-- dump date 20111121_015457 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_001933009.1 189025237 6333299 4..1398 1 NC_010741.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1398 dnaA 6333299 dnaA Treponema pallidum subsp. pallidum SS14 chromosomal replication initiation protein YP_001933009.1 4 D 455434 CDS YP_001933010.1 189025238 6333120 1641..2756 1 NC_010741.1 DNA-directed DNA polymerase beta subunit 2756 dnaN 6333120 dnaN Treponema pallidum subsp. pallidum SS14 DNA-directed DNA polymerase beta subunit YP_001933010.1 1641 D 455434 CDS YP_001933011.1 189025239 6333754 2623..3834 1 NC_010741.1 recombination protein RecF 3834 recF 6333754 recF Treponema pallidum subsp. pallidum SS14 recombination protein RecF YP_001933011.1 2623 D 455434 CDS YP_001933012.1 189025240 6333119 3827..4264 1 NC_010741.1 hypothetical protein 4264 6333119 TPASS_0004 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933012.1 3827 D 455434 CDS YP_001933013.1 189025241 6333755 4391..6832 1 NC_010741.1 DNA gyrase subunit A; DNA topoisomerase (ATP-hydrolyzing) subunit A 6832 gyrA 6333755 gyrA Treponema pallidum subsp. pallidum SS14 DNA topoisomerase (ATP-hydrolyzing) subunit A YP_001933013.1 4391 D 455434 CDS YP_001933014.1 189025242 6333118 7014..7967 1 NC_010741.1 protein Tp75 7967 6333118 TPASS_0006 Treponema pallidum subsp. pallidum SS14 protein Tp75 YP_001933014.1 7014 D 455434 CDS YP_001933015.1 189025243 6333121 7991..8260 1 NC_010741.1 hypothetical protein 8260 6333121 TPASS_0008 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933015.1 7991 D 455434 CDS YP_001933016.1 189025244 6332864 10237..10362 1 NC_010741.1 hypothetical protein 10362 6332864 TPASS_0010 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933016.1 10237 D 455434 CDS YP_001933017.1 189025245 6333131 10396..12378 1 NC_010741.1 protein TprB 12378 tprB 6333131 tprB Treponema pallidum subsp. pallidum SS14 protein TprB YP_001933017.1 10396 D 455434 CDS YP_001933018.1 189025246 6333144 12372..12545 1 NC_010741.1 hypothetical protein 12545 6333144 TPASS_0012 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933018.1 12372 D 455434 CDS YP_001933019.1 189025247 6333129 12542..13207 1 NC_010741.1 hypothetical protein 13207 6333129 TPASS_0013 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933019.1 12542 D 455434 CDS YP_001933020.1 189025248 6333761 13164..13772 1 NC_010741.1 hypothetical protein 13772 6333761 TPASS_0014 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933020.1 13164 D 455434 CDS YP_001933021.1 189025249 6333768 13963..15777 1 NC_010741.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit beta 15777 pheT 6333768 pheT Treponema pallidum subsp. pallidum SS14 phenylalanyl-tRNA synthetase subunit beta YP_001933021.1 13963 D 455434 CDS YP_001933022.1 189025250 6333130 15740..18313 1 NC_010741.1 ATP-dependent protease LA 18313 lon1 6333130 lon1 Treponema pallidum subsp. pallidum SS14 ATP-dependent protease LA YP_001933022.1 15740 D 455434 CDS YP_001933023.1 189025251 6333127 18401..19348 1 NC_010741.1 hypothetical protein 19348 6333127 TPASS_0017 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933023.1 18401 D 455434 CDS YP_001933024.1 189025252 6332852 19415..21388 1 NC_010741.1 transcription elongation factor 21388 6332852 TPASS_0018 Treponema pallidum subsp. pallidum SS14 transcription elongation factor YP_001933024.1 19415 D 455434 CDS YP_001933025.1 189025253 6333766 21555..22043 1 NC_010741.1 transcription elongation factor GreA 22043 greA 6333766 greA Treponema pallidum subsp. pallidum SS14 transcription elongation factor GreA YP_001933025.1 21555 D 455434 CDS YP_001933026.1 189025254 6333770 22043..24166 1 NC_010741.1 protein 76K 24166 6333770 TPASS_0020 Treponema pallidum subsp. pallidum SS14 protein 76K YP_001933026.1 22043 D 455434 CDS YP_001933027.1 189025255 6332872 25104..25370 1 NC_010741.1 hypothetical protein 25370 6332872 TPASS_0021 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933027.1 25104 D 455434 CDS YP_001933028.1 189025256 6333189 25325..27493 1 NC_010741.1 hypothetical protein 27493 6333189 TPASS_0022 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933028.1 25325 D 455434 CDS YP_001933029.1 189025257 6333184 27554..28885 1 NC_010741.1 sodium- and chloride- dependent transporter 28885 6333184 TPASS_0023 Treponema pallidum subsp. pallidum SS14 sodium- and chloride- dependent transporter YP_001933029.1 27554 D 455434 CDS YP_001933030.1 189025258 6333763 29065..29775 1 NC_010741.1 hypothetical protein 29775 6333763 TPASS_0024 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933030.1 29065 D 455434 CDS YP_001933031.1 189025259 6332893 complement(29854..32925) 1 NC_010741.1 hypothetical protein 32925 6332893 TPASS_0025 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933031.1 29854 R 455434 CDS YP_001933032.1 189025260 6332900 complement(32954..33976) 1 NC_010741.1 flagellar motor switch protein 33976 fliG1 6332900 fliG1 Treponema pallidum subsp. pallidum SS14 flagellar motor switch protein YP_001933032.1 32954 R 455434 CDS YP_001933033.1 189025261 6332891 34202..35425 1 NC_010741.1 hemolysin 35425 6332891 TPASS_0027 Treponema pallidum subsp. pallidum SS14 hemolysin YP_001933033.1 34202 D 455434 CDS YP_001933034.1 189025262 6333769 35439..36800 1 NC_010741.1 hemolysin 36800 6333769 TPASS_0028 Treponema pallidum subsp. pallidum SS14 hemolysin YP_001933034.1 35439 D 455434 CDS YP_001933035.1 189025263 6333742 36908..38185 1 NC_010741.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 38185 murA 6333742 murA Treponema pallidum subsp. pallidum SS14 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_001933035.1 36908 D 455434 CDS YP_001933036.1 189025264 6333183 38304..39938 1 NC_010741.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 39938 groEL 6333183 groEL Treponema pallidum subsp. pallidum SS14 chaperonin GroEL YP_001933036.1 38304 D 455434 CDS YP_001933037.1 189025265 6333177 40002..40280 1 NC_010741.1 hypothetical protein 40280 6333177 TPASS_0031 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933037.1 40002 D 455434 CDS YP_001933038.1 189025266 6332889 complement(40277..41077) 1 NC_010741.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 41077 6332889 TPASS_0032 Treponema pallidum subsp. pallidum SS14 16S ribosomal RNA methyltransferase RsmE YP_001933038.1 40277 R 455434 CDS YP_001933039.1 189025267 6333152 complement(41074..41685) 1 NC_010741.1 hypothetical protein 41685 6333152 TPASS_0033 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933039.1 41074 R 455434 CDS YP_001933040.1 189025268 6333179 complement(41786..42736) 1 NC_010741.1 ABC transporter, periplasmic binding protein 42736 6333179 TPASS_0034 Treponema pallidum subsp. pallidum SS14 ABC transporter, periplasmic binding protein YP_001933040.1 41786 R 455434 CDS YP_001933041.1 189025269 6333554 42934..43650 1 NC_010741.1 ABC transporter, ATP-binding protein 43650 6333554 TPASS_0035 Treponema pallidum subsp. pallidum SS14 ABC transporter, ATP-binding protein YP_001933041.1 42934 D 455434 CDS YP_001933042.1 189025270 6333115 43650..44450 1 NC_010741.1 ABC transporter, permease protein 44450 6333115 TPASS_0036 Treponema pallidum subsp. pallidum SS14 ABC transporter, permease protein YP_001933042.1 43650 D 455434 CDS YP_001933043.1 189025271 6333173 complement(44559..45554) 1 NC_010741.1 D-specific D-2-hydroxyacid dehydrogenase 45554 6333173 TPASS_0037 Treponema pallidum subsp. pallidum SS14 D-specific D-2-hydroxyacid dehydrogenase YP_001933043.1 44559 R 455434 CDS YP_001933044.1 189025272 6333176 complement(45651..46703) 1 NC_010741.1 regulatory protein PfoS/R 46703 pfoS/R 6333176 pfoS/R Treponema pallidum subsp. pallidum SS14 regulatory protein PfoS/R YP_001933044.1 45651 R 455434 CDS YP_001933045.1 189025273 6332888 46752..46910 1 NC_010741.1 hypothetical protein 46910 6332888 TPASS_0039 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933045.1 46752 D 455434 CDS YP_001933046.1 189025274 6333175 47588..49381 1 NC_010741.1 methyl-accepting chemotaxis protein 49381 mcp1 6333175 mcp1 Treponema pallidum subsp. pallidum SS14 methyl-accepting chemotaxis protein YP_001933046.1 47588 D 455434 CDS YP_001933047.1 189025275 6333169 49383..49505 1 NC_010741.1 hypothetical protein 49505 6333169 TPASS_0041 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933047.1 49383 D 455434 CDS YP_001933048.1 189025276 6333174 49502..50434 1 NC_010741.1 hypothetical protein 50434 6333174 TPASS_0042 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933048.1 49502 D 455434 CDS YP_001933049.1 189025277 6333170 50415..52547 1 NC_010741.1 soluble lytic transglycosylase 52547 6333170 TPASS_0043 Treponema pallidum subsp. pallidum SS14 soluble lytic transglycosylase YP_001933049.1 50415 D 455434 CDS YP_001933050.1 189025278 6333171 52587..54479 1 NC_010741.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 54479 gidA 6333171 gidA Treponema pallidum subsp. pallidum SS14 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA YP_001933050.1 52587 D 455434 CDS YP_001933051.1 189025279 6333165 complement(54535..55434) 1 NC_010741.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 55434 6333165 TPASS_0045 Treponema pallidum subsp. pallidum SS14 adenosine deaminase YP_001933051.1 54535 R 455434 CDS YP_001933052.1 189025280 6332886 complement(55796..56497) 1 NC_010741.1 hypothetical protein 56497 6332886 TPASS_0046 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933052.1 55796 R 455434 CDS YP_001933053.1 189025281 6333759 complement(56515..57036) 1 NC_010741.1 hypothetical protein 57036 6333759 TPASS_0047 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933053.1 56515 R 455434 CDS YP_001933054.1 189025282 6333172 complement(57042..57473) 1 NC_010741.1 hypothetical protein 57473 6333172 TPASS_0048 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933054.1 57042 R 455434 CDS YP_001933055.1 189025283 6332885 complement(57495..58523) 1 NC_010741.1 hypothetical protein 58523 6332885 TPASS_0049 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933055.1 57495 R 455434 CDS YP_001933056.1 189025284 6333168 complement(58816..59424) 1 NC_010741.1 hypothetical protein 59424 6333168 TPASS_0050 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933056.1 58816 R 455434 CDS YP_001933057.1 189025285 6333162 59575..60630 1 NC_010741.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 60630 prfA 6333162 prfA Treponema pallidum subsp. pallidum SS14 peptide chain release factor 1 YP_001933057.1 59575 D 455434 CDS YP_001933058.1 189025286 6333163 60600..61646 1 NC_010741.1 protoporphyrinogen oxidase 61646 hemK 6333163 hemK Treponema pallidum subsp. pallidum SS14 protoporphyrinogen oxidase YP_001933058.1 60600 D 455434 CDS YP_001933059.1 189025287 6333166 complement(61735..62790) 1 NC_010741.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 62790 nrdF 6333166 nrdF Treponema pallidum subsp. pallidum SS14 ribonucleotide-diphosphate reductase subunit beta YP_001933059.1 61735 R 455434 CDS YP_001933060.1 189025288 6333745 62961..63920 1 NC_010741.1 hypothetical protein 63920 6333745 TPASS_0054 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933060.1 62961 D 455434 CDS YP_001933061.1 189025289 6332884 64127..64363 1 NC_010741.1 hypothetical protein 64363 6332884 TPASS_0055 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933061.1 64127 D 455434 CDS YP_001933062.1 189025290 6332881 64360..66141 1 NC_010741.1 catalyzes the formation of oxaloacetate from pyruvate; pyruvate carboxylase subunit B 66141 oadA 6332881 oadA Treponema pallidum subsp. pallidum SS14 pyruvate carboxylase subunit B YP_001933062.1 64360 D 455434 CDS YP_001933063.1 189025291 6333757 66153..67562 1 NC_010741.1 oxaloacetate decarboxylase, subunit beta 67562 oadB 6333757 oadB Treponema pallidum subsp. pallidum SS14 oxaloacetate decarboxylase, subunit beta YP_001933063.1 66153 D 455434 CDS YP_001933064.1 189025292 6333161 complement(67637..68953) 1 NC_010741.1 replicative DNA helicase DnaB 68953 dnaB 6333161 dnaB Treponema pallidum subsp. pallidum SS14 replicative DNA helicase DnaB YP_001933064.1 67637 R 455434 CDS YP_001933065.1 189025293 6333167 complement(68937..69164) 1 NC_010741.1 hypothetical protein 69164 6333167 TPASS_0059 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933065.1 68937 R 455434 CDS YP_001933066.1 189025294 6333160 complement(69170..69640) 1 NC_010741.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 69640 rplI 6333160 rplI Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L9 YP_001933066.1 69170 R 455434 CDS YP_001933067.1 189025295 6333823 complement(69746..70045) 1 NC_010741.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 70045 rpsR 6333823 rpsR Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S18 YP_001933067.1 69746 R 455434 CDS YP_001933068.1 189025296 6333157 complement(70162..70692) 1 NC_010741.1 single-strand DNA binding protein Ssb 70692 ssb 6333157 ssb Treponema pallidum subsp. pallidum SS14 single-strand DNA binding protein Ssb YP_001933068.1 70162 R 455434 CDS YP_001933069.1 189025297 6333158 complement(70701..70982) 1 NC_010741.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 70982 rpsF 6333158 rpsF Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S6 YP_001933069.1 70701 R 455434 CDS YP_001933070.1 189025298 6332880 71124..71699 1 NC_010741.1 hypothetical protein 71699 6332880 TPASS_0064 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933070.1 71124 D 455434 CDS YP_001933071.1 189025299 6333159 71773..72360 1 NC_010741.1 hypothetical protein 72360 6333159 TPASS_0065 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933071.1 71773 D 455434 CDS YP_001933072.1 189025300 6333156 72344..72658 1 NC_010741.1 hypothetical protein 72658 6333156 TPASS_0066 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933072.1 72344 D 455434 CDS YP_001933073.1 189025301 6332879 72646..73827 1 NC_010741.1 hypothetical protein 73827 6332879 TPASS_0067 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933073.1 72646 D 455434 CDS YP_001933074.1 189025302 6333820 74008..75030 1 NC_010741.1 hypothetical protein 75030 6333820 TPASS_0068 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933074.1 74008 D 455434 CDS YP_001933075.1 189025303 6333154 complement(75086..75616) 1 NC_010741.1 hypothetical protein 75616 6333154 TPASS_0069 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933075.1 75086 R 455434 CDS YP_001933076.1 189025304 6333822 complement(75466..75852) 1 NC_010741.1 hypothetical protein 75852 6333822 TPASS_0070 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933076.1 75466 R 455434 CDS YP_001933077.1 189025305 6332878 complement(75903..78539) 1 NC_010741.1 ATP-dependent Clp protease, subunit B 78539 clpB 6332878 clpB Treponema pallidum subsp. pallidum SS14 ATP-dependent Clp protease, subunit B YP_001933077.1 75903 R 455434 CDS YP_001933078.1 189025306 6333819 78743..79015 1 NC_010741.1 hypothetical protein 79015 6333819 TPASS_0072 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933078.1 78743 D 455434 CDS YP_001933079.1 189025307 6333821 complement(79085..80626) 1 NC_010741.1 hypothetical protein 80626 6333821 TPASS_0073 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933079.1 79085 R 455434 CDS YP_001933080.1 189025308 6333180 80931..82340 1 NC_010741.1 sugar ABC transporter, periplasmic binding protein 82340 y4oP 6333180 y4oP Treponema pallidum subsp. pallidum SS14 sugar ABC transporter, periplasmic binding protein YP_001933080.1 80931 D 455434 CDS YP_001933081.1 189025309 6333153 82459..83349 1 NC_010741.1 sugar ABC transporter, permease protein 83349 y4oQ 6333153 y4oQ Treponema pallidum subsp. pallidum SS14 sugar ABC transporter, permease protein YP_001933081.1 82459 D 455434 CDS YP_001933082.1 189025310 6332877 83389..84210 1 NC_010741.1 sugar ABC transporter, permease protein 84210 y4oR 6332877 y4oR Treponema pallidum subsp. pallidum SS14 sugar ABC transporter, permease protein YP_001933082.1 83389 D 455434 CDS YP_001933083.1 189025311 6332876 84251..85867 1 NC_010741.1 capsular polysaccharide biosynthesis protein 85867 cap 6332876 cap Treponema pallidum subsp. pallidum SS14 capsular polysaccharide biosynthesis protein YP_001933083.1 84251 D 455434 CDS YP_001933084.1 189025312 6333818 85872..87110 1 NC_010741.1 spore coat polysaccharide biosynthesis protein 87110 spsC 6333818 spsC Treponema pallidum subsp. pallidum SS14 spore coat polysaccharide biosynthesis protein YP_001933084.1 85872 D 455434 CDS YP_001933085.1 189025313 6333203 87038..89260 1 NC_010741.1 hypothetical protein 89260 6333203 TPASS_0079 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933085.1 87038 D 455434 CDS YP_001933086.1 189025314 6333815 89257..89724 1 NC_010741.1 quinoline 2-oxidoreductase 89724 6333815 TPASS_0080 Treponema pallidum subsp. pallidum SS14 quinoline 2-oxidoreductase YP_001933086.1 89257 D 455434 CDS YP_001933087.1 189025315 6332890 89731..90579 1 NC_010741.1 hypothetical protein 90579 6332890 TPASS_0081 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933087.1 89731 D 455434 CDS YP_001933088.1 189025316 6333205 complement(90626..92428) 1 NC_010741.1 formate hydrogenlyase transcriptional activator FhlA 92428 fhlA 6333205 fhlA Treponema pallidum subsp. pallidum SS14 formate hydrogenlyase transcriptional activator FhlA YP_001933088.1 90626 R 455434 CDS YP_001933089.1 189025317 6333811 93174..94454 1 NC_010741.1 hypothetical protein 94454 6333811 TPASS_0083 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933089.1 93174 D 455434 CDS YP_001933090.1 189025318 6333817 complement(94434..94667) 1 NC_010741.1 hypothetical protein 94667 6333817 TPASS_0084 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933090.1 94434 R 455434 CDS YP_001933091.1 189025319 6333813 complement(94781..95227) 1 NC_010741.1 PTS system, nitrogen regulatory IIA component 95227 ptsN1 6333813 ptsN1 Treponema pallidum subsp. pallidum SS14 PTS system, nitrogen regulatory IIA component YP_001933091.1 94781 R 455434 CDS YP_001933092.1 189025320 6333164 95308..96252 1 NC_010741.1 hypothetical protein 96252 6333164 TPASS_0086 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933092.1 95308 D 455434 CDS YP_001933093.1 189025321 6333150 complement(96255..96794) 1 NC_010741.1 hypothetical protein 96794 6333150 TPASS_0087 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933093.1 96255 R 455434 CDS YP_001933094.1 189025322 6333814 complement(96778..97392) 1 NC_010741.1 hypothetical protein 97392 6333814 TPASS_0088 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933094.1 96778 R 455434 CDS YP_001933095.1 189025323 6333073 complement(97422..98657) 1 NC_010741.1 cyclic nucleotide binding protein 98657 6333073 TPASS_0089 Treponema pallidum subsp. pallidum SS14 cyclic nucleotide binding protein YP_001933095.1 97422 R 455434 CDS YP_001933096.1 189025324 6333812 complement(98740..99804) 1 NC_010741.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 99804 murB 6333812 murB Treponema pallidum subsp. pallidum SS14 UDP-N-acetylenolpyruvoylglucosamine reductase YP_001933096.1 98740 R 455434 CDS YP_001933097.1 189025325 6333805 99986..101548 1 NC_010741.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 101548 cysS 6333805 cysS Treponema pallidum subsp. pallidum SS14 cysteinyl-tRNA synthetase YP_001933097.1 99986 D 455434 CDS YP_001933098.1 189025326 6333791 101619..102107 1 NC_010741.1 RNA polymerase sigma-24 factor 102107 rpoE 6333791 rpoE Treponema pallidum subsp. pallidum SS14 RNA polymerase sigma-24 factor YP_001933098.1 101619 D 455434 CDS YP_001933099.1 189025327 6333807 102091..102738 1 NC_010741.1 hypothetical protein 102738 6333807 TPASS_0093 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933099.1 102091 D 455434 CDS YP_001933100.1 189025328 6333808 102876..103886 1 NC_010741.1 phosphate acetyltransferase 103886 pta 6333808 pta Treponema pallidum subsp. pallidum SS14 phosphate acetyltransferase YP_001933100.1 102876 D 455434 CDS YP_001933101.1 189025329 6332871 103886..105832 1 NC_010741.1 hypothetical protein 105832 6332871 TPASS_0095 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933101.1 103886 D 455434 CDS YP_001933102.1 189025330 6333806 complement(105906..106268) 1 NC_010741.1 dnaK suppressor 106268 6333806 TPASS_0096 Treponema pallidum subsp. pallidum SS14 dnaK suppressor YP_001933102.1 105906 R 455434 CDS YP_001933103.1 189025331 6333810 106438..106656 1 NC_010741.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 106656 infA 6333810 infA Treponema pallidum subsp. pallidum SS14 translation initiation factor IF-1 YP_001933103.1 106438 D 455434 CDS YP_001933104.1 189025332 6333149 complement(106716..107366) 1 NC_010741.1 heat-shock protein 107366 6333149 TPASS_0098 Treponema pallidum subsp. pallidum SS14 heat-shock protein YP_001933104.1 106716 R 455434 CDS YP_001933105.1 189025333 6333125 complement(107370..108125) 1 NC_010741.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 108125 pyrH 6333125 pyrH Treponema pallidum subsp. pallidum SS14 uridylate kinase YP_001933105.1 107370 R 455434 CDS YP_001933106.1 189025334 6333809 108320..108922 1 NC_010741.1 thioredoxin 108922 6333809 TPASS_0100 Treponema pallidum subsp. pallidum SS14 thioredoxin YP_001933106.1 108320 D 455434 CDS YP_001933107.1 189025335 6332873 108915..109709 1 NC_010741.1 cytochrome c biogenesis protein 109709 ccdA 6332873 ccdA Treponema pallidum subsp. pallidum SS14 cytochrome c biogenesis protein YP_001933107.1 108915 D 455434 CDS YP_001933108.1 189025336 6333802 complement(109747..111720) 1 NC_010741.1 Rep helicase, single-stranded DNA-dependent ATPase 111720 rep 6333802 rep Treponema pallidum subsp. pallidum SS14 Rep helicase, single-stranded DNA-dependent ATPase YP_001933108.1 109747 R 455434 CDS YP_001933109.1 189025337 6333803 111785..113608 1 NC_010741.1 ATP-dependent DNA helicase 113608 6333803 TPASS_0103 Treponema pallidum subsp. pallidum SS14 ATP-dependent DNA helicase YP_001933109.1 111785 D 455434 CDS YP_001933110.1 189025338 6333801 113855..115636 1 NC_010741.1 5'-nucleotidase 115636 ushA 6333801 ushA Treponema pallidum subsp. pallidum SS14 5'-nucleotidase YP_001933110.1 113855 D 455434 CDS YP_001933111.1 189025339 6333146 115803..118796 1 NC_010741.1 DNA polymerase I 118796 polA 6333146 polA Treponema pallidum subsp. pallidum SS14 DNA polymerase I YP_001933111.1 115803 D 455434 CDS YP_001933112.1 189025340 6333804 complement(118828..120360) 1 NC_010741.1 carnitine transporter 120360 6333804 TPASS_0106 Treponema pallidum subsp. pallidum SS14 carnitine transporter YP_001933112.1 118828 R 455434 CDS YP_001933113.1 189025341 6333148 complement(120341..121918) 1 NC_010741.1 protein LicC 121918 licC 6333148 licC Treponema pallidum subsp. pallidum SS14 protein LicC YP_001933113.1 120341 R 455434 CDS YP_001933114.1 189025342 6333147 complement(122272..123657) 1 NC_010741.1 catalyzes the formation of fructose 1,6-bisphosphate from fructose 6-phosphate and diphosphate; diphosphate--fructose-6-phosphate 1-phosphotransferase 123657 pfk 6333147 pfk Treponema pallidum subsp. pallidum SS14 diphosphate--fructose-6-phosphate 1-phosphotransferase YP_001933114.1 122272 R 455434 CDS YP_001933115.1 189025343 6333772 complement(123759..124637) 1 NC_010741.1 rRNA methylase 124637 6333772 TPASS_0109 Treponema pallidum subsp. pallidum SS14 rRNA methylase YP_001933115.1 123759 R 455434 CDS YP_001933116.1 189025344 6333793 125178..126911 1 NC_010741.1 hypothetical protein 126911 6333793 TPASS_0110 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933116.1 125178 D 455434 CDS YP_001933117.1 189025345 6332870 126971..128398 1 NC_010741.1 RNA polymerase sigma-54 factor 128398 rpoN 6332870 rpoN Treponema pallidum subsp. pallidum SS14 RNA polymerase sigma-54 factor YP_001933117.1 126971 D 455434 CDS YP_001933118.1 189025346 6332875 complement(128395..129747) 1 NC_010741.1 aminopeptidase C 129747 pepC 6332875 pepC Treponema pallidum subsp. pallidum SS14 aminopeptidase C YP_001933118.1 128395 R 455434 CDS YP_001933119.1 189025347 6333141 129889..130875 1 NC_010741.1 Lambda CII stability-governing protein 130875 hflK 6333141 hflK Treponema pallidum subsp. pallidum SS14 Lambda CII stability-governing protein YP_001933119.1 129889 D 455434 CDS YP_001933120.1 189025348 6332859 130880..131875 1 NC_010741.1 Lambda CII stability-governing protein 131875 hflC 6332859 hflC Treponema pallidum subsp. pallidum SS14 Lambda CII stability-governing protein YP_001933120.1 130880 D 455434 CDS YP_001933121.1 189025349 6332882 complement(131900..132709) 1 NC_010741.1 phosphomethypyrimidine kinase 132709 thiD 6332882 thiD Treponema pallidum subsp. pallidum SS14 phosphomethypyrimidine kinase YP_001933121.1 131900 R 455434 CDS YP_001933122.1 189025350 6333140 132860..134866 1 NC_010741.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 134866 uvrB 6333140 uvrB Treponema pallidum subsp. pallidum SS14 excinuclease ABC subunit B YP_001933122.1 132860 D 455434 CDS YP_001933123.1 189025351 6332868 complement(134898..136694) 1 NC_010741.1 protein TprC 136694 tprC 6332868 tprC Treponema pallidum subsp. pallidum SS14 protein TprC YP_001933123.1 134898 R 455434 CDS YP_001933124.1 189025352 6333788 complement(136774..138039) 1 NC_010741.1 hypothetical protein 138039 6333788 TPASS_0118 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933124.1 136774 R 455434 CDS YP_001933125.1 189025353 6333139 complement(138137..138796) 1 NC_010741.1 amino acid ABC transporter, permease protein 138796 yaeE 6333139 yaeE Treponema pallidum subsp. pallidum SS14 amino acid ABC transporter, permease protein YP_001933125.1 138137 R 455434 CDS YP_001933126.1 189025354 6332906 complement(138796..139605) 1 NC_010741.1 amino acid ABC transporter, ATP-binding protein 139605 6332906 TPASS_0120 Treponema pallidum subsp. pallidum SS14 amino acid ABC transporter, ATP-binding protein YP_001933126.1 138796 R 455434 CDS YP_001933127.1 189025355 6333137 139735..140802 1 NC_010741.1 hypothetical protein 140802 6333137 TPASS_0121 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933127.1 139735 D 455434 CDS YP_001933128.1 189025356 6333142 complement(141022..142878) 1 NC_010741.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase 142878 pckA 6333142 pckA Treponema pallidum subsp. pallidum SS14 phosphoenolpyruvate carboxykinase YP_001933128.1 141022 R 455434 CDS YP_001933129.1 189025357 6332867 142984..145554 1 NC_010741.1 hypothetical protein 145554 6332867 TPASS_0123 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933129.1 142984 D 455434 CDS YP_001933130.1 189025358 6333785 145568..146674 1 NC_010741.