-- dump date   	20111121_015458
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
869209000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
869209000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209000003	Walker A motif; other site
869209000004	ATP binding site [chemical binding]; other site
869209000005	Walker B motif; other site
869209000006	arginine finger; other site
869209000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
869209000008	DnaA box-binding interface [nucleotide binding]; other site
869209000009	DNA polymerase III subunit beta; Provisional; Region: PRK14940
869209000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140
869209000011	putative DNA binding surface [nucleotide binding]; other site
869209000012	dimer interface [polypeptide binding]; other site
869209000013	beta-clamp/clamp loader binding surface; other site
869209000014	beta-clamp/translesion DNA polymerase binding surface; other site
869209000015	recombination protein F; Reviewed; Region: recF; PRK00064
869209000016	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209000017	Walker A/P-loop; other site
869209000018	ATP binding site [chemical binding]; other site
869209000019	Q-loop/lid; other site
869209000020	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209000021	ABC transporter signature motif; other site
869209000022	Walker B; other site
869209000023	D-loop; other site
869209000024	H-loop/switch region; other site
869209000025	Protein of unknown function (DUF721); Region: DUF721; cl02324
869209000026	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
869209000027	Domain of unknown function DUF37; Region: DUF37; cl00506
869209000028	membrane protein insertase; Provisional; Region: PRK01318
869209000029	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
869209000030	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
869209000031	G-X-X-G motif; other site
869209000032	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
869209000033	RxxxH motif; other site
869209000034	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
869209000035	active site
869209000036	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
869209000037	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
869209000038	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
869209000039	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
869209000040	DNA-binding site [nucleotide binding]; DNA binding site
869209000041	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
869209000042	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
869209000043	catalytic residue [active]
869209000044	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
869209000045	active site
869209000046	catalytic motif [active]
869209000047	Zn binding site [ion binding]; other site
869209000048	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
869209000049	Protein of unknown function (DUF2400); Region: DUF2400; cl09884
869209000050	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
869209000051	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
869209000052	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
869209000053	catalytic site [active]
869209000054	subunit interface [polypeptide binding]; other site
869209000055	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
869209000056	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
869209000057	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
869209000058	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
869209000059	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
869209000060	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
869209000061	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
869209000062	IMP binding site; other site
869209000063	dimer interface [polypeptide binding]; other site
869209000064	interdomain contacts; other site
869209000065	partial ornithine binding site; other site
869209000066	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
869209000067	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
869209000068	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
869209000069	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209000070	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
869209000071	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209000072	TIGR03545 family protein; Region: TIGR03545
869209000073	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
869209000074	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
869209000075	NMT1/THI5 like; Region: NMT1; pfam09084
869209000076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
869209000077	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
869209000078	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209000079	Walker A/P-loop; other site
869209000080	ATP binding site [chemical binding]; other site
869209000081	Q-loop/lid; other site
869209000082	ABC transporter signature motif; other site
869209000083	Walker B; other site
869209000084	D-loop; other site
869209000085	H-loop/switch region; other site
869209000086	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
869209000087	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
869209000088	putative substrate binding site [chemical binding]; other site
869209000089	putative ATP binding site [chemical binding]; other site
869209000090	LrgA family; Region: LrgA; cl00608
869209000091	LrgB-like family; Region: LrgB; cl00596
869209000092	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
869209000093	nucleotide binding site [chemical binding]; other site
869209000094	homotetrameric interface [polypeptide binding]; other site
869209000095	putative phosphate binding site [ion binding]; other site
869209000096	putative allosteric binding site; other site
869209000097	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
869209000098	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209000099	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
869209000100	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
869209000101	MatE; Region: MatE; cl10513
869209000102	MatE; Region: MatE; cl10513
869209000103	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
869209000104	ligand binding site [chemical binding]; other site
869209000105	Low molecular weight phosphatase family; Region: LMWPc; cd00115
869209000106	Active site [active]
869209000107	Transcriptional regulator [Transcription]; Region: LysR; COG0583
869209000108	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209000109	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
869209000110	dimerization interface [polypeptide binding]; other site
869209000111	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
869209000112	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
869209000113	homodimer interface [polypeptide binding]; other site
869209000114	substrate-cofactor binding pocket; other site
869209000115	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869209000116	catalytic residue [active]
869209000117	pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180
869209000118	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
869209000119	active site
869209000120	multimer interface [polypeptide binding]; other site
869209000121	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
869209000122	predicted active site [active]
869209000123	catalytic triad [active]
869209000124	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
869209000125	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
869209000126	putative active site [active]
869209000127	catalytic site [active]
869209000128	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
869209000129	putative active site [active]
869209000130	catalytic site [active]
869209000131	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
869209000132	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal...; Region: PurM-like; cl10019
869209000133	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203
869209000134	dimerization interface [polypeptide binding]; other site
869209000135	ATP binding site [chemical binding]; other site
869209000136	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204
869209000137	dimerization interface [polypeptide binding]; other site
869209000138	ATP binding site [chemical binding]; other site
869209000139	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
869209000140	conserved cys residue [active]
869209000141	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
869209000142	Domain of unknown function DUF21; Region: DUF21; pfam01595
869209000143	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
869209000144	Transporter associated domain; Region: CorC_HlyC; cl08393
869209000145	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
869209000146	Domain of unknown function DUF21; Region: DUF21; pfam01595
869209000147	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
869209000148	Transporter associated domain; Region: CorC_HlyC; cl08393
869209000149	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102
869209000150	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
869209000151	active site
869209000152	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
869209000153	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
869209000154	Walker A/P-loop; other site
869209000155	ATP binding site [chemical binding]; other site
869209000156	Q-loop/lid; other site
869209000157	ABC transporter signature motif; other site
869209000158	Walker B; other site
869209000159	D-loop; other site
869209000160	H-loop/switch region; other site
869209000161	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
869209000162	ABC-ATPase subunit  interface; other site
869209000163	dimer interface [polypeptide binding]; other site
869209000164	putative PBP binding regions; other site
869209000165	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144
869209000166	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
869209000167	cobalamin binding residues [chemical binding]; other site
869209000168	putative BtuC binding residues; other site
869209000169	dimer interface [polypeptide binding]; other site
869209000170	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
869209000171	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
869209000172	Putative carbohydrate binding domain; Region: CBM_X; cl05621
869209000173	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
869209000174	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
869209000175	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
869209000176	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
869209000177	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
869209000178	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
869209000179	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
869209000180	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
869209000181	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209000182	dimer interface [polypeptide binding]; other site
869209000183	conserved gate region; other site
869209000184	putative PBP binding loops; other site
869209000185	ABC-ATPase subunit interface; other site
869209000186	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
869209000187	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
869209000188	inhibitor binding site; inhibition site
869209000189	active site
869209000190	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
869209000191	Transcriptional regulators [Transcription]; Region: PurR; COG1609
869209000192	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
869209000193	DNA binding site [nucleotide binding]
869209000194	domain linker motif; other site
869209000195	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
869209000196	dimerization interface [polypeptide binding]; other site
869209000197	ligand binding site [chemical binding]; other site
869209000198	Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494
869209000199	recombination protein RecR; Reviewed; Region: recR; PRK00076
869209000200	RecR protein; Region: RecR; pfam02132
869209000201	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
869209000202	putative active site [active]
869209000203	putative metal-binding site [ion binding]; other site
869209000204	tetramer interface [polypeptide binding]; other site
869209000205	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
869209000206	Peptidase family M48; Region: Peptidase_M48; cl12018
869209000207	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
869209000208	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
869209000209	S-adenosylmethionine binding site [chemical binding]; other site
869209000210	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
869209000211	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
869209000212	dimerization interface [polypeptide binding]; other site
869209000213	domain crossover interface; other site
869209000214	redox-dependent activation switch; other site
869209000215	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
869209000216	C-terminal peptidase (prc); Region: prc; TIGR00225
869209000217	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
869209000218	protein binding site [polypeptide binding]; other site
869209000219	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
869209000220	Catalytic dyad [active]
869209000221	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
869209000222	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270
869209000223	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209000224	Walker A motif; other site
869209000225	ATP binding site [chemical binding]; other site
869209000226	Walker B motif; other site
869209000227	arginine finger; other site
869209000228	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
869209000229	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
869209000230	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
869209000231	anti sigma factor interaction site; other site
869209000232	regulatory phosphorylation site [posttranslational modification]; other site
869209000233	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
869209000234	E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572
869209000235	NAD binding site [chemical binding]; other site
869209000236	dimerization interface [polypeptide binding]; other site
869209000237	product binding site; other site
869209000238	substrate binding site [chemical binding]; other site
869209000239	zinc binding site [ion binding]; other site
869209000240	catalytic residues [active]
869209000241	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487
869209000242	active site
869209000243	catalytic residues [active]
869209000244	metal binding site [ion binding]; metal-binding site
869209000245	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
869209000246	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
869209000247	putative active site [active]
869209000248	substrate binding site [chemical binding]; other site
869209000249	putative cosubstrate binding site; other site
869209000250	catalytic site [active]
869209000251	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
869209000252	substrate binding site [chemical binding]; other site
869209000253	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
869209000254	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
869209000255	Acetokinase family; Region: Acetate_kinase; cl01029
869209000256	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
869209000257	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
869209000258	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209000259	Walker A/P-loop; other site
869209000260	ATP binding site [chemical binding]; other site
869209000261	Q-loop/lid; other site
869209000262	ABC transporter signature motif; other site
869209000263	Walker B; other site
869209000264	D-loop; other site
869209000265	H-loop/switch region; other site
869209000266	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
869209000267	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
869209000268	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209000269	Aspartate carbamoyltransferase, regulatory subunit [Nucleotide transport and metabolism]; Region: PyrI; COG1781
869209000270	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
869209000271	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
869209000272	biotin synthase; Validated; Region: PRK06256
869209000273	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
869209000274	FeS/SAM binding site; other site
869209000275	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
869209000276	Cobalt transport protein; Region: CbiQ; cl00463
869209000277	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
869209000278	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
869209000279	Walker A/P-loop; other site
869209000280	ATP binding site [chemical binding]; other site
869209000281	Q-loop/lid; other site
869209000282	ABC transporter signature motif; other site
869209000283	Walker B; other site
869209000284	D-loop; other site
869209000285	H-loop/switch region; other site
869209000286	BioY family; Region: BioY; cl00560
869209000287	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209000288	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
869209000289	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
869209000290	Transcriptional regulator [Transcription]; Region: LysR; COG0583
869209000291	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209000292	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
869209000293	dimerization interface [polypeptide binding]; other site
869209000294	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
869209000295	substrate binding site [chemical binding]; other site
869209000296	ATP binding site [chemical binding]; other site
869209000297	EamA-like transporter family; Region: EamA; cl01037
869209000298	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
869209000299	EamA-like transporter family; Region: EamA; cl01037
869209000300	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
869209000301	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209000302	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209000303	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
869209000304	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-...; Region: DHOD_e_trans_like1; cd06219
869209000305	FAD binding pocket [chemical binding]; other site
869209000306	FAD binding motif [chemical binding]; other site
869209000307	phosphate binding motif [ion binding]; other site
869209000308	beta-alpha-beta structure motif; other site
869209000309	NAD binding pocket [chemical binding]; other site
869209000310	Iron coordination center [ion binding]; other site
869209000311	ferredoxin; Validated; Region: PRK07118
869209000312	hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512
869209000313	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
869209000314	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
869209000315	MgtC family; Region: MgtC; cl12207
869209000316	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195
869209000317	Domain of unknown function DUF87; Region: DUF87; pfam01935
869209000318	AAA-like domain; Region: AAA_10; pfam12846
869209000319	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
869209000320	MatE; Region: MatE; cl10513
869209000321	MatE; Region: MatE; cl10513
869209000322	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
869209000323	Transposase; Region: DEDD_Tnp_IS110; pfam01548
869209000324	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
869209000325	Z1 domain; Region: Z1; pfam10593
869209000326	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
869209000327	cofactor binding site; other site
869209000328	DNA binding site [nucleotide binding]
869209000329	substrate interaction site [chemical binding]; other site
869209000330	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209000331	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869209000332	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209000333	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209000334	Protein of unknown function (DUF3781); Region: DUF3781; pfam12636
869209000335	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
869209000336	Protein of unknown function (DUF419); Region: DUF419; cl15265
869209000337	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
869209000338	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209000339	Walker A/P-loop; other site
869209000340	ATP binding site [chemical binding]; other site
869209000341	Q-loop/lid; other site
869209000342	ABC transporter signature motif; other site
869209000343	Walker B; other site
869209000344	D-loop; other site
869209000345	H-loop/switch region; other site
869209000346	ABC transporter; Region: ABC_tran_2; pfam12848
869209000347	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
869209000348	NAD-dependent deacetylase; Provisional; Region: PRK14138
869209000349	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2-fam; cd01407
869209000350	NAD+ binding site [chemical binding]; other site
869209000351	substrate binding site [chemical binding]; other site
869209000352	Zn binding site [ion binding]; other site
869209000353	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209
869209000354	folate binding site [chemical binding]; other site
869209000355	NADP+ binding site [chemical binding]; other site
869209000356	histidinol-phosphatase; Provisional; Region: PRK07328
869209000357	pyruvate phosphate dikinase; Provisional; Region: PRK09279
869209000358	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
869209000359	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
869209000360	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
869209000361	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209000362	non-specific DNA binding site [nucleotide binding]; other site
869209000363	salt bridge; other site
869209000364	sequence-specific DNA binding site [nucleotide binding]; other site
869209000365	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464
869209000366	putative dimer interface [polypeptide binding]; other site
869209000367	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
869209000368	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
869209000369	asparagine synthetase B; Provisional; Region: asnB; PRK09431
869209000370	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
869209000371	active site
869209000372	dimer interface [polypeptide binding]; other site
869209000373	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes...; Region: Asn_Synthase_B_C; cd01991
869209000374	Ligand Binding Site [chemical binding]; other site
869209000375	Molecular Tunnel; other site
869209000376	Flagellin N-methylase; Region: FliB; cl00497
869209000377	Uncharacterized conserved protein [Function unknown]; Region: COG1284
869209000378	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
869209000379	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
869209000380	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
869209000381	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
869209000382	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209000383	DNA polymerase III subunits gamma and tau; Validated; Region: PRK06647
869209000384	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209000385	Walker A motif; other site
869209000386	ATP binding site [chemical binding]; other site
869209000387	Walker B motif; other site
869209000388	arginine finger; other site
869209000389	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
869209000390	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
869209000391	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
869209000392	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
869209000393	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427
869209000394	Late embryogenesis abundant protein; Region: LEA_2; cl12118
869209000395	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
869209000396	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209000397	dimer interface [polypeptide binding]; other site
869209000398	conserved gate region; other site
869209000399	putative PBP binding loops; other site
869209000400	ABC-ATPase subunit interface; other site
869209000401	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
869209000402	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
869209000403	Walker A/P-loop; other site
869209000404	ATP binding site [chemical binding]; other site
869209000405	Q-loop/lid; other site
869209000406	ABC transporter signature motif; other site
869209000407	Walker B; other site
869209000408	D-loop; other site
869209000409	H-loop/switch region; other site
869209000410	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
869209000411	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
869209000412	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
869209000413	Walker A/P-loop; other site
869209000414	ATP binding site [chemical binding]; other site
869209000415	Q-loop/lid; other site
869209000416	ABC transporter signature motif; other site
869209000417	Walker B; other site
869209000418	D-loop; other site
869209000419	H-loop/switch region; other site
869209000420	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
869209000421	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
869209000422	ATP cone domain; Region: ATP-cone; pfam03477
869209000423	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
869209000424	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
869209000425	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
869209000426	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
869209000427	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209000428	active site
869209000429	phosphorylation site [posttranslational modification]
869209000430	intermolecular recognition site; other site
869209000431	dimerization interface [polypeptide binding]; other site
869209000432	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
869209000433	DNA binding residues [nucleotide binding]
869209000434	dimerization interface [polypeptide binding]; other site
869209000435	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
869209000436	oligomeric interface; other site
869209000437	putative active site [active]
869209000438	homodimer interface [polypeptide binding]; other site
869209000439	Phd_YefM; Region: PhdYeFM; cl09153
869209000440	RelB antitoxin; Region: RelB; cl01171
869209000441	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593
869209000442	dimerization interface [polypeptide binding]; other site
869209000443	active site
869209000444	metal binding site [ion binding]; metal-binding site
869209000445	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048
869209000446	dsRNA binding site [nucleotide binding]; other site
869209000447	Competence protein CoiA-like family; Region: CoiA; cl11541
869209000448	PEGA domain; Region: PEGA; pfam08308
869209000449	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
869209000450	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
869209000451	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
869209000452	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
869209000453	ring oligomerisation interface [polypeptide binding]; other site
869209000454	ATP/Mg binding site [chemical binding]; other site
869209000455	stacking interactions; other site
869209000456	hinge regions; other site
869209000457	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
869209000458	Pyruvate formate lyase 1; Region: PFL1; cd01678
869209000459	coenzyme A binding site [chemical binding]; other site
869209000460	active site
869209000461	catalytic residues [active]
869209000462	glycine loop; other site
869209000463	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
869209000464	active site
869209000465	DNA binding site [nucleotide binding]
869209000466	putative phosphate binding site [ion binding]; other site
869209000467	putative catalytic site [active]
869209000468	metal binding site A [ion binding]; metal-binding site
869209000469	AP binding site [nucleotide binding]; other site
869209000470	metal binding site B [ion binding]; metal-binding site
869209000471	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
869209000472	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
869209000473	FeS/SAM binding site; other site
869209000474	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
869209000475	M28, and M42; Region: Zinc_peptidase_like; cl14876
869209000476	peptidase T; Region: peptidase-T; TIGR01882
869209000477	metal binding site [ion binding]; metal-binding site
869209000478	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369
869209000479	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
869209000480	hinge; other site
869209000481	active site
869209000482	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
869209000483	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
869209000484	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
869209000485	active site
869209000486	dimer interface [polypeptide binding]; other site
869209000487	motif 1; other site
869209000488	motif 2; other site
869209000489	motif 3; other site
869209000490	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266
869209000491	anticodon binding site; other site
869209000492	NlpC/P60 family; Region: NLPC_P60; cl11438
869209000493	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
869209000494	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
869209000495	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209000496	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
869209000497	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
869209000498	Transcriptional regulators [Transcription]; Region: PurR; COG1609
869209000499	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
869209000500	DNA binding site [nucleotide binding]
869209000501	domain linker motif; other site
869209000502	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
869209000503	ligand binding site [chemical binding]; other site
869209000504	dimerization interface [polypeptide binding]; other site
869209000505	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
869209000506	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
869209000507	Uncharacterized conserved protein [Function unknown]; Region: COG1306
869209000508	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
869209000509	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
869209000510	TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes.  It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes.  TrmE contains a GTPase...; Region: trmE; cd04164
869209000511	G1 box; other site
869209000512	GTP/Mg2+ binding site [chemical binding]; other site
869209000513	Switch I region; other site
869209000514	G2 box; other site
869209000515	Switch II region; other site
869209000516	G3 box; other site
869209000517	G4 box; other site
869209000518	G5 box; other site
869209000519	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
869209000520	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
869209000521	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
869209000522	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
869209000523	ligand binding site [chemical binding]; other site
869209000524	flexible hinge region; other site
869209000525	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
869209000526	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
869209000527	ligand binding site [chemical binding]; other site
869209000528	flexible hinge region; other site
869209000529	Flavin Reductases; Region: FlaRed; cl00801
869209000530	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464
869209000531	ADP binding site [chemical binding]; other site
869209000532	magnesium binding site [ion binding]; other site
869209000533	putative shikimate binding site; other site
869209000534	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
869209000535	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
869209000536	active site
869209000537	nucleophile elbow; other site
869209000538	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
869209000539	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
869209000540	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
869209000541	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685
869209000542	RNA binding site [nucleotide binding]; other site
869209000543	HsdM N-terminal domain; Region: HsdM_N; pfam12161
869209000544	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
869209000545	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
869209000546	S-adenosylmethionine binding site [chemical binding]; other site
869209000547	ORF6N domain; Region: ORF6N; pfam10543
869209000548	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
869209000549	catalytic site [active]
869209000550	Protein of unknown function (DUF1016); Region: DUF1016; cl01979
869209000551	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869209000552	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
869209000553	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869209000554	putative transposase OrfB; Reviewed; Region: PHA02517
869209000555	Integrase core domain; Region: rve; cl01316
869209000556	Fic family protein [Function unknown]; Region: COG3177
869209000557	Fic/DOC family; Region: Fic; cl00960
869209000558	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209000559	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
869209000560	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
869209000561	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869209000562	ATP binding site [chemical binding]; other site
869209000563	putative Mg++ binding site [ion binding]; other site
869209000564	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
869209000565	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
869209000566	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
869209000567	Outer membrane efflux protein; Region: OEP; pfam02321
869209000568	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
869209000569	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404
869209000570	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
869209000571	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
869209000572	Protein export membrane protein; Region: SecD_SecF; cl14618
869209000573	CTP synthetase; Validated; Region: pyrG; PRK05380
869209000574	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113
869209000575	Catalytic site [active]
869209000576	Active site [active]
869209000577	UTP binding site [chemical binding]; other site
869209000578	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
869209000579	active site
869209000580	putative oxyanion hole; other site
869209000581	catalytic triad [active]
869209000582	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
869209000583	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209000584	active site
869209000585	phosphorylation site [posttranslational modification]
869209000586	intermolecular recognition site; other site
869209000587	dimerization interface [polypeptide binding]; other site
869209000588	ANTAR domain; Region: ANTAR; cl04297
869209000589	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
869209000590	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
869209000591	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
869209000592	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
869209000593	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
869209000594	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
869209000595	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
869209000596	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
869209000597	active site
869209000598	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
869209000599	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412
869209000600	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
869209000601	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
869209000602	HipA N-terminal domain; Region: couple_hipA; TIGR03071
869209000603	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
869209000604	HipA-like N-terminal domain; Region: HipA_N; pfam07805
869209000605	HipA-like C-terminal domain; Region: HipA_C; pfam07804
869209000606	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209000607	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
869209000608	ligand binding site [chemical binding]; other site
869209000609	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
869209000610	dimerization interface [polypeptide binding]; other site
869209000611	Histidine kinase; Region: His_kinase; pfam06580
869209000612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
869209000613	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
869209000614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209000615	active site
869209000616	phosphorylation site [posttranslational modification]
869209000617	intermolecular recognition site; other site
869209000618	dimerization interface [polypeptide binding]; other site
869209000619	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
869209000620	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
869209000621	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
869209000622	MoxR-like ATPases [General function prediction only]; Region: COG0714
869209000623	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209000624	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209000625	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
869209000626	Protein of unknown function DUF58; Region: DUF58; pfam01882
869209000627	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
869209000628	metal ion-dependent adhesion site (MIDAS); other site
869209000629	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
869209000630	metal ion-dependent adhesion site (MIDAS); other site
869209000631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209000632	TPR motif; other site
869209000633	binding surface
869209000634	Smr domain; Region: Smr; cl02619
869209000635	chaperone protein DnaJ; Provisional; Region: PRK14291
869209000636	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
869209000637	HSP70 interaction site [polypeptide binding]; other site
869209000638	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
869209000639	RNA/DNA hybrid binding site [nucleotide binding]; other site
869209000640	active site
869209000641	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
869209000642	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
869209000643	HflX subfamily.  A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily.  The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878
869209000644	G1 box; other site
869209000645	GTP/Mg2+ binding site [chemical binding]; other site
869209000646	Switch I region; other site
869209000647	G2 box; other site
869209000648	G3 box; other site
869209000649	Switch II region; other site
869209000650	G4 box; other site
869209000651	G5 box; other site
869209000652	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
869209000653	active site
869209000654	Peptidase family U32; Region: Peptidase_U32; cl03113
869209000655	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125
869209000656	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125
869209000657	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125
869209000658	Peptidase family M23; Region: Peptidase_M23; pfam01551
869209000659	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125
869209000660	NlpC/P60 family; Region: NLPC_P60; cl11438
869209000661	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
869209000662	N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312
869209000663	THF binding site; other site
869209000664	C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311
869209000665	substrate binding site [chemical binding]; other site
869209000666	THF binding site; other site
869209000667	zinc-binding site [ion binding]; other site
869209000668	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
869209000669	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
869209000670	dimer interface [polypeptide binding]; other site
869209000671	active site
869209000672	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
869209000673	catalytic residues [active]
869209000674	substrate binding site [chemical binding]; other site
869209000675	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
869209000676	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
869209000677	putative catalytic cysteine [active]
869209000678	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK09616
869209000679	B3/4 domain; Region: B3_4; cl11458
869209000680	tRNA synthetase B5 domain; Region: B5; cl08394
869209000681	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
869209000682	dimer interface [polypeptide binding]; other site
869209000683	motif 1; other site
869209000684	motif 3; other site
869209000685	motif 2; other site
869209000686	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human tyrosyl-; Region: tRNA_bindingDomain; cd02153
869209000687	putative tRNA-binding site [nucleotide binding]; other site
869209000688	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
869209000689	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
869209000690	Phage protein D [General function prediction only]; Region: COG3500; cl12180
869209000691	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
869209000692	Phage protein D [General function prediction only]; Region: COG3500; cl12180
869209000693	Phage protein D [General function prediction only]; Region: COG3500; cl12180
869209000694	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
869209000695	Protein of unknown function (DUF3289); Region: DUF3289; cl11840
869209000696	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
869209000697	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
869209000698	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
869209000699	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
869209000700	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
869209000701	dimer interface [polypeptide binding]; other site
869209000702	ssDNA binding site [nucleotide binding]; other site
869209000703	tetramer (dimer of dimers) interface [polypeptide binding]; other site
869209000704	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
869209000705	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
869209000706	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
869209000707	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
869209000708	Adenylsuccinate lyase (ASL)_like; Region: Adenylsuccinate_lyase_like; cd01595
869209000709	tetramer interface [polypeptide binding]; other site
869209000710	active site
869209000711	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
869209000712	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
869209000713	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209000714	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
869209000715	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209000716	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
869209000717	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
869209000718	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
869209000719	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
869209000720	UvrD/REP helicase; Region: UvrD-helicase; cl14126
869209000721	UvrD/REP helicase; Region: UvrD-helicase; cl14126
869209000722	ApbE family; Region: ApbE; cl00643
869209000723	Sodium:neurotransmitter symporter family; Region: SNF; cl11976
869209000724	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cl00257
869209000725	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209000726	non-specific DNA binding site [nucleotide binding]; other site
869209000727	salt bridge; other site
869209000728	sequence-specific DNA binding site [nucleotide binding]; other site
869209000729	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
869209000730	putative active site [active]
869209000731	catalytic site [active]
869209000732	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869209000733	ATP binding site [chemical binding]; other site
869209000734	putative Mg++ binding site [ion binding]; other site
869209000735	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869209000736	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
869209000737	nucleotide binding region [chemical binding]; other site
869209000738	ATP-binding site [chemical binding]; other site
869209000739	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209000740	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
869209000741	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
869209000742	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209000743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209000744	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
869209000745	multiple promoter invertase; Provisional; Region: mpi; PRK13413
869209000746	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
869209000747	catalytic residues [active]
869209000748	catalytic nucleophile [active]
869209000749	Presynaptic Site I dimer interface [polypeptide binding]; other site
869209000750	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
869209000751	Synaptic Flat tetramer interface [polypeptide binding]; other site
869209000752	Synaptic Site I dimer interface [polypeptide binding]; other site
869209000753	DNA binding site [nucleotide binding]
869209000754	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
869209000755	DNA-binding interface [nucleotide binding]; DNA binding site
869209000756	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714
869209000757	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
869209000758	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209000759	putative DNA binding helix; other site
869209000760	metal binding site 2 [ion binding]; metal-binding site
869209000761	metal binding site 1 [ion binding]; metal-binding site
869209000762	dimer interface [polypeptide binding]; other site
869209000763	structural Zn2+ binding site [ion binding]; other site
869209000764	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
869209000765	intersubunit interface [polypeptide binding]; other site
869209000766	YodA lipocalin-like domain; Region: YodA; cl01365
