-- dump date 20111121_015502 -- class Genbank::misc_feature -- table misc_feature_note -- id note 203124000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 203124000002 hypothetical protein; Validated; Region: PRK06672 203124000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124000004 Walker A motif; other site 203124000005 ATP binding site [chemical binding]; other site 203124000006 Walker B motif; other site 203124000007 arginine finger; other site 203124000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 203124000009 DnaA box-binding interface [nucleotide binding]; other site 203124000010 Integrase core domain; Region: rve; cl01316 203124000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cl02940 203124000012 beta-clamp/translesion DNA polymerase binding surface; other site 203124000013 beta-clamp/clamp loader binding surface; other site 203124000014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124000015 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 203124000016 Oxyanion-translocating ATPase (ArsA). This ATPase is involved in transport of arsenite, antimonite or other oxyanions across biological membranes in all three kingdoms of life. ArsA contains a highly conserved AAA motif present in the AAA+ ATPase...; Region: ArsA_ATPase; cd00550 203124000017 ATP binding site [chemical binding]; other site 203124000018 dimerization interface [polypeptide binding]; other site 203124000019 Metal binding site [ion binding]; metal-binding site 203124000020 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 203124000021 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 203124000022 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124000023 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 203124000024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 203124000025 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 203124000026 Dehydratase family; Region: ILVD_EDD; cl00340 203124000027 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 203124000028 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124000029 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 203124000030 phosphopeptide binding site; other site 203124000031 Transglycosylase; Region: Transgly; cl07896 203124000032 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 203124000033 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 203124000034 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000035 binding surface 203124000036 TPR motif; other site 203124000037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000038 binding surface 203124000039 TPR motif; other site 203124000040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000041 binding surface 203124000042 TPR motif; other site 203124000043 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124000044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124000045 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 203124000046 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 203124000047 active site 203124000048 interdomain interaction site; other site 203124000049 putative metal-binding site [ion binding]; other site 203124000050 nucleotide binding site [chemical binding]; other site 203124000051 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986 203124000052 domain I; other site 203124000053 phosphate binding site [ion binding]; other site 203124000054 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 203124000055 domain II; other site 203124000056 domain III; other site 203124000057 nucleotide binding site [chemical binding]; other site 203124000058 DNA binding groove [nucleotide binding] 203124000059 catalytic site [active] 203124000060 domain IV; other site 203124000061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124000062 Domain of unknown function (DUF477); Region: DUF477; cl01535 203124000063 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 203124000064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124000065 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 203124000066 Protein of unknown function (DUF760); Region: DUF760; pfam05542 203124000067 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 203124000068 heterotetramer interface [polypeptide binding]; other site 203124000069 active site pocket [active] 203124000070 cleavage site 203124000071 Uncharacterized conserved protein [Function unknown]; Region: COG1543 203124000072 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 203124000073 CHAT domain; Region: CHAT; cl02083 203124000074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124000075 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 203124000076 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124000077 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 203124000078 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124000079 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124000080 Protein kinase domain; Region: Pkinase; pfam00069 203124000081 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124000082 active site 203124000083 ATP binding site [chemical binding]; other site 203124000084 substrate binding site [chemical binding]; other site 203124000085 activation loop (A-loop); other site 203124000086 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124000087 structural tetrad; other site 203124000088 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 203124000089 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 203124000090 Moco binding site; other site 203124000091 metal coordination site [ion binding]; other site 203124000092 multifunctional aminopeptidase A; Provisional; Region: PRK00913 203124000093 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 203124000094 interface (dimer of trimers) [polypeptide binding]; other site 203124000095 Substrate-binding/catalytic site; other site 203124000096 Zn-binding sites [ion binding]; other site 203124000097 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 203124000098 isocitrate dehydrogenase; Validated; Region: PRK07362 203124000099 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124000100 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 203124000101 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 203124000102 putative lipid kinase; Reviewed; Region: PRK13057 203124000103 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 203124000104 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 203124000105 sulfotransferase; Region: PLN02164 203124000106 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124000107 aspartate kinase; Provisional; Region: PRK07431 203124000108 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 203124000109 putative nucleotide binding site [chemical binding]; other site 203124000110 putative catalytic residues [active] 203124000111 putative Mg ion binding site [ion binding]; other site 203124000112 putative aspartate binding site [chemical binding]; other site 203124000113 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 203124000114 putative allosteric regulatory site; other site 203124000115 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 203124000116 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 203124000117 putative allosteric regulatory site; other site 203124000118 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 203124000119 putative allosteric regulatory residue; other site 203124000120 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 203124000121 phosphopeptide binding site; other site 203124000122 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124000123 active site 203124000124 ATP binding site [chemical binding]; other site 203124000125 substrate binding site [chemical binding]; other site 203124000126 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124000127 activation loop (A-loop); other site 203124000128 probable methyltransferase; Region: TIGR03438 203124000129 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 203124000130 TIGR03440 family protein; Region: unchr_TIGR03440 203124000131 DinB superfamily; Region: DinB_2; cl00986 203124000132 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124000133 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 203124000134 Domain of unknown function (DUF427); Region: DUF427; cl00998 203124000135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124000136 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 203124000137 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 203124000138 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 203124000139 active site 203124000140 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124000141 Calx-beta domain; Region: Calx-beta; cl02522 203124000142 Calx-beta domain; Region: Calx-beta; cl02522 203124000143 Pirin-related protein [General function prediction only]; Region: COG1741 203124000144 Cupin domain; Region: Cupin_2; cl09118 203124000145 Vitamin K epoxide reductase family; Region: VKOR; cl01729 203124000146 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 203124000147 ATP adenylyltransferase; Region: ATP_transf; pfam09830 203124000148 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 203124000149 short chain dehydrogenase; Provisional; Region: PRK06197 203124000150 putative NAD(P) binding site [chemical binding]; other site 203124000151 active site 203124000152 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 203124000153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000154 binding surface 203124000155 TPR motif; other site 203124000156 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 203124000157 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000158 binding surface 203124000159 TPR motif; other site 203124000160 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 203124000161 Probable Catalytic site [active] 203124000162 metal binding site [ion binding]; metal-binding site 203124000163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124000164 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124000165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000166 binding surface 203124000167 TPR motif; other site 203124000168 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000169 binding surface 203124000170 TPR motif; other site 203124000171 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 203124000172 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 203124000173 putative active site [active] 203124000174 catalytic triad [active] 203124000175 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 203124000176 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 203124000177 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 203124000178 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124000179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124000180 S-adenosylmethionine binding site [chemical binding]; other site 203124000181 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 203124000182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000183 TPR motif; other site 203124000184 binding surface 203124000185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000186 binding surface 203124000187 TPR motif; other site 203124000188 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism]; Region: COG4421 203124000189 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 203124000190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000191 binding surface 203124000192 TPR motif; other site 203124000193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000194 binding surface 203124000195 TPR motif; other site 203124000196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000197 binding surface 203124000198 TPR motif; other site 203124000199 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000200 binding surface 203124000201 TPR motif; other site 203124000202 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124000203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000204 binding surface 203124000205 TPR motif; other site 203124000206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000207 binding surface 203124000208 TPR motif; other site 203124000209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000210 binding surface 203124000211 TPR motif; other site 203124000212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000213 binding surface 203124000214 TPR motif; other site 203124000215 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 203124000216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000217 binding surface 203124000218 TPR motif; other site 203124000219 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124000220 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124000221 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 203124000222 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 203124000223 Walker A/P-loop; other site 203124000224 ATP binding site [chemical binding]; other site 203124000225 Q-loop/lid; other site 203124000226 ABC transporter signature motif; other site 203124000227 Walker B; other site 203124000228 D-loop; other site 203124000229 H-loop/switch region; other site 203124000230 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 203124000231 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 203124000232 Walker A/P-loop; other site 203124000233 ATP binding site [chemical binding]; other site 203124000234 Q-loop/lid; other site 203124000235 ABC transporter signature motif; other site 203124000236 Walker B; other site 203124000237 D-loop; other site 203124000238 H-loop/switch region; other site 203124000239 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 203124000240 TM-ABC transporter signature motif; other site 203124000241 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 203124000242 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 203124000243 TM-ABC transporter signature motif; other site 203124000244 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 203124000245 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 203124000246 putative ligand binding site [chemical binding]; other site 203124000247 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 203124000248 putative active site [active] 203124000249 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 203124000250 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 203124000251 Uncharacterised BCR, COG1649; Region: DUF187; pfam02638 203124000252 Protein of unknown function DUF262; Region: DUF262; cl14890 203124000253 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124000254 Uncharacterized conserved protein [Function unknown]; Region: COG4938 203124000255 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 203124000256 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 203124000257 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 203124000258 threonine synthase; Reviewed; Region: PRK06721 203124000259 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 203124000260 homodimer interface [polypeptide binding]; other site 203124000261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124000262 catalytic residue [active] 203124000263 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 203124000264 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 203124000265 putative di-iron ligands [ion binding]; other site 203124000266 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 203124000267 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 203124000268 P-loop; other site 203124000269 Magnesium ion binding site [ion binding]; other site 203124000270 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 203124000271 Magnesium ion binding site [ion binding]; other site 203124000272 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 203124000273 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 203124000274 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 203124000275 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124000276 active site 203124000277 transcription termination factor Rho; Provisional; Region: rho; PRK09376 203124000278 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 203124000279 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 203124000280 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 203124000281 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 203124000282 substrate binding pocket [chemical binding]; other site 203124000283 chain length determination region; other site 203124000284 substrate-Mg2+ binding site; other site 203124000285 catalytic residues [active] 203124000286 aspartate-rich region 1; other site 203124000287 active site lid residues [active] 203124000288 aspartate-rich region 2; other site 203124000289 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 203124000290 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 203124000291 catalytic triad [active] 203124000292 dimer interface [polypeptide binding]; other site 203124000293 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 203124000294 active site 203124000295 dimer interface [polypeptide binding]; other site 203124000296 PsbP; Region: PsbP; cl03356 203124000297 RuvA N terminal domain; Region: RuvA_N; pfam01330 203124000298 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 203124000299 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 203124000300 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 203124000301 16S/18S rRNA binding site [nucleotide binding]; other site 203124000302 S13e-L30e interaction site [polypeptide binding]; other site 203124000303 25S rRNA binding site [nucleotide binding]; other site 203124000304 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 203124000305 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 203124000306 NeuB family; Region: NeuB; cl00496 203124000307 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 203124000308 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 203124000309 FeS/SAM binding site; other site 203124000310 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 203124000311 GUN4-like; Region: GUN4; pfam05419 203124000312 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124000313 GUN4-like; Region: GUN4; pfam05419 203124000314 Transposase IS200 like; Region: Y1_Tnp; cl00848 203124000315 Cytochrome P450; Region: p450; cl12078 203124000316 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 203124000317 protein I interface; other site 203124000318 D2 interface; other site 203124000319 protein T interface; other site 203124000320 chlorophyll binding site; other site 203124000321 beta carotene binding site; other site 203124000322 pheophytin binding site; other site 203124000323 manganese-stabilizing polypeptide interface; other site 203124000324 CP43 interface; other site 203124000325 protein L interface; other site 203124000326 oxygen evolving complex binding site; other site 203124000327 bromide binding site; other site 203124000328 quinone binding site; other site 203124000329 Fe binding site [ion binding]; other site 203124000330 core light harvesting interface; other site 203124000331 cytochrome b559 alpha subunit interface; other site 203124000332 cytochrome c-550 interface; other site 203124000333 protein J interface; other site 203124000334 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 203124000335 protein I interface; other site 203124000336 D2 interface; other site 203124000337 protein T interface; other site 203124000338 chlorophyll binding site; other site 203124000339 beta carotene binding site; other site 203124000340 pheophytin binding site; other site 203124000341 manganese-stabilizing polypeptide interface; other site 203124000342 CP43 interface; other site 203124000343 protein L interface; other site 203124000344 oxygen evolving complex binding site; other site 203124000345 bromide binding site; other site 203124000346 quinone binding site; other site 203124000347 Fe binding site [ion binding]; other site 203124000348 core light harvesting interface; other site 203124000349 cytochrome b559 alpha subunit interface; other site 203124000350 cytochrome c-550 interface; other site 203124000351 protein J interface; other site 203124000352 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124000353 active site 203124000354 ATP binding site [chemical binding]; other site 203124000355 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124000356 substrate binding site [chemical binding]; other site 203124000357 activation loop (A-loop); other site 203124000358 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124000359 structural tetrad; other site 203124000360 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 203124000361 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 203124000362 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 203124000363 catalytic residue [active] 203124000364 TM0106 family; Region: TIGR03491 203124000365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 203124000366 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 203124000367 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 203124000368 HIGH motif; other site 203124000369 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 203124000370 active site 203124000371 KMSKS motif; other site 203124000372 photosystem I P subunit (PSI-P); Region: PLN02777 203124000373 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 203124000374 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 203124000375 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 203124000376 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 203124000377 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 203124000378 Walker A/P-loop; other site 203124000379 ATP binding site [chemical binding]; other site 203124000380 Q-loop/lid; other site 203124000381 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 203124000382 ABC transporter signature motif; other site 203124000383 Walker B; other site 203124000384 D-loop; other site 203124000385 H-loop/switch region; other site 203124000386 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 203124000387 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 203124000388 Walker A/P-loop; other site 203124000389 ATP binding site [chemical binding]; other site 203124000390 Q-loop/lid; other site 203124000391 ABC transporter signature motif; other site 203124000392 Walker B; other site 203124000393 D-loop; other site 203124000394 H-loop/switch region; other site 203124000395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124000396 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 203124000397 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 203124000398 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 203124000399 catalytic residue [active] 203124000400 Predicted transcriptional regulator [Transcription]; Region: COG2345 203124000401 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 203124000402 sensory histidine kinase AtoS; Provisional; Region: PRK11360 203124000403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124000404 dimer interface [polypeptide binding]; other site 203124000405 phosphorylation site [posttranslational modification] 203124000406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124000407 ATP binding site [chemical binding]; other site 203124000408 Mg2+ binding site [ion binding]; other site 203124000409 G-X-G motif; other site 203124000410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124000411 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 203124000412 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 203124000413 putative NAD(P) binding site [chemical binding]; other site 203124000414 homodimer interface [polypeptide binding]; other site 203124000415 homotetramer interface [polypeptide binding]; other site 203124000416 active site 203124000417 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 203124000418 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 203124000419 active site 203124000420 homodimer interface [polypeptide binding]; other site 203124000421 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124000422 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 203124000423 Mechanosensitive ion channel; Region: MS_channel; pfam00924 203124000424 Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the...; Region: DEP; cd04371 203124000425 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 203124000426 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 203124000427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124000428 DNA polymerase III subunit delta; Validated; Region: PRK07452 203124000429 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 203124000430 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 203124000431 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 203124000432 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 203124000433 Creatinine amidohydrolase; Region: Creatininase; cl00618 203124000434 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 203124000435 homodimer interface [polypeptide binding]; other site 203124000436 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 203124000437 active site pocket [active] 203124000438 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 203124000439 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 203124000440 FeS/SAM binding site; other site 203124000441 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 203124000442 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 203124000443 active site 203124000444 ATP binding site [chemical binding]; other site 203124000445 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 203124000446 PPIC-type PPIASE domain; Region: Rotamase; cl08278 203124000447 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 203124000448 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 203124000449 ligand binding site [chemical binding]; other site 203124000450 flexible hinge region; other site 203124000451 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 203124000452 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 203124000453 putative active site [active] 203124000454 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 203124000455 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124000456 Walker A/P-loop; other site 203124000457 ATP binding site [chemical binding]; other site 203124000458 Q-loop/lid; other site 203124000459 ABC transporter signature motif; other site 203124000460 Walker B; other site 203124000461 D-loop; other site 203124000462 H-loop/switch region; other site 203124000463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124000464 CHASE2 domain; Region: CHASE2; cl01732 203124000465 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 203124000466 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 203124000467 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 203124000468 UbiA prenyltransferase family; Region: UbiA; cl00337 203124000469 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 203124000470 putative catalytic residues [active] 203124000471 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 203124000472 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 203124000473 dimer interface [polypeptide binding]; other site 203124000474 decamer (pentamer of dimers) interface [polypeptide binding]; other site 203124000475 catalytic triad [active] 203124000476 peroxidatic and resolving cysteines [active] 203124000477 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 203124000478 putative peptidoglycan binding site; other site 203124000479 Peptidase family M23; Region: Peptidase_M23; pfam01551 203124000480 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 203124000481 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124000482 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 203124000483 putative active site [active] 203124000484 putative NTP binding site [chemical binding]; other site 203124000485 putative nucleic acid binding site [nucleotide binding]; other site 203124000486 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 203124000487 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 203124000488 active site 203124000489 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124000490 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 203124000491 putative active site [active] 203124000492 putative NTP binding site [chemical binding]; other site 203124000493 putative nucleic acid binding site [nucleotide binding]; other site 203124000494 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 203124000495 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 203124000496 active site 203124000497 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 203124000498 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 203124000499 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124000500 active site 203124000501 ATP binding site [chemical binding]; other site 203124000502 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124000503 substrate binding site [chemical binding]; other site 203124000504 activation loop (A-loop); other site 203124000505 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124000506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124000507 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 203124000508 THUMP domain; Region: THUMP; cl12076 203124000509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124000510 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 203124000511 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 203124000512 putative peptidoglycan binding site; other site 203124000513 Peptidase family M23; Region: Peptidase_M23; pfam01551 203124000514 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792 203124000515 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 203124000516 active site 203124000517 dimer interface [polypeptide binding]; other site 203124000518 catalytic nucleophile [active] 203124000519 Endodeoxyribonuclease RusA; Region: RusA; cl01885 203124000520 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 203124000521 L11 interface [polypeptide binding]; other site 203124000522 putative EF-Tu interaction site [polypeptide binding]; other site 203124000523 putative EF-G interaction site [polypeptide binding]; other site 203124000524 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 203124000525 23S rRNA interface [nucleotide binding]; other site 203124000526 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 203124000527 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 203124000528 mRNA/rRNA interface [nucleotide binding]; other site 203124000529 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 203124000530 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 203124000531 23S rRNA interface [nucleotide binding]; other site 203124000532 L7/L12 interface [polypeptide binding]; other site 203124000533 putative thiostrepton binding site; other site 203124000534 L25 interface [polypeptide binding]; other site 203124000535 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 203124000536 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 203124000537 putative homodimer interface [polypeptide binding]; other site 203124000538 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 203124000539 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 203124000540 EamA-like transporter family; Region: EamA; cl01037 203124000541 EamA-like transporter family; Region: EamA; cl01037 203124000542 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 203124000543 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 203124000544 ring oligomerisation interface [polypeptide binding]; other site 203124000545 ATP/Mg binding site [chemical binding]; other site 203124000546 stacking interactions; other site 203124000547 hinge regions; other site 203124000548 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 203124000549 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124000550 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124000551 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124000552 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124000553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203124000554 putative substrate translocation pore; other site 203124000555 Major Facilitator Superfamily; Region: MFS_1; pfam07690 203124000556 sulfotransferase; Region: PLN02164 203124000557 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124000558 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 203124000559 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 203124000560 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 203124000561 Subunit I/III interface [polypeptide binding]; other site 203124000562 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 203124000563 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily...; Region: Heme_Cu_Oxidase_I; cl00275 203124000564 D-pathway; other site 203124000565 Low-spin heme binding site [chemical binding]; other site 203124000566 Putative water exit pathway; other site 203124000567 Binuclear center (active site) [active] 203124000568 K-pathway; other site 203124000569 Putative proton exit pathway; other site 203124000570 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 203124000571 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 203124000572 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 203124000573 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 203124000574 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 203124000575 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 203124000576 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 203124000577 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 203124000578 active site 203124000579 dimer interface [polypeptide binding]; other site 203124000580 catalytic residue [active] 203124000581 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051 203124000582 Ca2+ binding site [ion binding]; other site 203124000583 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 203124000584 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 203124000585 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 203124000586 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 203124000587 active site 203124000588 catalytic residues [active] 203124000589 metal binding site [ion binding]; metal-binding site 203124000590 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 203124000591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124000592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124000593 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124000594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000595 binding surface 203124000596 TPR motif; other site 203124000597 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 203124000598 aspartate aminotransferase; Provisional; Region: PRK08361 203124000599 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 203124000600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124000601 homodimer interface [polypeptide binding]; other site 203124000602 catalytic residue [active] 203124000603 Protein of unknown function DUF89; Region: DUF89; cl00680 203124000604 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 203124000605 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 203124000606 Zn binding site [ion binding]; other site 203124000607 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 203124000608 DNA binding residues [nucleotide binding] 203124000609 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 203124000610 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 203124000611 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 203124000612 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124000613 Walker A/P-loop; other site 203124000614 ATP binding site [chemical binding]; other site 203124000615 Q-loop/lid; other site 203124000616 ABC transporter signature motif; other site 203124000617 Walker B; other site 203124000618 D-loop; other site 203124000619 H-loop/switch region; other site 203124000620 ABC transporter; Region: ABC_tran_2; pfam12848 203124000621 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 203124000622 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 203124000623 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 203124000624 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 203124000625 active site 203124000626 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 203124000627 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 203124000628 Flavin Reductases; Region: FlaRed; cl00801 203124000629 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 203124000630 MG2 domain; Region: A2M_N; pfam01835 203124000631 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 203124000632 Alpha-2-macroglobulin family; Region: A2M; pfam00207 203124000633 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 203124000634 surface patch; other site 203124000635 specificity defining residues; other site 203124000636 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 203124000637 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 203124000638 FeS/SAM binding site; other site 203124000639 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 203124000640 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 203124000641 ligand binding site [chemical binding]; other site 203124000642 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins...; Region: Band_7_flotillin; cd03399 203124000643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 203124000644 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 203124000645 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins...; Region: Band_7_flotillin; cd03399 203124000646 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 203124000647 TIGR03032 family protein; Region: TIGR03032 203124000648 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 203124000649 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 203124000650 active site 203124000651 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 203124000652 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 203124000653 active site 203124000654 (T/H)XGH motif; other site 203124000655 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 203124000656 nudix motif; other site 203124000657 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 203124000658 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 203124000659 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 203124000660 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 203124000661 RNA binding surface [nucleotide binding]; other site 203124000662 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 203124000663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124000664 S-adenosylmethionine binding site [chemical binding]; other site 203124000665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124000666 S-adenosylmethionine binding site [chemical binding]; other site 203124000667 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 203124000668 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 203124000669 N-terminal domain interface [polypeptide binding]; other site 203124000670 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 203124000671 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 203124000672 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 203124000673 nucleoside transporter; Region: nupC; TIGR00804 203124000674 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 203124000675 Nucleoside recognition; Region: Gate; cl00486 203124000676 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 203124000677 GTP-binding protein Der; Reviewed; Region: PRK00093 203124000678 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 203124000679 G1 box; other site 203124000680 GTP/Mg2+ binding site [chemical binding]; other site 203124000681 Switch I region; other site 203124000682 G2 box; other site 203124000683 Switch II region; other site 203124000684 G3 box; other site 203124000685 G4 box; other site 203124000686 G5 box; other site 203124000687 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 203124000688 G1 box; other site 203124000689 GTP/Mg2+ binding site [chemical binding]; other site 203124000690 Switch I region; other site 203124000691 G2 box; other site 203124000692 G3 box; other site 203124000693 Switch II region; other site 203124000694 G4 box; other site 203124000695 G5 box; other site 203124000696 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 203124000697 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 203124000698 heme binding pocket [chemical binding]; other site 203124000699 heme ligand [chemical binding]; other site 203124000700 Uncharacterised BCR, COG1649; Region: DUF187; pfam02638 203124000701 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 203124000702 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 203124000703 active site 203124000704 metal binding site [ion binding]; metal-binding site 203124000705 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 203124000706 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 203124000707 putative active site [active] 203124000708 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 203124000709 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 203124000710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 203124000711 Family of unknown function (DUF490); Region: DUF490; pfam04357 203124000712 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 203124000713 Acyl transferase domain; Region: Acyl_transf_1; cl08282 203124000714 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 203124000715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 203124000716 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 203124000717 Probable transposase; Region: OrfB_IS605; pfam01385 203124000718 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 203124000719 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 203124000720 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 203124000721 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 203124000722 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cd00741 203124000723 nucleophilic elbow; other site 203124000724 catalytic triad; other site 203124000725 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 203124000726 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 203124000727 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 203124000728 catalytic residue [active] 203124000729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124000730 S-adenosylmethionine binding site [chemical binding]; other site 203124000731 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 203124000732 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 203124000733 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 203124000734 C-terminal domain interface [polypeptide binding]; other site 203124000735 GSH binding site (G-site) [chemical binding]; other site 203124000736 dimer interface [polypeptide binding]; other site 203124000737 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 203124000738 N-terminal domain interface [polypeptide binding]; other site 203124000739 Phycobilisome protein; Region: Phycobilisome; cl08227 203124000740 Multicopper oxidase; Region: Cu-oxidase; cl14658 203124000741 Multicopper oxidase; Region: Cu-oxidase; cl14658 203124000742 Multicopper oxidase; Region: Cu-oxidase; cl14658 203124000743 Protein of unknown function, DUF; Region: DUF411; cl01142 203124000744 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 203124000745 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 203124000746 CoA-binding site [chemical binding]; other site 203124000747 ATP-binding [chemical binding]; other site 203124000748 haemagglutination activity domain; Region: Haemagg_act; cl05436 203124000749 cell division protein ZipA; Provisional; Region: PRK01741 203124000750 CHAT domain; Region: CHAT; cl02083 203124000751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124000752 S-adenosylmethionine binding site [chemical binding]; other site 203124000753 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 203124000754 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 203124000755 Walker A/P-loop; other site 203124000756 ATP binding site [chemical binding]; other site 203124000757 Q-loop/lid; other site 203124000758 ABC transporter signature motif; other site 203124000759 Walker B; other site 203124000760 D-loop; other site 203124000761 H-loop/switch region; other site 203124000762 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124000763 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 203124000764 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 203124000765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124000766 dimer interface [polypeptide binding]; other site 203124000767 conserved gate region; other site 203124000768 ABC-ATPase subunit interface; other site 203124000769 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 203124000770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124000771 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 203124000772 EamA-like transporter family; Region: EamA; cl01037 203124000773 EamA-like transporter family; Region: EamA; cl01037 203124000774 Domain of Unknown Function with PDB structure; Region: DUF3862; pfam12978 203124000775 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 203124000776 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 203124000777 active site 203124000778 dimer interface [polypeptide binding]; other site 203124000779 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 203124000780 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 203124000781 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 203124000782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 203124000783 FeS/SAM binding site; other site 203124000784 TRAM domain; Region: TRAM; cl01282 203124000785 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 203124000786 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 203124000787 Surface antigen; Region: Bac_surface_Ag; cl03097 203124000788 haemagglutination activity domain; Region: Haemagg_act; cl05436 203124000789 CHAT domain; Region: CHAT; cl02083 203124000790 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 203124000791 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 203124000792 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 203124000793 CHASE2 domain; Region: CHASE2; cl01732 203124000794 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124000795 structural tetrad; other site 203124000796 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 203124000797 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 203124000798 DNA binding residues [nucleotide binding] 203124000799 Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium; plays a role in cell...; Region: CA; cl02468 203124000800 Ca2+ binding site [ion binding]; other site 203124000801 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124000802 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124000803 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 203124000804 catalytic residues [active] 203124000805 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 203124000806 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 203124000807 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 203124000808 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 203124000809 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 203124000810 Phage Tail Collar Domain; Region: Collar; pfam07484 203124000811 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 203124000812 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 203124000813 NAD binding site [chemical binding]; other site 203124000814 substrate binding site [chemical binding]; other site 203124000815 active site 203124000816 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124000817 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 203124000818 GAF domain; Region: GAF; cl00853 203124000819 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124000820 GAF domain; Region: GAF; cl00853 203124000821 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 203124000822 cyclase homology domain; Region: CHD; cd07302 203124000823 nucleotidyl binding site; other site 203124000824 metal binding site [ion binding]; metal-binding site 203124000825 dimer interface [polypeptide binding]; other site 203124000826 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124000827 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124000828 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124000829 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124000830 methionine aminopeptidase; Reviewed; Region: PRK07281 203124000831 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 203124000832 active site 203124000833 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 203124000834 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 203124000835 putative molybdopterin cofactor binding site [chemical binding]; other site 203124000836 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787 203124000837 putative molybdopterin cofactor binding site; other site 203124000838 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124000839 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124000840 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 203124000841 Staphylococcal nuclease homologues; Region: SNc; smart00318 203124000842 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 203124000843 Catalytic site; other site 203124000844 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 203124000845 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 203124000846 motif II; other site 203124000847 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 203124000848 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 203124000849 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 203124000850 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 203124000851 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 203124000852 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 203124000853 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 203124000854 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 203124000855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124000856 binding surface 203124000857 TPR motif; other site 203124000858 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 203124000859 active site 203124000860 putative substrate binding region [chemical binding]; other site 203124000861 CHRD domain; Region: CHRD; cl06473 203124000862 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 203124000863 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124000864 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 203124000865 active site 203124000866 metal binding site [ion binding]; metal-binding site 203124000867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 203124000868 CHRD domain; Region: CHRD; cl06473 203124000869 CHRD domain; Region: CHRD; cl06473 203124000870 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 203124000871 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124000872 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 203124000873 thioester formation/cholesterol transfer; other site 203124000874 protein-splicing catalytic site; other site 203124000875 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 203124000876 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl09966 203124000877 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 203124000878 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08332 203124000879 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 203124000880 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl09966 203124000881 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 203124000882 thioester formation/cholesterol transfer; other site 203124000883 protein-splicing catalytic site; other site 203124000884 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08332 203124000885 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 203124000886 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08332 203124000887 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 203124000888 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 203124000889 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 203124000890 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124000891 putative active site [active] 203124000892 putative NTP binding site [chemical binding]; other site 203124000893 putative nucleic acid binding site [nucleotide binding]; other site 203124000894 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 203124000895 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 203124000896 active site 203124000897 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 203124000898 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124000899 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 203124000900 putative active site [active] 203124000901 putative NTP binding site [chemical binding]; other site 203124000902 putative nucleic acid binding site [nucleotide binding]; other site 203124000903 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 203124000904 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 203124000905 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 203124000906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124000907 dimer interface [polypeptide binding]; other site 203124000908 conserved gate region; other site 203124000909 putative PBP binding loops; other site 203124000910 ABC-ATPase subunit interface; other site 203124000911 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 203124000912 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 203124000913 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 203124000914 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 203124000915 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 203124000916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124000917 Integrase core domain; Region: rve; cl01316 203124000918 Cupin domain; Region: Cupin_2; cl09118 203124000919 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 203124000920 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124000921 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 203124000922 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 203124000923 putative active site [active] 203124000924 dimerization interface [polypeptide binding]; other site 203124000925 putative tRNAtyr binding site [nucleotide binding]; other site 203124000926 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 203124000927 Transglycosylase; Region: Transgly; cl07896 203124000928 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 203124000929 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 203124000930 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 203124000931 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 203124000932 active site 203124000933 HIGH motif; other site 203124000934 dimer interface [polypeptide binding]; other site 203124000935 KMSKS motif; other site 203124000936 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 203124000937 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 203124000938 active site 203124000939 dimer interface [polypeptide binding]; other site 203124000940 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 203124000941 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 203124000942 active site 203124000943 catalytic triad [active] 203124000944 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 203124000945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124000946 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 203124000947 Walker A motif; other site 203124000948 ATP binding site [chemical binding]; other site 203124000949 Walker B motif; other site 203124000950 arginine finger; other site 203124000951 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 203124000952 transketolase; Region: PLN02790 203124000953 TPP-binding site [chemical binding]; other site 203124000954 dimer interface [polypeptide binding]; other site 203124000955 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 203124000956 PYR/PP interface [polypeptide binding]; other site 203124000957 dimer interface [polypeptide binding]; other site 203124000958 TPP binding site [chemical binding]; other site 203124000959 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 203124000960 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 203124000961 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 203124000962 dimer interface [polypeptide binding]; other site 203124000963 active site 203124000964 Phosphopantetheine attachment site; Region: PP-binding; cl09936 203124000965 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 203124000966 Cysteine-rich domain; Region: CCG; pfam02754 203124000967 Cysteine-rich domain; Region: CCG; pfam02754 203124000968 photosystem I subunit VII; Region: psaC; CHL00065 203124000969 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 203124000970 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 203124000971 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 203124000972 glutaminase active site [active] 203124000973 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 203124000974 dimer interface [polypeptide binding]; other site 203124000975 active site 203124000976 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 203124000977 dimer interface [polypeptide binding]; other site 203124000978 active site 203124000979 Uncharacterized conserved protein [Function unknown]; Region: COG4279 203124000980 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 203124000981 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 203124000982 active site 203124000983 catalytic tetrad [active] 203124000984 PUCC protein; Region: PUCC; pfam03209 203124000985 Protein kinase domain; Region: Pkinase; pfam00069 203124000986 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124000987 active site 203124000988 ATP binding site [chemical binding]; other site 203124000989 substrate binding site [chemical binding]; other site 203124000990 activation loop (A-loop); other site 203124000991 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124000992 Protein kinase domain; Region: Pkinase; pfam00069 203124000993 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124000994 active site 203124000995 ATP binding site [chemical binding]; other site 203124000996 substrate binding site [chemical binding]; other site 203124000997 activation loop (A-loop); other site 203124000998 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124000999 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 203124001000 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124001001 active site 203124001002 ATP binding site [chemical binding]; other site 203124001003 substrate binding site [chemical binding]; other site 203124001004 activation loop (A-loop); other site 203124001005 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124001006 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124001007 active site 203124001008 ATP binding site [chemical binding]; other site 203124001009 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124001010 substrate binding site [chemical binding]; other site 203124001011 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 203124001012 substrate binding site [chemical binding]; other site 203124001013 activation loop (A-loop); other site 203124001014 activation loop (A-loop); other site 203124001015 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124001016 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 203124001017 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 203124001018 DNA binding residues [nucleotide binding] 203124001019 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 203124001020 catalytic residues [active] 203124001021 catalytic nucleophile [active] 203124001022 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 203124001023 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 203124001024 active site 203124001025 dimer interface [polypeptide binding]; other site 203124001026 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 203124001027 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 203124001028 active site 203124001029 FMN binding site [chemical binding]; other site 203124001030 substrate binding site [chemical binding]; other site 203124001031 3Fe-4S cluster binding site [ion binding]; other site 203124001032 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 203124001033 domain interface; other site 203124001034 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 203124001035 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 203124001036 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124001037 putative active site [active] 203124001038 putative NTP binding site [chemical binding]; other site 203124001039 putative nucleic acid binding site [nucleotide binding]; other site 203124001040 Cupin domain; Region: Cupin_2; cl09118 203124001041 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 203124001042 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 203124001043 S17 interaction site [polypeptide binding]; other site 203124001044 S8 interaction site; other site 203124001045 16S rRNA interaction site [nucleotide binding]; other site 203124001046 streptomycin interaction site [chemical binding]; other site 203124001047 23S rRNA interaction site [nucleotide binding]; other site 203124001048 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 203124001049 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 203124001050 elongation factor G; Reviewed; Region: PRK00007 203124001051 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 203124001052 G1 box; other site 203124001053 putative GEF interaction site [polypeptide binding]; other site 203124001054 GTP/Mg2+ binding site [chemical binding]; other site 203124001055 Switch I region; other site 203124001056 G2 box; other site 203124001057 G3 box; other site 203124001058 Switch II region; other site 203124001059 G4 box; other site 203124001060 G5 box; other site 203124001061 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 203124001062 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 203124001063 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 203124001064 elongation factor Tu; Region: tufA; CHL00071 203124001065 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 203124001066 G1 box; other site 203124001067 GEF interaction site [polypeptide binding]; other site 203124001068 GTP/Mg2+ binding site [chemical binding]; other site 203124001069 Switch I region; other site 203124001070 G2 box; other site 203124001071 G3 box; other site 203124001072 Switch II region; other site 203124001073 G4 box; other site 203124001074 G5 box; other site 203124001075 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 203124001076 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 203124001077 Antibiotic Binding Site [chemical binding]; other site 203124001078 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 203124001079 Found in ATP-dependent protease La (LON); Region: LON; cl01056 203124001080 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 203124001081 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 203124001082 prephenate dehydratase; Provisional; Region: PRK11898 203124001083 Prephenate dehydratase; Region: PDT; pfam00800 203124001084 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 203124001085 putative L-Phe binding site [chemical binding]; other site 203124001086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001087 binding surface 203124001088 TPR motif; other site 203124001089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001090 