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 146674 6333785 TPASS_0124 Treponema pallidum subsp. pallidum SS14 GTP-dependent nucleic acid-binding protein EngD YP_001933130.1 145568 D 455434 CDS YP_001933131.1 189025359 6333135 146751..147545 1 NC_010741.1 exodeoxyribonuclease 147545 exoA 6333135 exoA Treponema pallidum subsp. pallidum SS14 exodeoxyribonuclease YP_001933131.1 146751 D 455434 CDS YP_001933132.1 189025360 6333787 complement(147609..148484) 1 NC_010741.1 hypothetical protein 148484 6333787 TPASS_0126 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933132.1 147609 R 455434 CDS YP_001933133.1 189025361 6333181 149847..150227 1 NC_010741.1 hypothetical protein 150227 6333181 TPASS_0127 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933133.1 149847 D 455434 CDS YP_001933134.1 189025362 6332902 150729..151076 1 NC_010741.1 hypothetical protein 151076 6332902 TPASS_0128 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933134.1 150729 D 455434 CDS YP_001933135.1 189025363 6333781 151061..151537 1 NC_010741.1 hypothetical protein 151537 6333781 TPASS_0129 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933135.1 151061 D 455434 CDS YP_001933136.1 189025364 6332866 complement(151866..152285) 1 NC_010741.1 hypothetical protein 152285 6332866 TPASS_0130 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933136.1 151866 R 455434 CDS YP_001933137.1 189025365 6333783 complement(152357..154153) 1 NC_010741.1 protein TprD 154153 tprD 6333783 tprD Treponema pallidum subsp. pallidum SS14 protein TprD YP_001933137.1 152357 R 455434 CDS YP_001933138.1 189025366 6333782 complement(154331..154408) 1 NC_010741.1 hypothetical protein 154408 6333782 TPASS_0132 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933138.1 154331 R 455434 CDS YP_001933139.1 189025367 6333784 complement(154393..155625) 1 NC_010741.1 hypothetical protein 155625 6333784 TPASS_0133 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933139.1 154393 R 455434 CDS YP_001933140.1 189025368 6333136 complement(155622..156752) 1 NC_010741.1 hypothetical protein 156752 6333136 TPASS_0134 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933140.1 155622 R 455434 CDS YP_001933141.1 189025369 6333778 complement(156704..157645) 1 NC_010741.1 hypothetical protein 157645 6333778 TPASS_0135 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933141.1 156704 R 455434 CDS YP_001933142.1 189025370 6333777 157985..159463 1 NC_010741.1 hypothetical protein 159463 6333777 TPASS_0136 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933142.1 157985 D 455434 CDS YP_001933143.1 189025371 6333780 159442..159579 1 NC_010741.1 hypothetical protein 159579 6333780 TPASS_0137 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933143.1 159442 D 455434 CDS YP_001933144.1 189025372 6333779 complement(159716..160453) 1 NC_010741.1 hypothetical protein 160453 6333779 TPASS_0138 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933144.1 159716 R 455434 CDS YP_001933145.1 189025373 6333134 complement(160461..161153) 1 NC_010741.1 hypothetical protein 161153 6333134 TPASS_0139 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933145.1 160461 R 455434 CDS YP_001933146.1 189025374 6333775 complement(161193..162920) 1 NC_010741.1 K+ transport protein 162920 ntpJ 6333775 ntpJ Treponema pallidum subsp. pallidum SS14 K+ transport protein YP_001933146.1 161193 R 455434 CDS YP_001933147.1 189025375 6333211 163092..163625 1 NC_010741.1 methylated-DNA-protein-cysteine S-methyltransferase 163625 dat 6333211 dat Treponema pallidum subsp. pallidum SS14 methylated-DNA-protein-cysteine S-methyltransferase YP_001933147.1 163092 D 455434 CDS YP_001933148.1 189025376 6333132 complement(163576..164238) 1 NC_010741.1 thiamine ABC transporter ATP-binding protein 164238 6333132 TPASS_0142 Treponema pallidum subsp. pallidum SS14 thiamine ABC transporter ATP-binding protein YP_001933148.1 163576 R 455434 CDS YP_001933149.1 189025377 6333145 complement(164231..166012) 1 NC_010741.1 thiamine ABC transporter permease 166012 6333145 TPASS_0143 Treponema pallidum subsp. pallidum SS14 thiamine ABC transporter permease YP_001933149.1 164231 R 455434 CDS YP_001933150.1 189025378 6333774 complement(165970..166977) 1 NC_010741.1 thiamine ABC transporter, thiamine-binding periplasmic protein 166977 6333774 TPASS_0144 Treponema pallidum subsp. pallidum SS14 thiamine ABC transporter, thiamine-binding periplasmic protein YP_001933150.1 165970 R 455434 CDS YP_001933151.1 189025379 6332894 167087..169057 1 NC_010741.1 long-chain-fatty-acid--CoA ligase 169057 6332894 TPASS_0145 Treponema pallidum subsp. pallidum SS14 long-chain-fatty-acid--CoA ligase YP_001933151.1 167087 D 455434 CDS YP_001933152.1 189025380 6333202 complement(170462..172321) 1 NC_010741.1 alpha-amylase 1 172321 6333202 TPASS_0147 Treponema pallidum subsp. pallidum SS14 alpha-amylase 1 YP_001933152.1 170462 R 455434 CDS YP_001933153.1 189025381 6333201 complement(172318..172896) 1 NC_010741.1 hypothetical protein 172896 6333201 TPASS_0148 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933153.1 172318 R 455434 CDS YP_001933154.1 189025382 6333200 complement(172890..173483) 1 NC_010741.1 hypothetical protein 173483 6333200 TPASS_0149 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933154.1 172890 R 455434 CDS YP_001933155.1 189025383 6332898 complement(173476..173943) 1 NC_010741.1 hypothetical protein 173943 6332898 TPASS_0150 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933155.1 173476 R 455434 CDS YP_001933156.1 189025384 6332899 complement(173927..174946) 1 NC_010741.1 hypothetical protein 174946 6332899 TPASS_0151 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933156.1 173927 R 455434 CDS YP_001933157.1 189025385 6333196 complement(174933..176477) 1 NC_010741.1 nitrogen fixation protein 176477 rnfC 6333196 rnfC Treponema pallidum subsp. pallidum SS14 nitrogen fixation protein YP_001933157.1 174933 R 455434 CDS YP_001933158.1 189025386 6333195 complement(176553..177044) 1 NC_010741.1 hypothetical protein 177044 6333195 TPASS_0153 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933158.1 176553 R 455434 CDS YP_001933159.1 189025387 6333194 177269..178306 1 NC_010741.1 hypothetical protein 178306 6333194 TPASS_0154 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933159.1 177269 D 455434 CDS YP_001933160.1 189025388 6333197 178312..179427 1 NC_010741.1 fibronectin binding protein 179427 6333197 TPASS_0155 Treponema pallidum subsp. pallidum SS14 fibronectin binding protein YP_001933160.1 178312 D 455434 CDS YP_001933161.1 189025389 6333198 complement(179468..179872) 1 NC_010741.1 hypothetical protein 179872 6333198 TPASS_0156 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933161.1 179468 R 455434 CDS YP_001933162.1 189025390 6333190 complement(179869..180771) 1 NC_010741.1 hypothetical protein 180771 6333190 TPASS_0157 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933162.1 179869 R 455434 CDS YP_001933163.1 189025391 6333188 complement(180768..181454) 1 NC_010741.1 hypothetical protein 181454 6333188 TPASS_0158 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933163.1 180768 R 455434 CDS YP_001933164.1 189025392 6333192 complement(181458..182486) 1 NC_010741.1 hypothetical protein 182486 6333192 TPASS_0159 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933164.1 181458 R 455434 CDS YP_001933165.1 189025393 6333191 complement(182602..184455) 1 NC_010741.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 184455 proS 6333191 proS Treponema pallidum subsp. pallidum SS14 prolyl-tRNA synthetase YP_001933165.1 182602 R 455434 CDS YP_001933166.1 189025394 6332897 complement(184458..184550) 1 NC_010741.1 hypothetical protein 184550 6332897 TPASS_0161 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933166.1 184458 R 455434 CDS YP_001933167.1 189025395 6333193 complement(184567..185619) 1 NC_010741.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 185619 ruvB 6333193 ruvB Treponema pallidum subsp. pallidum SS14 Holliday junction DNA helicase RuvB YP_001933167.1 184567 R 455434 CDS YP_001933168.1 189025396 6333216 185794..186720 1 NC_010741.1 ABC transporter, periplasmic binding protein 186720 troA 6333216 troA Treponema pallidum subsp. pallidum SS14 ABC transporter, periplasmic binding protein YP_001933168.1 185794 D 455434 CDS YP_001933169.1 189025397 6333799 186868..187668 1 NC_010741.1 ABC transporter, ATP-binding protein 187668 troB 6333799 troB Treponema pallidum subsp. pallidum SS14 ABC transporter, ATP-binding protein YP_001933169.1 186868 D 455434 CDS YP_001933170.1 189025398 6333199 187640..188536 1 NC_010741.1 ABC transporter, permease protein 188536 troC 6333199 troC Treponema pallidum subsp. pallidum SS14 ABC transporter, permease protein YP_001933170.1 187640 D 455434 CDS YP_001933171.1 189025399 6332907 188540..189643 1 NC_010741.1 ABC transporter, permease protein 189643 troD 6332907 troD Treponema pallidum subsp. pallidum SS14 ABC transporter, permease protein YP_001933171.1 188540 D 455434 CDS YP_001933172.1 189025400 6333204 189653..190114 1 NC_010741.1 cation-activated repressor protein 190114 troR 6333204 troR Treponema pallidum subsp. pallidum SS14 cation-activated repressor protein YP_001933172.1 189653 D 455434 CDS YP_001933173.1 189025401 6333606 190194..190949 1 NC_010741.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 190949 gpmA 6333606 gpmA Treponema pallidum subsp. pallidum SS14 phosphoglyceromutase YP_001933173.1 190194 D 455434 CDS YP_001933174.1 189025402 6333795 191173..191271 1 NC_010741.1 hypothetical protein 191271 6333795 TPASS_0169 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933174.1 191173 D 455434 CDS YP_001933175.1 189025403 6333603 191268..192077 1 NC_010741.1 protein Pfs 192077 pfs 6333603 pfs Treponema pallidum subsp. pallidum SS14 protein Pfs YP_001933175.1 191268 D 455434 CDS YP_001933176.1 189025404 6333602 192177..192605 1 NC_010741.1 lipoprotein, 15 kDa 192605 tpp15 6333602 tpp15 Treponema pallidum subsp. pallidum SS14 lipoprotein, 15 kDa YP_001933176.1 192177 D 455434 CDS YP_001933177.1 189025405 6333604 complement(192753..193280) 1 NC_010741.1 hypothetical protein 193280 6333604 TPASS_0172 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933177.1 192753 R 455434 CDS YP_001933178.1 189025406 6332822 complement(193315..193998) 1 NC_010741.1 hypothetical protein 193998 6332822 TPASS_0173 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933178.1 193315 R 455434 CDS YP_001933179.1 189025407 6333039 complement(193967..194809) 1 NC_010741.1 hypothetical protein 194809 6333039 TPASS_0174 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933179.1 193967 R 455434 CDS YP_001933180.1 189025408 6333600 complement(194559..195191) 1 NC_010741.1 hypothetical protein 195191 6333600 TPASS_0175 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933180.1 194559 R 455434 CDS YP_001933181.1 189025409 6333038 complement(195222..195488) 1 NC_010741.1 hypothetical protein 195488 6333038 TPASS_0176 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933181.1 195222 R 455434 CDS YP_001933182.1 189025410 6332821 complement(195485..196795) 1 NC_010741.1 hypothetical protein 196795 6332821 TPASS_0177 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933182.1 195485 R 455434 CDS YP_001933183.1 189025411 6333037 complement(196889..197815) 1 NC_010741.1 hypothetical protein 197815 6333037 TPASS_0178 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933183.1 196889 R 455434 CDS YP_001933184.1 189025412 6332820 complement(197815..199698) 1 NC_010741.1 hypothetical protein 199698 6332820 TPASS_0179 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933184.1 197815 R 455434 CDS YP_001933185.1 189025413 6333601 complement(199640..199798) 1 NC_010741.1 hypothetical protein 199798 6333601 TPASS_0180 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933185.1 199640 R 455434 CDS YP_001933186.1 189025414 6333597 199791..200234 1 NC_010741.1 hypothetical protein 200234 6333597 TPASS_0181 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933186.1 199791 D 455434 CDS YP_001933187.1 189025415 6333036 200074..200853 1 NC_010741.1 hypothetical protein 200853 6333036 TPASS_0182 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933187.1 200074 D 455434 CDS YP_001933188.1 189025416 6333034 complement(200856..201701) 1 NC_010741.1 hypothetical protein 201701 6333034 TPASS_0183 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933188.1 200856 R 455434 CDS YP_001933189.1 189025417 6333595 complement(201706..202170) 1 NC_010741.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 202170 smpB 6333595 smpB Treponema pallidum subsp. pallidum SS14 SsrA-binding protein YP_001933189.1 201706 R 455434 CDS YP_001933190.1 189025418 6333592 202258..202965 1 NC_010741.1 signal peptidase I 202965 sip 6333592 sip Treponema pallidum subsp. pallidum SS14 signal peptidase I YP_001933190.1 202258 D 455434 CDS YP_001933191.1 189025419 6333591 203020..204201 1 NC_010741.1 oxygen-independent coproporphyrinogen III oxidase 204201 6333591 TPASS_0186 Treponema pallidum subsp. pallidum SS14 oxygen-independent coproporphyrinogen III oxidase YP_001933191.1 203020 D 455434 CDS YP_001933192.1 189025420 6333586 204265..205752 1 NC_010741.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 205752 tuf 6333586 tuf Treponema pallidum subsp. pallidum SS14 elongation factor Tu YP_001933192.1 204265 D 455434 CDS YP_001933193.1 189025421 6333593 205824..206132 1 NC_010741.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 206132 rpsJ 6333593 rpsJ Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S10 YP_001933193.1 205824 D 455434 CDS YP_001933194.1 189025422 6333033 206179..206805 1 NC_010741.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 206805 rplC 6333033 rplC Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L3 YP_001933194.1 206179 D 455434 CDS YP_001933195.1 189025423 6333590 206819..207469 1 NC_010741.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 207469 rplD 6333590 rplD Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L4 YP_001933195.1 206819 D 455434 CDS YP_001933196.1 189025424 6332819 207456..207740 1 NC_010741.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 207740 rplW 6332819 rplW Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L23 YP_001933196.1 207456 D 455434 CDS YP_001933197.1 189025425 6332817 207796..208617 1 NC_010741.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 208617 rplB 6332817 rplB Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L2 YP_001933197.1 207796 D 455434 CDS YP_001933198.1 189025426 6333585 208627..208914 1 NC_010741.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 208914 rpsS 6333585 rpsS Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S19 YP_001933198.1 208627 D 455434 CDS YP_001933199.1 189025427 6333032 208923..209297 1 NC_010741.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 209297 rplV 6333032 rplV Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L22 YP_001933199.1 208923 D 455434 CDS YP_001933200.1 189025428 6333030 209281..210024 1 NC_010741.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 210024 rpsC 6333030 rpsC Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S3 YP_001933200.1 209281 D 455434 CDS YP_001933201.1 189025429 6333029 210028..210447 1 NC_010741.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 210447 rplP 6333029 rplP Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L16 YP_001933201.1 210028 D 455434 CDS YP_001933202.1 189025430 6333584 210462..210680 1 NC_010741.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 210680 rpmC 6333584 rpmC Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L29 YP_001933202.1 210462 D 455434 CDS YP_001933203.1 189025431 6333583 210695..210949 1 NC_010741.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 210949 rpsQ 6333583 rpsQ Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S17 YP_001933203.1 210695 D 455434 CDS YP_001933204.1 189025432 6333581 210962..211330 1 NC_010741.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 211330 rplN 6333581 rplN Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L14 YP_001933204.1 210962 D 455434 CDS YP_001933205.1 189025433 6333028 211342..211653 1 NC_010741.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 211653 rplX 6333028 rplX Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L24 YP_001933205.1 211342 D 455434 CDS YP_001933206.1 189025434 6332816 211650..212207 1 NC_010741.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 212207 rplE 6332816 rplE Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L5 YP_001933206.1 211650 D 455434 CDS YP_001933207.1 189025435 6333582 212219..212404 1 NC_010741.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 212404 rpsN 6333582 rpsN Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S14 YP_001933207.1 212219 D 455434 CDS YP_001933208.1 189025436 6332815 212420..212818 1 NC_010741.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 212818 rpsH 6332815 rpsH Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S8 YP_001933208.1 212420 D 455434 CDS YP_001933209.1 189025437 6333571 212828..213367 1 NC_010741.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 213367 rplF 6333571 rplF Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L6 YP_001933209.1 212828 D 455434 CDS YP_001933210.1 189025438 6333026 213376..213738 1 NC_010741.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 213738 rplR 6333026 rplR Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L18 YP_001933210.1 213376 D 455434 CDS YP_001933211.1 189025439 6333580 213747..214265 1 NC_010741.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 214265 rpsE 6333580 rpsE Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S5 YP_001933211.1 213747 D 455434 CDS YP_001933212.1 189025440 6333025 214268..214453 1 NC_010741.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 214453 rpmD 6333025 rpmD Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L30 YP_001933212.1 214268 D 455434 CDS YP_001933213.1 189025441 6333576 214453..214914 1 NC_010741.1 late assembly protein; 50S ribosomal protein L15 214914 rplO 6333576 rplO Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L15 YP_001933213.1 214453 D 455434 CDS YP_001933214.1 189025442 6333569 214922..216274 1 NC_010741.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 216274 secY 6333569 secY Treponema pallidum subsp. pallidum SS14 preprotein translocase subunit SecY YP_001933214.1 214922 D 455434 CDS YP_001933215.1 189025443 6333578 216279..216392 1 NC_010741.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 216392 rpmJ 6333578 rpmJ Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L36 YP_001933215.1 216279 D 455434 CDS YP_001933216.1 189025444 6333024 216408..216773 1 NC_010741.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 216773 rpsM 6333024 rpsM Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S13 YP_001933216.1 216408 D 455434 CDS YP_001933217.1 189025445 6333573 216791..217171 1 NC_010741.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 217171 rpsK 6333573 rpsK Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S11 YP_001933217.1 216791 D 455434 CDS YP_001933218.1 189025446 6333572 217186..218241 1 NC_010741.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 218241 rpoA 6333572 rpoA Treponema pallidum subsp. pallidum SS14 DNA-directed RNA polymerase subunit alpha YP_001933218.1 217186 D 455434 CDS YP_001933219.1 189025447 6333570 218231..218725 1 NC_010741.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 218725 rplQ 6333570 rplQ Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L17 YP_001933219.1 218231 D 455434 CDS YP_001933220.1 189025448 6333566 218749..218946 1 NC_010741.1 hypothetical protein 218946 6333566 TPASS_0214 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933220.1 218749 D 455434 CDS YP_001933221.1 189025449 6332813 219152..219814 1 NC_010741.1 chaperone protein GrpE 219814 grpE 6332813 grpE Treponema pallidum subsp. pallidum SS14 chaperone protein GrpE YP_001933221.1 219152 D 455434 CDS YP_001933222.1 189025450 6333567 219930..221837 1 NC_010741.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 221837 dnaK 6333567 dnaK Treponema pallidum subsp. pallidum SS14 molecular chaperone DnaK YP_001933222.1 219930 D 455434 CDS YP_001933223.1 189025451 6332812 223384..224853 1 NC_010741.1 sigma factor SigB regulation protein 224853 6332812 TPASS_0218 Treponema pallidum subsp. pallidum SS14 sigma factor SigB regulation protein YP_001933223.1 223384 D 455434 CDS YP_001933224.1 189025452 6333565 224857..227004 1 NC_010741.1 sigma factor SigB regulation protein 227004 6333565 TPASS_0219 Treponema pallidum subsp. pallidum SS14 sigma factor SigB regulation protein YP_001933224.1 224857 D 455434 CDS YP_001933225.1 189025453 6333562 227033..227359 1 NC_010741.1 anti-sigma F factor antagonist 227359 spoIIAA1 6333562 spoIIAA1 Treponema pallidum subsp. pallidum SS14 anti-sigma F factor antagonist YP_001933225.1 227033 D 455434 CDS YP_001933226.1 189025454 6332811 227360..228142 1 NC_010741.1 D,D-carboxypeptidase 228142 6332811 TPASS_0221 Treponema pallidum subsp. pallidum SS14 D,D-carboxypeptidase YP_001933226.1 227360 D 455434 CDS YP_001933227.1 189025455 6333561 228152..228598 1 NC_010741.1 hypothetical protein 228598 6333561 TPASS_0222 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933227.1 228152 D 455434 CDS YP_001933228.1 189025456 6333564 228866..230173 1 NC_010741.1 hypothetical protein 230173 6333564 TPASS_0223 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933228.1 228866 D 455434 CDS YP_001933229.1 189025457 6333020 230210..230314 1 NC_010741.1 hypothetical protein 230314 6333020 TPASS_0224 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933229.1 230210 D 455434 CDS YP_001933230.1 189025458 6332810 230360..231100 1 NC_010741.1 leucine-rich repeat protein TpLRR 231100 6332810 TPASS_0225 Treponema pallidum subsp. pallidum SS14 leucine-rich repeat protein TpLRR YP_001933230.1 230360 D 455434 CDS YP_001933231.1 189025459 6333555 complement(236252..236938) 1 NC_010741.1 hypothetical protein 236938 6333555 TPASS_0226 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933231.1 236252 R 455434 CDS YP_001933232.1 189025460 6333018 complement(236991..237758) 1 NC_010741.1 cobalt ABC transporter, ATP-binding protein 237758 6333018 TPASS_0227 Treponema pallidum subsp. pallidum SS14 cobalt ABC transporter, ATP-binding protein YP_001933232.1 236991 R 455434 CDS YP_001933233.1 189025461 6332808 complement(237825..238640) 1 NC_010741.1 biotin synthase 238640 6332808 TPASS_0228 Treponema pallidum subsp. pallidum SS14 biotin synthase YP_001933233.1 237825 R 455434 CDS YP_001933234.1 189025462 6333016 238584..239417 1 NC_010741.1 DNA polymerase, bacteriophage-type 239417 6333016 TPASS_0229 Treponema pallidum subsp. pallidum SS14 DNA polymerase, bacteriophage-type YP_001933234.1 238584 D 455434 CDS YP_001933235.1 189025463 6333015 239422..241395 1 NC_010741.1 primosomal protein N 241395 priA 6333015 priA Treponema pallidum subsp. pallidum SS14 primosomal protein N YP_001933235.1 239422 D 455434 CDS YP_001933236.1 189025464 6333017 241496..242146 1 NC_010741.1 hypothetical protein 242146 6333017 TPASS_0231 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933236.1 241496 D 455434 CDS YP_001933237.1 189025465 6333552 242246..242362 1 NC_010741.1 hypothetical protein 242362 6333552 TPASS_0232 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933237.1 242246 D 455434 CDS YP_001933238.1 189025466 6332807 242393..242938 1 NC_010741.1 anti-sigma F factor antagonist 242938 6332807 TPASS_0233 Treponema pallidum subsp. pallidum SS14 anti-sigma F factor antagonist YP_001933238.1 242393 D 455434 CDS YP_001933239.1 189025467 6333551 243173..243343 1 NC_010741.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 243343 rpmG 6333551 rpmG Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L33 YP_001933239.1 243173 D 455434 CDS YP_001933240.1 189025468 6333548 243493..243672 1 NC_010741.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 243672 secE 6333548 secE Treponema pallidum subsp. pallidum SS14 preprotein translocase subunit SecE YP_001933240.1 243493 D 455434 CDS YP_001933241.1 189025469 6333014 243682..244239 1 NC_010741.1 transcription antitermination protein 244239 nusG 6333014 nusG Treponema pallidum subsp. pallidum SS14 transcription antitermination protein YP_001933241.1 243682 D 455434 CDS YP_001933242.1 189025470 6333013 244346..244786 1 NC_010741.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 244786 rplK 6333013 rplK Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L11 YP_001933242.1 244346 D 455434 CDS YP_001933243.1 189025471 6333544 244783..245463 1 NC_010741.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 245463 rplA 6333544 rplA Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L1 YP_001933243.1 244783 D 455434 CDS YP_001933244.1 189025472 6333541 245465..246007 1 NC_010741.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 246007 rplJ 6333541 rplJ Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L10 YP_001933244.1 245465 D 455434 CDS YP_001933245.1 189025473 6333012 246116..246505 1 NC_010741.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 246505 rplL 6333012 rplL Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L7/L12 YP_001933245.1 246116 D 455434 CDS YP_001933246.1 189025474 6333545 246768..250304 1 NC_010741.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 250304 rpoB 6333545 rpoB Treponema pallidum subsp. pallidum SS14 DNA-directed RNA polymerase subunit beta YP_001933246.1 246768 D 455434 CDS YP_001933247.1 189025475 6333543 250317..254567 1 NC_010741.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 254567 rpoC 6333543 rpoC Treponema pallidum subsp. pallidum SS14 DNA-directed RNA polymerase subunit beta' YP_001933247.1 250317 D 455434 CDS YP_001933248.1 189025476 6332806 254670..255044 1 NC_010741.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 255044 rpsL 6332806 rpsL Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S12 YP_001933248.1 254670 D 455434 CDS YP_001933249.1 189025477 6333011 255066..255536 1 NC_010741.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 255536 rpsG 6333011 rpsG Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S7 YP_001933249.1 255066 D 455434 CDS YP_001933250.1 189025478 6333539 255560..259015 1 NC_010741.1 hypothetical protein 259015 6333539 TPASS_0245 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933250.1 255560 D 455434 CDS YP_001933251.1 189025479 6333538 259161..260954 1 NC_010741.1 hypothetical protein 260954 6333538 TPASS_0246 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933251.1 259161 D 455434 CDS YP_001933252.1 189025480 6332803 261005..262078 1 NC_010741.1 N-acetylmuramoyl-L-alanine amidase 262078 amiA 6332803 amiA Treponema pallidum subsp. pallidum SS14 N-acetylmuramoyl-L-alanine amidase YP_001933252.1 261005 D 455434 CDS YP_001933253.1 189025481 6333533 262145..262549 1 NC_010741.1 hypothetical protein 262549 6333533 TPASS_0248 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933253.1 262145 D 455434 CDS YP_001933254.1 189025482 6333537 262628..263680 1 NC_010741.1 flagellar filament outer layer protein 263680 flaA1 6333537 flaA1 Treponema pallidum subsp. pallidum SS14 flagellar filament outer layer protein YP_001933254.1 262628 D 455434 CDS YP_001933255.1 189025483 6333532 263731..263958 1 NC_010741.1 hypothetical protein 263958 6333532 TPASS_0250a Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933255.1 263731 D 455434 CDS YP_001933256.1 189025484 6333536 263793..264080 1 NC_010741.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 264080 rpsT 6333536 rpsT Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S20 YP_001933256.1 263793 D 455434 CDS YP_001933257.1 189025485 6333535 264112..264429 1 NC_010741.1 DNA-binding protein II 264429 6333535 TPASS_0251 Treponema pallidum subsp. pallidum SS14 DNA-binding protein II YP_001933257.1 264112 D 455434 CDS YP_001933258.1 189025486 6333534 264419..266059 1 NC_010741.1 apolipoprotein N-acyltransferase 266059 6333534 TPASS_0252 Treponema pallidum subsp. pallidum SS14 apolipoprotein N-acyltransferase YP_001933258.1 264419 D 455434 CDS YP_001933259.1 189025487 6333526 266050..266463 1 NC_010741.1 hypothetical protein 266463 6333526 TPASS_0253 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933259.1 266050 D 455434 CDS YP_001933260.1 189025488 6333531 266700..268259 1 NC_010741.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 268259 rho 6333531 rho Treponema pallidum subsp. pallidum SS14 transcription termination factor Rho YP_001933260.1 266700 D 455434 CDS YP_001933261.1 189025489 6333529 268378..268581 1 NC_010741.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 268581 rpmE 6333529 rpmE Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L31 YP_001933261.1 268378 D 455434 CDS YP_001933262.1 189025490 6333530 268626..269276 1 NC_010741.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 269276 pgsA 6333530 pgsA Treponema pallidum subsp. pallidum SS14 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_001933262.1 268626 D 455434 CDS YP_001933263.1 189025491 6332802 269373..270443 1 NC_010741.