869209000767	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
869209000768	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
869209000769	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
869209000770	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235
869209000771	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869209000772	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
869209000773	metal ion-dependent adhesion site (MIDAS); other site
869209000774	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
869209000775	Catalytic domain of Protein Kinases; Region: PKc; cd00180
869209000776	active site
869209000777	ATP binding site [chemical binding]; other site
869209000778	substrate binding site [chemical binding]; other site
869209000779	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
869209000780	substrate binding site [chemical binding]; other site
869209000781	activation loop (A-loop); other site
869209000782	activation loop (A-loop); other site
869209000783	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784
869209000784	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
869209000785	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
869209000786	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869209000787	Coenzyme A binding pocket [chemical binding]; other site
869209000788	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_1; cd02906
869209000789	putative ADP-ribose binding site [chemical binding]; other site
869209000790	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
869209000791	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209000792	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
869209000793	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713
869209000794	active site
869209000795	dimer interface [polypeptide binding]; other site
869209000796	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
869209000797	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808
869209000798	active site
869209000799	FMN binding site [chemical binding]; other site
869209000800	substrate binding site [chemical binding]; other site
869209000801	3Fe-4S cluster binding site [ion binding]; other site
869209000802	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
869209000803	domain interface; other site
869209000804	NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910
869209000805	6-phosphofructokinase; Provisional; Region: PRK03202
869209000806	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204
869209000807	active site
869209000808	ADP/pyrophosphate binding site [chemical binding]; other site
869209000809	dimerization interface [polypeptide binding]; other site
869209000810	allosteric effector site; other site
869209000811	fructose-1,6-bisphosphate binding site; other site
869209000812	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
869209000813	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
869209000814	phosphate binding site [ion binding]; other site
869209000815	Predicted membrane protein [Function unknown]; Region: COG4684
869209000816	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
869209000817	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
869209000818	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
869209000819	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
869209000820	active site
869209000821	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209000822	Cache domain; Region: Cache_1; pfam02743
869209000823	Sporulation and spore germination; Region: Germane; cl11253
869209000824	prolyl-tRNA synthetase; Provisional; Region: PRK09194
869209000825	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
869209000826	motif 1; other site
869209000827	dimer interface [polypeptide binding]; other site
869209000828	active site
869209000829	motif 2; other site
869209000830	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334
869209000831	putative deacylase active site [active]
869209000832	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
869209000833	active site
869209000834	motif 3; other site
869209000835	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861
869209000836	anticodon binding site; other site
869209000837	Flagellar protein FliS; Region: FliS; cl00654
869209000838	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
869209000839	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
869209000840	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
869209000841	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
869209000842	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
869209000843	anchoring element; other site
869209000844	dimer interface [polypeptide binding]; other site
869209000845	ATP binding site [chemical binding]; other site
869209000846	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both...; Region: TOPRIM_TopoIIA_like; cd01030
869209000847	active site
869209000848	putative metal-binding site [ion binding]; other site
869209000849	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
869209000850	DNA topoisomerase IV subunit A; Provisional; Region: PRK09631
869209000851	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cl00148
869209000852	CAP-like domain; other site
869209000853	Active site [active]
869209000854	primary dimer interface [polypeptide binding]; other site
869209000855	Uncharacterized conserved protein [Function unknown]; Region: COG1739
869209000856	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
869209000857	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
869209000858	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998
869209000859	Ligand Binding Site [chemical binding]; other site
869209000860	Peptidase family M23; Region: Peptidase_M23; pfam01551
869209000861	Virulence protein [General function prediction only]; Region: COG3943
869209000862	Fic/DOC family; Region: Fic; cl00960
869209000863	glycyl-tRNA synthetase; Provisional; Region: PRK04173
869209000864	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
869209000865	motif 1; other site
869209000866	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774
869209000867	active site
869209000868	motif 2; other site
869209000869	motif 3; other site
869209000870	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
869209000871	anticodon binding site; other site
869209000872	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
869209000873	active site
869209000874	catalytic tetrad [active]
869209000875	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
869209000876	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
869209000877	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
869209000878	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
869209000879	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
869209000880	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
869209000881	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
869209000882	Catalytic site [active]
869209000883	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
869209000884	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
869209000885	putative peptidoglycan binding site; other site
869209000886	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
869209000887	Peptidase family M23; Region: Peptidase_M23; pfam01551
869209000888	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
869209000889	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
869209000890	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
869209000891	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
869209000892	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
869209000893	putative valine binding site [chemical binding]; other site
869209000894	dimer interface [polypeptide binding]; other site
869209000895	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
869209000896	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
869209000897	NeuB family; Region: NeuB; cl00496
869209000898	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
869209000899	Prephenate dehydratase; Region: PDT; pfam00800
869209000900	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
869209000901	putative L-Phe binding site [chemical binding]; other site
869209000902	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
869209000903	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
869209000904	nucleotide binding site [chemical binding]; other site
869209000905	substrate binding site [chemical binding]; other site
869209000906	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
869209000907	dimer interface [polypeptide binding]; other site
869209000908	putative threonine allosteric regulatory site; other site
869209000909	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
869209000910	putative threonine allosteric regulatory site; other site
869209000911	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209000912	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
869209000913	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
869209000914	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
869209000915	active site
869209000916	metal binding site [ion binding]; metal-binding site
869209000917	RF-1 domain; Region: RF-1; cl02875
869209000918	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
869209000919	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209000920	Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774
869209000921	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
869209000922	dihydrodipicolinate synthase; Region: dapA; TIGR00674
869209000923	dimer interface [polypeptide binding]; other site
869209000924	active site
869209000925	catalytic residue [active]
869209000926	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
869209000927	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
869209000928	DNA binding residues [nucleotide binding]
869209000929	dimerization interface [polypeptide binding]; other site
869209000930	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
869209000931	Tetramer interface [polypeptide binding]; other site
869209000932	Active site [active]
869209000933	FMN-binding site [chemical binding]; other site
869209000934	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
869209000935	Beta-lactamase; Region: Beta-lactamase; cl01009
869209000936	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
869209000937	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
869209000938	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
869209000939	methionine aminopeptidase; Reviewed; Region: PRK07281
869209000940	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
869209000941	active site
869209000942	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
869209000943	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
869209000944	HSP70 interaction site [polypeptide binding]; other site
869209000945	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
869209000946	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
869209000947	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
869209000948	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
869209000949	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
869209000950	GatB domain; Region: GatB_Yqey; cl11497
869209000951	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
869209000952	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
869209000953	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
869209000954	Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915
869209000955	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
869209000956	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
869209000957	Cupin domain; Region: Cupin_2; cl09118
869209000958	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
869209000959	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
869209000960	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
869209000961	active site
869209000962	phosphorylation site [posttranslational modification]
869209000963	Acyl transferase domain; Region: Acyl_transf_1; cl08282
869209000964	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
869209000965	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
869209000966	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
869209000967	NAD(P) binding site [chemical binding]; other site
869209000968	homotetramer interface [polypeptide binding]; other site
869209000969	homodimer interface [polypeptide binding]; other site
869209000970	active site
869209000971	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
869209000972	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
869209000973	dimer interface [polypeptide binding]; other site
869209000974	active site
869209000975	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
869209000976	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
869209000977	active site
869209000978	multimer interface [polypeptide binding]; other site
869209000979	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
869209000980	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209000981	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
869209000982	signal recognition particle protein; Provisional; Region: PRK10867
869209000983	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
869209000984	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
869209000985	P loop; other site
869209000986	GTP binding site [chemical binding]; other site
869209000987	Signal peptide binding domain; Region: SRP_SPB; pfam02978
869209000988	E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies.  These domains are associated with different types of catalytic domains at  either the N-terminal or C-terminal end; Region: E_set; cl09101
869209000989	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209000990	binding surface
869209000991	TPR motif; other site
869209000992	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
869209000993	Predicted secreted protein (DUF2259); Region: DUF2259; cl02309
869209000994	aspartate aminotransferase; Provisional; Region: PRK07681
869209000995	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
869209000996	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869209000997	homodimer interface [polypeptide binding]; other site
869209000998	catalytic residue [active]
869209000999	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
869209001000	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
869209001001	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869209001002	homodimer interface [polypeptide binding]; other site
869209001003	catalytic residue [active]
869209001004	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
869209001005	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
869209001006	active site
869209001007	metal binding site [ion binding]; metal-binding site
869209001008	pullulanase, type I; Region: pulA_typeI; TIGR02104
869209001009	E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies.  These domains are associated with different types of catalytic domains at  either the N-terminal or C-terminal end; Region: E_set; cl09101
869209001010	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
869209001011	Viral methyltransferase C-terminal; Region: Vmethyltransf_C; pfam08456
869209001012	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869209001013	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209001014	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209001015	Curli production assembly/transport component CsgG; Region: CsgG; cl00639
869209001016	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
869209001017	heat shock protein 90; Provisional; Region: PRK05218
869209001018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
869209001019	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
869209001020	synthetase active site [active]
869209001021	NTP binding site [chemical binding]; other site
869209001022	metal binding site [ion binding]; metal-binding site
869209001023	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209001024	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
869209001025	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
869209001026	argininosuccinate lyase; Provisional; Region: PRK00855
869209001027	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
869209001028	active sites [active]
869209001029	tetramer interface [polypeptide binding]; other site
869209001030	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
869209001031	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
869209001032	substrate binding pocket [chemical binding]; other site
869209001033	membrane-bound complex binding site; other site
869209001034	hinge residues; other site
869209001035	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
869209001036	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209001037	dimer interface [polypeptide binding]; other site
869209001038	conserved gate region; other site
869209001039	putative PBP binding loops; other site
869209001040	ABC-ATPase subunit interface; other site
869209001041	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
869209001042	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262
869209001043	Walker A/P-loop; other site
869209001044	ATP binding site [chemical binding]; other site
869209001045	Q-loop/lid; other site
869209001046	ABC transporter signature motif; other site
869209001047	Walker B; other site
869209001048	D-loop; other site
869209001049	H-loop/switch region; other site
869209001050	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
869209001051	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
869209001052	DRTGG domain; Region: DRTGG; cl12147
869209001053	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
869209001054	DHH family; Region: DHH; pfam01368
869209001055	DHHA2 domain; Region: DHHA2; pfam02833
869209001056	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
869209001057	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
869209001058	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209001059	Walker A/P-loop; other site
869209001060	ATP binding site [chemical binding]; other site
869209001061	Q-loop/lid; other site
869209001062	ABC transporter signature motif; other site
869209001063	Walker B; other site
869209001064	D-loop; other site
869209001065	H-loop/switch region; other site
869209001066	ABC-2 type transporter; Region: ABC2_membrane; cl11417
869209001067	gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521
869209001068	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
869209001069	gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521
869209001070	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
869209001071	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
869209001072	PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553
869209001073	active site
869209001074	uracil binding [chemical binding]; other site
869209001075	DNA polymerase I; Provisional; Region: PRK05755
869209001076	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
869209001077	active site
869209001078	metal binding site 1 [ion binding]; metal-binding site
869209001079	putative 5' ssDNA interaction site; other site
869209001080	metal binding site 3; metal-binding site
869209001081	metal binding site 2 [ion binding]; metal-binding site
869209001082	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
869209001083	putative DNA binding site [nucleotide binding]; other site
869209001084	putative metal binding site [ion binding]; other site
869209001085	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
869209001086	active site
869209001087	catalytic site [active]
869209001088	substrate binding site [chemical binding]; other site
869209001089	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
869209001090	active site
869209001091	DNA binding site [nucleotide binding]
869209001092	catalytic site [active]
869209001093	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
869209001094	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
869209001095	CoA-binding site [chemical binding]; other site
869209001096	ATP-binding [chemical binding]; other site
869209001097	Sporulation related domain; Region: SPOR; cl10051
869209001098	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002
869209001099	putative deacylase active site [active]
869209001100	C subunit; Region: rnfC; TIGR01945
869209001101	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404
869209001102	lipoyl-biotinyl attachment site [posttranslational modification]; other site
869209001103	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
869209001104	SLBB domain; Region: SLBB; pfam10531
869209001105	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
869209001106	RnfE family; Region: NQR2_RnfD_RnfE; cl00779
869209001107	FMN-binding domain; Region: FMN_bind; cl01081
869209001108	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
869209001109	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
869209001110	ferredoxin; Validated; Region: PRK07118
869209001111	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
869209001112	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
869209001113	Sulfate transporter family; Region: Sulfate_transp; cl00967
869209001114	Permease family; Region: Xan_ur_permease; pfam00860
869209001115	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
869209001116	alanyl-tRNA synthetase; Provisional; Region: PRK01584
869209001117	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673
869209001118	motif 1; other site
869209001119	active site
869209001120	motif 2; other site
869209001121	motif 3; other site
869209001122	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
869209001123	SurA N-terminal domain; Region: SurA_N; pfam09312
869209001124	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223
869209001125	putative RNA binding site [nucleotide binding]; other site
869209001126	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320
869209001127	oligomerisation interface [polypeptide binding]; other site
869209001128	mobile loop; other site
869209001129	roof hairpin; other site
869209001130	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
869209001131	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
869209001132	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
869209001133	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
869209001134	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
869209001135	DNA binding residues [nucleotide binding]
869209001136	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
869209001137	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488
869209001138	ssDNA binding site; other site
869209001139	generic binding surface II; other site
869209001140	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869209001141	ATP binding site [chemical binding]; other site
869209001142	putative Mg++ binding site [ion binding]; other site
869209001143	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869209001144	nucleotide binding region [chemical binding]; other site
869209001145	ATP-binding site [chemical binding]; other site
869209001146	YGGT family; Region: YGGT; cl00508
869209001147	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
869209001148	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
869209001149	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
869209001150	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
869209001151	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485
869209001152	generic binding surface II; other site
869209001153	generic binding surface I; other site
869209001154	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
869209001155	dimerization interface [polypeptide binding]; other site
869209001156	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
869209001157	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209001158	Integrase core domain; Region: rve; cl01316
869209001159	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
869209001160	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
869209001161	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
869209001162	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
869209001163	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
869209001164	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
869209001165	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
869209001166	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
869209001167	UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087
869209001168	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
869209001169	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
869209001170	ATP binding site [chemical binding]; other site
869209001171	active site
869209001172	substrate binding site [chemical binding]; other site
869209001173	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
869209001174	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
869209001175	4-alpha-glucanotransferase; Provisional; Region: PLN03236
869209001176	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
869209001177	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
869209001178	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
869209001179	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
869209001180	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342
869209001181	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
869209001182	catalytic residue [active]
869209001183	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
869209001184	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
869209001185	putative active site [active]
869209001186	oxyanion strand; other site
869209001187	catalytic triad [active]
869209001188	Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107
869209001189	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731
869209001190	substrate binding site [chemical binding]; other site
869209001191	glutamase interaction surface [polypeptide binding]; other site
869209001192	pyruvate kinase; Provisional; Region: PRK06354
869209001193	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
869209001194	domain interfaces; other site
869209001195	active site
869209001196	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
869209001197	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
869209001198	active site
869209001199	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
869209001200	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209001201	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
869209001202	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
869209001203	metal ion-dependent adhesion site (MIDAS); other site
869209001204	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
869209001205	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209001206	Cupin domain; Region: Cupin_2; cl09118
869209001207	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
869209001208	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
869209001209	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
869209001210	CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083
869209001211	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
869209001212	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
869209001213	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
869209001214	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
869209001215	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
869209001216	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
869209001217	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
869209001218	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
869209001219	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
869209001220	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
869209001221	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
869209001222	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
869209001223	HsdM N-terminal domain; Region: HsdM_N; pfam12161
869209001224	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209001225	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209001226	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869209001227	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
869209001228	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869209001229	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694
869209001230	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
869209001231	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
869209001232	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869209001233	ATP binding site [chemical binding]; other site
869209001234	putative Mg++ binding site [ion binding]; other site
869209001235	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
869209001236	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
869209001237	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
869209001238	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209001239	subunit; Region: OAD_beta; cl00816
869209001240	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209001241	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
869209001242	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209001243	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
869209001244	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
869209001245	cofactor binding site; other site
869209001246	DNA binding site [nucleotide binding]
869209001247	substrate interaction site [chemical binding]; other site
869209001248	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209001249	5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331
869209001250	LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563
869209001251	putative hydratase; Provisional; Region: PRK11413
869209001252	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
869209001253	substrate binding site [chemical binding]; other site
869209001254	ligand binding site [chemical binding]; other site
869209001255	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
869209001256	substrate binding site [chemical binding]; other site
869209001257	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
869209001258	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209001259	cofactor binding site; other site
869209001260	DNA binding site [nucleotide binding]
869209001261	substrate interaction site [chemical binding]; other site
869209001262	ICEA Protein; Region: ICEA; pfam05315
869209001263	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209001264	non-specific DNA binding site [nucleotide binding]; other site
869209001265	salt bridge; other site
869209001266	sequence-specific DNA binding site [nucleotide binding]; other site
869209001267	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
869209001268	Histidine kinase; Region: HisKA_3; pfam07730
869209001269	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869209001270	ATP binding site [chemical binding]; other site
869209001271	Mg2+ binding site [ion binding]; other site
869209001272	G-X-G motif; other site
869209001273	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
869209001274	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209001275	active site
869209001276	phosphorylation site [posttranslational modification]
869209001277	intermolecular recognition site; other site
869209001278	dimerization interface [polypeptide binding]; other site
869209001279	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
869209001280	DNA binding residues [nucleotide binding]
869209001281	dimerization interface [polypeptide binding]; other site
869209001282	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
869209001283	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
869209001284	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209001285	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
869209001286	active site
869209001287	nucleotide binding site [chemical binding]; other site
869209001288	HIGH motif; other site
869209001289	KMSKS motif; other site
869209001290	LicD family; Region: LicD; cl01378
869209001291	MatE; Region: MatE; cl10513
869209001292	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
869209001293	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
869209001294	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
869209001295	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
869209001296	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
869209001297	Probable Catalytic site [active]
869209001298	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
869209001299	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
869209001300	active site
869209001301	Protein of unknown function DUF262; Region: DUF262; cl14890
869209001302	putative transposase OrfB; Reviewed; Region: PHA02517
869209001303	Integrase core domain; Region: rve; cl01316
869209001304	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209001305	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
869209001306	DEAD-like helicases superfamily; Region: DEXDc; smart00487
869209001307	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869209001308	ATP binding site [chemical binding]; other site
869209001309	putative Mg++ binding site [ion binding]; other site
869209001310	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209001311	C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126
869209001312	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514
869209001313	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209001314	non-specific DNA binding site [nucleotide binding]; other site
869209001315	salt bridge; other site
869209001316	sequence-specific DNA binding site [nucleotide binding]; other site
869209001317	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
869209001318	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
869209001319	Radical SAM; Region: Elp3; smart00729
869209001320	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
869209001321	FeS/SAM binding site; other site
869209001322	CrcB-like protein; Region: CRCB; cl09114
869209001323	MgtE intracellular N domain; Region: MgtE_N; cl15244
869209001324	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
869209001325	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
869209001326	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209001327	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
869209001328	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
869209001329	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869209001330	ATP binding site [chemical binding]; other site
869209001331	putative Mg++ binding site [ion binding]; other site
869209001332	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
869209001333	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869209001334	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
869209001335	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209001336	Fic/DOC family; Region: Fic; cl00960
869209001337	Fic/DOC family; Region: Fic; cl00960
869209001338	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209001339	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869209001340	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
869209001341	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869209001342	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
869209001343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
869209001344	Virulence protein [General function prediction only]; Region: COG3943
869209001345	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
869209001346	MatE; Region: MatE; cl10513
869209001347	MatE; Region: MatE; cl10513
869209001348	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342
869209001349	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
869209001350	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
869209001351	catalytic residue [active]
869209001352	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
869209001353	FMN binding site [chemical binding]; other site
869209001354	dimer interface [polypeptide binding]; other site
869209001355	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
869209001356	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
869209001357	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
869209001358	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
869209001359	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
869209001360	putative active site [active]
869209001361	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
869209001362	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
869209001363	HIGH motif; other site
869209001364	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
869209001365	active site
869209001366	KMSKS motif; other site
869209001367	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
869209001368	tRNA binding surface [nucleotide binding]; other site
869209001369	Cation efflux family; Region: Cation_efflux; cl00316
869209001370	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
869209001371	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
869209001372	FMN binding site [chemical binding]; other site
869209001373	active site
869209001374	catalytic residues [active]
869209001375	substrate binding site [chemical binding]; other site
869209001376	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920
869209001377	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
869209001378	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
869209001379	Mg++ binding site [ion binding]; other site
869209001380	putative catalytic motif [active]
869209001381	substrate binding site [chemical binding]; other site
869209001382	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
869209001383	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
869209001384	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
869209001385	active site
869209001386	HIGH motif; other site
869209001387	KMSK motif region; other site
869209001388	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
869209001389	tRNA binding surface [nucleotide binding]; other site
869209001390	anticodon binding site; other site
869209001391	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the...; Region: citrate_synt_like_1_2; cd06113
869209001392	dimer interface [polypeptide binding]; other site
869209001393	active site
869209001394	citrylCoA binding site [chemical binding]; other site
869209001395	Citrate synthase; Region: Citrate_synt; pfam00285
869209001396	oxalacetate/citrate binding site [chemical binding]; other site
869209001397	coenzyme A binding site [chemical binding]; other site
869209001398	catalytic triad [active]
869209001399	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
869209001400	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446
869209001401	dimer interface [polypeptide binding]; other site
869209001402	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
869209001403	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
869209001404	chaperone protein DnaJ; Provisional; Region: PRK10767
869209001405	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
869209001406	HSP70 interaction site [polypeptide binding]; other site
869209001407	DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908
869209001408	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
869209001409	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
869209001410	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
869209001411	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
869209001412	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
869209001413	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
869209001414	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
869209001415	anti sigma factor interaction site; other site
869209001416	regulatory phosphorylation site [posttranslational modification]; other site
869209001417	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
869209001418	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
869209001419	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
869209001420	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
869209001421	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
869209001422	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
869209001423	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
869209001424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209001425	dimer interface [polypeptide binding]; other site
869209001426	ABC-ATPase subunit interface; other site
869209001427	putative PBP binding loops; other site
869209001428	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
869209001429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209001430	dimer interface [polypeptide binding]; other site
869209001431	conserved gate region; other site
869209001432	putative PBP binding loops; other site
869209001433	ABC-ATPase subunit interface; other site
869209001434	FtsH Extracellular; Region: FtsH_ext; pfam06480
869209001435	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
869209001436	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209001437	Walker A motif; other site
869209001438	ATP binding site [chemical binding]; other site
869209001439	Walker B motif; other site
869209001440	arginine finger; other site
869209001441	Peptidase family M41; Region: Peptidase_M41; pfam01434
869209001442	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
869209001443	DbpA RNA binding domain; Region: DbpA; pfam03880
869209001444	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869209001445	Coenzyme A binding pocket [chemical binding]; other site
869209001446	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
869209001447	oligomer interface [polypeptide binding]; other site
869209001448	active site residues [active]
869209001449	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
869209001450	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
869209001451	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
869209001452	putative active site [active]
869209001453	catalytic residue [active]
869209001454	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
869209001455	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
869209001456	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
869209001457	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
869209001458	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
869209001459	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
869209001460	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
869209001461	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209001462	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
869209001463	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
869209001464	UvrD/REP helicase; Region: UvrD-helicase; cl14126
869209001465	UvrD/REP helicase; Region: UvrD-helicase; cl14126
869209001466	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
869209001467	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
869209001468	active site
869209001469	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
869209001470	DTW domain; Region: DTW; cl01221
869209001471	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
869209001472	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
869209001473	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
869209001474	active site
869209001475	substrate binding site [chemical binding]; other site
869209001476	metal binding site [ion binding]; metal-binding site
869209001477	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
869209001478	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
869209001479	putative NADH binding site [chemical binding]; other site
869209001480	putative active site [active]
869209001481	nudix motif; other site
869209001482	putative metal binding site [ion binding]; other site
869209001483	Domain of unknown function (DUF955); Region: DUF955; cl01076
869209001484	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209001485	non-specific DNA binding site [nucleotide binding]; other site
869209001486	salt bridge; other site
869209001487	sequence-specific DNA binding site [nucleotide binding]; other site
869209001488	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209001489	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209001490	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209001491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209001492	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
869209001493	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209001494	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
869209001495	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
869209001496	integron integrase; Region: integrase_gron; TIGR02249
869209001497	DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and a secondary target called the attC (or 59-base element)...; Region: INT_IntI; cd01193
869209001498	Int/Topo IB signature motif; other site
869209001499	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
869209001500	nudix motif; other site
869209001501	Protein of unknown function (DUF497); Region: DUF497; cl01108
869209001502	TM2 domain; Region: TM2; cl00984
869209001503	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
869209001504	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
869209001505	putative active site [active]
869209001506	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cl00257
869209001507	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209001508	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408
869209001509	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
869209001510	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408
869209001511	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209001512	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694
869209001513	Transposase; Region: DEDD_Tnp_IS110; pfam01548
869209001514	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
869209001515	TM2 domain; Region: TM2; cl00984
869209001516	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
869209001517	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
869209001518	putative active site [active]
869209001519	Nuclease-related domain; Region: NERD; pfam08378
869209001520	DNA topoisomerase I; Validated; Region: PRK07219
869209001521	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
869209001522	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869209001523	Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792
