 HIGH motif; other site 396595004808 dimer interface [polypeptide binding]; other site 396595004809 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 396595004810 active site 396595004811 KMSKS motif; other site 396595004812 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 396595004813 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 396595004814 YCII-related domain; Region: YCII; cl00999 396595004815 PPIC-type PPIASE domain; Region: Rotamase; cl08278 396595004816 Protein of unknown function (DUF461); Region: DUF461; cl01071 396595004817 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 396595004818 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 396595004819 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 396595004820 endonuclease III; Provisional; Region: PRK10702 396595004821 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 396595004822 minor groove reading motif; other site 396595004823 helix-hairpin-helix signature motif; other site 396595004824 substrate binding pocket [chemical binding]; other site 396595004825 active site 396595004826 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 396595004827 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 396595004828 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 396595004829 hydrophobic ligand binding site; other site 396595004830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 396595004831 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 396595004832 putative substrate translocation pore; other site 396595004833 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 396595004834 Tetramer interface [polypeptide binding]; other site 396595004835 Active site [active] 396595004836 FMN-binding site [chemical binding]; other site 396595004837 Domain of unknown function (DUF336); Region: DUF336; cl01249 396595004838 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 396595004839 active site residue [active] 396595004840 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 396595004841 C-term; Region: GreA_GreB; pfam01272 396595004842 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 396595004843 active site residue [active] 396595004844 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 396595004845 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 396595004846 lipoyl attachment site [posttranslational modification]; other site 396595004847 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275 396595004848 Uncharacterized conserved protein [Function unknown]; Region: COG3945 396595004849 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cl00436 396595004850 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 396595004851 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 396595004852 substrate binding pocket [chemical binding]; other site 396595004853 membrane-bound complex binding site; other site 396595004854 hinge residues; other site 396595004855 PAS domain S-box; Region: sensory_box; TIGR00229 396595004856 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 396595004857 PAS domain S-box; Region: sensory_box; TIGR00229 396595004858 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595004859 putative active site [active] 396595004860 heme pocket [chemical binding]; other site 396595004861 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 396595004862 GAF domain; Region: GAF; cl00853 396595004863 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595004864 metal binding site [ion binding]; metal-binding site 396595004865 active site 396595004866 I-site; other site 396595004867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 396595004868 putative substrate translocation pore; other site 396595004869 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 396595004870 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 396595004871 minor groove reading motif; other site 396595004872 helix-hairpin-helix signature motif; other site 396595004873 substrate binding pocket [chemical binding]; other site 396595004874 active site 396595004875 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 396595004876 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 396595004877 probable active site [active] 396595004878 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 396595004879 MPT binding site; other site 396595004880 trimer interface [polypeptide binding]; other site 396595004881 Protein of unknown function, DUF488; Region: DUF488; cl01246 396595004882 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 396595004883 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 396595004884 active site 396595004885 dimer interface [polypeptide binding]; other site 396595004886 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 396595004887 Ligand Binding Site [chemical binding]; other site 396595004888 Molecular Tunnel; other site 396595004889 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595004890 Transcriptional regulator [Transcription]; Region: LysR; COG0583 396595004891 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 396595004892 dimerization interface [polypeptide binding]; other site 396595004893 ORF6N domain; Region: ORF6N; pfam10543 396595004894 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 396595004895 putative inner membrane peptidase; Provisional; Region: PRK11778 396595004896 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 396595004897 tandem repeat interface [polypeptide binding]; other site 396595004898 oligomer interface [polypeptide binding]; other site 396595004899 active site residues [active] 396595004900 DsrE/DsrF-like family; Region: DrsE; cl00672 396595004901 DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625 396595004902 putative ligand binding site [chemical binding]; other site 396595004903 Membrane transport protein; Region: Mem_trans; cl09117 396595004904 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 396595004905 FeS/SAM binding site; other site 396595004906 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 396595004907 Domain of unknown function DUF302; Region: DUF302; cl01364 396595004908 Protein of unknown function (DUF785); Region: DUF785; cl01682 396595004909 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 396595004910 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 396595004911 Predicted deacylase [General function prediction only]; Region: COG3608 396595004912 A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the...; Region: M14_ASTE_ASPA_like_1; cd06251 396595004913 putative active site [active] 396595004914 Zn-binding site [ion binding]; other site 396595004915 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 396595004916 catalytic residues [active] 396595004917 Sulfatase; Region: Sulfatase; cl10460 396595004918 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 396595004919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 396595004920 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 396595004921 RF-1 domain; Region: RF-1; cl02875 396595004922 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 396595004923 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 396595004924 G1 box; other site 396595004925 putative GEF interaction site [polypeptide binding]; other site 396595004926 GTP/Mg2+ binding site [chemical binding]; other site 396595004927 Switch I region; other site 396595004928 G2 box; other site 396595004929 G3 box; other site 396595004930 Switch II region; other site 396595004931 G4 box; other site 396595004932 G5 box; other site 396595004933 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 396595004934 Sel1 repeat; Region: Sel1; cl02723 396595004935 Sel1 repeat; Region: Sel1; cl02723 396595004936 Sel1 repeat; Region: Sel1; cl02723 396595004937 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 396595004938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 396595004939 Coenzyme A binding pocket [chemical binding]; other site 396595004940 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 396595004941 Fe-S cluster binding site [ion binding]; other site 396595004942 active site 396595004943 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 396595004944 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 396595004945 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 396595004946 ketol-acid reductoisomerase; Provisional; Region: PRK05479 396595004947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595004948 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 396595004949 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 396595004950 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 396595004951 putative valine binding site [chemical binding]; other site 396595004952 dimer interface [polypeptide binding]; other site 396595004953 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 396595004954 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 396595004955 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 396595004956 PYR/PP interface [polypeptide binding]; other site 396595004957 dimer interface [polypeptide binding]; other site 396595004958 TPP binding site [chemical binding]; other site 396595004959 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 396595004960 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 396595004961 TPP-binding site [chemical binding]; other site 396595004962 dimer interface [polypeptide binding]; other site 396595004963 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 396595004964 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 396595004965 putative substrate binding site [chemical binding]; other site 396595004966 nucleotide binding site [chemical binding]; other site 396595004967 nucleotide binding site [chemical binding]; other site 396595004968 homodimer interface [polypeptide binding]; other site 396595004969 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 396595004970 trimer interface [polypeptide binding]; other site 396595004971 active site 396595004972 Domain of unknown function DUF59; Region: DUF59; cl00941 396595004973 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 396595004974 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 396595004975 Walker A motif; other site 396595004976 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 396595004977 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 396595004978 active site 396595004979 HIGH motif; other site 396595004980 KMSKS motif; other site 396595004981 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 396595004982 tRNA binding surface [nucleotide binding]; other site 396595004983 anticodon binding site; other site 396595004984 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 396595004985 dimer interface [polypeptide binding]; other site 396595004986 putative tRNA-binding site [nucleotide binding]; other site 396595004987 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 396595004988 intersubunit interface [polypeptide binding]; other site 396595004989 active site 396595004990 Zn2+ binding site [ion binding]; other site 396595004991 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 396595004992 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 396595004993 electron transport complex protein RnfB; Provisional; Region: PRK05113 396595004994 Putative Fe-S cluster; Region: FeS; pfam04060 396595004995 4Fe-4S binding domain; Region: Fer4; cl02805 396595004996 C subunit; Region: rnfC; TIGR01945 396595004997 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 396595004998 SLBB domain; Region: SLBB; pfam10531 396595004999 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 396595005000 RnfE family; Region: NQR2_RnfD_RnfE; cl00779 396595005001 FMN-binding domain; Region: FMN_bind; cl01081 396595005002 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 396595005003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595005004 Sulfate transporter family; Region: Sulfate_transp; cl00967 396595005005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 396595005006 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 396595005007 homodecamer interface [polypeptide binding]; other site 396595005008 GTP cyclohydrolase I; Provisional; Region: PLN03044 396595005009 active site 396595005010 putative catalytic site residues [active] 396595005011 zinc binding site [ion binding]; other site 396595005012 GTP-CH-I/GFRP interaction surface; other site 396595005013 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 396595005014 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 396595005015 catalytic residues [active] 396595005016 dimer interface [polypeptide binding]; other site 396595005017 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 396595005018 Protein of unknown function (DUF1365); Region: DUF1365; cl01388 396595005019 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 396595005020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595005021 S-adenosylmethionine binding site [chemical binding]; other site 396595005022 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 396595005023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 396595005024 Coenzyme A binding pocket [chemical binding]; other site 396595005025 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 396595005026 active site 396595005027 NTP binding site [chemical binding]; other site 396595005028 metal binding triad [ion binding]; metal-binding site 396595005029 antibiotic binding site [chemical binding]; other site 396595005030 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 396595005031 Transposase, Mutator family; Region: Transposase_mut; pfam00872 396595005032 MULE transposase domain; Region: MULE; pfam10551 396595005033 Transposase IS200 like; Region: Y1_Tnp; cl00848 396595005034 Transposase IS200 like; Region: Y1_Tnp; cl00848 396595005035 Transposase IS200 like; Region: Y1_Tnp; cl00848 396595005036 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 396595005037 trimer interface [polypeptide binding]; other site 396595005038 eyelet of channel; other site 396595005039 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 396595005040 homotetrameric interface [polypeptide binding]; other site 396595005041 putative active site [active] 396595005042 metal binding site [ion binding]; metal-binding site 396595005043 Phd_YefM; Region: PhdYeFM; cl09153 396595005044 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 396595005045 active site 396595005046 NTP binding site [chemical binding]; other site 396595005047 metal binding triad [ion binding]; metal-binding site 396595005048 antibiotic binding site [chemical binding]; other site 396595005049 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 396595005050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595005051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595005052 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 396595005053 proline aminopeptidase P II; Provisional; Region: PRK10879 396595005054 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 396595005055 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 396595005056 active site 396595005057 Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173 396595005058 TIGR02449 family protein; Region: TIGR02449 396595005059 Cell division protein ZapA; Region: ZapA; cl01146 396595005060 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 396595005061 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 396595005062 DNA translocase FtsK; Provisional; Region: PRK10263 396595005063 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 396595005064 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595005065 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 396595005066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595005067 potassium/proton antiporter; Reviewed; Region: PRK05326 396595005068 Transporter associated domain; Region: CorC_HlyC; cl08393 396595005069 LexA repressor; Validated; Region: PRK00215 396595005070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595005071 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 396595005072 Catalytic site [active] 396595005073 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595005074 Walker A motif; other site 396595005075 ATP binding site [chemical binding]; other site 396595005076 Cell division inhibitor SulA; Region: SulA; cl01880 396595005077 DNA Polymerase Y-family; Region: PolY_like; cd03468 396595005078 active site 396595005079 DNA binding site [nucleotide binding] 396595005080 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 396595005081 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 396595005082 putative NAD(P) binding site [chemical binding]; other site 396595005083 active site 396595005084 putative substrate binding site [chemical binding]; other site 396595005085 Septum formation topological specificity factor MinE; Region: MinE; cl00538 396595005086 cell division inhibitor MinD; Provisional; Region: PRK10818 396595005087 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 396595005088 Switch I; other site 396595005089 Switch II; other site 396595005090 septum formation inhibitor; Reviewed; Region: minC; PRK00339 396595005091 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 396595005092 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 396595005093 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 396595005094 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 396595005095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595005096 S-adenosylmethionine binding site [chemical binding]; other site 396595005097 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 396595005098 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 396595005099 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 396595005100 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 396595005101 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 396595005102 dihydrodipicolinate reductase; Provisional; Region: PRK00048 396595005103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595005104 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 396595005105 HemK family putative methylases; Region: hemK_fam; TIGR00536 396595005106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595005107 S-adenosylmethionine binding site [chemical binding]; other site 396595005108 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 396595005109 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 396595005110 putative active site [active] 396595005111 putative substrate binding site [chemical binding]; other site 396595005112 catalytic site [active] 396595005113 dimer interface [polypeptide binding]; other site 396595005114 Cytochrome c; Region: Cytochrom_C; cl11414 396595005115 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 396595005116 aromatic arch; other site 396595005117 DCoH dimer interaction site [polypeptide binding]; other site 396595005118 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 396595005119 DCoH tetramer interaction site [polypeptide binding]; other site 396595005120 substrate binding site [chemical binding]; other site 396595005121 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 396595005122 GTPase/OB domain interface [polypeptide binding]; other site 396595005123 GTPase RsgA; Reviewed; Region: PRK00098 396595005124 GTPase/Zn-binding domain interface [polypeptide binding]; other site 396595005125 GTP/Mg2+ binding site [chemical binding]; other site 396595005126 G4 box; other site 396595005127 G5 box; other site 396595005128 G1 box; other site 396595005129 Switch I region; other site 396595005130 G2 box; other site 396595005131 G3 box; other site 396595005132 Switch II region; other site 396595005133 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 396595005134 nucleotide binding site/active site [active] 396595005135 HIT family signature motif; other site 396595005136 catalytic residue [active] 396595005137 recombination protein RecR; Reviewed; Region: recR; PRK00076 396595005138 RecR protein; Region: RecR; pfam02132 396595005139 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 396595005140 putative active site [active] 396595005141 putative metal-binding site [ion binding]; other site 396595005142 tetramer interface [polypeptide binding]; other site 396595005143 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 396595005144 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969 396595005145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595005146 Walker A motif; other site 396595005147 ATP binding site [chemical binding]; other site 396595005148 Walker B motif; other site 396595005149 arginine finger; other site 396595005150 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 396595005151 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 396595005152 catalytic triad [active] 396595005153 dimer interface [polypeptide binding]; other site 396595005154 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 396595005155 glutathione reductase; Validated; Region: PRK06116 396595005156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595005157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595005158 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 396595005159 Surface antigen; Region: Surface_Ag_2; cl01155 