binding surface 203124001091 TPR motif; other site 203124001092 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 203124001093 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124001094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001095 binding surface 203124001096 TPR motif; other site 203124001097 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 203124001098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001099 binding surface 203124001100 TPR motif; other site 203124001101 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 203124001102 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124001103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001104 TPR motif; other site 203124001105 binding surface 203124001106 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124001107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001108 binding surface 203124001109 TPR motif; other site 203124001110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001111 binding surface 203124001112 TPR motif; other site 203124001113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001114 binding surface 203124001115 TPR motif; other site 203124001116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001117 binding surface 203124001118 TPR motif; other site 203124001119 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124001120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001121 TPR motif; other site 203124001122 binding surface 203124001123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001124 binding surface 203124001125 TPR motif; other site 203124001126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001127 binding surface 203124001128 TPR motif; other site 203124001129 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 203124001130 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124001131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001132 binding surface 203124001133 TPR motif; other site 203124001134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001135 TPR motif; other site 203124001136 binding surface 203124001137 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 203124001138 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124001139 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124001140 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 203124001141 RNA/DNA hybrid binding site [nucleotide binding]; other site 203124001142 active site 203124001143 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 203124001144 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 203124001145 homodimer interface [polypeptide binding]; other site 203124001146 oligonucleotide binding site [chemical binding]; other site 203124001147 Probable transposase; Region: OrfB_IS605; pfam01385 203124001148 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 203124001149 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 203124001150 B12 binding site [chemical binding]; other site 203124001151 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 203124001152 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 203124001153 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 203124001154 aspartate aminotransferase; Provisional; Region: PRK07681 203124001155 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 203124001156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124001157 homodimer interface [polypeptide binding]; other site 203124001158 catalytic residue [active] 203124001159 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124001160 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124001161 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 203124001162 putative active site [active] 203124001163 catalytic triad [active] 203124001164 Bacterial sugar transferase; Region: Bac_transf; cl00939 203124001165 GDP-mannose 4,6-dehydratase; Region: PLN02653 203124001166 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 203124001167 NADP-binding site; other site 203124001168 homotetramer interface [polypeptide binding]; other site 203124001169 substrate binding site [chemical binding]; other site 203124001170 homodimer interface [polypeptide binding]; other site 203124001171 active site 203124001172 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 203124001173 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 203124001174 NADP binding site [chemical binding]; other site 203124001175 active site 203124001176 putative substrate binding site [chemical binding]; other site 203124001177 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 203124001178 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 203124001179 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 203124001180 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 203124001181 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 203124001182 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 203124001183 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 203124001184 G1 box; other site 203124001185 GTP/Mg2+ binding site [chemical binding]; other site 203124001186 Switch I region; other site 203124001187 G2 box; other site 203124001188 Switch II region; other site 203124001189 G3 box; other site 203124001190 G4 box; other site 203124001191 G5 box; other site 203124001192 Domain of unknown function (DUF697); Region: DUF697; cl12064 203124001193 Conserved TM helix; Region: TM_helix; pfam05552 203124001194 Conserved TM helix; Region: TM_helix; pfam05552 203124001195 Conserved TM helix; Region: TM_helix; pfam05552 203124001196 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 203124001197 hydrophobic ligand binding site; other site 203124001198 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 203124001199 Uncharacterized conserved protein [Function unknown]; Region: COG2912 203124001200 hypothetical protein; Provisional; Region: PRK10941 203124001201 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 203124001202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 203124001203 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 203124001204 ATP binding site [chemical binding]; other site 203124001205 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 203124001206 Protein of unknown function DUF124; Region: DUF124; cl00884 203124001207 Protein of unknown function DUF124; Region: DUF124; cl00884 203124001208 Protein of unknown function DUF124; Region: DUF124; cl00884 203124001209 Peptidase family M48; Region: Peptidase_M48; cl12018 203124001210 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 203124001211 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 203124001212 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 203124001213 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 203124001214 dimer interface [polypeptide binding]; other site 203124001215 active site 203124001216 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 203124001217 active site 203124001218 Ycf4; Region: Ycf4; cl03567 203124001219 Photosystem II protein; Region: PSII; cl08223 203124001220 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 203124001221 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 203124001222 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 203124001223 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124001224 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 203124001225 catalytic triad [active] 203124001226 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 203124001227 active site 203124001228 intersubunit interactions; other site 203124001229 catalytic residue [active] 203124001230 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124001231 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124001232 putative cation:proton antiport protein; Provisional; Region: PRK10669 203124001233 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 203124001234 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 203124001235 putative metal binding site [ion binding]; other site 203124001236 XisI protein; Region: XisI; pfam08869 203124001237 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 203124001238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001239 binding surface 203124001240 TPR motif; other site 203124001241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001242 binding surface 203124001243 TPR motif; other site 203124001244 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 203124001245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001246 binding surface 203124001247 TPR motif; other site 203124001248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001249 binding surface 203124001250 TPR motif; other site 203124001251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001252 binding surface 203124001253 TPR motif; other site 203124001254 CHAT domain; Region: CHAT; cl02083 203124001255 Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains...; Region: Peptidase_M14-like_6; cd06233 203124001256 putative active site [active] 203124001257 Zn-binding site [ion binding]; other site 203124001258 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 203124001259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124001260 cofactor binding site; other site 203124001261 DNA binding site [nucleotide binding] 203124001262 substrate interaction site [chemical binding]; other site 203124001263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124001264 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 203124001265 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 203124001266 phosphopeptide binding site; other site 203124001267 Double zinc ribbon; Region: DZR; pfam12773 203124001268 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 203124001269 phosphopeptide binding site; other site 203124001270 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 203124001271 putative active site [active] 203124001272 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 203124001273 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 203124001274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124001275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 203124001276 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 203124001277 Clp amino terminal domain; Region: Clp_N; pfam02861 203124001278 Clp amino terminal domain; Region: Clp_N; pfam02861 203124001279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124001280 Walker A motif; other site 203124001281 ATP binding site [chemical binding]; other site 203124001282 Walker B motif; other site 203124001283 arginine finger; other site 203124001284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124001285 Walker A motif; other site 203124001286 ATP binding site [chemical binding]; other site 203124001287 Walker B motif; other site 203124001288 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 203124001289 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 203124001290 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 203124001291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124001292 dimer interface [polypeptide binding]; other site 203124001293 phosphorylation site [posttranslational modification] 203124001294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124001295 ATP binding site [chemical binding]; other site 203124001296 Mg2+ binding site [ion binding]; other site 203124001297 G-X-G motif; other site 203124001298 DNA polymerase I; Provisional; Region: PRK05755 203124001299 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 203124001300 active site 203124001301 metal binding site 1 [ion binding]; metal-binding site 203124001302 putative 5' ssDNA interaction site; other site 203124001303 metal binding site 3; metal-binding site 203124001304 metal binding site 2 [ion binding]; metal-binding site 203124001305 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 203124001306 putative DNA binding site [nucleotide binding]; other site 203124001307 putative metal binding site [ion binding]; other site 203124001308 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 203124001309 active site 203124001310 catalytic site [active] 203124001311 substrate binding site [chemical binding]; other site 203124001312 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 203124001313 active site 203124001314 DNA binding site [nucleotide binding] 203124001315 catalytic site [active] 203124001316 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 203124001317 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 203124001318 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 203124001319 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 203124001320 MBOAT family; Region: MBOAT; cl00738 203124001321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001322 TPR motif; other site 203124001323 binding surface 203124001324 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 203124001325 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 203124001326 active site residue [active] 203124001327 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 203124001328 active site residue [active] 203124001329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124001330 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 203124001331 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 203124001332 Substrate binding site [chemical binding]; other site 203124001333 Mg++ binding site [ion binding]; other site 203124001334 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 203124001335 active site 203124001336 substrate binding site [chemical binding]; other site 203124001337 CoA binding site [chemical binding]; other site 203124001338 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 203124001339 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 203124001340 putative NAD(P) binding site [chemical binding]; other site 203124001341 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 203124001342 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 203124001343 putative NAD(P) binding site [chemical binding]; other site 203124001344 substrate binding site [chemical binding]; other site 203124001345 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 203124001346 putative active site [active] 203124001347 Sodium:solute symporter family; Region: SSF; cl00456 203124001348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001349 binding surface 203124001350 TPR motif; other site 203124001351 haemagglutination activity domain; Region: Haemagg_act; cl05436 203124001352 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 203124001353 Ring-infected erythrocyte surface antigen; Provisional; Region: PTZ00341 203124001354 CHAT domain; Region: CHAT; cl02083 203124001355 haemagglutination activity domain; Region: Haemagg_act; cl05436 203124001356 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 203124001357 Ring-infected erythrocyte surface antigen; Provisional; Region: PTZ00341 203124001358 CHAT domain; Region: CHAT; cl02083 203124001359 haemagglutination activity domain; Region: Haemagg_act; cl05436 203124001360 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 203124001361 CHAT domain; Region: CHAT; cl02083 203124001362 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124001363 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 203124001364 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 203124001365 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 203124001366 [2Fe-2S] cluster binding site [ion binding]; other site 203124001367 histidyl-tRNA synthetase; Region: hisS; TIGR00442 203124001368 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 203124001369 dimer interface [polypeptide binding]; other site 203124001370 motif 1; other site 203124001371 motif 2; other site 203124001372 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 203124001373 active site 203124001374 motif 3; other site 203124001375 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 203124001376 anticodon binding site; other site 203124001377 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 203124001378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124001379 HisG, C-terminal domain; Region: HisG_C; cl06867 203124001380 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 203124001381 secreted effector protein PipB; Provisional; Region: PRK15197 203124001382 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124001383 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124001384 tryptophan synthase, beta chain; Region: PLN02618 203124001385 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 203124001386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124001387 catalytic residue [active] 203124001388 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 203124001389 Beta-lactamase; Region: Beta-lactamase; cl01009 203124001390 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 203124001391 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 203124001392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124001393 Walker A motif; other site 203124001394 ATP binding site [chemical binding]; other site 203124001395 Walker B motif; other site 203124001396 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 203124001397 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 203124001398 oligomer interface [polypeptide binding]; other site 203124001399 active site residues [active] 203124001400 trigger factor; Provisional; Region: tig; PRK01490 203124001401 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 203124001402 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 203124001403 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 203124001404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124001405 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 203124001406 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 203124001407 dihydrodipicolinate synthase; Region: dapA; TIGR00674 203124001408 dimer interface [polypeptide binding]; other site 203124001409 active site 203124001410 catalytic residue [active] 203124001411 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 203124001412 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 203124001413 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 203124001414 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124001415 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 203124001416 proposed catalytic triad [active] 203124001417 active site nucleophile [active] 203124001418 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 203124001419 GatB domain; Region: GatB_Yqey; cl11497 203124001420 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 203124001421 ribose-phosphate pyrophosphokinase; Region: PLN02369 203124001422 Protein of unknown function DUF262; Region: DUF262; cl14890 203124001423 Protein of unknown function DUF262; Region: DUF262; cl14890 203124001424 Calx-beta domain; Region: Calx-beta; cl02522 203124001425 Calx-beta domain; Region: Calx-beta; cl02522 203124001426 Calx-beta domain; Region: Calx-beta; cl02522 203124001427 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124001428 electron transport complex protein RnfC; Provisional; Region: PRK05035 203124001429 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 203124001430 Calx-beta domain; Region: Calx-beta; cl02522 203124001431 Calx-beta domain; Region: Calx-beta; cl02522 203124001432 Calx-beta domain; Region: Calx-beta; cl02522 203124001433 Calx-beta domain; Region: Calx-beta; cl02522 203124001434 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 203124001435 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 203124001436 C-terminal domain interface [polypeptide binding]; other site 203124001437 active site 203124001438 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 203124001439 active site 203124001440 N-terminal domain interface [polypeptide binding]; other site 203124001441 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124001442 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 203124001443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001444 binding surface 203124001445 TPR motif; other site 203124001446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001447 binding surface 203124001448 TPR motif; other site 203124001449 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124001450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001451 binding surface 203124001452 TPR motif; other site 203124001453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001454 binding surface 203124001455 TPR motif; other site 203124001456 CHAT domain; Region: CHAT; cl02083 203124001457 Response regulator receiver domain; Region: Response_reg; pfam00072 203124001458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124001459 active site 203124001460 phosphorylation site [posttranslational modification] 203124001461 intermolecular recognition site; other site 203124001462 dimerization interface [polypeptide binding]; other site 203124001463 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 203124001464 substrate binding site [chemical binding]; other site 203124001465 dimer interface [polypeptide binding]; other site 203124001466 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 203124001467 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 203124001468 putative active site [active] 203124001469 Domain of unknown function (DUF1817); Region: DUF1817; cl02292 203124001470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124001471 active site 203124001472 phosphorylation site [posttranslational modification] 203124001473 intermolecular recognition site; other site 203124001474 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 203124001475 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 203124001476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124001477 active site 203124001478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 203124001479 phosphorylation site [posttranslational modification] 203124001480 intermolecular recognition site; other site 203124001481 dimerization interface [polypeptide binding]; other site 203124001482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124001483 dimer interface [polypeptide binding]; other site 203124001484 phosphorylation site [posttranslational modification] 203124001485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124001486 ATP binding site [chemical binding]; other site 203124001487 Mg2+ binding site [ion binding]; other site 203124001488 G-X-G motif; other site 203124001489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124001490 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 203124001491 DHH family; Region: DHH; pfam01368 203124001492 DHHA1 domain; Region: DHHA1; pfam02272 203124001493 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 203124001494 Double zinc ribbon; Region: DZR; pfam12773 203124001495 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 203124001496 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 203124001497 Active site [active] 203124001498 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 203124001499 phosphopeptide binding site; other site 203124001500 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124001501 active site 203124001502 ATP binding site [chemical binding]; other site 203124001503 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124001504 substrate binding site [chemical binding]; other site 203124001505 activation loop (A-loop); other site 203124001506 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 203124001507 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 203124001508 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 203124001509 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 203124001510 putative active site [active] 203124001511 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 203124001512 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124001513 Walker A/P-loop; other site 203124001514 ATP binding site [chemical binding]; other site 203124001515 Q-loop/lid; other site 203124001516 ABC transporter signature motif; other site 203124001517 Walker B; other site 203124001518 D-loop; other site 203124001519 H-loop/switch region; other site 203124001520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001521 binding surface 203124001522 TPR motif; other site 203124001523 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 203124001524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001525 TPR motif; other site 203124001526 binding surface 203124001527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001528 binding surface 203124001529 TPR motif; other site 203124001530 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001531 binding surface 203124001532 TPR motif; other site 203124001533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001534 binding surface 203124001535 TPR motif; other site 203124001536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001537 binding surface 203124001538 TPR motif; other site 203124001539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001540 binding surface 203124001541 TPR motif; other site 203124001542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001543 binding surface 203124001544 TPR motif; other site 203124001545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001546 binding surface 203124001547 TPR motif; other site 203124001548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001549 binding surface 203124001550 TPR motif; other site 203124001551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001552 binding surface 203124001553 TPR motif; other site 203124001554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001555 binding surface 203124001556 TPR motif; other site 203124001557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001558 binding surface 203124001559 TPR motif; other site 203124001560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001561 binding surface 203124001562 TPR motif; other site 203124001563 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 203124001564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001565 binding surface 203124001566 TPR motif; other site 203124001567 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 203124001568 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 203124001569 ResB-like family; Region: ResB; pfam05140 203124001570 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 203124001571 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 203124001572 PemK-like protein; Region: PemK; cl00995 203124001573 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124001574 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124001575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124001576 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 203124001577 KGK domain; Region: KGK; pfam08872 203124001578 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 203124001579 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 203124001580 Rhomboid family; Region: Rhomboid; cl11446 203124001581 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124001582 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 203124001583 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 203124001584 Stage II sporulation protein; Region: SpoIID; cl07201 203124001585 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 203124001586 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 203124001587 Walker A/P-loop; other site 203124001588 ATP binding site [chemical binding]; other site 203124001589 Q-loop/lid; other site 203124001590 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 203124001591 ABC transporter signature motif; other site 203124001592 Walker B; other site 203124001593 D-loop; other site 203124001594 H-loop/switch region; other site 203124001595 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124001596 GAF domain; Region: GAF; cl00853 203124001597 GAF domain; Region: GAF; cl00853 203124001598 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 203124001599 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 203124001600 cyclase homology domain; Region: CHD; cd07302 203124001601 nucleotidyl binding site; other site 203124001602 metal binding site [ion binding]; metal-binding site 203124001603 dimer interface [polypeptide binding]; other site 203124001604 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 203124001605 Uncharacterized conserved protein [Function unknown]; Region: COG1641; cl03398 203124001606 Protein of unknown function DUF111; Region: DUF111; pfam01969 203124001607 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 203124001608 Calx-beta domain; Region: Calx-beta; cl02522 203124001609 Calx-beta domain; Region: Calx-beta; cl02522 203124001610 Calx-beta domain; Region: Calx-beta; cl02522 203124001611 Calx-beta domain; Region: Calx-beta; cl02522 203124001612 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 203124001613 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 203124001614 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 203124001615 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 203124001616 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 203124001617 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 203124001618 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 203124001619 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 203124001620 dimerization interface [polypeptide binding]; other site 203124001621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124001622 dimer interface [polypeptide binding]; other site 203124001623 phosphorylation site [posttranslational modification] 203124001624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124001625 ATP binding site [chemical binding]; other site 203124001626 Mg2+ binding site [ion binding]; other site 203124001627 G-X-G motif; other site 203124001628 Response regulator receiver domain; Region: Response_reg; pfam00072 203124001629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124001630 active site 203124001631 phosphorylation site [posttranslational modification] 203124001632 intermolecular recognition site; other site 203124001633 dimerization interface [polypeptide binding]; other site 203124001634 cyclase homology domain; Region: CHD; cd07302 203124001635 nucleotidyl binding site; other site 203124001636 metal binding site [ion binding]; metal-binding site 203124001637 dimer interface [polypeptide binding]; other site 203124001638 Cache domain; Region: Cache_1; pfam02743 203124001639 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 203124001640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124001641 dimer interface [polypeptide binding]; other site 203124001642 phosphorylation site [posttranslational modification] 203124001643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124001644 ATP binding site [chemical binding]; other site 203124001645 Mg2+ binding site [ion binding]; other site 203124001646 G-X-G motif; other site 203124001647 Response regulator receiver domain; Region: Response_reg; pfam00072 203124001648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124001649 active site 203124001650 phosphorylation site [posttranslational modification] 203124001651 intermolecular recognition site; other site 203124001652 dimerization interface [polypeptide binding]; other site 203124001653 cyclase homology domain; Region: CHD; cd07302 203124001654 nucleotidyl binding site; other site 203124001655 metal binding site [ion binding]; metal-binding site 203124001656 dimer interface [polypeptide binding]; other site 203124001657 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 203124001658 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change...; Region: AcnB_Swivel; cd01576 203124001659 substrate binding site [chemical binding]; other site 203124001660 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 203124001661 substrate binding site [chemical binding]; other site 203124001662 ligand binding site [chemical binding]; other site 203124001663 PAS domain S-box; Region: sensory_box; TIGR00229 203124001664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 203124001665 putative active site [active] 203124001666 heme pocket [chemical binding]; other site 203124001667 PAS domain S-box; Region: sensory_box; TIGR00229 203124001668 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 203124001669 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 203124001670 metal binding site [ion binding]; metal-binding site 203124001671 active site 203124001672 I-site; other site 203124001673 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 203124001674 Calx-beta domain; Region: Calx-beta; cl02522 203124001675 Calx-beta domain; Region: Calx-beta; cl02522 203124001676 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 203124001677 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 203124001678 Probable transposase; Region: OrfB_IS605; pfam01385 203124001679 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 203124001680 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 203124001681 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 203124001682 Walker A/P-loop; other site 203124001683 ATP binding site [chemical binding]; other site 203124001684 Q-loop/lid; other site 203124001685 ABC transporter signature motif; other site 203124001686 Walker B; other site 203124001687 D-loop; other site 203124001688 H-loop/switch region; other site 203124001689 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 203124001690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124001691 active site 203124001692 phosphorylation site [posttranslational modification] 203124001693 intermolecular recognition site; other site 203124001694 dimerization interface [polypeptide binding]; other site 203124001695 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 203124001696 DNA binding site [nucleotide binding] 203124001697 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 203124001698 putative GSH binding site [chemical binding]; other site 203124001699 catalytic residues [active] 203124001700 BolA-like protein; Region: BolA; cl00386 203124001701 riboflavin kinase; Region: PLN02940 203124001702 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 203124001703 motif II; other site 203124001704 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 203124001705 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-...; Region: FBPase; cd00354 203124001706 AMP binding site [chemical binding]; other site 203124001707 metal binding site [ion binding]; metal-binding site 203124001708 active site 203124001709 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 203124001710 putative active site [active] 203124001711 transaldolase; Provisional; Region: PRK03903 203124001712 catalytic residue [active] 203124001713 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 203124001714 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 203124001715 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 203124001716 opcA protein; Region: OpcA; TIGR00534 203124001717 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 203124001718 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 203124001719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124001720 S-adenosylmethionine binding site [chemical binding]; other site 203124001721 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 203124001722 homooctamer interface [polypeptide binding]; other site 203124001723 active site 203124001724 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 203124001725 catalytic center binding site [active] 203124001726 ATP binding site [chemical binding]; other site 203124001727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124001728 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 203124001729 tetramerization interface [polypeptide binding]; other site 203124001730 active site 203124001731 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 203124001732 substrate binding pocket [chemical binding]; other site 203124001733 active site 203124001734 iron coordination sites [ion binding]; other site 203124001735 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 203124001736 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 203124001737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124001738 NAD(P) binding site [chemical binding]; other site 203124001739 active site 203124001740 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 203124001741 dihydropteroate synthase; Region: DHPS; TIGR01496 203124001742 substrate binding pocket [chemical binding]; other site 203124001743 dimer interface [polypeptide binding]; other site 203124001744 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 203124001745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124001746 NAD(P) binding site [chemical binding]; other site 203124001747 active site 203124001748 dihydropteroate synthase; Region: DHPS; TIGR01496 203124001749 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 203124001750 substrate binding pocket [chemical binding]; other site 203124001751 dimer interface [polypeptide binding]; other site 203124001752 inhibitor binding site; inhibition site 203124001753 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 203124001754 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 203124001755 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 203124001756 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124001757 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 203124001758 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 203124001759 putative metal binding site [ion binding]; other site 203124001760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124001761 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 203124001762 Bacterial SH3 domain; Region: SH3_3; cl02551 203124001763 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 203124001764 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 203124001765 DNA binding residues [nucleotide binding] 203124001766 HrcA protein C terminal domain; Region: HrcA; pfam01628 203124001767 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 203124001768 active site residue [active] 203124001769 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 203124001770 putative binding surface; other site 203124001771 active site 203124001772 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 203124001773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124001774 ATP binding site [chemical binding]; other site 203124001775 Mg2+ binding site [ion binding]; other site 203124001776 G-X-G motif; other site 203124001777 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 203124001778 Response regulator receiver domain; Region: Response_reg; pfam00072 203124001779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124001780 active site 203124001781 phosphorylation site [posttranslational modification] 203124001782 intermolecular recognition site; other site 203124001783 dimerization interface [polypeptide binding]; other site 203124001784 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124001785 GAF domain; Region: GAF; cl00853 203124001786 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124001787 GAF domain; Region: GAF; cl00853 203124001788 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124001789 GAF domain; Region: GAF; cl00853 203124001790 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124001791 GAF domain; Region: GAF; cl00853 203124001792 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124001793 GAF domain; Region: GAF; cl00853 203124001794 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 203124001795 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 203124001796 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 203124001797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124001798 Response regulator receiver domain; Region: Response_reg; pfam00072 203124001799 active site 203124001800 phosphorylation site [posttranslational modification] 203124001801 intermolecular recognition site; other site 203124001802 dimerization interface [polypeptide binding]; other site 203124001803 Response regulator receiver domain; Region: Response_reg; pfam00072 203124001804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124001805 active site 203124001806 phosphorylation site [posttranslational modification] 203124001807 intermolecular recognition site; other site 203124001808 dimerization interface [polypeptide binding]; other site 203124001809 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 203124001810 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 203124001811 TPP-binding site [chemical binding]; other site 203124001812 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 203124001813 PYR/PP interface [polypeptide binding]; other site 203124001814 dimer interface [polypeptide binding]; other site 203124001815 TPP binding site [chemical binding]; other site 203124001816 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 203124001817 spermine synthase; Region: PLN02823 203124001818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124001819 S-adenosylmethionine binding site [chemical binding]; other site 203124001820 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 203124001821 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 203124001822 putative substrate binding site [chemical binding]; other site 203124001823 putative ATP binding site [chemical binding]; other site 203124001824 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 203124001825 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 203124001826 Ligand Binding Site [chemical binding]; other site 203124001827 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 203124001828 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 203124001829 Active site cavity [active] 203124001830 catalytic acid [active] 203124001831 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 203124001832 diiron binding motif [ion binding]; other site 203124001833 ribosomal protein L32; Validated; Region: rpl32; CHL00152 203124001834 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 203124001835 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 203124001836 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 203124001837 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124001838 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124001839 secreted effector protein PipB2; Provisional; Region: PRK15196 203124001840 DNA primase; Validated; Region: dnaG; PRK05667 203124001841 CHC2 zinc finger; Region: zf-CHC2; cl02597 203124001842 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 203124001843 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 203124001844 active site 203124001845 metal binding site [ion binding]; metal-binding site 203124001846 interdomain interaction site; other site 203124001847 Protein of unknown function (DUF502); Region: DUF502; cl01107 203124001848 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 203124001849 putative RNA binding site [nucleotide binding]; other site 203124001850 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 203124001851 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 203124001852 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 203124001853 P loop; other site 203124001854 GTP binding site [chemical binding]; other site 203124001855 GAF domain; Region: GAF; cl00853 203124001856 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 203124001857 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 203124001858 argininosuccinate lyase; Provisional; Region: PRK00855 203124001859 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 203124001860 active sites [active] 203124001861 tetramer interface [polypeptide binding]; other site 203124001862 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 203124001863 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 203124001864 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 203124001865 16S rRNA methyltransferase B; Provisional; Region: PRK14901 203124001866 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 203124001867 putative RNA binding site [nucleotide binding]; other site 203124001868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124001869 S-adenosylmethionine binding site [chemical binding]; other site 203124001870 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 203124001871 alpha-gamma subunit interface [polypeptide binding]; other site 203124001872 beta-gamma subunit interface [polypeptide binding]; other site 203124001873 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 203124001874 gamma-beta subunit interface [polypeptide binding]; other site 203124001875 alpha-beta subunit interface [polypeptide binding]; other site 203124001876 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124001877 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124001878 Switch II region; other site 203124001879 G4 box; other site 203124001880 G5 box; other site 203124001881 UreD urease accessory protein; Region: UreD; cl00530 203124001882 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-...; Region: UreE; cd00571 203124001883 dimer interface [polypeptide binding]; other site 203124001884 catalytic residues [active] 203124001885 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 203124001886 UreF; Region: UreF; pfam01730 203124001887 urease subunit alpha; Reviewed; Region: ureC; PRK13207 203124001888 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 203124001889 subunit interactions [polypeptide binding]; other site 203124001890 active site 203124001891 flap region; other site 203124001892 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 203124001893 catalytic loop [active] 203124001894 iron binding site [ion binding]; other site 203124001895 Staphylococcal nuclease homologues; Region: SNc; smart00318 203124001896 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 203124001897 Catalytic site; other site 203124001898 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 203124001899 active site 203124001900 dimerization interface [polypeptide binding]; other site 203124001901 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 203124001902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001903 binding surface 203124001904 TPR motif; other site 203124001905 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 203124001906 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 203124001907 dimer interface [polypeptide binding]; other site 203124001908 motif 1; other site 203124001909 active site 203124001910 motif 2; other site 203124001911 motif 3; other site 203124001912 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 203124001913 anticodon binding site; other site 203124001914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124001915 Peptidase family M48; Region: Peptidase_M48; cl12018 203124001916 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124001917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001918 binding surface 203124001919 TPR motif; other site 203124001920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001921 binding surface 203124001922 TPR motif; other site 203124001923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001924 binding surface 203124001925 TPR motif; other site 203124001926 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 203124001927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001928 binding surface 203124001929 TPR motif; other site 203124001930 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124001931 binding surface 203124001932 TPR motif; other site 203124001933 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 203124001934 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 203124001935 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 203124001936 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 203124001937 dimer interface [polypeptide binding]; other site 203124001938 putative functional site; other site 203124001939 putative MPT binding site; other site 203124001940 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 203124001941 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 203124001942 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 203124001943 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 203124001944 Flavin Reductases; Region: FlaRed; cl00801 203124001945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 203124001946 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 203124001947 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 203124001948 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 203124001949 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124001950 RNA polymerase sigma factor; Validated; Region: PRK05949 203124001951 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 203124001952 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 203124001953 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 203124001954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 203124001955 DNA binding residues [nucleotide binding] 203124001956 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 203124001957 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 203124001958 homodimer interface [polypeptide binding]; other site 203124001959 Walker A motif; other site 203124001960 ATP binding site [chemical binding]; other site 203124001961 hydroxycobalamin binding site [chemical binding]; other site 203124001962 Walker B motif; other site 203124001963 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124001964 Acylphosphatase; Region: Acylphosphatase; cl00551 203124001965 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 203124001966 HypF finger; Region: zf-HYPF; pfam07503 203124001967 HypF finger; Region: zf-HYPF; pfam07503 203124001968 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 203124001969 HupF/HypC family; Region: HupF_HypC; cl00394 203124001970 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 203124001971 Hydrogenase formation hypA family; Region: HypD; cl12072 203124001972 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 203124001973 dimerization interface [polypeptide binding]; other site 203124001974 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 203124001975 ATP binding site [chemical binding]; other site 203124001976 Hydrogenase expression/synthesis hypA family; Region: HypA; cl00418 203124001977 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 203124001978 TM-ABC transporter signature motif; other site 203124001979 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 203124001980 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 203124001981 Walker A/P-loop; other site 203124001982 ATP binding site [chemical binding]; other site 203124001983 Q-loop/lid; other site 203124001984 ABC transporter signature motif; other site 203124001985 Walker B; other site 203124001986 D-loop; other site 203124001987 H-loop/switch region; other site 203124001988 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 203124001989 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 203124001990 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 203124001991 ligand binding site [chemical binding]; other site 203124001992 calcium binding site [ion binding]; other site 203124001993 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 203124001994 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124001995 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 203124001996 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 203124001997 Ligand binding site [chemical binding]; other site 203124001998 Putative Catalytic site [active] 203124001999 DXD motif; other site 203124002000 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 203124002001 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 203124002002 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124002003 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124002004 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 203124002005 active site 203124002006 catalytic residues [active] 203124002007 metal binding site [ion binding]; metal-binding site 203124002008 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 203124002009 Mechanosensitive ion channel; Region: MS_channel; pfam00924 203124002010 Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the...; Region: DEP; cd04371 203124002011 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 203124002012 active site 203124002013 nucleophile elbow; other site 203124002014 MAC/Perforin domain; Region: MACPF; cl02616 203124002015 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 203124002016 metal ion-dependent adhesion site (MIDAS); other site 203124002017 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 203124002018 Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419 203124002019 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124002020 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124002021 HEAT repeat; Region: HEAT; pfam02985 203124002022 HEAT repeat; Region: HEAT; pfam02985 203124002023 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 203124002024 active site 203124002025 dimer interfaces [polypeptide binding]; other site 203124002026 catalytic residues [active] 203124002027 putative lipid kinase; Reviewed; Region: PRK00861 203124002028 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 203124002029 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 203124002030 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 203124002031 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 203124002032 Walker A/P-loop; other site 203124002033 ATP binding site [chemical binding]; other site 203124002034 Q-loop/lid; other site 203124002035 ABC transporter signature motif; other site 203124002036 Walker B; other site 203124002037 D-loop; other site 203124002038 H-loop/switch region; other site 203124002039 Multicopper oxidase; Region: Cu-oxidase; cl14658 203124002040 Multicopper oxidase; Region: Cu-oxidase; cl14658 203124002041 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 203124002042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124002043 Walker A motif; other site 203124002044 ATP binding site [chemical binding]; other site 203124002045 Walker B motif; other site 203124002046 arginine finger; other site 203124002047 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 203124002048 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 203124002049 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 203124002050 S-layer homology domain; Region: SLH; pfam00395 203124002051 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 203124002052 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 203124002053 dimer interface [polypeptide binding]; other site 203124002054 [2Fe-2S] cluster binding site [ion binding]; other site 203124002055 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 203124002056 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 203124002057 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 203124002058 THF binding site; other site 203124002059 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 203124002060 substrate binding site [chemical binding]; other site 203124002061 THF binding site; other site 203124002062 zinc-binding site [ion binding]; other site 203124002063 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124002064 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 203124002065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002066 binding surface 203124002067 TPR motif; other site 203124002068 CHAT domain; Region: CHAT; cl02083 203124002069 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124002070 active site 203124002071 ATP binding site [chemical binding]; other site 203124002072 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124002073 substrate binding site [chemical binding]; other site 203124002074 activation loop (A-loop); other site 203124002075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002076 TPR motif; other site 203124002077 binding surface 203124002078 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 203124002079 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 203124002080 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 203124002081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124002082 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124002083 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 203124002084 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein...; Region: SSP411; cd02955 203124002085 catalytic residues [active] 203124002086 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 203124002087 substrate binding site [chemical binding]; other site 203124002088 dimer interface [polypeptide binding]; other site 203124002089 ATP binding site [chemical binding]; other site 203124002090 magnesium chelatase subunit H; Provisional; Region: PLN03241 203124002091 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 203124002092 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 203124002093 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124002094 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 203124002095 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 203124002096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124002097 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 203124002098 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124002099 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 203124002100 dimerization interface [polypeptide binding]; other site 203124002101 Metal binding site [ion binding]; metal-binding site 203124002102 UbiA prenyltransferase family; Region: UbiA; cl00337 203124002103 Transglycosylase; Region: Transgly; cl07896 203124002104 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 203124002105 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 203124002106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124002107 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 203124002108 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 203124002109 Protein export membrane protein; Region: SecD_SecF; cl14618 203124002110 Staphylococcal nuclease homologues; Region: SNc; smart00318 203124002111 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 203124002112 Catalytic site; other site 203124002113 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 203124002114 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 203124002115 ANP binding site [chemical binding]; other site 203124002116 Substrate Binding Site II [chemical binding]; other site 203124002117 Substrate Binding Site I [chemical binding]; other site 203124002118 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 203124002119 active site 203124002120 spermine synthase; Region: PLN02823 203124002121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124002122 S-adenosylmethionine binding site [chemical binding]; other site 203124002123 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 203124002124 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 203124002125 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 203124002126 homodimer interface [polypeptide binding]; other site 203124002127 substrate-cofactor binding pocket; other site 203124002128 catalytic residue [active] 203124002129 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 203124002130 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 203124002131 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 203124002132 Catalytic site [active] 203124002133 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 203124002134 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 203124002135 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 203124002136 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 203124002137 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 203124002138 active site 203124002139 NTP binding site [chemical binding]; other site 203124002140 metal binding triad [ion binding]; metal-binding site 203124002141 antibiotic binding site [chemical binding]; other site 203124002142 FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 203124002143 putative active site [active] 203124002144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203124002145 Coenzyme A binding pocket [chemical binding]; other site 203124002146 Transposase IS200 like; Region: Y1_Tnp; cl00848 203124002147 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 203124002148 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39D; cd02420 203124002149 putative active site [active] 203124002150 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 203124002151 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124002152 Walker A/P-loop; other site 203124002153 ATP binding site [chemical binding]; other site 203124002154 Q-loop/lid; other site 203124002155 ABC transporter signature motif; other site 203124002156 Walker B; other site 203124002157 D-loop; other site 203124002158 H-loop/switch region; other site 203124002159 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 203124002160 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 203124002161 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124002162 Walker A/P-loop; other site 203124002163 ATP binding site [chemical binding]; other site 203124002164 Q-loop/lid; other site 203124002165 ABC transporter signature motif; other site 203124002166 Walker B; other site 203124002167 D-loop; other site 203124002168 H-loop/switch region; other site 203124002169 CbiD; Region: CbiD; cl00828 203124002170 GMP synthase; Reviewed; Region: guaA; PRK00074 203124002171 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 203124002172 AMP/PPi binding site [chemical binding]; other site 203124002173 candidate oxyanion hole; other site 203124002174 catalytic triad [active] 203124002175 potential glutamine specificity residues [chemical binding]; other site 203124002176 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 203124002177 ATP Binding subdomain [chemical binding]; other site 203124002178 Ligand Binding sites [chemical binding]; other site 203124002179 Dimerization subdomain; other site 203124002180 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 203124002181 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 203124002182 phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418 203124002183 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 203124002184 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 203124002185 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 203124002186 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 203124002187 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 203124002188 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 203124002189 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 203124002190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124002191 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 203124002192 catalytic loop [active] 203124002193 iron binding site [ion binding]; other site 203124002194 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 203124002195 catalytic loop [active] 203124002196 iron binding site [ion binding]; other site 203124002197 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 203124002198 catalytic loop [active] 203124002199 iron binding site [ion binding]; other site 203124002200 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 203124002201 Stage II sporulation protein; Region: SpoIID; cl07201 203124002202 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cl03075 203124002203 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 203124002204 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 203124002205 anti sigma factor interaction site; other site 203124002206 regulatory phosphorylation site [posttranslational modification]; other