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 270443 glpQ 6332802 glpQ Treponema pallidum subsp. pallidum SS14 glycerophosphodiester phosphodiesterase YP_001933263.1 269373 D 455434 CDS YP_001933264.1 189025492 6333004 complement(270509..271219) 1 NC_010741.1 hypothetical protein 271219 6333004 TPASS_0258 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933264.1 270509 R 455434 CDS YP_001933265.1 189025493 6333527 271298..271909 1 NC_010741.1 hypothetical protein 271909 6333527 TPASS_0259 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933265.1 271298 D 455434 CDS YP_001933266.1 189025494 6333524 complement(272040..273386) 1 NC_010741.1 hypothetical protein 273386 6333524 TPASS_0260 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933266.1 272040 R 455434 CDS YP_001933267.1 189025495 6333002 273501..274544 1 NC_010741.1 catabolite gene activator 274544 6333002 TPASS_0261 Treponema pallidum subsp. pallidum SS14 catabolite gene activator YP_001933267.1 273501 D 455434 CDS YP_001933268.1 189025496 6333003 274522..275196 1 NC_010741.1 catabolite gene activator 275196 crp 6333003 crp Treponema pallidum subsp. pallidum SS14 catabolite gene activator YP_001933268.1 274522 D 455434 CDS YP_001933269.1 189025497 6332801 275211..276995 1 NC_010741.1 hypothetical protein 276995 6332801 TPASS_0263 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933269.1 275211 D 455434 CDS YP_001933270.1 189025498 6333525 277000..277656 1 NC_010741.1 deoxyribose-phosphate aldolase 277656 deoC 6333525 deoC Treponema pallidum subsp. pallidum SS14 deoxyribose-phosphate aldolase YP_001933270.1 277000 D 455434 CDS YP_001933271.1 189025499 6333001 complement(278088..279455) 1 NC_010741.1 amino acid ABC transporter, permease protein 279455 braC 6333001 braC Treponema pallidum subsp. pallidum SS14 amino acid ABC transporter, permease protein YP_001933271.1 278088 R 455434 CDS YP_001933272.1 189025500 6333521 279506..279631 1 NC_010741.1 hypothetical protein 279631 6333521 TPASS_0266 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933272.1 279506 D 455434 CDS YP_001933273.1 189025501 6333000 284740..285105 1 NC_010741.1 hypothetical protein 285105 6333000 TPASS_0267 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933273.1 284740 D 455434 CDS YP_001933274.1 189025502 6333517 285102..285755 1 NC_010741.1 hypothetical protein 285755 6333517 TPASS_0268 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933274.1 285102 D 455434 CDS YP_001933275.1 189025503 6333513 285765..287213 1 NC_010741.1 hypothetical protein 287213 6333513 TPASS_0269 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933275.1 285765 D 455434 CDS YP_001933276.1 189025504 6333518 287287..288723 1 NC_010741.1 polynucleotide adenylyltransferase 288723 pcnA 6333518 pcnA Treponema pallidum subsp. pallidum SS14 polynucleotide adenylyltransferase YP_001933276.1 287287 D 455434 CDS YP_001933277.1 189025505 6332798 complement(288720..289694) 1 NC_010741.1 chromosome partitioning protein 289694 parB 6332798 parB Treponema pallidum subsp. pallidum SS14 chromosome partitioning protein YP_001933277.1 288720 R 455434 CDS YP_001933278.1 189025506 6333515 complement(289681..290442) 1 NC_010741.1 chromosome partitioning protein 290442 parA 6333515 parA Treponema pallidum subsp. pallidum SS14 chromosome partitioning protein YP_001933278.1 289681 R 455434 CDS YP_001933279.1 189025507 6333514 290575..291366 1 NC_010741.1 hypothetical protein 291366 6333514 TPASS_0273 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933279.1 290575 D 455434 CDS YP_001933280.1 189025508 6332998 complement(291404..291904) 1 NC_010741.1 deoxycytidylate deaminase 291904 6332998 TPASS_0274 Treponema pallidum subsp. pallidum SS14 deoxycytidylate deaminase YP_001933280.1 291404 R 455434 CDS YP_001933281.1 189025509 6333516 complement(291993..292742) 1 NC_010741.1 UDP-N-acetyl-D-mannosamine transferase 292742 6333516 TPASS_0275 Treponema pallidum subsp. pallidum SS14 UDP-N-acetyl-D-mannosamine transferase YP_001933281.1 291993 R 455434 CDS YP_001933282.1 189025510 6333512 complement(292721..293605) 1 NC_010741.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 293605 6333512 TPASS_0276 Treponema pallidum subsp. pallidum SS14 16S ribosomal RNA methyltransferase RsmE YP_001933282.1 292721 R 455434 CDS YP_001933283.1 189025511 6333508 complement(293778..295124) 1 NC_010741.1 carboxyl-terminal protease 295124 ctp 6333508 ctp Treponema pallidum subsp. pallidum SS14 carboxyl-terminal protease YP_001933283.1 293778 R 455434 CDS YP_001933284.1 189025512 6333511 295252..295380 1 NC_010741.1 hypothetical protein 295380 6333511 TPASS_0278 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933284.1 295252 D 455434 CDS YP_001933285.1 189025513 6332996 295426..298017 1 NC_010741.1 proteins from Treponema appear to be a fusion of cytidylate kinase and multiple (up to 6) S1 domains; bifunctional cytidylate kinase/ribosomal protein S1 298017 rpsA 6332996 rpsA Treponema pallidum subsp. pallidum SS14 bifunctional cytidylate kinase/ribosomal protein S1 YP_001933285.1 295426 D 455434 CDS YP_001933286.1 189025514 6333507 298014..298142 1 NC_010741.1 hypothetical protein 298142 6333507 TPASS_0280 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933286.1 298014 D 455434 CDS YP_001933287.1 189025515 6333509 298159..298287 1 NC_010741.1 hypothetical protein 298287 6333509 TPASS_0281 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933287.1 298159 D 455434 CDS YP_001933288.1 189025516 6332995 298280..298999 1 NC_010741.1 hypothetical protein 298999 6332995 TPASS_0282 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933288.1 298280 D 455434 CDS YP_001933289.1 189025517 6333506 299177..299656 1 NC_010741.1 lipopolysaccharide core biosynthesis protein 299656 kdtB 6333506 kdtB Treponema pallidum subsp. pallidum SS14 lipopolysaccharide core biosynthesis protein YP_001933289.1 299177 D 455434 CDS YP_001933290.1 189025518 6332797 299761..300420 1 NC_010741.1 hypothetical protein 300420 6332797 TPASS_0284 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933290.1 299761 D 455434 CDS YP_001933291.1 189025519 6333505 300360..301439 1 NC_010741.1 hypothetical protein 301439 6333505 TPASS_0285 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933291.1 300360 D 455434 CDS YP_001933292.1 189025520 6332993 301411..301776 1 NC_010741.1 hypothetical protein 301776 6332993 TPASS_0286 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933292.1 301411 D 455434 CDS YP_001933293.1 189025521 6333504 301743..302366 1 NC_010741.1 hypothetical protein 302366 6333504 TPASS_0287 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933293.1 301743 D 455434 CDS YP_001933294.1 189025522 6333502 302366..303313 1 NC_010741.1 spore coat polysaccharide biosynthesis protein F 303313 spsF 6333502 spsF Treponema pallidum subsp. pallidum SS14 spore coat polysaccharide biosynthesis protein F YP_001933294.1 302366 D 455434 CDS YP_001933295.1 189025523 6332992 303336..304940 1 NC_010741.1 hypothetical protein 304940 6332992 TPASS_0289 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933295.1 303336 D 455434 CDS YP_001933296.1 189025524 6333501 304995..305828 1 NC_010741.1 hypothetical protein 305828 6333501 TPASS_0290 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933296.1 304995 D 455434 CDS YP_001933297.1 189025525 6333499 305865..306746 1 NC_010741.1 hypothetical protein 306746 6333499 TPASS_0291 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933297.1 305865 D 455434 CDS YP_001933298.1 189025526 6333503 306737..307990 1 NC_010741.1 outer membrane protein TpN50 307990 tpn50 6333503 tpn50 Treponema pallidum subsp. pallidum SS14 outer membrane protein TpN50 YP_001933298.1 306737 D 455434 CDS YP_001933299.1 189025527 6332990 308002..308178 1 NC_010741.1 hypothetical protein 308178 6332990 TPASS_0293 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933299.1 308002 D 455434 CDS YP_001933300.1 189025528 6332991 308156..309421 1 NC_010741.1 Catalyzes the formation of PRPP from ATP and ribose 5-phosphate; phosphoribosylpyrophosphate synthetase 309421 prs 6332991 prs Treponema pallidum subsp. pallidum SS14 phosphoribosylpyrophosphate synthetase YP_001933300.1 308156 D 455434 CDS YP_001933301.1 189025529 6332989 309440..310684 1 NC_010741.1 carhohydrate kinase 310684 xylB 6332989 xylB Treponema pallidum subsp. pallidum SS14 carhohydrate kinase YP_001933301.1 309440 D 455434 CDS YP_001933302.1 189025530 6333498 310770..311405 1 NC_010741.1 hypothetical protein 311405 6333498 TPASS_0296 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933302.1 310770 D 455434 CDS YP_001933303.1 189025531 6333495 311369..312181 1 NC_010741.1 hypothetical protein 312181 6333495 TPASS_0297 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933303.1 311369 D 455434 CDS YP_001933304.1 189025532 6333497 312314..313345 1 NC_010741.1 exported protein TpN38b 313345 tpn38b 6333497 tpn38b Treponema pallidum subsp. pallidum SS14 exported protein TpN38b YP_001933304.1 312314 D 455434 CDS YP_001933305.1 189025533 6332988 313342..313566 1 NC_010741.1 hypothetical protein 313566 6332988 TPASS_0299 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933305.1 313342 D 455434 CDS YP_001933306.1 189025534 6332986 313551..315101 1 NC_010741.1 ribose/galactose ABC transporter, ATP-binding protein 315101 rbsA1 6332986 rbsA1 Treponema pallidum subsp. pallidum SS14 ribose/galactose ABC transporter, ATP-binding protein YP_001933306.1 313551 D 455434 CDS YP_001933307.1 189025535 6332987 315098..316231 1 NC_010741.1 hypothetical protein 316231 6332987 TPASS_0301 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933307.1 315098 D 455434 CDS YP_001933308.1 189025536 6333496 316222..317163 1 NC_010741.1 hypothetical protein 317163 6333496 TPASS_0302 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933308.1 316222 D 455434 CDS YP_001933309.1 189025537 6333489 complement(317150..319096) 1 NC_010741.1 DNA mismatch repair protein MutL 319096 mutL 6333489 mutL Treponema pallidum subsp. pallidum SS14 DNA mismatch repair protein MutL YP_001933309.1 317150 R 455434 CDS YP_001933310.1 189025538 6333493 complement(319109..322225) 1 NC_010741.1 hypothetical protein 322225 6333493 TPASS_0304 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933310.1 319109 R 455434 CDS YP_001933311.1 189025539 6333491 322152..323885 1 NC_010741.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 323885 pyrG 6333491 pyrG Treponema pallidum subsp. pallidum SS14 CTP synthetase YP_001933311.1 322152 D 455434 CDS YP_001933312.1 189025540 6333490 324050..324664 1 NC_010741.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 324664 rpsD 6333490 rpsD Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S4 YP_001933312.1 324050 D 455434 CDS YP_001933313.1 189025541 6332982 324751..325779 1 NC_010741.1 hypothetical protein 325779 6332982 TPASS_0307 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933313.1 324751 D 455434 CDS YP_001933314.1 189025542 6332985 325754..326719 1 NC_010741.1 amino acid ABC transporter, periplasmic binding protein 326719 hisJ 6332985 hisJ Treponema pallidum subsp. pallidum SS14 amino acid ABC transporter, periplasmic binding protein YP_001933314.1 325754 D 455434 CDS YP_001933315.1 189025543 6333486 326785..327603 1 NC_010741.1 amino acid ABC transporter, periplasmic binding protein 327603 6333486 TPASS_0309 Treponema pallidum subsp. pallidum SS14 amino acid ABC transporter, periplasmic binding protein YP_001933315.1 326785 D 455434 CDS YP_001933316.1 189025544 6332983 327572..327955 1 NC_010741.1 hypothetical protein 327955 6332983 TPASS_0310 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933316.1 327572 D 455434 CDS YP_001933317.1 189025545 6332984 complement(327934..328077) 1 NC_010741.1 hypothetical protein 328077 6332984 TPASS_0311 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933317.1 327934 R 455434 CDS YP_001933318.1 189025546 6333485 328061..329074 1 NC_010741.1 hypothetical protein 329074 6333485 TPASS_0312 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933318.1 328061 D 455434 CDS YP_001933319.1 189025547 6333483 329165..331453 1 NC_010741.1 protein TprE 331453 tprE 6333483 tprE Treponema pallidum subsp. pallidum SS14 protein TprE YP_001933319.1 329165 D 455434 CDS YP_001933320.1 189025548 6333484 complement(331510..331656) 1 NC_010741.1 hypothetical protein 331656 6333484 TPASS_0314 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933320.1 331510 R 455434 CDS YP_001933321.1 189025549 6333480 complement(331679..332326) 1 NC_010741.1 hypothetical protein 332326 6333480 TPASS_0315 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933321.1 331679 R 455434 CDS YP_001933322.1 189025550 6332981 complement(333573..335843) 1 NC_010741.1 protein TprG 335843 tprG 6332981 tprG Treponema pallidum subsp. pallidum SS14 protein TprG YP_001933322.1 333573 R 455434 CDS YP_001933323.1 189025551 6333478 complement(335795..335974) 1 NC_010741.1 hypothetical protein 335974 6333478 TPASS_0318 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933323.1 335795 R 455434 CDS YP_001933324.1 189025552 6332978 336003..337064 1 NC_010741.1 membrane lipoprotein TmpC 337064 tmpC 6332978 tmpC Treponema pallidum subsp. pallidum SS14 membrane lipoprotein TmpC YP_001933324.1 336003 D 455434 CDS YP_001933325.1 189025553 6333479 337074..337229 1 NC_010741.1 hypothetical protein 337229 6333479 TPASS_0320 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933325.1 337074 D 455434 CDS YP_001933326.1 189025554 6332977 337305..338906 1 NC_010741.1 ribose/galactose ABC transporter, ATP-binding protein 338906 rbsA2 6332977 rbsA2 Treponema pallidum subsp. pallidum SS14 ribose/galactose ABC transporter, ATP-binding protein YP_001933326.1 337305 D 455434 CDS YP_001933327.1 189025555 6332979 338816..340018 1 NC_010741.1 ribose/galactose ABC transporter, permease protein 340018 rbsC1 6332979 rbsC1 Treponema pallidum subsp. pallidum SS14 ribose/galactose ABC transporter, permease protein YP_001933327.1 338816 D 455434 CDS YP_001933328.1 189025556 6333474 340015..340965 1 NC_010741.1 ribose/galactose ABC transporter, permease protein 340965 rbsC2 6333474 rbsC2 Treponema pallidum subsp. pallidum SS14 ribose/galactose ABC transporter, permease protein YP_001933328.1 340015 D 455434 CDS YP_001933329.1 189025557 6332976 341069..342526 1 NC_010741.1 hypothetical protein 342526 6332976 TPASS_0324 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933329.1 341069 D 455434 CDS YP_001933330.1 189025558 6333473 342508..345474 1 NC_010741.1 hypothetical protein 345474 6333473 TPASS_0325 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933330.1 342508 D 455434 CDS YP_001933331.1 189025559 6333472 345456..348017 1 NC_010741.1 outer membrane protein 348017 6333472 TPASS_0326 Treponema pallidum subsp. pallidum SS14 outer membrane protein YP_001933331.1 345456 D 455434 CDS YP_001933332.1 189025560 6332974 348074..348592 1 NC_010741.1 cationic outer membrane protein 348592 ompH 6332974 ompH Treponema pallidum subsp. pallidum SS14 cationic outer membrane protein YP_001933332.1 348074 D 455434 CDS YP_001933333.1 189025561 6332975 348648..351350 1 NC_010741.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 351350 mutS 6332975 mutS Treponema pallidum subsp. pallidum SS14 DNA mismatch repair protein MutS YP_001933333.1 348648 D 455434 CDS YP_001933334.1 189025562 6332973 351468..353192 1 NC_010741.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 353192 glyA 6332973 glyA Treponema pallidum subsp. pallidum SS14 serine hydroxymethyltransferase YP_001933334.1 351468 D 455434 CDS YP_001933335.1 189025563 6333467 complement(353166..354962) 1 NC_010741.1 cell division protein 354962 6333467 TPASS_0330 Treponema pallidum subsp. pallidum SS14 cell division protein YP_001933335.1 353166 R 455434 CDS YP_001933336.1 189025564 6333465 complement(355192..356658) 1 NC_010741.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 356658 gnd 6333465 gnd Treponema pallidum subsp. pallidum SS14 6-phosphogluconate dehydrogenase YP_001933336.1 355192 R 455434 CDS YP_001933337.1 189025565 6333464 356674..356799 1 NC_010741.1 hypothetical protein 356799 6333464 TPASS_0332 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933337.1 356674 D 455434 CDS YP_001933338.1 189025566 6333459 356837..357529 1 NC_010741.1 hypothetical protein 357529 6333459 TPASS_0333 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933338.1 356837 D 455434 CDS YP_001933339.1 189025567 6332972 357554..358771 1 NC_010741.1 hypothetical protein 358771 6332972 TPASS_0334 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933339.1 357554 D 455434 CDS YP_001933340.1 189025568 6333460 complement(358768..359310) 1 NC_010741.1 hypothetical protein 359310 6333460 TPASS_0335 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933340.1 358768 R 455434 CDS YP_001933341.1 189025569 6333463 359153..360853 1 NC_010741.1 protein ComE 360853 6333463 TPASS_0336 Treponema pallidum subsp. pallidum SS14 protein ComE YP_001933341.1 359153 D 455434 CDS YP_001933342.1 189025570 6332952 360834..361691 1 NC_010741.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 361691 ksgA 6332952 ksgA Treponema pallidum subsp. pallidum SS14 dimethyladenosine transferase YP_001933342.1 360834 D 455434 CDS YP_001933343.1 189025571 6333456 361709..362197 1 NC_010741.1 hypothetical protein 362197 6333456 TPASS_0338 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933343.1 361709 D 455434 CDS YP_001933344.1 189025572 6333457 362209..363204 1 NC_010741.1 hypothetical protein 363204 6333457 TPASS_0339 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933344.1 362209 D 455434 CDS YP_001933345.1 189025573 6333454 complement(363190..364662) 1 NC_010741.1 folylpolyglutamate synthetase 364662 folC 6333454 folC Treponema pallidum subsp. pallidum SS14 folylpolyglutamate synthetase YP_001933345.1 363190 R 455434 CDS YP_001933346.1 189025574 6333455 364681..366126 1 NC_010741.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 366126 murC 6333455 murC Treponema pallidum subsp. pallidum SS14 UDP-N-acetylmuramate--L-alanine ligase YP_001933346.1 364681 D 455434 CDS YP_001933347.1 189025575 6333453 366247..366807 1 NC_010741.1 catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 366807 cmk 6333453 cmk Treponema pallidum subsp. pallidum SS14 cytidylate kinase YP_001933347.1 366247 D 455434 CDS YP_001933348.1 189025576 6333450 366801..367634 1 NC_010741.1 A/G-specific adenine glycosylase 367634 6333450 TPASS_0343 Treponema pallidum subsp. pallidum SS14 A/G-specific adenine glycosylase YP_001933348.1 366801 D 455434 CDS YP_001933349.1 189025577 6332964 complement(367639..371061) 1 NC_010741.1 transcription-repair coupling factor 371061 trcF 6332964 trcF Treponema pallidum subsp. pallidum SS14 transcription-repair coupling factor YP_001933349.1 367639 R 455434 CDS YP_001933350.1 189025578 6333452 371214..372305 1 NC_010741.1 phospho-N-acetylmuramoyl-pentapeptide- transferase 372305 mraY 6333452 mraY Treponema pallidum subsp. pallidum SS14 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_001933350.1 371214 D 455434 CDS YP_001933351.1 189025579 6333451 372462..373163 1 NC_010741.1 hypothetical protein 373163 6333451 TPASS_0346 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933351.1 372462 D 455434 CDS YP_001933352.1 189025580 6333445 373132..373962 1 NC_010741.1 hypothetical protein 373962 6333445 TPASS_0347 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933352.1 373132 D 455434 CDS YP_001933353.1 189025581 6332968 complement(373696..375105) 1 NC_010741.1 hypothetical protein 375105 6332968 TPASS_0348 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933353.1 373696 R 455434 CDS YP_001933354.1 189025582 6332967 complement(375075..375605) 1 NC_010741.1 peptidyl-prolyl cis-trans isomerase, FKBP-type 375605 slyD 6332967 slyD Treponema pallidum subsp. pallidum SS14 peptidyl-prolyl cis-trans isomerase, FKBP-type YP_001933354.1 375075 R 455434 CDS YP_001933355.1 189025583 6333448 375819..377105 1 NC_010741.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 377105 proA 6333448 proA Treponema pallidum subsp. pallidum SS14 gamma-glutamyl phosphate reductase YP_001933355.1 375819 D 455434 CDS YP_001933356.1 189025584 6332966 377102..377992 1 NC_010741.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 377992 proB 6332966 proB Treponema pallidum subsp. pallidum SS14 gamma-glutamyl kinase YP_001933356.1 377102 D 455434 CDS YP_001933357.1 189025585 6332965 378124..378381 1 NC_010741.1 hypothetical protein 378381 6332965 TPASS_0352 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933357.1 378124 D 455434 CDS YP_001933358.1 189025586 6333444 complement(378378..378887) 1 NC_010741.1 ribonuclease H 378887 rnhA 6333444 rnhA Treponema pallidum subsp. pallidum SS14 ribonuclease H YP_001933358.1 378378 R 455434 CDS YP_001933359.1 189025587 6333447 379150..379776 1 NC_010741.1 thymidylate kinase 379776 tmk 6333447 tmk Treponema pallidum subsp. pallidum SS14 thymidylate kinase YP_001933359.1 379150 D 455434 CDS YP_001933360.1 189025588 6333442 complement(379743..380126) 1 NC_010741.1 hypothetical protein 380126 6333442 TPASS_0355 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933360.1 379743 R 455434 CDS YP_001933361.1 189025589 6333441 380331..380648 1 NC_010741.1 RNA-binding protein 380648 6333441 TPASS_0356 Treponema pallidum subsp. pallidum SS14 RNA-binding protein YP_001933361.1 380331 D 455434 CDS YP_001933362.1 189025590 6332963 380750..381490 1 NC_010741.1 biotin--acetyl-CoA-carboxylase ligase 381490 birA 6332963 birA Treponema pallidum subsp. pallidum SS14 biotin--acetyl-CoA-carboxylase ligase YP_001933362.1 380750 D 455434 CDS YP_001933363.1 189025591 6333387 complement(381495..383075) 1 NC_010741.1 hypothetical protein 383075 6333387 TPASS_0358 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933363.1 381495 R 455434 CDS YP_001933364.1 189025592 6332938 complement(383087..383722) 1 NC_010741.1 hypothetical protein 383722 6332938 TPASS_0359 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933364.1 383087 R 455434 CDS YP_001933365.1 189025593 6333443 383933..384109 1 NC_010741.1 hypothetical protein 384109 6333443 TPASS_0360 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933365.1 383933 D 455434 CDS YP_001933366.1 189025594 6333439 complement(384106..384954) 1 NC_010741.1 lysophosphatidic acid acyltransferase 384954 6333439 TPASS_0361 Treponema pallidum subsp. pallidum SS14 lysophosphatidic acid acyltransferase YP_001933366.1 384106 R 455434 CDS YP_001933367.1 189025595 6333386 385030..385266 1 NC_010741.1 required for 70S ribosome assembly; 50S ribosomal protein L28 385266 rpmB 6333386 rpmB Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L28 YP_001933367.1 385030 D 455434 CDS YP_001933368.1 189025596 6333440 385758..388196 1 NC_010741.1 chemotaxis histidine kinase 388196 cheA 6333440 cheA Treponema pallidum subsp. pallidum SS14 chemotaxis histidine kinase YP_001933368.1 385758 D 455434 CDS YP_001933369.1 189025597 6333436 388190..389557 1 NC_010741.1 purine-binding chemotaxis protein 389557 cheW1 6333436 cheW1 Treponema pallidum subsp. pallidum SS14 purine-binding chemotaxis protein YP_001933369.1 388190 D 455434 CDS YP_001933370.1 189025598 6333427 389579..390043 1 NC_010741.1 chemotaxis protein 390043 cheX 6333427 cheX Treponema pallidum subsp. pallidum SS14 chemotaxis protein YP_001933370.1 389579 D 455434 CDS YP_001933371.1 189025599 6333437 390056..390490 1 NC_010741.1 chemotaxis response regulator 390490 cheY 6333437 cheY Treponema pallidum subsp. pallidum SS14 chemotaxis response regulator YP_001933371.1 390056 D 455434 CDS YP_001933372.1 189025600 6333433 390794..393619 1 NC_010741.1 chromosome segregation protein 393619 6333433 TPASS_0367 Treponema pallidum subsp. pallidum SS14 chromosome segregation protein YP_001933372.1 390794 D 455434 CDS YP_001933373.1 189025601 6333432 393619..393954 1 NC_010741.1 hypothetical protein 393954 6333432 TPASS_0368 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933373.1 393619 D 455434 CDS YP_001933374.1 189025602 6332954 393951..395501 1 NC_010741.1 hypothetical protein 395501 6332954 TPASS_0369 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933374.1 393951 D 455434 CDS YP_001933375.1 189025603 6332958 complement(395569..395985) 1 NC_010741.1 hypothetical protein 395985 6332958 TPASS_0370 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933375.1 395569 R 455434 CDS YP_001933376.1 189025604 6333425 395959..396834 1 NC_010741.1 hypothetical protein 396834 6333425 TPASS_0371 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933376.1 395959 D 455434 CDS YP_001933377.1 189025605 6333415 396956..397546 1 NC_010741.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25/general stress protein Ctc 397546 ctc 6333415 ctc Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L25/general stress protein Ctc YP_001933377.1 396956 D 455434 CDS YP_001933378.1 189025606 6332951 397606..399039 1 NC_010741.1 hypothetical protein 399039 6332951 TPASS_0373 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933378.1 397606 D 455434 CDS YP_001933379.1 189025607 6333405 398975..401350 1 NC_010741.1 hypothetical protein 401350 6333405 TPASS_0374 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933379.1 398975 D 455434 CDS YP_001933380.1 189025608 6332945 401508..401717 1 NC_010741.1 hypothetical protein 401717 6332945 TPASS_0375 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933380.1 401508 D 455434 CDS YP_001933381.1 189025609 6332948 complement(402033..402938) 1 NC_010741.1 hypothetical protein 402938 6332948 TPASS_0376 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933381.1 402033 R 455434 CDS YP_001933382.1 189025610 6333403 403007..403132 1 NC_010741.1 hypothetical protein 403132 6333403 TPASS_0377 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933382.1 403007 D 455434 CDS YP_001933383.1 189025611 6333399 403129..403509 1 NC_010741.1 flagellar protein 403509 6333399 TPASS_0378 Treponema pallidum subsp. pallidum SS14 flagellar protein YP_001933383.1 403129 D 455434 CDS YP_001933384.1 189025612 6333400 complement(403584..406334) 1 NC_010741.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 406334 secA 6333400 secA Treponema pallidum subsp. pallidum SS14 preprotein translocase subunit SecA YP_001933384.1 403584 R 455434 CDS YP_001933385.1 189025613 6333398 complement(406441..408261) 1 NC_010741.1 DNA repair helicase 408261 6333398 TPASS_0380 Treponema pallidum subsp. pallidum SS14 DNA repair helicase YP_001933385.1 406441 R 455434 CDS YP_001933386.1 189025614 6333396 complement(408399..409115) 1 NC_010741.1 hypothetical protein 409115 6333396 TPASS_0381 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933386.1 408399 R 455434 CDS YP_001933387.1 189025615 6333393 409199..409321 1 NC_010741.1 hypothetical protein 409321 6333393 TPASS_0382 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933387.1 409199 D 455434 CDS YP_001933388.1 189025616 6332942 409349..409798 1 NC_010741.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 409798 6332942 TPASS_0383 Treponema pallidum subsp. pallidum SS14 cell division protein MraZ YP_001933388.1 409349 D 455434 CDS YP_001933389.1 189025617 6333390 409795..410934 1 NC_010741.1 hypothetical protein 410934 6333390 TPASS_0384 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933389.1 409795 D 455434 CDS YP_001933390.1 189025618 6332927 410947..411321 1 NC_010741.1 hypothetical protein 411321 6332927 TPASS_0385 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933390.1 410947 D 455434 CDS YP_001933391.1 189025619 6333392 411305..412684 1 NC_010741.1 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine 412684 murF 6333392 murF Treponema pallidum subsp. pallidum SS14 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine YP_001933391.1 411305 D 455434 CDS YP_001933392.1 189025620 6333389 412681..413835 1 NC_010741.1 cell division protein 413835 ftsW 6333389 ftsW Treponema pallidum subsp. pallidum SS14 cell division protein YP_001933392.1 412681 D 455434 CDS YP_001933393.1 189025621 6332931 413813..414628 1 NC_010741.1 cell division protein 414628 ftsQ 6332931 ftsQ Treponema pallidum subsp. pallidum SS14 cell division protein YP_001933393.1 413813 D 455434 CDS YP_001933394.1 189025622 6332930 414641..415885 1 NC_010741.1 cell division protein 415885 ftsA 6332930 ftsA Treponema pallidum subsp. pallidum SS14 cell division protein YP_001933394.1 414641 D 455434 CDS YP_001933395.1 189025623 6332932 415931..417187 1 NC_010741.