869209001524	Acyltransferase family; Region: Acyl_transf_3; pfam01757
869209001525	Acyltransferase family; Region: Acyl_transf_3; pfam01757
869209001526	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
869209001527	Transposase; Region: DEDD_Tnp_IS110; pfam01548
869209001528	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
869209001529	SinI restriction endonuclease; Region: RE_SinI; pfam09570
869209001530	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
869209001531	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
869209001532	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
869209001533	cofactor binding site; other site
869209001534	DNA binding site [nucleotide binding]
869209001535	substrate interaction site [chemical binding]; other site
869209001536	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
869209001537	Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792
869209001538	Acyltransferase family; Region: Acyl_transf_3; pfam01757
869209001539	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
869209001540	putative homodimer interface [polypeptide binding]; other site
869209001541	putative active site [active]
869209001542	catalytic site [active]
869209001543	DNA cytosine methylase; Provisional; Region: PRK10458
869209001544	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
869209001545	cofactor binding site; other site
869209001546	DNA binding site [nucleotide binding]
869209001547	substrate interaction site [chemical binding]; other site
869209001548	DNA binding domains of BfiI, EcoRII and plant B3 proteins; Region: BfiI_C_EcoRII_N_B3; cl15242
869209001549	DNA binding site [nucleotide binding]
869209001550	EcoRII C terminal; Region: EcoRII-C; pfam09019
869209001551	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
869209001552	Transposase; Region: DEDD_Tnp_IS110; pfam01548
869209001553	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
869209001554	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
869209001555	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
869209001556	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209001557	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
869209001558	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209001559	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
869209001560	cofactor binding site; other site
869209001561	DNA binding site [nucleotide binding]
869209001562	substrate interaction site [chemical binding]; other site
869209001563	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209001564	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
869209001565	Transposase; Region: DEDD_Tnp_IS110; pfam01548
869209001566	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
869209001567	Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792
869209001568	Acyltransferase family; Region: Acyl_transf_3; pfam01757
869209001569	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
869209001570	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
869209001571	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
869209001572	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
869209001573	SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877
869209001574	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
869209001575	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
869209001576	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
869209001577	Transposase; Region: DEDD_Tnp_IS110; pfam01548
869209001578	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
869209001579	TM2 domain; Region: TM2; cl00984
869209001580	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
869209001581	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
869209001582	putative active site [active]
869209001583	SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877
869209001584	PemK-like protein; Region: PemK; cl00995
869209001585	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
869209001586	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
869209001587	putative active site [active]
869209001588	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
869209001589	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
869209001590	FeS/SAM binding site; other site
869209001591	radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085
869209001592	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209001593	Walker A/P-loop; other site
869209001594	ATP binding site [chemical binding]; other site
869209001595	Q-loop/lid; other site
869209001596	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209001597	ABC transporter signature motif; other site
869209001598	Walker B; other site
869209001599	D-loop; other site
869209001600	H-loop/switch region; other site
869209001601	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209001602	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209001603	Walker A/P-loop; other site
869209001604	Walker A/P-loop; other site
869209001605	ATP binding site [chemical binding]; other site
869209001606	ATP binding site [chemical binding]; other site
869209001607	Q-loop/lid; other site
869209001608	ABC transporter signature motif; other site
869209001609	Walker B; other site
869209001610	D-loop; other site
869209001611	H-loop/switch region; other site
869209001612	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
869209001613	Transposase; Region: DEDD_Tnp_IS110; pfam01548
869209001614	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
869209001615	TM2 domain; Region: TM2; cl00984
869209001616	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
869209001617	oligomeric interface; other site
869209001618	putative active site [active]
869209001619	homodimer interface [polypeptide binding]; other site
869209001620	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869209001621	Coenzyme A binding pocket [chemical binding]; other site
869209001622	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
869209001623	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
869209001624	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209001625	non-specific DNA binding site [nucleotide binding]; other site
869209001626	salt bridge; other site
869209001627	sequence-specific DNA binding site [nucleotide binding]; other site
869209001628	Protein of unknown function (DUF541); Region: SIMPL; cl01077
869209001629	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
869209001630	Transposase; Region: DEDD_Tnp_IS110; pfam01548
869209001631	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
869209001632	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
869209001633	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
869209001634	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209001635	Protein of unknown function DUF262; Region: DUF262; cl14890
869209001636	Protein of unknown function DUF262; Region: DUF262; cl14890
869209001637	Protein of unknown function DUF262; Region: DUF262; cl14890
869209001638	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
869209001639	Transposase; Region: DEDD_Tnp_IS110; pfam01548
869209001640	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
869209001641	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209001642	non-specific DNA binding site [nucleotide binding]; other site
869209001643	salt bridge; other site
869209001644	sequence-specific DNA binding site [nucleotide binding]; other site
869209001645	ketol-acid reductoisomerase; Validated; Region: PRK05225
869209001646	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209001647	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
869209001648	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
869209001649	Sodium:solute symporter family; Region: SSF; cl00456
869209001650	bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427
869209001651	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
869209001652	dimer interface [polypeptide binding]; other site
869209001653	substrate binding site [chemical binding]; other site
869209001654	ATP binding site [chemical binding]; other site
869209001655	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564
869209001656	thiamine phosphate binding site [chemical binding]; other site
869209001657	active site
869209001658	pyrophosphate binding site [ion binding]; other site
869209001659	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
869209001660	substrate binding site [chemical binding]; other site
869209001661	multimerization interface [polypeptide binding]; other site
869209001662	ATP binding site [chemical binding]; other site
869209001663	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
869209001664	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209001665	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
869209001666	hypothetical protein; Provisional; Region: PRK06849
869209001667	Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313
869209001668	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
869209001669	FeS/SAM binding site; other site
869209001670	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
869209001671	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
869209001672	nudix motif; other site
869209001673	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
869209001674	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
869209001675	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
869209001676	catalytic residues [active]
869209001677	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209001678	Glucose inhibited division protein A; Region: GIDA; pfam01134
869209001679	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209001680	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973
869209001681	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
869209001682	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
869209001683	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279
869209001684	active site
869209001685	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
869209001686	cyclase homology domain; Region: CHD; cd07302
869209001687	nucleotidyl binding site; other site
869209001688	metal binding site [ion binding]; metal-binding site
869209001689	dimer interface [polypeptide binding]; other site
869209001690	V-type ATP synthase subunit I; Validated; Region: PRK05771
869209001691	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
869209001692	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
869209001693	RNA binding surface [nucleotide binding]; other site
869209001694	PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553
869209001695	active site
869209001696	uracil binding [chemical binding]; other site
869209001697	Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268
869209001698	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
869209001699	Potassium binding sites [ion binding]; other site
869209001700	Cesium cation binding sites [ion binding]; other site
869209001701	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
869209001702	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
869209001703	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
869209001704	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
869209001705	active site
869209001706	catalytic residues [active]
869209001707	metal binding site [ion binding]; metal-binding site
869209001708	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
869209001709	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
869209001710	isocitrate dehydrogenase; Validated; Region: PRK06451
869209001711	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
869209001712	dimer interface [polypeptide binding]; other site
869209001713	phosphorylation site [posttranslational modification]
869209001714	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869209001715	ATP binding site [chemical binding]; other site
869209001716	Mg2+ binding site [ion binding]; other site
869209001717	G-X-G motif; other site
869209001718	Response regulator receiver domain; Region: Response_reg; pfam00072
869209001719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209001720	active site
869209001721	phosphorylation site [posttranslational modification]
869209001722	intermolecular recognition site; other site
869209001723	dimerization interface [polypeptide binding]; other site
869209001724	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
869209001725	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
869209001726	active site
869209001727	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
869209001728	substrate binding site [chemical binding]; other site
869209001729	catalytic residues [active]
869209001730	dimer interface [polypeptide binding]; other site
869209001731	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605
869209001732	hemerythrin-like metal-binding domain; Region: hemeryth_dom; TIGR02481
869209001733	octamerization interface [polypeptide binding]; other site
869209001734	diferric-oxygen binding site [ion binding]; other site
869209001735	FeoA domain; Region: FeoA; cl00838
869209001736	FeoA domain; Region: FeoA; cl00838
869209001737	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
869209001738	Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions.  FeoB has been identified as part of this...; Region: FeoB; cd01879
869209001739	G1 box; other site
869209001740	GTP/Mg2+ binding site [chemical binding]; other site
869209001741	Switch I region; other site
869209001742	G2 box; other site
869209001743	G3 box; other site
869209001744	Switch II region; other site
869209001745	G4 box; other site
869209001746	G5 box; other site
869209001747	Nucleoside recognition; Region: Gate; cl00486
869209001748	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
869209001749	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
869209001750	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
869209001751	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
869209001752	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
869209001753	DNA binding residues [nucleotide binding]
869209001754	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
869209001755	Isoamylase N-terminus domain. Isoamylase (aka glycogen 6-glucanohydrolase) is one of the starch-debranching enzymes that catalyzes the hydrolysis of alpha-1,6-glucosidic linkages specific in alpha-glucans such as amylopectin or glycogen. Isoamylase...; Region: Isoamylase_N_term; cd02852
869209001756	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
869209001757	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
869209001758	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
869209001759	homodimer interface [polypeptide binding]; other site
869209001760	active site pocket [active]
869209001761	EamA-like transporter family; Region: EamA; cl01037
869209001762	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
869209001763	EamA-like transporter family; Region: EamA; cl01037
869209001764	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488
869209001765	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
869209001766	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
869209001767	GIY-YIG motif/motif A; other site
869209001768	active site
869209001769	catalytic site [active]
869209001770	putative DNA binding site [nucleotide binding]; other site
869209001771	metal binding site [ion binding]; metal-binding site
869209001772	UvrB/uvrC motif; Region: UVR; pfam02151
869209001773	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
869209001774	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
869209001775	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209001776	binding surface
869209001777	TPR motif; other site
869209001778	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209001779	binding surface
869209001780	TPR motif; other site
869209001781	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209001782	binding surface
869209001783	TPR motif; other site
869209001784	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
869209001785	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209001786	binding surface
869209001787	TPR motif; other site
869209001788	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209001789	binding surface
869209001790	TPR motif; other site
869209001791	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209001792	binding surface
869209001793	TPR motif; other site
869209001794	AIR carboxylase; Region: AIRC; cl00310
869209001795	amidophosphoribosyltransferase; Provisional; Region: PRK05793
869209001796	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
869209001797	active site
869209001798	tetramer interface [polypeptide binding]; other site
869209001799	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
869209001800	Archaeal ATPase; Region: Arch_ATPase; pfam01637
869209001801	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
869209001802	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cl00257
869209001803	Transposase domain (DUF772); Region: DUF772; cl12084
869209001804	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
869209001805	active site
869209001806	catalytic motif [active]
869209001807	Zn binding site [ion binding]; other site
869209001808	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
869209001809	TM-ABC transporter signature motif; other site
869209001810	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580
869209001811	TM-ABC transporter signature motif; other site
869209001812	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
869209001813	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
869209001814	Walker A/P-loop; other site
869209001815	ATP binding site [chemical binding]; other site
869209001816	Q-loop/lid; other site
869209001817	ABC transporter signature motif; other site
869209001818	Walker B; other site
869209001819	D-loop; other site
869209001820	H-loop/switch region; other site
869209001821	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
869209001822	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
869209001823	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
869209001824	ligand binding site [chemical binding]; other site
869209001825	Integrase core domain; Region: rve; cl01316
869209001826	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
869209001827	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209001828	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
869209001829	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
869209001830	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
869209001831	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209001832	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
869209001833	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196
869209001834	dimerization interface [polypeptide binding]; other site
869209001835	putative ATP binding site [chemical binding]; other site
869209001836	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
869209001837	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
869209001838	active site
869209001839	substrate binding site [chemical binding]; other site
869209001840	cosubstrate binding site; other site
869209001841	catalytic site [active]
869209001842	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
869209001843	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755
869209001844	putative ATP binding site [chemical binding]; other site
869209001845	putative substrate interface [chemical binding]; other site
869209001846	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
869209001847	ligand binding site [chemical binding]; other site
869209001848	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
869209001849	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
869209001850	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209001851	pyruvate carboxylase subunit B; Validated; Region: PRK09282
869209001852	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
869209001853	active site
869209001854	catalytic residues [active]
869209001855	metal binding site [ion binding]; metal-binding site
869209001856	homodimer binding site [polypeptide binding]; other site
869209001857	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
869209001858	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
869209001859	carboxyltransferase (CT) interaction site; other site
869209001860	biotinylation site [posttranslational modification]; other site
869209001861	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850
869209001862	carboxyltransferase (CT) interaction site; other site
869209001863	biotinylation site [posttranslational modification]; other site
869209001864	subunit; Region: OAD_beta; cl00816
869209001865	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
869209001866	Transposase; Region: DEDD_Tnp_IS110; pfam01548
869209001867	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
869209001868	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
869209001869	Protein of unknown function (DUF464); Region: DUF464; cl01080
869209001870	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
869209001871	GTPase CgtA; Reviewed; Region: obgE; PRK12299
869209001872	GTP1/OBG; Region: GTP1_OBG; pfam01018
869209001873	Obg subfamily.  The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation.  Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898
869209001874	G1 box; other site
869209001875	GTP/Mg2+ binding site [chemical binding]; other site
869209001876	Switch I region; other site
869209001877	G2 box; other site
869209001878	G3 box; other site
869209001879	Switch II region; other site
869209001880	G4 box; other site
869209001881	G5 box; other site
869209001882	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
869209001883	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
869209001884	active site
869209001885	(T/H)XGH motif; other site
869209001886	Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713
869209001887	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
869209001888	Zn2+ binding site [ion binding]; other site
869209001889	Mg2+ binding site [ion binding]; other site
869209001890	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
869209001891	Domain of unknown function DUF143; Region: DUF143; cl00519
869209001892	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
869209001893	N-acetyl-D-glucosamine binding site [chemical binding]; other site
869209001894	catalytic residue [active]
869209001895	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
869209001896	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209001897	TPR motif; other site
869209001898	binding surface
869209001899	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
869209001900	Preprotein translocase subunit; Region: YajC; cl00806
869209001901	protein-export membrane protein SecD; Region: secD; TIGR01129
869209001902	Protein export membrane protein; Region: SecD_SecF; cl14618
869209001903	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
869209001904	protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966
869209001905	Protein export membrane protein; Region: SecD_SecF; cl14618
869209001906	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
869209001907	LytB protein; Region: LYTB; cl00507
869209001908	potential frameshift: common BLAST hit: gi|42527533|ref|NP_972631.1| OmpA family protein
869209001909	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
869209001910	Flagellar hook capping protein; Region: FlgD; cl04347
869209001911	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
869209001912	ligand binding site [chemical binding]; other site
869209001913	oligoendopeptidase F; Region: pepF; TIGR00181
869209001914	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
869209001915	active site
869209001916	Zn binding site [ion binding]; other site
869209001917	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
869209001918	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
869209001919	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209001920	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
869209001921	ABC transporter; Region: ABC_tran_2; pfam12848
869209001922	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
869209001923	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
869209001924	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
869209001925	NAD binding site [chemical binding]; other site
869209001926	homodimer interface [polypeptide binding]; other site
869209001927	active site
869209001928	substrate binding site [chemical binding]; other site
869209001929	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650
869209001930	diaminopimelate aminotransferase; Provisional; Region: PRK13983
869209001931	metal binding site [ion binding]; metal-binding site
869209001932	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
869209001933	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869209001934	Coenzyme A binding pocket [chemical binding]; other site
869209001935	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
869209001936	dimer interface [polypeptide binding]; other site
869209001937	phosphorylation site [posttranslational modification]
869209001938	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869209001939	ATP binding site [chemical binding]; other site
869209001940	Mg2+ binding site [ion binding]; other site
869209001941	G-X-G motif; other site
869209001942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209001943	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
869209001944	active site
869209001945	phosphorylation site [posttranslational modification]
869209001946	intermolecular recognition site; other site
869209001947	dimerization interface [polypeptide binding]; other site
869209001948	Response regulator receiver domain; Region: Response_reg; pfam00072
869209001949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209001950	active site
869209001951	phosphorylation site [posttranslational modification]
869209001952	intermolecular recognition site; other site
869209001953	dimerization interface [polypeptide binding]; other site
869209001954	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869209001955	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209001956	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209001957	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
869209001958	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209001959	Walker A motif; other site
869209001960	ATP binding site [chemical binding]; other site
869209001961	Walker B motif; other site
869209001962	arginine finger; other site
869209001963	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
869209001964	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
869209001965	active site
869209001966	catalytic triad [active]
869209001967	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209001968	Domain of unknown function (DUF955); Region: DUF955; cl01076
869209001969	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
869209001970	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
869209001971	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
869209001972	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209001973	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
869209001974	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
869209001975	substrate binding [chemical binding]; other site
869209001976	active site
869209001977	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
869209001978	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
869209001979	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
869209001980	putative substrate binding site [chemical binding]; other site
869209001981	putative ATP binding site [chemical binding]; other site
869209001982	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
869209001983	Ferritin-like domain; Region: Ferritin; pfam00210
869209001984	ferroxidase diiron center [ion binding]; other site
869209001985	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
869209001986	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
869209001987	non-heme iron binding site [ion binding]; other site
869209001988	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
869209001989	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
869209001990	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
869209001991	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
869209001992	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
869209001993	hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512
869209001994	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
869209001995	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
869209001996	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
869209001997	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
869209001998	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
869209001999	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
869209002000	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
869209002001	active site
869209002002	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
869209002003	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_6; cd04955
869209002004	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
869209002005	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209002006	Walker A/P-loop; other site
869209002007	ATP binding site [chemical binding]; other site
869209002008	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
869209002009	Uncharacterized conserved protein [Function unknown]; Region: COG2433
869209002010	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083
869209002011	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
869209002012	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
869209002013	classical (c) SDRs; Region: SDR_c; cd05233
869209002014	NAD(P) binding site [chemical binding]; other site
869209002015	active site
869209002016	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
869209002017	hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512
869209002018	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
869209002019	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
869209002020	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209002021	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152
869209002022	heterotetramer interface [polypeptide binding]; other site
869209002023	active site pocket [active]
869209002024	cleavage site
869209002025	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250
869209002026	feedback inhibition sensing region; other site
869209002027	homohexameric interface [polypeptide binding]; other site
869209002028	nucleotide binding site [chemical binding]; other site
869209002029	N-acetyl-L-glutamate binding site [chemical binding]; other site
869209002030	acetylornithine aminotransferase; Provisional; Region: PRK02627
869209002031	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610
869209002032	inhibitor-cofactor binding pocket; inhibition site
869209002033	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869209002034	catalytic residue [active]
869209002035	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
869209002036	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
869209002037	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
869209002038	ANP binding site [chemical binding]; other site
869209002039	Substrate Binding Site II [chemical binding]; other site
869209002040	Substrate Binding Site I [chemical binding]; other site
869209002041	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
869209002042	substrate binding site [chemical binding]; other site
869209002043	dimer interface [polypeptide binding]; other site
869209002044	catalytic triad [active]
869209002045	Chromate transporter; Region: Chromate_transp; pfam02417
869209002046	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
869209002047	Chromate transporter; Region: Chromate_transp; pfam02417
869209002048	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
869209002049	peptide chain release factor 1; Validated; Region: prfA; PRK00591
869209002050	RF-1 domain; Region: RF-1; cl02875
869209002051	RF-1 domain; Region: RF-1; cl02875
869209002052	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
869209002053	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209002054	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
869209002055	S-adenosylmethionine binding site [chemical binding]; other site
869209002056	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
869209002057	lactaldehyde reductase; Region: lactal_redase; TIGR02638
869209002058	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
869209002059	active site
869209002060	NAD binding site [chemical binding]; other site
869209002061	metal binding site [ion binding]; metal-binding site
869209002062	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
869209002063	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
869209002064	intersubunit interface [polypeptide binding]; other site
869209002065	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
869209002066	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235
869209002067	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
869209002068	ABC-ATPase subunit  interface; other site
869209002069	dimer interface [polypeptide binding]; other site
869209002070	putative PBP binding regions; other site
869209002071	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
869209002072	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
869209002073	motif II; other site
869209002074	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
869209002075	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
869209002076	MutS2 homologs in bacteria and eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280
869209002077	Walker A/P-loop; other site
869209002078	ATP binding site [chemical binding]; other site
869209002079	Q-loop/lid; other site
869209002080	ABC transporter signature motif; other site
869209002081	Walker B; other site
869209002082	D-loop; other site
869209002083	H-loop/switch region; other site
869209002084	Smr domain; Region: Smr; cl02619
869209002085	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
869209002086	Arginine repressor [Transcription]; Region: ArgR; COG1438
869209002087	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
869209002088	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095
869209002089	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
869209002090	active site
869209002091	dimer interface [polypeptide binding]; other site
869209002092	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
869209002093	dimer interface [polypeptide binding]; other site
869209002094	active site
869209002095	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
869209002096	active site
869209002097	Uncharacterised protein family UPF0102; Region: UPF0102; cl00516
869209002098	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017
869209002099	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
869209002100	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
869209002101	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
869209002102	RimM N-terminal domain; Region: RimM; pfam01782
869209002103	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794
869209002104	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
869209002105	galactokinase; Provisional; Region: PRK05322
869209002106	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
869209002107	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
869209002108	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
869209002109	conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319
869209002110	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
869209002111	Zn2+ binding site [ion binding]; other site
869209002112	Mg2+ binding site [ion binding]; other site
869209002113	MBOAT family; Region: MBOAT; cl00738
869209002114	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
869209002115	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
869209002116	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
869209002117	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
869209002118	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
869209002119	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
869209002120	catalytic residue [active]
869209002121	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087; cl07963
869209002122	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
869209002123	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
869209002124	active site
869209002125	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
869209002126	active site
869209002127	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
869209002128	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
869209002129	active site
869209002130	Cupin domain; Region: Cupin_2; cl09118
869209002131	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
869209002132	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
869209002133	inhibitor-cofactor binding pocket; inhibition site
869209002134	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869209002135	catalytic residue [active]
869209002136	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
869209002137	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
869209002138	Ligand binding site [chemical binding]; other site
869209002139	Putative Catalytic site [active]
869209002140	DXD motif; other site
869209002141	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
869209002142	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
869209002143	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
869209002144	Domain of unknown function (DUF1850); Region: DUF1850; cl01950
869209002145	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
869209002146	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
869209002147	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
869209002148	active site
869209002149	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
869209002150	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
869209002151	MatE; Region: MatE; cl10513
869209002152	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
869209002153	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
869209002154	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen...; Region: AdeC; cd01295
869209002155	active site
869209002156	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
869209002157	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
869209002158	Found in ATP-dependent protease La (LON); Region: LON; smart00464
869209002159	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209002160	Walker A motif; other site
869209002161	ATP binding site [chemical binding]; other site
869209002162	Walker B motif; other site
869209002163	arginine finger; other site
869209002164	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
869209002165	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
869209002166	phosphopeptide binding site; other site
869209002167	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
869209002168	active site
869209002169	metal binding site [ion binding]; metal-binding site
869209002170	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
869209002171	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
869209002172	active site
869209002173	ATP binding site [chemical binding]; other site
869209002174	substrate binding site [chemical binding]; other site
869209002175	activation loop (A-loop); other site
869209002176	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
869209002177	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570
869209002178	active site
869209002179	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
869209002180	classical (c) SDRs; Region: SDR_c; cd05233
869209002181	NAD(P) binding site [chemical binding]; other site
869209002182	active site
869209002183	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
869209002184	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209002185	GAF domain; Region: GAF; cl00853
869209002186	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
869209002187	Zn2+ binding site [ion binding]; other site
869209002188	Mg2+ binding site [ion binding]; other site
869209002189	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
869209002190	Cell division protein ZapA; Region: ZapA; cl01146
869209002191	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
869209002192	23S rRNA binding site [nucleotide binding]; other site
869209002193	L21 binding site [polypeptide binding]; other site
869209002194	L13 binding site [polypeptide binding]; other site
869209002195	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
869209002196	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
869209002197	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
869209002198	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
869209002199	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947
869209002200	hypothetical protein; Provisional; Region: PRK08185
869209002201	intersubunit interface [polypeptide binding]; other site
869209002202	active site
869209002203	zinc binding site [ion binding]; other site
869209002204	Na+ binding site [ion binding]; other site
869209002205	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
869209002206	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
869209002207	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200
869209002208	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
869209002209	RuvA N terminal domain; Region: RuvA_N; pfam01330
869209002210	Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966
869209002211	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
869209002212	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209002213	Walker A motif; other site
869209002214	ATP binding site [chemical binding]; other site
869209002215	Walker B motif; other site
869209002216	arginine finger; other site
869209002217	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
869209002218	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
869209002219	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
869209002220	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
869209002221	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
869209002222	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
869209002223	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
869209002224	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
869209002225	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
869209002226	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
869209002227	inhibitor-cofactor binding pocket; inhibition site
869209002228	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869209002229	catalytic residue [active]
869209002230	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209002231	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
869209002232	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
869209002233	NAD(P) binding site [chemical binding]; other site
869209002234	homodimer interface [polypeptide binding]; other site
869209002235	substrate binding site [chemical binding]; other site
869209002236	active site
869209002237	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
869209002238	ATP cone domain; Region: ATP-cone; pfam03477
869209002239	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
869209002240	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
869209002241	putative active site [active]
869209002242	catalytic triad [active]
869209002243	putative dimer interface [polypeptide binding]; other site
869209002244	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
869209002245	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
869209002246	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
869209002247	Survival protein SurE; Region: SurE; cl00448
869209002248	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209002249	binding surface
869209002250	TPR motif; other site
869209002251	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209002252	binding surface
869209002253	TPR motif; other site
869209002254	SdiA-regulated; Region: SdiA-regulated; cl06158
869209002255	putative active site [active]
869209002256	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
869209002257	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
869209002258	metal ion-dependent adhesion site (MIDAS); other site
869209002259	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
869209002260	active site
869209002261	DNA polymerase IV; Validated; Region: PRK02406
869209002262	DNA binding site [nucleotide binding]
869209002263	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209002264	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
869209002265	DNA ligase, NAD-dependent; Region: dnlj; TIGR00575
869209002266	nucleotide binding pocket [chemical binding]; other site
869209002267	K-X-D-G motif; other site
869209002268	catalytic site [active]
869209002269	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
869209002270	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027
869209002271	Dimer interface [polypeptide binding]; other site
869209002272	BRCT sequence motif; other site
869209002273	Peptidase family M23; Region: Peptidase_M23; pfam01551
869209002274	DHH family; Region: DHH; pfam01368
869209002275	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
869209002276	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
869209002277	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
869209002278	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
869209002279	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
869209002280	DNA repair protein RecO; Region: reco; TIGR00613
869209002281	Recombination protein O N terminal; Region: RecO_N; pfam11967
869209002282	Recombination protein O C terminal; Region: RecO_C; pfam02565
869209002283	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869209002284	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209002285	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209002286	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784
869209002287	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
869209002288	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
869209002289	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869209002290	ATP binding site [chemical binding]; other site
869209002291	putative Mg++ binding site [ion binding]; other site