396595005160 CsbD-like; Region: CsbD; cl01272 396595005161 hypothetical protein; Provisional; Region: PRK13682 396595005162 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 396595005163 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 396595005164 ligand binding site [chemical binding]; other site 396595005165 flexible hinge region; other site 396595005166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595005167 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 396595005168 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain...; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 396595005169 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 396595005170 metal binding triad; other site 396595005171 Predicted membrane protein [Function unknown]; Region: COG4327; cl01781 396595005172 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 396595005173 Sodium:solute symporter family; Region: SSF; cl00456 396595005174 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 396595005175 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain...; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 396595005176 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 396595005177 metal binding triad; other site 396595005178 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 396595005179 active site 396595005180 substrate binding site [chemical binding]; other site 396595005181 catalytic site [active] 396595005182 acetyl-CoA synthetase; Provisional; Region: PRK00174 396595005183 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 396595005184 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 396595005185 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595005186 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595005187 PAS fold; Region: PAS_3; pfam08447 396595005188 putative active site [active] 396595005189 heme pocket [chemical binding]; other site 396595005190 PAS domain S-box; Region: sensory_box; TIGR00229 396595005191 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 396595005192 putative active site [active] 396595005193 heme pocket [chemical binding]; other site 396595005194 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595005195 metal binding site [ion binding]; metal-binding site 396595005196 active site 396595005197 I-site; other site 396595005198 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595005199 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 396595005200 anti sigma factor interaction site; other site 396595005201 regulatory phosphorylation site [posttranslational modification]; other site 396595005202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 396595005203 NifU-like domain; Region: NifU; cl00484 396595005204 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 396595005205 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 396595005206 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 396595005207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595005208 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 396595005209 domain; Region: Succ_DH_flav_C; pfam02910 396595005210 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 396595005211 SdhC subunit interface [polypeptide binding]; other site 396595005212 proximal heme binding site [chemical binding]; other site 396595005213 cardiolipin binding site; other site 396595005214 Iron-sulfur protein interface; other site 396595005215 proximal quinone binding site [chemical binding]; other site 396595005216 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 396595005217 Iron-sulfur protein interface; other site 396595005218 proximal quinone binding site [chemical binding]; other site 396595005219 SdhD (CybS) interface [polypeptide binding]; other site 396595005220 proximal heme binding site [chemical binding]; other site 396595005221 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 396595005222 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 396595005223 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 396595005224 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 396595005225 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 396595005226 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 396595005227 dimerization interface [polypeptide binding]; other site 396595005228 active site 396595005229 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 396595005230 Lumazine binding domain; Region: Lum_binding; pfam00677 396595005231 Lumazine binding domain; Region: Lum_binding; pfam00677 396595005232 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 396595005233 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 396595005234 catalytic motif [active] 396595005235 Zn binding site [ion binding]; other site 396595005236 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 396595005237 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 396595005238 ATP cone domain; Region: ATP-cone; pfam03477 396595005239 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 396595005240 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 396595005241 dimer interface [polypeptide binding]; other site 396595005242 glycine-pyridoxal phosphate binding site [chemical binding]; other site 396595005243 active site 396595005244 folate binding site [chemical binding]; other site 396595005245 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 396595005246 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 396595005247 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 396595005248 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 396595005249 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 396595005250 Domain of unknown function DUF302; Region: DUF302; cl01364 396595005251 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 396595005252 FAD binding domain; Region: FAD_binding_4; pfam01565 396595005253 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 396595005254 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 396595005255 Cysteine-rich domain; Region: CCG; pfam02754 396595005256 Cysteine-rich domain; Region: CCG; pfam02754 396595005257 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 396595005258 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-...; Region: AGAT_like; cd06451 396595005259 homodimer interface [polypeptide binding]; other site 396595005260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595005261 catalytic residue [active] 396595005262 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 396595005263 active site 396595005264 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 396595005265 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 396595005266 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 396595005267 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 396595005268 putative acyl-acceptor binding pocket; other site 396595005269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 396595005270 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 396595005271 active site residue [active] 396595005272 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 396595005273 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein...; Region: SSP411; cd02955 396595005274 catalytic residues [active] 396595005275 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 396595005276 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 396595005277 dimerization interface [polypeptide binding]; other site 396595005278 active site 396595005279 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 396595005280 folate binding site [chemical binding]; other site 396595005281 NADP+ binding site [chemical binding]; other site 396595005282 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 396595005283 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 396595005284 Beta-Casp domain; Region: Beta-Casp; cl12567 396595005285 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 396595005286 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 396595005287 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 396595005288 Adenylation domain of RNA circularization proteins; Region: Adenylation_RNA_ligase; cd07894 396595005289 active site 396595005290 dimer interface [polypeptide binding]; other site 396595005291 UPF0278 family; Region: UPF0278; cl00637 396595005292 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 396595005293 Sensors of blue-light using FAD; Region: BLUF; cl04855 396595005294 GMP synthase; Reviewed; Region: guaA; PRK00074 396595005295 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 396595005296 AMP/PPi binding site [chemical binding]; other site 396595005297 candidate oxyanion hole; other site 396595005298 catalytic triad [active] 396595005299 potential glutamine specificity residues [chemical binding]; other site 396595005300 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 396595005301 ATP Binding subdomain [chemical binding]; other site 396595005302 Dimerization subdomain; other site 396595005303 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 396595005304 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 396595005305 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 396595005306 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 396595005307 active site 396595005308 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 396595005309 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 396595005310 generic binding surface I; other site 396595005311 generic binding surface II; other site 396595005312 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 396595005313 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 396595005314 HIGH motif; other site 396595005315 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 396595005316 active site 396595005317 KMSKS motif; other site 396595005318 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 396595005319 substrate binding site [chemical binding]; other site 396595005320 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 396595005321 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 396595005322 putative active site [active] 396595005323 putative metal binding site [ion binding]; other site 396595005324 NodT family; Region: outer_NodT; TIGR01845 396595005325 Outer membrane efflux protein; Region: OEP; pfam02321 396595005326 Outer membrane efflux protein; Region: OEP; pfam02321 396595005327 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 396595005328 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 396595005329 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 396595005330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 396595005331 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 396595005332 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 396595005333 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 396595005334 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 396595005335 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 396595005336 metal-binding site [ion binding] 396595005337 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 396595005338 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 396595005339 metal-binding site [ion binding] 396595005340 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 396595005341 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 396595005342 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 396595005343 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 396595005344 putative active site [active] 396595005345 catalytic site [active] 396595005346 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 396595005347 putative active site [active] 396595005348 catalytic site [active] 396595005349 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 396595005350 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 396595005351 homodimer interface [polypeptide binding]; other site 396595005352 substrate-cofactor binding pocket; other site 396595005353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595005354 catalytic residue [active] 396595005355 alanine racemase; Reviewed; Region: alr; PRK00053 396595005356 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 396595005357 active site 396595005358 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 396595005359 substrate binding site [chemical binding]; other site 396595005360 catalytic residues [active] 396595005361 dimer interface [polypeptide binding]; other site 396595005362 replicative DNA helicase; Region: DnaB; TIGR00665 396595005363 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 396595005364 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 396595005365 Walker A motif; other site 396595005366 ATP binding site [chemical binding]; other site 396595005367 Walker B motif; other site 396595005368 DNA binding loops [nucleotide binding] 396595005369 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 396595005370 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 396595005371 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 396595005372 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 396595005373 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 396595005374 Cytochrome c; Region: Cytochrom_C; cl11414 396595005375 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 396595005376 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 396595005377 ribonuclease R; Region: RNase_R; TIGR02063 396595005378 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 396595005379 RNB domain; Region: RNB; pfam00773 396595005380 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 396595005381 RNA binding site [nucleotide binding]; other site 396595005382 adenylosuccinate synthetase; Provisional; Region: PRK01117 396595005383 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 396595005384 GDP-binding site [chemical binding]; other site 396595005385 ACT binding site; other site 396595005386 IMP binding site; other site 396595005387 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 396595005388 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 396595005389 dimer interface [polypeptide binding]; other site 396595005390 motif 1; other site 396595005391 active site 396595005392 motif 2; other site 396595005393 motif 3; other site 396595005394 FtsH protease regulator HflC; Provisional; Region: PRK11029 396595005395 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 396595005396 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 396595005397 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 396595005398 HflK protein; Region: hflK; TIGR01933 396595005399 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 396595005400 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 396595005401 active site 396595005402 hydrophilic channel; other site 396595005403 dimerization interface [polypeptide binding]; other site 396595005404 catalytic residues [active] 396595005405 active site lid [active] 396595005406 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 396595005407 Recombination protein O N terminal; Region: RecO_N; pfam11967 396595005408 Recombination protein O C terminal; Region: RecO_C; pfam02565 396595005409 GTPase Era; Reviewed; Region: era; PRK00089 396595005410 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 396595005411 G1 box; other site 396595005412 GTP/Mg2+ binding site [chemical binding]; other site 396595005413 Switch I region; other site 396595005414 G2 box; other site 396595005415 Switch II region; other site 396595005416 G3 box; other site 396595005417 G4 box; other site 396595005418 G5 box; other site 396595005419 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 396595005420 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 396595005421 dimerization interface [polypeptide binding]; other site 396595005422 active site 396595005423 metal binding site [ion binding]; metal-binding site 396595005424 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 396595005425 dsRNA binding site [nucleotide binding]; other site 396595005426 signal peptidase I; Provisional; Region: PRK10861 396595005427 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 396595005428 Catalytic site [active] 396595005429 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 396595005430 GTP-binding protein LepA; Provisional; Region: PRK05433 396595005431 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 396595005432 G1 box; other site 396595005433 putative GEF interaction site [polypeptide binding]; other site 396595005434 GTP/Mg2+ binding site [chemical binding]; other site 396595005435 Switch I region; other site 396595005436 G2 box; other site 396595005437 G3 box; other site 396595005438 Switch II region; other site 396595005439 G4 box; other site 396595005440 G5 box; other site 396595005441 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 396595005442 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 396595005443 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 396595005444 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 396595005445 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 396595005446 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 396595005447 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 396595005448 protein binding site [polypeptide binding]; other site 396595005449 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 396595005450 protein binding site [polypeptide binding]; other site 396595005451 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 396595005452 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 396595005453 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 396595005454 RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923 396595005455 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 396595005456 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 396595005457 DNA binding residues [nucleotide binding] 396595005458 L-aspartate oxidase; Provisional; Region: PRK09077 396595005459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595005460 domain; Region: Succ_DH_flav_C; pfam02910 396595005461 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 396595005462 FAD binding pocket [chemical binding]; other site 396595005463 conserved FAD binding motif [chemical binding]; other site 396595005464 phosphate binding motif [ion binding]; other site 396595005465 beta-alpha-beta structure motif; other site 396595005466 NAD binding pocket [chemical binding]; other site 396595005467 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 396595005468 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 396595005469 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 396595005470 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 396595005471 BolA-like protein; Region: BolA; cl00386 396595005472 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 396595005473 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 396595005474 lipoyl synthase; Provisional; Region: PRK05481 396595005475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 396595005476 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 396595005477 Protein of unknown function (DUF493); Region: DUF493; cl01102 396595005478 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558 396595005479 homodimer interface [polypeptide binding]; other site 396595005480 substrate-cofactor binding pocket; other site 396595005481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 396595005482 Aminotransferase class IV; Region: Aminotran_4; pfam01063 396595005483 catalytic residue [active] 396595005484 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 396595005485 Beta-lactamase; Region: Beta-lactamase; cl01009 396595005486 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 396595005487 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 396595005488 Sporulation related domain; Region: SPOR; cl10051 396595005489 lytic murein transglycosylase; Region: MltB_2; TIGR02283 396595005490 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 396595005491 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 396595005492 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 396595005493 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 396595005494 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 396595005495 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 396595005496 dimer interface [polypeptide binding]; other site 396595005497 substrate binding site [chemical binding]; other site 396595005498 metal binding sites [ion binding]; metal-binding site 396595005499 adenylate kinase; Reviewed; Region: adk; PRK00279 396595005500 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 396595005501 AMP-binding site [chemical binding]; other site 396595005502 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 396595005503 organic solvent tolerance protein; Provisional; Region: PRK04423 396595005504 Organic solvent tolerance protein; Region: OstA_C; pfam04453 396595005505 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 396595005506 SurA N-terminal domain; Region: SurA_N; pfam09312 396595005507 PPIC-type PPIASE domain; Region: Rotamase; cl08278 396595005508 PPIC-type PPIASE domain; Region: Rotamase; cl08278 396595005509 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 