site 203124002207 Response regulator receiver domain; Region: Response_reg; pfam00072 203124002208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124002209 active site 203124002210 phosphorylation site [posttranslational modification] 203124002211 intermolecular recognition site; other site 203124002212 dimerization interface [polypeptide binding]; other site 203124002213 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 203124002214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 203124002215 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124002216 TLC ATP/ADP transporter; Region: TLC; cl03940 203124002217 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124002218 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 203124002219 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 203124002220 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 203124002221 hydrolase, alpha/beta fold family protein; Region: PLN02679 203124002222 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 203124002223 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124002224 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124002225 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 203124002226 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124002227 Integrase core domain; Region: rve; cl01316 203124002228 CHASE4 domain; Region: CHASE4; cl01308 203124002229 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 203124002230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 203124002231 PAS fold; Region: PAS_3; pfam08447 203124002232 putative active site [active] 203124002233 heme pocket [chemical binding]; other site 203124002234 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124002235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124002236 dimer interface [polypeptide binding]; other site 203124002237 phosphorylation site [posttranslational modification] 203124002238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124002239 ATP binding site [chemical binding]; other site 203124002240 Mg2+ binding site [ion binding]; other site 203124002241 G-X-G motif; other site 203124002242 Response regulator receiver domain; Region: Response_reg; pfam00072 203124002243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124002244 active site 203124002245 phosphorylation site [posttranslational modification] 203124002246 intermolecular recognition site; other site 203124002247 dimerization interface [polypeptide binding]; other site 203124002248 Response regulator receiver domain; Region: Response_reg; pfam00072 203124002249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124002250 active site 203124002251 phosphorylation site [posttranslational modification] 203124002252 intermolecular recognition site; other site 203124002253 dimerization interface [polypeptide binding]; other site 203124002254 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 203124002255 aspartate aminotransferase; Provisional; Region: PRK07681 203124002256 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 203124002257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124002258 homodimer interface [polypeptide binding]; other site 203124002259 catalytic residue [active] 203124002260 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 203124002261 catalytic residues [active] 203124002262 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 203124002263 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 203124002264 putative active site [active] 203124002265 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 203124002266 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 203124002267 tRNA; other site 203124002268 putative tRNA binding site [nucleotide binding]; other site 203124002269 putative NADP binding site [chemical binding]; other site 203124002270 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 203124002271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124002272 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 203124002273 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 203124002274 Ycf27; Reviewed; Region: orf27; CHL00148 203124002275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124002276 active site 203124002277 phosphorylation site [posttranslational modification] 203124002278 intermolecular recognition site; other site 203124002279 dimerization interface [polypeptide binding]; other site 203124002280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 203124002281 DNA binding site [nucleotide binding] 203124002282 DNA repair protein RadA; Provisional; Region: PRK11823 203124002283 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 203124002284 Walker A motif/ATP binding site; other site 203124002285 ATP binding site [chemical binding]; other site 203124002286 Walker B motif; other site 203124002287 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 203124002288 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 203124002289 NAD binding site [chemical binding]; other site 203124002290 substrate binding site [chemical binding]; other site 203124002291 homodimer interface [polypeptide binding]; other site 203124002292 active site 203124002293 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 203124002294 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 203124002295 putative active site [active] 203124002296 putative metal binding site [ion binding]; other site 203124002297 Predicted helicase [General function prediction only]; Region: COG4889 203124002298 Predicted helicase [General function prediction only]; Region: COG4889 203124002299 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 203124002300 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 203124002301 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 203124002302 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 203124002303 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 203124002304 homodecamer interface [polypeptide binding]; other site 203124002305 GTP cyclohydrolase I; Provisional; Region: PLN03044 203124002306 active site 203124002307 putative catalytic site residues [active] 203124002308 zinc binding site [ion binding]; other site 203124002309 GTP-CH-I/GFRP interaction surface; other site 203124002310 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 203124002311 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a...; Region: PGM_like2; cd05800 203124002312 active site 203124002313 substrate binding site [chemical binding]; other site 203124002314 metal binding site [ion binding]; metal-binding site 203124002315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 203124002316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 203124002317 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 203124002318 D-xylulose kinase; Region: XylB; TIGR01312 203124002319 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 203124002320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002321 binding surface 203124002322 TPR motif; other site 203124002323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002324 binding surface 203124002325 TPR motif; other site 203124002326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002327 binding surface 203124002328 TPR motif; other site 203124002329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002330 binding surface 203124002331 TPR motif; other site 203124002332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002333 binding surface 203124002334 TPR motif; other site 203124002335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002336 binding surface 203124002337 TPR motif; other site 203124002338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002339 binding surface 203124002340 TPR motif; other site 203124002341 CHAT domain; Region: CHAT; cl02083 203124002342 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124002343 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin...; Region: ARM; cl02500 203124002344 protein binding surface [polypeptide binding]; other site 203124002345 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 203124002346 Vesicle coat complex, various subunits [Intracellular trafficking and secretion]; Region: COG5096 203124002347 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 203124002348 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 203124002349 Phycobilisome protein; Region: Phycobilisome; cl08227 203124002350 Phycobilisome protein; Region: Phycobilisome; cl08227 203124002351 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 203124002352 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 203124002353 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 203124002354 ribonuclease E; Reviewed; Region: rne; PRK10811 203124002355 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124002356 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 203124002357 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 203124002358 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 203124002359 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124002360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124002361 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124002362 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin...; Region: ARM; cl02500 203124002363 protein binding surface [polypeptide binding]; other site 203124002364 Phycobilisome protein; Region: Phycobilisome; cl08227 203124002365 Phycobilisome protein; Region: Phycobilisome; cl08227 203124002366 Phycobilisome protein; Region: Phycobilisome; cl08227 203124002367 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 203124002368 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 203124002369 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 203124002370 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 203124002371 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 203124002372 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 203124002373 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 203124002374 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 203124002375 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 203124002376 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 203124002377 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 203124002378 NAD(P) binding site [chemical binding]; other site 203124002379 putative active site [active] 203124002380 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 203124002381 N-acetyl-D-glucosamine binding site [chemical binding]; other site 203124002382 catalytic residue [active] 203124002383 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 203124002384 active site 203124002385 dimerization interface [polypeptide binding]; other site 203124002386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124002387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124002388 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 203124002389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002390 binding surface 203124002391 TPR motif; other site 203124002392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002393 binding surface 203124002394 TPR motif; other site 203124002395 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 203124002396 Sulfatase; Region: Sulfatase; cl10460 203124002397 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 203124002398 MORN repeat; Region: MORN; cl14787 203124002399 Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; cl03585 203124002400 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 203124002401 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 203124002402 DNA binding site [nucleotide binding] 203124002403 catalytic residue [active] 203124002404 H2TH interface [polypeptide binding]; other site 203124002405 putative catalytic residues [active] 203124002406 turnover-facilitating residue; other site 203124002407 intercalation triad [nucleotide binding]; other site 203124002408 8OG recognition residue [nucleotide binding]; other site 203124002409 putative reading head residues; other site 203124002410 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 203124002411 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 203124002412 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 203124002413 homoserine kinase; Provisional; Region: PRK01212 203124002414 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 203124002415 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 203124002416 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 203124002417 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 203124002418 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 203124002419 5-oxoprolinase; Region: PLN02666 203124002420 Sulfate transporter family; Region: Sulfate_transp; cl00967 203124002421 Permease family; Region: Xan_ur_permease; pfam00860 203124002422 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 203124002423 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 203124002424 putative active site [active] 203124002425 metal binding site [ion binding]; metal-binding site 203124002426 aspartate aminotransferase; Provisional; Region: PRK07681 203124002427 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 203124002428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124002429 homodimer interface [polypeptide binding]; other site 203124002430 catalytic residue [active] 203124002431 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124002432 HupE / UreJ protein; Region: HupE_UreJ; cl01011 203124002433 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 203124002434 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124002435 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 203124002436 Integrin, beta chain; Region: Integrin_beta; pfam00362 203124002437 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 203124002438 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 203124002439 Protein kinase domain; Region: Pkinase; pfam00069 203124002440 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124002441 active site 203124002442 ATP binding site [chemical binding]; other site 203124002443 substrate binding site [chemical binding]; other site 203124002444 activation loop (A-loop); other site 203124002445 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 203124002446 phosphopeptide binding site; other site 203124002447 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124002448 putative active site [active] 203124002449 putative NTP binding site [chemical binding]; other site 203124002450 putative nucleic acid binding site [nucleotide binding]; other site 203124002451 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 203124002452 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124002453 active site 203124002454 ATP binding site [chemical binding]; other site 203124002455 substrate binding site [chemical binding]; other site 203124002456 activation loop (A-loop); other site 203124002457 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124002458 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 203124002459 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 203124002460 ligand binding site [chemical binding]; other site 203124002461 flexible hinge region; other site 203124002462 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 203124002463 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 203124002464 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even...; Region: PDZ_glycyl_aminopeptidase; cd00990 203124002465 protein binding site [polypeptide binding]; other site 203124002466 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 203124002467 tellurium resistance terB-like protein; Region: terB_like; cd07177 203124002468 metal binding site [ion binding]; metal-binding site 203124002469 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 203124002470 substrate binding site [chemical binding]; other site 203124002471 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 203124002472 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 203124002473 Integrase core domain; Region: rve; cl01316 203124002474 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 203124002475 Ycf46; Provisional; Region: ycf46; CHL00195 203124002476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124002477 Walker A motif; other site 203124002478 ATP binding site [chemical binding]; other site 203124002479 Walker B motif; other site 203124002480 arginine finger; other site 203124002481 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 203124002482 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 203124002483 active site 203124002484 catalytic site [active] 203124002485 metal binding site [ion binding]; metal-binding site 203124002486 S-layer homology domain; Region: SLH; pfam00395 203124002487 S-layer homology domain; Region: SLH; pfam00395 203124002488 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 203124002489 Sulfate transporter family; Region: Sulfate_transp; cl00967 203124002490 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 203124002491 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 203124002492 Sulfate transporter family; Region: Sulfate_transp; cl00967 203124002493 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 203124002494 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 203124002495 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 203124002496 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 203124002497 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 203124002498 active site 203124002499 NTP binding site [chemical binding]; other site 203124002500 metal binding triad [ion binding]; metal-binding site 203124002501 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 203124002502 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 203124002503 Mechanosensitive ion channel; Region: MS_channel; pfam00924 203124002504 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 203124002505 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124002506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124002507 S-adenosylmethionine binding site [chemical binding]; other site 203124002508 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 203124002509 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 203124002510 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 203124002511 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 203124002512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203124002513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203124002514 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 203124002515 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 203124002516 [4Fe-4S] binding site [ion binding]; other site 203124002517 molybdopterin cofactor binding site; other site 203124002518 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 203124002519 molybdopterin cofactor binding site; other site 203124002520 PemK-like protein; Region: PemK; cl00995 203124002521 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 203124002522 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 203124002523 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 203124002524 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 203124002525 substrate binding pocket [chemical binding]; other site 203124002526 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 203124002527 B12 binding site [chemical binding]; other site 203124002528 cobalt ligand [ion binding]; other site 203124002529 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 203124002530 Response regulator receiver domain; Region: Response_reg; pfam00072 203124002531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124002532 active site 203124002533 phosphorylation site [posttranslational modification] 203124002534 intermolecular recognition site; other site 203124002535 dimerization interface [polypeptide binding]; other site 203124002536 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 203124002537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124002538 ATP binding site [chemical binding]; other site 203124002539 Mg2+ binding site [ion binding]; other site 203124002540 G-X-G motif; other site 203124002541 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 203124002542 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 203124002543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124002544 NAD(P) binding site [chemical binding]; other site 203124002545 active site 203124002546 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 203124002547 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 203124002548 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl01426 203124002549 ABC-2 type transporter; Region: ABC2_membrane; cl11417 203124002550 phosphoglucomutase; Region: PLN02307 203124002551 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one...; Region: PGM1; cd03085 203124002552 substrate binding site [chemical binding]; other site 203124002553 dimer interface [polypeptide binding]; other site 203124002554 active site 203124002555 metal binding site [ion binding]; metal-binding site 203124002556 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 203124002557 Phage Tail Collar Domain; Region: Collar; pfam07484 203124002558 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 203124002559 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 203124002560 active site 203124002561 substrate binding site [chemical binding]; other site 203124002562 metal binding site [ion binding]; metal-binding site 203124002563 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124002564 active site 203124002565 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 203124002566 Ligand binding site [chemical binding]; other site 203124002567 metal binding site [ion binding]; metal-binding site 203124002568 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124002569 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (; Region: GT1_wlbH_like; cd03798 203124002570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124002571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 203124002572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002573 binding surface 203124002574 TPR motif; other site 203124002575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002576 binding surface 203124002577 TPR motif; other site 203124002578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002579 binding surface 203124002580 TPR motif; other site 203124002581 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002582 binding surface 203124002583 TPR motif; other site 203124002584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002585 TPR motif; other site 203124002586 binding surface 203124002587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002588 binding surface 203124002589 TPR motif; other site 203124002590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002591 binding surface 203124002592 TPR motif; other site 203124002593 CHAT domain; Region: CHAT; cl02083 203124002594 CHAT domain; Region: CHAT; cl02083 203124002595 ribonuclease III; Reviewed; Region: rnc; PRK00102 203124002596 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 203124002597 dimerization interface [polypeptide binding]; other site 203124002598 active site 203124002599 metal binding site [ion binding]; metal-binding site 203124002600 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cl00054 203124002601 dsRNA binding site [nucleotide binding]; other site 203124002602 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 203124002603 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 203124002604 hypothetical protein; Validated; Region: PRK07411 203124002605 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 203124002606 ATP binding site [chemical binding]; other site 203124002607 substrate interface [chemical binding]; other site 203124002608 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 203124002609 active site residue [active] 203124002610 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 203124002611 MPN+ (JAMM) motif; other site 203124002612 Zinc-binding site [ion binding]; other site 203124002613 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 203124002614 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 203124002615 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 203124002616 DNA photolyase; Region: DNA_photolyase; pfam00875 203124002617 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 203124002618 polyphosphate kinase; Provisional; Region: PRK05443 203124002619 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 203124002620 putative domain interface [polypeptide binding]; other site 203124002621 putative active site [active] 203124002622 catalytic site [active] 203124002623 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 203124002624 putative domain interface [polypeptide binding]; other site 203124002625 putative active site [active] 203124002626 catalytic site [active] 203124002627 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 203124002628 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124002629 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 203124002630 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 203124002631 active site 203124002632 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124002633 putative active site [active] 203124002634 putative NTP binding site [chemical binding]; other site 203124002635 putative nucleic acid binding site [nucleotide binding]; other site 203124002636 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 203124002637 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 203124002638 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 203124002639 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 203124002640 dimer interface [polypeptide binding]; other site 203124002641 ADP-ribose binding site [chemical binding]; other site 203124002642 active site 203124002643 nudix motif; other site 203124002644 metal binding site [ion binding]; metal-binding site 203124002645 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 203124002646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124002647 dimer interface [polypeptide binding]; other site 203124002648 conserved gate region; other site 203124002649 ABC-ATPase subunit interface; other site 203124002650 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 203124002651 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 203124002652 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 203124002653 purine monophosphate binding site [chemical binding]; other site 203124002654 dimer interface [polypeptide binding]; other site 203124002655 putative catalytic residues [active] 203124002656 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 203124002657 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 203124002658 heat shock 70 kDa protein; Provisional; Region: PTZ00009 203124002659 Protein of unknown function (DUF812); Region: DUF812; pfam05667 203124002660 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124002661 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124002662 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 203124002663 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cd00290 203124002664 interchain domain interface [polypeptide binding]; other site 203124002665 intrachain domain interface; other site 203124002666 Qi binding site; other site 203124002667 Qo binding site; other site 203124002668 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284 203124002669 Qi binding site; other site 203124002670 intrachain domain interface; other site 203124002671 interchain domain interface [polypeptide binding]; other site 203124002672 heme bH binding site [chemical binding]; other site 203124002673 heme bL binding site [chemical binding]; other site 203124002674 Qo binding site; other site 203124002675 carboxyl-terminal processing protease; Provisional; Region: PLN00049 203124002676 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 203124002677 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 203124002678 protein binding site [polypeptide binding]; other site 203124002679 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 203124002680 Catalytic dyad [active] 203124002681 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 203124002682 active site 203124002683 multimer interface [polypeptide binding]; other site 203124002684 arginine decarboxylase; Provisional; Region: PRK05354 203124002685 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 203124002686 dimer interface [polypeptide binding]; other site 203124002687 active site 203124002688 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 203124002689 catalytic residues [active] 203124002690 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 203124002691 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 203124002692 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 203124002693 active site 203124002694 Substrate binding site [chemical binding]; other site 203124002695 Mg++ binding site [ion binding]; other site 203124002696 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 203124002697 putative trimer interface [polypeptide binding]; other site 203124002698 putative CoA binding site [chemical binding]; other site 203124002699 ScpA/B protein; Region: ScpA_ScpB; cl00598 203124002700 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 203124002701 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 203124002702 dimer interface [polypeptide binding]; other site 203124002703 ssDNA binding site [nucleotide binding]; other site 203124002704 tetramer (dimer of dimers) interface [polypeptide binding]; other site 203124002705 rod shape-determining protein MreB; Provisional; Region: PRK13927 203124002706 Cell division protein FtsA; Region: FtsA; cl11496 203124002707 rod shape-determining protein MreC; Region: MreC; pfam04085 203124002708 rod shape-determining protein MreD; Region: MreD; cl01087 203124002709 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 203124002710 feedback inhibition sensing region; other site 203124002711 homohexameric interface [polypeptide binding]; other site 203124002712 nucleotide binding site [chemical binding]; other site 203124002713 N-acetyl-L-glutamate binding site [chemical binding]; other site 203124002714 YtxH-like protein; Region: YtxH; cl02079 203124002715 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 203124002716 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 203124002717 generic binding surface II; other site 203124002718 ssDNA binding site; other site 203124002719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124002720 putative Mg++ binding site [ion binding]; other site 203124002721 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203124002722 nucleotide binding region [chemical binding]; other site 203124002723 ATP-binding site [chemical binding]; other site 203124002724 elongation factor Ts; Reviewed; Region: tsf; PRK12332 203124002725 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 203124002726 Elongation factor TS; Region: EF_TS; pfam00889 203124002727 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 203124002728 rRNA interaction site [nucleotide binding]; other site 203124002729 S8 interaction site; other site 203124002730 putative laminin-1 binding site; other site 203124002731 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 203124002732 antiporter inner membrane protein; Provisional; Region: PRK11670 203124002733 Domain of unknown function DUF59; Region: DUF59; cl00941 203124002734 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 203124002735 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 203124002736 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 203124002737 anti sigma factor interaction site; other site 203124002738 regulatory phosphorylation site [posttranslational modification]; other site 203124002739 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 203124002740 Late competence development protein ComFB; Region: ComFB; pfam10719 203124002741 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 203124002742 Peptidase family M23; Region: Peptidase_M23; pfam01551 203124002743 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 203124002744 diaminopimelate epimerase; Region: PLN02536 203124002745 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 203124002746 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 203124002747 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 203124002748 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 203124002749 GTP binding site [chemical binding]; other site 203124002750 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 203124002751 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 203124002752 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 203124002753 Peptidase M16C associated; Region: M16C_assoc; pfam08367 203124002754 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 203124002755 Uncharacterised protein family UPF0547; Region: UPF0547; pfam10571 203124002756 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 203124002757 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124002758 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 203124002759 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 203124002760 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 203124002761 FeS/SAM binding site; other site 203124002762 HemN C-terminal region; Region: HemN_C; pfam06969 203124002763 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 203124002764 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 203124002765 putative active site [active] 203124002766 TRAM domain; Region: TRAM; cl01282 203124002767 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124002768 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 203124002769 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 203124002770 Probable Catalytic site [active] 203124002771 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124002772 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 203124002773 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 203124002774 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 203124002775 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 203124002776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124002777 ATP binding site [chemical binding]; other site 203124002778 Mg2+ binding site [ion binding]; other site 203124002779 G-X-G motif; other site 203124002780 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 203124002781 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 203124002782 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 203124002783 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 203124002784 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 203124002785 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 203124002786 DNA binding residues [nucleotide binding] 203124002787 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 203124002788 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 203124002789 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124002790 YacP-like NYN domain; Region: NYN_YacP; cl01491 203124002791 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 203124002792 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 203124002793 Walker A/P-loop; other site 203124002794 ATP binding site [chemical binding]; other site 203124002795 Q-loop/lid; other site 203124002796 ABC transporter signature motif; other site 203124002797 Walker B; other site 203124002798 D-loop; other site 203124002799 H-loop/switch region; other site 203124002800 hypothetical protein; Provisional; Region: PRK13683 203124002801 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 203124002802 D1 interface; other site 203124002803 chlorophyll binding site; other site 203124002804 pheophytin binding site; other site 203124002805 beta carotene binding site; other site 203124002806 cytochrome b559 beta interface; other site 203124002807 quinone binding site; other site 203124002808 cytochrome b559 alpha interface; other site 203124002809 protein J interface; other site 203124002810 protein H interface; other site 203124002811 protein X interface; other site 203124002812 core light harvesting protein interface; other site 203124002813 protein L interface; other site 203124002814 CP43 interface; other site 203124002815 protein T interface; other site 203124002816 Fe binding site [ion binding]; other site 203124002817 protein M interface; other site 203124002818 Mn-stabilizing polypeptide interface; other site 203124002819 bromide binding site; other site 203124002820 cytochrome c-550 interface; other site 203124002821 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 203124002822 aromatic arch; other site 203124002823 DCoH dimer interaction site [polypeptide binding]; other site 203124002824 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 203124002825 DCoH tetramer interaction site [polypeptide binding]; other site 203124002826 substrate binding site [chemical binding]; other site 203124002827 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124002828 GAF domain; Region: GAF; cl00853 203124002829 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 203124002830 Zn2+ binding site [ion binding]; other site 203124002831 Mg2+ binding site [ion binding]; other site 203124002832 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 203124002833 S-layer homology domain; Region: SLH; pfam00395 203124002834 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 203124002835 cysteine synthases; Region: cysKM; TIGR01136 203124002836 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 203124002837 dimer interface [polypeptide binding]; other site 203124002838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124002839 catalytic residue [active] 203124002840 rod shape-determining protein MreB; Provisional; Region: PRK13930 203124002841 chaperone protein HscA; Provisional; Region: hscA; PRK01433 203124002842 Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]; Region: COG5354 203124002843 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 203124002844 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 203124002845 HSP70 interaction site [polypeptide binding]; other site 203124002846 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124002847 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 203124002848 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 203124002849 metal ion-dependent adhesion site (MIDAS); other site 203124002850 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 203124002851 oligomer interface [polypeptide binding]; other site 203124002852 active site residues [active] 203124002853 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 203124002854 oligomer interface [polypeptide binding]; other site 203124002855 active site residues [active] 203124002856 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 203124002857 HSP70 interaction site [polypeptide binding]; other site 203124002858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002859 binding surface 203124002860 TPR motif; other site 203124002861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124002862 binding surface 203124002863 TPR motif; other site 203124002864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124002865 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 203124002866 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 203124002867 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 203124002868 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124002869 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 203124002870 Membrane protein of unknown function; Region: DUF360; cl00850 203124002871 GTP-binding protein YchF; Reviewed; Region: PRK09601 203124002872 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 203124002873 G1 box; other site 203124002874 GTP/Mg2+ binding site [chemical binding]; other site 203124002875 Switch I region; other site 203124002876 G2 box; other site 203124002877 Switch II region; other site 203124002878 G3 box; other site 203124002879 G4 box; other site 203124002880 G5 box; other site 203124002881 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 203124002882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124002883 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 203124002884 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and...; Region: Orn_deC_like; cd00615 203124002885 homodimer interface [polypeptide binding]; other site 203124002886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124002887 catalytic residue [active] 203124002888 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 203124002889 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124002890 Integrase core domain; Region: rve; cl01316 203124002891 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 203124002892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124002893 S-adenosylmethionine binding site [chemical binding]; other site 203124002894 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 203124002895 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 203124002896 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 203124002897 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 203124002898 RNA binding surface [nucleotide binding]; other site 203124002899 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 203124002900 active site 203124002901 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 203124002902 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 203124002903 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 203124002904 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 203124002905 StbA protein; Region: StbA; pfam06406 203124002906 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 203124002907 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 203124002908 metal-binding site [ion binding] 203124002909 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 203124002910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 203124002911 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 203124002912 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 203124002913 Walker A/P-loop; other site 203124002914 ATP binding site [chemical binding]; other site 203124002915 Q-loop/lid; other site 203124002916 ABC transporter signature motif; other site 203124002917 Walker B; other site 203124002918 D-loop; other site 203124002919 H-loop/switch region; other site 203124002920 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 203124002921 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 203124002922 Catalytic site [active] 203124002923 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 203124002924 active site 203124002925 elongation factor P; Validated; Region: PRK00529 203124002926 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 203124002927 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 203124002928 RNA binding site [nucleotide binding]; other site 203124002929 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 203124002930 RNA binding site [nucleotide binding]; other site 203124002931 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 203124002932 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 203124002933 carboxyltransferase (CT) interaction site; other site 203124002934 biotinylation site [posttranslational modification]; other site 203124002935 Sporulation and spore germination; Region: Germane; pfam10646 203124002936 prolyl-tRNA synthetase; Provisional; Region: PRK09194 203124002937 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 203124002938 dimer interface [polypeptide binding]; other site 203124002939 motif 1; other site 203124002940 active site 203124002941 motif 2; other site 203124002942 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 203124002943 putative deacylase active site [active] 203124002944 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 203124002945 active site 203124002946 motif 3; other site 203124002947 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 203124002948 anticodon binding site; other site 203124002949 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_37; cd04696 203124002950 nudix motif; other site 203124002951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 203124002952 ornithine carbamoyltransferase; Provisional; Region: PRK00779 203124002953 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 203124002954 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 203124002955 Sodium:solute symporter family; Region: SSF; cl00456 203124002956 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 203124002957 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 203124002958 FMN binding site [chemical binding]; other site 203124002959 active site 203124002960 catalytic residues [active] 203124002961 substrate binding site [chemical binding]; other site 203124002962 fumarate hydratase; Reviewed; Region: fumC; PRK00485 203124002963 Class II fumarases; Region: Fumarase_classII; cd01362 203124002964 active site 203124002965 tetramer interface [polypeptide binding]; other site 203124002966 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124002967 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 203124002968 DNA-binding interface [nucleotide binding]; DNA binding site 203124002969 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124002970 CHAT domain; Region: CHAT; cl02083 203124002971 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 203124002972 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 203124002973 Ligand binding site [chemical binding]; other site 203124002974 Putative Catalytic site [active] 203124002975 DXD motif; other site 203124002976 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124002977 Thioesterase domain; Region: Thioesterase; pfam00975 203124002978 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 203124002979 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 203124002980 NADP binding site [chemical binding]; other site 203124002981 active site 203124002982 putative substrate binding site [chemical binding]; other site 203124002983 Cupin domain; Region: Cupin_2; cl09118 203124002984 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 203124002985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124002986 S-adenosylmethionine binding site [chemical binding]; other site 203124002987 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 203124002988 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 203124002989 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 203124002990 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 203124002991 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 203124002992 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 203124002993 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 203124002994 ligand binding site [chemical binding]; other site 203124002995 flexible hinge region; other site 203124002996 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 203124002997 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cd02259 203124002998 putative active site [active] 203124002999 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 203124003000 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 203124003001 Walker A/P-loop; other site 203124003002 ATP binding site [chemical binding]; other site 203124003003 Q-loop/lid; other site 203124003004 ABC transporter signature motif; other site 203124003005 Walker B; other site 203124003006 D-loop; other site 203124003007 H-loop/switch region; other site 203124003008 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 203124003009 PPIC-type PPIASE domain; Region: Rotamase; cl08278 203124003010 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124003011 long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584 203124003012 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124003013 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 203124003014 putative ADP-binding pocket [chemical binding]; other site 203124003015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124003016 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124003017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 203124003018 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 203124003019 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 203124003020 Probable Catalytic site [active] 203124003021 metal binding site [ion binding]; metal-binding site 203124003022 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 203124003023 Probable Catalytic site [active] 203124003024 metal binding site [ion binding]; metal-binding site 203124003025 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124003026 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 203124003027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124003028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124003029 S-adenosylmethionine binding site [chemical binding]; other site 203124003030 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 203124003031 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 203124003032 Walker A/P-loop; other site 203124003033 ATP binding site [chemical binding]; other site 203124003034 Q-loop/lid; other site 203124003035 ABC transporter signature motif; other site 203124003036 Walker B; other site 203124003037 D-loop; other site 203124003038 H-loop/switch region; other site 203124003039 ABC-2 type transporter; Region: ABC2_membrane; cl11417 203124003040 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 203124003041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124003042 Walker A motif; other site 203124003043 ATP binding site [chemical binding]; other site 203124003044 Walker B motif; other site 203124003045 arginine finger; other site 203124003046 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 203124003047 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124003048 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 203124003049 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124003050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124003051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124003052 S-adenosylmethionine binding site [chemical binding]; other site 203124003053 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 203124003054 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 203124003055 catalytic residue [active] 203124003056 lysine decarboxylase CadA; Provisional; Region: PRK15400 203124003057 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 203124003058 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 203124003059 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124003060 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 203124003061 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 203124003062 active site 203124003063 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 203124003064 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 203124003065 substrate binding site [chemical binding]; other site 203124003066 dimer interface [polypeptide binding]; other site 203124003067 catalytic triad [active] 203124003068 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 203124003069 dihydropteroate synthase; Region: DHPS; TIGR01496 203124003070 substrate binding pocket [chemical binding]; other site 203124003071 dimer interface [polypeptide binding]; other site 203124003072 inhibitor binding site; inhibition site 203124003073 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 203124003074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124003075 dimer interface [polypeptide binding]; other site 203124003076 conserved gate region; other site 203124003077 ABC-ATPase subunit interface; other site 203124003078 tyramine oxidase; Provisional; Region: tynA; PRK11504 203124003079 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 203124003080 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 203124003081 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 203124003082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 203124003083 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124003084 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124003085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124003086 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 203124003087 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 203124003088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 203124003089 binding surface 203124003090 TPR motif; other site 203124003091 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124003092 recombination protein RecR; Reviewed; Region: recR; PRK00076 203124003093 RecR protein; Region: RecR; pfam02132 203124003094 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 203124003095 putative active site [active] 203124003096 putative metal-binding site [ion binding]; other site 203124003097 tetramer interface [polypeptide binding]; other site 203124003098 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 203124003099 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family...; Region: NanE; cd04729 203124003100 putative active site cavity [active] 203124003101 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124003102 GAF domain; Region: GAF; cl00853 203124003103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 203124003104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124003105 dimer interface [polypeptide binding]; other site 203124003106 phosphorylation site [posttranslational modification] 203124003107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124003108 ATP binding site [chemical binding]; other site 203124003109 Mg2+ binding site [ion binding]; other site 203124003110 G-X-G motif; other site 203124003111 Response regulator receiver domain; Region: Response_reg; pfam00072 203124003112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124003113 active site 203124003114 phosphorylation site [posttranslational modification] 203124003115 intermolecular recognition site; other site 203124003116 dimerization interface [polypeptide binding]; other site 203124003117 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124003118 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124003119 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 203124003120 DHH family; Region: DHH; pfam01368 203124003121 FOG: CBS domain [General function prediction only]; Region: COG0517 203124003122 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 203124003123 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 203124003124 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 203124003125 active site 203124003126 NTP binding site [chemical binding]; other site 203124003127 metal binding triad [ion binding]; metal-binding site 203124003128 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 203124003129 putative active site [active] 203124003130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 203124003131 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 203124003132 Probable transposase; Region: OrfB_IS605; pfam01385 203124003133 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 203124003134 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 203124003135 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 203124003136 G1 box; other site 203124003137 GTP/Mg2+ binding site [chemical binding]; other site 203124003138 G2 box; other site 203124003139 Switch I region; other site 203124003140 G3 box; other site 203124003141 Switch II region; other site 203124003142 G4 box; other site 203124003143 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 203124003144 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 203124003145 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 203124003146 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 203124003147 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124003148 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 203124003149 YCF9; Region: Ycf9; cl09269 203124003150 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 203124003151 homopentamer interface [polypeptide binding]; other site 203124003152 active site 203124003153 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 203124003154 Fatty acid desaturase; Region: FA_desaturase; pfam00487 203124003155 Di-iron ligands [ion binding]; other site 203124003156 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 203124003157 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 203124003158 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 203124003159 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 203124003160 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 203124003161 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124003162 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124003163 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124003164 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 203124003165 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124003166 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 203124003167 ligand binding site [chemical binding]; other site 203124003168 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 203124003169 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 203124003170 putative ligand binding site [chemical binding]; other site 203124003171 WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998 203124003172 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 203124003173 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 203124003174 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 203124003175 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 203124003176 active site 203124003177 dimer interface [polypeptide binding]; other site 203124003178 motif 1; other site 203124003179 motif 2; other site 203124003180 motif 3; other site 203124003181 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 203124003182 anticodon binding site; other site 203124003183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124003184 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 203124003185 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124003186 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 203124003187 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 203124003188 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 203124003189 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 203124003190 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124003191 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124003192 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 203124003193 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124003194 Walker A motif; other site 203124003195 ATP binding site [chemical binding]; other site 203124003196 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 203124003197 thioester formation/cholesterol transfer; other site 203124003198 protein-splicing catalytic site; other site 203124003199 replicative DNA helicase; Validated; Region: PRK07773 203124003200 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl09966 203124003201 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 203124003202 Walker B motif; other site 203124003203 DNA binding loops [nucleotide binding] 203124003204 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 203124003205 protein-splicing catalytic site; other site 203124003206 thioester formation/cholesterol transfer; other site 203124003207 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124003208 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 203124003209 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 203124003210 putative active site [active] 203124003211 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 203124003212 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 203124003213 sensory histidine kinase AtoS; Provisional; Region: PRK11360 203124003214 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 203124003215 dimerization interface [polypeptide binding]; other site 203124003216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124003217 dimer interface [polypeptide binding]; other site 203124003218 phosphorylation site [posttranslational modification] 203124003219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124003220 ATP binding site [chemical binding]; other site 203124003221 Mg2+ binding site [ion binding]; other site 203124003222 G-X-G motif; other site 203124003223 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 203124003224 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 203124003225 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 203124003226 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 203124003227 Beta-lactamase; Region: Beta-lactamase; cl01009 203124003228 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 203124003229 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 203124003230 Cysteine dioxygenase type I; Region: CDO_I; cl02350 203124003231 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 203124003232 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 203124003233 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 203124003234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124003235 S-adenosylmethionine binding site [chemical binding]; other site 203124003236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124003237 S-adenosylmethionine binding site [chemical binding]; other site 203124003238 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 203124003239 Probable Catalytic site [active] 203124003240 metal binding site [ion binding]; metal-binding site 203124003241 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124003242 active site 203124003243 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 203124003244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124003245 S-adenosylmethionine binding site [chemical binding]; other site 203124003246 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124003247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124003248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124003249 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 203124003250 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 203124003251 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124003252 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 203124003253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124003254 S-adenosylmethionine binding site [chemical binding]; other site 203124003255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003256 TPR motif; other site 203124003257 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 203124003258 binding surface 203124003259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003260 binding surface 203124003261 TPR motif; other site 203124003262 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 203124003263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003264 binding surface 203124003265 TPR motif; other site 203124003266 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 203124003267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003268 binding surface 203124003269 TPR motif; other site 203124003270 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003271 binding surface 203124003272 TPR motif; other site 203124003273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003274 binding surface 203124003275 TPR motif; other site 203124003276 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 203124003277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003278 binding surface 203124003279 TPR motif; other site 203124003280 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124003281 active site 203124003282 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124003283 