869209002292	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209002293	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
869209002294	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869209002295	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
869209002296	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
869209002297	DNA binding site [nucleotide binding]
869209002298	Int/Topo IB signature motif; other site
869209002299	active site
869209002300	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869209002301	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
869209002302	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
869209002303	DNA binding site [nucleotide binding]
869209002304	Int/Topo IB signature motif; other site
869209002305	active site
869209002306	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869209002307	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869209002308	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
869209002309	Divergent AAA domain; Region: AAA_4; pfam04326
869209002310	HsdM N-terminal domain; Region: HsdM_N; pfam12161
869209002311	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
869209002312	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209002313	RmuC family; Region: RmuC; pfam02646
869209002314	DNA replication protein DnaC; Validated; Region: PRK07952
869209002315	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
869209002316	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869209002317	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869209002318	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209002319	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
869209002320	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
869209002321	DNA binding site [nucleotide binding]
869209002322	Int/Topo IB signature motif; other site
869209002323	active site
869209002324	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780
869209002325	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
869209002326	active site
869209002327	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869209002328	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
869209002329	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869209002330	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
869209002331	HsdM N-terminal domain; Region: HsdM_N; pfam12161
869209002332	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209002333	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
869209002334	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869209002335	ATP binding site [chemical binding]; other site
869209002336	putative Mg++ binding site [ion binding]; other site
869209002337	Domain of unknown function (DUF3559); Region: DUF3559; pfam12082
869209002338	HipA-like C-terminal domain; Region: HipA_C; pfam07804
869209002339	flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396
869209002340	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
869209002341	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
869209002342	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
869209002343	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
869209002344	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
869209002345	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
869209002346	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
869209002347	FliG C-terminal domain; Region: FliG_C; pfam01706
869209002348	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
869209002349	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
869209002350	Flagellar assembly protein FliH; Region: FliH; pfam02108
869209002351	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
869209002352	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
869209002353	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
869209002354	Walker A motif/ATP binding site; other site
869209002355	Walker B motif; other site
869209002356	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
869209002357	GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information on the function of the TGS domain, but...; Region: TGS; cl03735
869209002358	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
869209002359	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
869209002360	Active site [active]
869209002361	ParB-like nuclease domain; Region: ParBc; cl02129
869209002362	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
869209002363	Transglycosylase; Region: Transgly; cl07896
869209002364	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
869209002365	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
869209002366	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
869209002367	catalytic motif [active]
869209002368	Zn binding site [ion binding]; other site
869209002369	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
869209002370	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
869209002371	Lumazine binding domain; Region: Lum_binding; pfam00677
869209002372	Lumazine binding domain; Region: Lum_binding; pfam00677
869209002373	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
869209002374	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
869209002375	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
869209002376	dimerization interface [polypeptide binding]; other site
869209002377	active site
869209002378	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
869209002379	homopentamer interface [polypeptide binding]; other site
869209002380	active site
869209002381	histidyl-tRNA synthetase; Region: hisS; TIGR00442
869209002382	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
869209002383	dimer interface [polypeptide binding]; other site
869209002384	motif 1; other site
869209002385	active site
869209002386	motif 2; other site
869209002387	motif 3; other site
869209002388	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
869209002389	anticodon binding site; other site
869209002390	Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130
869209002391	Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089
869209002392	NeuB family; Region: NeuB; cl00496
869209002393	SAF domain; Region: SAF; cl00555
869209002394	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
869209002395	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
869209002396	HIGH motif; other site
869209002397	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
869209002398	active site
869209002399	KMSKS motif; other site
869209002400	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
869209002401	tRNA binding surface [nucleotide binding]; other site
869209002402	anticodon binding site; other site
869209002403	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209002404	binding surface
869209002405	TPR motif; other site
869209002406	Thiamine pyrophosphokinase; Region: TPK; cl09135
869209002407	Thiamine pyrophosphokinase; Region: TPK; cl09135
869209002408	Septum formation initiator; Region: DivIC; cl11433
869209002409	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
869209002410	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
869209002411	SmpB-tmRNA interface; other site
869209002412	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
869209002413	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
869209002414	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
869209002415	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
869209002416	HemN C-terminal region; Region: HemN_C; pfam06969
869209002417	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
869209002418	TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007
869209002419	TPP-binding site; other site
869209002420	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
869209002421	PYR/PP interface [polypeptide binding]; other site
869209002422	dimer interface [polypeptide binding]; other site
869209002423	TPP binding site [chemical binding]; other site
869209002424	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
869209002425	dihydropteroate synthase; Region: DHPS; TIGR01496
869209002426	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
869209002427	substrate binding pocket [chemical binding]; other site
869209002428	dimer interface [polypeptide binding]; other site
869209002429	inhibitor binding site; inhibition site
869209002430	Uncharacterized conserved protein [Function unknown]; Region: COG1624
869209002431	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
869209002432	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
869209002433	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
869209002434	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
869209002435	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
869209002436	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
869209002437	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570
869209002438	dimerization interface 3.5A [polypeptide binding]; other site
869209002439	active site
869209002440	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
869209002441	active site
869209002442	8-oxo-dGMP binding site [chemical binding]; other site
869209002443	nudix motif; other site
869209002444	metal binding site [ion binding]; metal-binding site
869209002445	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209002446	non-specific DNA binding site [nucleotide binding]; other site
869209002447	salt bridge; other site
869209002448	sequence-specific DNA binding site [nucleotide binding]; other site
869209002449	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
869209002450	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
869209002451	anti sigma factor interaction site; other site
869209002452	regulatory phosphorylation site [posttranslational modification]; other site
869209002453	GAF domain; Region: GAF; cl00853
869209002454	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
869209002455	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
869209002456	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
869209002457	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
869209002458	active site
869209002459	metal binding site [ion binding]; metal-binding site
869209002460	Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403
869209002461	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
869209002462	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209002463	binding surface
869209002464	TPR motif; other site
869209002465	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209002466	binding surface
869209002467	TPR motif; other site
869209002468	Restriction endonuclease; Region: Mrr_cat; cl00747
869209002469	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209002470	binding surface
869209002471	TPR motif; other site
869209002472	Hef nuclease; Provisional; Region: PRK13766
869209002473	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209002474	binding surface
869209002475	TPR motif; other site
869209002476	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209002477	binding surface
869209002478	TPR motif; other site
869209002479	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209002480	binding surface
869209002481	TPR motif; other site
869209002482	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
869209002483	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869209002484	ATP binding site [chemical binding]; other site
869209002485	Mg2+ binding site [ion binding]; other site
869209002486	G-X-G motif; other site
869209002487	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
869209002488	ATP binding site [chemical binding]; other site
869209002489	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
869209002490	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
869209002491	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
869209002492	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489
869209002493	generic binding surface II; other site
869209002494	generic binding surface I; other site
869209002495	M28, and M42; Region: Zinc_peptidase_like; cl14876
869209002496	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
869209002497	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
869209002498	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
869209002499	active site
869209002500	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
869209002501	S-adenosylmethionine binding site [chemical binding]; other site
869209002502	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
869209002503	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
869209002504	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
869209002505	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
869209002506	active site
869209002507	metal binding site [ion binding]; metal-binding site
869209002508	Sporulation and spore germination; Region: Germane; cl11253
869209002509	Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620
869209002510	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
869209002511	synthetase active site [active]
869209002512	NTP binding site [chemical binding]; other site
869209002513	metal binding site [ion binding]; metal-binding site
869209002514	mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); Region: 3a0801s09; TIGR00990
869209002515	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209002516	binding surface
869209002517	TPR motif; other site
869209002518	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
869209002519	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
869209002520	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
869209002521	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209002522	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
869209002523	Flavin Reductases; Region: FlaRed; cl00801
869209002524	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected...; Region: rubredoxin_like; cd00350
869209002525	Rubredoxin; Region: Rubredoxin; pfam00301
869209002526	iron binding site [ion binding]; other site
869209002527	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209002528	Protein of unknown function DUF262; Region: DUF262; cl14890
869209002529	Uncharacterized conserved protein (DUF2081); Region: DUF2081; cl09179
869209002530	Virulence protein [General function prediction only]; Region: COG3943
869209002531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209002532	helicase 45; Provisional; Region: PTZ00424
869209002533	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
869209002534	ATP binding site [chemical binding]; other site
869209002535	Mg++ binding site [ion binding]; other site
869209002536	motif III; other site
869209002537	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869209002538	nucleotide binding region [chemical binding]; other site
869209002539	ATP-binding site [chemical binding]; other site
869209002540	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
869209002541	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209002542	Walker A/P-loop; other site
869209002543	ATP binding site [chemical binding]; other site
869209002544	Q-loop/lid; other site
869209002545	ABC transporter signature motif; other site
869209002546	Walker B; other site
869209002547	D-loop; other site
869209002548	H-loop/switch region; other site
869209002549	ABC transporter; Region: ABC_tran_2; pfam12848
869209002550	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
869209002551	Uncharacterized conserved protein [Function unknown]; Region: COG3391
869209002552	RIP metalloprotease RseP; Region: TIGR00054
869209002553	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
869209002554	active site
869209002555	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989
869209002556	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
869209002557	putative substrate binding region [chemical binding]; other site
869209002558	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
869209002559	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
869209002560	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
869209002561	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
869209002562	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
869209002563	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
869209002564	catalytic residue [active]
869209002565	putative FPP diphosphate  binding site; other site
869209002566	putative FPP binding hydrophobic cleft; other site
869209002567	dimer interface [polypeptide binding]; other site
869209002568	putative IPP diphosphate binding site; other site
869209002569	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
869209002570	hinge region; other site
869209002571	elongation factor Ts; Provisional; Region: tsf; PRK09377
869209002572	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
869209002573	Elongation factor TS; Region: EF_TS; pfam00889
869209002574	Elongation factor TS; Region: EF_TS; pfam00889
869209002575	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
869209002576	rRNA interaction site [nucleotide binding]; other site
869209002577	S8 interaction site; other site
869209002578	putative laminin-1 binding site; other site
869209002579	Maf-like protein; Region: Maf; pfam02545
869209002580	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
869209002581	active site
869209002582	dimer interface [polypeptide binding]; other site
869209002583	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
869209002584	active site
869209002585	(T/H)XGH motif; other site
869209002586	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
869209002587	Phosphopantetheine attachment site; Region: PP-binding; cl09936
869209002588	ribonuclease III; Reviewed; Region: rnc; PRK00102
869209002589	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593
869209002590	dimerization interface [polypeptide binding]; other site
869209002591	active site
869209002592	metal binding site [ion binding]; metal-binding site
869209002593	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048
869209002594	dsRNA binding site [nucleotide binding]; other site
869209002595	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
869209002596	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
869209002597	active site
869209002598	NTP binding site [chemical binding]; other site
869209002599	metal binding triad [ion binding]; metal-binding site
869209002600	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
869209002601	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
869209002602	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
869209002603	Thiamine pyrophosphokinase; Region: TPK; cl09135
869209002604	active site
869209002605	dimerization interface [polypeptide binding]; other site
869209002606	thiamine binding site [chemical binding]; other site
869209002607	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
869209002608	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In...; Region: AroH; cl10037
869209002609	homotrimer interaction site [polypeptide binding]; other site
869209002610	active site
869209002611	glycogen/starch synthases, ADP-glucose type; Region: glgA; TIGR02095
869209002612	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
869209002613	Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262
869209002614	Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262
869209002615	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
869209002616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209002617	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
869209002618	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
869209002619	motif II; other site
869209002620	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
869209002621	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
869209002622	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
869209002623	S-adenosylmethionine binding site [chemical binding]; other site
869209002624	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
869209002625	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
869209002626	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
869209002627	putative dimer interface [polypeptide binding]; other site
869209002628	catalytic triad [active]
869209002629	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209002630	non-specific DNA binding site [nucleotide binding]; other site
869209002631	salt bridge; other site
869209002632	sequence-specific DNA binding site [nucleotide binding]; other site
869209002633	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
869209002634	IHF dimer interface [polypeptide binding]; other site
869209002635	IHF - DNA interface [nucleotide binding]; other site
869209002636	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
869209002637	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
869209002638	dimer interface [polypeptide binding]; other site
869209002639	ssDNA binding site [nucleotide binding]; other site
869209002640	tetramer (dimer of dimers) interface [polypeptide binding]; other site
869209002641	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
869209002642	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
869209002643	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
869209002644	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
869209002645	replicative DNA helicase; Region: DnaB; TIGR00665
869209002646	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
869209002647	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
869209002648	Walker A motif; other site
869209002649	ATP binding site [chemical binding]; other site
869209002650	Walker B motif; other site
869209002651	DNA binding loops [nucleotide binding]
869209002652	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
869209002653	YceG-like family; Region: YceG; pfam02618
869209002654	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
869209002655	dimerization interface [polypeptide binding]; other site
869209002656	DNA primase; Validated; Region: dnaG; PRK05667
869209002657	CHC2 zinc finger; Region: zf-CHC2; cl02597
869209002658	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
869209002659	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
869209002660	active site
869209002661	metal binding site [ion binding]; metal-binding site
869209002662	interdomain interaction site; other site
869209002663	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
869209002664	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
869209002665	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
869209002666	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
869209002667	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
869209002668	DNA binding residues [nucleotide binding]
869209002669	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
869209002670	Putative zinc ribbon domain; Region: DUF164; pfam02591
869209002671	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
869209002672	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209002673	binding surface
869209002674	TPR motif; other site
869209002675	rod shape-determining protein MreB; Provisional; Region: PRK13927
869209002676	Cell division protein FtsA; Region: FtsA; cl11496
869209002677	rod shape-determining protein MreC; Region: MreC; pfam04085
869209002678	rod shape-determining protein MreD; Region: MreD; cl01087
869209002679	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
869209002680	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
869209002681	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
869209002682	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
869209002683	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
869209002684	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
869209002685	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
869209002686	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
869209002687	transcription-repair coupling factor; Region: mfd; TIGR00580
869209002688	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
869209002689	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869209002690	ATP binding site [chemical binding]; other site
869209002691	putative Mg++ binding site [ion binding]; other site
869209002692	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869209002693	nucleotide binding region [chemical binding]; other site
869209002694	ATP-binding site [chemical binding]; other site
869209002695	TRCF domain; Region: TRCF; cl04088
869209002696	Double zinc ribbon; Region: DZR; pfam12773
869209002697	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
869209002698	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
869209002699	motif II; other site
869209002700	alanine racemase; Reviewed; Region: alr; PRK00053
869209002701	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
869209002702	active site
869209002703	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
869209002704	dimer interface [polypeptide binding]; other site
869209002705	substrate binding site [chemical binding]; other site
869209002706	catalytic residues [active]
869209002707	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
869209002708	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
869209002709	gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521
869209002710	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
869209002711	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
869209002712	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209002713	Walker A/P-loop; other site
869209002714	ATP binding site [chemical binding]; other site
869209002715	Q-loop/lid; other site
869209002716	ABC transporter signature motif; other site
869209002717	Walker B; other site
869209002718	D-loop; other site
869209002719	H-loop/switch region; other site
869209002720	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
869209002721	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
869209002722	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
869209002723	Substrate binding site [chemical binding]; other site
869209002724	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
869209002725	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
869209002726	NADP binding site [chemical binding]; other site
869209002727	active site
869209002728	putative substrate binding site [chemical binding]; other site
869209002729	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
869209002730	Protein export membrane protein; Region: SecD_SecF; cl14618
869209002731	Protein export membrane protein; Region: SecD_SecF; cl14618
869209002732	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404
869209002733	lipoyl-biotinyl attachment site [posttranslational modification]; other site
869209002734	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
869209002735	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
869209002736	Outer membrane efflux protein; Region: OEP; pfam02321
869209002737	Outer membrane efflux protein; Region: OEP; pfam02321
869209002738	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
869209002739	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
869209002740	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
869209002741	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
869209002742	active site
869209002743	PseudoU_synth:  Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families.  This group consists of...; Region: PseudoU_synth; cl00130
869209002744	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
869209002745	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
869209002746	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
869209002747	active site
869209002748	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
869209002749	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
869209002750	catalytic residue [active]
869209002751	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209002752	Competence protein; Region: Competence; cl00471
869209002753	PilZ domain; Region: PilZ; cl01260
869209002754	CAAX amino terminal protease self- immunity; Region: Abi; cl00558
869209002755	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
869209002756	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342
869209002757	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
869209002758	catalytic residue [active]
869209002759	cytidylate kinase; Provisional; Region: PRK04182
869209002760	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
869209002761	CMP-binding site; other site
869209002762	The sites determining sugar specificity; other site
869209002763	hypothetical protein; Provisional; Region: PRK11820
869209002764	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
869209002765	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
869209002766	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
869209002767	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
869209002768	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
869209002769	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
869209002770	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
869209002771	D-xylulose kinases, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809
869209002772	N- and C-terminal domain interface [polypeptide binding]; other site
869209002773	D-xylulose kinase; Region: XylB; TIGR01312
869209002774	active site
869209002775	catalytic site [active]
869209002776	metal binding site [ion binding]; metal-binding site
869209002777	xylulose binding site [chemical binding]; other site
869209002778	ATP binding site [chemical binding]; other site
869209002779	putative homodimer interface [polypeptide binding]; other site
869209002780	Cupin domain; Region: Cupin_2; cl09118
869209002781	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
869209002782	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
869209002783	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
869209002784	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542
869209002785	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
869209002786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209002787	active site
869209002788	phosphorylation site [posttranslational modification]
869209002789	intermolecular recognition site; other site
869209002790	dimerization interface [polypeptide binding]; other site
869209002791	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209002792	Walker A motif; other site
869209002793	ATP binding site [chemical binding]; other site
869209002794	Walker B motif; other site
869209002795	arginine finger; other site
869209002796	Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091
869209002797	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
869209002798	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
869209002799	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
869209002800	dimer interface [polypeptide binding]; other site
869209002801	phosphorylation site [posttranslational modification]
869209002802	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869209002803	ATP binding site [chemical binding]; other site
869209002804	Mg2+ binding site [ion binding]; other site
869209002805	G-X-G motif; other site
869209002806	DNA polymerase III, gamma/tau subunits [DNA replication, recombination, and repair]; Region: DnaX; COG2812
869209002807	DNA polymerase III, gamma/tau subunits [DNA replication, recombination, and repair]; Region: DnaX; COG2812
869209002808	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209002809	Colicin V production protein; Region: Colicin_V; cl00567
869209002810	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
869209002811	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785
869209002812	active site
869209002813	homodimer interface [polypeptide binding]; other site
869209002814	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
869209002815	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
869209002816	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
869209002817	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
869209002818	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
869209002819	Walker A/P-loop; other site
869209002820	ATP binding site [chemical binding]; other site
869209002821	Q-loop/lid; other site
869209002822	ABC transporter signature motif; other site
869209002823	Walker B; other site
869209002824	D-loop; other site
869209002825	H-loop/switch region; other site
869209002826	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
869209002827	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
869209002828	Walker A/P-loop; other site
869209002829	ATP binding site [chemical binding]; other site
869209002830	Q-loop/lid; other site
869209002831	ABC transporter signature motif; other site
869209002832	Walker B; other site
869209002833	D-loop; other site
869209002834	H-loop/switch region; other site
869209002835	Cobalt transport protein; Region: CbiQ; cl00463
869209002836	trigger factor; Provisional; Region: tig; PRK01490
869209002837	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
869209002838	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
869209002839	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
869209002840	oligomer interface [polypeptide binding]; other site
869209002841	active site residues [active]
869209002842	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
869209002843	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
869209002844	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209002845	Walker A motif; other site
869209002846	ATP binding site [chemical binding]; other site
869209002847	Walker B motif; other site
869209002848	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
869209002849	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
869209002850	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209002851	DEAD-like helicases superfamily; Region: DEXDc; smart00487
869209002852	ATP binding site [chemical binding]; other site
869209002853	putative Mg++ binding site [ion binding]; other site
869209002854	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869209002855	nucleotide binding region [chemical binding]; other site
869209002856	ATP-binding site [chemical binding]; other site
869209002857	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
869209002858	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
869209002859	Walker A/P-loop; other site
869209002860	ATP binding site [chemical binding]; other site
869209002861	Q-loop/lid; other site
869209002862	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
869209002863	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278
869209002864	Q-loop/lid; other site
869209002865	ABC transporter signature motif; other site
869209002866	Walker B; other site
869209002867	D-loop; other site
869209002868	H-loop/switch region; other site
869209002869	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
869209002870	Protein of unknown function (DUF541); Region: SIMPL; cl01077
869209002871	seryl-tRNA synthetase; Provisional; Region: PRK05431
869209002872	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
869209002873	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
869209002874	dimer interface [polypeptide binding]; other site
869209002875	active site
869209002876	motif 1; other site
869209002877	motif 2; other site
869209002878	motif 3; other site
869209002879	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
869209002880	Domain of unknown function DUF20; Region: UPF0118; cl00465
869209002881	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
869209002882	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
869209002883	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
869209002884	DEAD_2; Region: DEAD_2; cl14887
869209002885	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209002886	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
869209002887	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406
869209002888	NAD(P) binding site [chemical binding]; other site
869209002889	LDH/MDH dimer interface [polypeptide binding]; other site
869209002890	substrate binding site [chemical binding]; other site
869209002891	fumarate hydratase; Reviewed; Region: fumC; PRK00485
869209002892	Class II fumarases; Region: Fumarase_classII; cd01362
869209002893	active site
869209002894	tetramer interface [polypeptide binding]; other site
869209002895	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
869209002896	Cysteine-rich domain; Region: CCG; pfam02754
869209002897	Cysteine-rich domain; Region: CCG; pfam02754
869209002898	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
869209002899	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
869209002900	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831
869209002901	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
869209002902	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
869209002903	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
869209002904	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
869209002905	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
869209002906	FAD binding pocket [chemical binding]; other site
869209002907	FAD binding motif [chemical binding]; other site
869209002908	phosphate binding motif [ion binding]; other site
869209002909	beta-alpha-beta structure motif; other site
869209002910	NAD binding pocket [chemical binding]; other site
869209002911	Iron coordination center [ion binding]; other site
869209002912	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
869209002913	catalytic loop [active]
869209002914	iron binding site [ion binding]; other site
869209002915	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
869209002916	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
869209002917	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
869209002918	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209002919	Cache domain; Region: Cache_1; pfam02743
869209002920	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209002921	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
869209002922	active site
869209002923	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
869209002924	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
869209002925	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
869209002926	putative transposase OrfB; Reviewed; Region: PHA02517
869209002927	Integrase core domain; Region: rve; cl01316
869209002928	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
869209002929	active site
869209002930	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
869209002931	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
869209002932	MatE; Region: MatE; cl10513
869209002933	LicD family; Region: LicD; cl01378
869209002934	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
869209002935	active site
869209002936	nucleotide binding site [chemical binding]; other site
869209002937	HIGH motif; other site
869209002938	KMSKS motif; other site
869209002939	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209002940	non-specific DNA binding site [nucleotide binding]; other site
869209002941	salt bridge; other site
869209002942	sequence-specific DNA binding site [nucleotide binding]; other site
869209002943	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
869209002944	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
869209002945	active site
869209002946	HIGH motif; other site
869209002947	KMSKS motif; other site
869209002948	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
869209002949	tRNA binding surface [nucleotide binding]; other site
869209002950	anticodon binding site; other site
869209002951	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human tyrosyl-; Region: tRNA_bindingDomain; cl00320
869209002952	putative tRNA-binding site [nucleotide binding]; other site
869209002953	FemAB family; Region: FemAB; cl11444
869209002954	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
869209002955	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
869209002956	Domain of unknown function (DUF1926); Region: DUF1926; pfam09095
869209002957	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
869209002958	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
869209002959	RnfE family; Region: NQR2_RnfD_RnfE; cl00779
869209002960	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
869209002961	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
869209002962	Divergent PAP2 family; Region: DUF212; cl00855
869209002963	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
869209002964	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
869209002965	active site
869209002966	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
869209002967	active site
869209002968	NTP binding site [chemical binding]; other site
869209002969	metal binding triad [ion binding]; metal-binding site
869209002970	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
869209002971	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
869209002972	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
869209002973	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
869209002974	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
869209002975	active site
869209002976	HIGH motif; other site
869209002977	dimer interface [polypeptide binding]; other site
869209002978	KMSKS motif; other site
869209002979	glycogen synthase; Provisional; Region: glgA; PRK00654
869209002980	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
869209002981	ADP-binding pocket [chemical binding]; other site
869209002982	homodimer interface [polypeptide binding]; other site
869209002983	aspartate aminotransferase; Provisional; Region: PRK06836
869209002984	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
869209002985	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869209002986	homodimer interface [polypeptide binding]; other site
869209002987	catalytic residue [active]
869209002988	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
869209002989	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
869209002990	TM-ABC transporter signature motif; other site
869209002991	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
869209002992	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
869209002993	Walker A/P-loop; other site
869209002994	ATP binding site [chemical binding]; other site
869209002995	Q-loop/lid; other site
869209002996	ABC transporter signature motif; other site
869209002997	Walker B; other site
869209002998	D-loop; other site
869209002999	H-loop/switch region; other site
869209003000	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
869209003001	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
869209003002	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
869209003003	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
869209003004	DNA binding site [nucleotide binding]
869209003005	domain linker motif; other site
869209003006	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
869209003007	ligand binding site [chemical binding]; other site
869209003008	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
869209003009	Putative carbohydrate binding domain; Region: CBM_X; cl05621
869209003010	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
869209003011	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
869209003012	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
869209003013	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
869209003014	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
869209003015	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
869209003016	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
869209003017	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
869209003018	S-adenosylmethionine binding site [chemical binding]; other site
869209003019	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209003020	binding surface
869209003021	TPR motif; other site
869209003022	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209003023	binding surface
869209003024	TPR motif; other site
869209003025	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209003026	binding surface
869209003027	TPR motif; other site
869209003028	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209003029	binding surface
869209003030	TPR motif; other site
869209003031	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
869209003032	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
869209003033	glycerate dehydrogenase; Provisional; Region: PRK06487
869209003034	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209003035	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
869209003036	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
869209003037	substrate binding site [chemical binding]; other site
869209003038	ligand binding site [chemical binding]; other site
869209003039	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577
869209003040	substrate binding site [chemical binding]; other site
869209003041	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209003042	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
869209003043	C-terminal domain interface [polypeptide binding]; other site
869209003044	sugar binding site [chemical binding]; other site
869209003045	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
869209003046	MatE; Region: MatE; cl10513
869209003047	MatE; Region: MatE; cl10513
869209003048	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
869209003049	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
869209003050	trimer interface [polypeptide binding]; other site
869209003051	active site
869209003052	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
869209003053	catalytic site [active]
869209003054	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
869209003055	catalytic motif [active]
869209003056	Zn binding site [ion binding]; other site
869209003057	Sulfate transporter family; Region: Sulfate_transp; cl00967
869209003058	Permease family; Region: Xan_ur_permease; pfam00860
869209003059	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
869209003060	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
869209003061	active site
869209003062	HIGH motif; other site
869209003063	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
869209003064	active site
869209003065	KMSKS motif; other site
869209003066	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
869209003067	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
869209003068	Walker A/P-loop; other site
869209003069	ATP binding site [chemical binding]; other site
869209003070	Q-loop/lid; other site