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 417187 ftsZ 6332932 ftsZ Treponema pallidum subsp. pallidum SS14 cell division protein FtsZ YP_001933395.1 415931 D 455434 CDS YP_001933396.1 189025624 6333376 417184..418104 1 NC_010741.1 integrase/recombinase 418104 codV 6333376 codV Treponema pallidum subsp. pallidum SS14 integrase/recombinase YP_001933396.1 417184 D 455434 CDS YP_001933397.1 189025625 6333379 417887..418846 1 NC_010741.1 hypothetical protein 418846 6333379 TPASS_0392 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933397.1 417887 D 455434 CDS YP_001933398.1 189025626 6333377 418843..419751 1 NC_010741.1 protein Smf 419751 smf 6333377 smf Treponema pallidum subsp. pallidum SS14 protein Smf YP_001933398.1 418843 D 455434 CDS YP_001933399.1 189025627 6333446 419784..421979 1 NC_010741.1 DNA topoisomerase I 421979 topA 6333446 topA Treponema pallidum subsp. pallidum SS14 DNA topoisomerase I YP_001933399.1 419784 D 455434 CDS YP_001933400.1 189025628 6333461 421972..422865 1 NC_010741.1 integrase/recombinase 422865 xprB 6333461 xprB Treponema pallidum subsp. pallidum SS14 integrase/recombinase YP_001933400.1 421972 D 455434 CDS YP_001933401.1 189025629 6333381 423013..423423 1 NC_010741.1 flagellar basal-body rod protein 423423 flgB 6333381 flgB Treponema pallidum subsp. pallidum SS14 flagellar basal-body rod protein YP_001933401.1 423013 D 455434 CDS YP_001933402.1 189025630 6333458 423508..423897 1 NC_010741.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 423897 flgC 6333458 flgC Treponema pallidum subsp. pallidum SS14 flagellar basal body rod protein FlgC YP_001933402.1 423508 D 455434 CDS YP_001933403.1 189025631 6333475 423953..424327 1 NC_010741.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE 424327 fliE 6333475 fliE Treponema pallidum subsp. pallidum SS14 flagellar hook-basal body protein FliE YP_001933403.1 423953 D 455434 CDS YP_001933404.1 189025632 6333470 424444..426147 1 NC_010741.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 426147 fliF 6333470 fliF Treponema pallidum subsp. pallidum SS14 flagellar MS-ring protein YP_001933404.1 424444 D 455434 CDS YP_001933405.1 189025633 6333477 426152..427210 1 NC_010741.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 427210 fliG 6333477 fliG Treponema pallidum subsp. pallidum SS14 flagellar motor switch protein G YP_001933405.1 426152 D 455434 CDS YP_001933406.1 189025634 6332980 427258..428187 1 NC_010741.1 binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 428187 fliH 6332980 fliH Treponema pallidum subsp. pallidum SS14 flagellar assembly protein H YP_001933406.1 427258 D 455434 CDS YP_001933407.1 189025635 6333494 428215..429558 1 NC_010741.1 flagellum-specific ATP synthase 429558 fliI 6333494 fliI Treponema pallidum subsp. pallidum SS14 flagellum-specific ATP synthase YP_001933407.1 428215 D 455434 CDS YP_001933408.1 189025636 6333487 429587..430039 1 NC_010741.1 flagellar protein 430039 6333487 TPASS_0403 Treponema pallidum subsp. pallidum SS14 flagellar protein YP_001933408.1 429587 D 455434 CDS YP_001933409.1 189025637 6333523 complement(430036..430569) 1 NC_010741.1 hypothetical protein 430569 6333523 TPASS_0404 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933409.1 430036 R 455434 CDS YP_001933410.1 189025638 6333540 complement(430566..431015) 1 NC_010741.1 protein McbG 431015 6333540 TPASS_0405 Treponema pallidum subsp. pallidum SS14 protein McbG YP_001933410.1 430566 R 455434 CDS YP_001933411.1 189025639 6332997 431206..432012 1 NC_010741.1 glutamate racemase 432012 murI 6332997 murI Treponema pallidum subsp. pallidum SS14 glutamate racemase YP_001933411.1 431206 D 455434 CDS YP_001933412.1 189025640 6333010 432140..432814 1 NC_010741.1 phosphoglycolate phosphatase 432814 gph1 6333010 gph1 Treponema pallidum subsp. pallidum SS14 phosphoglycolate phosphatase YP_001933412.1 432140 D 455434 CDS YP_001933413.1 189025641 6333557 432893..436147 1 NC_010741.1 hypothetical protein 436147 6333557 TPASS_0408 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933413.1 432893 D 455434 CDS YP_001933414.1 189025642 6333542 436187..436372 1 NC_010741.1 hypothetical protein 436372 6333542 TPASS_0409 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933414.1 436187 D 455434 CDS YP_001933415.1 189025643 6333563 436637..438388 1 NC_010741.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 438388 secD 6333563 secD Treponema pallidum subsp. pallidum SS14 preprotein translocase subunit SecD YP_001933415.1 436637 D 455434 CDS YP_001933416.1 189025644 6333614 438385..439647 1 NC_010741.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 439647 secF 6333614 secF Treponema pallidum subsp. pallidum SS14 preprotein translocase subunit SecF YP_001933416.1 438385 D 455434 CDS YP_001933417.1 189025645 6332827 complement(439723..440028) 1 NC_010741.1 hypothetical protein 440028 6332827 TPASS_0412 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933417.1 439723 R 455434 CDS YP_001933418.1 189025646 6333618 complement(440047..441945) 1 NC_010741.1 phosphoglucomutase 441945 6333618 TPASS_0413 Treponema pallidum subsp. pallidum SS14 phosphoglucomutase YP_001933418.1 440047 R 455434 CDS YP_001933419.1 189025647 6333050 442048..443403 1 NC_010741.1 D-alanine glycine permease 443403 dagA 6333050 dagA Treponema pallidum subsp. pallidum SS14 D-alanine glycine permease YP_001933419.1 442048 D 455434 CDS YP_001933420.1 189025648 6333643 443384..443917 1 NC_010741.1 hypothetical protein 443917 6333643 TPASS_0415 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933420.1 443384 D 455434 CDS YP_001933421.1 189025649 6333624 complement(443864..445222) 1 NC_010741.1 signal recognition particle protein 445222 ffh 6333624 ffh Treponema pallidum subsp. pallidum SS14 signal recognition particle protein YP_001933421.1 443864 R 455434 CDS YP_001933422.1 189025650 6333053 complement(445215..446894) 1 NC_010741.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 446894 lnt 6333053 lnt Treponema pallidum subsp. pallidum SS14 apolipoprotein N-acyltransferase YP_001933422.1 445215 R 455434 CDS YP_001933423.1 189025651 6333658 446921..448114 1 NC_010741.1 galactokinase 448114 6333658 TPASS_0418 Treponema pallidum subsp. pallidum SS14 galactokinase YP_001933423.1 446921 D 455434 CDS YP_001933424.1 189025652 6332837 448111..448674 1 NC_010741.1 survival protein 448674 6332837 TPASS_0419 Treponema pallidum subsp. pallidum SS14 survival protein YP_001933424.1 448111 D 455434 CDS YP_001933425.1 189025653 6333654 448655..448882 1 NC_010741.1 hypothetical protein 448882 6333654 TPASS_0420 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933425.1 448655 D 455434 CDS YP_001933426.1 189025654 6333062 449016..451067 1 NC_010741.1 hypothetical protein 451067 6333062 TPASS_0421 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933426.1 449016 D 455434 CDS YP_001933427.1 189025655 6333057 451051..452076 1 NC_010741.1 hypothetical protein 452076 6333057 TPASS_0422 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933427.1 451051 D 455434 CDS YP_001933428.1 189025656 6333060 452101..452907 1 NC_010741.1 hypothetical protein 452907 6333060 TPASS_0423 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933428.1 452101 D 455434 CDS YP_001933429.1 189025657 6333044 453110..453808 1 NC_010741.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the E subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit E 453808 6333044 TPASS_0424 Treponema pallidum subsp. pallidum SS14 V-type ATP synthase subunit E YP_001933429.1 453110 D 455434 CDS YP_001933430.1 189025658 6333623 453786..454046 1 NC_010741.1 hypothetical protein 454046 6333623 TPASS_0425 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933430.1 453786 D 455434 CDS YP_001933431.1 189025659 6333056 454188..455957 1 NC_010741.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the A subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit A 455957 atpA1 6333056 atpA1 Treponema pallidum subsp. pallidum SS14 V-type ATP synthase subunit A YP_001933431.1 454188 D 455434 CDS YP_001933432.1 189025660 6333622 455961..457253 1 NC_010741.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit B 457253 atpB1 6333622 atpB1 Treponema pallidum subsp. pallidum SS14 V-type ATP synthase subunit B YP_001933432.1 455961 D 455434 CDS YP_001933433.1 189025661 6333605 457265..457885 1 NC_010741.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the D subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit D 457885 atpD1 6333605 atpD1 Treponema pallidum subsp. pallidum SS14 V-type ATP synthase subunit D YP_001933433.1 457265 D 455434 CDS YP_001933434.1 189025662 6333608 457882..459750 1 NC_010741.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I is part of the membrane proton channel.; V-type ATP synthase subunit I 459750 atpI1 6333608 atpI1 Treponema pallidum subsp. pallidum SS14 V-type ATP synthase subunit I YP_001933434.1 457882 D 455434 CDS YP_001933435.1 189025663 6333599 459787..460209 1 NC_010741.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits; V-type ATP synthase subunit K 460209 atpK1 6333599 atpK1 Treponema pallidum subsp. pallidum SS14 V-type ATP synthase subunit K YP_001933435.1 459787 D 455434 CDS YP_001933436.1 189025664 6333579 460243..461064 1 NC_010741.1 hypothetical protein 461064 6333579 TPASS_0431 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933436.1 460243 D 455434 CDS YP_001933437.1 189025665 6333022 461107..461658 1 NC_010741.1 hypothetical protein 461658 6333022 TPASS_0432 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933437.1 461107 D 455434 CDS YP_001933438.1 189025666 6333577 461713..463527 1 NC_010741.1 acidic repeat protein 463527 arp 6333577 arp Treponema pallidum subsp. pallidum SS14 acidic repeat protein YP_001933438.1 461713 D 455434 CDS YP_001933439.1 189025667 6333547 complement(463624..464094) 1 NC_010741.1 lipoprotein, 17 kDa 464094 tpp17 6333547 tpp17 Treponema pallidum subsp. pallidum SS14 lipoprotein, 17 kDa YP_001933439.1 463624 R 455434 CDS YP_001933440.1 189025668 6333546 complement(464225..465307) 1 NC_010741.1 hypothetical protein 465307 6333546 TPASS_0436 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933440.1 464225 R 455434 CDS YP_001933441.1 189025669 6333558 complement(465273..465803) 1 NC_010741.1 hypothetical protein 465803 6333558 TPASS_0437 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933441.1 465273 R 455434 CDS YP_001933442.1 189025670 6333091 465833..466642 1 NC_010741.1 hypothetical protein 466642 6333091 TPASS_0438 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933442.1 465833 D 455434 CDS YP_001933443.1 189025671 6333740 466729..467241 1 NC_010741.1 purine-binding chemotaxis protein 467241 cheW2 6333740 cheW2 Treponema pallidum subsp. pallidum SS14 purine-binding chemotaxis protein YP_001933443.1 466729 D 455434 CDS YP_001933444.1 189025672 6333356 467331..468482 1 NC_010741.1 spore coat polysaccharide biosynthesis protein 468482 6333356 TPASS_0440 Treponema pallidum subsp. pallidum SS14 spore coat polysaccharide biosynthesis protein YP_001933444.1 467331 D 455434 CDS YP_001933445.1 189025673 6333698 468479..469396 1 NC_010741.1 hypothetical protein 469396 6333698 TPASS_0441 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933445.1 468479 D 455434 CDS YP_001933446.1 189025674 6333699 469389..471110 1 NC_010741.1 DNA repair protein 471110 recN 6333699 recN Treponema pallidum subsp. pallidum SS14 DNA repair protein YP_001933446.1 469389 D 455434 CDS YP_001933447.1 189025675 6333088 471052..471906 1 NC_010741.1 hypothetical protein 471906 6333088 TPASS_0443 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933447.1 471052 D 455434 CDS YP_001933448.1 189025676 6333752 471912..472940 1 NC_010741.1 hypothetical protein 472940 6333752 TPASS_0444 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933448.1 471912 D 455434 CDS YP_001933449.1 189025677 6333704 473076..473705 1 NC_010741.1 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme 473705 thiJ 6333704 thiJ Treponema pallidum subsp. pallidum SS14 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme YP_001933449.1 473076 D 455434 CDS YP_001933450.1 189025678 6333696 473747..474961 1 NC_010741.1 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 474961 gcpE 6333696 gcpE Treponema pallidum subsp. pallidum SS14 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_001933450.1 473747 D 455434 CDS YP_001933451.1 189025679 6333695 474958..476082 1 NC_010741.1 hypothetical protein 476082 6333695 TPASS_0447 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933451.1 474958 D 455434 CDS YP_001933452.1 189025680 6333087 476140..477222 1 NC_010741.1 uracil phosphoribosyltransferase 477222 6333087 TPASS_0448 Treponema pallidum subsp. pallidum SS14 uracil phosphoribosyltransferase YP_001933452.1 476140 D 455434 CDS YP_001933453.1 189025681 6333086 477226..477816 1 NC_010741.1 hypothetical protein 477816 6333086 TPASS_0449 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933453.1 477226 D 455434 CDS YP_001933454.1 189025682 6333694 477953..480004 1 NC_010741.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 480004 fusA1 6333694 fusA1 Treponema pallidum subsp. pallidum SS14 elongation factor G YP_001933454.1 477953 D 455434 CDS YP_001933455.1 189025683 6333692 complement(479993..480175) 1 NC_010741.1 hypothetical protein 480175 6333692 TPASS_0451 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933455.1 479993 R 455434 CDS YP_001933456.1 189025684 6333693 480454..483729 1 NC_010741.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 483729 ileS 6333693 ileS Treponema pallidum subsp. pallidum SS14 isoleucyl-tRNA synthetase YP_001933456.1 480454 D 455434 CDS YP_001933457.1 189025685 6333093 483716..484579 1 NC_010741.1 hypothetical protein 484579 6333093 TPASS_0453 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933457.1 483716 D 455434 CDS YP_001933458.1 189025686 6332846 complement(484929..485618) 1 NC_010741.1 hypothetical protein 485618 6332846 TPASS_0454 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933458.1 484929 R 455434 CDS YP_001933459.1 189025687 6333085 complement(485615..486619) 1 NC_010741.1 hypothetical protein 486619 6333085 TPASS_0455 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933459.1 485615 R 455434 CDS YP_001933460.1 189025688 6333691 complement(486676..487992) 1 NC_010741.1 hypothetical protein 487992 6333691 TPASS_0456 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933460.1 486676 R 455434 CDS YP_001933461.1 189025689 6333690 488060..489841 1 NC_010741.1 hypothetical protein 489841 6333690 TPASS_0457 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933461.1 488060 D 455434 CDS YP_001933462.1 189025690 6333084 489932..490510 1 NC_010741.1 hypothetical protein 490510 6333084 TPASS_0458 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933462.1 489932 D 455434 CDS YP_001933463.1 189025691 6333689 490539..491324 1 NC_010741.1 hypothetical protein 491324 6333689 TPASS_0459 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933463.1 490539 D 455434 CDS YP_001933464.1 189025692 6333688 491367..492074 1 NC_010741.1 hypothetical protein 492074 6333688 TPASS_0460 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933464.1 491367 D 455434 CDS YP_001933465.1 189025693 6333083 492075..492434 1 NC_010741.1 hypothetical protein 492434 6333083 TPASS_0461 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933465.1 492075 D 455434 CDS YP_001933466.1 189025694 6332845 492639..493481 1 NC_010741.1 hypothetical protein 493481 6332845 TPASS_0462 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933466.1 492639 D 455434 CDS YP_001933467.1 189025695 6333687 493486..493818 1 NC_010741.1 hypothetical protein 493818 6333687 TPASS_0463 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933467.1 493486 D 455434 CDS YP_001933468.1 189025696 6333686 complement(493877..494629) 1 NC_010741.1 hypothetical protein 494629 6333686 TPASS_0464 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933468.1 493877 R 455434 CDS YP_001933469.1 189025697 6333082 complement(494626..495498) 1 NC_010741.1 hypothetical protein 495498 6333082 TPASS_0465 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933469.1 494626 R 455434 CDS YP_001933470.1 189025698 6332844 complement(495431..496600) 1 NC_010741.1 hypothetical protein 496600 6332844 TPASS_0466 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933470.1 495431 R 455434 CDS YP_001933471.1 189025699 6333685 496591..496839 1 NC_010741.1 hypothetical protein 496839 6333685 TPASS_0467 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933471.1 496591 D 455434 CDS YP_001933472.1 189025700 6333027 complement(496809..498761) 1 NC_010741.1 hypothetical protein 498761 6333027 TPASS_0468 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933472.1 496809 R 455434 CDS YP_001933473.1 189025701 6333673 complement(498754..499695) 1 NC_010741.1 hypothetical protein 499695 6333673 TPASS_0470 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933473.1 498754 R 455434 CDS YP_001933474.1 189025702 6333682 499687..501096 1 NC_010741.1 hypothetical protein 501096 6333682 TPASS_0471 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933474.1 499687 D 455434 CDS YP_001933475.1 189025703 6333081 complement(501109..503184) 1 NC_010741.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 503184 uvrC 6333081 uvrC Treponema pallidum subsp. pallidum SS14 excinuclease ABC subunit C YP_001933475.1 501109 R 455434 CDS YP_001933476.1 189025704 6333080 complement(503259..503903) 1 NC_010741.1 hypothetical protein 503903 6333080 TPASS_0473 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933476.1 503259 R 455434 CDS YP_001933477.1 189025705 6333683 complement(503968..504705) 1 NC_010741.1 hypothetical protein 504705 6333683 TPASS_0474 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933477.1 503968 R 455434 CDS YP_001933478.1 189025706 6333079 complement(504846..506453) 1 NC_010741.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 506453 pgi 6333079 pgi Treponema pallidum subsp. pallidum SS14 glucose-6-phosphate isomerase YP_001933478.1 504846 R 455434 CDS YP_001933479.1 189025707 6333364 complement(506517..507863) 1 NC_010741.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 507863 ack 6333364 ack Treponema pallidum subsp. pallidum SS14 acetate kinase YP_001933479.1 506517 R 455434 CDS YP_001933480.1 189025708 6333681 complement(507930..508655) 1 NC_010741.1 glucose-6-phosphate 1-dehydrogenase 508655 6333681 TPASS_0477 Treponema pallidum subsp. pallidum SS14 glucose-6-phosphate 1-dehydrogenase YP_001933480.1 507930 R 455434 CDS YP_001933481.1 189025709 6333679 complement(508716..510263) 1 NC_010741.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 510263 zwf 6333679 zwf Treponema pallidum subsp. pallidum SS14 glucose-6-phosphate 1-dehydrogenase YP_001933481.1 508716 R 455434 CDS YP_001933482.1 189025710 6333680 complement(510336..511010) 1 NC_010741.1 hypothetical protein 511010 6333680 TPASS_0479 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933482.1 510336 R 455434 CDS YP_001933483.1 189025711 6333078 511122..511610 1 NC_010741.1 hypothetical protein 511610 6333078 TPASS_0480 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933483.1 511122 D 455434 CDS YP_001933484.1 189025712 6333106 511642..513075 1 NC_010741.1 hypothetical protein 513075 6333106 TPASS_0481 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933484.1 511642 D 455434 CDS YP_001933485.1 189025713 6333677 513042..513890 1 NC_010741.1 hypothetical protein 513890 6333677 TPASS_0482 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933485.1 513042 D 455434 CDS YP_001933486.1 189025714 6333706 complement(513956..515080) 1 NC_010741.1 fibronectin-binding protein 515080 6333706 TPASS_0483 Treponema pallidum subsp. pallidum SS14 fibronectin-binding protein YP_001933486.1 513956 R 455434 CDS YP_001933487.1 189025715 6333678 complement(515067..517082) 1 NC_010741.1 hypothetical protein 517082 6333678 TPASS_0484 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933487.1 515067 R 455434 CDS YP_001933488.1 189025716 6332842 complement(516976..518820) 1 NC_010741.1 adenylate cyclase 518820 6332842 TPASS_0485 Treponema pallidum subsp. pallidum SS14 adenylate cyclase YP_001933488.1 516976 R 455434 CDS YP_001933489.1 189025717 6333076 complement(518817..520412) 1 NC_010741.1 antigen, p83/100 520412 6333076 TPASS_0486 Treponema pallidum subsp. pallidum SS14 antigen, p83/100 YP_001933489.1 518817 R 455434 CDS YP_001933490.1 189025718 6333676 complement(520501..522078) 1 NC_010741.1 hypothetical protein 522078 6333676 TPASS_0487 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933490.1 520501 R 455434 CDS YP_001933491.1 189025719 6333075 522306..524843 1 NC_010741.1 methyl-accepting chemotaxis protein 524843 mcp2 6333075 mcp2 Treponema pallidum subsp. pallidum SS14 methyl-accepting chemotaxis protein YP_001933491.1 522306 D 455434 CDS YP_001933492.1 189025720 6333074 525291..526259 1 NC_010741.1 hypothetical protein 526259 6333074 TPASS_0489 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933492.1 525291 D 455434 CDS YP_001933493.1 189025721 6333758 526256..526444 1 NC_010741.1 hypothetical protein 526444 6333758 TPASS_0490 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933493.1 526256 D 455434 CDS YP_001933494.1 189025722 6333714 526451..527485 1 NC_010741.1 hypothetical protein 527485 6333714 TPASS_0491 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933494.1 526451 D 455434 CDS YP_001933495.1 189025723 6332840 527509..529326 1 NC_010741.1 DNA primase 529326 dnaG 6332840 dnaG Treponema pallidum subsp. pallidum SS14 DNA primase YP_001933495.1 527509 D 455434 CDS YP_001933496.1 189025724 6333097 529323..531158 1 NC_010741.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 531158 rpoD 6333097 rpoD Treponema pallidum subsp. pallidum SS14 RNA polymerase sigma factor RpoD YP_001933496.1 529323 D 455434 CDS YP_001933497.1 189025725 6332850 531168..531989 1 NC_010741.1 hypothetical protein 531989 6332850 TPASS_0494 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933497.1 531168 D 455434 CDS YP_001933498.1 189025726 6333713 532319..533308 1 NC_010741.1 hypothetical protein 533308 6333713 TPASS_0496 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933498.1 532319 D 455434 CDS YP_001933499.1 189025727 6333096 533321..534355 1 NC_010741.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 534355 mreB 6333096 mreB Treponema pallidum subsp. pallidum SS14 rod shape-determining protein MreB YP_001933499.1 533321 D 455434 CDS YP_001933500.1 189025728 6333095 534360..535223 1 NC_010741.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 535223 mreC 6333095 mreC Treponema pallidum subsp. pallidum SS14 rod shape-determining protein MreC YP_001933500.1 534360 D 455434 CDS YP_001933501.1 189025729 6333711 535220..535726 1 NC_010741.1 rod shape-determining protein 535726 mreD 6333711 mreD Treponema pallidum subsp. pallidum SS14 rod shape-determining protein YP_001933501.1 535220 D 455434 CDS YP_001933502.1 189025730 6333710 535727..537601 1 NC_010741.1 penicillin-binding protein 537601 pbp1 6333710 pbp1 Treponema pallidum subsp. pallidum SS14 penicillin-binding protein YP_001933502.1 535727 D 455434 CDS YP_001933503.1 189025731 6333712 537598..538899 1 NC_010741.1 rod shape-determining protein 538899 rodA 6333712 rodA Treponema pallidum subsp. pallidum SS14 rod shape-determining protein YP_001933503.1 537598 D 455434 CDS YP_001933504.1 189025732 6333709 538925..539821 1 NC_010741.1 hypothetical protein 539821 6333709 TPASS_0502 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933504.1 538925 D 455434 CDS YP_001933505.1 189025733 6332849 539800..540363 1 NC_010741.1 hypothetical protein 540363 6332849 TPASS_0503 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933505.1 539800 D 455434 CDS YP_001933506.1 189025734 6333708 540345..540485 1 NC_010741.1 hypothetical protein 540485 6333708 TPASS_0504 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933506.1 540345 D 455434 CDS YP_001933507.1 189025735 6333707 complement(540494..541828) 1 NC_010741.1 hexokinase 541828 hxk 6333707 hxk Treponema pallidum subsp. pallidum SS14 hexokinase YP_001933507.1 540494 R 455434 CDS YP_001933508.1 189025736 6333760 542563..543891 1 NC_010741.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 543891 tig 6333760 tig Treponema pallidum subsp. pallidum SS14 trigger factor YP_001933508.1 542563 D 455434 CDS YP_001933509.1 189025737 6333715 543884..544495 1 NC_010741.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 544495 clpP 6333715 clpP Treponema pallidum subsp. pallidum SS14 ATP-dependent Clp protease proteolytic subunit YP_001933509.1 543884 D 455434 CDS YP_001933510.1 189025738 6333098 544482..545729 1 NC_010741.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 545729 clpX 6333098 clpX Treponema pallidum subsp. pallidum SS14 ATP-dependent protease ATP-binding subunit ClpX YP_001933510.1 544482 D 455434 CDS YP_001933511.1 189025739 6332851 545826..546392 1 NC_010741.1 alkyl hydroperoxide reductase 546392 ahpC 6332851 ahpC Treponema pallidum subsp. pallidum SS14 alkyl hydroperoxide reductase YP_001933511.1 545826 D 455434 CDS YP_001933512.1 189025740 6333071 complement(546573..548390) 1 NC_010741.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 548390 lepA 6333071 lepA Treponema pallidum subsp. pallidum SS14 GTP-binding protein LepA YP_001933512.1 546573 R 455434 CDS YP_001933513.1 189025741 6333668 548433..549059 1 NC_010741.1 transcription factor 549059 carD 6333668 carD Treponema pallidum subsp. pallidum SS14 transcription factor YP_001933513.1 548433 D 455434 CDS YP_001933514.1 189025742 6333669 549056..550303 1 NC_010741.1 hypothetical protein 550303 6333669 TPASS_0512 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933514.1 549056 D 455434 CDS YP_001933515.1 189025743 6333362 550377..551777 1 NC_010741.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 551777 trkA 6333362 trkA Treponema pallidum subsp. pallidum SS14 potassium transporter peripheral membrane component YP_001933515.1 550377 D 455434 CDS YP_001933516.1 189025744 6333670 551891..554773 1 NC_010741.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 554773 uvrA 6333670 uvrA Treponema pallidum subsp. pallidum SS14 excinuclease ABC subunit A YP_001933516.1 551891 D 455434 CDS YP_001933517.1 189025745 6333671 554770..557745 1 NC_010741.1 hypothetical protein 557745 6333671 TPASS_0515 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933517.1 554770 D 455434 CDS YP_001933518.1 189025746 6333729 complement(557759..559339) 1 NC_010741.1 virulence factor 559339 mviN 6333729 mviN Treponema pallidum subsp. pallidum SS14 virulence factor YP_001933518.1 557759 R 455434 CDS YP_001933519.1 189025747 6332839 complement(559336..559926) 1 NC_010741.1 Holliday junction nuclease, subunit C 559926 ruvC 6332839 ruvC Treponema pallidum subsp. pallidum SS14 Holliday junction nuclease, subunit C YP_001933519.1 559336 R 455434 CDS YP_001933520.1 189025748 6333730 complement(559908..560600) 1 NC_010741.1 hypothetical protein 560600 6333730 TPASS_0518 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933520.1 559908 R 455434 CDS YP_001933521.1 189025749 6333724 complement(560597..561973) 1 NC_010741.1 response regulatory protein 561973 atoC 6333724 atoC Treponema pallidum subsp. pallidum SS14 response regulatory protein YP_001933521.1 560597 R 455434 CDS YP_001933522.1 189025750 6333726 complement(563168..564439) 1 NC_010741.1 DNA polymerase III, gamma and tau subunits 564439 6333726 TPASS_0521 Treponema pallidum subsp. pallidum SS14 DNA polymerase III, gamma and tau subunits YP_001933522.1 563168 R 455434 CDS YP_001933523.1 189025751 6332853 complement(564450..564929) 1 NC_010741.1 hypothetical protein 564929 6332853 TPASS_0522 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933523.1 564450 R 455434 CDS YP_001933524.1 189025752 6333684 complement(564926..566080) 1 NC_010741.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 566080 murG 6333684 murG Treponema pallidum subsp. pallidum SS14 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_001933524.1 564926 R 455434 CDS YP_001933525.1 189025753 6333104 complement(566084..568729) 1 NC_010741.1 ATP-dependent protease LA 568729 lon2 6333104 lon2 Treponema pallidum subsp. pallidum SS14 ATP-dependent protease LA YP_001933525.1 566084 R 455434 CDS YP_001933526.1 189025754 6333725 568865..569428 1 NC_010741.1 translation elongation factor P 569428 efp 6333725 efp Treponema pallidum subsp. pallidum SS14 translation elongation factor P YP_001933526.1 568865 D 455434 CDS YP_001933527.1 189025755 6333101 569576..571582 1 NC_010741.1 ATP-dependent helicase 571582 hrpA 6333101 hrpA Treponema pallidum subsp. pallidum SS14 ATP-dependent helicase YP_001933527.1 569576 D 455434 CDS YP_001933528.1 189025756 6333720 complement(571630..572259) 1 NC_010741.1 V-type ATPase, subunit D 572259 atpD2 6333720 atpD2 Treponema pallidum subsp. pallidum SS14 V-type ATPase, subunit D YP_001933528.1 571630 R 455434 CDS YP_001933529.1 189025757 6333723 complement(572354..573796) 1 NC_010741.