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 203124003284 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 203124003285 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 203124003286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124003287 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 203124003288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 203124003289 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 203124003290 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 203124003291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003292 binding surface 203124003293 TPR motif; other site 203124003294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003295 binding surface 203124003296 TPR motif; other site 203124003297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003298 binding surface 203124003299 TPR motif; other site 203124003300 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 203124003301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003302 binding surface 203124003303 TPR motif; other site 203124003304 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003305 binding surface 203124003306 TPR motif; other site 203124003307 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 203124003308 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 203124003309 RES domain; Region: RES; cl02411 203124003310 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 203124003311 catalytic residues [active] 203124003312 NIL domain; Region: NIL; pfam09383 203124003313 hypothetical protein; Provisional; Region: PRK13795 203124003314 shikimate kinase; Reviewed; Region: aroK; PRK00131 203124003315 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 203124003316 ADP binding site [chemical binding]; other site 203124003317 magnesium binding site [ion binding]; other site 203124003318 putative shikimate binding site; other site 203124003319 Flavoprotein; Region: Flavoprotein; cl08021 203124003320 Flavoprotein; Region: Flavoprotein; cl08021 203124003321 Exoribonuclease R [Transcription]; Region: VacB; COG0557 203124003322 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 203124003323 RNB domain; Region: RNB; pfam00773 203124003324 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 203124003325 RNA binding site [nucleotide binding]; other site 203124003326 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 203124003327 oligomer interface [polypeptide binding]; other site 203124003328 active site residues [active] 203124003329 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 203124003330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 203124003331 FeS/SAM binding site; other site 203124003332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003333 binding surface 203124003334 TPR motif; other site 203124003335 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124003336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003337 binding surface 203124003338 TPR motif; other site 203124003339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003340 binding surface 203124003341 TPR motif; other site 203124003342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003343 binding surface 203124003344 TPR motif; other site 203124003345 conserved hypothetical protein; Region: TIGR02466 203124003346 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 203124003347 dimer interface [polypeptide binding]; other site 203124003348 substrate binding site [chemical binding]; other site 203124003349 metal binding sites [ion binding]; metal-binding site 203124003350 putative glycosyl transferase; Provisional; Region: PRK10307 203124003351 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 203124003352 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 203124003353 anti sigma factor interaction site; other site 203124003354 regulatory phosphorylation site [posttranslational modification]; other site 203124003355 Bacterial sugar transferase; Region: Bac_transf; cl00939 203124003356 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 203124003357 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 203124003358 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls...; Region: Pchlide_reductase_N; cd01979 203124003359 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 203124003360 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 203124003361 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB...; Region: Bchl_like; cd02032 203124003362 P-loop; other site 203124003363 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 203124003364 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 203124003365 Surface antigen; Region: Bac_surface_Ag; cl03097 203124003366 FOG: WD40-like repeat [Function unknown]; Region: COG1520 203124003367 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 203124003368 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 203124003369 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 203124003370 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 203124003371 substrate binding site [chemical binding]; other site 203124003372 metal binding site [ion binding]; metal-binding site 203124003373 Oligomer interface [polypeptide binding]; other site 203124003374 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 203124003375 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 203124003376 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 203124003377 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 203124003378 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 203124003379 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 203124003380 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 203124003381 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 203124003382 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 203124003383 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 203124003384 putative nucleic acid binding region [nucleotide binding]; other site 203124003385 G-X-X-G motif; other site 203124003386 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 203124003387 RNA binding site [nucleotide binding]; other site 203124003388 domain interface; other site 203124003389 SNF2 Helicase protein; Region: DUF3670; pfam12419 203124003390 Probable chromatin-remodeling complex ATPase chain; Provisional; Region: PLN03142 203124003391 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 203124003392 translation initiation factor IF-2; Provisional; Region: PRK14845 203124003393 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 203124003394 protein-splicing catalytic site; other site 203124003395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124003396 putative Mg++ binding site [ion binding]; other site 203124003397 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203124003398 nucleotide binding region [chemical binding]; other site 203124003399 ATP-binding site [chemical binding]; other site 203124003400 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124003401 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124003402 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 203124003403 putative active site [active] 203124003404 Microtubule-associated protein Bicaudal-D; Region: BicD; pfam09730 203124003405 CHAT domain; Region: CHAT; cl02083 203124003406 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 203124003407 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 203124003408 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 203124003409 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 203124003410 Walker A/P-loop; other site 203124003411 ATP binding site [chemical binding]; other site 203124003412 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 203124003413 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 203124003414 ABC transporter signature motif; other site 203124003415 Walker B; other site 203124003416 D-loop; other site 203124003417 H-loop/switch region; other site 203124003418 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 203124003419 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 203124003420 NaMN:DMB phosphoribosyltransferase [Coenzyme metabolism]; Region: CobT; COG2038 203124003421 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 203124003422 putative dimer interface [polypeptide binding]; other site 203124003423 active site pocket [active] 203124003424 putative cataytic base [active] 203124003425 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 203124003426 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 203124003427 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 203124003428 ligand binding site [chemical binding]; other site 203124003429 flexible hinge region; other site 203124003430 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 203124003431 V-type ATP synthase subunit I; Validated; Region: PRK05771 203124003432 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 203124003433 Gram-negative bacterial tonB protein; Region: TonB; cl10048 203124003434 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 203124003435 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 203124003436 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 203124003437 metal-binding site [ion binding] 203124003438 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 203124003439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 203124003440 thymidylate kinase; Validated; Region: tmk; PRK00698 203124003441 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 203124003442 TMP-binding site; other site 203124003443 ATP-binding site [chemical binding]; other site 203124003444 DNA polymerase III subunit delta'; Validated; Region: PRK07399 203124003445 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124003446 Domain of unknown function (DUF309); Region: DUF309; cl00667 203124003447 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 203124003448 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124003449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003450 binding surface 203124003451 TPR motif; other site 203124003452 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 203124003453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003454 binding surface 203124003455 TPR motif; other site 203124003456 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124003457 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 203124003458 Protein of unknown function DUF58; Region: DUF58; pfam01882 203124003459 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 203124003460 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 203124003461 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124003462 ATP binding site [chemical binding]; other site 203124003463 putative Mg++ binding site [ion binding]; other site 203124003464 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203124003465 nucleotide binding region [chemical binding]; other site 203124003466 ATP-binding site [chemical binding]; other site 203124003467 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 203124003468 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 203124003469 active site 203124003470 (T/H)XGH motif; other site 203124003471 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124003472 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 203124003473 putative multimerization interface [polypeptide binding]; other site 203124003474 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 203124003475 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 203124003476 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 203124003477 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 203124003478 4Fe-4S binding domain; Region: Fer4; cl02805 203124003479 NADH dehydrogenase; Region: NADHdh; cl00469 203124003480 citrate synthase; Provisional; Region: PRK14036 203124003481 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the...; Region: citrate_synt_like_1_1; cd06112 203124003482 dimer interface [polypeptide binding]; other site 203124003483 active site 203124003484 citrylCoA binding site [chemical binding]; other site 203124003485 oxalacetate/citrate binding site [chemical binding]; other site 203124003486 coenzyme A binding site [chemical binding]; other site 203124003487 catalytic triad [active] 203124003488 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 203124003489 catalytic core [active] 203124003490 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 203124003491 active site 203124003492 alanine racemase; Reviewed; Region: alr; PRK00053 203124003493 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 203124003494 active site 203124003495 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 203124003496 dimer interface [polypeptide binding]; other site 203124003497 substrate binding site [chemical binding]; other site 203124003498 catalytic residues [active] 203124003499 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 203124003500 RNA/DNA hybrid binding site [nucleotide binding]; other site 203124003501 active site 203124003502 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124003503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003504 binding surface 203124003505 TPR motif; other site 203124003506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003507 binding surface 203124003508 TPR motif; other site 203124003509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003510 binding surface 203124003511 TPR motif; other site 203124003512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003513 binding surface 203124003514 TPR motif; other site 203124003515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003516 binding surface 203124003517 TPR motif; other site 203124003518 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 203124003519 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal...; Region: IDI-2_FMN; cd02811 203124003520 homotetramer interface [polypeptide binding]; other site 203124003521 FMN binding site [chemical binding]; other site 203124003522 homodimer contacts [polypeptide binding]; other site 203124003523 putative active site [active] 203124003524 putative substrate binding site [chemical binding]; other site 203124003525 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 203124003526 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 203124003527 tandem repeat interface [polypeptide binding]; other site 203124003528 oligomer interface [polypeptide binding]; other site 203124003529 active site residues [active] 203124003530 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 203124003531 tandem repeat interface [polypeptide binding]; other site 203124003532 oligomer interface [polypeptide binding]; other site 203124003533 active site residues [active] 203124003534 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 203124003535 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 203124003536 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 203124003537 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 203124003538 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 203124003539 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 203124003540 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 203124003541 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 203124003542 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 203124003543 P-loop; other site 203124003544 Magnesium ion binding site [ion binding]; other site 203124003545 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 203124003546 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 203124003547 YCII-related domain; Region: YCII; cl00999 203124003548 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 203124003549 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 203124003550 Predicted methyltransferases [General function prediction only]; Region: COG0313 203124003551 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 203124003552 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 203124003553 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 203124003554 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124003555 Competence protein A; Region: Competence_A; pfam11104 203124003556 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 203124003557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124003558 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 203124003559 Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796 203124003560 Secretin and TonB N terminus short domain; Region: STN; pfam07660 203124003561 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 203124003562 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 203124003563 IHF dimer interface [polypeptide binding]; other site 203124003564 IHF - DNA interface [nucleotide binding]; other site 203124003565 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 203124003566 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 203124003567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124003568 homodimer interface [polypeptide binding]; other site 203124003569 catalytic residue [active] 203124003570 mercuric reductase; Validated; Region: PRK06370 203124003571 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124003572 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 203124003573 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 203124003574 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 203124003575 putative active site [active] 203124003576 putative metal binding site [ion binding]; other site 203124003577 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 203124003578 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 203124003579 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 203124003580 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 203124003581 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 203124003582 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 203124003583 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 203124003584 putative active site [active] 203124003585 catalytic site [active] 203124003586 putative substrate binding site [chemical binding]; other site 203124003587 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124003588 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 203124003589 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124003590 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 203124003591 protein binding site [polypeptide binding]; other site 203124003592 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 203124003593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 203124003594 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124003595 active site 203124003596 ATP binding site [chemical binding]; other site 203124003597 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124003598 substrate binding site [chemical binding]; other site 203124003599 activation loop (A-loop); other site 203124003600 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124003601 structural tetrad; other site 203124003602 Surface antigen; Region: Bac_surface_Ag; cl03097 203124003603 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 203124003604 Predicted amidohydrolase [General function prediction only]; Region: COG0388 203124003605 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 203124003606 putative active site [active] 203124003607 catalytic triad [active] 203124003608 dimer interface [polypeptide binding]; other site 203124003609 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 203124003610 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 203124003611 UGMP family protein; Validated; Region: PRK09604 203124003612 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 203124003613 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 203124003614 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203124003615 Coenzyme A binding pocket [chemical binding]; other site 203124003616 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 203124003617 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203124003618 Coenzyme A binding pocket [chemical binding]; other site 203124003619 Tic22-like family; Region: Tic22; cl04468 203124003620 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 203124003621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124003622 S-adenosylmethionine binding site [chemical binding]; other site 203124003623 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 203124003624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 203124003625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124003626 ATP binding site [chemical binding]; other site 203124003627 Mg2+ binding site [ion binding]; other site 203124003628 G-X-G motif; other site 203124003629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 203124003630 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 203124003631 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 203124003632 tetramer interface [polypeptide binding]; other site 203124003633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124003634 catalytic residue [active] 203124003635 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124003636 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cl03075 203124003637 hypothetical protein; Provisional; Region: PRK09866 203124003638 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 203124003639 G1 box; other site 203124003640 GTP/Mg2+ binding site [chemical binding]; other site 203124003641 Switch I region; other site 203124003642 G2 box; other site 203124003643 Switch II region; other site 203124003644 G3 box; other site 203124003645 G4 box; other site 203124003646 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 203124003647 GTP/Mg2+ binding site [chemical binding]; other site 203124003648 Switch I region; other site 203124003649 G2 box; other site 203124003650 Switch II region; other site 203124003651 G3 box; other site 203124003652 G4 box; other site 203124003653 G5 box; other site 203124003654 Hsp70 protein; Region: HSP70; pfam00012 203124003655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003656 binding surface 203124003657 TPR motif; other site 203124003658 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124003659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003660 binding surface 203124003661 TPR motif; other site 203124003662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003663 binding surface 203124003664 TPR motif; other site 203124003665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003666 binding surface 203124003667 TPR motif; other site 203124003668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003669 binding surface 203124003670 TPR motif; other site 203124003671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003672 binding surface 203124003673 TPR motif; other site 203124003674 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 203124003675 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 203124003676 catalytic motif [active] 203124003677 Zn binding site [ion binding]; other site 203124003678 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 203124003679 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 203124003680 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 203124003681 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 203124003682 non-specific DNA interactions [nucleotide binding]; other site 203124003683 DNA binding site [nucleotide binding] 203124003684 sequence specific DNA binding site [nucleotide binding]; other site 203124003685 putative cAMP binding site [chemical binding]; other site 203124003686 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 203124003687 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 203124003688 Photosystem II protein; Region: PSII; cl08223 203124003689 Protein kinase domain; Region: Pkinase; pfam00069 203124003690 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124003691 active site 203124003692 ATP binding site [chemical binding]; other site 203124003693 substrate binding site [chemical binding]; other site 203124003694 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 203124003695 substrate binding site [chemical binding]; other site 203124003696 activation loop (A-loop); other site 203124003697 activation loop (A-loop); other site 203124003698 V-type ATP synthase subunit I; Validated; Region: PRK05771 203124003699 CHASE domain; Region: CHASE; cl01369 203124003700 sensory histidine kinase AtoS; Provisional; Region: PRK11360 203124003701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124003702 ATP binding site [chemical binding]; other site 203124003703 Mg2+ binding site [ion binding]; other site 203124003704 G-X-G motif; other site 203124003705 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 203124003706 Precorrin-8X methylmutase; Region: CbiC; pfam02570 203124003707 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 203124003708 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 203124003709 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124003710 ATP binding site [chemical binding]; other site 203124003711 putative Mg++ binding site [ion binding]; other site 203124003712 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203124003713 nucleotide binding region [chemical binding]; other site 203124003714 ATP-binding site [chemical binding]; other site 203124003715 TRCF domain; Region: TRCF; pfam03461 203124003716 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 203124003717 active site 203124003718 oxyanion hole [active] 203124003719 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 203124003720 active site 203124003721 oxyanion hole [active] 203124003722 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 203124003723 active site 203124003724 oxyanion hole [active] 203124003725 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 203124003726 active site 203124003727 oxyanion hole [active] 203124003728 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 203124003729 active site 203124003730 oxyanion hole [active] 203124003731 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 203124003732 active site 203124003733 oxyanion hole [active] 203124003734 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 203124003735 active site flap/lid [active] 203124003736 nucleophilic elbow; other site 203124003737 catalytic triad [active] 203124003738 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 203124003739 active site 203124003740 intersubunit interface [polypeptide binding]; other site 203124003741 catalytic residue [active] 203124003742 Leucine carboxyl methyltransferase; Region: LCM; cl01306 203124003743 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124003744 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124003745 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124003746 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 203124003747 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 203124003748 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 203124003749 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 203124003750 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 203124003751 HIGH motif; other site 203124003752 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 203124003753 active site 203124003754 KMSKS motif; other site 203124003755 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 203124003756 tRNA binding surface [nucleotide binding]; other site 203124003757 anticodon binding site; other site 203124003758 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 203124003759 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 203124003760 tRNA binding surface [nucleotide binding]; other site 203124003761 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 203124003762 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 203124003763 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 203124003764 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 203124003765 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 203124003766 MatE; Region: MatE; pfam01554 203124003767 Protein of unknown function (DUF429); Region: DUF429; cl12046 203124003768 V-type ATP synthase subunit I; Validated; Region: PRK05771 203124003769 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 203124003770 substrate binding site [chemical binding]; other site 203124003771 active site 203124003772 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 203124003773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124003774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003775 binding surface 203124003776 TPR motif; other site 203124003777 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 203124003778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003779 binding surface 203124003780 TPR motif; other site 203124003781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003782 binding surface 203124003783 TPR motif; other site 203124003784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003785 binding surface 203124003786 TPR motif; other site 203124003787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003788 binding surface 203124003789 TPR motif; other site 203124003790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003791 binding surface 203124003792 TPR motif; other site 203124003793 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 203124003794 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124003795 active site 203124003796 ATP binding site [chemical binding]; other site 203124003797 substrate binding site [chemical binding]; other site 203124003798 activation loop (A-loop); other site 203124003799 GUN4-like; Region: GUN4; pfam05419 203124003800 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124003801 active site 203124003802 ATP binding site [chemical binding]; other site 203124003803 substrate binding site [chemical binding]; other site 203124003804 activation loop (A-loop); other site 203124003805 GUN4-like; Region: GUN4; pfam05419 203124003806 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 203124003807 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 203124003808 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 203124003809 recombination protein F; Reviewed; Region: recF; PRK00064 203124003810 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 203124003811 Walker A/P-loop; other site 203124003812 ATP binding site [chemical binding]; other site 203124003813 Q-loop/lid; other site 203124003814 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124003815 ABC transporter signature motif; other site 203124003816 Walker B; other site 203124003817 D-loop; other site 203124003818 H-loop/switch region; other site 203124003819 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124003820 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124003821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124003822 Walker A motif; other site 203124003823 ATP binding site [chemical binding]; other site 203124003824 Walker B motif; other site 203124003825 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124003826 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124003827 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 203124003828 photosystem II protein Psb27; Provisional; Region: PLN00064; cl11841 203124003829 Uncharacterised BCR, COG1649; Region: DUF187; pfam02638 203124003830 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 203124003831 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 203124003832 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 203124003833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124003834 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 203124003835 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 203124003836 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 203124003837 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 203124003838 Walker A motif; other site 203124003839 ATP binding site [chemical binding]; other site 203124003840 Walker B motif; other site 203124003841 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 203124003842 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 203124003843 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 203124003844 Walker A motif; other site 203124003845 ATP binding site [chemical binding]; other site 203124003846 Walker B motif; other site 203124003847 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 203124003848 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 203124003849 dimer interface [polypeptide binding]; other site 203124003850 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 203124003851 molecular chaperone DnaK; Provisional; Region: PRK13411 203124003852 chaperone protein DnaJ; Provisional; Region: PRK14293 203124003853 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 203124003854 HSP70 interaction site [polypeptide binding]; other site 203124003855 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 203124003856 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 203124003857 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 203124003858 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 203124003859 CPxP motif; other site 203124003860 GTPase RsgA; Reviewed; Region: PRK12289 203124003861 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 203124003862 GTPase/OB domain interface [polypeptide binding]; other site 203124003863 GTPase/Zn-binding domain interface [polypeptide binding]; other site 203124003864 GTP/Mg2+ binding site [chemical binding]; other site 203124003865 G4 box; other site 203124003866 G5 box; other site 203124003867 G1 box; other site 203124003868 Switch I region; other site 203124003869 G2 box; other site 203124003870 G3 box; other site 203124003871 Switch II region; other site 203124003872 tocopherol O-methyltransferase; Region: PLN02244 203124003873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124003874 S-adenosylmethionine binding site [chemical binding]; other site 203124003875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124003876 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 203124003877 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 203124003878 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 203124003879 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 203124003880 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 203124003881 heme binding site [chemical binding]; other site 203124003882 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 203124003883 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 203124003884 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 203124003885 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 203124003886 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 203124003887 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 203124003888 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 203124003889 substrate binding site [chemical binding]; other site 203124003890 glutamase interaction surface [polypeptide binding]; other site 203124003891 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 203124003892 HSP70 interaction site [polypeptide binding]; other site 203124003893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124003894 binding surface 203124003895 TPR motif; other site 203124003896 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 203124003897 Yip1 domain; Region: Yip1; cl12048 203124003898 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 203124003899 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 203124003900 putative active site [active] 203124003901 substrate binding site [chemical binding]; other site 203124003902 putative cosubstrate binding site; other site 203124003903 catalytic site [active] 203124003904 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 203124003905 substrate binding site [chemical binding]; other site 203124003906 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 203124003907 ATP-NAD kinase; Region: NAD_kinase; pfam01513 203124003908 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 203124003909 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 203124003910 Arylesterase; Region: Arylesterase; pfam01731 203124003911 Uncharacterized conserved protein [Function unknown]; Region: COG3391 203124003912 Calx-beta domain; Region: Calx-beta; cl02522 203124003913 Calx-beta domain; Region: Calx-beta; cl02522 203124003914 Calx-beta domain; Region: Calx-beta; cl02522 203124003915 Calx-beta domain; Region: Calx-beta; cl02522 203124003916 Calx-beta domain; Region: Calx-beta; cl02522 203124003917 Calx-beta domain; Region: Calx-beta; cl02522 203124003918 Uncharacterized conserved protein [Function unknown]; Region: COG3391 203124003919 Calx-beta domain; Region: Calx-beta; cl02522 203124003920 Calx-beta domain; Region: Calx-beta; cl02522 203124003921 Calx-beta domain; Region: Calx-beta; cl02522 203124003922 Survival protein SurE; Region: SurE; cl00448 203124003923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124003924 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 203124003925 Subunit I/III interface [polypeptide binding]; other site 203124003926 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 203124003927 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 203124003928 D-pathway; other site 203124003929 Subunit I/VIIc interface [polypeptide binding]; other site 203124003930 Subunit I/IV interface [polypeptide binding]; other site 203124003931 Subunit I/II interface [polypeptide binding]; other site 203124003932 Low-spin heme (heme a) binding site [chemical binding]; other site 203124003933 Subunit I/III interface [polypeptide binding]; other site 203124003934 Subunit I/VIIa interface [polypeptide binding]; other site 203124003935 Subunit I/VIa interface [polypeptide binding]; other site 203124003936 Dimer interface; other site 203124003937 Putative water exit pathway; other site 203124003938 Binuclear center (heme a3/CuB) [ion binding]; other site 203124003939 K-pathway; other site 203124003940 Subunit I/Vb interface [polypeptide binding]; other site 203124003941 Putative proton exit pathway; other site 203124003942 Subunit I/VIb interface; other site 203124003943 Subunit I/VIc interface [polypeptide binding]; other site 203124003944 Electron transfer pathway; other site 203124003945 Subunit I/VIIIb interface [polypeptide binding]; other site 203124003946 Subunit I/VIIb interface [polypeptide binding]; other site 203124003947 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 203124003948 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 203124003949 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 203124003950 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 203124003951 UbiA prenyltransferase family; Region: UbiA; cl00337 203124003952 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 203124003953 Archaeal ATPase; Region: Arch_ATPase; pfam01637 203124003954 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 203124003955 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 203124003956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 203124003957 TspO/MBR family; Region: TspO_MBR; cl01379 203124003958 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 203124003959 active site 203124003960 putative lithium-binding site [ion binding]; other site 203124003961 substrate binding site [chemical binding]; other site 203124003962 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 203124003963 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 203124003964 Oxygen evolving enhancer protein 3 (PsbQ); Region: PsbQ; cl05363 203124003965 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 203124003966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124003967 NAD(P) binding site [chemical binding]; other site 203124003968 active site 203124003969 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 203124003970 active site 203124003971 nucleophile elbow; other site 203124003972 alpha/beta hydrolase fold protein; Provisional; Region: PLN03084 203124003973 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124003974 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 203124003975 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 203124003976 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 203124003977 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium...; Region: Rieske_cytochrome_b6f; cd03471 203124003978 cytochrome b subunit interaction site [polypeptide binding]; other site 203124003979 [2Fe-2S] cluster binding site [ion binding]; other site 203124003980 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 203124003981 tocopherol cyclase; Region: PLN02818 203124003982 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 203124003983 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 203124003984 Uncharacterized conserved protein [Function unknown]; Region: COG1432 203124003985 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 203124003986 putative metal binding site [ion binding]; other site 203124003987 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 203124003988 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 203124003989 active site 203124003990 HIGH motif; other site 203124003991 KMSKS motif; other site 203124003992 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 203124003993 tRNA binding surface [nucleotide binding]; other site 203124003994 anticodon binding site; other site 203124003995 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 203124003996 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 203124003997 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 203124003998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124003999 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 203124004000 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 203124004001 Beta-lactamase; Region: Beta-lactamase; cl01009 203124004002 PBP4 family; Region: PBP4; TIGR00666 203124004003 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 203124004004 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 203124004005 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 203124004006 dimer interface [polypeptide binding]; other site 203124004007 active site 203124004008 CoA binding pocket [chemical binding]; other site 203124004009 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 203124004010 putative acyl-acceptor binding pocket; other site 203124004011 Protein of unknown function (DUF2288); Region: DUF2288; cl02399 203124004012 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 203124004013 putative active site [active] 203124004014 Putative serine esterase (DUF676); Region: DUF676; pfam05057 203124004015 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124004016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124004017 binding surface 203124004018 TPR motif; other site 203124004019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124004020 binding surface 203124004021 TPR motif; other site 203124004022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124004023 binding surface 203124004024 TPR motif; other site 203124004025 geranylgeranyl reductase; Region: ChlP; TIGR02028 203124004026 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124004027 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 203124004028 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 203124004029 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 203124004030 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 203124004031 putative ligand binding site [chemical binding]; other site 203124004032 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 203124004033 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 203124004034 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 203124004035 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 203124004036 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 203124004037 E3 interaction surface; other site 203124004038 lipoyl attachment site [posttranslational modification]; other site 203124004039 e3 binding domain; Region: E3_binding; pfam02817 203124004040 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 203124004041 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 203124004042 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 203124004043 putative NAD(P) binding site [chemical binding]; other site 203124004044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124004045 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 203124004046 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 203124004047 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004048 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004049 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 203124004050 active site 203124004051 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004052 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004053 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004054 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004055 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004056 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004057 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004058 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004059 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004060 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004061 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004062 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004063 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004064 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5549 203124004065 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 203124004066 active site 203124004067 glycogen branching enzyme; Provisional; Region: PRK05402 203124004068 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 203124004069 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 203124004070 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 203124004071 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 203124004072 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 203124004073 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 203124004074 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 203124004075 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 203124004076 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124004077 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 203124004078 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124004079 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 203124004080 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 203124004081 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 203124004082 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 203124004083 PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130 203124004084 PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130 203124004085 PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130 203124004086 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 203124004087 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 203124004088 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 203124004089 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124004090 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 203124004091 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 203124004092 metal binding site [ion binding]; metal-binding site 203124004093 dimer interface [polypeptide binding]; other site 203124004094 phosphoribulokinase; Provisional; Region: PRK07429 203124004095 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 203124004096 Active site [active] 203124004097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124004098 S-adenosylmethionine binding site [chemical binding]; other site 203124004099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124004100 S-adenosylmethionine binding site [chemical binding]; other site 203124004101 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 203124004102 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 203124004103 RNA binding surface [nucleotide binding]; other site 203124004104 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 203124004105 active site 203124004106 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 203124004107 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 203124004108 putative valine binding site [chemical binding]; other site 203124004109 dimer interface [polypeptide binding]; other site 203124004110 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 203124004111 Integrase core domain; Region: rve; cl01316 203124004112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124004113 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 203124004114 putative active site [active] 203124004115 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 203124004116 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 203124004117 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 203124004118 Substrate binding site [chemical binding]; other site 203124004119 Cupin domain; Region: Cupin_2; cl09118 203124004120 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 203124004121 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 203124004122 Rrf2 family protein; Region: rrf2_super; TIGR00738 203124004123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 203124004124 CobD/Cbib protein; Region: CobD_Cbib; cl00561 203124004125 MoxR-like ATPases [General function prediction only]; Region: COG0714 203124004126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124004127 Walker A motif; other site 203124004128 ATP binding site [chemical binding]; other site 203124004129 Walker B motif; other site 203124004130 arginine finger; other site 203124004131 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 203124004132 RNA/DNA binding site [nucleotide binding]; other site 203124004133 RRM dimerization site [polypeptide binding]; other site 203124004134 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 203124004135 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 203124004136 active site 203124004137 Riboflavin kinase; Region: Flavokinase; pfam01687 203124004138 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 203124004139 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 203124004140 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 203124004141 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 203124004142 ligand binding site [chemical binding]; other site 203124004143 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 203124004144 putative active site [active] 203124004145 catalytic site [active] 203124004146 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 203124004147 putative active site [active] 203124004148 catalytic site [active] 203124004149 Protein of unknown function, DUF655; Region: DUF655; cl00648 203124004150 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 203124004151 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 203124004152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 203124004153 catalytic residue [active] 203124004154 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 203124004155 HflK protein; Region: hflK; TIGR01933 203124004156 Beta-propeller repeat; Region: SBBP; pfam06739 203124004157 Beta-propeller repeat; Region: SBBP; pfam06739 203124004158 Beta-propeller repeat; Region: SBBP; pfam06739 203124004159 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 203124004160 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 203124004161 Ligand Binding Site [chemical binding]; other site 203124004162 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 203124004163 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 203124004164 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 203124004165 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 203124004166 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 203124004167 23S rRNA binding site [nucleotide binding]; other site 203124004168 L21 binding site [polypeptide binding]; other site 203124004169 L13 binding site [polypeptide binding]; other site 203124004170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124004171 binding surface 203124004172 TPR motif; other site 203124004173 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124004174 active site 203124004175 substrate binding sites [chemical binding]; other site 203124004176 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 203124004177 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124004178 putative methanogenesis marker 16 metalloprotein; Region: methan_mark_16; TIGR03287 203124004179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 203124004180 PHP domain; Region: PHP; pfam02811 203124004181 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 203124004182 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 203124004183 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 203124004184 replicative DNA helicase; Validated; Region: PRK07773 203124004185 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 203124004186 replicative DNA helicase; Validated; Region: PRK07773 203124004187 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 203124004188 thioester formation/cholesterol transfer; other site 203124004189 protein-splicing catalytic site; other site 203124004190 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl09966 203124004191 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 203124004192 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 203124004193 thioester formation/cholesterol transfer; other site 203124004194 protein-splicing catalytic site; other site 203124004195 Integrin, beta chain; Region: Integrin_beta; pfam00362 203124004196 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 203124004197 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004198 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004199 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004200 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004201 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004202 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004203 Uncharacterized conserved protein [Function unknown]; Region: COG1572 203124004204 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004205 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004206 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004207 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004208 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004209 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004210 quinolinate synthetase A; Region: PLN02673 203124004211 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004212 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004213 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004214 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 203124004215 Isoamylase N-terminus domain. Isoamylase (aka glycogen 6-glucanohydrolase) is one of the starch-debranching enzymes that catalyzes the hydrolysis of alpha-1,6-glucosidic linkages specific in alpha-glucans such as amylopectin or glycogen. Isoamylase...; Region: Isoamylase_N_term; cd02852 203124004216 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 203124004217 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 203124004218 DNA gyrase subunit A; Validated; Region: PRK05560 203124004219 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 203124004220 CAP-like domain; other site 203124004221 Active site [active] 203124004222 primary dimer interface [polypeptide binding]; other site 203124004223 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 203124004224 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 203124004225 Response regulator receiver domain; Region: Response_reg; pfam00072 203124004226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124004227 active site 203124004228 phosphorylation site [posttranslational modification] 203124004229 intermolecular recognition site; other site 203124004230 dimerization interface [polypeptide binding]; other site 203124004231 K-Cl cotransporter; Region: 2a30; TIGR00930 203124004232 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 203124004233 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124004234 GTP/Mg2+ binding site [chemical binding]; other site 203124004235 G5 box; other site 203124004236 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 203124004237 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 203124004238 G1 box; other site 203124004239 G1 box; other site 203124004240 GTP/Mg2+ binding site [chemical binding]; other site 203124004241 Switch I region; other site 203124004242 Switch I region; other site 203124004243 G2 box; other site 203124004244 G2 box; other site 203124004245 Switch II region; other site 203124004246 G3 box; other site 203124004247 G3 box; other site 203124004248 Switch II region; other site 203124004249 G4 box; other site 203124004250 G5 box; other site 203124004251 Domain of unknown function (DUF697); Region: DUF697; cl12064 203124004252 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 203124004253 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl09966 203124004254 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 203124004255 generic binding surface II; other site 203124004256 generic binding surface I; other site 203124004257 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004258 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004259 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004260 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004261 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004262 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004263 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004264 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124004265 Calx-beta domain; Region: Calx-beta; cl02522 203124004266 Calx-beta domain; Region: Calx-beta; cl02522 203124004267 Calx-beta domain; Region: Calx-beta; cl02522 203124004268 Calx-beta domain; Region: Calx-beta; cl02522 203124004269 Calx-beta domain; Region: Calx-beta; cl02522 203124004270 Calx-beta domain; Region: Calx-beta; cl02522 203124004271 Peptidase family M48; Region: Peptidase_M48; cl12018 203124004272 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 203124004273 Probable transposase; Region: OrfB_IS605; pfam01385 203124004274 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 203124004275 light-harvesting-like protein 3; Provisional; Region: PLN00014 203124004276 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 203124004277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 203124004278 gamma-glutamyl kinase; Provisional; Region: PRK05429 203124004279 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 203124004280 nucleotide binding site [chemical binding]; other site 203124004281 homotetrameric interface [polypeptide binding]; other site 203124004282 putative phosphate binding site [ion binding]; other site 203124004283 putative allosteric binding site; other site 203124004284 PUA domain; Region: PUA; cl00607 203124004285 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 203124004286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124004287 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 203124004288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 203124004289 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 203124004290 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_subfamily; cd01464 203124004291 metal ion-dependent adhesion site (MIDAS); other site 203124004292 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 203124004293 active site 203124004294 ATP binding site [chemical binding]; other site 203124004295 substrate binding site [chemical binding]; other site 203124004296 activation loop (A-loop); other site 203124004297 GUN4-like; Region: GUN4; pfam05419 203124004298 Flavin Reductases; Region: FlaRed; cl00801 203124004299 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 203124004300 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 203124004301 Peptidase family S48; Region: Peptidase_S48; cl11616 203124004302 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 203124004303 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 203124004304 ligand-binding site [chemical binding]; other site 203124004305 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 203124004306 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 203124004307 polysaccharide export protein Wza; Provisional; Region: PRK15078 203124004308 SLBB domain; Region: SLBB; pfam10531 203124004309 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 203124004310 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 203124004311 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124004312 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 203124004313 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 203124004314 NAD(P) binding site [chemical binding]; other site 203124004315 catalytic residues [active] 203124004316 acetolactate synthase; Reviewed; Region: PRK08322 203124004317 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 203124004318 PYR/PP interface [polypeptide binding]; other site 203124004319 dimer interface [polypeptide binding]; other site 203124004320 TPP binding site [chemical binding]; other site 203124004321 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 203124004322 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 203124004323 TPP-binding site [chemical binding]; other site 203124004324 dimer interface [polypeptide binding]; other site 203124004325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124004326 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 203124004327 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124004328 Walker A/P-loop; other site 203124004329 ATP binding site [chemical binding]; other site 203124004330 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124004331 ABC transporter signature motif; other site 203124004332 Walker B; other site 203124004333 D-loop; other site 203124004334 H-loop/switch region; other site 203124004335 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 203124004336 Active Sites [active] 203124004337 DGQHR domain; Region: DGQHR; cl14002 203124004338 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 203124004339 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 203124004340 substrate binding pocket [chemical binding]; other site 203124004341 aspartate-rich region 1; other site 203124004342 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 203124004343 substrate binding site [chemical binding]; other site 203124004344 ATP binding site [chemical binding]; other site 203124004345 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 203124004346 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124004347 ATP binding site [chemical binding]; other site 203124004348 putative Mg++ binding site [ion binding]; other site 203124004349 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203124004350 nucleotide binding region [chemical binding]; other site 203124004351 ATP-binding site [chemical binding]; other site 203124004352 alpha-glucosidase; Provisional; Region: PRK10137 203124004353 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 203124004354 Protein of unknown function (DUF990); Region: DUF990; cl01496 203124004355 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 203124004356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124004357 binding surface 203124004358 TPR motif; other site 203124004359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124004360 binding surface 203124004361 TPR motif; other site 203124004362 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124004363 binding surface 203124004364 TPR motif; other site 