396595005510 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 396595005511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595005512 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 396595005513 Protein of unknown function (DUF525); Region: DUF525; cl01119 396595005514 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 396595005515 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 396595005516 active site 396595005517 metal binding site [ion binding]; metal-binding site 396595005518 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 396595005519 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 396595005520 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 396595005521 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 396595005522 Predicted amidohydrolase [General function prediction only]; Region: COG0388 396595005523 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 396595005524 putative active site [active] 396595005525 catalytic triad [active] 396595005526 dimer interface [polypeptide binding]; other site 396595005527 TIGR02099 family protein; Region: TIGR02099 396595005528 ribonuclease G; Provisional; Region: PRK11712 396595005529 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 396595005530 homodimer interface [polypeptide binding]; other site 396595005531 oligonucleotide binding site [chemical binding]; other site 396595005532 Domain of unknown function DUF20; Region: UPF0118; cl00465 396595005533 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 396595005534 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 396595005535 conserved cys residue [active] 396595005536 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 396595005537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595005538 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 396595005539 putative dimerization interface [polypeptide binding]; other site 396595005540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595005541 metal binding site [ion binding]; metal-binding site 396595005542 active site 396595005543 I-site; other site 396595005544 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595005545 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 396595005546 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 396595005547 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 396595005548 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595005549 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 396595005550 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 396595005551 homotrimer interaction site [polypeptide binding]; other site 396595005552 putative active site [active] 396595005553 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 396595005554 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 396595005555 DNA binding site [nucleotide binding] 396595005556 catalytic residue [active] 396595005557 H2TH interface [polypeptide binding]; other site 396595005558 putative catalytic residues [active] 396595005559 turnover-facilitating residue; other site 396595005560 intercalation triad [nucleotide binding]; other site 396595005561 8OG recognition residue [nucleotide binding]; other site 396595005562 putative reading head residues; other site 396595005563 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 396595005564 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 396595005565 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 396595005566 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 396595005567 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 396595005568 synthetase active site [active] 396595005569 NTP binding site [chemical binding]; other site 396595005570 metal binding site [ion binding]; metal-binding site 396595005571 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 396595005572 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 396595005573 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 396595005574 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 396595005575 catalytic site [active] 396595005576 G-X2-G-X-G-K; other site 396595005577 octaprenyl diphosphate synthase; Provisional; Region: PRK10888 396595005578 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 396595005579 substrate binding pocket [chemical binding]; other site 396595005580 chain length determination region; other site 396595005581 substrate-Mg2+ binding site; other site 396595005582 catalytic residues [active] 396595005583 aspartate-rich region 1; other site 396595005584 active site lid residues [active] 396595005585 aspartate-rich region 2; other site 396595005586 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 396595005587 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 396595005588 GTPase CgtA; Reviewed; Region: obgE; PRK12299 396595005589 GTP1/OBG; Region: GTP1_OBG; pfam01018 396595005590 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 396595005591 G1 box; other site 396595005592 GTP/Mg2+ binding site [chemical binding]; other site 396595005593 Switch I region; other site 396595005594 G2 box; other site 396595005595 G3 box; other site 396595005596 Switch II region; other site 396595005597 G4 box; other site 396595005598 G5 box; other site 396595005599 gamma-glutamyl kinase; Provisional; Region: PRK05429 396595005600 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 396595005601 nucleotide binding site [chemical binding]; other site 396595005602 homotetrameric interface [polypeptide binding]; other site 396595005603 putative phosphate binding site [ion binding]; other site 396595005604 putative allosteric binding site; other site 396595005605 PUA domain; Region: PUA; cl00607 396595005606 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 396595005607 homotrimer interaction site [polypeptide binding]; other site 396595005608 putative active site [active] 396595005609 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 396595005610 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 396595005611 ssDNA binding site; other site 396595005612 generic binding surface II; other site 396595005613 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 396595005614 ATP binding site [chemical binding]; other site 396595005615 putative Mg++ binding site [ion binding]; other site 396595005616 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 396595005617 nucleotide binding region [chemical binding]; other site 396595005618 ATP-binding site [chemical binding]; other site 396595005619 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 396595005620 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 396595005621 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 396595005622 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 396595005623 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 396595005624 RuvA N terminal domain; Region: RuvA_N; pfam01330 396595005625 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 396595005626 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 396595005627 active site 396595005628 putative DNA-binding cleft [nucleotide binding]; other site 396595005629 dimer interface [polypeptide binding]; other site 396595005630 Domain of unknown function DUF28; Region: DUF28; cl00361 396595005631 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 396595005632 conserved cys residue [active] 396595005633 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 396595005634 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 396595005635 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 396595005636 protein binding site [polypeptide binding]; other site 396595005637 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 396595005638 Catalytic dyad [active] 396595005639 Peptidase family M23; Region: Peptidase_M23; pfam01551 396595005640 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 396595005641 dimerization interface [polypeptide binding]; other site 396595005642 putative DNA binding site [nucleotide binding]; other site 396595005643 putative Zn2+ binding site [ion binding]; other site 396595005644 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 396595005645 active site residue [active] 396595005646 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 396595005647 GSH binding site [chemical binding]; other site 396595005648 catalytic residues [active] 396595005649 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 396595005650 SecA binding site; other site 396595005651 Preprotein binding site; other site 396595005652 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 396595005653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595005654 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 396595005655 TM2 domain; Region: TM2; cl00984 396595005656 BCCT family transporter; Region: BCCT; cl00569 396595005657 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl09206 396595005658 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 396595005659 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 396595005660 Clp amino terminal domain; Region: Clp_N; pfam02861 396595005661 Clp amino terminal domain; Region: Clp_N; pfam02861 396595005662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595005663 Walker A motif; other site 396595005664 ATP binding site [chemical binding]; other site 396595005665 Walker B motif; other site 396595005666 arginine finger; other site 396595005667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595005668 Walker A motif; other site 396595005669 ATP binding site [chemical binding]; other site 396595005670 Walker B motif; other site 396595005671 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 396595005672 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 396595005673 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 396595005674 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 396595005675 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 396595005676 RNA binding surface [nucleotide binding]; other site 396595005677 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 396595005678 active site 396595005679 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 396595005680 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595005681 binding surface 396595005682 TPR motif; other site 396595005683 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 396595005684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 396595005685 Transposase; Region: DEDD_Tnp_IS110; pfam01548 396595005686 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 396595005687 NAD synthetase; Provisional; Region: PRK13981 396595005688 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 396595005689 multimer interface [polypeptide binding]; other site 396595005690 active site 396595005691 catalytic triad [active] 396595005692 protein interface 1 [polypeptide binding]; other site 396595005693 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 396595005694 homodimer interface [polypeptide binding]; other site 396595005695 NAD binding pocket [chemical binding]; other site 396595005696 ATP binding pocket [chemical binding]; other site 396595005697 Mg binding site [ion binding]; other site 396595005698 active-site loop [active] 396595005699 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 396595005700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595005701 CoA-ligase; Region: Ligase_CoA; pfam00549 396595005702 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 396595005703 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 396595005704 CoA-ligase; Region: Ligase_CoA; pfam00549 396595005705 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 396595005706 tetramerization interface [polypeptide binding]; other site 396595005707 active site 396595005708 Pantoate-beta-alanine ligase; Region: PanC; cd00560 396595005709 active site 396595005710 ATP-binding site [chemical binding]; other site 396595005711 pantoate-binding site; other site 396595005712 HXXH motif; other site 396595005713 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 396595005714 oligomerization interface [polypeptide binding]; other site 396595005715 active site 396595005716 metal binding site [ion binding]; metal-binding site 396595005717 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 396595005718 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 396595005719 Substrate-binding site [chemical binding]; other site 396595005720 Substrate specificity [chemical binding]; other site 396595005721 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 396595005722 catalytic center binding site [active] 396595005723 ATP binding site [chemical binding]; other site 396595005724 poly(A) polymerase; Region: pcnB; TIGR01942 396595005725 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 396595005726 active site 396595005727 NTP binding site [chemical binding]; other site 396595005728 metal binding triad [ion binding]; metal-binding site 396595005729 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 396595005730 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 396595005731 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 396595005732 nudix motif; other site 396595005733 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 396595005734 RNA binding surface [nucleotide binding]; other site 396595005735 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 396595005736 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 396595005737 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 396595005738 N-terminal domain interface [polypeptide binding]; other site 396595005739 dimer interface [polypeptide binding]; other site 396595005740 substrate binding pocket (H-site) [chemical binding]; other site 396595005741 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 396595005742 metal binding site 2 [ion binding]; metal-binding site 396595005743 putative DNA binding helix; other site 396595005744 metal binding site 1 [ion binding]; metal-binding site 396595005745 dimer interface [polypeptide binding]; other site 396595005746 structural Zn2+ binding site [ion binding]; other site 396595005747 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 396595005748 Uncharacterised protein family (UPF0125); Region: UPF0125; cl01096 396595005749 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 396595005750 putative coenzyme Q binding site [chemical binding]; other site 396595005751 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 396595005752 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 396595005753 SmpB-tmRNA interface; other site 396595005754 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 396595005755 Domain of unknown function DUF20; Region: UPF0118; cl00465 396595005756 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 396595005757 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 396595005758 ATP binding site [chemical binding]; other site 396595005759 putative Mg++ binding site [ion binding]; other site 396595005760 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595005761 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 396595005762 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 396595005763 Outer membrane efflux protein; Region: OEP; pfam02321 396595005764 FtsX-like permease family; Region: FtsX; pfam02687 396595005765 FtsX-like permease family; Region: FtsX; pfam02687 396595005766 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 396595005767 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 396595005768 Walker A/P-loop; other site 396595005769 ATP binding site [chemical binding]; other site 396595005770 Q-loop/lid; other site 396595005771 ABC transporter signature motif; other site 396595005772 Walker B; other site 396595005773 D-loop; other site 396595005774 H-loop/switch region; other site 396595005775 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 396595005776 Transposase; Region: DEDD_Tnp_IS110; pfam01548 396595005777 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 396595005778 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 396595005779 substrate binding site [chemical binding]; other site 396595005780 ATP binding site [chemical binding]; other site 396595005781 Transposase; Region: DEDD_Tnp_IS110; pfam01548 396595005782 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 396595005783 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 396595005784 substrate binding site [chemical binding]; other site 396595005785 hypothetical protein; Provisional; Region: PRK10279 396595005786 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 396595005787 active site 396595005788 nucleophile elbow; other site 396595005789 Smr domain; Region: Smr; cl02619 396595005790 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 396595005791 Ligand Binding Site [chemical binding]; other site 396595005792 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 396595005793 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 396595005794 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 396595005795 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 396595005796 dimer interface [polypeptide binding]; other site 396595005797 active site 396595005798 heme binding site [chemical binding]; other site 396595005799 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 396595005800 Protein of unknown function (DUF3634); Region: DUF3634; pfam12321 396595005801 MarC family integral membrane protein; Region: MarC; cl00919 396595005802 Protein of unknown function (DUF3012); Region: DUF3012; pfam11216 396595005803 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 396595005804 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 396595005805 classical (c) SDRs; Region: SDR_c; cd05233 396595005806 NAD(P) binding site [chemical binding]; other site 396595005807 active site 396595005808 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 396595005809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595005810 LysR family transcriptional regulator; Provisional; Region: PRK14997 396595005811 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 396595005812 putative effector binding pocket; other site 396595005813 dimerization interface [polypeptide binding]; other site 396595005814 DoxX; Region: DoxX; cl00976 396595005815 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 396595005816 Pirin-related protein [General function prediction only]; Region: COG1741 396595005817 Cupin domain; Region: Cupin_2; cl09118 396595005818 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 396595005819 RES domain; Region: RES; cl02411 396595005820 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 396595005821 Peptidase family M48; Region: Peptidase_M48; cl12018 396595005822 Protein of unknown function (DUF3634); Region: DUF3634; pfam12321 396595005823 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 396595005824 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 396595005825 FMN binding site [chemical binding]; other site 396595005826 active site 396595005827 substrate binding site [chemical binding]; other site 396595005828 catalytic residue [active] 396595005829 Outer membrane efflux protein; Region: OEP; pfam02321 396595005830 Outer membrane efflux protein; Region: OEP; pfam02321 396595005831 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 396595005832 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 396595005833 Protein export membrane protein; Region: SecD_SecF; cl14618 396595005834 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 396595005835 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 396595005836 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 396595005837 anchoring element; other site 396595005838 dimer interface [polypeptide binding]; other site 396595005839 ATP binding site [chemical binding]; other site 396595005840 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 396595005841 active site 396595005842 metal binding site [ion binding]; metal-binding site 396595005843 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 396595005844 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 396595005845 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 396595005846 catalytic residues [active] 396595005847 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 396595005848 dimerization domain [polypeptide binding]; other site 396595005849 dimer interface [polypeptide binding]; other site 396595005850 catalytic residues [active] 396595005851 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 396595005852 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 396595005853 Int/Topo IB signature motif; other site 396595005854 active site 396595005855 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 396595005856 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 396595005857 dimer interface [polypeptide binding]; other site 396595005858 active site residues [active] 396595005859 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 396595005860 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 396595005861 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 396595005862 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 396595005863 GTP binding site [chemical binding]; other site 396595005864 