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit B 573796 atpB2 6333723 atpB2 Treponema pallidum subsp. pallidum SS14 V-type ATP synthase subunit B YP_001933529.1 572354 R 455434 CDS YP_001933530.1 189025758 6333722 complement(573793..575610) 1 NC_010741.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the A subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit A 575610 atpA2 6333722 atpA2 Treponema pallidum subsp. pallidum SS14 V-type ATP synthase subunit A YP_001933530.1 573793 R 455434 CDS YP_001933531.1 189025759 6332863 complement(575607..576233) 1 NC_010741.1 V-type ATPase, subunit E 576233 6332863 TPASS_0530 Treponema pallidum subsp. pallidum SS14 V-type ATPase, subunit E YP_001933531.1 575607 R 455434 CDS YP_001933532.1 189025760 6333721 complement(576239..576577) 1 NC_010741.1 V-type ATPase, subunit F 576577 6333721 TPASS_0531 Treponema pallidum subsp. pallidum SS14 V-type ATPase, subunit F YP_001933532.1 576239 R 455434 CDS YP_001933533.1 189025761 6332848 complement(577197..578561) 1 NC_010741.1 V-type ATPase, subunit I 578561 atpI2 6332848 atpI2 Treponema pallidum subsp. pallidum SS14 V-type ATPase, subunit I YP_001933533.1 577197 R 455434 CDS YP_001933534.1 189025762 6333737 complement(578554..579579) 1 NC_010741.1 hypothetical protein 579579 6333737 TPASS_0534 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933534.1 578554 R 455434 CDS YP_001933535.1 189025763 6333736 complement(579583..579795) 1 NC_010741.1 hypothetical protein 579795 6333736 TPASS_0535 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933535.1 579583 R 455434 CDS YP_001933536.1 189025764 6333735 complement(579936..580337) 1 NC_010741.1 preprotein translocase subunit SecG 580337 secG 6333735 secG Treponema pallidum subsp. pallidum SS14 preprotein translocase subunit SecG YP_001933536.1 579936 R 455434 CDS YP_001933537.1 189025765 6333109 complement(580487..581236) 1 NC_010741.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 581236 tpiA 6333109 tpiA Treponema pallidum subsp. pallidum SS14 triosephosphate isomerase YP_001933537.1 580487 R 455434 CDS YP_001933538.1 189025766 6332857 complement(581387..582646) 1 NC_010741.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 582646 pgk 6332857 pgk Treponema pallidum subsp. pallidum SS14 phosphoglycerate kinase YP_001933538.1 581387 R 455434 CDS YP_001933539.1 189025767 6333738 582618..582839 1 NC_010741.1 hypothetical protein 582839 6333738 TPASS_0539 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933539.1 582618 D 455434 CDS YP_001933540.1 189025768 6333114 583120..583491 1 NC_010741.1 anti-sigma F factor antagonist 583491 spoIIAA2 6333114 spoIIAA2 Treponema pallidum subsp. pallidum SS14 anti-sigma F factor antagonist YP_001933540.1 583120 D 455434 CDS YP_001933541.1 189025769 6333553 583621..584580 1 NC_010741.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 584580 era 6333553 era Treponema pallidum subsp. pallidum SS14 GTP-binding protein Era YP_001933541.1 583621 D 455434 CDS YP_001933542.1 189025770 6333733 complement(584577..586298) 1 NC_010741.1 catalyzes the formation of fructose 1,6-bisphosphate from fructose 6-phosphate and diphosphate; diphosphate--fructose-6-phosphate 1-phosphotransferase 586298 6333733 TPASS_0542 Treponema pallidum subsp. pallidum SS14 diphosphate--fructose-6-phosphate 1-phosphotransferase YP_001933542.1 584577 R 455434 CDS YP_001933543.1 189025771 6333732 complement(586358..587041) 1 NC_010741.1 Holliday junction DNA helicase, subunit A 587041 ruvA 6333732 ruvA Treponema pallidum subsp. pallidum SS14 Holliday junction DNA helicase, subunit A YP_001933543.1 586358 R 455434 CDS YP_001933544.1 189025772 6332856 complement(587083..588957) 1 NC_010741.1 hypothetical protein 588957 6332856 TPASS_0544 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933544.1 587083 R 455434 CDS YP_001933545.1 189025773 6333734 complement(588982..590046) 1 NC_010741.1 methylgalactoside ABC transporter, periplasmic galactose-binding protein 590046 mglB1 6333734 mglB1 Treponema pallidum subsp. pallidum SS14 methylgalactoside ABC transporter, periplasmic galactose-binding protein YP_001933545.1 588982 R 455434 CDS YP_001933546.1 189025774 6333108 complement(590131..592131) 1 NC_010741.1 periplasmic serine protease 592131 6333108 TPASS_0546 Treponema pallidum subsp. pallidum SS14 periplasmic serine protease YP_001933546.1 590131 R 455434 CDS YP_001933547.1 189025775 6333105 complement(591843..592973) 1 NC_010741.1 penicillin tolerance protein 592973 lytB 6333105 lytB Treponema pallidum subsp. pallidum SS14 penicillin tolerance protein YP_001933547.1 591843 R 455434 CDS YP_001933548.1 189025776 6333092 593117..594433 1 NC_010741.1 hypothetical protein 594433 6333092 TPASS_0548 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933548.1 593117 D 455434 CDS YP_001933549.1 189025777 6333731 594531..596975 1 NC_010741.1 ATP-dependent Clp protease, subunit C 596975 clpC 6333731 clpC Treponema pallidum subsp. pallidum SS14 ATP-dependent Clp protease, subunit C YP_001933549.1 594531 D 455434 CDS YP_001933550.1 189025778 6333727 complement(597016..598503) 1 NC_010741.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 598503 trmE 6333727 trmE Treponema pallidum subsp. pallidum SS14 tRNA modification GTPase TrmE YP_001933550.1 597016 R 455434 CDS YP_001933551.1 189025779 6333077 complement(598507..599595) 1 NC_010741.1 phosphatase 599595 6333077 TPASS_0551 Treponema pallidum subsp. pallidum SS14 phosphatase YP_001933551.1 598507 R 455434 CDS YP_001933552.1 189025780 6333728 complement(599608..600141) 1 NC_010741.1 hypothetical protein 600141 6333728 TPASS_0552 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933552.1 599608 R 455434 CDS YP_001933553.1 189025781 6332854 600385..601596 1 NC_010741.1 hypothetical protein 601596 6332854 TPASS_0553 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933553.1 600385 D 455434 CDS YP_001933554.1 189025782 6333697 601631..602299 1 NC_010741.1 phosphoglycolate phosphatase 602299 gph2 6333697 gph2 Treponema pallidum subsp. pallidum SS14 phosphoglycolate phosphatase YP_001933554.1 601631 D 455434 CDS YP_001933555.1 189025783 6333753 complement(602363..603553) 1 NC_010741.1 glutamate/aspartate transporter 603553 6333753 TPASS_0555 Treponema pallidum subsp. pallidum SS14 glutamate/aspartate transporter YP_001933555.1 602363 R 455434 CDS YP_001933556.1 189025784 6333117 complement(603776..604768) 1 NC_010741.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 604768 asnA 6333117 asnA Treponema pallidum subsp. pallidum SS14 asparagine synthetase AsnA YP_001933556.1 603776 R 455434 CDS YP_001933557.1 189025785 6333748 604873..605586 1 NC_010741.1 hypothetical protein 605586 6333748 TPASS_0557 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933557.1 604873 D 455434 CDS YP_001933558.1 189025786 6333675 605616..606524 1 NC_010741.1 hypothetical protein 606524 6333675 TPASS_0558 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933558.1 605616 D 455434 CDS YP_001933559.1 189025787 6333750 606586..607791 1 NC_010741.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 607791 6333750 TPASS_0559 Treponema pallidum subsp. pallidum SS14 thiamine biosynthesis protein ThiI YP_001933559.1 606586 D 455434 CDS YP_001933560.1 189025788 6333751 complement(607844..609829) 1 NC_010741.1 transketolase A 609829 tktA 6333751 tktA Treponema pallidum subsp. pallidum SS14 transketolase A YP_001933560.1 607844 R 455434 CDS YP_001933561.1 189025789 6332860 complement(609940..610791) 1 NC_010741.1 hypothetical protein 610791 6332860 TPASS_0561 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933561.1 609940 R 455434 CDS YP_001933562.1 189025790 6333178 610962..612098 1 NC_010741.1 spore coat polysaccharide biosynthesis protein 612098 spsE 6333178 spsE Treponema pallidum subsp. pallidum SS14 spore coat polysaccharide biosynthesis protein YP_001933562.1 610962 D 455434 CDS YP_001933563.1 189025791 6333116 612089..612502 1 NC_010741.1 hypothetical protein 612502 6333116 TPASS_0563 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933563.1 612089 D 455434 CDS YP_001933564.1 189025792 6332855 612499..614535 1 NC_010741.1 hypothetical protein 614535 6332855 TPASS_0564 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933564.1 612499 D 455434 CDS YP_001933565.1 189025793 6333702 complement(614417..615637) 1 NC_010741.1 hypothetical protein 615637 6333702 TPASS_0565 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933565.1 614417 R 455434 CDS YP_001933566.1 189025794 6333235 complement(615648..617135) 1 NC_010741.1 alginate O-acetylation protein 617135 algI 6333235 algI Treponema pallidum subsp. pallidum SS14 alginate O-acetylation protein YP_001933566.1 615648 R 455434 CDS YP_001933567.1 189025795 6333260 complement(617167..617787) 1 NC_010741.1 hypothetical protein 617787 6333260 TPASS_0567 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933567.1 617167 R 455434 CDS YP_001933568.1 189025796 6333270 complement(617866..618498) 1 NC_010741.1 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase 618498 eda 6333270 eda Treponema pallidum subsp. pallidum SS14 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxyphosphogluconate aldolase YP_001933568.1 617866 R 455434 CDS YP_001933569.1 189025797 6333317 complement(618620..620944) 1 NC_010741.1 aminopeptidase P 620944 6333317 TPASS_0569 Treponema pallidum subsp. pallidum SS14 aminopeptidase P YP_001933569.1 618620 R 455434 CDS YP_001933570.1 189025798 6333861 complement(620969..621814) 1 NC_010741.1 hypothetical protein 621814 6333861 TPASS_0570 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933570.1 620969 R 455434 CDS YP_001933571.1 189025799 6333250 complement(621841..622506) 1 NC_010741.1 protein Tp70 622506 6333250 TPASS_0571 Treponema pallidum subsp. pallidum SS14 protein Tp70 YP_001933571.1 621841 R 455434 CDS YP_001933572.1 189025800 6332874 complement(622524..623606) 1 NC_010741.1 hypothetical protein 623606 6332874 TPASS_0572 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933572.1 622524 R 455434 CDS YP_001933573.1 189025801 6333210 623597..623689 1 NC_010741.1 hypothetical protein 623689 6333210 TPASS_0573 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933573.1 623597 D 455434 CDS YP_001933574.1 189025802 6333739 complement(623716..625020) 1 NC_010741.1 carboxypeptidase, 47 kDa 625020 6333739 TPASS_0574 Treponema pallidum subsp. pallidum SS14 carboxypeptidase, 47 kDa YP_001933574.1 623716 R 455434 CDS YP_001933575.1 189025803 6333305 627252..628358 1 NC_010741.1 peptide chain release factor 2 628358 prfB 6333305 prfB Treponema pallidum subsp. pallidum SS14 peptide chain release factor 2 YP_001933575.1 627252 D 455434 CDS YP_001933576.1 189025804 6333327 628250..630094 1 NC_010741.1 hypothetical protein 630094 6333327 TPASS_0577 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933576.1 628250 D 455434 CDS YP_001933577.1 189025805 6332789 630101..630988 1 NC_010741.1 cell division protein 630988 ftsY 6332789 ftsY Treponema pallidum subsp. pallidum SS14 cell division protein YP_001933577.1 630101 D 455434 CDS YP_001933578.1 189025806 6333325 630985..631761 1 NC_010741.1 hypothetical protein 631761 6333325 TPASS_0579 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933578.1 630985 D 455434 CDS YP_001933579.1 189025807 6333280 631754..633043 1 NC_010741.1 hypothetical protein 633043 6333280 TPASS_0580 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933579.1 631754 D 455434 CDS YP_001933580.1 189025808 6333295 633036..633716 1 NC_010741.1 ABC transporter, ATP-binding protein 633716 6333295 TPASS_0581 Treponema pallidum subsp. pallidum SS14 ABC transporter, ATP-binding protein YP_001933580.1 633036 D 455434 CDS YP_001933581.1 189025809 6333797 633713..635200 1 NC_010741.1 hypothetical protein 635200 6333797 TPASS_0582 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933581.1 633713 D 455434 CDS YP_001933582.1 189025810 6333238 complement(635184..635309) 1 NC_010741.1 hypothetical protein 635309 6333238 TPASS_0583 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933582.1 635184 R 455434 CDS YP_001933583.1 189025811 6332905 635296..636705 1 NC_010741.1 hypothetical protein 636705 6332905 TPASS_0584 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933583.1 635296 D 455434 CDS YP_001933584.1 189025812 6333151 636698..638341 1 NC_010741.1 oligopeptide ABC transporter, periplasmic binding protein 638341 oppA 6333151 oppA Treponema pallidum subsp. pallidum SS14 oligopeptide ABC transporter, periplasmic binding protein YP_001933584.1 636698 D 455434 CDS YP_001933585.1 189025813 6333359 638430..641066 1 NC_010741.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 641066 leuS 6333359 leuS Treponema pallidum subsp. pallidum SS14 leucyl-tRNA synthetase YP_001933585.1 638430 D 455434 CDS YP_001933586.1 189025814 6333112 complement(641046..641276) 1 NC_010741.1 hypothetical protein 641276 6333112 TPASS_0587 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933586.1 641046 R 455434 CDS YP_001933587.1 189025815 6333269 complement(641303..642067) 1 NC_010741.1 hypothetical protein 642067 6333269 TPASS_0588 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933587.1 641303 R 455434 CDS YP_001933588.1 189025816 6333323 complement(642155..642421) 1 NC_010741.1 phosphocarrier protein HPr 642421 ptsH 6333323 ptsH Treponema pallidum subsp. pallidum SS14 phosphocarrier protein HPr YP_001933588.1 642155 R 455434 CDS YP_001933589.1 189025817 6333322 complement(642393..642509) 1 NC_010741.1 hypothetical protein 642509 6333322 TPASS_0590 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933589.1 642393 R 455434 CDS YP_001933590.1 189025818 6333315 complement(642466..643425) 1 NC_010741.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 643425 ptsK 6333315 ptsK Treponema pallidum subsp. pallidum SS14 HPr kinase/phosphorylase YP_001933590.1 642466 R 455434 CDS YP_001933591.1 189025819 6332921 644188..645690 1 NC_010741.1 hypothetical protein 645690 6332921 TPASS_0592 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933591.1 644188 D 455434 CDS YP_001933592.1 189025820 6333318 645627..647660 1 NC_010741.1 hypothetical protein 647660 6333318 TPASS_0593 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933592.1 645627 D 455434 CDS YP_001933593.1 189025821 6333353 complement(647747..648355) 1 NC_010741.1 hypothetical protein 648355 6333353 TPASS_0594 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933593.1 647747 R 455434 CDS YP_001933594.1 189025822 6333349 complement(648383..649018) 1 NC_010741.1 adenylate kinase 649018 adk 6333349 adk Treponema pallidum subsp. pallidum SS14 adenylate kinase YP_001933594.1 648383 R 455434 CDS YP_001933595.1 189025823 6333332 complement(649042..650154) 1 NC_010741.1 polynucleotide adenylyltransferase 650154 pcnB 6333332 pcnB Treponema pallidum subsp. pallidum SS14 polynucleotide adenylyltransferase YP_001933595.1 649042 R 455434 CDS YP_001933596.1 189025824 6333594 complement(650262..652325) 1 NC_010741.1 hypothetical protein 652325 6333594 TPASS_0598 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933596.1 650262 R 455434 CDS YP_001933597.1 189025825 6333138 complement(652362..653018) 1 NC_010741.1 hypothetical protein 653018 6333138 TPASS_0599 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933597.1 652362 R 455434 CDS YP_001933598.1 189025826 6333215 complement(653025..654377) 1 NC_010741.1 zinc protease 654377 6333215 TPASS_0600 Treponema pallidum subsp. pallidum SS14 zinc protease YP_001933598.1 653025 R 455434 CDS YP_001933599.1 189025827 6332920 complement(654374..655525) 1 NC_010741.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 655525 dxr 6332920 dxr Treponema pallidum subsp. pallidum SS14 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_001933599.1 654374 R 455434 CDS YP_001933600.1 189025828 6333123 complement(655501..656364) 1 NC_010741.1 phosphatidate cytidylyltransferase 656364 cdsA 6333123 cdsA Treponema pallidum subsp. pallidum SS14 phosphatidate cytidylyltransferase YP_001933600.1 655501 R 455434 CDS YP_001933601.1 189025829 6333248 complement(656361..657047) 1 NC_010741.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 657047 6333248 TPASS_0603 Treponema pallidum subsp. pallidum SS14 undecaprenyl pyrophosphate synthase YP_001933601.1 656361 R 455434 CDS YP_001933602.1 189025830 6333672 complement(657053..657604) 1 NC_010741.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 657604 frr 6333672 frr Treponema pallidum subsp. pallidum SS14 ribosome recycling factor YP_001933602.1 657053 R 455434 CDS YP_001933603.1 189025831 6333251 complement(657708..658580) 1 NC_010741.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 658580 tsf 6333251 tsf Treponema pallidum subsp. pallidum SS14 elongation factor Ts YP_001933603.1 657708 R 455434 CDS YP_001933604.1 189025832 6333308 complement(658671..659546) 1 NC_010741.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 659546 rpsB 6333308 rpsB Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S2 YP_001933604.1 658671 R 455434 CDS YP_001933605.1 189025833 6333304 complement(659515..659661) 1 NC_010741.1 hypothetical protein 659661 6333304 TPASS_0607 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933605.1 659515 R 455434 CDS YP_001933606.1 189025834 6333867 complement(659911..660801) 1 NC_010741.1 hypothetical protein 660801 6333867 TPASS_0608 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933606.1 659911 R 455434 CDS YP_001933607.1 189025835 6333749 661119..662690 1 NC_010741.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 662690 asnC 6333749 asnC Treponema pallidum subsp. pallidum SS14 asparaginyl-tRNA synthetase YP_001933607.1 661119 D 455434 CDS YP_001933608.1 189025836 6333207 662700..664781 1 NC_010741.1 protein TprH 664781 tprH 6333207 tprH Treponema pallidum subsp. pallidum SS14 protein TprH YP_001933608.1 662700 D 455434 CDS YP_001933609.1 189025837 6333703 664923..665702 1 NC_010741.1 ABC transporter, ATP-binding protein 665702 6333703 TPASS_0611 Treponema pallidum subsp. pallidum SS14 ABC transporter, ATP-binding protein YP_001933609.1 664923 D 455434 CDS YP_001933610.1 189025838 6333155 665783..667222 1 NC_010741.1 hypothetical protein 667222 6333155 TPASS_0612 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933610.1 665783 D 455434 CDS YP_001933611.1 189025839 6333336 667249..668397 1 NC_010741.1 hypothetical protein 668397 6333336 TPASS_0613 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933611.1 667249 D 455434 CDS YP_001933612.1 189025840 6333355 668394..669608 1 NC_010741.1 nitrogen fixation protein 669608 nifS1 6333355 nifS1 Treponema pallidum subsp. pallidum SS14 nitrogen fixation protein YP_001933612.1 668394 D 455434 CDS YP_001933613.1 189025841 6333228 669659..670102 1 NC_010741.1 nitrogen fixation protein 670102 nifU 6333228 nifU Treponema pallidum subsp. pallidum SS14 nitrogen fixation protein YP_001933613.1 669659 D 455434 CDS YP_001933614.1 189025842 6333276 670123..670887 1 NC_010741.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 670887 rpiA 6333276 rpiA Treponema pallidum subsp. pallidum SS14 ribose-5-phosphate isomerase A YP_001933614.1 670123 D 455434 CDS YP_001933615.1 189025843 6333229 complement(670914..671192) 1 NC_010741.1 hypothetical protein 671192 6333229 TPASS_0617 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933615.1 670914 R 455434 CDS YP_001933616.1 189025844 6332796 complement(671288..671647) 1 NC_010741.1 hypothetical protein 671647 6332796 TPASS_0618 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933616.1 671288 R 455434 CDS YP_001933617.1 189025845 6333792 complement(671703..672515) 1 NC_010741.1 hypothetical protein 672515 6333792 TPASS_0619 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933617.1 671703 R 455434 CDS YP_001933618.1 189025846 6333289 complement(672512..674341) 1 NC_010741.1 protein TprI 674341 tprI 6333289 tprI Treponema pallidum subsp. pallidum SS14 protein TprI YP_001933618.1 672512 R 455434 CDS YP_001933619.1 189025847 6332861 complement(674399..676675) 1 NC_010741.1 protein TprJ 676675 tprJ 6332861 tprJ Treponema pallidum subsp. pallidum SS14 protein TprJ YP_001933619.1 674399 R 455434 CDS YP_001933620.1 189025848 6332909 complement(676735..678516) 1 NC_010741.1 hypothetical protein 678516 6332909 TPASS_0622 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933620.1 676735 R 455434 CDS YP_001933621.1 189025849 6333227 677933..680272 1 NC_010741.1 membrane-bound lytic murein transglycosylase D 680272 dniR 6333227 dniR Treponema pallidum subsp. pallidum SS14 membrane-bound lytic murein transglycosylase D YP_001933621.1 677933 D 455434 CDS YP_001933622.1 189025850 6332843 680276..681706 1 NC_010741.1 hypothetical protein 681706 6332843 TPASS_0624 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933622.1 680276 D 455434 CDS YP_001933623.1 189025851 6333262 681706..682458 1 NC_010741.1 hypothetical protein 682458 6333262 TPASS_0625 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933623.1 681706 D 455434 CDS YP_001933624.1 189025852 6333320 682455..683630 1 NC_010741.1 exonuclease 683630 6333320 TPASS_0626 Treponema pallidum subsp. pallidum SS14 exonuclease YP_001933624.1 682455 D 455434 CDS YP_001933625.1 189025853 6333274 683627..686770 1 NC_010741.1 exonuclease 686770 sbcC 6333274 sbcC Treponema pallidum subsp. pallidum SS14 exonuclease YP_001933625.1 683627 D 455434 CDS YP_001933626.1 189025854 6333346 686767..688248 1 NC_010741.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 688248 6333346 TPASS_0628 Treponema pallidum subsp. pallidum SS14 nicotinate phosphoribosyltransferase YP_001933626.1 686767 D 455434 CDS YP_001933627.1 189025855 6332914 688419..689243 1 NC_010741.1 hypothetical protein 689243 6332914 TPASS_0629 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933627.1 688419 D 455434 CDS YP_001933628.1 189025856 6333870 689413..690324 1 NC_010741.1 chemotaxis protein methyltransferase 690324 cheR 6333870 cheR Treponema pallidum subsp. pallidum SS14 chemotaxis protein methyltransferase YP_001933628.1 689413 D 455434 CDS YP_001933629.1 189025857 6333186 690371..691582 1 NC_010741.1 protein-glutamate methylesterase 691582 cheB 6333186 cheB Treponema pallidum subsp. pallidum SS14 protein-glutamate methylesterase YP_001933629.1 690371 D 455434 CDS YP_001933630.1 189025858 6333360 691687..692700 1 NC_010741.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 692700 trpS 6333360 trpS Treponema pallidum subsp. pallidum SS14 tryptophanyl-tRNA synthetase YP_001933630.1 691687 D 455434 CDS YP_001933631.1 189025859 6333103 692841..693716 1 NC_010741.1 this fusion consists of methionine sulfoxide B reductase at the N-terminus and A at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion protein of these enzymes with thioredoxin provides protection against oxidative stress in Neisseria gonorrhoeae; bifunctional methionine sulfoxide reductase B/A protein 693716 msrA 6333103 msrA Treponema pallidum subsp. pallidum SS14 bifunctional methionine sulfoxide reductase B/A protein YP_001933631.1 692841 D 455434 CDS YP_001933632.1 189025860 6332895 693835..696306 1 NC_010741.1 DNA ligase 696306 lig 6332895 lig Treponema pallidum subsp. pallidum SS14 DNA ligase YP_001933632.1 693835 D 455434 CDS YP_001933633.1 189025861 6332923 complement(696341..697111) 1 NC_010741.1 hypothetical protein 697111 6332923 TPASS_0636 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933633.1 696341 R 455434 CDS YP_001933634.1 189025862 6333310 complement(697149..698099) 1 NC_010741.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 698099 miaA 6333310 miaA Treponema pallidum subsp. pallidum SS14 tRNA delta(2)-isopentenylpyrophosphate transferase YP_001933634.1 697149 R 455434 CDS YP_001933635.1 189025863 6333307 complement(698323..698757) 1 NC_010741.1 hypothetical protein 698757 6333307 TPASS_0638 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933635.1 698323 R 455434 CDS YP_001933636.1 189025864 6332858 699177..701141 1 NC_010741.1 methyl-accepting chemotaxis protein 701141 mcp3 6332858 mcp3 Treponema pallidum subsp. pallidum SS14 methyl-accepting chemotaxis protein YP_001933636.1 699177 D 455434 CDS YP_001933637.1 189025865 6333347 701165..703009 1 NC_010741.1 methyl-accepting chemotaxis protein 703009 mcp4 6333347 mcp4 Treponema pallidum subsp. pallidum SS14 methyl-accepting chemotaxis protein YP_001933637.1 701165 D 455434 CDS YP_001933638.1 189025866 6333701 complement(703027..704355) 1 NC_010741.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 704355 hisS 6333701 hisS Treponema pallidum subsp. pallidum SS14 histidyl-tRNA synthetase YP_001933638.1 703027 R 455434 CDS YP_001933639.1 189025867 6333354 704496..706256 1 NC_010741.1 phosphomannomutase 706256 manB 6333354 manB Treponema pallidum subsp. pallidum SS14 phosphomannomutase YP_001933639.1 704496 D 455434 CDS YP_001933640.1 189025868 6333324 706253..706900 1 NC_010741.1 DNA polymerase III, subunit epsilon 706900 dnaQ 6333324 dnaQ Treponema pallidum subsp. pallidum SS14 DNA polymerase III, subunit epsilon YP_001933640.1 706253 D 455434 CDS YP_001933641.1 189025869 6333233 complement(706897..708483) 1 NC_010741.1 class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine; lysyl-tRNA synthetase 708483 lysK 6333233 lysK Treponema pallidum subsp. pallidum SS14 lysyl-tRNA synthetase YP_001933641.1 706897 R 455434 CDS YP_001933642.1 189025870 6333236 complement(708514..708690) 1 NC_010741.1 hypothetical protein 708690 6333236 TPASS_0645 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933642.1 708514 R 455434 CDS YP_001933643.1 189025871 6332969 complement(708749..710071) 1 NC_010741.1 hypothetical protein 710071 6332969 TPASS_0646 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933643.1 708749 R 455434 CDS YP_001933644.1 189025872 6333275 complement(709983..711263) 1 NC_010741.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 711263 serS 6333275 serS Treponema pallidum subsp. pallidum SS14 seryl-tRNA synthetase YP_001933644.1 709983 R 455434 CDS YP_001933645.1 189025873 6333773 complement(711313..713361) 1 NC_010741.1 hypothetical protein 713361 6333773 TPASS_0648 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933645.1 711313 R 455434 CDS YP_001933646.1 189025874 6332910 complement(713306..714103) 1 NC_010741.1 hemolysin 714103 tlyC 6332910 tlyC Treponema pallidum subsp. pallidum SS14 hemolysin YP_001933646.1 713306 R 455434 CDS YP_001933647.1 189025875 6333100 complement(714091..714573) 1 NC_010741.1 metalloprotease 714573 6333100 TPASS_0650 Treponema pallidum subsp. pallidum SS14 metalloprotease YP_001933647.1 714091 R 455434 CDS YP_001933648.1 189025876 6333776 complement(714579..716990) 1 NC_010741.1 hypothetical protein 716990 6333776 TPASS_0651 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933648.1 714579 R 455434 CDS YP_001933649.1 189025877 6333277 717166..718305 1 NC_010741.1 spermidine/putrescine ABC transporter, ATP-binding protein 718305 potA 6333277 potA Treponema pallidum subsp. pallidum SS14 spermidine/putrescine ABC transporter, ATP-binding protein YP_001933649.1 717166 D 455434 CDS YP_001933650.1 189025878 6332924 718302..719201 1 NC_010741.1 spermidine/putrescine ABC transporter, permease protein 719201 potB 6332924 potB Treponema pallidum subsp. pallidum SS14 spermidine/putrescine ABC transporter, permease protein YP_001933650.1 718302 D 455434 CDS YP_001933651.1 189025879 6332790 719194..720012 1 NC_010741.1 spermidine/putrescine ABC transporter, permease protein 720012 potC 6332790 potC Treponema pallidum subsp. pallidum SS14 spermidine/putrescine ABC transporter, permease protein YP_001933651.1 719194 D 455434 CDS YP_001933652.1 189025880 6333306 720048..721094 1 NC_010741.1 spermidine/putrescine ABC transporter, periplasmic binding protein 721094 potD 6333306 potD Treponema pallidum subsp. pallidum SS14 spermidine/putrescine ABC transporter, periplasmic binding protein YP_001933652.1 720048 D 455434 CDS YP_001933653.1 189025881 6333247 721063..721164 1 NC_010741.1 hypothetical protein 721164 6333247 TPASS_0656 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933653.1 721063 D 455434 CDS YP_001933654.1 189025882 6333344 complement(721149..721370) 1 NC_010741.1 carbon storage regulator 721370 csrA 6333344 csrA Treponema pallidum subsp. pallidum SS14 carbon storage regulator YP_001933654.1 721149 R 455434 CDS YP_001933655.1 189025883 6333208 complement(721364..721816) 1 NC_010741.1 binds to flagellin and appears to stabilize flagellin during flagella assembly; flagellar assembly protein FliW 721816 6333208 TPASS_0658 Treponema pallidum subsp. pallidum SS14 flagellar assembly protein FliW YP_001933655.1 721364 R 455434 CDS YP_001933656.1 189025884 6333249 complement(721835..723085) 1 NC_010741.1 With FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgL 723085 flgL 6333249 flgL Treponema pallidum subsp. pallidum SS14 flagellar hook-associated protein FlgL YP_001933656.1 721835 R 455434 CDS YP_001933657.1 189025885 6333113 complement(723119..724996) 1 NC_010741.