869209003071	ABC transporter signature motif; other site
869209003072	Walker B; other site
869209003073	D-loop; other site
869209003074	H-loop/switch region; other site
869209003075	hypothetical protein; Provisional; Region: PRK11770
869209003076	Domain of unknown function (DUF307); Region: DUF307; pfam03733
869209003077	Domain of unknown function (DUF307); Region: DUF307; pfam03733
869209003078	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209003079	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
869209003080	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209003081	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
869209003082	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209003083	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
869209003084	flagellin; Provisional; Region: PRK12804
869209003085	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
869209003086	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
869209003087	flagellin; Provisional; Region: PRK12804
869209003088	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
869209003089	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
869209003090	FlaG protein; Region: FlaG; cl00591
869209003091	flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664
869209003092	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
869209003093	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
869209003094	PilZ domain; Region: PilZ; cl01260
869209003095	Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520
869209003096	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
869209003097	Global regulator protein family; Region: CsrA; cl00670
869209003098	FliW protein; Region: FliW; cl00740
869209003099	flagellar hook-associated protein FlgL; Validated; Region: PRK06663
869209003100	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
869209003101	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665
869209003102	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
869209003103	Rod binding protein; Region: Rod-binding; cl01626
869209003104	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816
869209003105	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
869209003106	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
869209003107	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
869209003108	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
869209003109	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
869209003110	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
869209003111	metal binding site [ion binding]; metal-binding site
869209003112	active site
869209003113	I-site; other site
869209003114	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
869209003115	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
869209003116	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
869209003117	ligand binding site [chemical binding]; other site
869209003118	oligomer interface [polypeptide binding]; other site
869209003119	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651
869209003120	dimer interface [polypeptide binding]; other site
869209003121	N-terminal domain interface [polypeptide binding]; other site
869209003122	sulfate 1 binding site; other site
869209003123	transcription termination factor Rho; Provisional; Region: rho; PRK09376
869209003124	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
869209003125	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459
869209003126	RNA binding site [nucleotide binding]; other site
869209003127	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128
869209003128	multimer interface [polypeptide binding]; other site
869209003129	Walker A motif; other site
869209003130	ATP binding site [chemical binding]; other site
869209003131	Walker B motif; other site
869209003132	Polymer-forming cytoskeletal; Region: Bactofilin; cl09137
869209003133	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
869209003134	IHF dimer interface [polypeptide binding]; other site
869209003135	IHF - DNA interface [nucleotide binding]; other site
869209003136	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
869209003137	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
869209003138	putative acyl-acceptor binding pocket; other site
869209003139	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
869209003140	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
869209003141	Sporulation related domain; Region: SPOR; cl10051
869209003142	putative efflux protein, MATE family; Region: matE; TIGR00797
869209003143	MatE; Region: MatE; cl10513
869209003144	MatE; Region: MatE; cl10513
869209003145	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
869209003146	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
869209003147	ornithine carbamoyltransferase; Validated; Region: PRK02102
869209003148	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
869209003149	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209003150	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
869209003151	DHH family; Region: DHH; pfam01368
869209003152	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869209003153	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209003154	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209003155	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515
869209003156	active site
869209003157	dimerization interface [polypeptide binding]; other site
869209003158	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
869209003159	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
869209003160	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
869209003161	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
869209003162	Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022
869209003163	Bacterial sugar transferase; Region: Bac_transf; cl00939
869209003164	GcpE protein; Region: GcpE; pfam04551
869209003165	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
869209003166	ATP synthase subunit C; Region: ATP-synt_C; cl00466
869209003167	V-type ATP synthase subunit I; Validated; Region: PRK05771
869209003168	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
869209003169	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209003170	Walker A motif; other site
869209003171	ATP binding site [chemical binding]; other site
869209003172	Walker B motif; other site
869209003173	ATP synthase subunit D; Region: ATP-synt_D; cl00613
869209003174	V-type ATP synthase subunit A; Provisional; Region: PRK04192
869209003175	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
869209003176	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
869209003177	Walker A motif/ATP binding site; other site
869209003178	Walker B motif; other site
869209003179	Protein of unknown function (DUF2764); Region: DUF2764; pfam10962
869209003180	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
869209003181	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
869209003182	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
869209003183	active site
869209003184	catalytic residues [active]
869209003185	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
869209003186	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
869209003187	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
869209003188	FtsX-like permease family; Region: FtsX; pfam02687
869209003189	2-isopropylmalate synthase; Validated; Region: PRK03739
869209003190	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
869209003191	active site
869209003192	catalytic residues [active]
869209003193	metal binding site [ion binding]; metal-binding site
869209003194	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
869209003195	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
869209003196	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
869209003197	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
869209003198	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
869209003199	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
869209003200	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
869209003201	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
869209003202	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
869209003203	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
869209003204	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
869209003205	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
869209003206	Sel1 repeat; Region: Sel1; cl02723
869209003207	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209003208	non-specific DNA binding site [nucleotide binding]; other site
869209003209	salt bridge; other site
869209003210	sequence-specific DNA binding site [nucleotide binding]; other site
869209003211	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
869209003212	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
869209003213	TPP-binding site [chemical binding]; other site
869209003214	dimer interface [polypeptide binding]; other site
869209003215	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
869209003216	PYR/PP interface [polypeptide binding]; other site
869209003217	dimer interface [polypeptide binding]; other site
869209003218	TPP binding site [chemical binding]; other site
869209003219	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
869209003220	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
869209003221	active site
869209003222	phosphorylation site [posttranslational modification]
869209003223	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
869209003224	FMN binding site [chemical binding]; other site
869209003225	dimer interface [polypeptide binding]; other site
869209003226	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
869209003227	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
869209003228	PYR/PP interface [polypeptide binding]; other site
869209003229	dimer interface [polypeptide binding]; other site
869209003230	TPP binding site [chemical binding]; other site
869209003231	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
869209003232	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
869209003233	TPP-binding site [chemical binding]; other site
869209003234	dimer interface [polypeptide binding]; other site
869209003235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
869209003236	Uncharacterized conserved protein [Function unknown]; Region: COG1543
869209003237	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
869209003238	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
869209003239	Sulfatase; Region: Sulfatase; cl10460
869209003240	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
869209003241	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
869209003242	active site
869209003243	metal binding site [ion binding]; metal-binding site
869209003244	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
869209003245	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
869209003246	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869209003247	homodimer interface [polypeptide binding]; other site
869209003248	catalytic residue [active]
869209003249	CotH protein; Region: CotH; pfam08757
869209003250	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
869209003251	putative metal binding residues [ion binding]; other site
869209003252	signature motif; other site
869209003253	dimer interface [polypeptide binding]; other site
869209003254	polyP binding site; other site
869209003255	active site
869209003256	substrate binding site [chemical binding]; other site
869209003257	acceptor-phosphate pocket; other site
869209003258	CotH protein; Region: CotH; pfam08757
869209003259	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
869209003260	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
869209003261	Clp amino terminal domain; Region: Clp_N; pfam02861
869209003262	Clp amino terminal domain; Region: Clp_N; pfam02861
869209003263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209003264	Walker A motif; other site
869209003265	ATP binding site [chemical binding]; other site
869209003266	Walker B motif; other site
869209003267	arginine finger; other site
869209003268	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209003269	Walker A motif; other site
869209003270	ATP binding site [chemical binding]; other site
869209003271	Walker B motif; other site
869209003272	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
869209003273	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
869209003274	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
869209003275	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
869209003276	Peptidase M16C associated; Region: M16C_assoc; pfam08367
869209003277	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
869209003278	FliG C-terminal domain; Region: FliG_C; pfam01706
869209003279	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
869209003280	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
869209003281	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
869209003282	protein binding site [polypeptide binding]; other site
869209003283	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
869209003284	protein binding site [polypeptide binding]; other site
869209003285	Domain of unknown function DUF; Region: DUF204; pfam02659
869209003286	Domain of unknown function DUF; Region: DUF204; pfam02659
869209003287	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
869209003288	dimer interface [polypeptide binding]; other site
869209003289	active site
869209003290	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
869209003291	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228
869209003292	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228
869209003293	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
869209003294	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
869209003295	active site
869209003296	substrate binding site [chemical binding]; other site
869209003297	Mg2+ binding site [ion binding]; other site
869209003298	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
869209003299	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
869209003300	putative active site [active]
869209003301	putative metal binding site [ion binding]; other site
869209003302	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869209003303	ATP binding site [chemical binding]; other site
869209003304	putative Mg++ binding site [ion binding]; other site
869209003305	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869209003306	nucleotide binding region [chemical binding]; other site
869209003307	ATP-binding site [chemical binding]; other site
869209003308	Helicase associated domain (HA2); Region: HA2; cl04503
869209003309	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
869209003310	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
869209003311	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
869209003312	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284
869209003313	adenylate kinase; Reviewed; Region: adk; PRK00279
869209003314	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
869209003315	AMP-binding site [chemical binding]; other site
869209003316	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
869209003317	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
869209003318	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
869209003319	active site
869209003320	HIGH motif; other site
869209003321	dimer interface [polypeptide binding]; other site
869209003322	KMSKS motif; other site
869209003323	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
869209003324	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
869209003325	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
869209003326	trimerization site [polypeptide binding]; other site
869209003327	active site
869209003328	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
869209003329	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
869209003330	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
869209003331	catalytic residue [active]
869209003332	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
869209003333	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
869209003334	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
869209003335	FeS assembly protein SufB; Region: sufB; TIGR01980
869209003336	FeS assembly ATPase SufC; Region: sufC; TIGR01978
869209003337	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
869209003338	Walker A/P-loop; other site
869209003339	ATP binding site [chemical binding]; other site
869209003340	Q-loop/lid; other site
869209003341	ABC transporter signature motif; other site
869209003342	Walker B; other site
869209003343	D-loop; other site
869209003344	H-loop/switch region; other site
869209003345	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
869209003346	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
869209003347	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
869209003348	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262
869209003349	Walker A/P-loop; other site
869209003350	ATP binding site [chemical binding]; other site
869209003351	Q-loop/lid; other site
869209003352	ABC transporter signature motif; other site
869209003353	Walker B; other site
869209003354	D-loop; other site
869209003355	H-loop/switch region; other site
869209003356	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209003357	dimer interface [polypeptide binding]; other site
869209003358	conserved gate region; other site
869209003359	putative PBP binding loops; other site
869209003360	ABC-ATPase subunit interface; other site
869209003361	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
869209003362	membrane-bound complex binding site; other site
869209003363	hinge residues; other site
869209003364	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
869209003365	substrate binding pocket [chemical binding]; other site
869209003366	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14335
869209003367	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
869209003368	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
869209003369	FeS/SAM binding site; other site
869209003370	E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies.  These domains are associated with different types of catalytic domains at  either the N-terminal or C-terminal end; Region: E_set; cl09101
869209003371	Uncharacterized ACR, COG1469; Region: DUF198; cl00642
869209003372	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
869209003373	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
869209003374	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
869209003375	homodimer interface [polypeptide binding]; other site
869209003376	NADP binding site [chemical binding]; other site
869209003377	substrate binding site [chemical binding]; other site
869209003378	recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341
869209003379	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209003380	Walker A motif; other site
869209003381	ATP binding site [chemical binding]; other site
869209003382	Walker B motif; other site
869209003383	arginine finger; other site
869209003384	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
869209003385	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
869209003386	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
869209003387	S-adenosylmethionine binding site [chemical binding]; other site
869209003388	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
869209003389	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
869209003390	FeS/SAM binding site; other site
869209003391	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267
869209003392	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
869209003393	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
869209003394	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
869209003395	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
869209003396	putative NAD(P) binding site [chemical binding]; other site
869209003397	active site
869209003398	putative substrate binding site [chemical binding]; other site
869209003399	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
869209003400	Protein of unknown function (DUF342); Region: DUF342; pfam03961
869209003401	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
869209003402	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
869209003403	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
869209003404	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
869209003405	DNA binding residues [nucleotide binding]
869209003406	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
869209003407	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
869209003408	P-loop; other site
869209003409	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723
869209003410	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
869209003411	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
869209003412	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
869209003413	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
869209003414	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017
869209003415	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
869209003416	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
869209003417	FliP family; Region: FliP; cl00593
869209003418	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
869209003419	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
869209003420	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
869209003421	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
869209003422	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
869209003423	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
869209003424	flagellar motor protein MotB; Validated; Region: motB; PRK06667
869209003425	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
869209003426	ligand binding site [chemical binding]; other site
869209003427	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
869209003428	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
869209003429	Flagellar protein (FlbD); Region: FlbD; cl00683
869209003430	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
869209003431	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
869209003432	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209003433	active site
869209003434	phosphorylation site [posttranslational modification]
869209003435	intermolecular recognition site; other site
869209003436	dimerization interface [polypeptide binding]; other site
869209003437	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
869209003438	DNA binding site [nucleotide binding]
869209003439	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
869209003440	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080
869209003441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869209003442	ATP binding site [chemical binding]; other site
869209003443	Mg2+ binding site [ion binding]; other site
869209003444	G-X-G motif; other site
869209003445	IPP transferase; Region: IPPT; cl00403
869209003446	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
869209003447	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
869209003448	Flagella basal body rod protein; Region: Flg_bb_rod; cl15245
869209003449	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
869209003450	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
869209003451	Domain of unknown function (DUF1078); Region: DUF1078; pfam06429
869209003452	Flagellar hook capping protein; Region: FlgD; cl04347
869209003453	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
869209003454	Hexokinase [Carbohydrate transport and metabolism]; Region: COG5026
869209003455	Hexokinase; Region: Hexokinase_1; pfam00349
869209003456	Hexokinase; Region: Hexokinase_2; pfam03727
869209003457	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
869209003458	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
869209003459	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209003460	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
869209003461	UvrD/REP helicase; Region: UvrD-helicase; cl14126
869209003462	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
869209003463	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
869209003464	NAD binding site [chemical binding]; other site
869209003465	substrate binding site [chemical binding]; other site
869209003466	homodimer interface [polypeptide binding]; other site
869209003467	active site
869209003468	Cupin domain; Region: Cupin_2; cl09118
869209003469	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
869209003470	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
869209003471	substrate binding site [chemical binding]; other site
869209003472	tetramer interface [polypeptide binding]; other site
869209003473	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
869209003474	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
869209003475	Catalytic site [active]
869209003476	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
869209003477	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
869209003478	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
869209003479	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
869209003480	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
869209003481	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
869209003482	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
869209003483	MatE; Region: MatE; cl10513
869209003484	MatE; Region: MatE; cl10513
869209003485	cysteine synthases; Region: cysKM; TIGR01136
869209003486	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561
869209003487	dimer interface [polypeptide binding]; other site
869209003488	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869209003489	catalytic residue [active]
869209003490	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209003491	Rrf2 family protein; Region: rrf2_super; TIGR00738
869209003492	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
869209003493	active site
869209003494	catalytic triad [active]
869209003495	oxyanion hole [active]
869209003496	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
869209003497	Cache domain; Region: Cache_1; pfam02743
869209003498	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
869209003499	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209003500	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
869209003501	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209003502	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
869209003503	THUMP domain; Region: THUMP; cl12076
869209003504	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
869209003505	Ligand Binding Site [chemical binding]; other site
869209003506	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
869209003507	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817
869209003508	putative ADP-binding pocket [chemical binding]; other site
869209003509	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
869209003510	Fe-S cluster binding site [ion binding]; other site
869209003511	active site
869209003512	primosome assembly protein PriA; Validated; Region: PRK05580
869209003513	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869209003514	ATP binding site [chemical binding]; other site
869209003515	putative Mg++ binding site [ion binding]; other site
869209003516	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209003517	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
869209003518	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
869209003519	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
869209003520	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
869209003521	SEC-C motif; Region: SEC-C; cl12132
869209003522	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
869209003523	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209003524	Walker A motif; other site
869209003525	ATP binding site [chemical binding]; other site
869209003526	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209003527	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
869209003528	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
869209003529	active site
869209003530	HslU subunit interaction site [polypeptide binding]; other site
869209003531	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
869209003532	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
869209003533	DNA binding site [nucleotide binding]
869209003534	Int/Topo IB signature motif; other site
869209003535	active site
869209003536	DNA topoisomerase I; Validated; Region: PRK05582
869209003537	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363
869209003538	active site
869209003539	interdomain interaction site; other site
869209003540	putative metal-binding site [ion binding]; other site
869209003541	nucleotide binding site [chemical binding]; other site
869209003542	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
869209003543	domain I; other site
869209003544	DNA binding groove [nucleotide binding]
869209003545	phosphate binding site [ion binding]; other site
869209003546	domain II; other site
869209003547	domain III; other site
869209003548	nucleotide binding site [chemical binding]; other site
869209003549	catalytic site [active]
869209003550	domain IV; other site
869209003551	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
869209003552	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
869209003553	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
869209003554	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209003555	binding surface
869209003556	TPR motif; other site
869209003557	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209003558	binding surface
869209003559	TPR motif; other site
869209003560	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
869209003561	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
869209003562	DNA binding site [nucleotide binding]
869209003563	Int/Topo IB signature motif; other site
869209003564	active site
869209003565	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201
869209003566	nucleotide binding site [chemical binding]; other site
869209003567	SulA interaction site; other site
869209003568	cell division protein FtsA; Region: ftsA; TIGR01174
869209003569	Cell division protein FtsA; Region: FtsA; cl11496
869209003570	Cell division protein FtsA; Region: FtsA; cl11496
869209003571	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
869209003572	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
869209003573	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
869209003574	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
869209003575	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
869209003576	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
869209003577	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
869209003578	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209003579	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
869209003580	cell division protein MraZ; Reviewed; Region: PRK00326
869209003581	MraZ protein; Region: MraZ; pfam02381
869209003582	MraZ protein; Region: MraZ; pfam02381
869209003583	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
869209003584	active site
869209003585	putative DNA-binding cleft [nucleotide binding]; other site
869209003586	dimer interface [polypeptide binding]; other site
869209003587	Domain of unknown function DUF28; Region: DUF28; cl00361
869209003588	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
869209003589	Transposase; Region: DEDD_Tnp_IS110; pfam01548
869209003590	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
869209003591	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
869209003592	active site
869209003593	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
869209003594	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
869209003595	active site
869209003596	phosphorylation site [posttranslational modification]
869209003597	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209003598	Response regulator receiver domain; Region: Response_reg; pfam00072
869209003599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209003600	active site
869209003601	phosphorylation site [posttranslational modification]
869209003602	intermolecular recognition site; other site
869209003603	dimerization interface [polypeptide binding]; other site
869209003604	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
869209003605	CheC-like family; Region: CheC; pfam04509
869209003606	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
869209003607	putative CheA interaction surface; other site
869209003608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209003609	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
869209003610	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
869209003611	putative binding surface; other site
869209003612	active site
869209003613	P2 response regulator binding domain; Region: P2; pfam07194
869209003614	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
869209003615	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869209003616	ATP binding site [chemical binding]; other site
869209003617	G-X-G motif; other site
869209003618	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
869209003619	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
869209003620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209003621	active site
869209003622	phosphorylation site [posttranslational modification]
869209003623	intermolecular recognition site; other site
869209003624	dimerization interface [polypeptide binding]; other site
869209003625	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
869209003626	DNA binding site [nucleotide binding]
869209003627	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
869209003628	Ligand Binding Site [chemical binding]; other site
869209003629	ATP synthase subunit D; Region: ATP-synt_D; cl00613
869209003630	V-type ATP synthase subunit B; Provisional; Region: PRK04196
869209003631	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
869209003632	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the...; Region: V_A-ATPase_B; cd01135
869209003633	Walker A motif homologous position; other site
869209003634	Walker B motif; other site
869209003635	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
869209003636	V-type ATP synthase subunit A; Provisional; Region: PRK04192
869209003637	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
869209003638	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
869209003639	Walker A motif/ATP binding site; other site
869209003640	Walker B motif; other site
869209003641	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
869209003642	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
869209003643	ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632
869209003644	ATP synthase subunit C; Region: ATP-synt_C; cl00466
869209003645	V-type ATP synthase subunit I; Validated; Region: PRK05771
869209003646	ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; cl00660
869209003647	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
869209003648	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
869209003649	active site
869209003650	phosphorylation site [posttranslational modification]
869209003651	Preprotein translocase SecG subunit; Region: SecG; cl09123
869209003652	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
869209003653	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
869209003654	LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167
869209003655	putative metal binding site [ion binding]; other site
869209003656	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
869209003657	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
869209003658	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
869209003659	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
869209003660	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
869209003661	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
869209003662	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
869209003663	DNA binding residues [nucleotide binding]
869209003664	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
869209003665	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209003666	Walker A/P-loop; other site
869209003667	ATP binding site [chemical binding]; other site
869209003668	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
869209003669	putative active site [active]
869209003670	catalytic site [active]
869209003671	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
869209003672	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869209003673	putative Mg++ binding site [ion binding]; other site
869209003674	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869209003675	nucleotide binding region [chemical binding]; other site
869209003676	ATP-binding site [chemical binding]; other site
869209003677	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
869209003678	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
869209003679	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
869209003680	catalytic residue [active]
869209003681	hypothetical protein; Provisional; Region: PRK13795
869209003682	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
869209003683	Active Sites [active]
869209003684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514
869209003685	Protein of unknown function (DUF497); Region: DUF497; cl01108
869209003686	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209003687	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869209003688	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
869209003689	nucleotide binding region [chemical binding]; other site
869209003690	ATP-binding site [chemical binding]; other site
869209003691	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
869209003692	S-adenosylmethionine binding site [chemical binding]; other site
869209003693	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
869209003694	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
869209003695	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
869209003696	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
869209003697	active site
869209003698	IPP transferase; Region: IPPT; cl00403
869209003699	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
869209003700	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
869209003701	S-adenosylmethionine binding site [chemical binding]; other site
869209003702	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
869209003703	substrate binding site [chemical binding]; other site
869209003704	hinge regions; other site
869209003705	ADP binding site [chemical binding]; other site
869209003706	catalytic site [active]
869209003707	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
869209003708	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209003709	binding surface
869209003710	TPR motif; other site
869209003711	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209003712	TPR motif; other site
869209003713	binding surface
869209003714	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209003715	binding surface
869209003716	TPR motif; other site
869209003717	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
869209003718	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
869209003719	Transporter associated domain; Region: CorC_HlyC; cl08393
869209003720	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
869209003721	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
869209003722	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
869209003723	Zn2+ binding site [ion binding]; other site
869209003724	Mg2+ binding site [ion binding]; other site
869209003725	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
869209003726	PhoH-like protein; Region: PhoH; cl12134
869209003727	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
869209003728	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
869209003729	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
869209003730	HIGH motif; other site
869209003731	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
869209003732	active site
869209003733	KMSKS motif; other site
869209003734	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
869209003735	tRNA binding surface [nucleotide binding]; other site
869209003736	anticodon binding site; other site
869209003737	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
869209003738	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
869209003739	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
869209003740	active site
869209003741	8-oxo-dGMP binding site [chemical binding]; other site
869209003742	nudix motif; other site
869209003743	metal binding site [ion binding]; metal-binding site
869209003744	Protein of unknown function (DUF541); Region: SIMPL; cl01077
869209003745	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
869209003746	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
869209003747	Protein of unknown function (DUF436); Region: DUF436; cl01860
869209003748	Domain of unknown function DUF21; Region: DUF21; pfam01595
869209003749	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
869209003750	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
869209003751	Transporter associated domain; Region: CorC_HlyC; cl08393
869209003752	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209003753	cofactor binding site; other site
869209003754	DNA binding site [nucleotide binding]
869209003755	substrate interaction site [chemical binding]; other site
869209003756	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
869209003757	S-adenosylmethionine binding site [chemical binding]; other site
869209003758	Tsp45I type II restriction enzyme; Region: Tsp45I; pfam06300
869209003759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209003760	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
869209003761	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
869209003762	dimer interface [polypeptide binding]; other site
869209003763	phosphorylation site [posttranslational modification]
869209003764	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869209003765	ATP binding site [chemical binding]; other site
869209003766	Mg2+ binding site [ion binding]; other site
869209003767	G-X-G motif; other site
869209003768	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
869209003769	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209003770	active site
869209003771	phosphorylation site [posttranslational modification]
869209003772	intermolecular recognition site; other site
869209003773	dimerization interface [polypeptide binding]; other site
869209003774	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
869209003775	DNA binding site [nucleotide binding]
869209003776	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
869209003777	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209003778	DpnII restriction endonuclease; Region: DpnII; pfam04556
869209003779	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408
869209003780	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
869209003781	Fasciclin domain; Region: Fasciclin; cl02663
869209003782	Uncharacterized conserved protein [Function unknown]; Region: COG1641; cl03398
869209003783	Uncharacterized conserved protein [Function unknown]; Region: COG1641; cl03398
869209003784	AIR carboxylase; Region: AIRC; cl00310
869209003785	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
869209003786	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
869209003787	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
869209003788	Ligand Binding Site [chemical binding]; other site
869209003789	MatE; Region: MatE; cl10513
869209003790	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
869209003791	Cache domain; Region: Cache_2; cl07034
869209003792	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
869209003793	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
869209003794	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209003795	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
869209003796	ATP binding site [chemical binding]; other site
869209003797	Metal binding site [ion binding]; metal-binding site
869209003798	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
869209003799	dimer interface [polypeptide binding]; other site
869209003800	ssDNA binding site [nucleotide binding]; other site
869209003801	tetramer (dimer of dimers) interface [polypeptide binding]; other site
869209003802	Uncharacterized conserved protein [Function unknown]; Region: COG4938
869209003803	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
869209003804	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209003805	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209003806	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
869209003807	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209003808	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
869209003809	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
869209003810	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
869209003811	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
869209003812	VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
869209003813	Domain of unknown function DUF87; Region: DUF87; pfam01935
869209003814	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
869209003815	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
869209003816	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209003817	Walker A motif; other site
869209003818	ATP binding site [chemical binding]; other site
869209003819	Walker B motif; other site
869209003820	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
869209003821	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209003822	Walker A motif; other site
869209003823	ATP binding site [chemical binding]; other site
869209003824	Walker B motif; other site
869209003825	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
869209003826	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
869209003827	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
869209003828	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
869209003829	VirB7 interaction site; other site
869209003830	VirB8 protein; Region: VirB8; cl01500
869209003831	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
869209003832	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209003833	cofactor binding site; other site