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa...; Region: MobB; cd03116 396595005865 Walker A motif; other site 396595005866 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 396595005867 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 396595005868 dimer interface [polypeptide binding]; other site 396595005869 putative functional site; other site 396595005870 putative MPT binding site; other site 396595005871 PilZ domain; Region: PilZ; cl01260 396595005872 RDD family; Region: RDD; cl00746 396595005873 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 396595005874 active site 396595005875 catalytic triad [active] 396595005876 oxyanion hole [active] 396595005877 switch loop; other site 396595005878 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 396595005879 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 396595005880 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 396595005881 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 396595005882 multifunctional aminopeptidase A; Provisional; Region: PRK00913 396595005883 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 396595005884 interface (dimer of trimers) [polypeptide binding]; other site 396595005885 Substrate-binding/catalytic site; other site 396595005886 Zn-binding sites [ion binding]; other site 396595005887 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 396595005888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595005889 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 396595005890 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 396595005891 protein binding site [polypeptide binding]; other site 396595005892 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 396595005893 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 396595005894 active site 396595005895 dimer interface [polypeptide binding]; other site 396595005896 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 396595005897 dimer interface [polypeptide binding]; other site 396595005898 active site 396595005899 glycogen synthase; Provisional; Region: glgA; PRK00654 396595005900 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 396595005901 ADP-binding pocket [chemical binding]; other site 396595005902 homodimer interface [polypeptide binding]; other site 396595005903 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 396595005904 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 396595005905 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 396595005906 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 396595005907 dimer interface [polypeptide binding]; other site 396595005908 phosphorylation site [posttranslational modification] 396595005909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595005910 ATP binding site [chemical binding]; other site 396595005911 Mg2+ binding site [ion binding]; other site 396595005912 G-X-G motif; other site 396595005913 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 396595005914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595005915 active site 396595005916 phosphorylation site [posttranslational modification] 396595005917 intermolecular recognition site; other site 396595005918 dimerization interface [polypeptide binding]; other site 396595005919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595005920 Walker A motif; other site 396595005921 ATP binding site [chemical binding]; other site 396595005922 Walker B motif; other site 396595005923 arginine finger; other site 396595005924 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 396595005925 Maf-like protein; Region: Maf; pfam02545 396595005926 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 396595005927 active site 396595005928 dimer interface [polypeptide binding]; other site 396595005929 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 396595005930 Domain of unknown function DUF143; Region: DUF143; cl00519 396595005931 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 396595005932 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 396595005933 active site 396595005934 (T/H)XGH motif; other site 396595005935 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 396595005936 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 396595005937 putative catalytic cysteine [active] 396595005938 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 396595005939 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 396595005940 Lipopolysaccharide-assembly; Region: LptE; cl01125 396595005941 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 396595005942 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 396595005943 HIGH motif; other site 396595005944 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 396595005945 active site 396595005946 KMSKS motif; other site 396595005947 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 396595005948 tRNA binding surface [nucleotide binding]; other site 396595005949 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 396595005950 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 396595005951 hypothetical protein; Provisional; Region: PRK11032 396595005952 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 396595005953 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 396595005954 putative active site [active] 396595005955 catalytic triad [active] 396595005956 putative dimer interface [polypeptide binding]; other site 396595005957 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 396595005958 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 396595005959 Transporter associated domain; Region: CorC_HlyC; cl08393 396595005960 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 396595005961 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 396595005962 PhoH-like protein; Region: PhoH; cl12134 396595005963 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 396595005964 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 396595005965 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 396595005966 FeS/SAM binding site; other site 396595005967 TRAM domain; Region: TRAM; cl01282 396595005968 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 396595005969 dimer interface [polypeptide binding]; other site 396595005970 ssDNA binding site [nucleotide binding]; other site 396595005971 tetramer (dimer of dimers) interface [polypeptide binding]; other site 396595005972 Major Facilitator Superfamily; Region: MFS_1; pfam07690 396595005973 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 396595005974 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 396595005975 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 396595005976 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 396595005977 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 396595005978 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 396595005979 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 396595005980 alphaNTD homodimer interface [polypeptide binding]; other site 396595005981 alphaNTD - beta interaction site [polypeptide binding]; other site 396595005982 alphaNTD - beta' interaction site [polypeptide binding]; other site 396595005983 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 396595005984 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 396595005985 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 396595005986 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 396595005987 RNA binding surface [nucleotide binding]; other site 396595005988 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 396595005989 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 396595005990 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 396595005991 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 396595005992 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 396595005993 SecY translocase; Region: SecY; pfam00344 396595005994 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 396595005995 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 396595005996 23S rRNA binding site [nucleotide binding]; other site 396595005997 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 396595005998 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 396595005999 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 396595006000 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 396595006001 5S rRNA interface [nucleotide binding]; other site 396595006002 23S rRNA interface [nucleotide binding]; other site 396595006003 L5 interface [polypeptide binding]; other site 396595006004 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 396595006005 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 396595006006 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 396595006007 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 396595006008 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 396595006009 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 396595006010 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 396595006011 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 396595006012 KOW motif; Region: KOW; cl00354 396595006013 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 396595006014 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 396595006015 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 396595006016 23S rRNA interface [nucleotide binding]; other site 396595006017 putative translocon interaction site; other site 396595006018 signal recognition particle (SRP54) interaction site; other site 396595006019 L23 interface [polypeptide binding]; other site 396595006020 trigger factor interaction site; other site 396595006021 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 396595006022 23S rRNA interface [nucleotide binding]; other site 396595006023 5S rRNA interface [nucleotide binding]; other site 396595006024 putative antibiotic binding site [chemical binding]; other site 396595006025 L25 interface [polypeptide binding]; other site 396595006026 L27 interface [polypeptide binding]; other site 396595006027 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 396595006028 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 396595006029 G-X-X-G motif; other site 396595006030 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 396595006031 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 396595006032 protein-rRNA interface [nucleotide binding]; other site 396595006033 putative translocon binding site; other site 396595006034 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 396595006035 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 396595006036 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 396595006037 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 396595006038 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 396595006039 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 396595006040 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 396595006041 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 396595006042 elongation factor Tu; Reviewed; Region: PRK00049 396595006043 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 396595006044 G1 box; other site 396595006045 GEF interaction site [polypeptide binding]; other site 396595006046 GTP/Mg2+ binding site [chemical binding]; other site 396595006047 Switch I region; other site 396595006048 G2 box; other site 396595006049 G3 box; other site 396595006050 Switch II region; other site 396595006051 G4 box; other site 396595006052 G5 box; other site 396595006053 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 396595006054 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 396595006055 Antibiotic Binding Site [chemical binding]; other site 396595006056 elongation factor G; Reviewed; Region: PRK00007 396595006057 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 396595006058 G1 box; other site 396595006059 putative GEF interaction site [polypeptide binding]; other site 396595006060 GTP/Mg2+ binding site [chemical binding]; other site 396595006061 Switch I region; other site 396595006062 G2 box; other site 396595006063 G3 box; other site 396595006064 Switch II region; other site 396595006065 G4 box; other site 396595006066 G5 box; other site 396595006067 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 396595006068 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 396595006069 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 396595006070 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 396595006071 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 396595006072 S17 interaction site [polypeptide binding]; other site 396595006073 S8 interaction site; other site 396595006074 16S rRNA interaction site [nucleotide binding]; other site 396595006075 streptomycin interaction site [chemical binding]; other site 396595006076 23S rRNA interaction site [nucleotide binding]; other site 396595006077 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 396595006078 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 396595006079 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 396595006080 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 396595006081 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 396595006082 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 396595006083 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 396595006084 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 396595006085 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 396595006086 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 396595006087 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 396595006088 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 396595006089 DNA binding site [nucleotide binding] 396595006090 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 396595006091 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 396595006092 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 396595006093 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 396595006094 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 396595006095 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 396595006096 RPB11 interaction site [polypeptide binding]; other site 396595006097 RPB12 interaction site [polypeptide binding]; other site 396595006098 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 396595006099 RPB3 interaction site [polypeptide binding]; other site 396595006100 RPB1 interaction site [polypeptide binding]; other site 396595006101 RPB11 interaction site [polypeptide binding]; other site 396595006102 RPB10 interaction site [polypeptide binding]; other site 396595006103 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 396595006104 peripheral dimer interface [polypeptide binding]; other site 396595006105 core dimer interface [polypeptide binding]; other site 396595006106 L10 interface [polypeptide binding]; other site 396595006107 L11 interface [polypeptide binding]; other site 396595006108 putative EF-Tu interaction site [polypeptide binding]; other site 396595006109 putative EF-G interaction site [polypeptide binding]; other site 396595006110 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 396595006111 23S rRNA interface [nucleotide binding]; other site 396595006112 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 396595006113 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 396595006114 mRNA/rRNA interface [nucleotide binding]; other site 396595006115 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 396595006116 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 396595006117 23S rRNA interface [nucleotide binding]; other site 396595006118 L7/L12 interface [polypeptide binding]; other site 396595006119 putative thiostrepton binding site; other site 396595006120 L25 interface [polypeptide binding]; other site 396595006121 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 396595006122 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 396595006123 putative homodimer interface [polypeptide binding]; other site 396595006124 KOW motif; Region: KOW; cl00354 396595006125 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 396595006126 elongation factor Tu; Reviewed; Region: PRK00049 396595006127 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 396595006128 G1 box; other site 396595006129 GEF interaction site [polypeptide binding]; other site 396595006130 GTP/Mg2+ binding site [chemical binding]; other site 396595006131 Switch I region; other site 396595006132 G2 box; other site 396595006133 G3 box; other site 396595006134 Switch II region; other site 396595006135 G4 box; other site 396595006136 G5 box; other site 396595006137 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 396595006138 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 396595006139 Antibiotic Binding Site [chemical binding]; other site 396595006140 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 396595006141 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 396595006142 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 396595006143 Walker A motif; other site 396595006144 ATP binding site [chemical binding]; other site 396595006145 Walker B motif; other site 396595006146 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 396595006147 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 396595006148 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 396595006149 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 396595006150 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 396595006151 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 396595006152 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 396595006153 CoA-binding site [chemical binding]; other site 396595006154 ATP-binding [chemical binding]; other site 396595006155 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 396595006156 hypothetical protein; Provisional; Region: PRK08999 396595006157 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 396595006158 active site 396595006159 8-oxo-dGMP binding site [chemical binding]; other site 396595006160 nudix motif; other site 396595006161 metal binding site [ion binding]; metal-binding site 396595006162 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 396595006163 active site 396595006164 thiamine phosphate binding site [chemical binding]; other site 396595006165 pyrophosphate binding site [ion binding]; other site 396595006166 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 396595006167 heterotetramer interface [polypeptide binding]; other site 396595006168 active site pocket [active] 396595006169 cleavage site 396595006170 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 396595006171 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 396595006172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 396595006173 nucleotide binding region [chemical binding]; other site 396595006174 ATP-binding site [chemical binding]; other site 396595006175 SEC-C motif; Region: SEC-C; cl12132 396595006176 Peptidase family M23; Region: Peptidase_M23; pfam01551 396595006177 Protein of unknown function (DUF721); Region: DUF721; cl02324 396595006178 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 396595006179 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 396595006180 cell division protein FtsZ; Validated; Region: PRK09330 396595006181 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 396595006182 nucleotide binding site [chemical binding]; other site 396595006183 SulA interaction site; other site 396595006184 cell division protein FtsA; Region: ftsA; TIGR01174 396595006185 Cell division protein FtsA; Region: FtsA; cl11496 396595006186 Cell division protein FtsA; Region: FtsA; cl11496 396595006187 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 396595006188 Cell division protein FtsQ; Region: FtsQ; pfam03799 396595006189 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 396595006190 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 396595006191 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 396595006192 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 396595006193 FAD binding domain; Region: FAD_binding_4; pfam01565 396595006194 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 396595006195 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 396595006196 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 396595006197 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 396595006198 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 396595006199 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 396595006200 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 396595006201 active site 396595006202 homodimer interface [polypeptide binding]; other site 396595006203 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 396595006204 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 396595006205 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 396595006206 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 396595006207 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 396595006208 Mg++ binding site [ion binding]; other site 396595006209 putative catalytic motif [active] 396595006210 putative substrate binding site [chemical binding]; other site 396595006211 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 396595006212 