203124004365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124004366 binding surface 203124004367 TPR motif; other site 203124004368 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124004369 binding surface 203124004370 TPR motif; other site 203124004371 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 203124004372 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 203124004373 Active site [active] 203124004374 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 203124004375 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 203124004376 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 203124004377 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 203124004378 metal binding site 2 [ion binding]; metal-binding site 203124004379 putative DNA binding helix; other site 203124004380 metal binding site 1 [ion binding]; metal-binding site 203124004381 dimer interface [polypeptide binding]; other site 203124004382 structural Zn2+ binding site [ion binding]; other site 203124004383 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 203124004384 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 203124004385 putative active site [active] 203124004386 catalytic triad [active] 203124004387 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 203124004388 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 203124004389 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 203124004390 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 203124004391 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 203124004392 DNA binding residues [nucleotide binding] 203124004393 lipoyl synthase; Provisional; Region: PRK05481 203124004394 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 203124004395 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 203124004396 metal binding site 2 [ion binding]; metal-binding site 203124004397 putative DNA binding helix; other site 203124004398 metal binding site 1 [ion binding]; metal-binding site 203124004399 dimer interface [polypeptide binding]; other site 203124004400 structural Zn2+ binding site [ion binding]; other site 203124004401 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 203124004402 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 203124004403 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 203124004404 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 203124004405 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 203124004406 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 203124004407 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 203124004408 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 203124004409 proposed catalytic triad [active] 203124004410 active site nucleophile [active] 203124004411 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 203124004412 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 203124004413 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 203124004414 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 203124004415 light-harvesting-like protein 3; Provisional; Region: PLN00014 203124004416 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 203124004417 dimerization interface [polypeptide binding]; other site 203124004418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 203124004419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 203124004420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 203124004421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124004422 binding surface 203124004423 TPR motif; other site 203124004424 MEKHLA domain; Region: MEKHLA; pfam08670 203124004425 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 203124004426 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 203124004427 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 203124004428 Phosphopantetheine attachment site; Region: PP-binding; cl09936 203124004429 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 203124004430 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 203124004431 substrate-cofactor binding pocket; other site 203124004432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124004433 catalytic residue [active] 203124004434 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 203124004435 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124004436 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004437 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004438 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004439 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124004440 haemagglutination activity domain; Region: Haemagg_act; cl05436 203124004441 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 203124004442 CHAT domain; Region: CHAT; cl02083 203124004443 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 203124004444 metal ion-dependent adhesion site (MIDAS); other site 203124004445 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 203124004446 flagellar assembly protein H; Validated; Region: fliH; PRK05687 203124004447 NAD synthetase; Provisional; Region: PRK13981 203124004448 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 203124004449 multimer interface [polypeptide binding]; other site 203124004450 active site 203124004451 catalytic triad [active] 203124004452 protein interface 1 [polypeptide binding]; other site 203124004453 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 203124004454 homodimer interface [polypeptide binding]; other site 203124004455 NAD binding pocket [chemical binding]; other site 203124004456 ATP binding pocket [chemical binding]; other site 203124004457 Mg binding site [ion binding]; other site 203124004458 active-site loop [active] 203124004459 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 203124004460 CHASE2 domain; Region: CHASE2; cl01732 203124004461 cyclase homology domain; Region: CHD; cd07302 203124004462 nucleotidyl binding site; other site 203124004463 metal binding site [ion binding]; metal-binding site 203124004464 dimer interface [polypeptide binding]; other site 203124004465 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 203124004466 FeS/SAM binding site; other site 203124004467 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 203124004468 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 203124004469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124004470 S-adenosylmethionine binding site [chemical binding]; other site 203124004471 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 203124004472 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 203124004473 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 203124004474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 203124004475 motif II; other site 203124004476 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 203124004477 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 203124004478 substrate binding pocket [chemical binding]; other site 203124004479 membrane-bound complex binding site; other site 203124004480 hinge residues; other site 203124004481 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 203124004482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 203124004483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 203124004484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124004485 putative PBP binding loops; other site 203124004486 dimer interface [polypeptide binding]; other site 203124004487 ABC-ATPase subunit interface; other site 203124004488 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 203124004489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124004490 dimer interface [polypeptide binding]; other site 203124004491 conserved gate region; other site 203124004492 putative PBP binding loops; other site 203124004493 ABC-ATPase subunit interface; other site 203124004494 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 203124004495 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 203124004496 Walker A/P-loop; other site 203124004497 ATP binding site [chemical binding]; other site 203124004498 Q-loop/lid; other site 203124004499 ABC transporter signature motif; other site 203124004500 Walker B; other site 203124004501 D-loop; other site 203124004502 H-loop/switch region; other site 203124004503 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 203124004504 DNA binding residues [nucleotide binding] 203124004505 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 203124004506 catalytic residues [active] 203124004507 catalytic nucleophile [active] 203124004508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 203124004509 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 203124004510 Probable transposase; Region: OrfB_IS605; pfam01385 203124004511 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 203124004512 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 203124004513 active site 203124004514 DNA binding site [nucleotide binding] 203124004515 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 203124004516 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124004517 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 203124004518 quinone interaction residues [chemical binding]; other site 203124004519 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 203124004520 active site 203124004521 catalytic residues [active] 203124004522 FMN binding site [chemical binding]; other site 203124004523 substrate binding site [chemical binding]; other site 203124004524 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 203124004525 putative active site [active] 203124004526 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 203124004527 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 203124004528 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 203124004529 putative dimerization interface [polypeptide binding]; other site 203124004530 NnrU protein; Region: NnrU; cl01697 203124004531 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 203124004532 catalytic residues [active] 203124004533 putative 5S ribosomal RNA; very low similarity 203124004534 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124004535 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 203124004536 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 203124004537 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 203124004538 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 203124004539 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 203124004540 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 203124004541 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 203124004542 ligand binding site [chemical binding]; other site 203124004543 flexible hinge region; other site 203124004544 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 203124004545 putative switch regulator; other site 203124004546 non-specific DNA interactions [nucleotide binding]; other site 203124004547 DNA binding site [nucleotide binding] 203124004548 sequence specific DNA binding site [nucleotide binding]; other site 203124004549 putative cAMP binding site [chemical binding]; other site 203124004550 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 203124004551 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 203124004552 NAD binding site [chemical binding]; other site 203124004553 homotetramer interface [polypeptide binding]; other site 203124004554 homodimer interface [polypeptide binding]; other site 203124004555 substrate binding site [chemical binding]; other site 203124004556 active site 203124004557 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124004558 putative active site [active] 203124004559 putative NTP binding site [chemical binding]; other site 203124004560 putative nucleic acid binding site [nucleotide binding]; other site 203124004561 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 203124004562 putative active site pocket [active] 203124004563 4-fold oligomerization interface [polypeptide binding]; other site 203124004564 metal binding residues [ion binding]; metal-binding site 203124004565 3-fold/trimer interface [polypeptide binding]; other site 203124004566 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124004567 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 203124004568 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 203124004569 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 203124004570 Protein kinase; unclassified specificity; Region: STYKc; smart00221 203124004571 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124004572 active site 203124004573 ATP binding site [chemical binding]; other site 203124004574 substrate binding site [chemical binding]; other site 203124004575 activation loop (A-loop); other site 203124004576 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124004577 structural tetrad; other site 203124004578 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124004579 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 203124004580 putative active site [active] 203124004581 catalytic triad [active] 203124004582 von Willebrand factor type D domain; Region: VWD; cl02516 203124004583 Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium; plays a role in cell...; Region: CA; cl02468 203124004584 Ca2+ binding site [ion binding]; other site 203124004585 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 203124004586 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 203124004587 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 203124004588 Protein of unknown function (DUF785); Region: DUF785; cl01682 203124004589 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 203124004590 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 203124004591 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 203124004592 substrate binding pocket [chemical binding]; other site 203124004593 substrate-Mg2+ binding site; other site 203124004594 aspartate-rich region 1; other site 203124004595 aspartate-rich region 2; other site 203124004596 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051 203124004597 Ca2+ binding site [ion binding]; other site 203124004598 Staphylococcal nuclease homologues; Region: SNc; smart00318 203124004599 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 203124004600 Catalytic site; other site 203124004601 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 203124004602 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 203124004603 Sodium:solute symporter family; Region: SSF; cl00456 203124004604 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124004605 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 203124004606 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124004607 active site 203124004608 ATP binding site [chemical binding]; other site 203124004609 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124004610 substrate binding site [chemical binding]; other site 203124004611 activation loop (A-loop); other site 203124004612 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 203124004613 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124004614 phosphoethanolamine N-methyltransferase; Provisional; Region: PTZ00098 203124004615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124004616 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 203124004617 FAD binding domain; Region: FAD_binding_4; pfam01565 203124004618 CHRD domain; Region: CHRD; cl06473 203124004619 CHRD domain; Region: CHRD; cl06473 203124004620 CHRD domain; Region: CHRD; cl06473 203124004621 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124004622 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 203124004623 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 203124004624 Cysteine-rich domain; Region: CCG; pfam02754 203124004625 Cysteine-rich domain; Region: CCG; pfam02754 203124004626 KWG Leptospira; Region: KWG; pfam07656 203124004627 KWG Leptospira; Region: KWG; pfam07656 203124004628 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 203124004629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124004630 MoxR-like ATPases [General function prediction only]; Region: COG0714 203124004631 Walker B motif; other site 203124004632 arginine finger; other site 203124004633 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 203124004634 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124004635 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124004636 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 203124004637 tRNA synthetase B5 domain; Region: B5; cl08394 203124004638 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 203124004639 putative tRNA-binding site [nucleotide binding]; other site 203124004640 B3/4 domain; Region: B3_4; cl11458 203124004641 tRNA synthetase B5 domain; Region: B5; cl08394 203124004642 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 203124004643 dimer interface [polypeptide binding]; other site 203124004644 motif 1; other site 203124004645 motif 3; other site 203124004646 motif 2; other site 203124004647 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 203124004648 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124004649 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124004650 active site 203124004651 ATP binding site [chemical binding]; other site 203124004652 substrate binding site [chemical binding]; other site 203124004653 activation loop (A-loop); other site 203124004654 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124004655 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 203124004656 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 203124004657 tellurite resistance protein terB; Region: terB; cd07176 203124004658 putative metal binding site [ion binding]; other site 203124004659 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124004660 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 203124004661 putative ADP-binding pocket [chemical binding]; other site 203124004662 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124004663 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124004664 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 203124004665 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 203124004666 Cupin domain; Region: Cupin_2; cl09118 203124004667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124004668 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 203124004669 Walker A motif; other site 203124004670 ATP binding site [chemical binding]; other site 203124004671 Walker B motif; other site 203124004672 arginine finger; other site 203124004673 CHAT domain; Region: CHAT; cl02083 203124004674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 203124004675 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 203124004676 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 203124004677 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124004678 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 203124004679 Initiation factor 2 subunit family; Region: IF-2B; pfam01008 203124004680 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 203124004681 Thymidylate synthase complementing protein; Region: Thy1; cl03630 203124004682 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 203124004683 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl09966 203124004684 Thymidylate synthase complementing protein; Region: Thy1; cl03630 203124004685 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 203124004686 trimer interface [polypeptide binding]; other site 203124004687 active site 203124004688 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 203124004689 catalytic motif [active] 203124004690 Zn binding site [ion binding]; other site 203124004691 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 203124004692 DGQHR domain; Region: DGQHR; cl14002 203124004693 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124004694 Walker A motif; other site 203124004695 ATP binding site [chemical binding]; other site 203124004696 Walker B motif; other site 203124004697 ribonuclease PH; Reviewed; Region: rph; PRK00173 203124004698 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 203124004699 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 203124004700 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 203124004701 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 203124004702 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 203124004703 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 203124004704 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 203124004705 N-acetyl-D-glucosamine binding site [chemical binding]; other site 203124004706 catalytic residue [active] 203124004707 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 203124004708 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124004709 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124004710 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124004711 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124004712 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124004713 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 203124004714 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 203124004715 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 203124004716 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124004717 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 203124004718 Domain of unknown function DUF21; Region: DUF21; pfam01595 203124004719 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 203124004720 Transporter associated domain; Region: CorC_HlyC; pfam03471 203124004721 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 203124004722 putative transporter; Provisional; Region: PRK11462 203124004723 Protein kinase domain; Region: Pkinase; pfam00069 203124004724 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124004725 active site 203124004726 ATP binding site [chemical binding]; other site 203124004727 substrate binding site [chemical binding]; other site 203124004728 activation loop (A-loop); other site 203124004729 Predicted ATPase [General function prediction only]; Region: COG3899 203124004730 Predicted ATPase [General function prediction only]; Region: COG3899 203124004731 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124004732 GAF domain; Region: GAF; cl00853 203124004733 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 203124004734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124004735 ATP binding site [chemical binding]; other site 203124004736 Mg2+ binding site [ion binding]; other site 203124004737 G-X-G motif; other site 203124004738 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 203124004739 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 203124004740 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 203124004741 Phosphopantetheine attachment site; Region: PP-binding; cl09936 203124004742 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124004743 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 203124004744 sulfotransferase; Region: PLN02164 203124004745 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124004746 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 203124004747 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 203124004748 active site 203124004749 TDP-binding site; other site 203124004750 acceptor substrate-binding pocket; other site 203124004751 homodimer interface [polypeptide binding]; other site 203124004752 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124004753 active site 203124004754 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 203124004755 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124004756 FO synthase subunit 2; Reviewed; Region: PRK07360 203124004757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 203124004758 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 203124004759 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 203124004760 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 203124004761 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124004762 RF-1 domain; Region: RF-1; cl02875 203124004763 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 203124004764 RF-1 domain; Region: RF-1; cl02875 203124004765 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cl00473 203124004766 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 203124004767 Protein of unknown function (DUF790); Region: DUF790; pfam05626 203124004768 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 203124004769 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 203124004770 Domain of unknown function DUF28; Region: DUF28; cl00361 203124004771 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 203124004772 catalytic core [active] 203124004773 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 203124004774 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124004775 Cupin domain; Region: Cupin_2; cl09118 203124004776 CHAT domain; Region: CHAT; cl02083 203124004777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124004778 Walker A motif; other site 203124004779 ATP binding site [chemical binding]; other site 203124004780 Walker B motif; other site 203124004781 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124004782 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 203124004783 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 203124004784 active site 203124004785 catalytic tetrad [active] 203124004786 Cytochrome c; Region: Cytochrom_C; cl11414 203124004787 Cytochrome B6-F complex subunit 5; Region: PetG; cl03637 203124004788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124004789 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 203124004790 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 203124004791 putative active site [active] 203124004792 oxyanion strand; other site 203124004793 catalytic triad [active] 203124004794 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 203124004795 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 203124004796 dimerization interface [polypeptide binding]; other site 203124004797 active site 203124004798 metal binding site [ion binding]; metal-binding site 203124004799 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 203124004800 dsRNA binding site [nucleotide binding]; other site 203124004801 Nop53 (60S ribosomal biogenesis); Region: Nop53; pfam07767 203124004802 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 203124004803 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 203124004804 putative active site [active] 203124004805 putative NTP binding site [chemical binding]; other site 203124004806 putative nucleic acid binding site [nucleotide binding]; other site 203124004807 glycogen synthase; Provisional; Region: glgA; PRK00654 203124004808 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 203124004809 ADP-binding pocket [chemical binding]; other site 203124004810 homodimer interface [polypeptide binding]; other site 203124004811 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 203124004812 Uncharacterized conserved protein [Function unknown]; Region: COG4997 203124004813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124004814 S-adenosylmethionine binding site [chemical binding]; other site 203124004815 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 203124004816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124004817 Walker A/P-loop; other site 203124004818 ATP binding site [chemical binding]; other site 203124004819 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of methylmalonyl-; Region: MM_CoA_mutase; cl00817 203124004820 Orbivirus VP3 (T2) protein; Region: Orbi_VP3; pfam01700 203124004821 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 203124004822 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 203124004823 active site 203124004824 catalytic tetrad [active] 203124004825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124004826 S-adenosylmethionine binding site [chemical binding]; other site 203124004827 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 203124004828 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 203124004829 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124004830 CHAT domain; Region: CHAT; cl02083 203124004831 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 203124004832 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124004833 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 203124004834 metal ion-dependent adhesion site (MIDAS); other site 203124004835 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 203124004836 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 203124004837 phosphate binding site [ion binding]; other site 203124004838 putative substrate binding pocket [chemical binding]; other site 203124004839 dimer interface [polypeptide binding]; other site 203124004840 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 203124004841 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 203124004842 Walker A/P-loop; other site 203124004843 ATP binding site [chemical binding]; other site 203124004844 Q-loop/lid; other site 203124004845 ABC transporter signature motif; other site 203124004846 Walker B; other site 203124004847 D-loop; other site 203124004848 H-loop/switch region; other site 203124004849 mce related protein; Region: MCE; cl03606 203124004850 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 203124004851 mce related protein; Region: MCE; cl03606 203124004852 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 203124004853 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124004854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124004855 binding surface 203124004856 TPR motif; other site 203124004857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124004858 TPR motif; other site 203124004859 binding surface 203124004860 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 203124004861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124004862 binding surface 203124004863 TPR motif; other site 203124004864 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 203124004865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124004866 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 203124004867 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 203124004868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124004869 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124004870 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 203124004871 tocopherol O-methyltransferase; Region: PLN02244 203124004872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124004873 S-adenosylmethionine binding site [chemical binding]; other site 203124004874 dihydroorotase; Provisional; Region: PRK07575 203124004875 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 203124004876 active site 203124004877 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 203124004878 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 203124004879 Catalytic site [active] 203124004880 dihydroorotase; Validated; Region: pyrC; PRK09357 203124004881 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 203124004882 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 203124004883 active site 203124004884 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 203124004885 catalytic core [active] 203124004886 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 203124004887 catalytic core [active] 203124004888 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 203124004889 EamA-like transporter family; Region: EamA; cl01037 203124004890 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 203124004891 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 203124004892 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 203124004893 shikimate binding site; other site 203124004894 NAD(P) binding site [chemical binding]; other site 203124004895 YGGT family; Region: YGGT; cl00508 203124004896 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 203124004897 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 203124004898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124004899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124004900 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 203124004901 active site 203124004902 catalytic triad [active] 203124004903 ATP synthase; Region: ATP-synt; cl00365 203124004904 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 203124004905 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 203124004906 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 203124004907 beta subunit interaction interface [polypeptide binding]; other site 203124004908 Walker A motif; other site 203124004909 ATP binding site [chemical binding]; other site 203124004910 Walker B motif; other site 203124004911 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 203124004912 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 203124004913 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 203124004914 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 203124004915 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 203124004916 ATP synthase subunit C; Region: ATP-synt_C; cl00466 203124004917 ATP synthase A chain; Region: ATP-synt_A; cl00413 203124004918 ATP synthase I chain; Region: ATP_synt_I; cl09170 203124004919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124004920 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 203124004921 S-adenosylmethionine binding site [chemical binding]; other site 203124004922 Protein of unknown function DUF262; Region: DUF262; cl14890 203124004923 Phycobilisome protein; Region: Phycobilisome; cl08227 203124004924 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 203124004925 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 203124004926 phycobillisome linker protein; Region: apcE; CHL00091 203124004927 Phycobilisome protein; Region: Phycobilisome; cl08227 203124004928 Phycobilisome protein; Region: Phycobilisome; cl08227 203124004929 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 203124004930 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 203124004931 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 203124004932 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 203124004933 metal ion-dependent adhesion site (MIDAS); other site 203124004934 Ycf46; Provisional; Region: ycf46; CHL00195 203124004935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124004936 Walker A motif; other site 203124004937 ATP binding site [chemical binding]; other site 203124004938 Walker B motif; other site 203124004939 arginine finger; other site 203124004940 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 203124004941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124004942 M28, and M42; Region: Zinc_peptidase_like; cl14876 203124004943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 203124004944 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 203124004945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124004946 dimer interface [polypeptide binding]; other site 203124004947 phosphorylation site [posttranslational modification] 203124004948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124004949 ATP binding site [chemical binding]; other site 203124004950 Mg2+ binding site [ion binding]; other site 203124004951 G-X-G motif; other site 203124004952 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 203124004953 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 203124004954 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124004955 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 203124004956 ThiS interaction site; other site 203124004957 putative active site [active] 203124004958 tetramer interface [polypeptide binding]; other site 203124004959 conserved hypothetical protein; Region: TIGR03492 203124004960 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 203124004961 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 203124004962 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 203124004963 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 203124004964 Electron transfer DM13; Region: DM13; cl02735 203124004965 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124004966 structural tetrad; other site 203124004967 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 203124004968 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124004969 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124004970 hypothetical protein; Validated; Region: PRK08116 203124004971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124004972 Walker A motif; other site 203124004973 ATP binding site [chemical binding]; other site 203124004974 Walker B motif; other site 203124004975 CHAT domain; Region: CHAT; cl02083 203124004976 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124004977 FOG: CBS domain [General function prediction only]; Region: COG0517 203124004978 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 203124004979 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 203124004980 dimer interface [polypeptide binding]; other site 203124004981 [2Fe-2S] cluster binding site [ion binding]; other site 203124004982 hydrolase; Region: PLN02578 203124004983 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124004984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 203124004985 chromosome segregation protein; Provisional; Region: PRK03918 203124004986 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 203124004987 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318 203124004988 putative dimer interface [polypeptide binding]; other site 203124004989 putative anticodon binding site; other site 203124004990 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 203124004991 homodimer interface [polypeptide binding]; other site 203124004992 motif 1; other site 203124004993 motif 2; other site 203124004994 active site 203124004995 motif 3; other site 203124004996 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 203124004997 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 203124004998 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 203124004999 active site 203124005000 metal binding site [ion binding]; metal-binding site 203124005001 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 203124005002 Peptidase family M48; Region: Peptidase_M48; cl12018 203124005003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124005004 S-adenosylmethionine binding site [chemical binding]; other site 203124005005 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 203124005006 2-isopropylmalate synthase; Validated; Region: PRK00915 203124005007 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 203124005008 active site 203124005009 catalytic residues [active] 203124005010 metal binding site [ion binding]; metal-binding site 203124005011 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 203124005012 TIGR03442 family protein; Region: TIGR03442 203124005013 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 203124005014 putative active site [active] 203124005015 putative dimer interface [polypeptide binding]; other site 203124005016 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 203124005017 intermolecular salt bridges; other site 203124005018 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 203124005019 intermolecular salt bridges; other site 203124005020 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 203124005021 Beta-lactamase; Region: Beta-lactamase; cl01009 203124005022 Integrase core domain; Region: rve; cl01316 203124005023 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 203124005024 substrate binding site [chemical binding]; other site 203124005025 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 203124005026 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 203124005027 inhibitor-cofactor binding pocket; inhibition site 203124005028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124005029 catalytic residue [active] 203124005030 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 203124005031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124005032 NAD(P) binding site [chemical binding]; other site 203124005033 active site 203124005034 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 203124005035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124005036 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 203124005037 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 203124005038 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 203124005039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124005040 NAD(P) binding site [chemical binding]; other site 203124005041 active site 203124005042 Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421 203124005043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124005044 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 203124005045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005046 binding surface 203124005047 TPR motif; other site 203124005048 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 203124005049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005050 TPR motif; other site 203124005051 binding surface 203124005052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005053 TPR motif; other site 203124005054 binding surface 203124005055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005056 binding surface 203124005057 TPR motif; other site 203124005058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005059 binding surface 203124005060 TPR motif; other site 203124005061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005062 binding surface 203124005063 TPR motif; other site 203124005064 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124005065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005066 binding surface 203124005067 TPR motif; other site 203124005068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005069 binding surface 203124005070 TPR motif; other site 203124005071 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism]; Region: COG4421 203124005072 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 203124005073 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 203124005074 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 203124005075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005076 binding surface 203124005077 TPR motif; other site 203124005078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005079 binding surface 203124005080 TPR motif; other site 203124005081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005082 binding surface 203124005083 TPR motif; other site 203124005084 Protein of unknown function (DUF616); Region: DUF616; pfam04765 203124005085 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 203124005086 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 203124005087 Probable Catalytic site [active] 203124005088 metal binding site [ion binding]; metal-binding site 203124005089 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124005090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124005091 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 203124005092 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 203124005093 Walker A/P-loop; other site 203124005094 ATP binding site [chemical binding]; other site 203124005095 Q-loop/lid; other site 203124005096 ABC transporter signature motif; other site 203124005097 Walker B; other site 203124005098 D-loop; other site 203124005099 H-loop/switch region; other site 203124005100 OstA-like protein; Region: OstA; cl00844 203124005101 Mechanosensitive ion channel; Region: MS_channel; pfam00924 203124005102 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 203124005103 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 203124005104 putative catalytic cysteine [active] 203124005105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124005106 S-adenosylmethionine binding site [chemical binding]; other site 203124005107 acyl-ACP reductase; Provisional; Region: PRK14982 203124005108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124005109 NAD(P) binding pocket [chemical binding]; other site 203124005110 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 203124005111 dinuclear metal binding motif [ion binding]; other site 203124005112 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 203124005113 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 203124005114 dimerization interface [polypeptide binding]; other site 203124005115 domain crossover interface; other site 203124005116 redox-dependent activation switch; other site 203124005117 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 203124005118 TspO/MBR family; Region: TspO_MBR; cl01379 203124005119 Sodium:solute symporter family; Region: SSF; cl00456 203124005120 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 203124005121 Archaeal ATPase; Region: Arch_ATPase; pfam01637 203124005122 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124005123 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 203124005124 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124005125 Integrase core domain; Region: rve; cl01316 203124005126 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124005127 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 203124005128 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 203124005129 Flagellin N-methylase; Region: FliB; cl00497 203124005130 Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139 203124005131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 203124005132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124005133 active site 203124005134 phosphorylation site [posttranslational modification] 203124005135 intermolecular recognition site; other site 203124005136 dimerization interface [polypeptide binding]; other site 203124005137 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 203124005138 DNA binding site [nucleotide binding] 203124005139 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 203124005140 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 203124005141 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 203124005142 Walker A/P-loop; other site 203124005143 ATP binding site [chemical binding]; other site 203124005144 Q-loop/lid; other site 203124005145 ABC transporter signature motif; other site 203124005146 Walker B; other site 203124005147 D-loop; other site 203124005148 H-loop/switch region; other site 203124005149 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 203124005150 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124005151 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 203124005152 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 203124005153 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 203124005154 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 203124005155 catalytic motif [active] 203124005156 Catalytic residue [active] 203124005157 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 203124005158 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 203124005159 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 203124005160 catalytic site [active] 203124005161 subunit interface [polypeptide binding]; other site 203124005162 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 203124005163 anti sigma factor interaction site; other site 203124005164 regulatory phosphorylation site [posttranslational modification]; other site 203124005165 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 203124005166 active site 203124005167 metal binding site [ion binding]; metal-binding site 203124005168 dimerization interface [polypeptide binding]; other site 203124005169 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 203124005170 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 203124005171 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 203124005172 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 203124005173 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 203124005174 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 203124005175 nucleotide binding pocket [chemical binding]; other site 203124005176 K-X-D-G motif; other site 203124005177 catalytic site [active] 203124005178 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 203124005179 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 203124005180 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 203124005181 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 203124005182 Dimer interface [polypeptide binding]; other site 203124005183 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124005184 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 203124005185 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 203124005186 RNA binding site [nucleotide binding]; other site 203124005187 active site 203124005188 Gas vesicle protein; Region: Gas_vesicle; cl02954 203124005189 Gas vesicle protein; Region: Gas_vesicle; cl02954 203124005190 Gas vesicle protein; Region: Gas_vesicle; cl02954 203124005191 Gas vesicle protein; Region: Gas_vesicle; cl02954 203124005192 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 203124005193 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 203124005194 P loop; other site 203124005195 Nucleotide binding site [chemical binding]; other site 203124005196 DTAP/Switch II; other site 203124005197 Switch I; other site 203124005198 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124005199 ATP binding site [chemical binding]; other site 203124005200 dimerization interface [polypeptide binding]; other site 203124005201 Metal binding site [ion binding]; metal-binding site 203124005202 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 203124005203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124005204 Walker A motif; other site 203124005205 ATP binding site [chemical binding]; other site 203124005206 Walker B motif; other site 203124005207 Gas vesicle protein; Region: Gas_vesicle; cl02954 203124005208 Gas vesicle protein K; Region: GvpK; pfam05121 203124005209 Gas vesicle protein; Region: Gas_vesicle; cl02954 203124005210 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 203124005211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124005212 Walker A motif; other site 203124005213 ATP binding site [chemical binding]; other site 203124005214 Walker B motif; other site 203124005215 Gas vesicle protein; Region: Gas_vesicle; cl02954 203124005216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124005217 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 203124005218 Walker A motif; other site 203124005219 ATP binding site [chemical binding]; other site 203124005220 Walker B motif; other site 203124005221 arginine finger; other site 203124005222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124005223 Walker A motif; other site 203124005224 ATP binding site [chemical binding]; other site 203124005225 Walker B motif; other site 203124005226 arginine finger; other site 203124005227 Gas vesicle protein G; Region: GvpG; pfam05120 203124005228 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 203124005229 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 203124005230 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 203124005231 SmpB-tmRNA interface; other site 203124005232 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 203124005233 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 203124005234 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 203124005235 putative binding surface; other site 203124005236 active site 203124005237 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124005238 active site 203124005239 ATP binding site [chemical binding]; other site 203124005240 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124005241 substrate binding site [chemical binding]; other site 203124005242 activation loop (A-loop); other site 203124005243 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124005244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005245 binding surface 203124005246 TPR motif; other site 203124005247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005248 binding surface 203124005249 TPR motif; other site 203124005250 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124005251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005252 binding surface 203124005253 TPR motif; other site 203124005254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005255 binding surface 203124005256 TPR motif; other site 203124005257 phosphodiesterase; Provisional; Region: PRK12704 203124005258 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 203124005259 MgtE intracellular N domain; Region: MgtE_N; cl15244 203124005260 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 203124005261 Divalent cation transporter; Region: MgtE; cl00786 203124005262 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 203124005263 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 203124005264 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 203124005265 Ligand Binding Site [chemical binding]; other site 203124005266 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 203124005267 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 203124005268 dimer interface [polypeptide binding]; other site 203124005269 anticodon binding site; other site 203124005270 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 203124005271 homodimer interface [polypeptide binding]; other site 203124005272 motif 1; other site 203124005273 active site 203124005274 motif 2; other site 203124005275 GAD domain; Region: GAD; pfam02938 203124005276 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 203124005277 motif 3; other site 203124005278 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 203124005279 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 203124005280 YcaO-like family; Region: YcaO; cl09146 203124005281 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 203124005282 Protein of unknown function (DUF433); Region: DUF433; cl01030 203124005283 XisI protein; Region: XisI; pfam08869 203124005284 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 203124005285 putative FMN binding site [chemical binding]; other site 203124005286 NADPH bind site [chemical binding]; other site 203124005287 Transposase IS200 like; Region: Y1_Tnp; cl00848 203124005288 Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476 203124005289 putative active site [active] 203124005290 putative catalytic triad [active] 203124005291 cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895 203124005292 Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476 203124005293 putative active site [active] 203124005294 putative catalytic triad [active] 203124005295 cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895 203124005296 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 203124005297 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 203124005298 dimer interface [polypeptide binding]; other site 203124005299 putative anticodon binding site; other site 203124005300 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 203124005301 motif 1; other site 203124005302 active site 203124005303 motif 2; other site 203124005304 motif 3; other site 203124005305 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 203124005306 metal ion-dependent adhesion site (MIDAS); other site 203124005307 acetyl-CoA synthetase; Provisional; Region: PRK00174 203124005308 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 203124005309 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 203124005310 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 203124005311 G1 box; other site 203124005312 GTP/Mg2+ binding site [chemical binding]; other site 203124005313 Switch I region; other site 203124005314 G2 box; other site 203124005315 Switch II region; other site 203124005316 G3 box; other site 203124005317 Domain of unknown function (DUF697); Region: DUF697; cl12064 203124005318 V-type ATP synthase subunit I; Validated; Region: PRK05771 203124005319 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 203124005320 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 203124005321 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 203124005322 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 203124005323 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 203124005324 Predicted GTPase [General function prediction only]; Region: COG3596 203124005325 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 203124005326 G1 box; other site 203124005327 GTP/Mg2+ binding site [chemical binding]; other site 203124005328 Switch I region; other site 203124005329 G2 box; other site 203124005330 Switch II region; other site 203124005331 G3 box; other site 203124005332 G4 box; other site 203124005333 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124005334 UvrD/REP helicase; Region: UvrD-helicase; cl14126 203124005335 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 203124005336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005337 binding surface 203124005338 TPR motif; other site 203124005339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005340 binding surface 203124005341 TPR motif; other site 203124005342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005343 binding surface 203124005344 TPR motif; other site 203124005345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005346 binding surface 203124005347 TPR motif; other site 203124005348 lipoprotein NlpI; Provisional; Region: PRK11189 203124005349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005350 binding surface 203124005351 TPR motif; other site 203124005352 SGT1, suppressor of G2 allele of SKP1; Provisional; Region: PLN03088 203124005353 Survival protein SurE; Region: SurE; cl00448 203124005354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005355 binding surface 203124005356 TPR motif; other site 203124005357 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 203124005358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124005359 S-adenosylmethionine binding site [chemical binding]; other site 203124005360 Domain of unknown function DUF20; Region: UPF0118; cl00465 203124005361 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 203124005362 Domain of unknown function DUF39; Region: DUF39; cl14897 203124005363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005364 TPR motif; other site 203124005365 binding surface 203124005366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005367 binding surface 203124005368 TPR motif; other site 203124005369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124005370 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 203124005371 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 203124005372 active site 203124005373 substrate binding site [chemical binding]; other site 203124005374 FMN binding site [chemical binding]; other site 203124005375 putative catalytic residues [active] 203124005376 TM2 domain; Region: TM2; cl00984 203124005377 Peptidase family M48; Region: Peptidase_M48; cl12018 203124005378 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 203124005379 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 203124005380 active site 203124005381 homodimer interface [polypeptide binding]; other site 203124005382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124005383 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 203124005384 active site 203124005385 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 203124005386 putative active site [active] 203124005387 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 203124005388 C-terminal peptidase (prc); Region: prc; TIGR00225 203124005389 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 203124005390 protein binding site [polypeptide binding]; other site 203124005391 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 203124005392 Catalytic dyad [active] 203124005393 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 203124005394 MPT binding site; other site 203124005395 trimer interface [polypeptide binding]; other site 203124005396 Psb28 protein; Region: Psb28; cl04326 203124005397 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 203124005398 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124005399 Walker A/P-loop; other site 203124005400 ATP binding site [chemical binding]; other site 203124005401 Q-loop/lid; other site 203124005402 ABC transporter signature motif; other site 203124005403 Walker B; other site 203124005404 D-loop; other site 203124005405 H-loop/switch region; other site 203124005406 ABC-2 type transporter; Region: ABC2_membrane; cl11417 203124005407 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124005408 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 203124005409 homotrimer interaction site [polypeptide binding]; other site 203124005410 putative active site [active] 203124005411 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 203124005412 hypothetical protein; Provisional; Region: PRK13560 203124005413 PAS domain S-box; Region: sensory_box; TIGR00229 203124005414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 203124005415 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 203124005416 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 203124005417 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 203124005418 PAS fold; Region: PAS_4; pfam08448 203124005419 PAS domain S-box; Region: sensory_box; TIGR00229 203124005420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 203124005421 cyclase homology domain; Region: CHD; cd07302 203124005422 nucleotidyl binding site; other site 203124005423 metal binding site [ion binding]; metal-binding site 203124005424 dimer interface [polypeptide binding]; other site 203124005425 HsdM N-terminal domain; Region: HsdM_N; pfam12161 203124005426 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 203124005427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124005428 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 203124005429 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 203124005430 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 203124005431 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 203124005432 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 203124005433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124005434 ATP binding site [chemical binding]; other site 203124005435 putative Mg++ binding site [ion binding]; other site 203124005436 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 203124005437 conserved cys residue [active] 203124005438 GTP-binding protein LepA; Provisional; Region: PRK05433 203124005439 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 203124005440 G1 box; other site 203124005441 putative GEF interaction site [polypeptide binding]; other site 203124005442 GTP/Mg2+ binding site [chemical binding]; other site 203124005443 Switch I region; other site 203124005444 G2 box; other site 203124005445 G3 box; other site 203124005446 Switch II region; other site 203124005447 G4 box; other site 203124005448 G5 box; other site 203124005449 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 203124005450 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 203124005451 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 203124005452 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 203124005453 HSP70 interaction site [polypeptide binding]; other site 203124005454 Probable transposase; Region: OrfB_IS605; pfam01385 203124005455 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 203124005456 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 203124005457 catalytic residue [active] 203124005458 putative FPP diphosphate binding site; other site 203124005459 putative FPP binding hydrophobic cleft; other site 203124005460 dimer interface [polypeptide binding]; other site 203124005461 putative IPP diphosphate binding site; other site 203124005462 Uncharacterized conserved protein [Function unknown]; Region: COG1624 