869209003834	DNA topoisomerase III; Provisional; Region: PRK07726
869209003835	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362
869209003836	active site
869209003837	putative interdomain interaction site [polypeptide binding]; other site
869209003838	putative metal-binding site [ion binding]; other site
869209003839	putative nucleotide binding site [chemical binding]; other site
869209003840	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986
869209003841	domain I; other site
869209003842	DNA binding groove [nucleotide binding]
869209003843	phosphate binding site [ion binding]; other site
869209003844	domain II; other site
869209003845	domain III; other site
869209003846	nucleotide binding site [chemical binding]; other site
869209003847	catalytic site [active]
869209003848	domain IV; other site
869209003849	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869209003850	Integrase core domain; Region: rve; cl01316
869209003851	serine hydroxymethyltransferase; Provisional; Region: PRK13580
869209003852	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378
869209003853	dimer interface [polypeptide binding]; other site
869209003854	glycine-pyridoxal phosphate binding site [chemical binding]; other site
869209003855	active site
869209003856	folate binding site [chemical binding]; other site
869209003857	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
869209003858	RelB antitoxin; Region: RelB; cl01171
869209003859	FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
869209003860	putative active site [active]
869209003861	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
869209003862	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
869209003863	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209003864	non-specific DNA binding site [nucleotide binding]; other site
869209003865	salt bridge; other site
869209003866	sequence-specific DNA binding site [nucleotide binding]; other site
869209003867	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
869209003868	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
869209003869	domain; Region: Glyco_hydro_2; pfam00703
869209003870	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
869209003871	active site
869209003872	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
869209003873	RNA/DNA binding site [nucleotide binding]; other site
869209003874	RRM dimerization site [polypeptide binding]; other site
869209003875	M28, and M42; Region: Zinc_peptidase_like; cl14876
869209003876	metal binding site [ion binding]; metal-binding site
869209003877	EamA-like transporter family; Region: EamA; cl01037
869209003878	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
869209003879	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
869209003880	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
869209003881	active site
869209003882	GTPase RsgA; Reviewed; Region: PRK00098
869209003883	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854
869209003884	GTPase/OB domain interface [polypeptide binding]; other site
869209003885	GTPase/Zn-binding domain interface [polypeptide binding]; other site
869209003886	GTP/Mg2+ binding site [chemical binding]; other site
869209003887	G4 box; other site
869209003888	G5 box; other site
869209003889	G1 box; other site
869209003890	Switch I region; other site
869209003891	G2 box; other site
869209003892	G3 box; other site
869209003893	Switch II region; other site
869209003894	elongation factor G; Reviewed; Region: PRK00007
869209003895	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886
869209003896	G1 box; other site
869209003897	putative GEF interaction site [polypeptide binding]; other site
869209003898	GTP/Mg2+ binding site [chemical binding]; other site
869209003899	Switch I region; other site
869209003900	G2 box; other site
869209003901	G3 box; other site
869209003902	Switch II region; other site
869209003903	G4 box; other site
869209003904	G5 box; other site
869209003905	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088
869209003906	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680
869209003907	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713
869209003908	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
869209003909	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209003910	active site
869209003911	phosphorylation site [posttranslational modification]
869209003912	intermolecular recognition site; other site
869209003913	dimerization interface [polypeptide binding]; other site
869209003914	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
869209003915	Zn2+ binding site [ion binding]; other site
869209003916	Mg2+ binding site [ion binding]; other site
869209003917	NAD synthetase; Reviewed; Region: nadE; PRK02628
869209003918	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
869209003919	multimer interface [polypeptide binding]; other site
869209003920	active site
869209003921	catalytic triad [active]
869209003922	protein interface 1 [polypeptide binding]; other site
869209003923	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553
869209003924	homodimer interface [polypeptide binding]; other site
869209003925	NAD binding pocket [chemical binding]; other site
869209003926	ATP binding pocket [chemical binding]; other site
869209003927	Mg binding site [ion binding]; other site
869209003928	active-site loop [active]
869209003929	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
869209003930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209003931	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
869209003932	GAF domain; Region: GAF; cl00853
869209003933	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209003934	Walker A motif; other site
869209003935	ATP binding site [chemical binding]; other site
869209003936	Walker B motif; other site
869209003937	arginine finger; other site
869209003938	bifunctional cytidylate kinase/ribosomal protein S1; Provisional; Region: PRK12269
869209003939	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
869209003940	CMP-binding site; other site
869209003941	The sites determining sugar specificity; other site
869209003942	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
869209003943	RNA binding site [nucleotide binding]; other site
869209003944	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
869209003945	RNA binding site [nucleotide binding]; other site
869209003946	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
869209003947	RNA binding site [nucleotide binding]; other site
869209003948	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
869209003949	RNA binding site [nucleotide binding]; other site
869209003950	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
869209003951	RNA binding site [nucleotide binding]; other site
869209003952	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
869209003953	RNA binding site [nucleotide binding]; other site
869209003954	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
869209003955	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
869209003956	RNA binding surface [nucleotide binding]; other site
869209003957	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
869209003958	active site
869209003959	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
869209003960	ScpA/B protein; Region: ScpA_ScpB; cl00598
869209003961	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
869209003962	catalytic center binding site [active]
869209003963	ATP binding site [chemical binding]; other site
869209003964	recombinase A; Provisional; Region: recA; PRK09354
869209003965	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
869209003966	hexamer interface [polypeptide binding]; other site
869209003967	Walker A motif; other site
869209003968	ATP binding site [chemical binding]; other site
869209003969	Walker B motif; other site
869209003970	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
869209003971	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655
869209003972	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
869209003973	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
869209003974	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
869209003975	putative peptidoglycan binding site; other site
869209003976	Peptidase family M23; Region: Peptidase_M23; pfam01551
869209003977	Trp repressor protein; Region: Trp_repressor; cl01121
869209003978	IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330
869209003979	PPIC-type PPIASE domain; Region: Rotamase; cl08278
869209003980	Thiamine pyrophosphokinase; Region: TPK; cl09135
869209003981	GTP-binding protein LepA; Provisional; Region: PRK05433
869209003982	LepA subfamily.  LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome.  LepA is ubiquitous in bacteria and...; Region: LepA; cd01890
869209003983	G1 box; other site
869209003984	putative GEF interaction site [polypeptide binding]; other site
869209003985	GTP/Mg2+ binding site [chemical binding]; other site
869209003986	Switch I region; other site
869209003987	G2 box; other site
869209003988	G3 box; other site
869209003989	Switch II region; other site
869209003990	G4 box; other site
869209003991	G5 box; other site
869209003992	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699
869209003993	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
869209003994	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
869209003995	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
869209003996	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
869209003997	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
869209003998	Ligand Binding Site [chemical binding]; other site
869209003999	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
869209004000	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
869209004001	5S rRNA interface [nucleotide binding]; other site
869209004002	CTC domain interface [polypeptide binding]; other site
869209004003	L16 interface [polypeptide binding]; other site
869209004004	SpoVG; Region: SpoVG; cl00915
869209004005	4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947
869209004006	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
869209004007	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
869209004008	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
869209004009	Walker A/P-loop; other site
869209004010	ATP binding site [chemical binding]; other site
869209004011	Q-loop/lid; other site
869209004012	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
869209004013	ABC transporter signature motif; other site
869209004014	Walker B; other site
869209004015	D-loop; other site
869209004016	H-loop/switch region; other site
869209004017	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
869209004018	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
869209004019	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
869209004020	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
869209004021	catalytic residue [active]
869209004022	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
869209004023	putative CheA interaction surface; other site
869209004024	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
869209004025	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
869209004026	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
869209004027	MutS domain I; Region: MutS_I; pfam01624
869209004028	MutS domain II; Region: MutS_II; pfam05188
869209004029	MutS family domain IV; Region: MutS_IV; pfam05190
869209004030	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
869209004031	Walker A/P-loop; other site
869209004032	ATP binding site [chemical binding]; other site
869209004033	Q-loop/lid; other site
869209004034	ABC transporter signature motif; other site
869209004035	Walker B; other site
869209004036	D-loop; other site
869209004037	H-loop/switch region; other site
869209004038	periplasmic chaperone; Provisional; Region: PRK10780
869209004039	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
869209004040	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
869209004041	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
869209004042	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
869209004043	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
869209004044	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
869209004045	Surface antigen; Region: Bac_surface_Ag; cl03097
869209004046	Family of unknown function (DUF490); Region: DUF490; pfam04357
869209004047	thymidylate kinase; Region: DTMP_kinase; TIGR00041
869209004048	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672
869209004049	TMP-binding site; other site
869209004050	ATP-binding site [chemical binding]; other site
869209004051	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
869209004052	Domain of unknown function (DUF814); Region: DUF814; pfam05670
869209004053	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
869209004054	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537
869209004055	FAD binding site [chemical binding]; other site
869209004056	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
869209004057	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105
869209004058	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
869209004059	Pterin binding enzyme; Region: Pterin_bind; pfam00809
869209004060	substrate binding pocket [chemical binding]; other site
869209004061	dimer interface [polypeptide binding]; other site
869209004062	inhibitor binding site; inhibition site
869209004063	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
869209004064	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
869209004065	B12 binding site [chemical binding]; other site
869209004066	cobalt ligand [ion binding]; other site
869209004067	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
869209004068	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
869209004069	active site
869209004070	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
869209004071	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
869209004072	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
869209004073	Bacterial SH3 domain; Region: SH3_3; cl02551
869209004074	Peptidase family M48; Region: Peptidase_M48; cl12018
869209004075	CHASE2 domain; Region: CHASE2; cl01732
869209004076	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
869209004077	cyclase homology domain; Region: CHD; cd07302
869209004078	nucleotidyl binding site; other site
869209004079	metal binding site [ion binding]; metal-binding site
869209004080	dimer interface [polypeptide binding]; other site
869209004081	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
869209004082	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209004083	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
869209004084	NeuB family; Region: NeuB; cl00496
869209004085	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
869209004086	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
869209004087	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
869209004088	homodimer interface [polypeptide binding]; other site
869209004089	substrate-cofactor binding pocket; other site
869209004090	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869209004091	catalytic residue [active]
869209004092	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
869209004093	RNB domain; Region: RNB; pfam00773
869209004094	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
869209004095	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
869209004096	Walker A/P-loop; other site
869209004097	ATP binding site [chemical binding]; other site
869209004098	Q-loop/lid; other site
869209004099	ABC transporter signature motif; other site
869209004100	Walker B; other site
869209004101	D-loop; other site
869209004102	H-loop/switch region; other site
869209004103	TOBE domain; Region: TOBE_2; cl01440
869209004104	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
869209004105	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
869209004106	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209004107	META domain; Region: META; cl01245
869209004108	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
869209004109	active site
869209004110	dimer interface [polypeptide binding]; other site
869209004111	metal binding site [ion binding]; metal-binding site
869209004112	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
869209004113	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
869209004114	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
869209004115	catalytic residue [active]
869209004116	Protein of unknown function (DUF3276); Region: DUF3276; cl15305
869209004117	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
869209004118	RNA/DNA hybrid binding site [nucleotide binding]; other site
869209004119	active site
869209004120	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
869209004121	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209004122	TPR motif; other site
869209004123	binding surface
869209004124	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
869209004125	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
869209004126	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
869209004127	substrate binding site [chemical binding]; other site
869209004128	hexamer interface [polypeptide binding]; other site
869209004129	metal binding site [ion binding]; metal-binding site
869209004130	transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720
869209004131	domain; Region: GreA_GreB_N; pfam03449
869209004132	C-term; Region: GreA_GreB; pfam01272
869209004133	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
869209004134	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
869209004135	intersubunit interface [polypeptide binding]; other site
869209004136	active site
869209004137	catalytic residue [active]
869209004138	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
869209004139	dimerization interface [polypeptide binding]; other site
869209004140	putative DNA binding site [nucleotide binding]; other site
869209004141	putative Zn2+ binding site [ion binding]; other site
869209004142	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
869209004143	Protein export membrane protein; Region: SecD_SecF; cl14618
869209004144	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
869209004145	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
869209004146	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
869209004147	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
869209004148	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209004149	TPR motif; other site
869209004150	binding surface
869209004151	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209004152	TPR motif; other site
869209004153	binding surface
869209004154	Polymer-forming cytoskeletal; Region: Bactofilin; cl09137
869209004155	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
869209004156	DEAD-like helicases superfamily; Region: DEXDc; smart00487
869209004157	ATP binding site [chemical binding]; other site
869209004158	Mg++ binding site [ion binding]; other site
869209004159	motif III; other site
869209004160	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869209004161	nucleotide binding region [chemical binding]; other site
869209004162	ATP-binding site [chemical binding]; other site
869209004163	DbpA RNA binding domain; Region: DbpA; pfam03880
869209004164	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886
869209004165	elongation factor G; Reviewed; Region: PRK12740
869209004166	G1 box; other site
869209004167	putative GEF interaction site [polypeptide binding]; other site
869209004168	GTP/Mg2+ binding site [chemical binding]; other site
869209004169	Switch I region; other site
869209004170	G2 box; other site
869209004171	G3 box; other site
869209004172	Switch II region; other site
869209004173	G4 box; other site
869209004174	G5 box; other site
869209004175	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091
869209004176	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434
869209004177	mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097
869209004178	RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467
869209004179	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
869209004180	metal-binding site [ion binding]
869209004181	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
869209004182	dimerization interface [polypeptide binding]; other site
869209004183	putative DNA binding site [nucleotide binding]; other site
869209004184	putative Zn2+ binding site [ion binding]; other site
869209004185	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
869209004186	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
869209004187	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
869209004188	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
869209004189	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869209004190	Coenzyme A binding pocket [chemical binding]; other site
869209004191	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869209004192	Coenzyme A binding pocket [chemical binding]; other site
869209004193	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
869209004194	putative active site [active]
869209004195	Predicted membrane protein [Function unknown]; Region: COG2364
869209004196	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
869209004197	transmembrane helices; other site
869209004198	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368
869209004199	Omptin family; Region: Omptin; cl01886
869209004200	Predicted transcriptional regulator [Transcription]; Region: COG2378
869209004201	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209004202	Peptidase family M48; Region: Peptidase_M48; cl12018
869209004203	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
869209004204	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
869209004205	Cupin domain; Region: Cupin_2; cl09118
869209004206	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
869209004207	putative catalytic residues [active]
869209004208	catalytic nucleophile [active]
869209004209	Recombinase; Region: Recombinase; pfam07508
869209004210	hypothetical protein; Validated; Region: PRK08116
869209004211	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209004212	Walker A motif; other site
869209004213	ATP binding site [chemical binding]; other site
869209004214	Walker B motif; other site
869209004215	arginine finger; other site
869209004216	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
869209004217	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
869209004218	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
869209004219	H+ Antiporter protein; Region: 2A0121; TIGR00900
869209004220	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
869209004221	putative substrate translocation pore; other site
869209004222	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209004223	non-specific DNA binding site [nucleotide binding]; other site
869209004224	salt bridge; other site
869209004225	sequence-specific DNA binding site [nucleotide binding]; other site
869209004226	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
869209004227	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
869209004228	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
869209004229	catalytic residues [active]
869209004230	catalytic nucleophile [active]
869209004231	Presynaptic Site I dimer interface [polypeptide binding]; other site
869209004232	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
869209004233	Synaptic Flat tetramer interface [polypeptide binding]; other site
869209004234	Synaptic Site I dimer interface [polypeptide binding]; other site
869209004235	DNA binding site [nucleotide binding]
869209004236	Recombinase; Region: Recombinase; pfam07508
869209004237	Helix-turn-helix domain; Region: HTH_16; pfam12645
869209004238	DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920
869209004239	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
869209004240	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
869209004241	Int/Topo IB signature motif; other site
869209004242	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
869209004243	Helix-turn-helix domain; Region: HTH_16; pfam12645
869209004244	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
869209004245	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
869209004246	DNA binding residues [nucleotide binding]
869209004247	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
869209004248	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
869209004249	FeS/SAM binding site; other site
869209004250	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
869209004251	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
869209004252	S-adenosylmethionine binding site [chemical binding]; other site
869209004253	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209004254	non-specific DNA binding site [nucleotide binding]; other site
869209004255	salt bridge; other site
869209004256	sequence-specific DNA binding site [nucleotide binding]; other site
869209004257	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
869209004258	Tet(M)-like subfamily.  Tet(M), Tet(O), Tet(W), and OtrA are tetracycline resistance genes found in Gram-positive and Gram-negative bacteria.  Tetracyclines inhibit protein synthesis by preventing aminoacyl-tRNA from binding to the ribosomal acceptor...; Region: TetM_like; cd04168
869209004259	G1 box; other site
869209004260	putative GEF interaction site [polypeptide binding]; other site
869209004261	GTP/Mg2+ binding site [chemical binding]; other site
869209004262	Switch I region; other site
869209004263	G2 box; other site
869209004264	G3 box; other site
869209004265	Switch II region; other site
869209004266	G4 box; other site
869209004267	G5 box; other site
869209004268	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
869209004269	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines...; Region: Tet_like_IV; cd01684
869209004270	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a GTP-...; Region: Tet_C; cd03711
869209004271	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
869209004272	ATP-binding site [chemical binding]; other site
869209004273	Gluconate-6-phosphate binding site [chemical binding]; other site
869209004274	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
869209004275	Transcriptional regulator [Transcription]; Region: LysR; COG0583
869209004276	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209004277	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
869209004278	dimerization interface [polypeptide binding]; other site
869209004279	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
869209004280	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
869209004281	Domain of unknown function (DUF369); Region: DUF369; cl00950
869209004282	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315
869209004283	TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007
869209004284	TPP-binding site; other site
869209004285	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
869209004286	PYR/PP interface [polypeptide binding]; other site
869209004287	dimer interface [polypeptide binding]; other site
869209004288	TPP binding site [chemical binding]; other site
869209004289	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
869209004290	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
869209004291	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
869209004292	4Fe-4S binding domain; Region: Fer4_5; pfam12801
869209004293	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
869209004294	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966
869209004295	catalytic residues [active]
869209004296	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
869209004297	active site
869209004298	8-oxo-dGMP binding site [chemical binding]; other site
869209004299	nudix motif; other site
869209004300	metal binding site [ion binding]; metal-binding site
869209004301	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
869209004302	S-adenosylmethionine binding site [chemical binding]; other site
869209004303	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
869209004304	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869209004305	ATP binding site [chemical binding]; other site
869209004306	Mg2+ binding site [ion binding]; other site
869209004307	G-X-G motif; other site
869209004308	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
869209004309	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944
869209004310	active site
869209004311	phosphorylation site [posttranslational modification]
869209004312	intermolecular recognition site; other site
869209004313	dimerization interface [polypeptide binding]; other site
869209004314	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170
869209004315	DNA binding residues [nucleotide binding]
869209004316	dimerization interface [polypeptide binding]; other site
869209004317	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
869209004318	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
869209004319	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
869209004320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944
869209004321	active site
869209004322	phosphorylation site [posttranslational modification]
869209004323	intermolecular recognition site; other site
869209004324	dimerization interface [polypeptide binding]; other site
869209004325	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209004326	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
869209004327	Histidine kinase; Region: HisKA_3; pfam07730
869209004328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
869209004329	Archaeal ATPase; Region: Arch_ATPase; pfam01637
869209004330	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
869209004331	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
869209004332	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
869209004333	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335
869209004334	FeS/SAM binding site; other site
869209004335	radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085
869209004336	Fic/DOC family; Region: Fic; cl00960
869209004337	mobile mystery protein A; Region: mob_myst_A; TIGR02612
869209004338	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209004339	non-specific DNA binding site [nucleotide binding]; other site
869209004340	salt bridge; other site
869209004341	sequence-specific DNA binding site [nucleotide binding]; other site
869209004342	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
869209004343	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
869209004344	Cupin domain; Region: Cupin_2; cl09118
869209004345	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
869209004346	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
869209004347	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
869209004348	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
869209004349	cofactor binding site; other site
869209004350	DNA binding site [nucleotide binding]
869209004351	substrate interaction site [chemical binding]; other site
869209004352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209004353	NgoBV restriction endonuclease; Region: RE_NgoBV; pfam09564
869209004354	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209004355	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
869209004356	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
869209004357	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869209004358	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209004359	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209004360	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
869209004361	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869209004362	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209004363	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209004364	Histidine kinase; Region: HisKA_3; pfam07730
869209004365	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869209004366	ATP binding site [chemical binding]; other site
869209004367	Mg2+ binding site [ion binding]; other site
869209004368	G-X-G motif; other site
869209004369	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
869209004370	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
869209004371	Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150
869209004372	DNA helicase, putative; Region: TIGR00376
869209004373	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
869209004374	DNA topoisomerase I; Validated; Region: PRK06599
869209004375	Sulfatase; Region: Sulfatase; cl10460
869209004376	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
869209004377	Beta-lactamase; Region: Beta-lactamase; cl01009
869209004378	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
869209004379	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
869209004380	domain; Region: Glyco_hydro_2; pfam00703
869209004381	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
869209004382	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
869209004383	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
869209004384	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
869209004385	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209004386	dimer interface [polypeptide binding]; other site
869209004387	conserved gate region; other site
869209004388	putative PBP binding loops; other site
869209004389	ABC-ATPase subunit interface; other site
869209004390	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
869209004391	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209004392	dimer interface [polypeptide binding]; other site
869209004393	conserved gate region; other site
869209004394	putative PBP binding loops; other site
869209004395	ABC-ATPase subunit interface; other site
869209004396	TSCPD domain; Region: TSCPD; cl14834
869209004397	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
869209004398	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209004399	Walker A/P-loop; other site
869209004400	ATP binding site [chemical binding]; other site
869209004401	Q-loop/lid; other site
869209004402	ABC transporter signature motif; other site
869209004403	Walker B; other site
869209004404	D-loop; other site
869209004405	H-loop/switch region; other site
869209004406	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
869209004407	TM-ABC transporter signature motif; other site
869209004408	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984
869209004409	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
869209004410	zinc binding site [ion binding]; other site
869209004411	putative ligand binding site [chemical binding]; other site
869209004412	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
869209004413	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
869209004414	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
869209004415	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
869209004416	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
869209004417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209004418	dimer interface [polypeptide binding]; other site
869209004419	conserved gate region; other site
869209004420	putative PBP binding loops; other site
869209004421	ABC-ATPase subunit interface; other site
869209004422	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
869209004423	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209004424	dimer interface [polypeptide binding]; other site
869209004425	conserved gate region; other site
869209004426	putative PBP binding loops; other site
869209004427	ABC-ATPase subunit interface; other site
869209004428	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
869209004429	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
869209004430	Walker A/P-loop; other site
869209004431	ATP binding site [chemical binding]; other site
869209004432	Q-loop/lid; other site
869209004433	ABC transporter signature motif; other site
869209004434	Walker B; other site
869209004435	D-loop; other site
869209004436	H-loop/switch region; other site
869209004437	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
869209004438	PhoU domain; Region: PhoU; pfam01895
869209004439	PhoU domain; Region: PhoU; pfam01895
869209004440	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
869209004441	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
869209004442	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
869209004443	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
869209004444	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
869209004445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209004446	active site
869209004447	phosphorylation site [posttranslational modification]
869209004448	intermolecular recognition site; other site
869209004449	dimerization interface [polypeptide binding]; other site
869209004450	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
869209004451	DNA binding site [nucleotide binding]
869209004452	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
869209004453	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
869209004454	dimerization interface [polypeptide binding]; other site
869209004455	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
869209004456	dimer interface [polypeptide binding]; other site
869209004457	phosphorylation site [posttranslational modification]
869209004458	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869209004459	ATP binding site [chemical binding]; other site
869209004460	Mg2+ binding site [ion binding]; other site
869209004461	G-X-G motif; other site
869209004462	hypothetical protein; Reviewed; Region: PRK00024
869209004463	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
869209004464	MPN+ (JAMM) motif; other site
869209004465	Zinc-binding site [ion binding]; other site
869209004466	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
869209004467	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
869209004468	protein binding site [polypeptide binding]; other site
869209004469	excinuclease ABC subunit B; Provisional; Region: PRK05298
869209004470	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869209004471	ATP binding site [chemical binding]; other site
869209004472	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869209004473	nucleotide binding region [chemical binding]; other site
869209004474	ATP-binding site [chemical binding]; other site
869209004475	Ultra-violet resistance protein B; Region: UvrB; pfam12344
869209004476	UvrB/uvrC motif; Region: UVR; pfam02151
869209004477	S-layer homology domain; Region: SLH; pfam00395
869209004478	S-layer homology domain; Region: SLH; pfam00395
869209004479	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
869209004480	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
869209004481	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
869209004482	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
869209004483	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
869209004484	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
869209004485	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209004486	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
869209004487	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318
869209004488	putative dimer interface [polypeptide binding]; other site
869209004489	putative anticodon binding site; other site
869209004490	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776
869209004491	homodimer interface [polypeptide binding]; other site
869209004492	motif 1; other site
869209004493	motif 2; other site
869209004494	active site
869209004495	motif 3; other site
869209004496	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
869209004497	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
869209004498	ligand binding site [chemical binding]; other site
869209004499	flexible hinge region; other site
869209004500	GMP synthase; Reviewed; Region: guaA; PRK00074
869209004501	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
869209004502	AMP/PPi binding site [chemical binding]; other site
869209004503	candidate oxyanion hole; other site
869209004504	catalytic triad [active]
869209004505	potential glutamine specificity residues [chemical binding]; other site
869209004506	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
869209004507	ATP Binding subdomain [chemical binding]; other site
869209004508	Ligand Binding sites [chemical binding]; other site
869209004509	Dimerization subdomain; other site
869209004510	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
869209004511	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
869209004512	metal binding site [ion binding]; metal-binding site
869209004513	active site
869209004514	I-site; other site
869209004515	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
869209004516	Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; cl01958
869209004517	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
869209004518	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
869209004519	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209004520	dimer interface [polypeptide binding]; other site
869209004521	conserved gate region; other site
869209004522	putative PBP binding loops; other site
869209004523	ABC-ATPase subunit interface; other site
869209004524	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
869209004525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209004526	dimer interface [polypeptide binding]; other site
869209004527	conserved gate region; other site
869209004528	putative PBP binding loops; other site
869209004529	ABC-ATPase subunit interface; other site
869209004530	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
869209004531	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262
869209004532	Walker A/P-loop; other site
869209004533	ATP binding site [chemical binding]; other site
869209004534	Q-loop/lid; other site
869209004535	ABC transporter signature motif; other site
869209004536	Walker B; other site
869209004537	D-loop; other site
869209004538	H-loop/switch region; other site
869209004539	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
869209004540	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
869209004541	substrate binding pocket [chemical binding]; other site
869209004542	membrane-bound complex binding site; other site
869209004543	hinge residues; other site
869209004544	EamA-like transporter family; Region: EamA; cl01037
869209004545	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209004546	PilZ domain; Region: PilZ; cl01260
869209004547	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
869209004548	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
869209004549	PYR/PP interface [polypeptide binding]; other site
869209004550	dimer interface [polypeptide binding]; other site
869209004551	TPP binding site [chemical binding]; other site
869209004552	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
869209004553	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
869209004554	TPP-binding site [chemical binding]; other site
869209004555	dimer interface [polypeptide binding]; other site
869209004556	Dehydratase family; Region: ILVD_EDD; cl00340
869209004557	dihydroxy-acid dehydratase; Region: ilvD; TIGR00110
869209004558	UGMP family protein; Validated; Region: PRK09604
869209004559	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
869209004560	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
869209004561	Divergent polysaccharide deacetylase; Region: Polysacc_deac_2; cl04721
869209004562	ParB-like partition proteins; Region: parB_part; TIGR00180
869209004563	ParB-like nuclease domain; Region: ParBc; cl02129
869209004564	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
869209004565	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
869209004566	P-loop; other site
869209004567	Magnesium ion binding site [ion binding]; other site
869209004568	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
869209004569	Magnesium ion binding site [ion binding]; other site
869209004570	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
869209004571	MatE; Region: MatE; cl10513
869209004572	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
869209004573	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799
869209004574	active site
869209004575	substrate binding site [chemical binding]; other site
869209004576	metal binding site [ion binding]; metal-binding site
869209004577	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
869209004578	active site
869209004579	substrate binding site [chemical binding]; other site
869209004580	catalytic site [active]
869209004581	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
869209004582	MatE; Region: MatE; cl10513
869209004583	MatE; Region: MatE; cl10513
869209004584	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
869209004585	putative peptidoglycan binding site; other site
869209004586	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
869209004587	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
869209004588	putative peptidoglycan binding site; other site
869209004589	Peptidase family M23; Region: Peptidase_M23; pfam01551
869209004590	dihydrodipicolinate reductase; Provisional; Region: PRK00048
869209004591	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209004592	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
869209004593	aspartate kinase III; Validated; Region: PRK09084
869209004594	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
869209004595	nucleotide binding site [chemical binding]; other site
869209004596	substrate binding site [chemical binding]; other site
869209004597	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
869209004598	dimer interface [polypeptide binding]; other site
869209004599	allosteric regulatory binding pocket; other site
869209004600	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
869209004601	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
869209004602	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
869209004603	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
869209004604	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
869209004605	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
869209004606	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
869209004607	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
869209004608	PhoU domain; Region: PhoU; pfam01895
869209004609	NlpC/P60 family; Region: NLPC_P60; cl11438