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 396595006213 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 396595006214 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 396595006215 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 396595006216 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 396595006217 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 396595006218 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 396595006219 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 396595006220 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 396595006221 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 396595006222 Septum formation initiator; Region: DivIC; cl11433 396595006223 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 396595006224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595006225 cell division protein MraZ; Reviewed; Region: PRK00326 396595006226 MraZ protein; Region: MraZ; pfam02381 396595006227 MraZ protein; Region: MraZ; pfam02381 396595006228 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 396595006229 Predicted methyltransferases [General function prediction only]; Region: COG0313 396595006230 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 396595006231 putative ligand binding site [chemical binding]; other site 396595006232 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 396595006233 FAD binding domain; Region: FAD_binding_4; pfam01565 396595006234 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 396595006235 Stringent starvation protein B; Region: SspB; cl01120 396595006236 stringent starvation protein A; Provisional; Region: sspA; PRK09481 396595006237 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 396595006238 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 396595006239 dimer interface [polypeptide binding]; other site 396595006240 N-terminal domain interface [polypeptide binding]; other site 396595006241 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 396595006242 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284 396595006243 Qi binding site; other site 396595006244 intrachain domain interface; other site 396595006245 interchain domain interface [polypeptide binding]; other site 396595006246 cytochrome b; Provisional; Region: CYTB; MTH00156 396595006247 heme bH binding site [chemical binding]; other site 396595006248 heme bL binding site [chemical binding]; other site 396595006249 Qo binding site; other site 396595006250 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cl00193 396595006251 interchain domain interface [polypeptide binding]; other site 396595006252 intrachain domain interface; other site 396595006253 Qi binding site; other site 396595006254 Qo binding site; other site 396595006255 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 396595006256 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 396595006257 [2Fe-2S] cluster binding site [ion binding]; other site 396595006258 Uncharacterized conserved protein [Function unknown]; Region: COG0327 396595006259 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 396595006260 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 396595006261 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 396595006262 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 396595006263 protein binding site [polypeptide binding]; other site 396595006264 Copper resistance protein CopC; Region: CopC; cl01012 396595006265 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 396595006266 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 396595006267 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 396595006268 Outer membrane efflux protein; Region: OEP; pfam02321 396595006269 Outer membrane efflux protein; Region: OEP; pfam02321 396595006270 aminopeptidase N; Provisional; Region: pepN; PRK14015 396595006271 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 396595006272 Zn binding site [ion binding]; other site 396595006273 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 396595006274 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 396595006275 active site 396595006276 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 396595006277 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 396595006278 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 396595006279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 396595006280 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 396595006281 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 396595006282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 396595006283 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 396595006284 RQC domain; Region: RQC; cl09632 396595006285 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 396595006286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 396595006287 motif II; other site 396595006288 BolA-like protein; Region: BolA; cl00386 396595006289 Sulfatase; Region: Sulfatase; cl10460 396595006290 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 396595006291 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 396595006292 ATP binding site [chemical binding]; other site 396595006293 putative Mg++ binding site [ion binding]; other site 396595006294 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 396595006295 nucleotide binding region [chemical binding]; other site 396595006296 ATP-binding site [chemical binding]; other site 396595006297 DEAD/H associated; Region: DEAD_assoc; pfam08494 396595006298 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 396595006299 active site 396595006300 trimer interface [polypeptide binding]; other site 396595006301 dimer interface [polypeptide binding]; other site 396595006302 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 396595006303 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 396595006304 carboxyltransferase (CT) interaction site; other site 396595006305 biotinylation site [posttranslational modification]; other site 396595006306 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 396595006307 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 396595006308 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 396595006309 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 396595006310 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 396595006311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595006312 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 396595006313 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 396595006314 FMN binding site [chemical binding]; other site 396595006315 active site 396595006316 catalytic residues [active] 396595006317 substrate binding site [chemical binding]; other site 396595006318 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 396595006319 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 396595006320 active site 396595006321 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; cl01820 396595006322 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 396595006323 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 396595006324 catalytic core [active] 396595006325 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 396595006326 amidase catalytic site [active] 396595006327 Zn binding residues [ion binding]; other site 396595006328 substrate binding site [chemical binding]; other site 396595006329 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 396595006330 catalytic residues [active] 396595006331 Entericidin EcnA/B family; Region: Entericidin; cl02322 396595006332 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 396595006333 UvrD/REP helicase; Region: UvrD-helicase; cl14126 396595006334 UvrD/REP helicase; Region: UvrD-helicase; cl14126 396595006335 potassium/proton antiporter; Reviewed; Region: PRK05326 396595006336 Transporter associated domain; Region: CorC_HlyC; cl08393 396595006337 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 396595006338 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 396595006339 Protein of unknown function (DUF502); Region: DUF502; cl01107 396595006340 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 396595006341 Flavoprotein; Region: Flavoprotein; cl08021 396595006342 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 396595006343 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 396595006344 trimer interface [polypeptide binding]; other site 396595006345 active site 396595006346 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 396595006347 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 396595006348 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 396595006349 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 396595006350 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 396595006351 putative DNA binding site [nucleotide binding]; other site 396595006352 catalytic residue [active] 396595006353 putative H2TH interface [polypeptide binding]; other site 396595006354 putative catalytic residues [active] 396595006355 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 396595006356 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 396595006357 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 396595006358 putative acyl-acceptor binding pocket; other site 396595006359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595006360 binding surface 396595006361 TPR motif; other site 396595006362 Cation transport protein; Region: TrkH; cl10514 396595006363 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 396595006364 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 396595006365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595006366 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 396595006367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595006368 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 396595006369 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 396595006370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595006371 active site 396595006372 phosphorylation site [posttranslational modification] 396595006373 intermolecular recognition site; other site 396595006374 dimerization interface [polypeptide binding]; other site 396595006375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595006376 Walker A motif; other site 396595006377 ATP binding site [chemical binding]; other site 396595006378 Walker B motif; other site 396595006379 arginine finger; other site 396595006380 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 396595006381 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 396595006382 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 396595006383 dimerization interface [polypeptide binding]; other site 396595006384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 396595006385 dimer interface [polypeptide binding]; other site 396595006386 phosphorylation site [posttranslational modification] 396595006387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595006388 ATP binding site [chemical binding]; other site 396595006389 Mg2+ binding site [ion binding]; other site 396595006390 G-X-G motif; other site 396595006391 16S rRNA methyltransferase B; Provisional; Region: PRK10901 396595006392 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 396595006393 putative RNA binding site [nucleotide binding]; other site 396595006394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595006395 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 396595006396 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 396595006397 putative active site [active] 396595006398 substrate binding site [chemical binding]; other site 396595006399 putative cosubstrate binding site; other site 396595006400 catalytic site [active] 396595006401 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 396595006402 substrate binding site [chemical binding]; other site 396595006403 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 396595006404 active site 396595006405 catalytic residues [active] 396595006406 metal binding site [ion binding]; metal-binding site 396595006407 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 396595006408 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 396595006409 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 396595006410 Protein of unknown function (DUF494); Region: DUF494; cl01103 396595006411 DNA topoisomerase I; Provisional; Region: PRK08780 396595006412 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 396595006413 active site 396595006414 interdomain interaction site; other site 396595006415 putative metal-binding site [ion binding]; other site 396595006416 nucleotide binding site [chemical binding]; other site 396595006417 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 396595006418 domain I; other site 396595006419 DNA binding groove [nucleotide binding] 396595006420 phosphate binding site [ion binding]; other site 396595006421 domain II; other site 396595006422 domain III; other site 396595006423 nucleotide binding site [chemical binding]; other site 396595006424 catalytic site [active] 396595006425 domain IV; other site 396595006426 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 396595006427 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 396595006428 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 396595006429 dimer interface [polypeptide binding]; other site 396595006430 allosteric magnesium binding site [ion binding]; other site 396595006431 active site 396595006432 aspartate-rich active site metal binding site; other site 396595006433 Schiff base residues; other site 396595006434 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 396595006435 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 396595006436 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 396595006437 shikimate binding site; other site 396595006438 NAD(P) binding site [chemical binding]; other site 396595006439 putative outer membrane lipoprotein; Provisional; Region: PRK10510 396595006440 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 396595006441 ligand binding site [chemical binding]; other site 396595006442 UbiA prenyltransferase family; Region: UbiA; cl00337 396595006443 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 396595006444 biotin synthase; Provisional; Region: PRK15108 396595006445 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 396595006446 FeS/SAM binding site; other site 396595006447 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 396595006448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595006449 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 396595006450 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 396595006451 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 396595006452 catalytic residue [active] 396595006453 Predicted membrane protein [Function unknown]; Region: COG2311 396595006454 Protein of unknown function (DUF418); Region: DUF418; cl12135 396595006455 hypothetical protein; Reviewed; Region: PRK00024 396595006456 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 396595006457 MPN+ (JAMM) motif; other site 396595006458 Zinc-binding site [ion binding]; other site 396595006459 Dehydratase family; Region: ILVD_EDD; cl00340 396595006460 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 396595006461 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 396595006462 N-acetylglutamate synthase; Validated; Region: PRK05279 396595006463 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an N-...; Region: AAK_NAGS-ABP; cd04237 396595006464 putative feedback inhibition sensing region; other site 396595006465 putative nucleotide binding site [chemical binding]; other site 396595006466 putative substrate binding site [chemical binding]; other site 396595006467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 396595006468 Coenzyme A binding pocket [chemical binding]; other site 396595006469 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 396595006470 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 396595006471 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 396595006472 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 396595006473 active site 396595006474 metal binding site [ion binding]; metal-binding site 396595006475 hexamer interface [polypeptide binding]; other site 396595006476 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 396595006477 Phosphotransferase enzyme family; Region: APH; pfam01636 396595006478 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 396595006479 Substrate binding site [chemical binding]; other site 396595006480 metal binding site [ion binding]; metal-binding site 396595006481 DsrE/DsrF-like family; Region: DrsE; cl00672 396595006482 DsrE/DsrF-like family; Region: DrsE; cl00672 396595006483 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 396595006484 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 396595006485 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 396595006486 DNA binding residues [nucleotide binding] 396595006487 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 396595006488 active site 396595006489 Zn-binding site [ion binding]; other site 396595006490 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 396595006491 dimer interface [polypeptide binding]; other site 396595006492 [2Fe-2S] cluster binding site [ion binding]; other site 396595006493 Protein of unknown function, DUF481; Region: DUF481; cl01213 396595006494 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 396595006495 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 396595006496 Cysteine-rich domain; Region: CCG; pfam02754 396595006497 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 396595006498 diiron binding motif [ion binding]; other site 396595006499 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 396595006500 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 396595006501 putative ADP-binding pocket [chemical binding]; other site 396595006502 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 396595006503 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 396595006504 active site 396595006505 motif I; other site 396595006506 motif II; other site 396595006507 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 396595006508 division inhibitor protein; Provisional; Region: slmA; PRK09480 396595006509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 396595006510 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 396595006511 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 396595006512 Outer membrane efflux protein; Region: OEP; pfam02321 396595006513 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 396595006514 Protein export membrane protein; Region: SecD_SecF; cl14618 396595006515 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 396595006516 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595006517 SelR domain; Region: SelR; cl00369 396595006518 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 396595006519 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 396595006520 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 396595006521 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 396595006522 putative dimer interface [polypeptide binding]; other site 396595006523 N-terminal domain interface [polypeptide binding]; other site 396595006524 putative substrate binding pocket (H-site) [chemical binding]; other site 396595006525 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099 396595006526 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 396595006527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 396595006528 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 396595006529 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 396595006530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595006531 S-adenosylmethionine binding site [chemical binding]; other site 396595006532 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 396595006533 heme-binding site [chemical binding]; other site 396595006534 Predicted membrane protein [Function unknown]; Region: COG4425 396595006535 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 396595006536 Surface antigen; Region: Surface_Ag_2; cl01155 396595006537 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 396595006538 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 396595006539 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 396595006540 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 396595006541 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595006542 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 396595006543 ABC transporter; Region: ABC_tran_2; pfam12848 396595006544 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 396595006545 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595006546 metal binding site [ion binding]; metal-binding site 396595006547 active site 396595006548 I-site; other site 396595006549 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 396595006550 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595006551 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 396595006552 dimerization interface [polypeptide binding]; other site 396595006553 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 396595006554 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637 