203124005463 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 203124005464 diaminopimelate decarboxylase; Region: lysA; TIGR01048 203124005465 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 203124005466 active site 203124005467 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 203124005468 substrate binding site [chemical binding]; other site 203124005469 catalytic residues [active] 203124005470 dimer interface [polypeptide binding]; other site 203124005471 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 203124005472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 203124005473 Clp protease ATP binding subunit; Region: clpC; CHL00095 203124005474 Clp amino terminal domain; Region: Clp_N; pfam02861 203124005475 Clp amino terminal domain; Region: Clp_N; pfam02861 203124005476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124005477 Walker A motif; other site 203124005478 ATP binding site [chemical binding]; other site 203124005479 Walker B motif; other site 203124005480 arginine finger; other site 203124005481 UvrB/uvrC motif; Region: UVR; pfam02151 203124005482 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124005483 Walker A motif; other site 203124005484 ATP binding site [chemical binding]; other site 203124005485 Walker B motif; other site 203124005486 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 203124005487 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124005488 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 203124005489 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 203124005490 active site 203124005491 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124005492 putative active site [active] 203124005493 putative NTP binding site [chemical binding]; other site 203124005494 putative nucleic acid binding site [nucleotide binding]; other site 203124005495 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 203124005496 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 203124005497 C-terminal domain interface [polypeptide binding]; other site 203124005498 GSH binding site (G-site) [chemical binding]; other site 203124005499 dimer interface [polypeptide binding]; other site 203124005500 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178 203124005501 dimer interface [polypeptide binding]; other site 203124005502 N-terminal domain interface [polypeptide binding]; other site 203124005503 putative substrate binding pocket (H-site) [chemical binding]; other site 203124005504 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 203124005505 L-aspartate oxidase; Provisional; Region: PRK07395 203124005506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124005507 domain; Region: Succ_DH_flav_C; pfam02910 203124005508 Quinolinate synthetase A protein; Region: NadA; cl00420 203124005509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124005510 phosphoethanolamine N-methyltransferase; Region: PLN02336 203124005511 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 203124005512 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 203124005513 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 203124005514 putative NAD(P) binding site [chemical binding]; other site 203124005515 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 203124005516 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cd00250 203124005517 substrate binding pocket [chemical binding]; other site 203124005518 active site 203124005519 iron coordination sites [ion binding]; other site 203124005520 Isochorismatase family; Region: Isochorismatase; pfam00857 203124005521 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 203124005522 catalytic triad [active] 203124005523 conserved cis-peptide bond; other site 203124005524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124005525 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124005526 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124005527 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 203124005528 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 203124005529 Clostridial hydrophobic W; Region: ChW; cl02763 203124005530 Clostridial hydrophobic W; Region: ChW; cl02763 203124005531 Clostridial hydrophobic W; Region: ChW; cl02763 203124005532 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 203124005533 ThiC family; Region: ThiC; cl08031 203124005534 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 203124005535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 203124005536 motif II; other site 203124005537 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 203124005538 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 203124005539 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 203124005540 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 203124005541 FOG: WD40 repeat [General function prediction only]; Region: COG2319 203124005542 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124005543 structural tetrad; other site 203124005544 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124005545 structural tetrad; other site 203124005546 Phytochelatin synthase; Region: Phytochelatin; pfam05023 203124005547 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 203124005548 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124005549 domain; Region: Succ_DH_flav_C; pfam02910 203124005550 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 203124005551 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 203124005552 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 203124005553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124005554 NAD(P) binding site [chemical binding]; other site 203124005555 active site 203124005556 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 203124005557 replicative DNA helicase; Validated; Region: PRK07773 203124005558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124005559 active site 203124005560 DNA polymerase II large subunit; Provisional; Region: PRK14714 203124005561 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 203124005562 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 203124005563 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl09966 203124005564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124005565 Photosystem II protein; Region: PSII; cl08223 203124005566 Photosystem II protein; Region: PSII; cl08223 203124005567 Photosystem II protein; Region: PSII; cl08223 203124005568 Photosystem II protein; Region: PSII; cl08223 203124005569 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 203124005570 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 203124005571 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 203124005572 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 203124005573 phosphate binding site [ion binding]; other site 203124005574 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 203124005575 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 203124005576 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 203124005577 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 203124005578 substrate binding pocket [chemical binding]; other site 203124005579 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 203124005580 B12 binding site [chemical binding]; other site 203124005581 cobalt ligand [ion binding]; other site 203124005582 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 203124005583 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In...; Region: AroH; cd02185 203124005584 homotrimer interaction site [polypeptide binding]; other site 203124005585 active site 203124005586 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 203124005587 tandem repeat interface [polypeptide binding]; other site 203124005588 oligomer interface [polypeptide binding]; other site 203124005589 active site residues [active] 203124005590 EamA-like transporter family; Region: EamA; cl01037 203124005591 EamA-like transporter family; Region: EamA; cl01037 203124005592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694 203124005593 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 203124005594 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124005595 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 203124005596 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124005597 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 203124005598 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 203124005599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124005600 Walker A motif; other site 203124005601 ATP binding site [chemical binding]; other site 203124005602 Walker B motif; other site 203124005603 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124005604 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124005605 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 203124005606 metal binding site [ion binding]; metal-binding site 203124005607 active site 203124005608 I-site; other site 203124005609 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 203124005610 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 203124005611 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 203124005612 RNA binding site [nucleotide binding]; other site 203124005613 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 203124005614 RNA binding site [nucleotide binding]; other site 203124005615 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 203124005616 RNA binding site [nucleotide binding]; other site 203124005617 Dienelactone hydrolase family; Region: DLH; pfam01738 203124005618 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124005619 Predicted transcriptional regulators [Transcription]; Region: COG1725 203124005620 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 203124005621 DNA-binding site [nucleotide binding]; DNA binding site 203124005622 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124005623 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 203124005624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005625 binding surface 203124005626 TPR motif; other site 203124005627 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 203124005628 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 203124005629 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 203124005630 inhibitor-cofactor binding pocket; inhibition site 203124005631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124005632 catalytic residue [active] 203124005633 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 203124005634 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 203124005635 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 203124005636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124005637 NAD(P) binding site [chemical binding]; other site 203124005638 active site 203124005639 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 203124005640 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 203124005641 Ligand Binding Site [chemical binding]; other site 203124005642 Molecular Tunnel; other site 203124005643 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124005644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124005645 Mannosyltransferase putative; Region: Mannosyl_trans3; pfam11051 203124005646 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124005647 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124005648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005649 binding surface 203124005650 TPR motif; other site 203124005651 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005652 binding surface 203124005653 TPR motif; other site 203124005654 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005655 binding surface 203124005656 TPR motif; other site 203124005657 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124005658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005659 binding surface 203124005660 TPR motif; other site 203124005661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005662 TPR motif; other site 203124005663 binding surface 203124005664 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005665 binding surface 203124005666 TPR motif; other site 203124005667 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 203124005668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005669 binding surface 203124005670 TPR motif; other site 203124005671 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124005672 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 203124005673 tetramer (dimer of dimers) interface [polypeptide binding]; other site 203124005674 active site 203124005675 dimer interface [polypeptide binding]; other site 203124005676 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 203124005677 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 203124005678 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 203124005679 UvrD/REP helicase; Region: UvrD-helicase; cl14126 203124005680 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 203124005681 ligand binding site [chemical binding]; other site 203124005682 flexible hinge region; other site 203124005683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124005684 dimer interface [polypeptide binding]; other site 203124005685 phosphorylation site [posttranslational modification] 203124005686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124005687 ATP binding site [chemical binding]; other site 203124005688 Mg2+ binding site [ion binding]; other site 203124005689 G-X-G motif; other site 203124005690 signal recognition particle protein; Provisional; Region: PRK10867 203124005691 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 203124005692 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 203124005693 P loop; other site 203124005694 GTP binding site [chemical binding]; other site 203124005695 Signal peptide binding domain; Region: SRP_SPB; pfam02978 203124005696 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 203124005697 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 203124005698 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 203124005699 PhoH-like protein; Region: PhoH; cl12134 203124005700 ChuX-like family; Region: DUF1008; cl01509 203124005701 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124005702 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 203124005703 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124005704 hypothetical protein; Provisional; Region: PRK09866 203124005705 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 203124005706 Switch II region; other site 203124005707 G3 box; other site 203124005708 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 203124005709 G1 box; other site 203124005710 GTP/Mg2+ binding site [chemical binding]; other site 203124005711 Switch I region; other site 203124005712 G2 box; other site 203124005713 Switch II region; other site 203124005714 G3 box; other site 203124005715 G4 box; other site 203124005716 putative fimbrial chaperone protein; Provisional; Region: PRK09918 203124005717 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 203124005718 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 203124005719 DNA helicase, putative; Region: TIGR00376 203124005720 protein disaggregation chaperone; Provisional; Region: PRK10865 203124005721 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 203124005722 DNA helicase, putative; Region: TIGR00376 203124005723 Gram-positive type; Region: polC_Gram_pos; TIGR01405 203124005724 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 203124005725 putative active site [active] 203124005726 putative catalytic site [active] 203124005727 Protein kinase domain; Region: Pkinase; pfam00069 203124005728 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124005729 active site 203124005730 ATP binding site [chemical binding]; other site 203124005731 substrate binding site [chemical binding]; other site 203124005732 activation loop (A-loop); other site 203124005733 Predicted ATPase [General function prediction only]; Region: COG3899 203124005734 GAF domain; Region: GAF; cl00853 203124005735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 203124005736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124005737 ATP binding site [chemical binding]; other site 203124005738 Mg2+ binding site [ion binding]; other site 203124005739 G-X-G motif; other site 203124005740 Peptidase family M23; Region: Peptidase_M23; pfam01551 203124005741 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 203124005742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005743 TPR motif; other site 203124005744 binding surface 203124005745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005746 binding surface 203124005747 TPR motif; other site 203124005748 Cytochrome c; Region: Cytochrom_C; cl11414 203124005749 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 203124005750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 203124005751 Peptidase family M48; Region: Peptidase_M48; cl12018 203124005752 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 203124005753 putative active site pocket [active] 203124005754 dimerization interface [polypeptide binding]; other site 203124005755 putative catalytic residue [active] 203124005756 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 203124005757 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 203124005758 active site 203124005759 catalytic tetrad [active] 203124005760 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 203124005761 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 203124005762 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 203124005763 Lumazine binding domain; Region: Lum_binding; pfam00677 203124005764 Lumazine binding domain; Region: Lum_binding; pfam00677 203124005765 Hydrogenase formation hypA family; Region: HypD; cl12072 203124005766 Hydrogenase formation hypA family; Region: HypD; cl12072 203124005767 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 203124005768 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 203124005769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124005770 NAD(P) binding pocket [chemical binding]; other site 203124005771 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 203124005772 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 203124005773 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 203124005774 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 203124005775 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 203124005776 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 203124005777 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 203124005778 thiamine phosphate binding site [chemical binding]; other site 203124005779 active site 203124005780 pyrophosphate binding site [ion binding]; other site 203124005781 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 203124005782 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 203124005783 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124005784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124005785 Walker A motif; other site 203124005786 ATP binding site [chemical binding]; other site 203124005787 Walker B motif; other site 203124005788 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124005789 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 203124005790 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 203124005791 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 203124005792 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 203124005793 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124005794 Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium; plays a role in cell...; Region: CA; cl02468 203124005795 Ca2+ binding site [ion binding]; other site 203124005796 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124005797 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124005798 active site 203124005799 ATP binding site [chemical binding]; other site 203124005800 substrate binding site [chemical binding]; other site 203124005801 activation loop (A-loop); other site 203124005802 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 203124005803 putative active site [active] 203124005804 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 203124005805 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 203124005806 dimerization interface [polypeptide binding]; other site 203124005807 ATP binding site [chemical binding]; other site 203124005808 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 203124005809 dimerization interface [polypeptide binding]; other site 203124005810 ATP binding site [chemical binding]; other site 203124005811 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 203124005812 putative acyl-acceptor binding pocket; other site 203124005813 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 203124005814 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 203124005815 NAD(P) binding site [chemical binding]; other site 203124005816 catalytic residues [active] 203124005817 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 203124005818 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 203124005819 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 203124005820 Moco binding site; other site 203124005821 metal coordination site [ion binding]; other site 203124005822 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 203124005823 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 203124005824 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 203124005825 substrate binding site [chemical binding]; other site 203124005826 hexamer interface [polypeptide binding]; other site 203124005827 metal binding site [ion binding]; metal-binding site 203124005828 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 203124005829 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 203124005830 RDD family; Region: RDD; cl00746 203124005831 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 203124005832 protein binding site [polypeptide binding]; other site 203124005833 Protein kinase domain; Region: Pkinase; pfam00069 203124005834 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124005835 active site 203124005836 ATP binding site [chemical binding]; other site 203124005837 substrate binding site [chemical binding]; other site 203124005838 activation loop (A-loop); other site 203124005839 RDD family; Region: RDD; cl00746 203124005840 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 203124005841 phosphopeptide binding site; other site 203124005842 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 203124005843 phosphopeptide binding site; other site 203124005844 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 203124005845 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 203124005846 NurA domain; Region: NurA; cl09134 203124005847 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 203124005848 GUN4-like; Region: GUN4; pfam05419 203124005849 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124005850 chromosome segregation protein; Provisional; Region: PRK03918 203124005851 GUN4-like; Region: GUN4; pfam05419 203124005852 Transposase IS200 like; Region: Y1_Tnp; cl00848 203124005853 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 203124005854 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 203124005855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124005856 oligomerization interface [polypeptide binding]; other site 203124005857 active site 203124005858 NAD+ binding site [chemical binding]; other site 203124005859 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 203124005860 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]; Region: MET3; COG2046 203124005861 ATP-sulfurylase; Region: ATPS; cd00517 203124005862 active site 203124005863 HXXH motif; other site 203124005864 flexible loop; other site 203124005865 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 203124005866 active site 203124005867 trimer interface [polypeptide binding]; other site 203124005868 allosteric site; other site 203124005869 active site lid [active] 203124005870 hexamer (dimer of trimers) interface [polypeptide binding]; other site 203124005871 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 203124005872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124005873 NAD(P) binding site [chemical binding]; other site 203124005874 active site 203124005875 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 203124005876 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124005877 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 203124005878 A new structural DNA glycosylase; Region: AlkD_like; cl11434 203124005879 Active site [active] 203124005880 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124005881 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 203124005882 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 203124005883 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 203124005884 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 203124005885 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 203124005886 GST_C family, ECM4-like subfamily; composed of predominantly uncharacterized and taxonomically diverse proteins with similarity to the translation product of the Saccharomyces cerevisiae gene ECM4. ECM4, a gene of unknown function, is involved in cell...; Region: GST_C_ECM4_like; cd03190 203124005887 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 203124005888 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124005889 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 203124005890 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 203124005891 Flavoprotein; Region: Flavoprotein; cl08021 203124005892 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 203124005893 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 203124005894 DoxX; Region: DoxX; cl00976 203124005895 acetylornithine aminotransferase; Provisional; Region: PRK02627 203124005896 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 203124005897 inhibitor-cofactor binding pocket; inhibition site 203124005898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124005899 catalytic residue [active] 203124005900 Uncharacterised BCR, COG1649; Region: DUF187; pfam02638 203124005901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 203124005902 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 203124005903 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 203124005904 NAD(P) binding site [chemical binding]; other site 203124005905 catalytic residues [active] 203124005906 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 203124005907 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 203124005908 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 203124005909 synthetase active site [active] 203124005910 NTP binding site [chemical binding]; other site 203124005911 metal binding site [ion binding]; metal-binding site 203124005912 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 203124005913 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 203124005914 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 203124005915 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 203124005916 Walker A/P-loop; other site 203124005917 ATP binding site [chemical binding]; other site 203124005918 Q-loop/lid; other site 203124005919 ABC transporter signature motif; other site 203124005920 Walker B; other site 203124005921 D-loop; other site 203124005922 H-loop/switch region; other site 203124005923 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 203124005924 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 203124005925 Walker A/P-loop; other site 203124005926 ATP binding site [chemical binding]; other site 203124005927 Q-loop/lid; other site 203124005928 ABC transporter signature motif; other site 203124005929 Walker B; other site 203124005930 D-loop; other site 203124005931 H-loop/switch region; other site 203124005932 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 203124005933 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 203124005934 dimer interface [polypeptide binding]; other site 203124005935 FMN binding site [chemical binding]; other site 203124005936 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 203124005937 dimer interface [polypeptide binding]; other site 203124005938 glycine-pyridoxal phosphate binding site [chemical binding]; other site 203124005939 active site 203124005940 folate binding site [chemical binding]; other site 203124005941 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 203124005942 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 203124005943 Mg++ binding site [ion binding]; other site 203124005944 putative catalytic motif [active] 203124005945 substrate binding site [chemical binding]; other site 203124005946 competence damage-inducible protein A; Provisional; Region: PRK00549 203124005947 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 203124005948 putative MPT binding site; other site 203124005949 Competence-damaged protein; Region: CinA; cl00666 203124005950 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 203124005951 trimer interface [polypeptide binding]; other site 203124005952 active site 203124005953 dimer interface [polypeptide binding]; other site 203124005954 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 203124005955 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 203124005956 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 203124005957 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 203124005958 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 203124005959 Zn2+ binding site [ion binding]; other site 203124005960 Mg2+ binding site [ion binding]; other site 203124005961 hypothetical protein; Reviewed; Region: PRK00024 203124005962 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 203124005963 MPN+ (JAMM) motif; other site 203124005964 Zinc-binding site [ion binding]; other site 203124005965 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 203124005966 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 203124005967 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 203124005968 active site 203124005969 catalytic tetrad [active] 203124005970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005971 binding surface 203124005972 TPR motif; other site 203124005973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005974 binding surface 203124005975 TPR motif; other site 203124005976 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124005977 binding surface 203124005978 TPR motif; other site 203124005979 CHAT domain; Region: CHAT; cl02083 203124005980 Chromate transporter; Region: Chromate_transp; pfam02417 203124005981 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 203124005982 Chromate transporter; Region: Chromate_transp; pfam02417 203124005983 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124005984 excinuclease ABC subunit B; Provisional; Region: PRK05298 203124005985 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124005986 ATP binding site [chemical binding]; other site 203124005987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203124005988 nucleotide binding region [chemical binding]; other site 203124005989 ATP-binding site [chemical binding]; other site 203124005990 Ultra-violet resistance protein B; Region: UvrB; pfam12344 203124005991 UvrB/uvrC motif; Region: UVR; pfam02151 203124005992 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 203124005993 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 203124005994 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 203124005995 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 203124005996 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 203124005997 Cytochrome c; Region: Cytochrom_C; cl11414 203124005998 Cytochrome c; Region: Cytochrom_C; cl11414 203124005999 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 203124006000 HemX; Region: HemX; cl14667 203124006001 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 203124006002 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124006003 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 203124006004 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124006005 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 203124006006 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 203124006007 SLBB domain; Region: SLBB; pfam10531 203124006008 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 203124006009 eight transmembrane protein EpsH (proposed exosortase); Region: 8TM_EpsH; cl10495 203124006010 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 203124006011 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 203124006012 inhibitor-cofactor binding pocket; inhibition site 203124006013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124006014 catalytic residue [active] 203124006015 recombinase A; Provisional; Region: recA; PRK09354 203124006016 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 203124006017 hexamer interface [polypeptide binding]; other site 203124006018 Walker A motif; other site 203124006019 ATP binding site [chemical binding]; other site 203124006020 Walker B motif; other site 203124006021 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 203124006022 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 203124006023 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 203124006024 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 203124006025 secreted effector protein PipB2; Provisional; Region: PRK15196 203124006026 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 203124006027 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124006028 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124006029 arogenate dehydrogenase; Reviewed; Region: PRK07417 203124006030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124006031 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 203124006032 Domain of unknown function DUF20; Region: UPF0118; cl00465 203124006033 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 203124006034 catalytic triad [active] 203124006035 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 203124006036 active site 203124006037 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124006038 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 203124006039 active site 203124006040 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124006041 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124006042 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124006043 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124006044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006045 binding surface 203124006046 TPR motif; other site 203124006047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006048 binding surface 203124006049 TPR motif; other site 203124006050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006051 binding surface 203124006052 TPR motif; other site 203124006053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006054 binding surface 203124006055 TPR motif; other site 203124006056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006057 binding surface 203124006058 TPR motif; other site 203124006059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006060 TPR motif; other site 203124006061 binding surface 203124006062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006063 binding surface 203124006064 TPR motif; other site 203124006065 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 203124006066 Probable Catalytic site [active] 203124006067 metal binding site [ion binding]; metal-binding site 203124006068 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 203124006069 Probable Catalytic site [active] 203124006070 metal binding site [ion binding]; metal-binding site 203124006071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006072 binding surface 203124006073 TPR motif; other site 203124006074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006075 binding surface 203124006076 TPR motif; other site 203124006077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006078 binding surface 203124006079 TPR motif; other site 203124006080 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 203124006081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006082 binding surface 203124006083 TPR motif; other site 203124006084 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism]; Region: COG4421 203124006085 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124006086 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124006087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203124006088 putative substrate translocation pore; other site 203124006089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 203124006090 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 203124006091 trimer interface [polypeptide binding]; other site 203124006092 dimer interface [polypeptide binding]; other site 203124006093 putative active site [active] 203124006094 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 203124006095 aspartate aminotransferase; Provisional; Region: PRK08361 203124006096 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 203124006097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124006098 homodimer interface [polypeptide binding]; other site 203124006099 catalytic residue [active] 203124006100 integral membrane protein MviN; Region: mviN; TIGR01695 203124006101 Sugar fermentation stimulation protein; Region: SfsA; cl00647 203124006102 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 203124006103 active site 203124006104 substrate binding site [chemical binding]; other site 203124006105 Mg2+ binding site [ion binding]; other site 203124006106 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 203124006107 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 203124006108 substrate binding site [chemical binding]; other site 203124006109 ligand binding site [chemical binding]; other site 203124006110 Cache domain; Region: Cache_1; pfam02743 203124006111 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 203124006112 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 203124006113 dimerization interface [polypeptide binding]; other site 203124006114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124006115 dimer interface [polypeptide binding]; other site 203124006116 phosphorylation site [posttranslational modification] 203124006117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124006118 ATP binding site [chemical binding]; other site 203124006119 Mg2+ binding site [ion binding]; other site 203124006120 G-X-G motif; other site 203124006121 Response regulator receiver domain; Region: Response_reg; pfam00072 203124006122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124006123 active site 203124006124 phosphorylation site [posttranslational modification] 203124006125 intermolecular recognition site; other site 203124006126 dimerization interface [polypeptide binding]; other site 203124006127 cyclase homology domain; Region: CHD; cd07302 203124006128 nucleotidyl binding site; other site 203124006129 metal binding site [ion binding]; metal-binding site 203124006130 dimer interface [polypeptide binding]; other site 203124006131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124006132 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 203124006133 putative active site [active] 203124006134 putative metal binding residues [ion binding]; other site 203124006135 signature motif; other site 203124006136 putative dimer interface [polypeptide binding]; other site 203124006137 putative phosphate binding site [ion binding]; other site 203124006138 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 203124006139 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 203124006140 ATP-binding site [chemical binding]; other site 203124006141 Gluconate-6-phosphate binding site [chemical binding]; other site 203124006142 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 203124006143 putative substrate binding site [chemical binding]; other site 203124006144 putative ATP binding site [chemical binding]; other site 203124006145 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 203124006146 DNA binding residues [nucleotide binding] 203124006147 dimerization interface [polypeptide binding]; other site 203124006148 Tropomyosin like; Region: Tropomyosin_1; pfam12718 203124006149 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 203124006150 ligand binding site [chemical binding]; other site 203124006151 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 203124006152 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 203124006153 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 203124006154 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 203124006155 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 203124006156 glutamate-1-semialdehyde 2,1-aminomutase; Region: PLN02482 203124006157 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 203124006158 inhibitor-cofactor binding pocket; inhibition site 203124006159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124006160 catalytic residue [active] 203124006161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006162 binding surface 203124006163 TPR motif; other site 203124006164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006165 binding surface 203124006166 TPR motif; other site 203124006167 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 203124006168 Protein of unknown function (DUF520); Region: DUF520; cl00723 203124006169 MAPEG family; Region: MAPEG; cl09190 203124006170 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 203124006171 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124006172 DRTGG domain; Region: DRTGG; cl12147 203124006173 putative 5S ribosomal RNA; very low similarity 203124006174 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 203124006175 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 203124006176 DXD motif; other site 203124006177 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 203124006178 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 203124006179 CoA-ligase; Region: Ligase_CoA; pfam00549 203124006180 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 203124006181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124006182 CoA-ligase; Region: Ligase_CoA; pfam00549 203124006183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 203124006184 non-specific DNA binding site [nucleotide binding]; other site 203124006185 salt bridge; other site 203124006186 sequence-specific DNA binding site [nucleotide binding]; other site 203124006187 Protein of unknown function (DUF3768); Region: DUF3768; pfam12599 203124006188 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 203124006189 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 203124006190 active site 203124006191 catalytic tetrad [active] 203124006192 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 203124006193 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 203124006194 Clp amino terminal domain; Region: Clp_N; pfam02861 203124006195 Clp amino terminal domain; Region: Clp_N; pfam02861 203124006196 Clp amino terminal domain; Region: Clp_N; pfam02861 203124006197 Clp amino terminal domain; Region: Clp_N; pfam02861 203124006198 CHAT domain; Region: CHAT; cl02083 203124006199 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 203124006200 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 203124006201 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 203124006202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124006203 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 203124006204 Walker A motif; other site 203124006205 ATP binding site [chemical binding]; other site 203124006206 Walker B motif; other site 203124006207 arginine finger; other site 203124006208 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 203124006209 putative active site [active] 203124006210 putative metal binding site [ion binding]; other site 203124006211 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 203124006212 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 203124006213 putative ligand binding site [chemical binding]; other site 203124006214 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 203124006215 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170 203124006216 elongation factor G; Reviewed; Region: PRK12740 203124006217 G1 box; other site 203124006218 putative GEF interaction site [polypeptide binding]; other site 203124006219 GTP/Mg2+ binding site [chemical binding]; other site 203124006220 Switch I region; other site 203124006221 G2 box; other site 203124006222 G3 box; other site 203124006223 Switch II region; other site 203124006224 G4 box; other site 203124006225 G5 box; other site 203124006226 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 203124006227 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 203124006228 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 203124006229 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 203124006230 Cytochrome P450; Region: p450; cl12078 203124006231 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 203124006232 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 203124006233 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 203124006234 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 203124006235 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 203124006236 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 203124006237 CHAT domain; Region: CHAT; cl02083 203124006238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 203124006239 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 203124006240 active site 203124006241 catalytic site [active] 203124006242 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 203124006243 active site 203124006244 catalytic site [active] 203124006245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 203124006246 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 203124006247 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124006248 Ion transport protein; Region: Ion_trans; pfam00520 203124006249 Ion channel; Region: Ion_trans_2; cl11596 203124006250 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 203124006251 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 203124006252 Walker A/P-loop; other site 203124006253 ATP binding site [chemical binding]; other site 203124006254 Q-loop/lid; other site 203124006255 ABC transporter signature motif; other site 203124006256 Walker B; other site 203124006257 D-loop; other site 203124006258 H-loop/switch region; other site 203124006259 Cobalt transport protein; Region: CbiQ; cl00463 203124006260 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 203124006261 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124006262 Ferritin-like domain; Region: Ferritin; pfam00210 203124006263 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 203124006264 dinuclear metal binding motif [ion binding]; other site 203124006265 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 203124006266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124006267 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 203124006268 enolase; Provisional; Region: eno; PRK00077 203124006269 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 203124006270 dimer interface [polypeptide binding]; other site 203124006271 metal binding site [ion binding]; metal-binding site 203124006272 substrate binding pocket [chemical binding]; other site 203124006273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124006274 DevC protein; Region: devC; TIGR01185 203124006275 FtsX-like permease family; Region: FtsX; pfam02687 203124006276 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 203124006277 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 203124006278 Pantoate-beta-alanine ligase; Region: PanC; cd00560 203124006279 active site 203124006280 ATP-binding site [chemical binding]; other site 203124006281 pantoate-binding site; other site 203124006282 HXXH motif; other site 203124006283 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 203124006284 CMP-binding site; other site 203124006285 The sites determining sugar specificity; other site 203124006286 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 203124006287 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 203124006288 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 203124006289 dimerization interface [polypeptide binding]; other site 203124006290 putative ATP binding site [chemical binding]; other site 203124006291 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 203124006292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124006293 dimer interface [polypeptide binding]; other site 203124006294 conserved gate region; other site 203124006295 putative PBP binding loops; other site 203124006296 ABC-ATPase subunit interface; other site 203124006297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124006298 dimer interface [polypeptide binding]; other site 203124006299 conserved gate region; other site 203124006300 putative PBP binding loops; other site 203124006301 ABC-ATPase subunit interface; other site 203124006302 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 203124006303 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124006304 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 203124006305 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 203124006306 Walker A/P-loop; other site 203124006307 ATP binding site [chemical binding]; other site 203124006308 Q-loop/lid; other site 203124006309 ABC transporter signature motif; other site 203124006310 Walker B; other site 203124006311 D-loop; other site 203124006312 H-loop/switch region; other site 203124006313 TOBE domain; Region: TOBE_2; cl01440 203124006314 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 203124006315 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 203124006316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006317 binding surface 203124006318 TPR motif; other site 203124006319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006320 binding surface 203124006321 TPR motif; other site 203124006322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006323 TPR motif; other site 203124006324 binding surface 203124006325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006326 binding surface 203124006327 TPR motif; other site 203124006328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006329 binding surface 203124006330 TPR motif; other site 203124006331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006332 binding surface 203124006333 TPR motif; other site 203124006334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 203124006335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006336 binding surface 203124006337 TPR motif; other site 203124006338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 203124006339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006340 binding surface 203124006341 TPR motif; other site 203124006342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006343 binding surface 203124006344 TPR motif; other site 203124006345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006346 binding surface 203124006347 TPR motif; other site 203124006348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006349 binding surface 203124006350 TPR motif; other site 203124006351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006352 binding surface 203124006353 TPR motif; other site 203124006354 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 203124006355 putative active site [active] 203124006356 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 203124006357 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124006358 Walker A/P-loop; other site 203124006359 ATP binding site [chemical binding]; other site 203124006360 Q-loop/lid; other site 203124006361 ABC transporter signature motif; other site 203124006362 Walker B; other site 203124006363 D-loop; other site 203124006364 H-loop/switch region; other site 203124006365 TOBE domain; Region: TOBE_2; cl01440 203124006366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124006367 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 203124006368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 203124006369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124006370 dimer interface [polypeptide binding]; other site 203124006371 conserved gate region; other site 203124006372 putative PBP binding loops; other site 203124006373 ABC-ATPase subunit interface; other site 203124006374 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 203124006375 Uncharacterized protein conserved in bacteria (DUF2257); Region: DUF2257; cl01794 203124006376 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 203124006377 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 203124006378 Uncharacterised BCR, COG1649; Region: DUF187; pfam02638 203124006379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 203124006380 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 203124006381 MatE; Region: MatE; pfam01554 203124006382 MatE; Region: MatE; pfam01554 203124006383 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 203124006384 Protein kinase domain; Region: Pkinase; pfam00069 203124006385 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124006386 active site 203124006387 ATP binding site [chemical binding]; other site 203124006388 substrate binding site [chemical binding]; other site 203124006389 activation loop (A-loop); other site 203124006390 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124006391 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 203124006392 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124006393 active site 203124006394 ATP binding site [chemical binding]; other site 203124006395 substrate binding site [chemical binding]; other site 203124006396 activation loop (A-loop); other site 203124006397 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124006398 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 203124006399 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124006400 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 203124006401 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 203124006402 catalytic site [active] 203124006403 G-X2-G-X-G-K; other site 203124006404 Domain of unknown function (DUF370); Region: DUF370; cl00898 203124006405 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 203124006406 Domain of unknown function (DUF814); Region: DUF814; pfam05670 203124006407 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 203124006408 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 203124006409 Active Sites [active] 203124006410 Predicted esterase [General function prediction only]; Region: COG0627 203124006411 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124006412 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 203124006413 dimerization interface [polypeptide binding]; other site 203124006414 active site 203124006415 metal binding site [ion binding]; metal-binding site 203124006416 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 203124006417 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 203124006418 substrate binding site [chemical binding]; other site 203124006419 catalytic Zn binding site [ion binding]; other site 203124006420 NAD binding site [chemical binding]; other site 203124006421 structural Zn binding site [ion binding]; other site 203124006422 dimer interface [polypeptide binding]; other site 203124006423 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 203124006424 glucose-inhibited division protein A; Region: gidA; TIGR00136 203124006425 Nitrogen regulatory protein P-II; Region: P-II; cl00412 203124006426 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 203124006427 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 203124006428 PYR/PP interface [polypeptide binding]; other site 203124006429 dimer interface [polypeptide binding]; other site 203124006430 TPP binding site [chemical binding]; other site 203124006431 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 203124006432 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 203124006433 TPP-binding site [chemical binding]; other site 203124006434 dimer interface [polypeptide binding]; other site 203124006435 Sodium:solute symporter family; Region: SSF; cl00456 203124006436 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 203124006437 putative active site [active] 203124006438 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006439 binding surface 203124006440 TPR motif; other site 203124006441 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 203124006442 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 203124006443 Probable Catalytic site [active] 203124006444 metal binding site [ion binding]; metal-binding site 203124006445 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124006446 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124006447 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124006448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124006449 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 203124006450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006451 TPR motif; other site 203124006452 binding surface 203124006453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006454 binding surface 203124006455 TPR motif; other site 203124006456 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism]; Region: COG4421 203124006457 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 203124006458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006459 binding surface 203124006460 TPR motif; other site 203124006461 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 203124006462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006463 binding surface 203124006464 TPR motif; other site 203124006465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006466 binding surface 203124006467 TPR motif; other site 203124006468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006469 binding surface 203124006470 TPR motif; other site 203124006471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006472 binding surface 203124006473 TPR motif; other site 203124006474 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124006475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006476 binding surface 203124006477 TPR motif; other site 203124006478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006479 binding surface 203124006480 TPR motif; other site 203124006481 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124006482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006483 TPR motif; other site 203124006484 binding surface 203124006485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006486 binding surface 203124006487 TPR motif; other site 203124006488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006489 binding surface 203124006490 TPR motif; other site 203124006491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124006492 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124006493 Integrase core domain; Region: rve; cl01316 203124006494 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124006495 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 203124006496 active site 203124006497 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124006498 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124006499 active site 203124006500 ATP binding site [chemical binding]; other site 203124006501 substrate binding site [chemical binding]; other site 203124006502 activation loop (A-loop); other site 203124006503 Predicted ATPase [General function prediction only]; Region: COG3899 203124006504 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124006505 GAF domain; Region: GAF; cl00853 203124006506 cyclase homology domain; Region: CHD; cd07302 203124006507 nucleotidyl binding site; other site 203124006508 metal binding site [ion binding]; metal-binding site 203124006509 dimer interface [polypeptide binding]; other site 203124006510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006511 binding surface 203124006512 TPR motif; other site 203124006513 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124006514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006515 binding surface 203124006516 TPR motif; other site 203124006517 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006518 binding surface 203124006519 TPR motif; other site 203124006520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006521 binding surface 203124006522 TPR motif; other site 203124006523 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124006524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006525 binding surface 203124006526 TPR motif; other site 203124006527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006528 binding surface 203124006529 TPR motif; other site 203124006530 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124006531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006532 binding surface 203124006533 TPR motif; other site 203124006534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006535 binding surface 203124006536 TPR motif; other site 203124006537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006538 binding surface 203124006539 TPR motif; other site 203124006540 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124006541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006542 binding surface 203124006543 TPR motif; other site 203124006544 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006545 binding surface 203124006546 TPR motif; other site 203124006547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006548 binding surface 203124006549 TPR motif; other site 203124006550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006551 binding surface 203124006552 TPR motif; other site 203124006553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006554 binding surface 203124006555 TPR motif; other site 203124006556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006557 binding surface 203124006558 TPR motif; other site 203124006559 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 203124006560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006561 binding surface 203124006562 TPR motif; other site 203124006563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006564 binding surface 203124006565 TPR motif; other site 203124006566 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124006567 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 203124006568 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 203124006569 catalytic residues [active] 203124006570 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 203124006571 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 203124006572 Tetramer interface [polypeptide binding]; other site 203124006573 Active site [active] 203124006574 FMN-binding site [chemical binding]; other site 203124006575 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 203124006576 Photosystem II 10 kDa phosphoprotein; Region: PsbH; cl02951 203124006577 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 203124006578 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 203124006579 putative active site [active] 203124006580 catalytic residue [active] 203124006581 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 203124006582 CTP synthetase; Validated; Region: pyrG; PRK05380 203124006583 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 203124006584 Catalytic site [active] 203124006585 Active site [active] 203124006586 UTP binding site [chemical binding]; other site 203124006587 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 203124006588 active site 203124006589 putative oxyanion hole; other site 203124006590 catalytic triad [active] 203124006591 