869209004610	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
869209004611	Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821
869209004612	active site
869209004613	substrate-binding site [chemical binding]; other site
869209004614	metal-binding site [ion binding]
869209004615	GTP binding site [chemical binding]; other site
869209004616	elongation factor P; Validated; Region: PRK00529
869209004617	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
869209004618	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470
869209004619	RNA binding site [nucleotide binding]; other site
869209004620	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794
869209004621	RNA binding site [nucleotide binding]; other site
869209004622	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823
869209004623	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
869209004624	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209004625	DEAD-like helicases superfamily; Region: DEXDc; smart00487
869209004626	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869209004627	ATP binding site [chemical binding]; other site
869209004628	putative Mg++ binding site [ion binding]; other site
869209004629	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869209004630	nucleotide binding region [chemical binding]; other site
869209004631	ATP-binding site [chemical binding]; other site
869209004632	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
869209004633	HRDC domain; Region: HRDC; cl02578
869209004634	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
869209004635	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
869209004636	Queuine tRNA-ribosyltransferase; Region: TGT; cl00409
869209004637	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
869209004638	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
869209004639	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
869209004640	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
869209004641	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
869209004642	trimer interface [polypeptide binding]; other site
869209004643	active site
869209004644	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
869209004645	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
869209004646	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
869209004647	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
869209004648	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
869209004649	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
869209004650	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
869209004651	3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138
869209004652	3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725
869209004653	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
869209004654	putative nucleic acid binding region [nucleotide binding]; other site
869209004655	G-X-X-G motif; other site
869209004656	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472
869209004657	RNA binding site [nucleotide binding]; other site
869209004658	domain interface; other site
869209004659	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353
869209004660	16S/18S rRNA binding site [nucleotide binding]; other site
869209004661	S13e-L30e interaction site [polypeptide binding]; other site
869209004662	25S rRNA binding site [nucleotide binding]; other site
869209004663	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573
869209004664	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
869209004665	RNA binding site [nucleotide binding]; other site
869209004666	active site
869209004667	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
869209004668	active site
869209004669	Ribosome-binding factor A; Region: RBFA; cl00542
869209004670	translation initiation factor IF-2; Region: IF-2; TIGR00487
869209004671	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
869209004672	IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily.  IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits.  As seen in other GTPases...; Region: IF2_eIF5B; cd01887
869209004673	G1 box; other site
869209004674	putative GEF interaction site [polypeptide binding]; other site
869209004675	GTP/Mg2+ binding site [chemical binding]; other site
869209004676	Switch I region; other site
869209004677	G2 box; other site
869209004678	G3 box; other site
869209004679	Switch II region; other site
869209004680	G4 box; other site
869209004681	G5 box; other site
869209004682	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702
869209004683	Translation-initiation factor 2; Region: IF-2; pfam11987
869209004684	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692
869209004685	transcription termination factor NusA; Region: NusA; TIGR01953
869209004686	NusA N-terminal domain; Region: NusA_N; pfam08529
869209004687	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455
869209004688	RNA binding site [nucleotide binding]; other site
869209004689	homodimer interface [polypeptide binding]; other site
869209004690	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
869209004691	G-X-X-G motif; other site
869209004692	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members...; Region: Sm_like; cl00259
869209004693	Uncharacterised BCR, YhbC family COG0779; Region: DUF150; pfam02576
869209004694	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869209004695	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209004696	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209004697	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
869209004698	putative active site; other site
869209004699	putative metal binding residues [ion binding]; other site
869209004700	signature motif; other site
869209004701	putative triphosphate binding site [ion binding]; other site
869209004702	Protein of unknown function (DUF975); Region: DUF975; cl10504
869209004703	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
869209004704	tandem repeat interface [polypeptide binding]; other site
869209004705	oligomer interface [polypeptide binding]; other site
869209004706	active site residues [active]
869209004707	RecX family; Region: RecX; cl00936
869209004708	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
869209004709	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
869209004710	23S rRNA interface [nucleotide binding]; other site
869209004711	L3 interface [polypeptide binding]; other site
869209004712	Rubrerythrin [Energy production and conversion]; Region: COG1592
869209004713	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
869209004714	binuclear metal center [ion binding]; other site
869209004715	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and ferredoxin-...; Region: rubredoxin_SM; cd00729
869209004716	iron binding site [ion binding]; other site
869209004717	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
869209004718	AzlC protein; Region: AzlC; cl00570
869209004719	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
869209004720	PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D.  PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300
869209004721	Walker A/P-loop; other site
869209004722	ATP binding site [chemical binding]; other site
869209004723	Q-loop/lid; other site
869209004724	ABC transporter signature motif; other site
869209004725	Walker B; other site
869209004726	D-loop; other site
869209004727	H-loop/switch region; other site
869209004728	TOBE domain; Region: TOBE_2; cl01440
869209004729	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
869209004730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209004731	dimer interface [polypeptide binding]; other site
869209004732	conserved gate region; other site
869209004733	putative PBP binding loops; other site
869209004734	ABC-ATPase subunit interface; other site
869209004735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209004736	dimer interface [polypeptide binding]; other site
869209004737	conserved gate region; other site
869209004738	putative PBP binding loops; other site
869209004739	ABC-ATPase subunit interface; other site
869209004740	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
869209004741	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
869209004742	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
869209004743	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556
869209004744	hinge; other site
869209004745	active site
869209004746	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
869209004747	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852
869209004748	Mg++ binding site [ion binding]; other site
869209004749	putative catalytic motif [active]
869209004750	putative substrate binding site [chemical binding]; other site
869209004751	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
869209004752	Uncharacterized conserved protein [Function unknown]; Region: COG2006
869209004753	LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167
869209004754	putative metal binding site [ion binding]; other site
869209004755	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
869209004756	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
869209004757	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869209004758	homodimer interface [polypeptide binding]; other site
869209004759	catalytic residue [active]
869209004760	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
869209004761	Clp amino terminal domain; Region: Clp_N; pfam02861
869209004762	Clp amino terminal domain; Region: Clp_N; pfam02861
869209004763	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209004764	Walker A motif; other site
869209004765	ATP binding site [chemical binding]; other site
869209004766	Walker B motif; other site
869209004767	arginine finger; other site
869209004768	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209004769	Walker A motif; other site
869209004770	ATP binding site [chemical binding]; other site
869209004771	Walker B motif; other site
869209004772	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
869209004773	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
869209004774	Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823
869209004775	ADP binding site [chemical binding]; other site
869209004776	phosphagen binding site; other site
869209004777	substrate specificity loop; other site
869209004778	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
869209004779	UvrB/uvrC motif; Region: UVR; pfam02151
869209004780	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
869209004781	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
869209004782	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
869209004783	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
869209004784	Walker A/P-loop; other site
869209004785	ATP binding site [chemical binding]; other site
869209004786	Q-loop/lid; other site
869209004787	ABC transporter signature motif; other site
869209004788	Walker B; other site
869209004789	D-loop; other site
869209004790	H-loop/switch region; other site
869209004791	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
869209004792	FtsX-like permease family; Region: FtsX; pfam02687
869209004793	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
869209004794	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
869209004795	peptide chain release factor 2; Validated; Region: prfB; PRK00578
869209004796	RF-1 domain; Region: RF-1; cl02875
869209004797	RF-1 domain; Region: RF-1; cl02875
869209004798	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442
869209004799	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
869209004800	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
869209004801	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
869209004802	DNA binding site [nucleotide binding]
869209004803	active site
869209004804	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
869209004805	putative transporter; Provisional; Region: PRK11660
869209004806	Sulfate transporter family; Region: Sulfate_transp; cl00967
869209004807	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
869209004808	GTPase Era; Reviewed; Region: era; PRK00089
869209004809	Era subfamily.  Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria.  It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163
869209004810	G1 box; other site
869209004811	GTP/Mg2+ binding site [chemical binding]; other site
869209004812	Switch I region; other site
869209004813	G2 box; other site
869209004814	Switch II region; other site
869209004815	G3 box; other site
869209004816	G4 box; other site
869209004817	G5 box; other site
869209004818	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098
869209004819	GTP-binding protein YchF; Reviewed; Region: PRK09601
869209004820	YchF subfamily.  YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1.  Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900
869209004821	G1 box; other site
869209004822	GTP/Mg2+ binding site [chemical binding]; other site
869209004823	Switch I region; other site
869209004824	G2 box; other site
869209004825	Switch II region; other site
869209004826	G3 box; other site
869209004827	G4 box; other site
869209004828	G5 box; other site
869209004829	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
869209004830	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
869209004831	active site
869209004832	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
869209004833	dimer interface [polypeptide binding]; other site
869209004834	pyridoxal binding site [chemical binding]; other site
869209004835	ATP binding site [chemical binding]; other site
869209004836	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
869209004837	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
869209004838	DNA-binding site [nucleotide binding]; DNA binding site
869209004839	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
869209004840	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869209004841	homodimer interface [polypeptide binding]; other site
869209004842	catalytic residue [active]
869209004843	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
869209004844	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
869209004845	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
869209004846	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
869209004847	synthetase active site [active]
869209004848	NTP binding site [chemical binding]; other site
869209004849	metal binding site [ion binding]; metal-binding site
869209004850	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668
869209004851	Peptidase family U32; Region: Peptidase_U32; cl03113
869209004852	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
869209004853	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
869209004854	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
869209004855	proposed active site lysine [active]
869209004856	conserved cys residue [active]
869209004857	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209004858	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
869209004859	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
869209004860	multiple promoter invertase; Provisional; Region: mpi; PRK13413
869209004861	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
869209004862	catalytic residues [active]
869209004863	catalytic nucleophile [active]
869209004864	Presynaptic Site I dimer interface [polypeptide binding]; other site
869209004865	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
869209004866	Synaptic Flat tetramer interface [polypeptide binding]; other site
869209004867	Synaptic Site I dimer interface [polypeptide binding]; other site
869209004868	DNA binding site [nucleotide binding]
869209004869	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
869209004870	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
869209004871	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209004872	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107
869209004873	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
869209004874	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH_2; cd04602
869209004875	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381
869209004876	active site
869209004877	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
869209004878	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108
869209004879	GDP-binding site [chemical binding]; other site
869209004880	ACT binding site; other site
869209004881	IMP binding site; other site
869209004882	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
869209004883	MatE; Region: MatE; cl10513
869209004884	MatE; Region: MatE; cl10513
869209004885	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
869209004886	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
869209004887	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
869209004888	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
869209004889	N- and C-terminal domain interface [polypeptide binding]; other site
869209004890	active site
869209004891	MgATP binding site [chemical binding]; other site
869209004892	catalytic site [active]
869209004893	metal binding site [ion binding]; metal-binding site
869209004894	carbohydrate binding site [chemical binding]; other site
869209004895	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827
869209004896	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
869209004897	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
869209004898	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408
869209004899	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
869209004900	MatE; Region: MatE; cl10513
869209004901	MatE; Region: MatE; cl10513
869209004902	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
869209004903	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557
869209004904	homodimer interface [polypeptide binding]; other site
869209004905	substrate-cofactor binding pocket; other site
869209004906	catalytic residue [active]
869209004907	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
869209004908	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
869209004909	Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024
869209004910	Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384
869209004911	catalytic core domain of  class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674
869209004912	active site
869209004913	HIGH motif; other site
869209004914	KMSKS motif; other site
869209004915	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
869209004916	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2)...; Region: phosphohexomutase; cl03757
869209004917	active site
869209004918	substrate binding site [chemical binding]; other site
869209004919	metal binding site [ion binding]; metal-binding site
869209004920	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
869209004921	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
869209004922	motif II; other site
869209004923	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
869209004924	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209004925	Walker A motif; other site
869209004926	ATP binding site [chemical binding]; other site
869209004927	Walker B motif; other site
869209004928	arginine finger; other site
869209004929	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
869209004930	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
869209004931	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209004932	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
869209004933	ABC transporter; Region: ABC_tran_2; pfam12848
869209004934	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
869209004935	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784
869209004936	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869209004937	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209004938	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209004939	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
869209004940	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
869209004941	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
869209004942	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
869209004943	Domain of unknown function (DUF1887); Region: DUF1887; pfam09002
869209004944	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
869209004945	Divergent AAA domain; Region: AAA_4; pfam04326
869209004946	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
869209004947	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
869209004948	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
869209004949	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622
869209004950	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
869209004951	CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578
869209004952	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
869209004953	Beta-galactosidase; Region: Glyco_hydro_42; cl03154
869209004954	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
869209004955	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209004956	dimer interface [polypeptide binding]; other site
869209004957	conserved gate region; other site
869209004958	putative PBP binding loops; other site
869209004959	ABC-ATPase subunit interface; other site
869209004960	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209004961	dimer interface [polypeptide binding]; other site
869209004962	conserved gate region; other site
869209004963	putative PBP binding loops; other site
869209004964	ABC-ATPase subunit interface; other site
869209004965	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
869209004966	Transcriptional regulators [Transcription]; Region: PurR; COG1609
869209004967	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
869209004968	DNA binding site [nucleotide binding]
869209004969	domain linker motif; other site
869209004970	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
869209004971	dimerization interface [polypeptide binding]; other site
869209004972	ligand binding site [chemical binding]; other site
869209004973	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
869209004974	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
869209004975	active site
869209004976	intersubunit interface [polypeptide binding]; other site
869209004977	catalytic residue [active]
869209004978	glutamate dehydrogenase; Provisional; Region: PRK09414
869209004979	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
869209004980	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
869209004981	NAD(P) binding site [chemical binding]; other site
869209004982	Carbon starvation protein CstA; Region: CstA; cl00856
869209004983	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204
869209004984	6-phosphofructokinase; Provisional; Region: PRK03202
869209004985	active site
869209004986	ADP/pyrophosphate binding site [chemical binding]; other site
869209004987	dimerization interface [polypeptide binding]; other site
869209004988	allosteric effector site; other site
869209004989	fructose-1,6-bisphosphate binding site; other site
869209004990	LemA family; Region: LemA; cl00742
869209004991	Domain of unknown function (DUF477); Region: DUF477; cl01535
869209004992	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
869209004993	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209004994	active site
869209004995	phosphorylation site [posttranslational modification]
869209004996	intermolecular recognition site; other site
869209004997	dimerization interface [polypeptide binding]; other site
869209004998	CheB methylesterase; Region: CheB_methylest; pfam01339
869209004999	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
869209005000	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
869209005001	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209005002	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
869209005003	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
869209005004	putative peptidoglycan binding site; other site
869209005005	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
869209005006	putative peptidoglycan binding site; other site
869209005007	Peptidase family M23; Region: Peptidase_M23; pfam01551
869209005008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209005009	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
869209005010	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
869209005011	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
869209005012	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209005013	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
869209005014	DNA binding residues [nucleotide binding]
869209005015	GTP-binding protein Der; Reviewed; Region: PRK00093
869209005016	EngA1 subfamily.  This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894
869209005017	G1 box; other site
869209005018	GTP/Mg2+ binding site [chemical binding]; other site
869209005019	Switch I region; other site
869209005020	G2 box; other site
869209005021	Switch II region; other site
869209005022	G3 box; other site
869209005023	G4 box; other site
869209005024	G5 box; other site
869209005025	EngA2 subfamily.  This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895
869209005026	G1 box; other site
869209005027	GTP/Mg2+ binding site [chemical binding]; other site
869209005028	Switch I region; other site
869209005029	G2 box; other site
869209005030	G3 box; other site
869209005031	Switch II region; other site
869209005032	G4 box; other site
869209005033	G5 box; other site
869209005034	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
869209005035	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
869209005036	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
869209005037	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
869209005038	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
869209005039	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
869209005040	ligand binding site [chemical binding]; other site
869209005041	dimerization interface [polypeptide binding]; other site
869209005042	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
869209005043	metal binding site [ion binding]; metal-binding site
869209005044	active site
869209005045	I-site; other site
869209005046	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
869209005047	N-acetyl-D-glucosamine binding site [chemical binding]; other site
869209005048	catalytic residue [active]
869209005049	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
869209005050	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
869209005051	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412
869209005052	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
869209005053	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
869209005054	S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802
869209005055	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
869209005056	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
869209005057	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
869209005058	motif II; other site
869209005059	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
869209005060	oligomer interface [polypeptide binding]; other site
869209005061	putative active site [active]
869209005062	metal binding site [ion binding]; metal-binding site
869209005063	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
869209005064	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
869209005065	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
869209005066	substrate binding site [chemical binding]; other site
869209005067	dimer interface [polypeptide binding]; other site
869209005068	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554
869209005069	homotrimer interaction site [polypeptide binding]; other site
869209005070	zinc binding site [ion binding]; other site
869209005071	CDP-binding sites; other site
869209005072	RelB antitoxin; Region: RelB; cl01171
869209005073	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
869209005074	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209005075	non-specific DNA binding site [nucleotide binding]; other site
869209005076	salt bridge; other site
869209005077	sequence-specific DNA binding site [nucleotide binding]; other site
869209005078	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209005079	non-specific DNA binding site [nucleotide binding]; other site
869209005080	salt bridge; other site
869209005081	sequence-specific DNA binding site [nucleotide binding]; other site
869209005082	Domain of unknown function (DUF955); Region: DUF955; cl01076
869209005083	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209005084	non-specific DNA binding site [nucleotide binding]; other site
869209005085	salt bridge; other site
869209005086	sequence-specific DNA binding site [nucleotide binding]; other site
869209005087	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
869209005088	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
869209005089	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051
869209005090	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
869209005091	oligomeric interface; other site
869209005092	putative active site [active]
869209005093	homodimer interface [polypeptide binding]; other site
869209005094	Phd_YefM; Region: PhdYeFM; cl09153
869209005095	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
869209005096	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
869209005097	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
869209005098	Predicted membrane protein [Function unknown]; Region: COG4905
869209005099	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
869209005100	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
869209005101	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
869209005102	catalytic residue [active]
869209005103	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
869209005104	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209005105	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
869209005106	L-serine binding site [chemical binding]; other site
869209005107	ACT domain interface; other site
869209005108	C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156
869209005109	putative homotetramer interface [polypeptide binding]; other site
869209005110	putative homodimer interface [polypeptide binding]; other site
869209005111	putative allosteric switch controlling residues; other site
869209005112	putative metal binding site [ion binding]; other site
869209005113	putative homodimer-homodimer interface [polypeptide binding]; other site
869209005114	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
869209005115	metal-binding site [ion binding]
869209005116	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
869209005117	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
869209005118	metal-binding site [ion binding]
869209005119	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
869209005120	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
869209005121	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
869209005122	metal-binding site [ion binding]
869209005123	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
869209005124	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
869209005125	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
869209005126	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
869209005127	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
869209005128	ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614
869209005129	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869209005130	ATP binding site [chemical binding]; other site
869209005131	putative Mg++ binding site [ion binding]; other site
869209005132	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869209005133	nucleotide binding region [chemical binding]; other site
869209005134	ATP-binding site [chemical binding]; other site
869209005135	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
869209005136	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
869209005137	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
869209005138	active site
869209005139	phosphorylation site [posttranslational modification]
869209005140	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
869209005141	S-adenosylmethionine binding site [chemical binding]; other site
869209005142	DRTGG domain; Region: DRTGG; cl12147
869209005143	HPr kinase/phosphorylase; Provisional; Region: PRK05428
869209005144	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918
869209005145	Hpr binding site; other site
869209005146	active site
869209005147	homohexamer subunit interaction site [polypeptide binding]; other site
869209005148	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
869209005149	dimerization domain swap beta strand [polypeptide binding]; other site
869209005150	regulatory protein interface [polypeptide binding]; other site
869209005151	active site
869209005152	regulatory phosphorylation site [posttranslational modification]; other site
869209005153	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209005154	LexA repressor; Validated; Region: PRK00215
869209005155	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
869209005156	Catalytic site [active]
869209005157	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
869209005158	DNA polymerase III, delta subunit; Region: holA; TIGR01128
869209005159	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
869209005160	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
869209005161	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
869209005162	RNA binding surface [nucleotide binding]; other site
869209005163	PilZ domain; Region: PilZ; cl01260
869209005164	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209005165	TPR motif; other site
869209005166	binding surface
869209005167	Uncharacterized ACR, COG1430; Region: DUF192; cl00627
869209005168	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
869209005169	ligand binding site [chemical binding]; other site
869209005170	flexible hinge region; other site
869209005171	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
869209005172	ligand binding site [chemical binding]; other site
869209005173	flexible hinge region; other site
869209005174	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
869209005175	FAD binding domain; Region: FAD_binding_4; pfam01565
869209005176	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
869209005177	cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14536
869209005178	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
869209005179	active site
869209005180	HIGH motif; other site
869209005181	nucleotide binding site [chemical binding]; other site
869209005182	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
869209005183	KMSKS motif; other site
869209005184	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
869209005185	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
869209005186	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
869209005187	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
869209005188	DNA binding residues [nucleotide binding]
869209005189	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
869209005190	E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies.  These domains are associated with different types of catalytic domains at  either the N-terminal or C-terminal end; Region: E_set; cl09101
869209005191	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
869209005192	AAK_UMPK-PyrH-Pf: UMP kinase (UMPK)-Pf, the mostly archaeal uridine monophosphate kinase (uridylate kinase) enzymes that catalyze UMP phosphorylation and play a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back...; Region: AAK_UMPK-PyrH-Pf; cd04253
869209005193	nucleotide binding site [chemical binding]; other site
869209005194	homodimeric interface [polypeptide binding]; other site
869209005195	uridine monophosphate binding site [chemical binding]; other site
869209005196	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
869209005197	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
869209005198	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
869209005199	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
869209005200	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
869209005201	Bacitracin resistance protein BacA; Region: BacA; cl00858
869209005202	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
869209005203	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209005204	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209005205	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
869209005206	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
869209005207	Cation transport protein; Region: TrkH; cl10514
869209005208	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
869209005209	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
869209005210	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513
869209005211	FtsH protease regulator HflC; Provisional; Region: PRK11029
869209005212	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
869209005213	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
869209005214	HflK protein; Region: hflK; TIGR01933
869209005215	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209005216	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
869209005217	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
869209005218	trimer interface [polypeptide binding]; other site
869209005219	active site
869209005220	PSP1 C-terminal conserved region; Region: PSP1; cl00770
869209005221	Protein of unknown function (DUF327); Region: DUF327; cl00753
869209005222	Polymer-forming cytoskeletal; Region: Bactofilin; cl09137
869209005223	Peptidase family M23; Region: Peptidase_M23; pfam01551
869209005224	putative deoxyribonuclease YjjV; Provisional; Region: PRK11449
869209005225	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
869209005226	active site
869209005227	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
869209005228	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
869209005229	FMN binding site [chemical binding]; other site
869209005230	active site
869209005231	catalytic residues [active]
869209005232	substrate binding site [chemical binding]; other site
869209005233	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
869209005234	metal binding site [ion binding]; metal-binding site
869209005235	active site
869209005236	I-site; other site
869209005237	Rhomboid family; Region: Rhomboid; cl11446
869209005238	phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172
869209005239	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
869209005240	dimer interface [polypeptide binding]; other site
869209005241	motif 1; other site
869209005242	active site
869209005243	motif 2; other site
869209005244	motif 3; other site
869209005245	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209005246	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
869209005247	Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses.  These...; Region: TarH; cl00144
869209005248	DNA repair protein RadA; Provisional; Region: PRK11823
869209005249	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209005250	Walker A motif; other site
869209005251	ATP binding site [chemical binding]; other site
869209005252	Walker B motif; other site
869209005253	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
869209005254	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
869209005255	ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983
869209005256	Thymidylate synthase complementing protein; Region: Thy1; cl03630
869209005257	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
869209005258	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
869209005259	Transposase; Region: DEDD_Tnp_IS110; pfam01548
869209005260	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
869209005261	Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691
869209005262	HicB family; Region: HicB; pfam05534
869209005263	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
869209005264	Porin subfamily; Region: Porin_2; pfam02530
869209005265	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
869209005266	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
869209005267	Beta-Casp domain; Region: Beta-Casp; cl12567
869209005268	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
869209005269	SlyX; Region: SlyX; cl01090
869209005270	Haemolysin-III related; Region: HlyIII; cl03831
869209005271	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
869209005272	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
869209005273	TM-ABC transporter signature motif; other site
869209005274	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
869209005275	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
869209005276	Walker A/P-loop; other site
869209005277	ATP binding site [chemical binding]; other site
869209005278	Q-loop/lid; other site
869209005279	ABC transporter signature motif; other site
869209005280	Walker B; other site
869209005281	D-loop; other site
869209005282	H-loop/switch region; other site
869209005283	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
869209005284	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
869209005285	putative ligand binding site [chemical binding]; other site
869209005286	enolase; Provisional; Region: eno; PRK00077
869209005287	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
869209005288	dimer interface [polypeptide binding]; other site
869209005289	metal binding site [ion binding]; metal-binding site
869209005290	substrate binding pocket [chemical binding]; other site
869209005291	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
869209005292	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869209005293	homodimer interface [polypeptide binding]; other site
869209005294	catalytic residue [active]
869209005295	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
869209005296	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
869209005297	transmembrane helices; other site
869209005298	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
869209005299	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
869209005300	Walker A/P-loop; other site
869209005301	ATP binding site [chemical binding]; other site
869209005302	Q-loop/lid; other site
869209005303	ABC transporter signature motif; other site
869209005304	Walker B; other site
869209005305	D-loop; other site
869209005306	H-loop/switch region; other site
869209005307	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
869209005308	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
869209005309	Walker A/P-loop; other site
869209005310	ATP binding site [chemical binding]; other site
869209005311	Q-loop/lid; other site
869209005312	ABC transporter signature motif; other site
869209005313	Walker B; other site
869209005314	D-loop; other site
869209005315	H-loop/switch region; other site
869209005316	Cobalt transport protein; Region: CbiQ; cl00463
869209005317	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
869209005318	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
869209005319	active site
869209005320	metal binding site [ion binding]; metal-binding site
869209005321	homotetramer interface [polypeptide binding]; other site
869209005322	FecR protein; Region: FecR; pfam04773
869209005323	CHASE2 domain; Region: CHASE2; cl01732
869209005324	CHASE2 domain; Region: CHASE2; cl01732
869209005325	CHASE2 domain; Region: CHASE2; cl01732
869209005326	cyclase homology domain; Region: CHD; cd07302
869209005327	nucleotidyl binding site; other site
869209005328	metal binding site [ion binding]; metal-binding site
869209005329	dimer interface [polypeptide binding]; other site
869209005330	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
869209005331	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cd00578
869209005332	hexamer (dimer of trimers) interface [polypeptide binding]; other site
869209005333	substrate binding site [chemical binding]; other site
869209005334	trimer interface [polypeptide binding]; other site
869209005335	Mn binding site [ion binding]; other site
869209005336	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214
869209005337	intersubunit interface [polypeptide binding]; other site
869209005338	active site
869209005339	Zn2+ binding site [ion binding]; other site
869209005340	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
869209005341	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
869209005342	N- and C-terminal domain interface [polypeptide binding]; other site
869209005343	active site
869209005344	MgATP binding site [chemical binding]; other site
869209005345	catalytic site [active]
869209005346	metal binding site [ion binding]; metal-binding site
869209005347	carbohydrate binding site [chemical binding]; other site
869209005348	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
869209005349	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
869209005350	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216
869209005351	Walker A/P-loop; other site
869209005352	ATP binding site [chemical binding]; other site
869209005353	Q-loop/lid; other site
869209005354	ABC transporter signature motif; other site
869209005355	Walker B; other site
869209005356	D-loop; other site
869209005357	H-loop/switch region; other site
869209005358	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215
869209005359	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
869209005360	TM-ABC transporter signature motif; other site
869209005361	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
869209005362	TM-ABC transporter signature motif; other site
869209005363	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
869209005364	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
869209005365	flagellin; Provisional; Region: PRK12804
869209005366	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
869209005367	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
869209005368	Cupin domain; Region: Cupin_2; cl09118
869209005369	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
869209005370	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
869209005371	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
869209005372	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
869209005373	Flavoprotein; Region: Flavoprotein; cl08021
869209005374	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