396595006555 active site 396595006556 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 396595006557 cyclase homology domain; Region: CHD; cd07302 396595006558 nucleotidyl binding site; other site 396595006559 metal binding site [ion binding]; metal-binding site 396595006560 dimer interface [polypeptide binding]; other site 396595006561 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 396595006562 TraB family; Region: TraB; cl12050 396595006563 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 396595006564 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 396595006565 NAD(P) binding site [chemical binding]; other site 396595006566 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 396595006567 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 396595006568 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 396595006569 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 396595006570 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 396595006571 Response regulator receiver domain; Region: Response_reg; pfam00072 396595006572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595006573 active site 396595006574 phosphorylation site [posttranslational modification] 396595006575 intermolecular recognition site; other site 396595006576 dimerization interface [polypeptide binding]; other site 396595006577 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 396595006578 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cl03075 396595006579 Predicted amidohydrolase [General function prediction only]; Region: COG0388 396595006580 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 396595006581 putative active site [active] 396595006582 catalytic triad [active] 396595006583 putative dimer interface [polypeptide binding]; other site 396595006584 Bacterial membrane flanked domain; Region: DUF304; cl01348 396595006585 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 396595006586 OsmC-like protein; Region: OsmC; cl00767 396595006587 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 396595006588 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 396595006589 ligand binding site [chemical binding]; other site 396595006590 flexible hinge region; other site 396595006591 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 396595006592 putative switch regulator; other site 396595006593 non-specific DNA interactions [nucleotide binding]; other site 396595006594 DNA binding site [nucleotide binding] 396595006595 sequence specific DNA binding site [nucleotide binding]; other site 396595006596 putative cAMP binding site [chemical binding]; other site 396595006597 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 396595006598 active site 396595006599 ribulose/triose binding site [chemical binding]; other site 396595006600 phosphate binding site [ion binding]; other site 396595006601 substrate (anthranilate) binding pocket [chemical binding]; other site 396595006602 product (indole) binding pocket [chemical binding]; other site 396595006603 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 396595006604 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 396595006605 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 396595006606 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 396595006607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 396595006608 putative substrate translocation pore; other site 396595006609 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 396595006610 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 396595006611 glutamine binding [chemical binding]; other site 396595006612 catalytic triad [active] 396595006613 anthranilate synthase component I; Provisional; Region: PRK13565 396595006614 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 396595006615 chorismate binding enzyme; Region: Chorismate_bind; cl10555 396595006616 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 396595006617 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 396595006618 motif II; other site 396595006619 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 396595006620 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 396595006621 substrate binding site [chemical binding]; other site 396595006622 hexamer interface [polypeptide binding]; other site 396595006623 metal binding site [ion binding]; metal-binding site 396595006624 Cytochrome c; Region: Cytochrom_C; cl11414 396595006625 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 396595006626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595006627 S-adenosylmethionine binding site [chemical binding]; other site 396595006628 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 396595006629 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 396595006630 AIR carboxylase; Region: AIRC; cl00310 396595006631 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 396595006632 Phosphotransferase enzyme family; Region: APH; pfam01636 396595006633 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 396595006634 heme-binding site [chemical binding]; other site 396595006635 lytic murein transglycosylase; Provisional; Region: PRK11619 396595006636 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 396595006637 N-acetyl-D-glucosamine binding site [chemical binding]; other site 396595006638 catalytic residue [active] 396595006639 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 396595006640 active site 396595006641 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 396595006642 5'-3' exonuclease; Region: 53EXOc; smart00475 396595006643 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 396595006644 active site 396595006645 metal binding site 1 [ion binding]; metal-binding site 396595006646 putative 5' ssDNA interaction site; other site 396595006647 metal binding site 3; metal-binding site 396595006648 metal binding site 2 [ion binding]; metal-binding site 396595006649 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 396595006650 putative DNA binding site [nucleotide binding]; other site 396595006651 putative metal binding site [ion binding]; other site 396595006652 malate dehydrogenase; Reviewed; Region: PRK06223 396595006653 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 396595006654 NAD(P) binding site [chemical binding]; other site 396595006655 dimer interface [polypeptide binding]; other site 396595006656 tetramer (dimer of dimers) interface [polypeptide binding]; other site 396595006657 substrate binding site [chemical binding]; other site 396595006658 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 396595006659 Malic enzyme, N-terminal domain; Region: malic; pfam00390 396595006660 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 396595006661 putative NAD(P) binding site [chemical binding]; other site 396595006662 Peptidase family M48; Region: Peptidase_M48; cl12018 396595006663 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 396595006664 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 396595006665 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 396595006666 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 396595006667 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 396595006668 ATP binding site [chemical binding]; other site 396595006669 active site 396595006670 substrate binding site [chemical binding]; other site 396595006671 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 396595006672 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 396595006673 Family of unknown function (DUF500); Region: DUF500; cl01109 396595006674 hypothetical protein; Provisional; Region: PRK08185 396595006675 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 396595006676 intersubunit interface [polypeptide binding]; other site 396595006677 active site 396595006678 zinc binding site [ion binding]; other site 396595006679 Na+ binding site [ion binding]; other site 396595006680 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 396595006681 pyruvate kinase; Provisional; Region: PRK05826 396595006682 domain interfaces; other site 396595006683 active site 396595006684 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 396595006685 substrate binding site [chemical binding]; other site 396595006686 hinge regions; other site 396595006687 ADP binding site [chemical binding]; other site 396595006688 catalytic site [active] 396595006689 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 396595006690 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 396595006691 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 396595006692 transketolase; Reviewed; Region: PRK12753 396595006693 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 396595006694 TPP-binding site [chemical binding]; other site 396595006695 dimer interface [polypeptide binding]; other site 396595006696 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 396595006697 PYR/PP interface [polypeptide binding]; other site 396595006698 dimer interface [polypeptide binding]; other site 396595006699 TPP binding site [chemical binding]; other site 396595006700 S-adenosylmethionine synthetase; Validated; Region: PRK05250 396595006701 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 396595006702 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 396595006703 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 396595006704 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 396595006705 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401 396595006706 oligomerization interface [polypeptide binding]; other site 396595006707 active site 396595006708 NAD+ binding site [chemical binding]; other site 396595006709 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 396595006710 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 396595006711 FAD binding site [chemical binding]; other site 396595006712 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 396595006713 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 396595006714 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 396595006715 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 396595006716 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 396595006717 putative binding surface; other site 396595006718 active site 396595006719 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 396595006720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595006721 ATP binding site [chemical binding]; other site 396595006722 Mg2+ binding site [ion binding]; other site 396595006723 G-X-G motif; other site 396595006724 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 396595006725 Response regulator receiver domain; Region: Response_reg; pfam00072 396595006726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595006727 active site 396595006728 phosphorylation site [posttranslational modification] 396595006729 intermolecular recognition site; other site 396595006730 dimerization interface [polypeptide binding]; other site 396595006731 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 396595006732 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 396595006733 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 396595006734 Response regulator receiver domain; Region: Response_reg; pfam00072 396595006735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595006736 active site 396595006737 phosphorylation site [posttranslational modification] 396595006738 intermolecular recognition site; other site 396595006739 dimerization interface [polypeptide binding]; other site 396595006740 Response regulator receiver domain; Region: Response_reg; pfam00072 396595006741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595006742 active site 396595006743 phosphorylation site [posttranslational modification] 396595006744 intermolecular recognition site; other site 396595006745 dimerization interface [polypeptide binding]; other site 396595006746 glutathione synthetase; Provisional; Region: PRK05246 396595006747 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 396595006748 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 396595006749 ApbE family; Region: ApbE; cl00643 396595006750 NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910 396595006751 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 396595006752 Gram-negative bacterial tonB protein; Region: TonB; cl10048 396595006753 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 396595006754 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 396595006755 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 396595006756 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 396595006757 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 396595006758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595006759 dihydroorotase; Validated; Region: pyrC; PRK09357 396595006760 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 396595006761 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 396595006762 active site 396595006763 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 396595006764 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 396595006765 FAD binding pocket [chemical binding]; other site 396595006766 FAD binding motif [chemical binding]; other site 396595006767 phosphate binding motif [ion binding]; other site 396595006768 beta-alpha-beta structure motif; other site 396595006769 NAD binding pocket [chemical binding]; other site 396595006770 Iron coordination center [ion binding]; other site 396595006771 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 396595006772 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595006773 Walker A motif; other site 396595006774 ATP binding site [chemical binding]; other site 396595006775 Walker B motif; other site 396595006776 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 396595006777 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595006778 Walker A motif; other site 396595006779 ATP binding site [chemical binding]; other site 396595006780 Walker B motif; other site 396595006781 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 396595006782 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 396595006783 Walker A motif; other site 396595006784 ATP binding site [chemical binding]; other site 396595006785 Walker B motif; other site 396595006786 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 396595006787 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 396595006788 catalytic residue [active] 396595006789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595006790 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 396595006791 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 396595006792 active site 396595006793 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 396595006794 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 396595006795 dimer interface [polypeptide binding]; other site 396595006796 ADP-ribose binding site [chemical binding]; other site 396595006797 active site 396595006798 nudix motif; other site 396595006799 metal binding site [ion binding]; metal-binding site 396595006800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 396595006801 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 396595006802 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 396595006803 Ligand Binding Site [chemical binding]; other site 396595006804 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 396595006805 putative metal binding site [ion binding]; other site 396595006806 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 396595006807 YGGT family; Region: YGGT; cl00508 396595006808 YGGT family; Region: YGGT; cl00508 396595006809 Domain of unknown function (DUF299); Region: DUF299; cl00780 396595006810 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 396595006811 phosphoenolpyruvate synthase; Validated; Region: PRK06464 396595006812 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 396595006813 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 396595006814 Protein of unknown function (DUF785); Region: DUF785; cl01682 396595006815 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 396595006816 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 396595006817 metal binding site 2 [ion binding]; metal-binding site 396595006818 putative DNA binding helix; other site 396595006819 metal binding site 1 [ion binding]; metal-binding site 396595006820 dimer interface [polypeptide binding]; other site 396595006821 structural Zn2+ binding site [ion binding]; other site 396595006822 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 396595006823 putative active site [active] 396595006824 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 396595006825 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 396595006826 intersubunit interface [polypeptide binding]; other site 396595006827 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 396595006828 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595006829 Walker A/P-loop; other site 396595006830 ATP binding site [chemical binding]; other site 396595006831 Q-loop/lid; other site 396595006832 ABC transporter signature motif; other site 396595006833 Walker B; other site 396595006834 D-loop; other site 396595006835 H-loop/switch region; other site 396595006836 Uncharacterized ACR, COG1469; Region: DUF198; cl00642 396595006837 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 396595006838 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 396595006839 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 396595006840 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 396595006841 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 396595006842 Predicted transcriptional regulator [Transcription]; Region: COG2378 396595006843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595006844 HIRAN domain; Region: HIRAN; cl07418 396595006845 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 396595006846 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595006847 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 396595006848 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 396595006849 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 396595006850 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 396595006851 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 396595006852 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 396595006853 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 396595006854 NAD(P) binding site [chemical binding]; other site 396595006855 catalytic residues [active] 396595006856 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 396595006857 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 396595006858 putative NAD(P) binding site [chemical binding]; other site 396595006859 active site 396595006860 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 396595006861 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 396595006862 active site 396595006863 NTP binding site [chemical binding]; other site 396595006864 metal binding triad [ion binding]; metal-binding site 396595006865 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 396595006866 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 396595006867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595006868 S-adenosylmethionine binding site [chemical binding]; other site 396595006869 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 396595006870 Outer membrane efflux protein; Region: OEP; pfam02321 396595006871 Outer membrane efflux protein; Region: OEP; pfam02321 396595006872 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 396595006873 Isochorismatase family; Region: Isochorismatase; pfam00857 396595006874 catalytic triad [active] 396595006875 dimer interface [polypeptide binding]; other site 396595006876 conserved cis-peptide bond; other site 396595006877 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 396595006878 proposed active site lysine [active] 396595006879 conserved cys residue [active] 396595006880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595006881 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 396595006882 ThiS interaction site; other site 396595006883 putative active site [active] 396595006884 tetramer interface [polypeptide binding]; other site 396595006885 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 396595006886 thiS-thiF/thiG interaction site; other site 396595006887 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 396595006888 metal binding site 2 [ion binding]; metal-binding site 396595006889 putative DNA binding helix; other site 396595006890 metal binding site 1 [ion binding]; metal-binding site 396595006891 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 396595006892 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 396595006893 ATP binding site [chemical binding]; other site 396595006894 Mg++ binding site [ion binding]; other site 396595006895 motif III; other site 396595006896 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 396595006897 nucleotide binding region [chemical binding]; other site 396595006898 ATP-binding site [chemical binding]; other site 396595006899 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 396595006900 catalytic residues [active] 396595006901 transcription termination factor