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 203124006592 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 203124006593 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 203124006594 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 203124006595 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 203124006596 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 203124006597 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 203124006598 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 203124006599 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 203124006600 substrate binding site [chemical binding]; other site 203124006601 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 203124006602 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 203124006603 G1 box; other site 203124006604 GTP/Mg2+ binding site [chemical binding]; other site 203124006605 Switch I region; other site 203124006606 G2 box; other site 203124006607 G3 box; other site 203124006608 Switch II region; other site 203124006609 G4 box; other site 203124006610 G5 box; other site 203124006611 Nucleoside recognition; Region: Gate; cl00486 203124006612 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 203124006613 Nucleoside recognition; Region: Gate; cl00486 203124006614 FeoA domain; Region: FeoA; cl00838 203124006615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124006616 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 203124006617 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 203124006618 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 203124006619 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 203124006620 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 203124006621 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 203124006622 Ribosome-binding factor A; Region: RBFA; cl00542 203124006623 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 203124006624 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 203124006625 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124006626 Creatinine amidohydrolase; Region: Creatininase; cl00618 203124006627 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 203124006628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124006629 active site 203124006630 phosphorylation site [posttranslational modification] 203124006631 intermolecular recognition site; other site 203124006632 dimerization interface [polypeptide binding]; other site 203124006633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 203124006634 DNA binding site [nucleotide binding] 203124006635 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 203124006636 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 203124006637 active site 203124006638 metal binding site [ion binding]; metal-binding site 203124006639 DNA binding site [nucleotide binding] 203124006640 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 203124006641 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 203124006642 G1 box; other site 203124006643 putative GEF interaction site [polypeptide binding]; other site 203124006644 GTP/Mg2+ binding site [chemical binding]; other site 203124006645 Switch I region; other site 203124006646 G2 box; other site 203124006647 G3 box; other site 203124006648 Switch II region; other site 203124006649 G4 box; other site 203124006650 G5 box; other site 203124006651 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 203124006652 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 203124006653 ligand binding site [chemical binding]; other site 203124006654 flexible hinge region; other site 203124006655 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 203124006656 FeS/SAM binding site; other site 203124006657 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 203124006658 Nucleoside recognition; Region: Gate; cl00486 203124006659 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 203124006660 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 203124006661 putative NAD(P) binding site [chemical binding]; other site 203124006662 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 203124006663 Predicted ATPase [General function prediction only]; Region: COG4637 203124006664 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124006665 Walker A/P-loop; other site 203124006666 ATP binding site [chemical binding]; other site 203124006667 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 203124006668 ABC transporter signature motif; other site 203124006669 Walker B; other site 203124006670 D-loop; other site 203124006671 H-loop/switch region; other site 203124006672 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 203124006673 classical (c) SDRs; Region: SDR_c; cd05233 203124006674 NAD(P) binding site [chemical binding]; other site 203124006675 active site 203124006676 primosome assembly protein PriA; Validated; Region: PRK05580 203124006677 primosome assembly protein PriA; Validated; Region: PRK05580 203124006678 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124006679 ATP binding site [chemical binding]; other site 203124006680 putative Mg++ binding site [ion binding]; other site 203124006681 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 203124006682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 203124006683 A functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site...; Region: Peptidase_M14-like_8; cd06905 203124006684 putative active site [active] 203124006685 Zn-binding site [ion binding]; other site 203124006686 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 203124006687 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 203124006688 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124006689 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 203124006690 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 203124006691 Fatty acid desaturase; Region: FA_desaturase; pfam00487 203124006692 putative di-iron ligands [ion binding]; other site 203124006693 pyruvate kinase; Provisional; Region: PRK06354 203124006694 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 203124006695 domain interfaces; other site 203124006696 active site 203124006697 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 203124006698 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 203124006699 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 203124006700 FeS/SAM binding site; other site 203124006701 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 203124006702 putative acyl-acceptor binding pocket; other site 203124006703 DNA repair and recombination protein RadA; Validated; Region: radA; PRK04301 203124006704 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 203124006705 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 203124006706 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 203124006707 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 203124006708 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 203124006709 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 203124006710 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 203124006711 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 203124006712 DNA binding site [nucleotide binding] 203124006713 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 203124006714 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 203124006715 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 203124006716 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 203124006717 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 203124006718 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 203124006719 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 203124006720 RPB12 interaction site [polypeptide binding]; other site 203124006721 RPB1 interaction site [polypeptide binding]; other site 203124006722 RPB10 interaction site [polypeptide binding]; other site 203124006723 RPB11 interaction site [polypeptide binding]; other site 203124006724 RPB3 interaction site [polypeptide binding]; other site 203124006725 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 203124006726 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 203124006727 active site 203124006728 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 203124006729 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 203124006730 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 203124006731 NAD binding site [chemical binding]; other site 203124006732 dimerization interface [polypeptide binding]; other site 203124006733 product binding site; other site 203124006734 substrate binding site [chemical binding]; other site 203124006735 zinc binding site [ion binding]; other site 203124006736 catalytic residues [active] 203124006737 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 203124006738 hydrolase, alpha/beta fold family protein; Region: PLN02679 203124006739 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 203124006740 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 203124006741 NADP-binding site; other site 203124006742 homotetramer interface [polypeptide binding]; other site 203124006743 substrate binding site [chemical binding]; other site 203124006744 homodimer interface [polypeptide binding]; other site 203124006745 active site 203124006746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124006747 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 203124006748 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006749 binding surface 203124006750 TPR motif; other site 203124006751 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006752 binding surface 203124006753 TPR motif; other site 203124006754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006755 binding surface 203124006756 TPR motif; other site 203124006757 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124006758 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124006759 active site 203124006760 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124006761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006762 binding surface 203124006763 TPR motif; other site 203124006764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006765 binding surface 203124006766 TPR motif; other site 203124006767 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124006768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006769 binding surface 203124006770 TPR motif; other site 203124006771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006772 binding surface 203124006773 TPR motif; other site 203124006774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 203124006775 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124006776 Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091 203124006777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124006778 S-adenosylmethionine binding site [chemical binding]; other site 203124006779 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 203124006780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124006781 dimer interface [polypeptide binding]; other site 203124006782 conserved gate region; other site 203124006783 putative PBP binding loops; other site 203124006784 ABC-ATPase subunit interface; other site 203124006785 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124006786 GTPase Era; Reviewed; Region: era; PRK00089 203124006787 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 203124006788 G1 box; other site 203124006789 GTP/Mg2+ binding site [chemical binding]; other site 203124006790 Switch I region; other site 203124006791 G2 box; other site 203124006792 Switch II region; other site 203124006793 G3 box; other site 203124006794 G4 box; other site 203124006795 G5 box; other site 203124006796 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 203124006797 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 203124006798 Phosphotransferase enzyme family; Region: APH; pfam01636 203124006799 active site 203124006800 ATP binding site [chemical binding]; other site 203124006801 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 203124006802 substrate binding site [chemical binding]; other site 203124006803 O-methyltransferase; Region: Methyltransf_2; pfam00891 203124006804 peptide synthase; Provisional; Region: PRK12467 203124006805 Condensation domain; Region: Condensation; cl09290 203124006806 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 203124006807 Phosphopantetheine attachment site; Region: PP-binding; cl09936 203124006808 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124006809 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 203124006810 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 203124006811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124006812 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 203124006813 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 203124006814 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 203124006815 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 203124006816 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 203124006817 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 203124006818 EamA-like transporter family; Region: EamA; cl01037 203124006819 Sodium:solute symporter family; Region: SSF; cl00456 203124006820 hypothetical protein; Provisional; Region: PRK06849 203124006821 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 203124006822 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 203124006823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124006824 2-epi-5-epi-valiolone synthase (EEVS); Region: EEVS; cd08199 203124006825 active site 203124006826 metal binding site [ion binding]; metal-binding site 203124006827 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124006828 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 203124006829 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124006830 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124006831 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124006832 peptide chain release factor 1; Validated; Region: prfA; PRK00591 203124006833 RF-1 domain; Region: RF-1; cl02875 203124006834 RF-1 domain; Region: RF-1; cl02875 203124006835 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 203124006836 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 203124006837 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 203124006838 23S rRNA interface [nucleotide binding]; other site 203124006839 L3 interface [polypeptide binding]; other site 203124006840 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 203124006841 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 203124006842 dimerization interface 3.5A [polypeptide binding]; other site 203124006843 active site 203124006844 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 203124006845 RNA polymerase alpha subunit; Region: rpoA; CHL00013 203124006846 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 203124006847 alphaNTD homodimer interface [polypeptide binding]; other site 203124006848 alphaNTD - beta interaction site [polypeptide binding]; other site 203124006849 alphaNTD - beta' interaction site [polypeptide binding]; other site 203124006850 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 203124006851 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 203124006852 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 203124006853 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 203124006854 rRNA binding site [nucleotide binding]; other site 203124006855 predicted 30S ribosome binding site; other site 203124006856 adenylate kinase; Reviewed; Region: adk; PRK00279 203124006857 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 203124006858 AMP-binding site [chemical binding]; other site 203124006859 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 203124006860 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 203124006861 SecY translocase; Region: SecY; pfam00344 203124006862 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 203124006863 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 203124006864 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 203124006865 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 203124006866 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 203124006867 5S rRNA interface [nucleotide binding]; other site 203124006868 L27 interface [polypeptide binding]; other site 203124006869 23S rRNA interface [nucleotide binding]; other site 203124006870 L5 interface [polypeptide binding]; other site 203124006871 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 203124006872 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 203124006873 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 203124006874 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 203124006875 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 203124006876 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 203124006877 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 203124006878 KOW motif; Region: KOW; cl00354 203124006879 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 203124006880 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 203124006881 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 203124006882 23S rRNA interface [nucleotide binding]; other site 203124006883 putative translocon interaction site; other site 203124006884 signal recognition particle (SRP54) interaction site; other site 203124006885 L23 interface [polypeptide binding]; other site 203124006886 trigger factor interaction site; other site 203124006887 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 203124006888 23S rRNA interface [nucleotide binding]; other site 203124006889 5S rRNA interface [nucleotide binding]; other site 203124006890 putative antibiotic binding site [chemical binding]; other site 203124006891 L25 interface [polypeptide binding]; other site 203124006892 L27 interface [polypeptide binding]; other site 203124006893 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 203124006894 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 203124006895 G-X-X-G motif; other site 203124006896 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 203124006897 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 203124006898 putative translocon binding site; other site 203124006899 protein-rRNA interface [nucleotide binding]; other site 203124006900 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 203124006901 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 203124006902 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 203124006903 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 203124006904 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 203124006905 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 203124006906 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 203124006907 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 203124006908 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 203124006909 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 203124006910 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 203124006911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124006912 Walker A motif; other site 203124006913 ATP binding site [chemical binding]; other site 203124006914 Walker B motif; other site 203124006915 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 203124006916 RxxxH motif; other site 203124006917 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 203124006918 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 203124006919 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 203124006920 serine O-acetyltransferase; Region: cysE; TIGR01172 203124006921 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 203124006922 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 203124006923 trimer interface [polypeptide binding]; other site 203124006924 active site 203124006925 substrate binding site [chemical binding]; other site 203124006926 CoA binding site [chemical binding]; other site 203124006927 Golgin subfamily A member 5; Region: Golgin_A5; pfam09787 203124006928 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 203124006929 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 203124006930 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124006931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006932 binding surface 203124006933 TPR motif; other site 203124006934 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 203124006935 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 203124006936 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124006937 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124006938 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 203124006939 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 203124006940 DctM-like transporters; Region: DctM; pfam06808 203124006941 Cupin superfamily protein; Region: Cupin_4; pfam08007 203124006942 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 203124006943 putative dimer interface [polypeptide binding]; other site 203124006944 putative [2Fe-2S] cluster binding site [ion binding]; other site 203124006945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 203124006946 GUN4-like; Region: GUN4; pfam05419 203124006947 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 203124006948 active site 203124006949 nucleotide binding site [chemical binding]; other site 203124006950 HIGH motif; other site 203124006951 KMSKS motif; other site 203124006952 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 203124006953 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 203124006954 putative metal binding site [ion binding]; other site 203124006955 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 203124006956 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 203124006957 TPP-binding site; other site 203124006958 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 203124006959 PYR/PP interface [polypeptide binding]; other site 203124006960 dimer interface [polypeptide binding]; other site 203124006961 TPP binding site [chemical binding]; other site 203124006962 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 203124006963 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124006964 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124006965 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124006966 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 203124006967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006968 binding surface 203124006969 TPR motif; other site 203124006970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006971 binding surface 203124006972 TPR motif; other site 203124006973 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 203124006974 Domain of unknown function (DUF205); Region: DUF205; cl00410 203124006975 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 203124006976 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 203124006977 Domain of unknown function DUF140; Region: DUF140; cl00510 203124006978 Integrase core domain; Region: rve; cl01316 203124006979 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124006980 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 203124006981 putative dimer interface [polypeptide binding]; other site 203124006982 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 203124006983 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 203124006984 putative dimer interface [polypeptide binding]; other site 203124006985 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 203124006986 putative dimer interface [polypeptide binding]; other site 203124006987 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 203124006988 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124006989 TIGR03032 family protein; Region: TIGR03032 203124006990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124006991 binding surface 203124006992 TPR motif; other site 203124006993 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124006994 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124006995 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 203124006996 Phage integrase family; Region: Phage_integrase; pfam00589 203124006997 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 203124006998 DNA binding site [nucleotide binding] 203124006999 Int/Topo IB signature motif; other site 203124007000 active site 203124007001 Domain of unknown function (DUF205); Region: DUF205; cl00410 203124007002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 203124007003 Domain of unknown function (DUF205); Region: DUF205; cl00410 203124007004 Integrase core domain; Region: rve; cl01316 203124007005 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 203124007006 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism]; Region: COG4421 203124007007 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 203124007008 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 203124007009 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 203124007010 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124007011 Walker A/P-loop; other site 203124007012 ATP binding site [chemical binding]; other site 203124007013 Q-loop/lid; other site 203124007014 ABC transporter signature motif; other site 203124007015 Walker B; other site 203124007016 D-loop; other site 203124007017 H-loop/switch region; other site 203124007018 KpsF/GutQ family protein; Region: kpsF; TIGR00393 203124007019 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 203124007020 putative active site [active] 203124007021 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 203124007022 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124007023 active site 203124007024 Phosphotransferase enzyme family; Region: APH; pfam01636 203124007025 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 203124007026 active site 203124007027 ATP binding site [chemical binding]; other site 203124007028 substrate binding site [chemical binding]; other site 203124007029 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 203124007030 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 203124007031 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 203124007032 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 203124007033 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 203124007034 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 203124007035 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 203124007036 putative active site [active] 203124007037 catalytic site [active] 203124007038 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124007039 ATP binding site [chemical binding]; other site 203124007040 putative Mg++ binding site [ion binding]; other site 203124007041 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 203124007042 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203124007043 nucleotide binding region [chemical binding]; other site 203124007044 ATP-binding site [chemical binding]; other site 203124007045 Cytochrome P450; Region: p450; cl12078 203124007046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124007047 S-adenosylmethionine binding site [chemical binding]; other site 203124007048 EamA-like transporter family; Region: EamA; cl01037 203124007049 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 203124007050 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 203124007051 substrate binding pocket [chemical binding]; other site 203124007052 active site 203124007053 iron coordination sites [ion binding]; other site 203124007054 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 203124007055 active site 203124007056 iron coordination sites [ion binding]; other site 203124007057 substrate binding pocket [chemical binding]; other site 203124007058 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 203124007059 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 203124007060 active site 203124007061 catalytic tetrad [active] 203124007062 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 203124007063 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 203124007064 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 203124007065 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 203124007066 FMN binding site [chemical binding]; other site 203124007067 active site 203124007068 substrate binding site [chemical binding]; other site 203124007069 catalytic residue [active] 203124007070 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 203124007071 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 203124007072 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism]; Region: COG4421 203124007073 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124007074 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124007075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007076 TPR motif; other site 203124007077 binding surface 203124007078 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 203124007079 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 203124007080 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 203124007081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 203124007082 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 203124007083 Active site [active] 203124007084 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 203124007085 phosphopeptide binding site; other site 203124007086 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 203124007087 metal ion-dependent adhesion site (MIDAS); other site 203124007088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007089 TPR motif; other site 203124007090 binding surface 203124007091 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007092 binding surface 203124007093 TPR motif; other site 203124007094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007095 binding surface 203124007096 TPR motif; other site 203124007097 Bacterial SH3 domain; Region: SH3_3; cl02551 203124007098 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124007099 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124007100 active site 203124007101 ATP binding site [chemical binding]; other site 203124007102 substrate binding site [chemical binding]; other site 203124007103 activation loop (A-loop); other site 203124007104 Clp protease ATP binding subunit; Region: clpC; CHL00095 203124007105 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124007106 Response regulator receiver domain; Region: Response_reg; pfam00072 203124007107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124007108 active site 203124007109 phosphorylation site [posttranslational modification] 203124007110 intermolecular recognition site; other site 203124007111 dimerization interface [polypeptide binding]; other site 203124007112 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124007113 GAF domain; Region: GAF; cl00853 203124007114 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124007115 GAF domain; Region: GAF; cl00853 203124007116 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 203124007117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124007118 dimer interface [polypeptide binding]; other site 203124007119 phosphorylation site [posttranslational modification] 203124007120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124007121 ATP binding site [chemical binding]; other site 203124007122 Mg2+ binding site [ion binding]; other site 203124007123 G-X-G motif; other site 203124007124 Response regulator receiver domain; Region: Response_reg; pfam00072 203124007125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124007126 active site 203124007127 phosphorylation site [posttranslational modification] 203124007128 intermolecular recognition site; other site 203124007129 dimerization interface [polypeptide binding]; other site 203124007130 cyclase homology domain; Region: CHD; cd07302 203124007131 nucleotidyl binding site; other site 203124007132 metal binding site [ion binding]; metal-binding site 203124007133 dimer interface [polypeptide binding]; other site 203124007134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203124007135 Coenzyme A binding pocket [chemical binding]; other site 203124007136 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 203124007137 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124007138 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 203124007139 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 203124007140 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 203124007141 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 203124007142 NAD(P) binding site [chemical binding]; other site 203124007143 putative active site [active] 203124007144 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 203124007145 ATP-NAD kinase; Region: NAD_kinase; pfam01513 203124007146 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 203124007147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124007148 active site 203124007149 phosphorylation site [posttranslational modification] 203124007150 intermolecular recognition site; other site 203124007151 dimerization interface [polypeptide binding]; other site 203124007152 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 203124007153 DNA binding site [nucleotide binding] 203124007154 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 203124007155 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 203124007156 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-...; Region: AGAT_like; cd06451 203124007157 homodimer interface [polypeptide binding]; other site 203124007158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124007159 catalytic residue [active] 203124007160 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 203124007161 active site 203124007162 ribulose/triose binding site [chemical binding]; other site 203124007163 phosphate binding site [ion binding]; other site 203124007164 substrate (anthranilate) binding pocket [chemical binding]; other site 203124007165 product (indole) binding pocket [chemical binding]; other site 203124007166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124007167 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 203124007168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124007169 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 203124007170 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 203124007171 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 203124007172 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 203124007173 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 203124007174 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 203124007175 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124007176 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 203124007177 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 203124007178 hinge; other site 203124007179 active site 203124007180 H+ Antiporter protein; Region: 2A0121; TIGR00900 203124007181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203124007182 putative substrate translocation pore; other site 203124007183 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124007184 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 203124007185 acyl-CoA synthetase; Validated; Region: PRK05850 203124007186 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 203124007187 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 203124007188 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 203124007189 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 203124007190 catalytic triad [active] 203124007191 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 203124007192 30S subunit binding site; other site 203124007193 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 203124007194 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 203124007195 dimer interface [polypeptide binding]; other site 203124007196 ssDNA binding site [nucleotide binding]; other site 203124007197 tetramer (dimer of dimers) interface [polypeptide binding]; other site 203124007198 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124007199 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 203124007200 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 203124007201 active site 203124007202 Substrate binding site [chemical binding]; other site 203124007203 Mg++ binding site [ion binding]; other site 203124007204 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 203124007205 putative trimer interface [polypeptide binding]; other site 203124007206 putative CoA binding site [chemical binding]; other site 203124007207 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 203124007208 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 203124007209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124007210 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 203124007211 active site 203124007212 putative substrate binding region [chemical binding]; other site 203124007213 FOG: CBS domain [General function prediction only]; Region: COG0517 203124007214 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a...; Region: CBS_pair_M50_like; cd04801 203124007215 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 203124007216 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 203124007217 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 203124007218 OstA-like protein; Region: OstA; cl00844 203124007219 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 203124007220 CpeS-like protein; Region: CpeS; pfam09367 203124007221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 203124007222 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 203124007223 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124007224 structural tetrad; other site 203124007225 FOG: WD40 repeat [General function prediction only]; Region: COG2319 203124007226 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124007227 structural tetrad; other site 203124007228 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 203124007229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124007230 dimer interface [polypeptide binding]; other site 203124007231 phosphorylation site [posttranslational modification] 203124007232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124007233 ATP binding site [chemical binding]; other site 203124007234 Mg2+ binding site [ion binding]; other site 203124007235 G-X-G motif; other site 203124007236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203124007237 BT1 family; Region: BT1; pfam03092 203124007238 putative substrate translocation pore; other site 203124007239 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 203124007240 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 203124007241 coronin; Provisional; Region: PTZ00421 203124007242 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124007243 structural tetrad; other site 203124007244 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124007245 structural tetrad; other site 203124007246 Condensation domain; Region: Condensation; cl09290 203124007247 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 203124007248 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 203124007249 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 203124007250 metal binding site [ion binding]; metal-binding site 203124007251 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 203124007252 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 203124007253 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 203124007254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124007255 Walker A/P-loop; other site 203124007256 ATP binding site [chemical binding]; other site 203124007257 Q-loop/lid; other site 203124007258 ABC transporter signature motif; other site 203124007259 Walker B; other site 203124007260 D-loop; other site 203124007261 H-loop/switch region; other site 203124007262 TOBE domain; Region: TOBE_2; cl01440 203124007263 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 203124007264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124007265 dimer interface [polypeptide binding]; other site 203124007266 conserved gate region; other site 203124007267 putative PBP binding loops; other site 203124007268 ABC-ATPase subunit interface; other site 203124007269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124007270 dimer interface [polypeptide binding]; other site 203124007271 conserved gate region; other site 203124007272 putative PBP binding loops; other site 203124007273 ABC-ATPase subunit interface; other site 203124007274 magnesium chelatase subunit H; Provisional; Region: PRK12493 203124007275 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 203124007276 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 203124007277 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 203124007278 Ligand binding site [chemical binding]; other site 203124007279 Putative Catalytic site [active] 203124007280 DXD motif; other site 203124007281 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 203124007282 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 203124007283 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124007284 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 203124007285 active site 203124007286 catalytic triad [active] 203124007287 oxyanion hole [active] 203124007288 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 203124007289 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 203124007290 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 203124007291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007292 binding surface 203124007293 TPR motif; other site 203124007294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007295 binding surface 203124007296 TPR motif; other site 203124007297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124007298 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 203124007299 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 203124007300 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 203124007301 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 203124007302 active site 203124007303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007304 binding surface 203124007305 TPR motif; other site 203124007306 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124007307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007308 binding surface 203124007309 TPR motif; other site 203124007310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007311 binding surface 203124007312 TPR motif; other site 203124007313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007314 TPR motif; other site 203124007315 binding surface 203124007316 Rhamnan synthesis protein F; Region: RgpF; cl01529 203124007317 Phycobilisome protein; Region: Phycobilisome; cl08227 203124007318 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 203124007319 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 203124007320 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 203124007321 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 203124007322 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 203124007323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124007324 ATP binding site [chemical binding]; other site 203124007325 Mg2+ binding site [ion binding]; other site 203124007326 G-X-G motif; other site 203124007327 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 203124007328 Response regulator receiver domain; Region: Response_reg; pfam00072 203124007329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124007330 active site 203124007331 phosphorylation site [posttranslational modification] 203124007332 intermolecular recognition site; other site 203124007333 dimerization interface [polypeptide binding]; other site 203124007334 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 203124007335 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 203124007336 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 203124007337 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 203124007338 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 203124007339 Response regulator receiver domain; Region: Response_reg; pfam00072 203124007340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124007341 active site 203124007342 phosphorylation site [posttranslational modification] 203124007343 intermolecular recognition site; other site 203124007344 dimerization interface [polypeptide binding]; other site 203124007345 Response regulator receiver domain; Region: Response_reg; pfam00072 203124007346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124007347 active site 203124007348 phosphorylation site [posttranslational modification] 203124007349 intermolecular recognition site; other site 203124007350 dimerization interface [polypeptide binding]; other site 203124007351 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 203124007352 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 203124007353 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 203124007354 Ligand Binding Site [chemical binding]; other site 203124007355 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 203124007356 FtsH Extracellular; Region: FtsH_ext; pfam06480 203124007357 cell division protein; Validated; Region: ftsH; CHL00176 203124007358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124007359 Walker A motif; other site 203124007360 ATP binding site [chemical binding]; other site 203124007361 Walker B motif; other site 203124007362 arginine finger; other site 203124007363 Peptidase family M41; Region: Peptidase_M41; pfam01434 203124007364 Peptidase family M23; Region: Peptidase_M23; pfam01551 203124007365 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 203124007366 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124007367 putative ADP-binding pocket [chemical binding]; other site 203124007368 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007369 binding surface 203124007370 TPR motif; other site 203124007371 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 203124007372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007373 binding surface 203124007374 TPR motif; other site 203124007375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007376 binding surface 203124007377 TPR motif; other site 203124007378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007379 binding surface 203124007380 TPR motif; other site 203124007381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007382 binding surface 203124007383 TPR motif; other site 203124007384 CHAT domain; Region: CHAT; cl02083 203124007385 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 203124007386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124007387 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 203124007388 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124007389 ATP binding site [chemical binding]; other site 203124007390 putative Mg++ binding site [ion binding]; other site 203124007391 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203124007392 nucleotide binding region [chemical binding]; other site 203124007393 ATP-binding site [chemical binding]; other site 203124007394 RQC domain; Region: RQC; pfam09382 203124007395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 203124007396 HRDC domain; Region: HRDC; cl02578 203124007397 CHAT domain; Region: CHAT; cl02083 203124007398 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 203124007399 haemagglutination activity domain; Region: Haemagg_act; cl05436 203124007400 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 203124007401 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 203124007402 Surface antigen; Region: Bac_surface_Ag; cl03097 203124007403 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 203124007404 active site 203124007405 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 203124007406 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 203124007407 putative substrate binding region [chemical binding]; other site 203124007408 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 203124007409 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 203124007410 minor groove reading motif; other site 203124007411 helix-hairpin-helix signature motif; other site 203124007412 substrate binding pocket [chemical binding]; other site 203124007413 active site 203124007414 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 203124007415 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 203124007416 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 203124007417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203124007418 putative substrate translocation pore; other site 203124007419 Major Facilitator Superfamily; Region: MFS_1; pfam07690 203124007420 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 203124007421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124007422 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 203124007423 Membrane transport protein; Region: Mem_trans; cl09117 203124007424 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007425 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007426 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 203124007427 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007428 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007429 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007430 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007431 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007432 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 203124007433 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124007434 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 203124007435 B1 nucleotide binding pocket [chemical binding]; other site 203124007436 B2 nucleotide binding pocket [chemical binding]; other site 203124007437 CAS motifs; other site 203124007438 Active site [active] 203124007439 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 203124007440 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 203124007441 putative NADP binding site [chemical binding]; other site 203124007442 putative substrate binding site [chemical binding]; other site 203124007443 active site 203124007444 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 203124007445 active site 203124007446 adenylosuccinate synthetase; Provisional; Region: PRK01117 203124007447 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 203124007448 GDP-binding site [chemical binding]; other site 203124007449 ACT binding site; other site 203124007450 IMP binding site; other site 203124007451 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 203124007452 5S rRNA interface [nucleotide binding]; other site 203124007453 CTC domain interface; other site 203124007454 L16 interface [polypeptide binding]; other site 203124007455 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 203124007456 substrate binding site [chemical binding]; other site 203124007457 ATP binding site [chemical binding]; other site 203124007458 Probable transposase; Region: OrfB_IS605; pfam01385 203124007459 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 203124007460 Probable transposase; Region: OrfB_IS605; pfam01385 203124007461 aspartate aminotransferase; Provisional; Region: PRK08361 203124007462 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 203124007463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124007464 homodimer interface [polypeptide binding]; other site 203124007465 catalytic residue [active] 203124007466 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 203124007467 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 203124007468 active site 203124007469 metal binding site [ion binding]; metal-binding site 203124007470 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 203124007471 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 203124007472 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 203124007473 active site 203124007474 ATP binding site [chemical binding]; other site 203124007475 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 203124007476 Active site [active] 203124007477 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 203124007478 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 203124007479 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124007480 Walker A/P-loop; other site 203124007481 ATP binding site [chemical binding]; other site 203124007482 Q-loop/lid; other site 203124007483 ABC transporter signature motif; other site 203124007484 Walker B; other site 203124007485 D-loop; other site 203124007486 H-loop/switch region; other site 203124007487 Smr domain; Region: Smr; cl02619 203124007488 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 203124007489 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 203124007490 active site 203124007491 metal binding site [ion binding]; metal-binding site 203124007492 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 203124007493 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124007494 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 203124007495 putative active site [active] 203124007496 putative NTP binding site [chemical binding]; other site 203124007497 putative nucleic acid binding site [nucleotide binding]; other site 203124007498 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 203124007499 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 203124007500 active site 203124007501 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 203124007502 phosphate binding site [ion binding]; other site 203124007503 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 203124007504 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 203124007505 catalytic residues [active] 203124007506 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 203124007507 catalytic residues [active] 203124007508 short chain dehydrogenase; Provisional; Region: PRK06181 203124007509 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 203124007510 putative NAD(P) binding site [chemical binding]; other site 203124007511 homotetramer interface [polypeptide binding]; other site 203124007512 active site 203124007513 homodimer interface [polypeptide binding]; other site 203124007514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007515 binding surface 203124007516 TPR motif; other site 203124007517 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007518 binding surface 203124007519 TPR motif; other site 203124007520 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 203124007521 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 203124007522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007523 binding surface 203124007524 TPR motif; other site 203124007525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007526 binding surface 203124007527 TPR motif; other site 203124007528 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 203124007529 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 203124007530 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cl10034 203124007531 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 203124007532 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 203124007533 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 203124007534 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 203124007535 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 203124007536 active site 203124007537 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 203124007538 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 203124007539 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 203124007540 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 203124007541 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 203124007542 active site 203124007543 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 203124007544 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 203124007545 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 203124007546 metal ion-dependent adhesion site (MIDAS); other site 203124007547 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 203124007548 metal ion-dependent adhesion site (MIDAS); other site 203124007549 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 203124007550 metal ion-dependent adhesion site (MIDAS); other site 203124007551 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 203124007552 phosphopeptide binding site; other site 203124007553 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 203124007554 active site 203124007555 substrate binding site [chemical binding]; other site 203124007556 activation loop (A-loop); other site 203124007557 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 203124007558 Active site [active] 203124007559 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124007560 active site 203124007561 ATP binding site [chemical binding]; other site 203124007562 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124007563 substrate binding site [chemical binding]; other site 203124007564 activation loop (A-loop); other site 203124007565 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 203124007566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007567 TPR motif; other site 203124007568 binding surface 203124007569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007570 TPR motif; other site 203124007571 binding surface 203124007572 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 203124007573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 203124007574 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 203124007575 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 203124007576 UvrB/uvrC motif; Region: UVR; pfam02151 203124007577 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 203124007578 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 203124007579 translation initiation factor Sui1; Validated; Region: PRK06824 203124007580 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cd00474 203124007581 Predicted RNA interaction site [nucleotide binding]; other site 203124007582 putative binding site; other site 203124007583 Mutations affecting start-site selection; other site 203124007584 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 203124007585 Protein kinase domain; Region: Pkinase; pfam00069 203124007586 active site 203124007587 ATP binding site [chemical binding]; other site 203124007588 substrate binding site [chemical binding]; other site 203124007589 activation loop (A-loop); other site 203124007590 mercuric reductase; Validated; Region: PRK06370 203124007591 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124007592 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 203124007593 CHAT domain; Region: CHAT; cl02083 203124007594 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124007595 GUN4-like; Region: GUN4; pfam05419 203124007596 Peptidase family M23; Region: Peptidase_M23; pfam01551 203124007597 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 203124007598 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 203124007599 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 203124007600 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 203124007601 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 203124007602 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 203124007603 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 203124007604 ABC-ATPase subunit interface; other site 203124007605 dimer interface [polypeptide binding]; other site 203124007606 putative PBP binding regions; other site 203124007607 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 203124007608 active site 203124007609 catalytic residues [active] 203124007610 von Willebrand factor type D domain; Region: VWD; cl02516 203124007611 NifU-like domain; Region: NifU; cl00484 203124007612 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 203124007613 This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are...; Region: H2MP_Cyano-H2up; cd06063 203124007614 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 203124007615 nickel binding site [ion binding]; other site 203124007616 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 203124007617 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 203124007618 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 203124007619 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 203124007620 putative metal binding site [ion binding]; other site 203124007621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007622 TPR motif; other site 203124007623 binding surface 203124007624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007625 binding surface 203124007626 TPR motif; other site 203124007627 Fasciclin domain; Region: Fasciclin; cl02663 203124007628 Fasciclin domain; Region: Fasciclin; cl02663 203124007629 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 203124007630 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 203124007631 GTP/Mg2+ binding site [chemical binding]; other site 203124007632 G4 box; other site 203124007633 G5 box; other site 203124007634 G1 box; other site 203124007635 Switch I region; other site 203124007636 G2 box; other site 203124007637 G3 box; other site 203124007638 Switch II region; other site 203124007639 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 203124007640 Ligand Binding Site [chemical binding]; other site 203124007641 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 203124007642 substrate binding site [chemical binding]; other site 203124007643 hinge regions; other site 203124007644 ADP binding site [chemical binding]; other site 203124007645 catalytic site [active] 203124007646 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124007647 Clp protease ATP binding subunit; Region: clpC; CHL00095 203124007648 Clp amino terminal domain; Region: Clp_N; pfam02861 203124007649 Clp amino terminal domain; Region: Clp_N; pfam02861 203124007650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124007651 Walker A motif; other site 203124007652 ATP binding site [chemical binding]; other site 203124007653 Walker B motif; other site 203124007654 arginine finger; other site 203124007655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124007656 Walker A motif; other site 203124007657 ATP binding site [chemical binding]; other site 203124007658 Walker B motif; other site 203124007659 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 203124007660 septum formation inhibitor; Reviewed; Region: minC; PRK00513 203124007661 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 203124007662 septum-site determining protein; Validated; Region: minD; CHL00175 203124007663 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 203124007664 P-loop; other site 203124007665 ADP binding residues [chemical binding]; other site 203124007666 Switch I; other site 203124007667 Switch II; other site 203124007668 Septum formation topological specificity factor MinE; Region: MinE; cl00538 203124007669 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 203124007670 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 203124007671 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 203124007672 alpha subunit interaction interface [polypeptide binding]; other site 203124007673 Walker A motif; other site 203124007674 ATP binding site [chemical binding]; other site 203124007675 Walker B motif; other site 203124007676 inhibitor binding site; inhibition site 203124007677 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 203124007678 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 203124007679 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 203124007680 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 203124007681 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 203124007682 CP12 domain; Region: CP12; cl14670 203124007683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 203124007684 FIST N domain; Region: FIST; pfam08495 203124007685 FIST C