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 724996 flgK 6333113 flgK Treponema pallidum subsp. pallidum SS14 flagellar hook-associated protein FlgK YP_001933657.1 723119 R 455434 CDS YP_001933658.1 189025886 6333816 complement(725102..725614) 1 NC_010741.1 hypothetical protein 725614 6333816 TPASS_0661 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933658.1 725102 R 455434 CDS YP_001933659.1 189025887 6333841 complement(725737..726735) 1 NC_010741.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 726735 cbbA 6333841 cbbA Treponema pallidum subsp. pallidum SS14 fructose-bisphosphate aldolase YP_001933659.1 725737 R 455434 CDS YP_001933660.1 189025888 6332847 727002..727730 1 NC_010741.1 outer membrane protein 727730 6332847 TPASS_0663 Treponema pallidum subsp. pallidum SS14 outer membrane protein YP_001933660.1 727002 D 455434 CDS YP_001933661.1 189025889 6333339 727727..728452 1 NC_010741.1 flagellar filament outer layer protein 728452 flaA2 6333339 flaA2 Treponema pallidum subsp. pallidum SS14 flagellar filament outer layer protein YP_001933661.1 727727 D 455434 CDS YP_001933662.1 189025890 6333258 complement(728470..729225) 1 NC_010741.1 hypothetical protein 729225 6333258 TPASS_0665 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933662.1 728470 R 455434 CDS YP_001933663.1 189025891 6333321 complement(729222..729515) 1 NC_010741.1 hypothetical protein 729515 6333321 TPASS_0666 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933663.1 729222 R 455434 CDS YP_001933664.1 189025892 6333272 complement(729559..731226) 1 NC_010741.1 uridine kinase 731226 udk 6333272 udk Treponema pallidum subsp. pallidum SS14 uridine kinase YP_001933664.1 729559 R 455434 CDS YP_001933665.1 189025893 6333232 complement(731457..732059) 1 NC_010741.1 hypothetical protein 732059 6333232 TPASS_0668 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933665.1 731457 R 455434 CDS YP_001933666.1 189025894 6332911 complement(732056..735568) 1 NC_010741.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 735568 dnaE 6332911 dnaE Treponema pallidum subsp. pallidum SS14 DNA polymerase III subunit alpha YP_001933666.1 732056 R 455434 CDS YP_001933667.1 189025895 6333185 complement(735722..736912) 1 NC_010741.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 736912 ddl 6333185 ddl Treponema pallidum subsp. pallidum SS14 D-alanyl-alanine synthetase A YP_001933667.1 735722 R 455434 CDS YP_001933668.1 189025896 6333361 complement(736914..737948) 1 NC_010741.1 sn-1,2-diacylglycerol cholinephosphotransferase 737948 6333361 TPASS_0671 Treponema pallidum subsp. pallidum SS14 sn-1,2-diacylglycerol cholinephosphotransferase YP_001933668.1 736914 R 455434 CDS YP_001933669.1 189025897 6333266 complement(737979..739367) 1 NC_010741.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase 739367 glyS 6333266 glyS Treponema pallidum subsp. pallidum SS14 glycyl-tRNA synthetase YP_001933669.1 737979 R 455434 CDS YP_001933670.1 189025898 6333261 complement(739502..741115) 1 NC_010741.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 741115 gltX 6333261 gltX Treponema pallidum subsp. pallidum SS14 glutamyl-tRNA synthetase YP_001933670.1 739502 R 455434 CDS YP_001933671.1 189025899 6332788 741293..741901 1 NC_010741.1 hypothetical protein 741901 6332788 TPASS_0674 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933671.1 741293 D 455434 CDS YP_001933672.1 189025900 6333351 741907..742905 1 NC_010741.1 hypothetical protein 742905 6333351 TPASS_0675 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933672.1 741907 D 455434 CDS YP_001933673.1 189025901 6333667 complement(742917..743195) 1 NC_010741.1 hypothetical protein 743195 6333667 TPASS_0676 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933673.1 742917 R 455434 CDS YP_001933674.1 189025902 6333334 complement(743217..743825) 1 NC_010741.1 hypothetical protein 743825 6333334 TPASS_0677 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933674.1 743217 R 455434 CDS YP_001933675.1 189025903 6332908 744079..745002 1 NC_010741.1 hypothetical protein 745002 6332908 TPASS_0678 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933675.1 744079 D 455434 CDS YP_001933676.1 189025904 6333756 744999..745316 1 NC_010741.1 hypothetical protein 745316 6333756 TPASS_0679 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933676.1 744999 D 455434 CDS YP_001933677.1 189025905 6333316 complement(745357..746415) 1 NC_010741.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 746415 gcp 6333316 gcp Treponema pallidum subsp. pallidum SS14 DNA-binding/iron metalloprotein/AP endonuclease YP_001933677.1 745357 R 455434 CDS YP_001933678.1 189025906 6332919 complement(746466..747599) 1 NC_010741.1 alanine racemase 747599 alr 6332919 alr Treponema pallidum subsp. pallidum SS14 alanine racemase YP_001933678.1 746466 R 455434 CDS YP_001933679.1 189025907 6333345 complement(747628..748230) 1 NC_010741.1 cell division protein 748230 ftsJ 6333345 ftsJ Treponema pallidum subsp. pallidum SS14 cell division protein YP_001933679.1 747628 R 455434 CDS YP_001933680.1 189025908 6333352 748323..749417 1 NC_010741.1 octaprenyl-diphosphate synthase 749417 6333352 TPASS_0683 Treponema pallidum subsp. pallidum SS14 octaprenyl-diphosphate synthase YP_001933680.1 748323 D 455434 CDS YP_001933681.1 189025909 6333265 749710..750921 1 NC_010741.1 methylgalactoside ABC transporter, periplasmic galactose-binding protein 750921 mglB2 6333265 mglB2 Treponema pallidum subsp. pallidum SS14 methylgalactoside ABC transporter, periplasmic galactose-binding protein YP_001933681.1 749710 D 455434 CDS YP_001933682.1 189025910 6333268 751041..752531 1 NC_010741.1 methylgalactoside ABC transporter, ATP binding protein 752531 mglA 6333268 mglA Treponema pallidum subsp. pallidum SS14 methylgalactoside ABC transporter, ATP binding protein YP_001933682.1 751041 D 455434 CDS YP_001933683.1 189025911 6333828 752546..754141 1 NC_010741.1 methylgalactoside ABC transporter, permease protein 754141 mglC 6333828 mglC Treponema pallidum subsp. pallidum SS14 methylgalactoside ABC transporter, permease protein YP_001933683.1 752546 D 455434 CDS YP_001933684.1 189025912 6333798 complement(754269..756329) 1 NC_010741.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 756329 recG 6333798 recG Treponema pallidum subsp. pallidum SS14 ATP-dependent DNA helicase RecG YP_001933684.1 754269 R 455434 CDS YP_001933685.1 189025913 6333221 complement(756385..757398) 1 NC_010741.1 immunity protein 757398 mccF 6333221 mccF Treponema pallidum subsp. pallidum SS14 immunity protein YP_001933685.1 756385 R 455434 CDS YP_001933686.1 189025914 6333222 complement(757399..758781) 1 NC_010741.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 758781 engA 6333222 engA Treponema pallidum subsp. pallidum SS14 GTP-binding protein EngA YP_001933686.1 757399 R 455434 CDS YP_001933687.1 189025915 6333598 complement(758817..759398) 1 NC_010741.1 hypothetical protein 759398 6333598 TPASS_0690 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933687.1 758817 R 455434 CDS YP_001933688.1 189025916 6332917 complement(759391..760149) 1 NC_010741.1 hypothetical protein 760149 6332917 TPASS_0691 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933688.1 759391 R 455434 CDS YP_001933689.1 189025917 6333588 complement(760177..761400) 1 NC_010741.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 761400 recA 6333588 recA Treponema pallidum subsp. pallidum SS14 recombinase A YP_001933689.1 760177 R 455434 CDS YP_001933690.1 189025918 6332915 complement(761661..762983) 1 NC_010741.1 hypothetical protein 762983 6332915 TPASS_0693 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933690.1 761661 R 455434 CDS YP_001933691.1 189025919 6332918 763143..763820 1 NC_010741.1 5,10-methenyltetrahydrofolate synthetase 763820 6332918 TPASS_0694 Treponema pallidum subsp. pallidum SS14 5,10-methenyltetrahydrofolate synthetase YP_001933691.1 763143 D 455434 CDS YP_001933692.1 189025920 6332916 763908..765701 1 NC_010741.1 phosphoribosylglycinamide formyltransferase 765701 6332916 TPASS_0695 Treponema pallidum subsp. pallidum SS14 phosphoribosylglycinamide formyltransferase YP_001933692.1 763908 D 455434 CDS YP_001933693.1 189025921 6333717 complement(765689..766525) 1 NC_010741.1 nicotinamidase 766525 6333717 TPASS_0696 Treponema pallidum subsp. pallidum SS14 nicotinamidase YP_001933693.1 765689 R 455434 CDS YP_001933694.1 189025922 6333705 complement(766587..767195) 1 NC_010741.1 hypothetical protein 767195 6333705 TPASS_0697 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933694.1 766587 R 455434 CDS YP_001933695.1 189025923 6333741 complement(767226..767771) 1 NC_010741.1 hypothetical protein 767771 6333741 TPASS_0698 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933695.1 767226 R 455434 CDS YP_001933696.1 189025924 6333718 complement(767768..767878) 1 NC_010741.1 hypothetical protein 767878 6333718 TPASS_0699 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933696.1 767768 R 455434 CDS YP_001933697.1 189025925 6333744 complement(767884..768276) 1 NC_010741.1 hypothetical protein 768276 6333744 TPASS_0700 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933697.1 767884 R 455434 CDS YP_001933698.1 189025926 6333743 complement(768414..768617) 1 NC_010741.1 DNA-directed RNA polymerase 768617 6333743 TPASS_0701 Treponema pallidum subsp. pallidum SS14 DNA-directed RNA polymerase YP_001933698.1 768414 R 455434 CDS YP_001933699.1 189025927 6333746 complement(768787..769323) 1 NC_010741.1 hypothetical protein 769323 6333746 TPASS_0702 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933699.1 768787 R 455434 CDS YP_001933700.1 189025928 6333224 complement(769338..770018) 1 NC_010741.1 hypothetical protein 770018 6333224 TPASS_0703 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933700.1 769338 R 455434 CDS YP_001933701.1 189025929 6333067 complement(770018..772138) 1 NC_010741.1 single-stranded-DNA-specific exonuclease 772138 recJ 6333067 recJ Treponema pallidum subsp. pallidum SS14 single-stranded-DNA-specific exonuclease YP_001933701.1 770018 R 455434 CDS YP_001933702.1 189025930 6333660 complement(772281..774935) 1 NC_010741.1 penicillin-binding protein 774935 pbp2 6333660 pbp2 Treponema pallidum subsp. pallidum SS14 penicillin-binding protein YP_001933702.1 772281 R 455434 CDS YP_001933703.1 189025931 6333365 complement(775232..776158) 1 NC_010741.1 hypothetical protein 776158 6333365 TPASS_0706 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933703.1 775232 R 455434 CDS YP_001933704.1 189025932 6332904 complement(776220..776699) 1 NC_010741.1 hypothetical protein 776699 6332904 TPASS_0707 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933704.1 776220 R 455434 CDS YP_001933705.1 189025933 6333664 776765..777280 1 NC_010741.1 hypothetical protein 777280 6333664 TPASS_0708 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933705.1 776765 D 455434 CDS YP_001933706.1 189025934 6333226 777336..778124 1 NC_010741.1 involved in the initiation of sporulation and glycogen biosynthesis; RNA polymerase sigma factor WhiG 778124 6333226 TPASS_0709 Treponema pallidum subsp. pallidum SS14 RNA polymerase sigma factor WhiG YP_001933706.1 777336 D 455434 CDS YP_001933707.1 189025935 6333662 778133..780103 1 NC_010741.1 hypothetical protein 780103 6333662 TPASS_0710 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933707.1 778133 D 455434 CDS YP_001933708.1 189025936 6333213 780140..780712 1 NC_010741.1 hypothetical protein 780712 6333213 TPASS_0711 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933708.1 780140 D 455434 CDS YP_001933709.1 189025937 6333665 complement(780727..781641) 1 NC_010741.1 ATP-binding protein 781641 ylxH1 6333665 ylxH1 Treponema pallidum subsp. pallidum SS14 ATP-binding protein YP_001933709.1 780727 R 455434 CDS YP_001933710.1 189025938 6333422 complement(781613..782926) 1 NC_010741.1 flagellar-associated GTP-binding protein 782926 flhF 6333422 flhF Treponema pallidum subsp. pallidum SS14 flagellar-associated GTP-binding protein YP_001933710.1 781613 R 455434 CDS YP_001933711.1 189025939 6333068 complement(782961..785084) 1 NC_010741.1 membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA 785084 flhA 6333068 flhA Treponema pallidum subsp. pallidum SS14 flagellar biosynthesis protein FlhA YP_001933711.1 782961 R 455434 CDS YP_001933712.1 189025940 6333335 complement(785093..786223) 1 NC_010741.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 786223 flhB 6333335 flhB Treponema pallidum subsp. pallidum SS14 flagellar biosynthesis protein FlhB YP_001933712.1 785093 R 455434 CDS YP_001933713.1 189025941 6333860 complement(786220..787017) 1 NC_010741.1 flagellar biosynthetic protein 787017 fliR 6333860 fliR Treponema pallidum subsp. pallidum SS14 flagellar biosynthetic protein YP_001933713.1 786220 R 455434 CDS YP_001933714.1 189025942 6332838 complement(787030..787314) 1 NC_010741.1 flagellar biosynthetic protein 787314 fliQ 6332838 fliQ Treponema pallidum subsp. pallidum SS14 flagellar biosynthetic protein YP_001933714.1 787030 R 455434 CDS YP_001933715.1 189025943 6333858 complement(787333..788148) 1 NC_010741.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 788148 fliP 6333858 fliP Treponema pallidum subsp. pallidum SS14 flagellar biosynthesis protein FliP YP_001933715.1 787333 R 455434 CDS YP_001933716.1 189025944 6333069 complement(788145..788933) 1 NC_010741.1 hypothetical protein 788933 6333069 TPASS_0719 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933716.1 788145 R 455434 CDS YP_001933717.1 189025945 6333874 complement(788869..789915) 1 NC_010741.1 flagellar motor switch protein 789915 fliY 6333874 fliY Treponema pallidum subsp. pallidum SS14 flagellar motor switch protein YP_001933717.1 788869 R 455434 CDS YP_001933718.1 189025946 6332793 complement(789908..790942) 1 NC_010741.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 790942 fliM 6332793 fliM Treponema pallidum subsp. pallidum SS14 flagellar motor switch protein FliM YP_001933718.1 789908 R 455434 CDS YP_001933719.1 189025947 6333212 complement(790964..791512) 1 NC_010741.1 interacts with the cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL 791512 fliL 6333212 fliL Treponema pallidum subsp. pallidum SS14 flagellar basal body-associated protein FliL YP_001933719.1 790964 R 455434 CDS YP_001933720.1 189025948 6333254 complement(791491..791625) 1 NC_010741.1 hypothetical protein 791625 6333254 TPASS_0723 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933720.1 791491 R 455434 CDS YP_001933721.1 189025949 6333856 complement(791622..792338) 1 NC_010741.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 792338 motB 6333856 motB Treponema pallidum subsp. pallidum SS14 flagellar motor protein MotB YP_001933721.1 791622 R 455434 CDS YP_001933722.1 189025950 6333476 complement(792344..793123) 1 NC_010741.1 flagellar motor rotation protein 793123 motA 6333476 motA Treponema pallidum subsp. pallidum SS14 flagellar motor rotation protein YP_001933722.1 792344 R 455434 CDS YP_001933723.1 189025951 6333661 complement(793139..793336) 1 NC_010741.1 flagellar protein 793336 flbD 6333661 flbD Treponema pallidum subsp. pallidum SS14 flagellar protein YP_001933723.1 793139 R 455434 CDS YP_001933724.1 189025952 6333789 complement(793394..794785) 1 NC_010741.1 the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 794785 flgE 6333789 flgE Treponema pallidum subsp. pallidum SS14 flagellar hook protein FlgE YP_001933724.1 793394 R 455434 CDS YP_001933725.1 189025953 6333209 complement(794856..795317) 1 NC_010741.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; flagellar basal body rod modification protein 795317 flgD 6333209 flgD Treponema pallidum subsp. pallidum SS14 flagellar basal body rod modification protein YP_001933725.1 794856 R 455434 CDS YP_001933726.1 189025954 6332805 complement(795393..797036) 1 NC_010741.1 treponemal aqueous protein 797036 tap1 6332805 tap1 Treponema pallidum subsp. pallidum SS14 treponemal aqueous protein YP_001933726.1 795393 R 455434 CDS YP_001933727.1 189025955 6333796 797005..798102 1 NC_010741.1 hypothetical protein 798102 6333796 TPASS_0730 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933727.1 797005 D 455434 CDS YP_001933728.1 189025956 6333510 798122..798832 1 NC_010741.1 hypothetical protein 798832 6333510 TPASS_0731 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933728.1 798122 D 455434 CDS YP_001933729.1 189025957 6333528 complement(798797..799744) 1 NC_010741.1 methylenetetrahydrofolate dehydrogenase 799744 folD 6333528 folD Treponema pallidum subsp. pallidum SS14 methylenetetrahydrofolate dehydrogenase YP_001933729.1 798797 R 455434 CDS YP_001933730.1 189025958 6333500 799840..800499 1 NC_010741.1 hypothetical protein 800499 6333500 TPASS_0733 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933730.1 799840 D 455434 CDS YP_001933731.1 189025959 6333005 complement(800532..801233) 1 NC_010741.1 purine nucleoside phosphorylase 801233 deoD 6333005 deoD Treponema pallidum subsp. pallidum SS14 purine nucleoside phosphorylase YP_001933731.1 800532 R 455434 CDS YP_001933732.1 189025960 6333492 complement(801315..802871) 1 NC_010741.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; oxidoreductase 802871 gltA 6333492 gltA Treponema pallidum subsp. pallidum SS14 oxidoreductase YP_001933732.1 801315 R 455434 CDS YP_001933733.1 189025961 6333519 complement(802874..803716) 1 NC_010741.1 ferredoxin-NADP(+) reductase subunit alpha 803716 hydG 6333519 hydG Treponema pallidum subsp. pallidum SS14 ferredoxin-NADP(+) reductase subunit alpha YP_001933733.1 802874 R 455434 CDS YP_001933734.1 189025962 6333482 803950..805260 1 NC_010741.1 sugar ABC transporter, periplasmic binding protein 805260 msmE 6333482 msmE Treponema pallidum subsp. pallidum SS14 sugar ABC transporter, periplasmic binding protein YP_001933734.1 803950 D 455434 CDS YP_001933735.1 189025963 6333488 complement(805306..805641) 1 NC_010741.1 hypothetical protein 805641 6333488 TPASS_0738 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933735.1 805306 R 455434 CDS YP_001933736.1 189025964 6333471 complement(805638..806834) 1 NC_010741.1 hypothetical protein 806834 6333471 TPASS_0739 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933736.1 805638 R 455434 CDS YP_001933737.1 189025965 6333287 complement(806908..807474) 1 NC_010741.1 hypothetical protein 807474 6333287 TPASS_0740 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933737.1 806908 R 455434 CDS YP_001933738.1 189025966 6332971 complement(807602..808216) 1 NC_010741.1 hypothetical protein 808216 6332971 TPASS_0741 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933738.1 807602 R 455434 CDS YP_001933739.1 189025967 6333469 complement(808213..809343) 1 NC_010741.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 809343 obgE 6333469 obgE Treponema pallidum subsp. pallidum SS14 GTPase ObgE YP_001933739.1 808213 R 455434 CDS YP_001933740.1 189025968 6333449 complement(809461..809724) 1 NC_010741.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 809724 rpmA 6333449 rpmA Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L27 YP_001933740.1 809461 R 455434 CDS YP_001933741.1 189025969 6333462 complement(809755..810081) 1 NC_010741.1 hypothetical protein 810081 6333462 TPASS_0744 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933741.1 809755 R 455434 CDS YP_001933742.1 189025970 6333869 complement(810094..810411) 1 NC_010741.1 50S ribosomal protein L21 810411 rplU 6333869 rplU Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L21 YP_001933742.1 810094 R 455434 CDS YP_001933743.1 189025971 6333875 complement(810518..813223) 1 NC_010741.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 813223 6333875 TPASS_0746 Treponema pallidum subsp. pallidum SS14 pyruvate phosphate dikinase YP_001933743.1 810518 R 455434 CDS YP_001933744.1 189025972 6333825 complement(813233..814267) 1 NC_010741.1 hypothetical protein 814267 6333825 TPASS_0747 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933744.1 813233 R 455434 CDS YP_001933745.1 189025973 6333827 complement(814356..816392) 1 NC_010741.1 cytoplasmic filament protein A 816392 cfpA 6333827 cfpA Treponema pallidum subsp. pallidum SS14 cytoplasmic filament protein A YP_001933745.1 814356 R 455434 CDS YP_001933746.1 189025974 6333826 complement(816370..816591) 1 NC_010741.1 hypothetical protein 816591 6333826 TPASS_0749 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933746.1 816370 R 455434 CDS YP_001933747.1 189025975 6333824 816561..817232 1 NC_010741.1 hypothetical protein 817232 6333824 TPASS_0750 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933747.1 816561 D 455434 CDS YP_001933748.1 189025976 6332913 817269..817982 1 NC_010741.1 laminin-binding protein 817982 6332913 TPASS_0751 Treponema pallidum subsp. pallidum SS14 laminin-binding protein YP_001933748.1 817269 D 455434 CDS YP_001933749.1 189025977 6333218 complement(818120..819262) 1 NC_010741.1 hypothetical protein 819262 6333218 TPASS_0752 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933749.1 818120 R 455434 CDS YP_001933750.1 189025978 6333840 complement(819343..819627) 1 NC_010741.1 hypothetical protein 819627 6333840 TPASS_0753 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933750.1 819343 R 455434 CDS YP_001933751.1 189025979 6333836 complement(819624..820994) 1 NC_010741.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 820994 6333836 TPASS_0754 Treponema pallidum subsp. pallidum SS14 (dimethylallyl)adenosine tRNA methylthiotransferase YP_001933751.1 819624 R 455434 CDS YP_001933752.1 189025980 6333294 complement(821036..821578) 1 NC_010741.1 PTS system, nitrogen regulatory IIA component 821578 ptsN2 6333294 ptsN2 Treponema pallidum subsp. pallidum SS14 PTS system, nitrogen regulatory IIA component YP_001933752.1 821036 R 455434 CDS YP_001933753.1 189025981 6333246 complement(821778..822737) 1 NC_010741.1 methionyl-tRNA formyltransferase 822737 fmt 6333246 fmt Treponema pallidum subsp. pallidum SS14 methionyl-tRNA formyltransferase YP_001933753.1 821778 R 455434 CDS YP_001933754.1 189025982 6333575 complement(822741..823229) 1 NC_010741.1 polypeptide deformylase 823229 def 6333575 def Treponema pallidum subsp. pallidum SS14 polypeptide deformylase YP_001933754.1 822741 R 455434 CDS YP_001933755.1 189025983 6333574 complement(823270..823479) 1 NC_010741.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 823479 rpsU 6333574 rpsU Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S21 YP_001933755.1 823270 R 455434 CDS YP_001933756.1 189025984 6333293 823598..823717 1 NC_010741.1 hypothetical protein 823717 6333293 TPASS_0759 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933756.1 823598 D 455434 CDS YP_001933757.1 189025985 6333587 823674..825632 1 NC_010741.1 penicillin-binding protein 825632 pbp3 6333587 pbp3 Treponema pallidum subsp. pallidum SS14 penicillin-binding protein YP_001933757.1 823674 D 455434 CDS YP_001933758.1 189025986 6333568 825613..826491 1 NC_010741.1 hypothetical protein 826491 6333568 TPASS_0761 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933758.1 825613 D 455434 CDS YP_001933759.1 189025987 6333245 826520..827701 1 NC_010741.1 hypothetical protein 827701 6333245 TPASS_0762 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933759.1 826520 D 455434 CDS YP_001933760.1 189025988 6333700 complement(827763..828704) 1 NC_010741.1 hypothetical protein 828704 6333700 TPASS_0763 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933760.1 827763 R 455434 CDS YP_001933761.1 189025989 6333596 828663..829838 1 NC_010741.1 hypothetical protein 829838 6333596 TPASS_0764 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933761.1 828663 D 455434 CDS YP_001933762.1 189025990 6333244 complement(829820..831649) 1 NC_010741.1 cell division protein 831649 ftsH 6333244 ftsH Treponema pallidum subsp. pallidum SS14 cell division protein YP_001933762.1 829820 R 455434 CDS YP_001933763.1 189025991 6333291 832052..832933 1 NC_010741.1 hypothetical protein 832933 6333291 TPASS_0766 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933763.1 832052 D 455434 CDS YP_001933764.1 189025992 6333290 833144..835231 1 NC_010741.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 835231 fusA2 6333290 fusA2 Treponema pallidum subsp. pallidum SS14 elongation factor G YP_001933764.1 833144 D 455434 CDS YP_001933765.1 189025993 6333292 835370..836407 1 NC_010741.1 membrane protein 836407 tmpA 6333292 tmpA Treponema pallidum subsp. pallidum SS14 membrane protein YP_001933765.1 835370 D 455434 CDS YP_001933766.1 189025994 6333871 836404..837381 1 NC_010741.1 outer membrane protein 837381 tmpB 6333871 tmpB Treponema pallidum subsp. pallidum SS14 outer membrane protein YP_001933766.1 836404 D 455434 CDS YP_001933767.1 189025995 6333070 837426..839375 1 NC_010741.1 ATP-dependent RNA helicase 839375 6333070 TPASS_0770 Treponema pallidum subsp. pallidum SS14 ATP-dependent RNA helicase YP_001933767.1 837426 D 455434 CDS YP_001933768.1 189025996 6333854 complement(839396..841177) 1 NC_010741.1 hypothetical protein 841177 6333854 TPASS_0771 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933768.1 839396 R 455434 CDS YP_001933769.1 189025997 6333851 841181..842005 1 NC_010741.1 hypothetical protein 842005 6333851 TPASS_0772 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933769.1 841181 D 455434 CDS YP_001933770.1 189025998 6333857 complement(842045..843241) 1 NC_010741.1 periplasmic serine protease DO 843241 htrA1 6333857 htrA1 Treponema pallidum subsp. pallidum SS14 periplasmic serine protease DO YP_001933770.1 842045 R 455434 CDS YP_001933771.1 189025999 6333832 843586..844260 1 NC_010741.1 Mg2+ transport protein 844260 mgtC 6333832 mgtC Treponema pallidum subsp. pallidum SS14 Mg2+ transport protein YP_001933771.1 843586 D 455434 CDS YP_001933772.1 189026000 6333835 844340..844975 1 NC_010741.1 endonuclease III 844975 nth 6333835 nth Treponema pallidum subsp. pallidum SS14 endonuclease III YP_001933772.1 844340 D 455434 CDS YP_001933773.1 189026001 6333834 complement(845052..845828) 1 NC_010741.1 hypothetical protein 845828 6333834 TPASS_0776 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933773.1 845052 R 455434 CDS YP_001933774.1 189026002 6333848 complement(845881..846105) 1 NC_010741.1 hypothetical protein 846105 6333848 TPASS_0777 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933774.1 845881 R 455434 CDS YP_001933775.1 189026003 6333838 complement(846174..847085) 1 NC_010741.1 protein MazG 847085 mazG 6333838 mazG Treponema pallidum subsp. pallidum SS14 protein MazG YP_001933775.1 846174 R 455434 CDS YP_001933776.1 189026004 6333839 complement(847082..847726) 1 NC_010741.1 protein DedA 847726 dedA 6333839 dedA Treponema pallidum subsp. pallidum SS14 protein DedA YP_001933776.1 847082 R 455434 CDS YP_001933777.1 189026005 6333852 complement(847773..849812) 1 NC_010741.