Rho; Provisional; Region: rho; PRK09376 396595006902 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 396595006903 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 396595006904 RNA binding site [nucleotide binding]; other site 396595006905 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 396595006906 multimer interface [polypeptide binding]; other site 396595006907 Walker A motif; other site 396595006908 ATP binding site [chemical binding]; other site 396595006909 Walker B motif; other site 396595006910 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 396595006911 HemN family oxidoreductase; Provisional; Region: PRK05660 396595006912 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 396595006913 FeS/SAM binding site; other site 396595006914 HemN C-terminal region; Region: HemN_C; pfam06969 396595006915 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 396595006916 active site 396595006917 dimerization interface [polypeptide binding]; other site 396595006918 ribonuclease PH; Reviewed; Region: rph; PRK00173 396595006919 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 396595006920 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 396595006921 hypothetical protein; Provisional; Region: PRK11820 396595006922 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 396595006923 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 396595006924 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 396595006925 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 396595006926 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 396595006927 putative dimer interface [polypeptide binding]; other site 396595006928 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 396595006929 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 396595006930 HSP70 interaction site [polypeptide binding]; other site 396595006931 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 396595006932 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 396595006933 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 396595006934 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 396595006935 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 396595006936 protein binding site [polypeptide binding]; other site 396595006937 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 396595006938 protein binding site [polypeptide binding]; other site 396595006939 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 396595006940 MoaE homodimer interface [polypeptide binding]; other site 396595006941 MoaD interaction [polypeptide binding]; other site 396595006942 active site residues [active] 396595006943 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 396595006944 MoaE interaction surface [polypeptide binding]; other site 396595006945 MoeB interaction surface [polypeptide binding]; other site 396595006946 thiocarboxylated glycine; other site 396595006947 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 396595006948 trimer interface [polypeptide binding]; other site 396595006949 dimer interface [polypeptide binding]; other site 396595006950 putative active site [active] 396595006951 AsmA family; Region: AsmA; pfam05170 396595006952 adenine DNA glycosylase; Provisional; Region: PRK10880 396595006953 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 396595006954 minor groove reading motif; other site 396595006955 helix-hairpin-helix signature motif; other site 396595006956 substrate binding pocket [chemical binding]; other site 396595006957 active site 396595006958 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 396595006959 nudix motif; other site 396595006960 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 396595006961 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 396595006962 active site 396595006963 catalytic residues [active] 396595006964 metal binding site [ion binding]; metal-binding site 396595006965 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 396595006966 hydrophobic ligand binding site; other site 396595006967 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 396595006968 putative active site [active] 396595006969 putative NTP binding site [chemical binding]; other site 396595006970 putative nucleic acid binding site [nucleotide binding]; other site 396595006971 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 396595006972 active site 396595006973 8-oxo-dGMP binding site [chemical binding]; other site 396595006974 nudix motif; other site 396595006975 metal binding site [ion binding]; metal-binding site 396595006976 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 396595006977 putative homodimer interface [polypeptide binding]; other site 396595006978 putative active site [active] 396595006979 catalytic site [active] 396595006980 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 396595006981 ATP binding site [chemical binding]; other site 396595006982 putative Mg++ binding site [ion binding]; other site 396595006983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 396595006984 nucleotide binding region [chemical binding]; other site 396595006985 ATP-binding site [chemical binding]; other site 396595006986 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 396595006987 UDP-glucose-4-epimerase; Region: galE; TIGR01179 396595006988 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 396595006989 NAD binding site [chemical binding]; other site 396595006990 homodimer interface [polypeptide binding]; other site 396595006991 active site 396595006992 substrate binding site [chemical binding]; other site 396595006993 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 396595006994 putative active site [active] 396595006995 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 396595006996 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 396595006997 Bacterial sugar transferase; Region: Bac_transf; cl00939 396595006998 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 396595006999 GAF domain; Region: GAF; cl00853 396595007000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595007001 ATP binding site [chemical binding]; other site 396595007002 Mg2+ binding site [ion binding]; other site 396595007003 G-X-G motif; other site 396595007004 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 396595007005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595007006 active site 396595007007 phosphorylation site [posttranslational modification] 396595007008 intermolecular recognition site; other site 396595007009 dimerization interface [polypeptide binding]; other site 396595007010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595007011 Walker A motif; other site 396595007012 ATP binding site [chemical binding]; other site 396595007013 Walker B motif; other site 396595007014 arginine finger; other site 396595007015 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 396595007016 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 396595007017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595007018 TPR motif; other site 396595007019 binding surface 396595007020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595007021 binding surface 396595007022 TPR motif; other site 396595007023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595007024 binding surface 396595007025 TPR motif; other site 396595007026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595007027 TPR motif; other site 396595007028 binding surface 396595007029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595007030 binding surface 396595007031 TPR motif; other site 396595007032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595007033 binding surface 396595007034 TPR motif; other site 396595007035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595007036 binding surface 396595007037 TPR motif; other site 396595007038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595007039 TPR motif; other site 396595007040 binding surface 396595007041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 396595007042 TPR motif; other site 396595007043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595007044 S-adenosylmethionine binding site [chemical binding]; other site 396595007045 hypothetical protein; Validated; Region: PRK08223 396595007046 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 396595007047 ATP binding site [chemical binding]; other site 396595007048 substrate interface [chemical binding]; other site 396595007049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 396595007050 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 396595007051 PilZ domain; Region: PilZ; cl01260 396595007052 Chain length determinant protein; Region: Wzz; cl01623 396595007053 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 396595007054 exopolysaccharide/PEPCTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 396595007055 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 396595007056 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 396595007057 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595007058 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 396595007059 polysaccharide deactylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 396595007060 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 396595007061 Domain of unknown function (DUF3473); Region: DUF3473; pfam11959 396595007062 FemAB family; Region: FemAB; cl11444 396595007063 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 396595007064 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 396595007065 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 396595007066 eight transmembrane protein EpsH (proposed exosortase); Region: 8TM_EpsH; cl10495 396595007067 Protein of unknown function (DUF3485); Region: DUF3485; cl11827 396595007068 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 396595007069 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 396595007070 putative ADP-binding pocket [chemical binding]; other site 396595007071 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 396595007072 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 396595007073 active site 396595007074 dimer interface [polypeptide binding]; other site 396595007075 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 396595007076 Ligand Binding Site [chemical binding]; other site 396595007077 Molecular Tunnel; other site 396595007078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595007079 PEP-CTERM/exosortase 1-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 396595007080 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 396595007081 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (; Region: GT1_wlbH_like; cd03798 396595007082 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 396595007083 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 396595007084 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 396595007085 Ligand Binding Site [chemical binding]; other site 396595007086 Molecular Tunnel; other site 396595007087 Phosphopantetheine attachment site; Region: PP-binding; cl09936 396595007088 hydrolase, ortholog 2, exosortase system type 1 associated; Region: hydr2_PEP; TIGR03101 396595007089 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 396595007090 hydrolase, ortholog 1, exosortase system type 1 associated; Region: hydr1_PEP; TIGR03100 396595007091 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 396595007092 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 396595007093 active site 396595007094 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 396595007095 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 396595007096 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 396595007097 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595007098 Walker A/P-loop; other site 396595007099 ATP binding site [chemical binding]; other site 396595007100 Q-loop/lid; other site 396595007101 ABC transporter signature motif; other site 396595007102 Walker B; other site 396595007103 D-loop; other site 396595007104 H-loop/switch region; other site 396595007105 pyridoxal-dependent decarboxylase, exosortase system type 1 associated; Region: dCO2ase_PEP1; TIGR03099 396595007106 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 396595007107 dimer interface [polypeptide binding]; other site 396595007108 active site 396595007109 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 396595007110 catalytic residues [active] 396595007111 substrate binding site [chemical binding]; other site 396595007112 acyl-CoA ligase (AMP-forming), exosortase system type 1 associated; Region: ligase_PEP_1; TIGR03098 396595007113 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 396595007114 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 396595007115 O-Antigen ligase; Region: Wzy_C; cl04850 396595007116 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 396595007117 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 396595007118 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 396595007119 Ligand Binding Site [chemical binding]; other site 396595007120 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 396595007121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 396595007122 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 396595007123 K+ potassium transporter; Region: K_trans; cl01227 396595007124 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 396595007125 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 396595007126 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 396595007127 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 396595007128 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 396595007129 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 396595007130 active site 396595007131 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 396595007132 homodimer interface [polypeptide binding]; other site 396595007133 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 396595007134 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 396595007135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595007136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595007137 S-adenosylmethionine binding site [chemical binding]; other site 396595007138 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 396595007139 Hpr binding site; other site 396595007140 active site 396595007141 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 396595007142 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 396595007143 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 396595007144 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 396595007145 putative active site [active] 396595007146 putative substrate binding site [chemical binding]; other site 396595007147 putative cosubstrate binding site; other site 396595007148 catalytic site [active] 396595007149 LytB protein; Region: LYTB; cl00507 396595007150 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 396595007151 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 396595007152 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 396595007153 lipoprotein signal peptidase; Provisional; Region: PRK14787 396595007154 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 396595007155 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 396595007156 active site 396595007157 HIGH motif; other site 396595007158 nucleotide binding site [chemical binding]; other site 396595007159 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 396595007160 active site 396595007161 KMSKS motif; other site 396595007162 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 396595007163 tRNA binding surface [nucleotide binding]; other site 396595007164 anticodon binding site; other site 396595007165 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 396595007166 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 396595007167 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 396595007168 active site 396595007169 Riboflavin kinase; Region: Flavokinase; cl03312 396595007170 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 396595007171 MatE; Region: MatE; cl10513 396595007172 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 396595007173 DNA-binding site [nucleotide binding]; DNA binding site 396595007174 RNA-binding motif; other site 396595007175 short chain dehydrogenase; Provisional; Region: PRK06924 396595007176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595007177 NAD(P) binding site [chemical binding]; other site 396595007178 active site 396595007179 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 396595007180 Putative ATPase (DUF699); Region: DUF699; pfam05127 396595007181 CHASE3 domain; Region: CHASE3; cl05000 396595007182 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 396595007183 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 396595007184 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 396595007185 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 396595007186 ABC transporter ATPase component; Reviewed; Region: PRK11147 396595007187 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 396595007188 Walker A/P-loop; other site 396595007189 ATP binding site [chemical binding]; other site 396595007190 Q-loop/lid; other site 396595007191 ABC transporter signature motif; other site 396595007192 Walker B; other site 396595007193 D-loop; other site 396595007194 H-loop/switch region; other site 396595007195 ABC transporter; Region: ABC_tran_2; pfam12848 396595007196 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 396595007197 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 396595007198 Ligand Binding Site [chemical binding]; other site 396595007199 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 396595007200 Ligand Binding Site [chemical binding]; other site 396595007201 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 396595007202 transmembrane helices; other site 396595007203 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 396595007204 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 396595007205 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 396595007206 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595007207 Active site [active] 396595007208 Uncharacterized conserved protein [Function unknown]; Region: COG3287 396595007209 FIST N domain; Region: FIST; cl10701 396595007210 FIST C domain; Region: FIST_C; pfam10442 396595007211 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 396595007212 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 396595007213 active site 396595007214 catalytic tetrad [active] 396595007215 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 396595007216 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 396595007217 active site 396595007218 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 396595007219 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755 396595007220 putative ATP binding site [chemical binding]; other site 396595007221 putative substrate interface [chemical binding]; other site 396595007222 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 396595007223 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 396595007224 putative acyl-acceptor binding pocket; other site 396595007225 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 396595007226 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 396595007227 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 396595007228 dimer interface [polypeptide binding]; other site 396595007229 motif 1; other site 396595007230 active site 396595007231 motif 2; other site 396595007232 motif 3; other site 396595007233 Cation efflux family; Region: Cation_efflux; cl00316 396595007234 glutamine synthetase; Provisional; Region: glnA; PRK09469 396595007235 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 396595007236 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 396595007237 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 396595007238 putative acyl-acceptor binding pocket; other site 396595007239 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 396595007240 Ligand Binding Site [chemical binding]; other site 396595007241 TIGR00269 family protein; Region: TIGR00269 396595007242 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 396595007243 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 396595007244 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 396595007245 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 396595007246 putative active site [active] 396595007247 dimerization interface [polypeptide binding]; other site 396595007248 putative tRNAtyr binding site [nucleotide binding]; other site 396595007249 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 396595007250 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 396595007251 glutaminase active site [active] 396595007252 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 396595007253 dimer interface [polypeptide binding]; other site 396595007254 active site 396595007255 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 396595007256 dimer interface [polypeptide binding]; other site 396595007257 active site 396595007258 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 396595007259 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 