869209005375	Mechanosensitive ion channel; Region: MS_channel; pfam00924
869209005376	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
869209005377	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
869209005378	peptide binding site [polypeptide binding]; other site
869209005379	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
869209005380	putative acyl-acceptor binding pocket; other site
869209005381	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
869209005382	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839
869209005383	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
869209005384	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
869209005385	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424
869209005386	dimer interface [polypeptide binding]; other site
869209005387	ADP-ribose binding site [chemical binding]; other site
869209005388	active site
869209005389	nudix motif; other site
869209005390	metal binding site [ion binding]; metal-binding site
869209005391	Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102
869209005392	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
869209005393	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714
869209005394	glutaminase active site [active]
869209005395	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
869209005396	dimer interface [polypeptide binding]; other site
869209005397	active site
869209005398	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
869209005399	dimer interface [polypeptide binding]; other site
869209005400	active site
869209005401	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
869209005402	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
869209005403	minor groove reading motif; other site
869209005404	helix-hairpin-helix signature motif; other site
869209005405	substrate binding pocket [chemical binding]; other site
869209005406	active site
869209005407	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
869209005408	S-adenosylmethionine synthetase; Validated; Region: PRK05250
869209005409	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
869209005410	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
869209005411	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
869209005412	E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies.  These domains are associated with different types of catalytic domains at  either the N-terminal or C-terminal end; Region: E_set; cl09101
869209005413	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
869209005414	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
869209005415	active site
869209005416	catalytic tetrad [active]
869209005417	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209005418	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
869209005419	Walker A/P-loop; other site
869209005420	ATP binding site [chemical binding]; other site
869209005421	Q-loop/lid; other site
869209005422	ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.  The...; Region: ABC_ATPase; cd00267
869209005423	ABC transporter signature motif; other site
869209005424	ABC transporter signature motif; other site
869209005425	Walker B; other site
869209005426	Walker B; other site
869209005427	D-loop; other site
869209005428	D-loop; other site
869209005429	H-loop/switch region; other site
869209005430	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209005431	Walker A/P-loop; other site
869209005432	ATP binding site [chemical binding]; other site
869209005433	Q-loop/lid; other site
869209005434	ABC transporter signature motif; other site
869209005435	Walker B; other site
869209005436	D-loop; other site
869209005437	H-loop/switch region; other site
869209005438	Transcriptional regulator [Transcription]; Region: LysR; COG0583
869209005439	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209005440	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
869209005441	dimerization interface [polypeptide binding]; other site
869209005442	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869209005443	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209005444	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209005445	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
869209005446	substrate binding pocket [chemical binding]; other site
869209005447	chain length determination region; other site
869209005448	substrate-Mg2+ binding site; other site
869209005449	catalytic residues [active]
869209005450	aspartate-rich region 1; other site
869209005451	active site lid residues [active]
869209005452	aspartate-rich region 2; other site
869209005453	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209005454	binding surface
869209005455	TPR motif; other site
869209005456	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209005457	TPR motif; other site
869209005458	binding surface
869209005459	OstA-like protein; Region: OstA; cl00844
869209005460	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
869209005461	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
869209005462	Walker A/P-loop; other site
869209005463	ATP binding site [chemical binding]; other site
869209005464	Q-loop/lid; other site
869209005465	ABC transporter signature motif; other site
869209005466	Walker B; other site
869209005467	D-loop; other site
869209005468	H-loop/switch region; other site
869209005469	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
869209005470	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
869209005471	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209005472	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
869209005473	putative catalytic site [active]
869209005474	putative metal binding site [ion binding]; other site
869209005475	putative phosphate binding site [ion binding]; other site
869209005476	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
869209005477	putative substrate translocation pore; other site
869209005478	Major Facilitator Superfamily; Region: MFS_1; pfam07690
869209005479	Radical SAM; Region: Elp3; smart00729
869209005480	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
869209005481	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
869209005482	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
869209005483	hypothetical protein; Provisional; Region: PRK01617
869209005484	SEC-C motif; Region: SEC-C; cl12132
869209005485	SEC-C motif; Region: SEC-C; cl12132
869209005486	Acyl-protein synthetase, LuxE; Region: LuxE; cl10450
869209005487	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
869209005488	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
869209005489	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
869209005490	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
869209005491	dimer interface [polypeptide binding]; other site
869209005492	PYR/PP interface [polypeptide binding]; other site
869209005493	TPP binding site [chemical binding]; other site
869209005494	substrate binding site [chemical binding]; other site
869209005495	TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the...; Region: TPP_IOR_alpha; cd02008
869209005496	TPP-binding site; other site
869209005497	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
869209005498	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
869209005499	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
869209005500	N-acetyl-D-glucosamine binding site [chemical binding]; other site
869209005501	catalytic residue [active]
869209005502	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
869209005503	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
869209005504	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC...; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
869209005505	NifU-like domain; Region: NifU; cl00484
869209005506	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
869209005507	shikimate kinase; Reviewed; Region: aroK; PRK00131
869209005508	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464
869209005509	ADP binding site [chemical binding]; other site
869209005510	magnesium binding site [ion binding]; other site
869209005511	putative shikimate binding site; other site
869209005512	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
869209005513	TraB family; Region: TraB; cl12050
869209005514	Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916
869209005515	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
869209005516	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209005517	binding surface
869209005518	TPR motif; other site
869209005519	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209005520	binding surface
869209005521	TPR motif; other site
869209005522	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209005523	binding surface
869209005524	TPR motif; other site
869209005525	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
869209005526	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
869209005527	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
869209005528	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
869209005529	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
869209005530	Polyphosphate kinase; Region: PP_kinase; pfam02503
869209005531	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
869209005532	putative domain interface [polypeptide binding]; other site
869209005533	putative active site [active]
869209005534	catalytic site [active]
869209005535	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
869209005536	putative domain interface [polypeptide binding]; other site
869209005537	putative active site [active]
869209005538	catalytic site [active]
869209005539	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
869209005540	rRNA binding site [nucleotide binding]; other site
869209005541	predicted 30S ribosome binding site; other site
869209005542	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
869209005543	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
869209005544	histidinol-phosphatase; Provisional; Region: PRK07328
869209005545	Response regulator receiver domain; Region: Response_reg; pfam00072
869209005546	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
869209005547	active site
869209005548	phosphorylation site [posttranslational modification]
869209005549	intermolecular recognition site; other site
869209005550	dimerization interface [polypeptide binding]; other site
869209005551	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
869209005552	conserved cys residue [active]
869209005553	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209005554	Flavin Reductases; Region: FlaRed; cl00801
869209005555	FOG: CBS domain [General function prediction only]; Region: COG0517
869209005556	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
869209005557	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
869209005558	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
869209005559	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
869209005560	Walker A/P-loop; other site
869209005561	ATP binding site [chemical binding]; other site
869209005562	Q-loop/lid; other site
869209005563	ABC transporter signature motif; other site
869209005564	Walker B; other site
869209005565	D-loop; other site
869209005566	H-loop/switch region; other site
869209005567	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
869209005568	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219
869209005569	Walker A/P-loop; other site
869209005570	ATP binding site [chemical binding]; other site
869209005571	Q-loop/lid; other site
869209005572	ABC transporter signature motif; other site
869209005573	Walker B; other site
869209005574	D-loop; other site
869209005575	H-loop/switch region; other site
869209005576	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
869209005577	TM-ABC transporter signature motif; other site
869209005578	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
869209005579	TM-ABC transporter signature motif; other site
869209005580	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
869209005581	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
869209005582	putative ligand binding site [chemical binding]; other site
869209005583	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
869209005584	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
869209005585	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
869209005586	alphaNTD homodimer interface [polypeptide binding]; other site
869209005587	alphaNTD - beta interaction site [polypeptide binding]; other site
869209005588	alphaNTD - beta' interaction site [polypeptide binding]; other site
869209005589	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
869209005590	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
869209005591	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
869209005592	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
869209005593	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
869209005594	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
869209005595	SecY translocase; Region: SecY; pfam00344
869209005596	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
869209005597	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658
869209005598	23S rRNA binding site [nucleotide binding]; other site
869209005599	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
869209005600	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
869209005601	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
869209005602	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
869209005603	5S rRNA interface [nucleotide binding]; other site
869209005604	23S rRNA interface [nucleotide binding]; other site
869209005605	L5 interface [polypeptide binding]; other site
869209005606	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
869209005607	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
869209005608	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
869209005609	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
869209005610	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
869209005611	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
869209005612	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
869209005613	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
869209005614	KOW motif; Region: KOW; cl00354
869209005615	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
869209005616	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
869209005617	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427
869209005618	putative translocon interaction site; other site
869209005619	signal recognition particle (SRP54) interaction site; other site
869209005620	L23 interface [polypeptide binding]; other site
869209005621	trigger factor interaction site; other site
869209005622	23S rRNA interface [nucleotide binding]; other site
869209005623	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
869209005624	23S rRNA interface [nucleotide binding]; other site
869209005625	5S rRNA interface [nucleotide binding]; other site
869209005626	putative antibiotic binding site [chemical binding]; other site
869209005627	L25 interface [polypeptide binding]; other site
869209005628	L27 interface [polypeptide binding]; other site
869209005629	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
869209005630	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The...; Region: 30S_S3_KH; cd02412
869209005631	G-X-X-G motif; other site
869209005632	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
869209005633	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
869209005634	protein-rRNA interface [nucleotide binding]; other site
869209005635	putative translocon binding site; other site
869209005636	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
869209005637	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
869209005638	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
869209005639	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
869209005640	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
869209005641	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
869209005642	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
869209005643	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
869209005644	elongation factor Tu; Reviewed; Region: PRK00049
869209005645	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
869209005646	G1 box; other site
869209005647	GEF interaction site [polypeptide binding]; other site
869209005648	GTP/Mg2+ binding site [chemical binding]; other site
869209005649	Switch I region; other site
869209005650	G2 box; other site
869209005651	G3 box; other site
869209005652	Switch II region; other site
869209005653	G4 box; other site
869209005654	G5 box; other site
869209005655	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
869209005656	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
869209005657	Antibiotic Binding Site [chemical binding]; other site
869209005658	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
869209005659	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
869209005660	S17 interaction site [polypeptide binding]; other site
869209005661	S8 interaction site; other site
869209005662	16S rRNA interaction site [nucleotide binding]; other site
869209005663	streptomycin interaction site [chemical binding]; other site
869209005664	23S rRNA interaction site [nucleotide binding]; other site
869209005665	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
869209005666	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
869209005667	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
869209005668	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
869209005669	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
869209005670	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Provisional; Region: PRK14844
869209005671	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
869209005672	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
869209005673	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
869209005674	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
869209005675	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
869209005676	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
869209005677	DNA binding site [nucleotide binding]
869209005678	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
869209005679	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
869209005680	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
869209005681	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591
869209005682	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
869209005683	RPB1 interaction site [polypeptide binding]; other site
869209005684	RPB10 interaction site [polypeptide binding]; other site
869209005685	RPB11 interaction site [polypeptide binding]; other site
869209005686	RPB3 interaction site [polypeptide binding]; other site
869209005687	RPB12 interaction site [polypeptide binding]; other site
869209005688	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
869209005689	core dimer interface [polypeptide binding]; other site
869209005690	peripheral dimer interface [polypeptide binding]; other site
869209005691	L10 interface [polypeptide binding]; other site
869209005692	L11 interface [polypeptide binding]; other site
869209005693	putative EF-Tu interaction site [polypeptide binding]; other site
869209005694	putative EF-G interaction site [polypeptide binding]; other site
869209005695	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797
869209005696	23S rRNA interface [nucleotide binding]; other site
869209005697	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
869209005698	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403
869209005699	mRNA/rRNA interface [nucleotide binding]; other site
869209005700	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
869209005701	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
869209005702	23S rRNA interface [nucleotide binding]; other site
869209005703	L7/L12 interface [polypeptide binding]; other site
869209005704	putative thiostrepton binding site; other site
869209005705	L25 interface [polypeptide binding]; other site
869209005706	transcription termination/antitermination factor NusG; Region: nusG; TIGR00922
869209005707	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
869209005708	putative homodimer interface [polypeptide binding]; other site
869209005709	KOW motif; Region: KOW; cl00354
869209005710	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
869209005711	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
869209005712	serine O-acetyltransferase; Region: cysE; TIGR01172
869209005713	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354
869209005714	trimer interface [polypeptide binding]; other site
869209005715	active site
869209005716	substrate binding site [chemical binding]; other site
869209005717	CoA binding site [chemical binding]; other site
869209005718	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
869209005719	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514
869209005720	Protein of unknown function (DUF497); Region: DUF497; cl01108
869209005721	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
869209005722	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556
869209005723	Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061
869209005724	Fic family protein [Function unknown]; Region: COG3177
869209005725	Fic/DOC family; Region: Fic; cl00960
869209005726	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
869209005727	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
869209005728	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
869209005729	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
869209005730	tellurite resistance protein TehB; Provisional; Region: PRK12335
869209005731	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
869209005732	S-adenosylmethionine binding site [chemical binding]; other site
869209005733	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
869209005734	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
869209005735	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
869209005736	phosphate binding site [ion binding]; other site
869209005737	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
869209005738	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
869209005739	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
869209005740	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281
869209005741	dihydroorotase; Validated; Region: pyrC; PRK09357
869209005742	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317
869209005743	active site
869209005744	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
869209005745	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
869209005746	metal binding site [ion binding]; metal-binding site
869209005747	active site
869209005748	I-site; other site
869209005749	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
869209005750	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
869209005751	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293
869209005752	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
869209005753	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine...; Region: URO-D_CIMS_like; cl00464
869209005754	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
869209005755	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
869209005756	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
869209005757	dimer interface [polypeptide binding]; other site
869209005758	anticodon binding site; other site
869209005759	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
869209005760	homodimer interface [polypeptide binding]; other site
869209005761	motif 1; other site
869209005762	active site
869209005763	motif 2; other site
869209005764	GAD domain; Region: GAD; pfam02938
869209005765	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
869209005766	active site
869209005767	motif 3; other site
869209005768	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
869209005769	Zn2+ binding site [ion binding]; other site
869209005770	Mg2+ binding site [ion binding]; other site
869209005771	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
869209005772	E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies.  These domains are associated with different types of catalytic domains at  either the N-terminal or C-terminal end; Region: E_set; cl09101
869209005773	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
869209005774	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
869209005775	Transcriptional regulators [Transcription]; Region: PurR; COG1609
869209005776	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
869209005777	DNA binding site [nucleotide binding]
869209005778	domain linker motif; other site
869209005779	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
869209005780	dimerization interface [polypeptide binding]; other site
869209005781	ligand binding site [chemical binding]; other site
869209005782	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209005783	dimer interface [polypeptide binding]; other site
869209005784	conserved gate region; other site
869209005785	putative PBP binding loops; other site
869209005786	ABC-ATPase subunit interface; other site
869209005787	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209005788	dimer interface [polypeptide binding]; other site
869209005789	conserved gate region; other site
869209005790	putative PBP binding loops; other site
869209005791	ABC-ATPase subunit interface; other site
869209005792	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
869209005793	Sodium:solute symporter family; Region: SSF; cl00456
869209005794	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
869209005795	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
869209005796	putative ligand binding site [chemical binding]; other site
869209005797	zinc binding site [ion binding]; other site
869209005798	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
869209005799	TM-ABC transporter signature motif; other site
869209005800	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
869209005801	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209005802	Walker A/P-loop; other site
869209005803	ATP binding site [chemical binding]; other site
869209005804	Q-loop/lid; other site
869209005805	ABC transporter signature motif; other site
869209005806	Walker B; other site
869209005807	D-loop; other site
869209005808	H-loop/switch region; other site
869209005809	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
869209005810	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
869209005811	Protein of unknown function (DUF763); Region: DUF763; cl00620
869209005812	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
869209005813	dimer interface [polypeptide binding]; other site
869209005814	conserved gate region; other site
869209005815	ABC-ATPase subunit interface; other site
869209005816	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
869209005817	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258
869209005818	Walker A/P-loop; other site
869209005819	ATP binding site [chemical binding]; other site
869209005820	Q-loop/lid; other site
869209005821	ABC transporter signature motif; other site
869209005822	Walker B; other site
869209005823	D-loop; other site
869209005824	H-loop/switch region; other site
869209005825	NIL domain; Region: NIL; cl09633
869209005826	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
869209005827	active site
869209005828	FMN-binding domain; Region: FMN_bind; cl01081
869209005829	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209005830	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
869209005831	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869209005832	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
869209005833	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
869209005834	active site
869209005835	dimer interface [polypeptide binding]; other site
869209005836	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
869209005837	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
869209005838	FAD binding pocket [chemical binding]; other site
869209005839	FAD binding motif [chemical binding]; other site
869209005840	phosphate binding motif [ion binding]; other site
869209005841	beta-alpha-beta structure motif; other site
869209005842	NAD binding pocket [chemical binding]; other site
869209005843	Iron coordination center [ion binding]; other site
869209005844	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
869209005845	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
869209005846	heterodimer interface [polypeptide binding]; other site
869209005847	active site
869209005848	FMN binding site [chemical binding]; other site
869209005849	homodimer interface [polypeptide binding]; other site
869209005850	substrate binding site [chemical binding]; other site
869209005851	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
869209005852	lipoprotein signal peptidase; Provisional; Region: PRK14787
869209005853	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
869209005854	active site
869209005855	metal binding site [ion binding]; metal-binding site
869209005856	homotetramer interface [polypeptide binding]; other site
869209005857	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
869209005858	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
869209005859	putative ADP-binding pocket [chemical binding]; other site
869209005860	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
869209005861	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
869209005862	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
869209005863	active site
869209005864	NAD binding site [chemical binding]; other site
869209005865	metal binding site [ion binding]; metal-binding site
869209005866	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
869209005867	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
869209005868	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209005869	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
869209005870	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
869209005871	active site
869209005872	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
869209005873	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
869209005874	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
869209005875	binding surface
869209005876	TPR motif; other site
869209005877	Restriction endonuclease; Region: Mrr_cat; cl00747
869209005878	hypothetical protein; Validated; Region: PRK07682
869209005879	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
869209005880	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869209005881	homodimer interface [polypeptide binding]; other site
869209005882	catalytic residue [active]
869209005883	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
869209005884	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
869209005885	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
869209005886	putative active site pocket [active]
869209005887	4-fold oligomerization interface [polypeptide binding]; other site
869209005888	metal binding residues [ion binding]; metal-binding site
869209005889	3-fold/trimer interface [polypeptide binding]; other site
869209005890	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
869209005891	ATP phosphoribosyltransferase; Region: HisG; cl15266
869209005892	HisG, C-terminal domain; Region: HisG_C; cl06867
869209005893	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
869209005894	tetramer (dimer of dimers) interface [polypeptide binding]; other site
869209005895	active site
869209005896	dimer interface [polypeptide binding]; other site
869209005897	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
869209005898	3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093
869209005899	active site
869209005900	catalytic residue [active]
869209005901	dimer interface [polypeptide binding]; other site
869209005902	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
869209005903	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
869209005904	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
869209005905	shikimate binding site; other site
869209005906	NAD(P) binding site [chemical binding]; other site
869209005907	DNA repair helicase rad25; Region: rad25; TIGR00603
869209005908	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209005909	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209005910	ATP binding site [chemical binding]; other site
869209005911	putative Mg++ binding site [ion binding]; other site
869209005912	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869209005913	nucleotide binding region [chemical binding]; other site
869209005914	ATP-binding site [chemical binding]; other site
869209005915	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and ferredoxin-...; Region: rubredoxin_SM; cd00729
869209005916	iron binding site [ion binding]; other site
869209005917	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
869209005918	diiron binding motif [ion binding]; other site
869209005919	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
869209005920	metal binding site 2 [ion binding]; metal-binding site
869209005921	putative DNA binding helix; other site
869209005922	metal binding site 1 [ion binding]; metal-binding site
869209005923	dimer interface [polypeptide binding]; other site
869209005924	structural Zn2+ binding site [ion binding]; other site
869209005925	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
869209005926	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
869209005927	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
869209005928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209005929	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869209005930	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209005931	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209005932	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
869209005933	additional DNA contacts [nucleotide binding]; other site
869209005934	mismatch recognition site; other site
869209005935	active site
869209005936	zinc binding site [ion binding]; other site
869209005937	DNA intercalation site [nucleotide binding]; other site
869209005938	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
869209005939	Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763
869209005940	Predicted periplasmic protein (DUF2271); Region: DUF2271; cl01469
869209005941	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
869209005942	YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094
869209005943	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895
869209005944	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
869209005945	active site
869209005946	catalytic residues [active]
869209005947	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
869209005948	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
869209005949	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
869209005950	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
869209005951	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869209005952	non-specific DNA binding site [nucleotide binding]; other site
869209005953	salt bridge; other site
869209005954	sequence-specific DNA binding site [nucleotide binding]; other site
869209005955	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
869209005956	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
869209005957	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
869209005958	RNA binding site [nucleotide binding]; other site
869209005959	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
869209005960	RNA binding site [nucleotide binding]; other site
869209005961	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
869209005962	RNA binding site [nucleotide binding]; other site
869209005963	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
869209005964	RNA binding site [nucleotide binding]; other site
869209005965	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
869209005966	putative active site [active]
869209005967	nucleotide binding site [chemical binding]; other site
869209005968	nudix motif; other site
869209005969	putative metal binding site [ion binding]; other site
869209005970	N-acetylglutamate synthase; Validated; Region: PRK05279
869209005971	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
869209005972	nucleotide binding site [chemical binding]; other site
869209005973	substrate binding site [chemical binding]; other site
869209005974	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
869209005975	DNA gyrase subunit A; Validated; Region: PRK05560
869209005976	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
869209005977	CAP-like domain; other site
869209005978	Active site [active]
869209005979	primary dimer interface [polypeptide binding]; other site
869209005980	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
869209005981	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
869209005982	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
869209005983	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
869209005984	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
869209005985	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
869209005986	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
869209005987	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869209005988	ATP binding site [chemical binding]; other site
869209005989	Mg2+ binding site [ion binding]; other site
869209005990	G-X-G motif; other site
869209005991	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
869209005992	anchoring element; other site
869209005993	dimer interface [polypeptide binding]; other site
869209005994	ATP binding site [chemical binding]; other site
869209005995	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366
869209005996	active site
869209005997	putative metal-binding site [ion binding]; other site
869209005998	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
869209005999	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
869209006000	Baseplate J-like protein; Region: Baseplate_J; cl01294
869209006001	Baseplate J-like protein; Region: Baseplate_J; cl01294
869209006002	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
869209006003	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125
869209006004	Protein of unknown function (DUF1257); Region: DUF1257; cl06088
869209006005	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
869209006006	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
869209006007	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
869209006008	Peptidase family M23; Region: Peptidase_M23; pfam01551
869209006009	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
869209006010	putative transposase OrfB; Reviewed; Region: PHA02517
869209006011	Integrase core domain; Region: rve; cl01316
869209006012	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
869209006013	Peptidase family M23; Region: Peptidase_M23; pfam01551
869209006014	Domain of unknown function (DUF955); Region: DUF955; cl01076
869209006015	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
869209006016	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
869209006017	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
869209006018	metal ion-dependent adhesion site (MIDAS); other site
869209006019	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
869209006020	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125
869209006021	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
869209006022	Phage protein D [General function prediction only]; Region: COG3500; cl12180
869209006023	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
869209006024	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl01000
869209006025	Protein of unknown function (DUF1442); Region: DUF1442; pfam07279
869209006026	Protein of unknown function (DUF3289); Region: DUF3289; cl11840
869209006027	putative transposase OrfB; Reviewed; Region: PHA02517
869209006028	Integrase core domain; Region: rve; cl01316
869209006029	Phage protein D [General function prediction only]; Region: COG3500; cl12180
869209006030	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
869209006031	Phage protein D [General function prediction only]; Region: COG3500; cl12180
869209006032	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
869209006033	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl01000
869209006034	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222
869209006035	putative transposase OrfB; Reviewed; Region: PHA02517
869209006036	Integrase core domain; Region: rve; cl01316
869209006037	Phage protein D [General function prediction only]; Region: COG3500; cl12180
869209006038	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
869209006039	Phage protein D [General function prediction only]; Region: COG3500; cl12180
869209006040	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259
869209006041	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
869209006042	Ycf46; Provisional; Region: ycf46; CHL00195
869209006043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
869209006044	Walker A motif; other site
869209006045	ATP binding site [chemical binding]; other site
869209006046	Walker B motif; other site
869209006047	arginine finger; other site
869209006048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
869209006049	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
869209006050	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
869209006051	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
869209006052	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
869209006053	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
869209006054	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
869209006055	Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432
869209006056	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
869209006057	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
869209006058	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
869209006059	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869209006060	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209006061	Transposase [DNA replication, recombination, and repair]; Region: COG5433
869209006062	putative transposase OrfB; Reviewed; Region: PHA02517
869209006063	Integrase core domain; Region: rve; cl01316
869209006064	putative transposase OrfB; Reviewed; Region: PHA02517
869209006065	Integrase core domain; Region: rve; cl01316
869209006066	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
869209006067	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
869209006068	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
869209006069	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
869209006070	VirB7 interaction site; other site
869209006071	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
869209006072	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
869209006073	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362
869209006074	active site
869209006075	putative interdomain interaction site [polypeptide binding]; other site
869209006076	putative metal-binding site [ion binding]; other site
869209006077	putative nucleotide binding site [chemical binding]; other site
869209006078	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
869209006079	domain I; other site
869209006080	DNA binding groove [nucleotide binding]
869209006081	phosphate binding site [ion binding]; other site
869209006082	domain II; other site
869209006083	domain III; other site
869209006084	nucleotide binding site [chemical binding]; other site
869209006085	catalytic site [active]
869209006086	domain IV; other site
869209006087	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529
869209006088	Catalytic site [active]
869209006089	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
869209006090	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
869209006091	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
869209006092	conjugal transfer coupling protein TraG; Provisional; Region: PRK13880
869209006093	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209006094	Walker A motif; other site
869209006095	ATP binding site [chemical binding]; other site
869209006096	Walker B motif; other site
869209006097	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
869209006098	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209006099	Walker A motif; other site
869209006100	ATP binding site [chemical binding]; other site
869209006101	Walker B motif; other site
869209006102	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
869209006103	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
869209006104	VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
869209006105	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
869209006106	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
869209006107	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
869209006108	generic binding surface II; other site
869209006109	generic binding surface I; other site
869209006110	ParB-like nuclease domain; Region: ParBc; cl02129
869209006111	ParB-like partition proteins; Region: parB_part; TIGR00180
869209006112	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
869209006113	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
869209006114	Magnesium ion binding site [ion binding]; other site
869209006115	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
869209006116	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
869209006117	P-loop; other site
869209006118	Magnesium ion binding site [ion binding]; other site
869209006119	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
869209006120	Magnesium ion binding site [ion binding]; other site
869209006121	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
869209006122	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
869209006123	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
869209006124	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
869209006125	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209006126	ATP binding site [chemical binding]; other site
869209006127	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209006128	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
869209006129	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
869209006130	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401