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 849812 nadE 6333852 nadE Treponema pallidum subsp. pallidum SS14 NAD synthetase YP_001933777.1 847773 R 455434 CDS YP_001933778.1 189026006 6332814 complement(849849..850310) 1 NC_010741.1 hypothetical protein 850310 6332814 TPASS_0781 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933778.1 849849 R 455434 CDS YP_001933779.1 189026007 6333666 complement(850356..850799) 1 NC_010741.1 hypothetical protein 850799 6333666 TPASS_0782 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933779.1 850356 R 455434 CDS YP_001933780.1 189026008 6332818 complement(850828..851961) 1 NC_010741.1 hypothetical protein 851961 6332818 TPASS_0783 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933780.1 850828 R 455434 CDS YP_001933781.1 189026009 6333829 852127..852726 1 NC_010741.1 hypothetical protein 852726 6333829 TPASS_0784 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933781.1 852127 D 455434 CDS YP_001933782.1 189026010 6332804 852723..853409 1 NC_010741.1 hypothetical protein 853409 6332804 TPASS_0785 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933782.1 852723 D 455434 CDS YP_001933783.1 189026011 6333853 853541..854254 1 NC_010741.1 ABC transporter, ATP-binding protein 854254 6333853 TPASS_0786 Treponema pallidum subsp. pallidum SS14 ABC transporter, ATP-binding protein YP_001933783.1 853541 D 455434 CDS YP_001933784.1 189026012 6332883 complement(854301..854720) 1 NC_010741.1 hypothetical protein 854720 6332883 TPASS_0787 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933784.1 854301 R 455434 CDS YP_001933785.1 189026013 6332892 854802..855692 1 NC_010741.1 hypothetical protein 855692 6332892 TPASS_0788 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933785.1 854802 D 455434 CDS YP_001933786.1 189026014 6333842 complement(855705..856481) 1 NC_010741.1 hypothetical protein 856481 6333842 TPASS_0789 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933786.1 855705 R 455434 CDS YP_001933787.1 189026015 6332896 complement(856500..859166) 1 NC_010741.1 antibiotic transport protein 859166 6332896 TPASS_0790 Treponema pallidum subsp. pallidum SS14 antibiotic transport protein YP_001933787.1 856500 R 455434 CDS YP_001933788.1 189026016 6333844 complement(859309..859554) 1 NC_010741.1 hypothetical protein 859554 6333844 TPASS_0791 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933788.1 859309 R 455434 CDS YP_001933789.1 189026017 6333847 859540..860400 1 NC_010741.1 flagellar filament 33 kDa core protein 860400 flaB2 6333847 flaB2 Treponema pallidum subsp. pallidum SS14 flagellar filament 33 kDa core protein YP_001933789.1 859540 D 455434 CDS YP_001933790.1 189026018 6333843 860479..862098 1 NC_010741.1 hypothetical protein 862098 6333843 TPASS_0793 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933790.1 860479 D 455434 CDS YP_001933791.1 189026019 6333330 complement(862135..863325) 1 NC_010741.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 863325 metK 6333330 metK Treponema pallidum subsp. pallidum SS14 S-adenosylmethionine synthetase YP_001933791.1 862135 R 455434 CDS YP_001933792.1 189026020 6333329 863379..863537 1 NC_010741.1 hypothetical protein 863537 6333329 TPASS_0795 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933792.1 863379 D 455434 CDS YP_001933793.1 189026021 6333271 complement(863526..864614) 1 NC_010741.1 hypothetical protein 864614 6333271 TPASS_0796 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933793.1 863526 R 455434 CDS YP_001933794.1 189026022 6333328 complement(864674..865465) 1 NC_010741.1 1-pyrroline-5-carboxylate reductase 865465 proC 6333328 proC Treponema pallidum subsp. pallidum SS14 1-pyrroline-5-carboxylate reductase YP_001933794.1 864674 R 455434 CDS YP_001933795.1 189026023 6333326 complement(865516..867951) 1 NC_010741.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 867951 metG 6333326 metG Treponema pallidum subsp. pallidum SS14 methionyl-tRNA synthetase YP_001933795.1 865516 R 455434 CDS YP_001933796.1 189026024 6332936 867984..868136 1 NC_010741.1 hypothetical protein 868136 6332936 TPASS_0799 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933796.1 867984 D 455434 CDS YP_001933797.1 189026025 6333383 868279..869751 1 NC_010741.1 serine-type D-Ala-D-Ala carboxypeptidase 869751 dacC 6333383 dacC Treponema pallidum subsp. pallidum SS14 serine-type D-Ala-D-Ala carboxypeptidase YP_001933797.1 868279 D 455434 CDS YP_001933798.1 189026026 6332935 complement(869812..872241) 1 NC_010741.1 ATP-dependent Clp protease, subunit A 872241 clpA 6332935 clpA Treponema pallidum subsp. pallidum SS14 ATP-dependent Clp protease, subunit A YP_001933798.1 869812 R 455434 CDS YP_001933799.1 189026027 6333382 872287..872616 1 NC_010741.1 hypothetical protein 872616 6333382 TPASS_0802 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933799.1 872287 D 455434 CDS YP_001933800.1 189026028 6333380 872630..873838 1 NC_010741.1 hypothetical protein 873838 6333380 TPASS_0803 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933800.1 872630 D 455434 CDS YP_001933801.1 189026029 6332934 873916..875079 1 NC_010741.1 sugar ABC transporter, ATP-binding protein 875079 ugpC 6332934 ugpC Treponema pallidum subsp. pallidum SS14 sugar ABC transporter, ATP-binding protein YP_001933801.1 873916 D 455434 CDS YP_001933802.1 189026030 6333378 complement(874930..877209) 1 NC_010741.1 exoribonuclease II 877209 rnb 6333378 rnb Treponema pallidum subsp. pallidum SS14 exoribonuclease II YP_001933802.1 874930 R 455434 CDS YP_001933803.1 189026031 6332933 complement(877206..878702) 1 NC_010741.1 protein FemA 878702 6332933 TPASS_0806 Treponema pallidum subsp. pallidum SS14 protein FemA YP_001933803.1 877206 R 455434 CDS YP_001933804.1 189026032 6333373 878831..879019 1 NC_010741.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 879019 rpmF 6333373 rpmF Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L32 YP_001933804.1 878831 D 455434 CDS YP_001933805.1 189026033 6333374 879080..879316 1 NC_010741.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 879316 acpP 6333374 acpP Treponema pallidum subsp. pallidum SS14 acyl carrier protein YP_001933805.1 879080 D 455434 CDS YP_001933806.1 189026034 6332928 879313..880077 1 NC_010741.1 ribonuclease III 880077 rnc 6332928 rnc Treponema pallidum subsp. pallidum SS14 ribonuclease III YP_001933806.1 879313 D 455434 CDS YP_001933807.1 189026035 6332929 880108..881019 1 NC_010741.1 DNA adenine methyltransferase 881019 dam 6332929 dam Treponema pallidum subsp. pallidum SS14 DNA adenine methyltransferase YP_001933807.1 880108 D 455434 CDS YP_001933808.1 189026036 6333372 complement(881090..881215) 1 NC_010741.1 hypothetical protein 881215 6333372 TPASS_0811 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933808.1 881090 R 455434 CDS YP_001933809.1 189026037 6333384 complement(882626..883912) 1 NC_010741.1 hypothetical protein 883912 6333384 TPASS_0813 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933809.1 882626 R 455434 CDS YP_001933810.1 189026038 6333385 884135..885058 1 NC_010741.1 thioredoxin reductase 885058 trxB 6333385 trxB Treponema pallidum subsp. pallidum SS14 thioredoxin reductase YP_001933810.1 884135 D 455434 CDS YP_001933811.1 189026039 6333371 885180..886163 1 NC_010741.1 hypothetical protein 886163 6333371 TPASS_0815 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933811.1 885180 D 455434 CDS YP_001933812.1 189026040 6333370 complement(886235..886900) 1 NC_010741.1 hypothetical protein 886900 6333370 TPASS_0816 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933812.1 886235 R 455434 CDS YP_001933813.1 189026041 6333388 complement(887038..888336) 1 NC_010741.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 888336 eno 6333388 eno Treponema pallidum subsp. pallidum SS14 phosphopyruvate hydratase YP_001933813.1 887038 R 455434 CDS YP_001933814.1 189026042 6332939 complement(888333..888485) 1 NC_010741.1 hypothetical protein 888485 6332939 TPASS_0818 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933814.1 888333 R 455434 CDS YP_001933815.1 189026043 6333391 complement(888512..889444) 1 NC_010741.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 889444 6333391 TPASS_0819 Treponema pallidum subsp. pallidum SS14 ribonuclease Z YP_001933815.1 888512 R 455434 CDS YP_001933816.1 189026044 6332940 complement(889472..890242) 1 NC_010741.1 hypothetical protein 890242 6332940 TPASS_0820 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933816.1 889472 R 455434 CDS YP_001933817.1 189026045 6333394 complement(890338..891144) 1 NC_010741.1 lipoprotein Tpn32 891144 tpn32 6333394 tpn32 Treponema pallidum subsp. pallidum SS14 lipoprotein Tpn32 YP_001933817.1 890338 R 455434 CDS YP_001933818.1 189026046 6332941 complement(891225..892130) 1 NC_010741.1 hypothetical protein 892130 6332941 TPASS_0822 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933818.1 891225 R 455434 CDS YP_001933819.1 189026047 6333395 complement(892218..892604) 1 NC_010741.1 desulfoferrodoxin 892604 rbo 6333395 rbo Treponema pallidum subsp. pallidum SS14 desulfoferrodoxin YP_001933819.1 892218 R 455434 CDS YP_001933820.1 189026048 6333397 893001..894893 1 NC_010741.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 894893 dxs 6333397 dxs Treponema pallidum subsp. pallidum SS14 1-deoxy-D-xylulose-5-phosphate synthase YP_001933820.1 893001 D 455434 CDS YP_001933821.1 189026049 6332944 894890..895075 1 NC_010741.1 hypothetical protein 895075 6332944 TPASS_0825 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933821.1 894890 D 455434 CDS YP_001933822.1 189026050 6332943 895062..895883 1 NC_010741.1 hypothetical protein 895883 6332943 TPASS_0826 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933822.1 895062 D 455434 CDS YP_001933823.1 189026051 6333402 895546..896823 1 NC_010741.1 hypothetical protein 896823 6333402 TPASS_0827 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933823.1 895546 D 455434 CDS YP_001933824.1 189026052 6333401 896820..897197 1 NC_010741.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 897197 acpS 6333401 acpS Treponema pallidum subsp. pallidum SS14 4'-phosphopantetheinyl transferase YP_001933824.1 896820 D 455434 CDS YP_001933825.1 189026053 6332946 897194..898078 1 NC_010741.1 hypothetical protein 898078 6332946 TPASS_0829 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933825.1 897194 D 455434 CDS YP_001933826.1 189026054 6333404 898075..898917 1 NC_010741.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 898917 truA 6333404 truA Treponema pallidum subsp. pallidum SS14 tRNA pseudouridine synthase A YP_001933826.1 898075 D 455434 CDS YP_001933827.1 189026055 6332947 complement(898927..900696) 1 NC_010741.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 900696 argS 6332947 argS Treponema pallidum subsp. pallidum SS14 arginyl-tRNA synthetase YP_001933827.1 898927 R 455434 CDS YP_001933828.1 189026056 6333406 complement(900719..901534) 1 NC_010741.1 hypothetical protein 901534 6333406 TPASS_0832 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933828.1 900719 R 455434 CDS YP_001933829.1 189026057 6333408 901601..902323 1 NC_010741.1 hypothetical protein 902323 6333408 TPASS_0833 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933829.1 901601 D 455434 CDS YP_001933830.1 189026058 6333407 complement(902380..903630) 1 NC_010741.1 tyrosyl-tRNA synthetase 903630 tyrS 6333407 tyrS Treponema pallidum subsp. pallidum SS14 tyrosyl-tRNA synthetase YP_001933830.1 902380 R 455434 CDS YP_001933831.1 189026059 6333409 complement(903717..906521) 1 NC_010741.1 ankyrin 906521 6333409 TPASS_0835 Treponema pallidum subsp. pallidum SS14 ankyrin YP_001933831.1 903717 R 455434 CDS YP_001933832.1 189026060 6333410 complement(906662..907486) 1 NC_010741.1 hypothetical protein 907486 6333410 TPASS_0836 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933832.1 906662 R 455434 CDS YP_001933833.1 189026061 6333411 907634..909412 1 NC_010741.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 909412 thrS 6333411 thrS Treponema pallidum subsp. pallidum SS14 threonyl-tRNA synthetase YP_001933833.1 907634 D 455434 CDS YP_001933834.1 189026062 6332949 complement(909461..911125) 1 NC_010741.1 ABC transporter, ATP-binding protein 911125 6332949 TPASS_0838 Treponema pallidum subsp. pallidum SS14 ABC transporter, ATP-binding protein YP_001933834.1 909461 R 455434 CDS YP_001933835.1 189026063 6333413 complement(911200..912207) 1 NC_010741.1 hypothetical protein 912207 6333413 TPASS_0839 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933835.1 911200 R 455434 CDS YP_001933836.1 189026064 6333412 912312..914561 1 NC_010741.1 hypothetical protein 914561 6333412 TPASS_0840 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933836.1 912312 D 455434 CDS YP_001933837.1 189026065 6332950 complement(914623..916080) 1 NC_010741.1 periplasmic serine protease DO 916080 htrA2 6332950 htrA2 Treponema pallidum subsp. pallidum SS14 periplasmic serine protease DO YP_001933837.1 914623 R 455434 CDS YP_001933838.1 189026066 6333414 complement(916392..917159) 1 NC_010741.1 methionine aminopeptidase 917159 map 6333414 map Treponema pallidum subsp. pallidum SS14 methionine aminopeptidase YP_001933838.1 916392 R 455434 CDS YP_001933839.1 189026067 6332953 complement(917283..918107) 1 NC_010741.1 heat shock protein 918107 6332953 TPASS_0843 Treponema pallidum subsp. pallidum SS14 heat shock protein YP_001933839.1 917283 R 455434 CDS YP_001933840.1 189026068 6333418 918200..919252 1 NC_010741.1 glyceraldehyde 3-phosphate dehydrogenase 919252 gap 6333418 gap Treponema pallidum subsp. pallidum SS14 glyceraldehyde 3-phosphate dehydrogenase YP_001933840.1 918200 D 455434 CDS YP_001933841.1 189026069 6333420 complement(919307..919897) 1 NC_010741.1 hypothetical protein 919897 6333420 TPASS_0845 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933841.1 919307 R 455434 CDS YP_001933842.1 189026070 6333419 complement(919878..920204) 1 NC_010741.1 hypothetical protein 920204 6333419 TPASS_0846 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933842.1 919878 R 455434 CDS YP_001933843.1 189026071 6333421 complement(920204..920539) 1 NC_010741.1 hypothetical protein 920539 6333421 TPASS_0847 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933843.1 920204 R 455434 CDS YP_001933844.1 189026072 6332955 complement(920533..920901) 1 NC_010741.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 920901 rplT 6332955 rplT Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L20 YP_001933844.1 920533 R 455434 CDS YP_001933845.1 189026073 6333424 complement(920934..921134) 1 NC_010741.1 50S ribosomal protein L35 921134 rpmI 6333424 rpmI Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L35 YP_001933845.1 920934 R 455434 CDS YP_001933846.1 189026074 6333423 complement(921187..921726) 1 NC_010741.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 921726 infC 6333423 infC Treponema pallidum subsp. pallidum SS14 translation initiation factor IF-3 YP_001933846.1 921187 R 455434 CDS YP_001933847.1 189026075 6333426 921889..924063 1 NC_010741.1 hypothetical protein 924063 6333426 TPASS_0851 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933847.1 921889 D 455434 CDS YP_001933848.1 189026076 6332956 complement(924092..925090) 1 NC_010741.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 925090 lgt 6332956 lgt Treponema pallidum subsp. pallidum SS14 prolipoprotein diacylglyceryl transferase YP_001933848.1 924092 R 455434 CDS YP_001933849.1 189026077 6332957 complement(925241..926377) 1 NC_010741.1 ATP-binding protein 926377 ylxH2 6332957 ylxH2 Treponema pallidum subsp. pallidum SS14 ATP-binding protein YP_001933849.1 925241 R 455434 CDS YP_001933850.1 189026078 6333428 complement(926432..931033) 1 NC_010741.1 hypothetical protein 931033 6333428 TPASS_0854 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933850.1 926432 R 455434 CDS YP_001933851.1 189026079 6333430 complement(931030..934413) 1 NC_010741.1 hypothetical protein 934413 6333430 TPASS_0855 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933851.1 931030 R 455434 CDS YP_001933852.1 189026080 6333429 934569..935546 1 NC_010741.1 hypothetical protein 935546 6333429 TPASS_0856 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933852.1 934569 D 455434 CDS YP_001933853.1 189026081 6333431 complement(935549..935869) 1 NC_010741.1 hypothetical protein 935869 6333431 TPASS_0857 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933853.1 935549 R 455434 CDS YP_001933854.1 189026082 6332959 935854..937080 1 NC_010741.1 hypothetical protein 937080 6332959 TPASS_0858 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933854.1 935854 D 455434 CDS YP_001933855.1 189026083 6332960 937162..937860 1 NC_010741.1 hypothetical protein 937860 6332960 TPASS_0859 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933855.1 937162 D 455434 CDS YP_001933856.1 189026084 6332961 937925..938647 1 NC_010741.1 hypothetical protein 938647 6332961 TPASS_0860 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933856.1 937925 D 455434 CDS YP_001933857.1 189026085 6333434 complement(938722..940629) 1 NC_010741.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 940629 glmS 6333434 glmS Treponema pallidum subsp. pallidum SS14 glucosamine--fructose-6-phosphate aminotransferase YP_001933857.1 938722 R 455434 CDS YP_001933858.1 189026086 6333435 complement(940866..941660) 1 NC_010741.1 peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa 941660 fklB 6333435 fklB Treponema pallidum subsp. pallidum SS14 peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa YP_001933858.1 940866 R 455434 CDS YP_001933859.1 189026087 6333438 941795..943078 1 NC_010741.1 nitrogen fixation protein 943078 nifS2 6333438 nifS2 Treponema pallidum subsp. pallidum SS14 nitrogen fixation protein YP_001933859.1 941795 D 455434 CDS YP_001933860.1 189026088 6332962 complement(943137..944777) 1 NC_010741.1 hypothetical protein 944777 6332962 TPASS_0864 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933860.1 943137 R 455434 CDS YP_001933861.1 189026089 6333416 complement(944811..946253) 1 NC_010741.1 hypothetical protein 946253 6333416 TPASS_0865 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933861.1 944811 R 455434 CDS YP_001933862.1 189026090 6333369 complement(948246..948431) 1 NC_010741.1 hypothetical protein 948431 6333369 TPASS_0867 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933862.1 948246 R 455434 CDS YP_001933863.1 189026091 6332925 948600..948956 1 NC_010741.1 flagellar filament 34.5 kDa core protein 948956 flaB1 6332925 flaB1 Treponema pallidum subsp. pallidum SS14 flagellar filament 34.5 kDa core protein YP_001933863.1 948600 D 455434 CDS YP_001933864.1 189026092 6332926 949468..949704 1 NC_010741.1 hypothetical protein 949704 6332926 TPASS_0869 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933864.1 949468 D 455434 CDS YP_001933865.1 189026093 6333368 949732..950589 1 NC_010741.1 flagellar filament 31 kDa core protein 950589 flaB3 6333368 flaB3 Treponema pallidum subsp. pallidum SS14 flagellar filament 31 kDa core protein YP_001933865.1 949732 D 455434 CDS YP_001933866.1 189026094 6333367 complement(950650..950811) 1 NC_010741.1 hypothetical protein 950811 6333367 TPASS_0871 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933866.1 950650 R 455434 CDS YP_001933867.1 189026095 6333656 950887..953055 1 NC_010741.1 involved in flagellin assembly; flagellar hook-associated protein FliD 953055 fliD 6333656 fliD Treponema pallidum subsp. pallidum SS14 flagellar hook-associated protein FliD YP_001933867.1 950887 D 455434 CDS YP_001933868.1 189026096 6333065 953067..953669 1 NC_010741.1 hypothetical protein 953669 6333065 TPASS_0873 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933868.1 953067 D 455434 CDS YP_001933869.1 189026097 6333659 953666..953941 1 NC_010741.1 hypothetical protein 953941 6333659 TPASS_0874 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933869.1 953666 D 455434 CDS YP_001933870.1 189026098 6333650 953981..954388 1 NC_010741.1 hypothetical protein 954388 6333650 TPASS_0875 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933870.1 953981 D 455434 CDS YP_001933871.1 189026099 6333657 954435..955100 1 NC_010741.1 hypothetical protein 955100 6333657 TPASS_0876 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933871.1 954435 D 455434 CDS YP_001933872.1 189026100 6333357 955105..956202 1 NC_010741.1 hypothetical protein 956202 6333357 TPASS_0877 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933872.1 955105 D 455434 CDS YP_001933873.1 189026101 6333206 complement(956215..957165) 1 NC_010741.1 hypothetical protein 957165 6333206 TPASS_0878 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933873.1 956215 R 455434 CDS YP_001933874.1 189026102 6333063 complement(957171..958652) 1 NC_010741.1 hypothetical protein 958652 6333063 TPASS_0879 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933874.1 957171 R 455434 CDS YP_001933875.1 189026103 6333064 complement(958649..959374) 1 NC_010741.1 membrane spanning protein 959374 6333064 TPASS_0880 Treponema pallidum subsp. pallidum SS14 membrane spanning protein YP_001933875.1 958649 R 455434 CDS YP_001933876.1 189026104 6333653 complement(959364..960170) 1 NC_010741.1 ABC transporter, ATP-binding protein 960170 natA 6333653 natA Treponema pallidum subsp. pallidum SS14 ABC transporter, ATP-binding protein YP_001933876.1 959364 R 455434 CDS YP_001933877.1 189026105 6332835 complement(960249..961751) 1 NC_010741.1 hypothetical protein 961751 6332835 TPASS_0882 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933877.1 960249 R 455434 CDS YP_001933878.1 189026106 6333652 complement(961717..962814) 1 NC_010741.1 hypothetical protein 962814 6333652 TPASS_0883 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933878.1 961717 R 455434 CDS YP_001933879.1 189026107 6333655 complement(962832..963920) 1 NC_010741.1 hypothetical protein 963920 6333655 TPASS_0884 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933879.1 962832 R 455434 CDS YP_001933880.1 189026108 6333651 complement(963950..964390) 1 NC_010741.1 deoxyuridine 5'-triphosphate nucleotidohydrolase 964390 dut 6333651 dut Treponema pallidum subsp. pallidum SS14 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_001933880.1 963950 R 455434 CDS YP_001933881.1 189026109 6332836 complement(964387..966495) 1 NC_010741.1 polynucleotide phosphorylase/polyadenylase 966495 pnp 6332836 pnp Treponema pallidum subsp. pallidum SS14 polynucleotide phosphorylase/polyadenylase YP_001933881.1 964387 R 455434 CDS YP_001933882.1 189026110 6333649 complement(966643..966912) 1 NC_010741.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 966912 rpsO 6333649 rpsO Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S15 YP_001933882.1 966643 R 455434 CDS YP_001933883.1 189026111 6332834 complement(966928..967755) 1 NC_010741.1 riboflavin kinase/FMN adenylyltransferase 967755 ribF 6332834 ribF Treponema pallidum subsp. pallidum SS14 riboflavin kinase/FMN adenylyltransferase YP_001933883.1 966928 R 455434 CDS YP_001933884.1 189026112 6333647 complement(967759..968859) 1 NC_010741.1 tRNA pseudouridine 55 synthase 968859 truB 6333647 truB Treponema pallidum subsp. pallidum SS14 tRNA pseudouridine 55 synthase YP_001933884.1 967759 R 455434 CDS YP_001933885.1 189026113 6333061 complement(968837..969217) 1 NC_010741.1 ribosome-binding factor A 969217 rbfA 6333061 rbfA Treponema pallidum subsp. pallidum SS14 ribosome-binding factor A YP_001933885.1 968837 R 455434 CDS YP_001933886.1 189026114 6333644 complement(969214..971742) 1 NC_010741.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 971742 infB 6333644 infB Treponema pallidum subsp. pallidum SS14 translation initiation factor IF-2 YP_001933886.1 969214 R 455434 CDS YP_001933887.1 189026115 6333648 complement(971918..973375) 1 NC_010741.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 973375 nusA 6333648 nusA Treponema pallidum subsp. pallidum SS14 transcription elongation factor NusA YP_001933887.1 971918 R 455434 CDS YP_001933888.1 189026116 6333646 complement(973425..973895) 1 NC_010741.1 hypothetical protein 973895 6333646 TPASS_0893 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933888.1 973425 R 455434 CDS YP_001933889.1 189026117 6333059 complement(974070..975092) 1 NC_010741.1 hypothetical protein 975092 6333059 TPASS_0894 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933889.1 974070 R 455434 CDS YP_001933890.1 189026118 6333645 complement(975099..975605) 1 NC_010741.1 hypothetical protein 975605 6333645 TPASS_0895 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933890.1 975099 R 455434 CDS YP_001933891.1 189026119 6333642 complement(975627..975779) 1 NC_010741.1 hypothetical protein 975779 6333642 TPASS_0896 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933891.1 975627 R 455434 CDS YP_001933892.1 189026120 6332833 complement(975761..977278) 1 NC_010741.1 this gene is heterogenous among individual cells in a population; believed to be under immune response pressure; not to determine a single unambiguous sequence; protein TprK 977278 tprK 6332833 tprK Treponema pallidum subsp. pallidum SS14 protein TprK YP_001933892.1 975761 R 455434 CDS YP_001933893.1 189026121 6333641 complement(977275..980994) 1 NC_010741.1 ATP-dependent nuclease, subunit A 980994 6333641 TPASS_0898 Treponema pallidum subsp. pallidum SS14 ATP-dependent nuclease, subunit A YP_001933893.1 977275 R 455434 CDS YP_001933894.1 189026122 6333640 complement(980991..981578) 1 NC_010741.1 hypothetical protein 981578 6333640 TPASS_0899 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933894.1 980991 R 455434 CDS YP_001933895.1 189026123 6333058 complement(981557..983950) 1 NC_010741.1 hypothetical protein 983950 6333058 TPASS_0900 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933895.1 981557 R 455434 CDS YP_001933896.1 189026124 6333638 complement(983989..985401) 1 NC_010741.1 hypothetical protein 985401 6333638 TPASS_0901 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933896.1 983989 R 455434 CDS YP_001933897.1 189026125 6332832 complement(985442..986323) 1 NC_010741.1 carboxylesterase 986323 est 6332832 est Treponema pallidum subsp. pallidum SS14 carboxylesterase YP_001933897.1 985442 R 455434 CDS YP_001933898.1 189026126 6333055 986325..987923 1 NC_010741.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase 987923 murD 6333055 murD Treponema pallidum subsp. pallidum SS14 UDP-N-acetylmuramoylalanine--D-glutamate ligase YP_001933898.1 986325 D 455434 CDS YP_001933899.1 189026127 6333639 987916..988167 1 NC_010741.1 hypothetical protein 988167 6333639 TPASS_0904 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933899.1 987916 D 455434 CDS YP_001933900.1 189026128 6332831 988130..988501 1 NC_010741.1 ribosomal protein S16 988501 rpsP 6332831 rpsP Treponema pallidum subsp. pallidum SS14 ribosomal protein S16 YP_001933900.1 988130 D 455434 CDS YP_001933901.1 189026129 6333635 988510..988752 1 NC_010741.1 hypothetical protein 988752 6333635 TPASS_0906 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933901.1 988510 D 455434 CDS YP_001933902.1 189026130 6333636 988815..989339 1 NC_010741.1 hypothetical protein 989339 6333636 TPASS_0907 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933902.1 988815 D 455434 CDS YP_001933903.1 189026131 6333637 989336..990088 1 NC_010741.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 990088 trmD 6333637 trmD Treponema pallidum subsp. pallidum SS14 tRNA (guanine-N(1)-)-methyltransferase YP_001933903.1 989336 D 455434 CDS YP_001933904.1 189026132 6333633 990060..990431 1 NC_010741.