396595007260 Substrate binding site [chemical binding]; other site 396595007261 Mg++ binding site [ion binding]; other site 396595007262 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 396595007263 active site 396595007264 substrate binding site [chemical binding]; other site 396595007265 CoA binding site [chemical binding]; other site 396595007266 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 396595007267 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 396595007268 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 396595007269 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 396595007270 alpha subunit interaction interface [polypeptide binding]; other site 396595007271 Walker A motif; other site 396595007272 ATP binding site [chemical binding]; other site 396595007273 Walker B motif; other site 396595007274 inhibitor binding site; inhibition site 396595007275 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 396595007276 ATP synthase; Region: ATP-synt; cl00365 396595007277 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 396595007278 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 396595007279 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 396595007280 beta subunit interaction interface [polypeptide binding]; other site 396595007281 Walker A motif; other site 396595007282 ATP binding site [chemical binding]; other site 396595007283 Walker B motif; other site 396595007284 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 396595007285 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 396595007286 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 396595007287 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 396595007288 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 396595007289 ATP synthase subunit C; Region: ATP-synt_C; cl00466 396595007290 ATP synthase A chain; Region: ATP-synt_A; cl00413 396595007291 ParB-like nuclease domain; Region: ParBc; cl02129 396595007292 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 396595007293 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 396595007294 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 396595007295 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 396595007296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595007297 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 396595007298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 396595007299 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 396595007300 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 396595007301 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 396595007302 G1 box; other site 396595007303 GTP/Mg2+ binding site [chemical binding]; other site 396595007304 Switch I region; other site 396595007305 G2 box; other site 396595007306 Switch II region; other site 396595007307 G3 box; other site 396595007308 G4 box; other site 396595007309 G5 box; other site 396595007310 membrane protein insertase; Provisional; Region: PRK01318 396595007311 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 396595007312 Domain of unknown function DUF37; Region: DUF37; cl00506 396595007313 Ribonuclease P; Region: Ribonuclease_P; cl00457 396595007314 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 396595007315 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 396595007316 dimer interface [polypeptide binding]; other site 396595007317 ssDNA binding site [nucleotide binding]; other site 396595007318 tetramer (dimer of dimers) interface [polypeptide binding]; other site 396595007319 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 396595007320 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 396595007321 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 396595007322 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 396595007323 large tegument protein UL36; Provisional; Region: PHA03247 396595007324 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 396595007325 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 396595007326 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 396595007327 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 396595007328 Fe-S cluster binding site [ion binding]; other site 396595007329 active site 396595007330 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 396595007331 putative active site [active] 396595007332 putative catalytic site [active] 396595007333 putative Mg binding site IVb [ion binding]; other site 396595007334 putative phosphate binding site [ion binding]; other site 396595007335 putative DNA binding site [nucleotide binding]; other site 396595007336 putative Mg binding site IVa [ion binding]; other site 396595007337 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 396595007338 deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575 396595007339 deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575 396595007340 sensory histidine kinase AtoS; Provisional; Region: PRK11360 396595007341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 396595007342 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595007343 metal binding site [ion binding]; metal-binding site 396595007344 active site 396595007345 I-site; other site 396595007346 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 396595007347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 396595007348 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 396595007349 Probable transposase; Region: OrfB_IS605; pfam01385 396595007350 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 396595007351 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 396595007352 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 396595007353 nucleotide binding pocket [chemical binding]; other site 396595007354 K-X-D-G motif; other site 396595007355 catalytic site [active] 396595007356 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 396595007357 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cl00038 396595007358 CRISPR type AFERR-associated DEAD/DEAH-box helicase Csf4; Region: cas_csf4; TIGR03117 396595007359 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595007360 CRISPR/Cas system-associated protein Csf1; Region: Csf1_U; cl11863 396595007361 CRISPR/Cas system-associated RAMP superfamily protein Csf2; Region: Csf2_U; cl11864 396595007362 CRISPR/Cas system-associated RAMP superfamily protein Csf3; Region: Csf3_U; cl11865 396595007363 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 396595007364 UvrD/REP helicase; Region: UvrD-helicase; cl14126 396595007365 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 396595007366 Active Sites [active] 396595007367 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 396595007368 RES domain; Region: RES; cl02411 396595007369 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 396595007370 trimer interface [polypeptide binding]; other site 396595007371 active site 396595007372 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 396595007373 Active Sites [active] 396595007374 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 396595007375 structural tetrad; other site 396595007376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 396595007377 S-adenosylmethionine binding site [chemical binding]; other site 396595007378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595007379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595007380 DEAD-like helicases superfamily; Region: DEXDc; smart00487 396595007381 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595007382 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595007383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 396595007384 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 396595007385 Probable transposase; Region: OrfB_IS605; pfam01385 396595007386 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 396595007387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 396595007388 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 396595007389 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 396595007390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 396595007391 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 396595007392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 396595007393 cofactor binding site; other site 396595007394 DNA binding site [nucleotide binding] 396595007395 substrate interaction site [chemical binding]; other site 396595007396 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 396595007397 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 396595007398 active site 396595007399 catalytic residues [active] 396595007400 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 396595007401 metal binding triad [ion binding]; metal-binding site 396595007402 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 396595007403 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 396595007404 Hef nuclease; Provisional; Region: PRK13766 396595007405 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 396595007406 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 396595007407 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 396595007408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595007409 ATP binding site [chemical binding]; other site 396595007410 Mg2+ binding site [ion binding]; other site 396595007411 G-X-G motif; other site 396595007412 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 396595007413 anchoring element; other site 396595007414 dimer interface [polypeptide binding]; other site 396595007415 ATP binding site [chemical binding]; other site 396595007416 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 396595007417 active site 396595007418 metal binding site [ion binding]; metal-binding site 396595007419 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 396595007420 DNA gyrase subunit A; Validated; Region: PRK05560 396595007421 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 396595007422 CAP-like domain; other site 396595007423 Active site [active] 396595007424 primary dimer interface [polypeptide binding]; other site 396595007425 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 396595007426 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 396595007427 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 396595007428 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 396595007429 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 396595007430 dimerization domain [polypeptide binding]; other site 396595007431 dimer interface [polypeptide binding]; other site 396595007432 catalytic residues [active] 396595007433 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 396595007434 Initiator Replication protein; Region: Rep_3; cl03080 396595007435 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 396595007436 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 396595007437 P-loop; other site 396595007438 Magnesium ion binding site [ion binding]; other site 396595007439 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 396595007440 Magnesium ion binding site [ion binding]; other site 396595007441 ParB-like partition proteins; Region: parB_part; TIGR00180 396595007442 ParB-like nuclease domain; Region: ParBc; cl02129 396595007443 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 396595007444 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 396595007445 DNA binding site [nucleotide binding] 396595007446 Int/Topo IB signature motif; other site 396595007447 active site 396595007448 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 396595007449 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 396595007450 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cl00148 396595007451 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 396595007452 DNA-binding site [nucleotide binding]; DNA binding site 396595007453 RNA-binding motif; other site 396595007454 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 396595007455 dimer interface [polypeptide binding]; other site 396595007456 ssDNA binding site [nucleotide binding]; other site 396595007457 tetramer (dimer of dimers) interface [polypeptide binding]; other site 396595007458 Replication initiator protein A; Region: RPA; cl02339 396595007459 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595007460 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 396595007461 Catalytic site; other site 396595007462 UvrD/REP helicase; Region: UvrD-helicase; cl14126 396595007463 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 396595007464 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 396595007465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 396595007466 ATP binding site [chemical binding]; other site 396595007467 putative Mg++ binding site [ion binding]; other site 396595007468 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 396595007469 nucleotide binding region [chemical binding]; other site 396595007470 ATP-binding site [chemical binding]; other site 396595007471 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 396595007472 Tubulin-tyrosine ligase family; Region: TTL; pfam03133 396595007473 Restriction endonuclease; Region: Mrr_cat; cl00747 396595007474 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 396595007475 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 396595007476 putative acyl-acceptor binding pocket; other site 396595007477 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 396595007478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 396595007479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 396595007480 ATP binding site [chemical binding]; other site 396595007481 Mg2+ binding site [ion binding]; other site 396595007482 G-X-G motif; other site 396595007483 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 396595007484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 396595007485 active site 396595007486 phosphorylation site [posttranslational modification] 396595007487 intermolecular recognition site; other site 396595007488 dimerization interface [polypeptide binding]; other site 396595007489 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 396595007490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 396595007491 active site 396595007492 phosphorylation site [posttranslational modification] 396595007493 intermolecular recognition site; other site 396595007494 dimerization interface [polypeptide binding]; other site 396595007495 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 396595007496 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 396595007497 DHH family; Region: DHH; pfam01368 396595007498 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 396595007499 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 396595007500 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 396595007501 ATP binding site [chemical binding]; other site 396595007502 putative Mg++ binding site [ion binding]; other site 396595007503 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 396595007504 nucleotide binding region [chemical binding]; other site 396595007505 ATP-binding site [chemical binding]; other site 396595007506 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 396595007507 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 396595007508 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 396595007509 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 396595007510 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 396595007511 Walker A motif; other site 396595007512 hexamer interface [polypeptide binding]; other site 396595007513 ATP binding site [chemical binding]; other site 396595007514 Walker B motif; other site 396595007515 TrbC/VIRB2 family; Region: TrbC; cl01583 396595007516 TrbC/VIRB2 family; Region: TrbC; cl01583 396595007517 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 396595007518 VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 396595007519 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 396595007520 VirB8 protein; Region: VirB8; cl01500 396595007521 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 396595007522 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 396595007523 VirB7 interaction site; other site 396595007524 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 396595007525 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 396595007526 N-acetyl-D-glucosamine binding site [chemical binding]; other site 396595007527 catalytic residue [active] 396595007528 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 396595007529 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 396595007530 VirB7 interaction site; other site 396595007531 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 396595007532 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 396595007533 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 396595007534 Eukaryotic translation initiation factor 3 subunit 8 N-terminus; Region: eIF-3c_N; pfam05470 396595007535 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 396595007536 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 396595007537 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595007538 Walker A motif; other site 396595007539 ATP binding site [chemical binding]; other site 396595007540 Walker B motif; other site 396595007541 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 396595007542 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 396595007543 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 396595007544 Phage integrase family; Region: Phage_integrase; pfam00589 396595007545 DNA binding site [nucleotide binding] 396595007546 Int/Topo IB signature motif; other site 396595007547 active site 396595007548 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 396595007549 putative active site [active] 396595007550 cell division protein ZipA; Provisional; Region: PRK03427 396595007551 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 396595007552 Global regulator protein family; Region: CsrA; cl00670 396595007553 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 396595007554 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 396595007555 UvrD/REP helicase; Region: UvrD-helicase; cl14126 396595007556 UvrD/REP helicase; Region: UvrD-helicase; cl14126 396595007557 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 396595007558 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 396595007559 ligand binding site [chemical binding]; other site 396595007560 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 396595007561 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595007562 Walker A motif; other site 396595007563 ATP binding site [chemical binding]; other site 396595007564 Walker B motif; other site 396595007565 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 396595007566 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 396595007567 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 396595007568 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 396595007569 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 396595007570 Walker A motif; other site 396595007571 ATP binding site [chemical binding]; other site 396595007572 Walker B motif; other site 396595007573 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 396595007574 metal binding site [ion binding]; metal-binding site 396595007575 active site 396595007576 I-site; other site 396595007577 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 396595007578 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 396595007579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 396595007580 Walker A motif; other site 396595007581 ATP binding site [chemical binding]; other site 396595007582 Walker B motif; other site 396595007583 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 396595007584 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 396595007585 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 396595007586 metal ion-dependent adhesion site (MIDAS); other site 396595007587 conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760 396595007588 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 396595007589 structural tetrad; other site 396595007590 Whirly transcription factor; Region: Whirly; pfam08536 396595007591 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 396595007592 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 396595007593 P-loop; other site 396595007594 Magnesium ion binding site [ion binding]; other site 396595007595 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 396595007596 Magnesium ion binding site [ion binding]; other site 396595007597 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 396595007598 ParB-like nuclease domain; Region: ParBc; cl02129 396595007599 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 396595007600 dimer interface [polypeptide binding]; other site 396595007601 ssDNA binding site [nucleotide binding]; other site 396595007602 tetramer (dimer of dimers) interface [polypeptide binding]; other site 396595007603 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 396595007604 putative transposase OrfB; Reviewed; Region: PHA02517 396595007605 Integrase core domain; Region: rve; cl01316 396595007606 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470