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 990431 rplS 6333633 rplS Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L19 YP_001933904.1 990060 D 455434 CDS YP_001933905.1 189026133 6333632 990428..991348 1 NC_010741.1 hypothetical protein 991348 6333632 TPASS_0910 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933905.1 990428 D 455434 CDS YP_001933906.1 189026134 6333054 991370..991621 1 NC_010741.1 hypothetical protein 991621 6333054 TPASS_0911 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933906.1 991370 D 455434 CDS YP_001933907.1 189026135 6333634 991634..992956 1 NC_010741.1 hypothetical protein 992956 6333634 TPASS_0912 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933907.1 991634 D 455434 CDS YP_001933908.1 189026136 6332830 992940..993320 1 NC_010741.1 hypothetical protein 993320 6332830 TPASS_0913 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933908.1 992940 D 455434 CDS YP_001933909.1 189026137 6333631 993492..993878 1 NC_010741.1 hypothetical protein 993878 6333631 TPASS_0914 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933909.1 993492 D 455434 CDS YP_001933910.1 189026138 6333052 993952..995286 1 NC_010741.1 hypothetical protein 995286 6333052 TPASS_0915 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933910.1 993952 D 455434 CDS YP_001933911.1 189026139 6333629 995343..995471 1 NC_010741.1 hypothetical protein 995471 6333629 TPASS_0916 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933911.1 995343 D 455434 CDS YP_001933912.1 189026140 6333628 995455..996804 1 NC_010741.1 Mg2+ transport protein 996804 mgtE 6333628 mgtE Treponema pallidum subsp. pallidum SS14 Mg2+ transport protein YP_001933912.1 995455 D 455434 CDS YP_001933913.1 189026141 6333630 996819..997592 1 NC_010741.1 hypothetical protein 997592 6333630 TPASS_0918 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933913.1 996819 D 455434 CDS YP_001933914.1 189026142 6332829 complement(997618..997935) 1 NC_010741.1 thioredoxin 997935 trx 6332829 trx Treponema pallidum subsp. pallidum SS14 thioredoxin YP_001933914.1 997618 R 455434 CDS YP_001933915.1 189026143 6333051 998158..1000587 1 NC_010741.1 hypothetical protein 1000587 6333051 TPASS_0920 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933915.1 998158 D 455434 CDS YP_001933916.1 189026144 6333626 1000695..1002032 1 NC_010741.1 NADH oxidase 1002032 6333626 TPASS_0921 Treponema pallidum subsp. pallidum SS14 NADH oxidase YP_001933916.1 1000695 D 455434 CDS YP_001933917.1 189026145 6333625 complement(1002166..1003059) 1 NC_010741.1 hypothetical protein 1003059 6333625 TPASS_0922 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933917.1 1002166 R 455434 CDS YP_001933918.1 189026146 6333048 complement(1003098..1004117) 1 NC_010741.1 hypothetical protein 1004117 6333048 TPASS_0923 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933918.1 1003098 R 455434 CDS YP_001933919.1 189026147 6332828 1004441..1006027 1 NC_010741.1 protein Tex 1006027 tex 6332828 tex Treponema pallidum subsp. pallidum SS14 protein Tex YP_001933919.1 1004441 D 455434 CDS YP_001933920.1 189026148 6333620 1007144..1007584 1 NC_010741.1 flavodoxin 1007584 6333620 TPASS_0925 Treponema pallidum subsp. pallidum SS14 flavodoxin YP_001933920.1 1007144 D 455434 CDS YP_001933921.1 189026149 6333621 complement(1007735..1009273) 1 NC_010741.1 signal peptidase I 1009273 6333621 TPASS_0926 Treponema pallidum subsp. pallidum SS14 signal peptidase I YP_001933921.1 1007735 R 455434 CDS YP_001933922.1 189026150 6333046 1009365..1009955 1 NC_010741.1 hypothetical protein 1009955 6333046 TPASS_0927 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933922.1 1009365 D 455434 CDS YP_001933923.1 189026151 6333045 1010050..1010790 1 NC_010741.1 hypothetical protein 1010790 6333045 TPASS_0928 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933923.1 1010050 D 455434 CDS YP_001933924.1 189026152 6332826 1010802..1011572 1 NC_010741.1 hypothetical protein 1011572 6332826 TPASS_0929 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933924.1 1010802 D 455434 CDS YP_001933925.1 189026153 6333616 1011596..1013317 1 NC_010741.1 hypothetical protein 1013317 6333616 TPASS_0930 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933925.1 1011596 D 455434 CDS YP_001933926.1 189026154 6333617 complement(1013401..1014831) 1 NC_010741.1 hypothetical protein 1014831 6333617 TPASS_0931 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933926.1 1013401 R 455434 CDS YP_001933927.1 189026155 6333619 complement(1014841..1014933) 1 NC_010741.1 hypothetical protein 1014933 6333619 TPASS_0932 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933927.1 1014841 R 455434 CDS YP_001933928.1 189026156 6333615 complement(1014943..1016565) 1 NC_010741.1 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 1016565 murE 6333615 murE Treponema pallidum subsp. pallidum SS14 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_001933928.1 1014943 R 455434 CDS YP_001933929.1 189026157 6333043 1016701..1017924 1 NC_010741.1 glutamate transporter 1017924 6333043 TPASS_0934 Treponema pallidum subsp. pallidum SS14 glutamate transporter YP_001933929.1 1016701 D 455434 CDS YP_001933930.1 189026158 6333613 complement(1017917..1018855) 1 NC_010741.1 N-acetylphosphinothricin-tripetide-deacetylase 1018855 6333613 TPASS_0935 Treponema pallidum subsp. pallidum SS14 N-acetylphosphinothricin-tripetide-deacetylase YP_001933930.1 1017917 R 455434 CDS YP_001933931.1 189026159 6333042 complement(1019049..1020122) 1 NC_010741.1 hemolysin 1020122 6333042 TPASS_0936 Treponema pallidum subsp. pallidum SS14 hemolysin YP_001933931.1 1019049 R 455434 CDS YP_001933932.1 189026160 6333609 complement(1020294..1020929) 1 NC_010741.1 hypothetical protein 1020929 6333609 TPASS_0937 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933932.1 1020294 R 455434 CDS YP_001933933.1 189026161 6333610 complement(1020926..1021756) 1 NC_010741.1 hypothetical protein 1021756 6333610 TPASS_0938 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933933.1 1020926 R 455434 CDS YP_001933934.1 189026162 6333612 complement(1021821..1025375) 1 NC_010741.1 pyruvate oxidoreductase 1025375 6333612 TPASS_0939 Treponema pallidum subsp. pallidum SS14 pyruvate oxidoreductase YP_001933934.1 1021821 R 455434 CDS YP_001933935.1 189026163 6332824 complement(1025391..1025531) 1 NC_010741.1 hypothetical protein 1025531 6332824 TPASS_0940 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933935.1 1025391 R 455434 CDS YP_001933936.1 189026164 6333607 complement(1025570..1026088) 1 NC_010741.1 hypothetical protein 1026088 6333607 TPASS_0941 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933936.1 1025570 R 455434 CDS YP_001933937.1 189026165 6333611 complement(1026165..1026629) 1 NC_010741.1 hypothetical protein 1026629 6333611 TPASS_0942 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933937.1 1026165 R 455434 CDS YP_001933938.1 189026166 6333041 complement(1026635..1027081) 1 NC_010741.1 flagellar protein 1027081 fliS 6333041 fliS Treponema pallidum subsp. pallidum SS14 flagellar protein YP_001933938.1 1026635 R 455434 CDS YP_001933939.1 189026167 6333040 complement(1027130..1028302) 1 NC_010741.1 hypothetical protein 1028302 6333040 TPASS_0944 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933939.1 1027130 R 455434 CDS YP_001933940.1 189026168 6333830 complement(1028473..1029129) 1 NC_010741.1 ribulose-phosphate 3-epimerase 1029129 cfxE 6333830 cfxE Treponema pallidum subsp. pallidum SS14 ribulose-phosphate 3-epimerase YP_001933940.1 1028473 R 455434 CDS YP_001933941.1 189026169 6333831 1029281..1029949 1 NC_010741.1 glucose-inhibited division protein B 1029949 gidB 6333831 gidB Treponema pallidum subsp. pallidum SS14 glucose-inhibited division protein B YP_001933941.1 1029281 D 455434 CDS YP_001933942.1 189026170 6332794 complement(1029994..1030641) 1 NC_010741.1 peptidyl-prolyl cis-trans isomerase, cyclophilin-binding 1030641 cyp 6332794 cyp Treponema pallidum subsp. pallidum SS14 peptidyl-prolyl cis-trans isomerase, cyclophilin-binding YP_001933942.1 1029994 R 455434 CDS YP_001933943.1 189026171 6333846 complement(1030638..1031333) 1 NC_010741.1 spoIIIJ-associated protein 1031333 jag 6333846 jag Treponema pallidum subsp. pallidum SS14 spoIIIJ-associated protein YP_001933943.1 1030638 R 455434 CDS YP_001933944.1 189026172 6333837 complement(1031349..1033346) 1 NC_010741.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 1033346 6333837 TPASS_0949 Treponema pallidum subsp. pallidum SS14 inner membrane protein translocase component YidC YP_001933944.1 1031349 R 455434 CDS YP_001933945.1 189026173 6333833 complement(1033622..1033906) 1 NC_010741.1 hypothetical protein 1033906 6333833 TPASS_0950 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933945.1 1033622 R 455434 CDS YP_001933946.1 189026174 6332887 complement(1033910..1034065) 1 NC_010741.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 1034065 rpmH 6332887 rpmH Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L34 YP_001933946.1 1033910 R 455434 CDS YP_001933947.1 189026175 6333849 complement(1034185..1035222) 1 NC_010741.1 lipase 1035222 6333849 TPASS_0952 Treponema pallidum subsp. pallidum SS14 lipase YP_001933947.1 1034185 R 455434 CDS YP_001933948.1 189026176 6333099 complement(1035304..1036494) 1 NC_010741.1 pheromone shutdown protein 1036494 traB 6333099 traB Treponema pallidum subsp. pallidum SS14 pheromone shutdown protein YP_001933948.1 1035304 R 455434 CDS YP_001933949.1 189026177 6332869 complement(1036581..1038017) 1 NC_010741.1 hypothetical protein 1038017 6332869 TPASS_0954 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933949.1 1036581 R 455434 CDS YP_001933950.1 189026178 6333111 complement(1038089..1038361) 1 NC_010741.1 hypothetical protein 1038361 6333111 TPASS_0955 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933950.1 1038089 R 455434 CDS YP_001933951.1 189026179 6333094 1038457..1039428 1 NC_010741.1 hypothetical protein 1039428 6333094 TPASS_0956 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933951.1 1038457 D 455434 CDS YP_001933952.1 189026180 6333124 1039519..1040547 1 NC_010741.1 protein Tp33 1040547 tp33 6333124 tp33 Treponema pallidum subsp. pallidum SS14 protein Tp33 YP_001933952.1 1039519 D 455434 CDS YP_001933953.1 189026181 6333143 1040579..1042477 1 NC_010741.1 dicarboxylate transporter 1042477 dctM 6333143 dctM Treponema pallidum subsp. pallidum SS14 dicarboxylate transporter YP_001933953.1 1040579 D 455434 CDS YP_001933954.1 189026182 6332970 complement(1042546..1042935) 1 NC_010741.1 hypothetical protein 1042935 6332970 TPASS_0959 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933954.1 1042546 R 455434 CDS YP_001933955.1 189026183 6333331 complement(1042947..1043741) 1 NC_010741.1 makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1043741 flgG 6333331 flgG Treponema pallidum subsp. pallidum SS14 flagellar basal body rod protein FlgG YP_001933955.1 1042947 R 455434 CDS YP_001933956.1 189026184 6333214 complement(1043817..1044632) 1 NC_010741.1 flagellar basal-body rod protein 1044632 flgG2 6333214 flgG2 Treponema pallidum subsp. pallidum SS14 flagellar basal-body rod protein YP_001933956.1 1043817 R 455434 CDS YP_001933957.1 189026185 6333182 complement(1044718..1045950) 1 NC_010741.1 hypothetical protein 1045950 6333182 TPASS_0962 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933957.1 1044718 R 455434 CDS YP_001933958.1 189026186 6333217 complement(1046061..1047290) 1 NC_010741.1 hypothetical protein 1047290 6333217 TPASS_0963 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933958.1 1046061 R 455434 CDS YP_001933959.1 189026187 6333220 complement(1047280..1047987) 1 NC_010741.1 ABC transporter, ATP-binding protein 1047987 6333220 TPASS_0964 Treponema pallidum subsp. pallidum SS14 ABC transporter, ATP-binding protein YP_001933959.1 1047280 R 455434 CDS YP_001933960.1 189026188 6333358 complement(1047987..1048949) 1 NC_010741.1 membrane fusion protein 1048949 6333358 TPASS_0965 Treponema pallidum subsp. pallidum SS14 membrane fusion protein YP_001933960.1 1047987 R 455434 CDS YP_001933961.1 189026189 6333296 complement(1048974..1050608) 1 NC_010741.1 hypothetical protein 1050608 6333296 TPASS_0966 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933961.1 1048974 R 455434 CDS YP_001933962.1 189026190 6333243 complement(1050655..1052208) 1 NC_010741.1 hypothetical protein 1052208 6333243 TPASS_0967 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933962.1 1050655 R 455434 CDS YP_001933963.1 189026191 6333257 complement(1052205..1053827) 1 NC_010741.1 hypothetical protein 1053827 6333257 TPASS_0968 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933963.1 1052205 R 455434 CDS YP_001933964.1 189026192 6333242 complement(1053824..1055443) 1 NC_010741.1 hypothetical protein 1055443 6333242 TPASS_0969 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933964.1 1053824 R 455434 CDS YP_001933965.1 189026193 6333556 complement(1055440..1055556) 1 NC_010741.1 hypothetical protein 1055556 6333556 TPASS_0970 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933965.1 1055440 R 455434 CDS YP_001933966.1 189026194 6333288 complement(1055578..1056192) 1 NC_010741.1 membrane antigen, pathogen-specific 1056192 tpd 6333288 tpd Treponema pallidum subsp. pallidum SS14 membrane antigen, pathogen-specific YP_001933966.1 1055578 R 455434 CDS YP_001933967.1 189026195 6333285 complement(1056348..1057694) 1 NC_010741.1 hypothetical protein 1057694 6333285 TPASS_0972 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933967.1 1056348 R 455434 CDS YP_001933968.1 189026196 6333239 1057782..1059443 1 NC_010741.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1059443 pheS 6333239 pheS Treponema pallidum subsp. pallidum SS14 phenylalanyl-tRNA synthetase subunit alpha YP_001933968.1 1057782 D 455434 CDS YP_001933969.1 189026197 6333283 complement(1059495..1059776) 1 NC_010741.1 hypothetical protein 1059776 6333283 TPASS_0974 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933969.1 1059495 R 455434 CDS YP_001933970.1 189026198 6333284 complement(1059828..1060652) 1 NC_010741.1 hypothetical protein 1060652 6333284 TPASS_0975 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933970.1 1059828 R 455434 CDS YP_001933971.1 189026199 6333286 1060700..1062079 1 NC_010741.1 hypothetical protein 1062079 6333286 TPASS_0976 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933971.1 1060700 D 455434 CDS YP_001933972.1 189026200 6333282 1062066..1062926 1 NC_010741.1 hypothetical protein 1062926 6333282 TPASS_0977 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933972.1 1062066 D 455434 CDS YP_001933973.1 189026201 6333240 1062923..1063516 1 NC_010741.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; signal peptidase II 1063516 lspA 6333240 lspA Treponema pallidum subsp. pallidum SS14 signal peptidase II YP_001933973.1 1062923 D 455434 CDS YP_001933974.1 189026202 6332912 1063686..1064459 1 NC_010741.1 hypothetical protein 1064459 6332912 TPASS_0979 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933974.1 1063686 D 455434 CDS YP_001933975.1 189026203 6332994 1064467..1065489 1 NC_010741.1 histidine phosphokinase/phophatase 1065489 ntrB 6332994 ntrB Treponema pallidum subsp. pallidum SS14 histidine phosphokinase/phophatase YP_001933975.1 1064467 D 455434 CDS YP_001933976.1 189026204 6333009 1065549..1066712 1 NC_010741.1 sensory transduction histidine kinase 1066712 6333009 TPASS_0981 Treponema pallidum subsp. pallidum SS14 sensory transduction histidine kinase YP_001933976.1 1065549 D 455434 CDS YP_001933977.1 189026205 6333006 1066728..1067354 1 NC_010741.1 protein GlpG 1067354 6333006 TPASS_0982 Treponema pallidum subsp. pallidum SS14 protein GlpG YP_001933977.1 1066728 D 455434 CDS YP_001933978.1 189026206 6332999 1067344..1068060 1 NC_010741.1 hypothetical protein 1068060 6332999 TPASS_0983 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933978.1 1067344 D 455434 CDS YP_001933979.1 189026207 6333023 complement(1068084..1070003) 1 NC_010741.1 molecular chaperone; heat shock protein 90 1070003 htpG 6333023 htpG Treponema pallidum subsp. pallidum SS14 heat shock protein 90 YP_001933979.1 1068084 R 455434 CDS YP_001933980.1 189026208 6333007 1070147..1071955 1 NC_010741.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1071955 aspS 6333007 aspS Treponema pallidum subsp. pallidum SS14 aspartyl-tRNA synthetase YP_001933980.1 1070147 D 455434 CDS YP_001933981.1 189026209 6333008 1072011..1072895 1 NC_010741.1 hypothetical protein 1072895 6333008 TPASS_0986 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933981.1 1072011 D 455434 CDS YP_001933982.1 189026210 6333031 complement(1072941..1073111) 1 NC_010741.1 hypothetical protein 1073111 6333031 TPASS_0987 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933982.1 1072941 R 455434 CDS YP_001933983.1 189026211 6333049 1073178..1074014 1 NC_010741.1 hypothetical protein 1074014 6333049 TPASS_0988 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933983.1 1073178 D 455434 CDS YP_001933984.1 189026212 6333090 complement(1074050..1074922) 1 NC_010741.1 protein P26 1074922 6333090 TPASS_0989 Treponema pallidum subsp. pallidum SS14 protein P26 YP_001933984.1 1074050 R 455434 CDS YP_001933985.1 189026213 6333035 1074969..1078070 1 NC_010741.1 hypothetical protein 1078070 6333035 TPASS_0990 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933985.1 1074969 D 455434 CDS YP_001933986.1 189026214 6333089 1078134..1078292 1 NC_010741.1 rubredoxin 1078292 6333089 TPASS_0991 Treponema pallidum subsp. pallidum SS14 rubredoxin YP_001933986.1 1078134 D 455434 CDS YP_001933987.1 189026215 6333237 1078325..1078612 1 NC_010741.1 hypothetical protein 1078612 6333237 TPASS_0992 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933987.1 1078325 D 455434 CDS YP_001933988.1 189026216 6333223 complement(1078749..1079705) 1 NC_010741.1 rare lipoprotein A 1079705 6333223 TPASS_0993 Treponema pallidum subsp. pallidum SS14 rare lipoprotein A YP_001933988.1 1078749 R 455434 CDS YP_001933989.1 189026217 6333256 1080061..1080870 1 NC_010741.1 hypothetical protein 1080870 6333256 TPASS_0994 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933989.1 1080061 D 455434 CDS YP_001933990.1 189026218 6333225 1080946..1082232 1 NC_010741.1 cyclic nucleotide binding protein 1082232 6333225 TPASS_0995 Treponema pallidum subsp. pallidum SS14 cyclic nucleotide binding protein YP_001933990.1 1080946 D 455434 CDS YP_001933991.1 189026219 6333301 complement(1082315..1083931) 1 NC_010741.1 hypothetical protein 1083931 6333301 TPASS_0996 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933991.1 1082315 R 455434 CDS YP_001933992.1 189026220 6333863 complement(1084088..1085884) 1 NC_010741.1 protease IV 1085884 sppA 6333863 sppA Treponema pallidum subsp. pallidum SS14 protease IV YP_001933992.1 1084088 R 455434 CDS YP_001933993.1 189026221 6333252 complement(1085918..1087420) 1 NC_010741.1 sodium/proton-dependent alanine transporter 1087420 6333252 TPASS_0998 Treponema pallidum subsp. pallidum SS14 sodium/proton-dependent alanine transporter YP_001933993.1 1085918 R 455434 CDS YP_001933994.1 189026222 6333066 1087492..1089891 1 NC_010741.1 cell division protein 1089891 6333066 TPASS_0999 Treponema pallidum subsp. pallidum SS14 cell division protein YP_001933994.1 1087492 D 455434 CDS YP_001933995.1 189026223 6333253 1090069..1090740 1 NC_010741.1 hypothetical protein 1090740 6333253 TPASS_1000 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933995.1 1090069 D 455434 CDS YP_001933996.1 189026224 6333297 complement(1090880..1092061) 1 NC_010741.1 hypothetical protein 1092061 6333297 TPASS_1001 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933996.1 1090880 R 455434 CDS YP_001933997.1 189026225 6333862 complement(1092075..1092743) 1 NC_010741.1 hypothetical protein 1092743 6333862 TPASS_1002 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933997.1 1092075 R 455434 CDS YP_001933998.1 189026226 6333255 1092938..1093975 1 NC_010741.1 hypothetical protein 1093975 6333255 TPASS_1003 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001933998.1 1092938 D 455434 CDS YP_001933999.1 189026227 6333663 complement(1093998..1094603) 1 NC_010741.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1094603 recR 6333663 recR Treponema pallidum subsp. pallidum SS14 recombination protein RecR YP_001933999.1 1093998 R 455434 CDS YP_001934000.1 189026228 6333333 complement(1094677..1096395) 1 NC_010741.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 1096395 dnaZX 6333333 dnaZX Treponema pallidum subsp. pallidum SS14 DNA polymerase III subunits gamma and tau YP_001934000.1 1094677 R 455434 CDS YP_001934001.1 189026229 6333298 complement(1096454..1098367) 1 NC_010741.1 DNA gyrase, subunit B 1098367 gyrB 6333298 gyrB Treponema pallidum subsp. pallidum SS14 DNA gyrase, subunit B YP_001934001.1 1096454 R 455434 CDS YP_001934002.1 189026230 6333303 complement(1098476..1099393) 1 NC_010741.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase 1099393 thyX 6333303 thyX Treponema pallidum subsp. pallidum SS14 FAD-dependent thymidylate synthase YP_001934002.1 1098476 R 455434 CDS YP_001934003.1 189026231 6333342 complement(1099436..1101973) 1 NC_010741.1 catalyzes the rate limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1101973 nrdA 6333342 nrdA Treponema pallidum subsp. pallidum SS14 ribonucleotide-diphosphate reductase subunit alpha YP_001934003.1 1099436 R 455434 CDS YP_001934004.1 189026232 6333865 complement(1102100..1103170) 1 NC_010741.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1103170 gpsA 6333865 gpsA Treponema pallidum subsp. pallidum SS14 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_001934004.1 1102100 R 455434 CDS YP_001934005.1 189026233 6333350 complement(1103267..1103716) 1 NC_010741.1 nucleoside-diphosphate kinase 1103716 ndk 6333350 ndk Treponema pallidum subsp. pallidum SS14 nucleoside-diphosphate kinase YP_001934005.1 1103267 R 455434 CDS YP_001934006.1 189026234 6333872 complement(1103842..1104450) 1 NC_010741.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1104450 pth 6333872 pth Treponema pallidum subsp. pallidum SS14 peptidyl-tRNA hydrolase YP_001934006.1 1103842 R 455434 CDS YP_001934007.1 189026235 6333850 complement(1104485..1105420) 1 NC_010741.1 RNA polymerase sigma-43 factor 1105420 sigA 6333850 sigA Treponema pallidum subsp. pallidum SS14 RNA polymerase sigma-43 factor YP_001934007.1 1104485 R 455434 CDS YP_001934008.1 189026236 6333859 1105625..1105891 1 NC_010741.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1105891 groES 6333859 groES Treponema pallidum subsp. pallidum SS14 co-chaperonin GroES YP_001934008.1 1105625 D 455434 CDS YP_001934009.1 189026237 6333873 complement(1105902..1107836) 1 NC_010741.1 hypothetical protein 1107836 6333873 TPASS_1014 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001934009.1 1105902 R 455434 CDS YP_001934010.1 189026238 6333855 complement(1107802..1108227) 1 NC_010741.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 1108227 nusB 6333855 nusB Treponema pallidum subsp. pallidum SS14 transcription antitermination protein NusB YP_001934010.1 1107802 R 455434 CDS YP_001934011.1 189026239 6333864 complement(1108224..1109309) 1 NC_010741.1 basic membrane protein 1109309 tpn39b 6333864 tpn39b Treponema pallidum subsp. pallidum SS14 basic membrane protein YP_001934011.1 1108224 R 455434 CDS YP_001934012.1 189026240 6333337 complement(1109382..1111199) 1 NC_010741.1 catalyzes a two-step reaction, first charging an alanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1111199 alaS 6333337 alaS Treponema pallidum subsp. pallidum SS14 alanyl-tRNA synthetase YP_001934012.1 1109382 R 455434 CDS YP_001934013.1 189026241 6333868 1111371..1112885 1 NC_010741.1 hypothetical protein 1112885 6333868 TPASS_1018 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001934013.1 1111371 D 455434 CDS YP_001934014.1 189026242 6333267 1112907..1113350 1 NC_010741.1 glu-tRNA amidotransferase, subunit C 1113350 gatC 6333267 gatC Treponema pallidum subsp. pallidum SS14 glu-tRNA amidotransferase, subunit C YP_001934014.1 1112907 D 455434 CDS YP_001934015.1 189026243 6332795 1113351..1114871 1 NC_010741.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 1114871 gatA 6332795 gatA Treponema pallidum subsp. pallidum SS14 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_001934015.1 1113351 D 455434 CDS YP_001934016.1 189026244 6332792 1114864..1116393 1 NC_010741.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 1116393 gatB 6332792 gatB Treponema pallidum subsp. pallidum SS14 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_001934016.1 1114864 D 455434 CDS YP_001934017.1 189026245 6333348 complement(1116489..1117856) 1 NC_010741.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 1117856 sms 6333348 sms Treponema pallidum subsp. pallidum SS14 DNA repair protein RadA YP_001934017.1 1116489 R 455434 CDS YP_001934018.1 189026246 6333338 complement(1117903..1118397) 1 NC_010741.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1118397 recX 6333338 recX Treponema pallidum subsp. pallidum SS14 recombination regulator RecX YP_001934018.1 1117903 R 455434 CDS YP_001934019.1 189026247 6333313 complement(1118525..1118914) 1 NC_010741.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 1118914 rpsI 6333313 rpsI Treponema pallidum subsp. pallidum SS14 30S ribosomal protein S9 YP_001934019.1 1118525 R 455434 CDS YP_001934020.1 189026248 6333234 complement(1118930..1119358) 1 NC_010741.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 1119358 rplM 6333234 rplM Treponema pallidum subsp. pallidum SS14 50S ribosomal protein L13 YP_001934020.1 1118930 R 455434 CDS YP_001934021.1 189026249 6333340 1119791..1121560 1 NC_010741.1 oligoendopeptidase F 1121560 6333340 TPASS_1026 Treponema pallidum subsp. pallidum SS14 oligoendopeptidase F YP_001934021.1 1119791 D 455434 CDS YP_001934022.1 189026250 6333343 1121682..1122458 1 NC_010741.1 uridine phosphorylase 1122458 udp 6333343 udp Treponema pallidum subsp. pallidum SS14 uridine phosphorylase YP_001934022.1 1121682 D 455434 CDS YP_001934023.1 189026251 6333273 complement(1122474..1124486) 1 NC_010741.1 DNA helicase II 1124486 uvrD 6333273 uvrD Treponema pallidum subsp. pallidum SS14 DNA helicase II YP_001934023.1 1122474 R 455434 CDS YP_001934024.1 189026252 6333264 complement(1124569..1125255) 1 NC_010741.1 hypothetical protein 1125255 6333264 TPASS_1029 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001934024.1 1124569 R 455434 CDS YP_001934025.1 189026253 6333231 complement(1125413..1125772) 1 NC_010741.1 hypothetical protein 1125772 6333231 TPASS_1030 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001934025.1 1125413 R 455434 CDS YP_001934026.1 189026254 6332791 1125800..1127344 1 NC_010741.1 protein TprL 1127344 tprL 6332791 tprL Treponema pallidum subsp. pallidum SS14 protein TprL YP_001934026.1 1125800 D 455434 CDS YP_001934027.1 189026255 6333263 complement(1127412..1127846) 1 NC_010741.1 hypothetical protein 1127846 6333263 TPASS_1032 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001934027.1 1127412 R 455434 CDS YP_001934028.1 189026256 6333866 complement(1127858..1128793) 1 NC_010741.1 hypothetical protein 1128793 6333866 TPASS_1033 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001934028.1 1127858 R 455434 CDS YP_001934029.1 189026257 6333278 1128867..1129892 1 NC_010741.1 hypothetical protein 1129892 6333278 TPASS_1034 Treponema pallidum subsp. pallidum SS14 hypothetical protein YP_001934029.1 1128867 D 455434 CDS YP_001934030.1 189026258 6333341 complement(1129889..1132759) 1 NC_010741.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 1132759 valS 6333341 valS Treponema pallidum subsp. pallidum SS14 valyl-tRNA synthetase YP_001934030.1 1129889 R 455434 CDS YP_001934031.1 189026259 6333259 1132912..1135290 1 NC_010741.1 cation-transporting ATPase, P-type 1135290 6333259 TPASS_1036 Treponema pallidum subsp. pallidum SS14 cation-transporting ATPase, P-type YP_001934031.1 1132912 D 455434 CDS YP_001934032.1 189026260 6333314 complement(1135380..1136096) 1 NC_010741.1 hemolysin III 1136096 hlyIII 6333314 hlyIII Treponema pallidum subsp. pallidum SS14 hemolysin III YP_001934032.1 1135380 R 455434 CDS YP_001934033.1 189026261 6333279 complement(1136255..1136788) 1 NC_010741.1 bacterioferrin TpF1 1136788 tpF1 6333279 tpF1 Treponema pallidum subsp. pallidum SS14 bacterioferrin TpF1 YP_001934033.1 1136255 R 455434 CDS YP_001934034.1 189026262 6333312 1137015..1137587 1 NC_010741.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1137587 apt 6333312 apt Treponema pallidum subsp. pallidum SS14 adenine phosphoribosyltransferase YP_001934034.1 1137015 D 455434 CDS YP_001934035.1 189026263 6333319 complement(1137610..1138665) 1 NC_010741.1 lysyl-tRNA synthetase 1138665 lysS2 6333319 lysS2 Treponema pallidum subsp. pallidum SS14 lysyl-tRNA synthetase YP_001934035.1 1137610 R 455434 CDS YP_001934036.1 189026264 6333309 complement(1138665..1139378) 1 NC_010741.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 1139378 clpP 6333309 clpP Treponema pallidum subsp. pallidum SS14 ATP-dependent Clp protease proteolytic subunit YP_001934036.1 1138665 R 455434 CDS