domain; Region: FIST_C; pfam10442 203124007686 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 203124007687 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 203124007688 active site 203124007689 metal binding site [ion binding]; metal-binding site 203124007690 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 203124007691 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 203124007692 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124007693 Walker A/P-loop; other site 203124007694 ATP binding site [chemical binding]; other site 203124007695 Q-loop/lid; other site 203124007696 ABC transporter signature motif; other site 203124007697 Walker B; other site 203124007698 D-loop; other site 203124007699 H-loop/switch region; other site 203124007700 ABC transporter; Region: ABC_tran_2; pfam12848 203124007701 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 203124007702 Response regulator receiver domain; Region: Response_reg; pfam00072 203124007703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124007704 active site 203124007705 phosphorylation site [posttranslational modification] 203124007706 intermolecular recognition site; other site 203124007707 dimerization interface [polypeptide binding]; other site 203124007708 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 203124007709 putative hexamer interface [polypeptide binding]; other site 203124007710 putative hexagonal pore; other site 203124007711 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 203124007712 Hexamer interface [polypeptide binding]; other site 203124007713 Hexagonal pore residue; other site 203124007714 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 203124007715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203124007716 Coenzyme A binding pocket [chemical binding]; other site 203124007717 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 203124007718 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 203124007719 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 203124007720 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 203124007721 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124007722 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124007723 active site 203124007724 ATP binding site [chemical binding]; other site 203124007725 substrate binding site [chemical binding]; other site 203124007726 activation loop (A-loop); other site 203124007727 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 203124007728 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007729 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007730 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007731 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007732 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007733 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 203124007734 NifU-like domain; Region: NifU; cl00484 203124007735 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 203124007736 metal binding site 2 [ion binding]; metal-binding site 203124007737 putative DNA binding helix; other site 203124007738 metal binding site 1 [ion binding]; metal-binding site 203124007739 dimer interface [polypeptide binding]; other site 203124007740 structural Zn2+ binding site [ion binding]; other site 203124007741 Predicted membrane protein [Function unknown]; Region: COG4327; cl01781 203124007742 Sodium:solute symporter family; Region: SSF; cl00456 203124007743 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 203124007744 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 203124007745 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124007746 Walker A/P-loop; other site 203124007747 ATP binding site [chemical binding]; other site 203124007748 Q-loop/lid; other site 203124007749 ABC transporter signature motif; other site 203124007750 Walker B; other site 203124007751 D-loop; other site 203124007752 H-loop/switch region; other site 203124007753 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124007754 sodium/calcium exchanger 1; Region: caca; TIGR00845 203124007755 Calx-beta domain; Region: Calx-beta; cl02522 203124007756 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 203124007757 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 203124007758 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 203124007759 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 203124007760 active site 203124007761 Cache domain; Region: Cache_1; pfam02743 203124007762 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 203124007763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124007764 dimer interface [polypeptide binding]; other site 203124007765 phosphorylation site [posttranslational modification] 203124007766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124007767 ATP binding site [chemical binding]; other site 203124007768 Mg2+ binding site [ion binding]; other site 203124007769 G-X-G motif; other site 203124007770 Response regulator receiver domain; Region: Response_reg; pfam00072 203124007771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124007772 active site 203124007773 phosphorylation site [posttranslational modification] 203124007774 intermolecular recognition site; other site 203124007775 dimerization interface [polypeptide binding]; other site 203124007776 cyclase homology domain; Region: CHD; cd07302 203124007777 nucleotidyl binding site; other site 203124007778 metal binding site [ion binding]; metal-binding site 203124007779 dimer interface [polypeptide binding]; other site 203124007780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124007781 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 203124007782 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007783 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007784 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007785 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007786 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007787 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007788 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 203124007789 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124007790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124007791 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 203124007792 Protein kinase domain; Region: Pkinase; pfam00069 203124007793 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124007794 active site 203124007795 ATP binding site [chemical binding]; other site 203124007796 substrate binding site [chemical binding]; other site 203124007797 activation loop (A-loop); other site 203124007798 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 203124007799 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 203124007800 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 203124007801 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124007802 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 203124007803 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 203124007804 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 203124007805 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 203124007806 homotrimer interface [polypeptide binding]; other site 203124007807 Walker A motif; other site 203124007808 GTP binding site [chemical binding]; other site 203124007809 Walker B motif; other site 203124007810 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 203124007811 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 203124007812 active site 203124007813 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 203124007814 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 203124007815 putative metal binding site [ion binding]; other site 203124007816 putative acyl transferase; Provisional; Region: PRK10502 203124007817 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 203124007818 putative trimer interface [polypeptide binding]; other site 203124007819 putative active site [active] 203124007820 putative substrate binding site [chemical binding]; other site 203124007821 putative CoA binding site [chemical binding]; other site 203124007822 CemA family; Region: CemA; cl03855 203124007823 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 203124007824 catalytic residues [active] 203124007825 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 203124007826 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 203124007827 NAD(P) binding site [chemical binding]; other site 203124007828 homotetramer interface [polypeptide binding]; other site 203124007829 homodimer interface [polypeptide binding]; other site 203124007830 active site 203124007831 An uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the the M14 family of metallocarboxypeptidases. This subgroup includes Pseudomonas aeruginosa AotO and related proteins. ASTE...; Region: M14_PaAOTO_like; cd06250 203124007832 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 203124007833 putative active site [active] 203124007834 Zn-binding site [ion binding]; other site 203124007835 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 203124007836 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 203124007837 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 203124007838 HIGH motif; other site 203124007839 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 203124007840 active site 203124007841 KMSKS motif; other site 203124007842 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 203124007843 tRNA binding surface [nucleotide binding]; other site 203124007844 anticodon binding site; other site 203124007845 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 203124007846 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 203124007847 active site 203124007848 catalytic triad [active] 203124007849 oxyanion hole [active] 203124007850 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 203124007851 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 203124007852 Proline dehydrogenase; Region: Pro_dh; cl03282 203124007853 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 203124007854 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 203124007855 Glutamate binding site [chemical binding]; other site 203124007856 homodimer interface [polypeptide binding]; other site 203124007857 NAD binding site [chemical binding]; other site 203124007858 catalytic residues [active] 203124007859 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 203124007860 Protein of unknown function (DUF990); Region: DUF990; cl01496 203124007861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124007862 S-adenosylmethionine binding site [chemical binding]; other site 203124007863 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65); Region: PSRP-3_Ycf65; cl04793 203124007864 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 203124007865 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 203124007866 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 203124007867 classical (c) SDRs; Region: SDR_c; cd05233 203124007868 NAD(P) binding site [chemical binding]; other site 203124007869 active site 203124007870 Domain of unknown function DUF21; Region: DUF21; pfam01595 203124007871 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 203124007872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124007873 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 203124007874 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 203124007875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124007876 active site 203124007877 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 203124007878 RHS Repeat; Region: RHS_repeat; cl11982 203124007879 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 203124007880 RHS Repeat; Region: RHS_repeat; cl11982 203124007881 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 203124007882 Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium; plays a role in cell...; Region: CA; cd00031 203124007883 Ca2+ binding site [ion binding]; other site 203124007884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124007885 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 203124007886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124007887 ATP binding site [chemical binding]; other site 203124007888 putative Mg++ binding site [ion binding]; other site 203124007889 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203124007890 nucleotide binding region [chemical binding]; other site 203124007891 ATP-binding site [chemical binding]; other site 203124007892 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 203124007893 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 203124007894 conserved cys residue [active] 203124007895 Uncharacterised BCR, COG1649; Region: DUF187; pfam02638 203124007896 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 203124007897 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base...; Region: nuc_hydro_TvIAG; cd02647 203124007898 active site 203124007899 dimerization interface [polypeptide binding]; other site 203124007900 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 203124007901 Uncharacterized conserved protein [Function unknown]; Region: COG3391 203124007902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 203124007903 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124007904 Transposase [DNA replication, recombination, and repair]; Region: COG5433 203124007905 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 203124007906 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124007907 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124007908 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 203124007909 dimer interface [polypeptide binding]; other site 203124007910 putative metal binding site [ion binding]; other site 203124007911 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 203124007912 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 203124007913 Recombinase; Region: Recombinase; pfam07508 203124007914 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 203124007915 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 203124007916 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 203124007917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 203124007918 Survival protein SurE; Region: SurE; cl00448 203124007919 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 203124007920 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 203124007921 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 203124007922 dimer interface [polypeptide binding]; other site 203124007923 motif 1; other site 203124007924 active site 203124007925 motif 2; other site 203124007926 motif 3; other site 203124007927 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 203124007928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124007929 Walker A motif; other site 203124007930 ATP binding site [chemical binding]; other site 203124007931 Walker B motif; other site 203124007932 arginine finger; other site 203124007933 Peptidase family M41; Region: Peptidase_M41; pfam01434 203124007934 Transposase IS200 like; Region: Y1_Tnp; cl00848 203124007935 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 203124007936 haemagglutination activity domain; Region: Haemagg_act; cl05436 203124007937 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 203124007938 Surface antigen; Region: Bac_surface_Ag; cl03097 203124007939 CHAT domain; Region: CHAT; cl02083 203124007940 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 203124007941 haemagglutination activity domain; Region: Haemagg_act; cl05436 203124007942 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 203124007943 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 203124007944 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 203124007945 Surface antigen; Region: Bac_surface_Ag; cl03097 203124007946 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 203124007947 Clp amino terminal domain; Region: Clp_N; pfam02861 203124007948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124007949 Walker A motif; other site 203124007950 ATP binding site [chemical binding]; other site 203124007951 Walker B motif; other site 203124007952 arginine finger; other site 203124007953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124007954 Walker A motif; other site 203124007955 ATP binding site [chemical binding]; other site 203124007956 Walker B motif; other site 203124007957 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 203124007958 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 203124007959 dimer interface [polypeptide binding]; other site 203124007960 active site 203124007961 metal binding site [ion binding]; metal-binding site 203124007962 glutathione binding site [chemical binding]; other site 203124007963 lipoyl synthase; Provisional; Region: PRK12928 203124007964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 203124007965 Response regulator receiver domain; Region: Response_reg; pfam00072 203124007966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124007967 active site 203124007968 phosphorylation site [posttranslational modification] 203124007969 intermolecular recognition site; other site 203124007970 dimerization interface [polypeptide binding]; other site 203124007971 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 203124007972 putative ribose interaction site [chemical binding]; other site 203124007973 putative ADP binding site [chemical binding]; other site 203124007974 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 203124007975 metal ion-dependent adhesion site (MIDAS); other site 203124007976 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007977 binding surface 203124007978 TPR motif; other site 203124007979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007980 binding surface 203124007981 TPR motif; other site 203124007982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007983 binding surface 203124007984 TPR motif; other site 203124007985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007986 binding surface 203124007987 TPR motif; other site 203124007988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124007989 binding surface 203124007990 TPR motif; other site 203124007991 CHAT domain; Region: CHAT; cl02083 203124007992 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 203124007993 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 203124007994 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 203124007995 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 203124007996 Rubredoxin; Region: Rubredoxin; pfam00301 203124007997 iron binding site [ion binding]; other site 203124007998 Ycf48-like protein; Provisional; Region: PRK13684 203124007999 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 203124008000 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 203124008001 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 203124008002 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 203124008003 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 203124008004 PsbJ; Region: PsbJ; cl09469 203124008005 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 203124008006 metal ion-dependent adhesion site (MIDAS); other site 203124008007 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 203124008008 Active site [active] 203124008009 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124008010 active site 203124008011 ATP binding site [chemical binding]; other site 203124008012 substrate binding site [chemical binding]; other site 203124008013 activation loop (A-loop); other site 203124008014 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 203124008015 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 203124008016 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 203124008017 B12 binding site [chemical binding]; other site 203124008018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 203124008019 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 203124008020 putative hydrophobic ligand binding site [chemical binding]; other site 203124008021 Uncharacterized conserved protein [Function unknown]; Region: COG3586 203124008022 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 203124008023 putative homotetramer interface [polypeptide binding]; other site 203124008024 putative homodimer interface [polypeptide binding]; other site 203124008025 putative metal binding site [ion binding]; other site 203124008026 putative homodimer-homodimer interface [polypeptide binding]; other site 203124008027 putative allosteric switch controlling residues; other site 203124008028 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 203124008029 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124008030 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 203124008031 protein binding site [polypeptide binding]; other site 203124008032 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124008033 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124008034 seryl-tRNA synthetase; Provisional; Region: PRK05431 203124008035 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 203124008036 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 203124008037 dimer interface [polypeptide binding]; other site 203124008038 active site 203124008039 motif 1; other site 203124008040 motif 2; other site 203124008041 motif 3; other site 203124008042 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124008043 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 203124008044 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 203124008045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124008046 homodimer interface [polypeptide binding]; other site 203124008047 catalytic residue [active] 203124008048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 203124008049 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124008050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008051 binding surface 203124008052 TPR motif; other site 203124008053 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124008054 DEAD-like helicases superfamily; Region: DEXDc; smart00487 203124008055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124008056 ATP binding site [chemical binding]; other site 203124008057 putative Mg++ binding site [ion binding]; other site 203124008058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203124008059 nucleotide binding region [chemical binding]; other site 203124008060 ATP-binding site [chemical binding]; other site 203124008061 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 203124008062 lipoprotein signal peptidase; Provisional; Region: PRK14787 203124008063 BioY family; Region: BioY; cl00560 203124008064 biotin synthase; Validated; Region: PRK06256 203124008065 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 203124008066 FeS/SAM binding site; other site 203124008067 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 203124008068 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124008069 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124008070 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124008071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 203124008072 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 203124008073 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 203124008074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124008075 dimer interface [polypeptide binding]; other site 203124008076 conserved gate region; other site 203124008077 putative PBP binding loops; other site 203124008078 ABC-ATPase subunit interface; other site 203124008079 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 203124008080 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 203124008081 Walker A/P-loop; other site 203124008082 ATP binding site [chemical binding]; other site 203124008083 Q-loop/lid; other site 203124008084 ABC transporter signature motif; other site 203124008085 Walker B; other site 203124008086 D-loop; other site 203124008087 H-loop/switch region; other site 203124008088 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 203124008089 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 203124008090 sulfite reductase subunit beta; Provisional; Region: PRK13504 203124008091 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 203124008092 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 203124008093 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 203124008094 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 203124008095 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 203124008096 active site 203124008097 metal binding site [ion binding]; metal-binding site 203124008098 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 203124008099 active site 203124008100 metal binding site [ion binding]; metal-binding site 203124008101 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 203124008102 active site 203124008103 metal binding site [ion binding]; metal-binding site 203124008104 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 203124008105 active site 203124008106 metal binding site [ion binding]; metal-binding site 203124008107 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 203124008108 active site 203124008109 metal binding site [ion binding]; metal-binding site 203124008110 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 203124008111 active site 203124008112 metal binding site [ion binding]; metal-binding site 203124008113 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 203124008114 active site 203124008115 metal binding site [ion binding]; metal-binding site 203124008116 Integral membrane protein DUF92; Region: DUF92; cl00793 203124008117 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 203124008118 PPIC-type PPIASE domain; Region: Rotamase; cl08278 203124008119 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 203124008120 putative FMN binding site [chemical binding]; other site 203124008121 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 203124008122 NmrA-like family; Region: NmrA; pfam05368 203124008123 NAD(P) binding site [chemical binding]; other site 203124008124 putative active site [active] 203124008125 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 203124008126 putative phosphate binding site [ion binding]; other site 203124008127 putative catalytic site [active] 203124008128 active site 203124008129 metal binding site A [ion binding]; metal-binding site 203124008130 DNA binding site [nucleotide binding] 203124008131 putative AP binding site [nucleotide binding]; other site 203124008132 putative metal binding site B [ion binding]; other site 203124008133 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124008134 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 203124008135 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124008136 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 203124008137 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 203124008138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008139 binding surface 203124008140 TPR motif; other site 203124008141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008142 binding surface 203124008143 TPR motif; other site 203124008144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008145 binding surface 203124008146 TPR motif; other site 203124008147 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 203124008148 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124008149 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 203124008150 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124008151 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 203124008152 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124008153 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 203124008154 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124008155 putative lyase; Provisional; Region: PRK09687 203124008156 secreted effector protein PipB; Provisional; Region: PRK15197 203124008157 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124008158 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 203124008159 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 203124008160 iron-sulfur cluster [ion binding]; other site 203124008161 [2Fe-2S] cluster binding site [ion binding]; other site 203124008162 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 203124008163 hydrophobic ligand binding site; other site 203124008164 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124008165 GAF domain; Region: GAF; cl00853 203124008166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124008167 dimer interface [polypeptide binding]; other site 203124008168 phosphorylation site [posttranslational modification] 203124008169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124008170 ATP binding site [chemical binding]; other site 203124008171 Mg2+ binding site [ion binding]; other site 203124008172 G-X-G motif; other site 203124008173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124008174 ATP binding site [chemical binding]; other site 203124008175 Mg2+ binding site [ion binding]; other site 203124008176 G-X-G motif; other site 203124008177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124008178 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 203124008179 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 203124008180 iron-sulfur cluster [ion binding]; other site 203124008181 [2Fe-2S] cluster binding site [ion binding]; other site 203124008182 Uncharacterized conserved protein [Function unknown]; Region: COG3349 203124008183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124008184 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124008185 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 203124008186 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124008187 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 203124008188 Walker A motif; other site 203124008189 ATP binding site [chemical binding]; other site 203124008190 Walker B motif; other site 203124008191 arginine finger; other site 203124008192 Uncharacterized conserved protein [Function unknown]; Region: COG4933 203124008193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 203124008194 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 203124008195 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 203124008196 HIGH motif; other site 203124008197 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 203124008198 active site 203124008199 KMSKS motif; other site 203124008200 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 203124008201 tRNA binding surface [nucleotide binding]; other site 203124008202 anticodon binding site; other site 203124008203 photosystem I P subunit (PSI-P); Region: PLN02777 203124008204 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 203124008205 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 203124008206 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124008207 Domain of unknown function (DUF205); Region: DUF205; cl00410 203124008208 phosphoenolpyruvate synthase; Validated; Region: PRK06241 203124008209 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 203124008210 hypothetical protein; Provisional; Region: PRK05865 203124008211 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 203124008212 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124008213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124008214 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 203124008215 ligand binding site [chemical binding]; other site 203124008216 flexible hinge region; other site 203124008217 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 203124008218 active site 203124008219 dimer interfaces [polypeptide binding]; other site 203124008220 catalytic residues [active] 203124008221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124008222 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 203124008223 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 203124008224 Ligand binding site [chemical binding]; other site 203124008225 Putative Catalytic site [active] 203124008226 DXD motif; other site 203124008227 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124008228 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 203124008229 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 203124008230 putative switch regulator; other site 203124008231 non-specific DNA interactions [nucleotide binding]; other site 203124008232 DNA binding site [nucleotide binding] 203124008233 sequence specific DNA binding site [nucleotide binding]; other site 203124008234 putative cAMP binding site [chemical binding]; other site 203124008235 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 203124008236 Protein of unknown function, DUF393; Region: DUF393; cl01136 203124008237 Domain of unknown function (DUF477); Region: DUF477; cl01535 203124008238 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 203124008239 active site 203124008240 putative DNA-binding cleft [nucleotide binding]; other site 203124008241 dimer interface [polypeptide binding]; other site 203124008242 DNA repair protein RadA; Region: sms; TIGR00416 203124008243 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124008244 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 203124008245 dihydrodipicolinate reductase; Provisional; Region: PRK00048 203124008246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124008247 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 203124008248 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 203124008249 calcium/proton exchanger (cax); Region: cax; TIGR00378 203124008250 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 203124008251 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 203124008252 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 203124008253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 203124008254 motif II; other site 203124008255 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 203124008256 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124008257 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 203124008258 putative active site [active] 203124008259 putative NTP binding site [chemical binding]; other site 203124008260 putative nucleic acid binding site [nucleotide binding]; other site 203124008261 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 203124008262 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons...; Region: RT_like; cl02808 203124008263 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons...; Region: RT_like; cl02808 203124008264 ParB-like nuclease domain; Region: ParBc; cl02129 203124008265 ParB-like nuclease domain; Region: ParBc; cl02129 203124008266 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 203124008267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124008268 AAA-like domain; Region: AAA_10; pfam12846 203124008269 Zonular occludens toxin (Zot); Region: Zot; cl01706 203124008270 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 203124008271 MutS domain I; Region: MutS_I; pfam01624 203124008272 MutS domain II; Region: MutS_II; pfam05188 203124008273 MutS family domain IV; Region: MutS_IV; pfam05190 203124008274 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 203124008275 Walker A/P-loop; other site 203124008276 ATP binding site [chemical binding]; other site 203124008277 Q-loop/lid; other site 203124008278 ABC transporter signature motif; other site 203124008279 Walker B; other site 203124008280 D-loop; other site 203124008281 H-loop/switch region; other site 203124008282 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 203124008283 Phycobilisome protein; Region: Phycobilisome; cl08227 203124008284 Phycobilisome protein; Region: Phycobilisome; cl08227 203124008285 phosphoribulokinase; Provisional; Region: PRK07429 203124008286 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 203124008287 Active site [active] 203124008288 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 203124008289 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 203124008290 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 203124008291 dimerization interface [polypeptide binding]; other site 203124008292 FAD binding pocket [chemical binding]; other site 203124008293 FAD binding motif [chemical binding]; other site 203124008294 catalytic residues [active] 203124008295 NAD binding pocket [chemical binding]; other site 203124008296 phosphate binding motif [ion binding]; other site 203124008297 beta-alpha-beta structure motif; other site 203124008298 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 203124008299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 203124008300 motif II; other site 203124008301 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 203124008302 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124008303 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124008304 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 203124008305 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 203124008306 active site 203124008307 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124008308 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 203124008309 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 203124008310 P-loop; other site 203124008311 Magnesium ion binding site [ion binding]; other site 203124008312 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 203124008313 Magnesium ion binding site [ion binding]; other site 203124008314 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124008315 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 203124008316 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124008317 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124008318 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 203124008319 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 203124008320 DNA binding residues [nucleotide binding] 203124008321 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 203124008322 catalytic residues [active] 203124008323 catalytic nucleophile [active] 203124008324 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 203124008325 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 203124008326 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 203124008327 Walker A/P-loop; other site 203124008328 ATP binding site [chemical binding]; other site 203124008329 Q-loop/lid; other site 203124008330 ABC transporter signature motif; other site 203124008331 Walker B; other site 203124008332 D-loop; other site 203124008333 H-loop/switch region; other site 203124008334 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 203124008335 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 203124008336 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 203124008337 putative ligand binding site [chemical binding]; other site 203124008338 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 203124008339 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 203124008340 CHAT domain; Region: CHAT; cl02083 203124008341 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 203124008342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124008343 NAD(P) binding pocket [chemical binding]; other site 203124008344 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124008345 DoxX; Region: DoxX; cl00976 203124008346 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 203124008347 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124008348 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124008349 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124008350 active site 203124008351 ATP binding site [chemical binding]; other site 203124008352 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124008353 substrate binding site [chemical binding]; other site 203124008354 activation loop (A-loop); other site 203124008355 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124008356 structural tetrad; other site 203124008357 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 203124008358 FAD binding domain; Region: FAD_binding_4; pfam01565 203124008359 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 203124008360 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124008361 ATP binding site [chemical binding]; other site 203124008362 putative Mg++ binding site [ion binding]; other site 203124008363 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203124008364 nucleotide binding region [chemical binding]; other site 203124008365 ATP-binding site [chemical binding]; other site 203124008366 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 203124008367 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 203124008368 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 203124008369 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 203124008370 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 203124008371 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 203124008372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124008373 homodimer interface [polypeptide binding]; other site 203124008374 catalytic residue [active] 203124008375 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 203124008376 amidohydrolase; Region: amidohydrolases; TIGR01891 203124008377 metal binding site [ion binding]; metal-binding site 203124008378 dimer interface [polypeptide binding]; other site 203124008379 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 203124008380 TM-ABC transporter signature motif; other site 203124008381 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 203124008382 TM-ABC transporter signature motif; other site 203124008383 Cytochrome P450; Region: p450; cl12078 203124008384 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 203124008385 homodimer interface [polypeptide binding]; other site 203124008386 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 203124008387 active site pocket [active] 203124008388 O-Antigen ligase; Region: Wzy_C; cl04850 203124008389 amidophosphoribosyltransferase; Provisional; Region: PRK07349 203124008390 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 203124008391 active site 203124008392 tetramer interface [polypeptide binding]; other site 203124008393 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 203124008394 Chorismate lyase; Region: Chor_lyase; cl01230 203124008395 HSP90 family protein; Provisional; Region: PRK14083 203124008396 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 203124008397 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 203124008398 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 203124008399 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 203124008400 YGGT family; Region: YGGT; cl00508 203124008401 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 203124008402 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124008403 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124008404 large tegument protein UL36; Provisional; Region: PHA03247 203124008405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124008406 Walker A motif; other site 203124008407 ATP binding site [chemical binding]; other site 203124008408 Walker B motif; other site 203124008409 arginine finger; other site 203124008410 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 203124008411 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124008412 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 203124008413 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 203124008414 RDD family; Region: RDD; cl00746 203124008415 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 203124008416 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 203124008417 RNB domain; Region: RNB; pfam00773 203124008418 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 203124008419 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 203124008420 catalytic residues [active] 203124008421 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 203124008422 DEAD-like helicases superfamily; Region: DEXDc; smart00487 203124008423 ATP binding site [chemical binding]; other site 203124008424 Mg++ binding site [ion binding]; other site 203124008425 motif III; other site 203124008426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203124008427 nucleotide binding region [chemical binding]; other site 203124008428 ATP-binding site [chemical binding]; other site 203124008429 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 203124008430 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 203124008431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 203124008432 FeS/SAM binding site; other site 203124008433 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 203124008434 ligand binding site [chemical binding]; other site 203124008435 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 203124008436 nudix motif; other site 203124008437 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124008438 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124008439 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 203124008440 Precorrin-8X methylmutase; Region: CbiC; pfam02570 203124008441 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 203124008442 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 203124008443 Walker A/P-loop; other site 203124008444 ATP binding site [chemical binding]; other site 203124008445 Q-loop/lid; other site 203124008446 ABC transporter signature motif; other site 203124008447 Walker B; other site 203124008448 D-loop; other site 203124008449 H-loop/switch region; other site 203124008450 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 203124008451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008452 TPR motif; other site 203124008453 binding surface 203124008454 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 203124008455 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 203124008456 nudix motif; other site 203124008457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008458 TPR motif; other site 203124008459 binding surface 203124008460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008461 binding surface 203124008462 TPR motif; other site 203124008463 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 203124008464 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 203124008465 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 203124008466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124008467 S-adenosylmethionine binding site [chemical binding]; other site 203124008468 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124008469 active site 203124008470 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 203124008471 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 203124008472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008473 binding surface 203124008474 TPR motif; other site 203124008475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124008476 FtsH Extracellular; Region: FtsH_ext; pfam06480 203124008477 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 203124008478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124008479 Walker A motif; other site 203124008480 ATP binding site [chemical binding]; other site 203124008481 Walker B motif; other site 203124008482 arginine finger; other site 203124008483 Peptidase family M41; Region: Peptidase_M41; pfam01434 203124008484 homocitrate synthase; Region: LysS_fung_arch; TIGR02146 203124008485 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 203124008486 active site 203124008487 catalytic residues [active] 203124008488 metal binding site [ion binding]; metal-binding site 203124008489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124008490 active site 203124008491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124008492 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 203124008493 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 203124008494 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 203124008495 dimer interface [polypeptide binding]; other site 203124008496 substrate binding site [chemical binding]; other site 203124008497 ATP binding site [chemical binding]; other site 203124008498 cell division protein FtsZ; Validated; Region: PRK09330 203124008499 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 203124008500 nucleotide binding site [chemical binding]; other site 203124008501 SulA interaction site; other site 203124008502 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 203124008503 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 203124008504 Integrase core domain; Region: rve; cl01316 203124008505 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124008506 GTP/Mg2+ binding site [chemical binding]; other site 203124008507 G5 box; other site 203124008508 G1 box; other site 203124008509 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 203124008510 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124008511 structural tetrad; other site 203124008512 FOG: WD40 repeat [General function prediction only]; Region: COG2319 203124008513 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 203124008514 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124008515 structural tetrad; other site 203124008516 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 203124008517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124008518 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that...; Region: ArsC_15kD; cd03033 203124008519 putative catalytic residues [active] 203124008520 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124008521 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124008522 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124008523 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124008524 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124008525 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124008526 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124008527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008528 binding surface 203124008529 TPR motif; other site 203124008530 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124008531 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 203124008532 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 203124008533 hinge region; other site 203124008534 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 203124008535 putative nucleotide binding site [chemical binding]; other site 203124008536 uridine monophosphate binding site [chemical binding]; other site 203124008537 homohexameric interface [polypeptide binding]; other site 203124008538 Arginase family; Region: Arginase; cl00306 203124008539 hydrolase, alpha/beta fold family protein; Region: PLN02824 203124008540 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 203124008541 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 203124008542 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 203124008543 Walker A/P-loop; other site 203124008544 ATP binding site [chemical binding]; other site 203124008545 Q-loop/lid; other site 203124008546 ABC transporter signature motif; other site 203124008547 Walker B; other site 203124008548 D-loop; other site 203124008549 H-loop/switch region; other site 203124008550 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124008551 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 203124008552 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 203124008553 Ligand binding site [chemical binding]; other site 203124008554 Putative Catalytic site [active] 203124008555 DXD motif; other site 203124008556 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 203124008557 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 203124008558 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 203124008559 Predicted domain in sensory proteins (DUF2308); Region: DUF2308; cl01731 203124008560 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124008561 GAF domain; Region: GAF; cl00853 203124008562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124008563 dimer interface [polypeptide binding]; other site 203124008564 phosphorylation site [posttranslational modification] 203124008565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124008566 ATP binding site [chemical binding]; other site 203124008567 Mg2+ binding site [ion binding]; other site 203124008568 G-X-G motif; other site 203124008569 PsaD; Region: PsaD; cl03639 203124008570 anthranilate synthase component I; Provisional; Region: PRK13565 203124008571 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 203124008572 chorismate binding enzyme; Region: Chorismate_bind; cl10555 203124008573 pheophorbide a oxygenase; Region: PLN02518 203124008574 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 203124008575 iron-sulfur cluster [ion binding]; other site 203124008576 [2Fe-2S] cluster binding site [ion binding]; other site 203124008577 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 203124008578 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 203124008579 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 203124008580 Domain of unknown function (DUF74); Region: DUF74; cl00426 203124008581 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008582 binding surface 203124008583 TPR motif; other site 203124008584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008585 binding surface 203124008586 TPR motif; other site 203124008587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008588 binding surface 203124008589 TPR motif; other site 203124008590 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl14636 203124008591 Leucine-rich repeats; other site 203124008592 Substrate binding site [chemical binding]; other site 203124008593 hypothetical protein; Provisional; Region: PLN03150 203124008594 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 203124008595 G1 box; other site 203124008596 GTP/Mg2+ binding site [chemical binding]; other site 203124008597 G2 box; other site 203124008598 Switch I region; other site 203124008599 G3 box; other site 203124008600 Switch II region; other site 203124008601 G5 box; other site 203124008602 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124008603 Active site [active] 203124008604 Protein of unknown function (DUF565); Region: DUF565; pfam04483 203124008605 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 203124008606 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 203124008607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124008608 dimer interface [polypeptide binding]; other site 203124008609 phosphorylation site [posttranslational modification] 203124008610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124008611 ATP binding site [chemical binding]; other site 203124008612 Mg2+ binding site [ion binding]; other site 203124008613 G-X-G motif; other site 203124008614 Response regulator receiver domain; Region: Response_reg; pfam00072 203124008615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124008616 active site 203124008617 phosphorylation site [posttranslational modification] 203124008618 intermolecular recognition site; other site 203124008619 dimerization interface [polypeptide binding]; other site 203124008620 KaiA domain; Region: KaiA; pfam07688 203124008621 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as...; Region: KaiB_like; cd02978 203124008622 tetramer interface [polypeptide binding]; other site 203124008623 dimer interface [polypeptide binding]; other site 203124008624 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 203124008625 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 203124008626 Walker A motif; other site 203124008627 ATP binding site [chemical binding]; other site 203124008628 Walker B motif; other site 203124008629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124008630 ATP binding site [chemical binding]; other site 203124008631 Walker B motif; other site 203124008632 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 203124008633 Predicted permease; Region: DUF318; cl00487 203124008634 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 203124008635 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 203124008636 glycerol kinase; Region: glycerol_kin; TIGR01311 203124008637 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 203124008638 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 203124008639 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 203124008640 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 203124008641 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls...; Region: Pchlide_reductase_B; cd01981 203124008642 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 203124008643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124008644 S-adenosylmethionine binding site [chemical binding]; other site 203124008645 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124008646 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 203124008647 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 203124008648 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 203124008649 active site 203124008650 Acyl transferase domain; Region: Acyl_transf_1; cl08282 203124008651 PKS_DH; Region: PKS_DH; smart00826 203124008652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124008653 S-adenosylmethionine binding site [chemical binding]; other site 203124008654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124008655 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 203124008656 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 203124008657 Enoylreductase; Region: PKS_ER; smart00829 203124008658 NAD(P) binding site [chemical binding]; other site 203124008659 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 203124008660 putative NADP binding site [chemical binding]; other site 203124008661 active site 203124008662 Phosphopantetheine attachment site; Region: PP-binding; cl09936 203124008663 Condensation domain; Region: Condensation; cl09290 203124008664 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 203124008665 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 203124008666 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 203124008667 peptide synthase; Provisional; Region: PRK12316 203124008668 Phosphopantetheine attachment site; Region: PP-binding; cl09936 203124008669 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 203124008670 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 203124008671 active site 203124008672 Acyl transferase domain; Region: Acyl_transf_1; cl08282 203124008673 PKS_DH; Region: PKS_DH; smart00826 203124008674 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 203124008675 putative NADP binding site [chemical binding]; other site 203124008676 active site 203124008677 Phosphopantetheine attachment site; Region: PP-binding; cl09936 203124008678 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 203124008679 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 203124008680 active site 203124008681 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 203124008682 Acyl transferase domain; Region: Acyl_transf_1; cl08282 203124008683 Phosphopantetheine attachment site; Region: PP-binding; cl09936 203124008684 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124008685 Thioesterase domain; Region: Thioesterase; pfam00975 203124008686 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124008687 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 203124008688 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 203124008689 nucleophilic elbow; other site 203124008690 catalytic triad; other site 203124008691 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 203124008692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124008693 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 203124008694 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 203124008695 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 203124008696 active site 203124008697 ATP binding site [chemical binding]; other site 203124008698 haemagglutination activity domain; Region: Haemagg_act; cl05436 203124008699 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 203124008700 CHAT domain; Region: CHAT; cl02083 203124008701 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 203124008702 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 203124008703 Domain of unknown function (DUF1821); Region: DUF1821; pfam08851 203124008704 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 203124008705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124008706 S-adenosylmethionine binding site [chemical binding]; other site 203124008707 glutamine synthetase, type I; Region: GlnA; TIGR00653 203124008708 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 203124008709 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 203124008710 Phycobilisome protein; Region: Phycobilisome; cl08227 203124008711 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 203124008712 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 203124008713 RNA binding surface [nucleotide binding]; other site 203124008714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124008715 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 203124008716 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 203124008717 G1 box; other site 203124008718 GTP/Mg2+ binding site [chemical binding]; other site 203124008719 Switch I region; other site 203124008720 G2 box; other site 203124008721 Switch II region; other site 203124008722 G3 box; other site 203124008723 G4 box; other site 203124008724 G5 box; other site 203124008725 Domain of unknown function (DUF697); Region: DUF697; cl12064 203124008726 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124008727 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 203124008728 Domain of unknown function (DUF697); Region: DUF697; cl12064 203124008729 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 203124008730 putative catalytic residue [active] 203124008731 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 203124008732 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 203124008733 GatB domain; Region: GatB_Yqey; cl11497 203124008734 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 203124008735 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 203124008736 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 203124008737 Hexamer interface [polypeptide binding]; other site 203124008738 Hexagonal pore residue; other site 203124008739 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 203124008740 Hexamer interface [polypeptide binding]; other site 203124008741 Hexagonal pore residue; other site 203124008742 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 203124008743 putative trimer interface [polypeptide binding]; other site 203124008744 putative CoA binding site [chemical binding]; other site 203124008745 Low molecular weight phosphatase family; Region: LMWPc; cl00105 203124008746 Active site [active] 203124008747 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 203124008748 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide...; Region: LbH_gamma_CA; cd00710 203124008749 trimer interface [polypeptide binding]; other site 203124008750 active site 203124008751 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 203124008752 putative multimerization interface [polypeptide binding]; other site 203124008753 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 203124008754 putative multimerization interface [polypeptide binding]; other site 203124008755 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 203124008756 putative multimerization interface [polypeptide binding]; other site 203124008757 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 203124008758 putative multimerization interface [polypeptide binding]; other site 203124008759 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 203124008760 Hexamer/Pentamer interface [polypeptide binding]; other site 203124008761 central pore; other site 203124008762 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 203124008763 Hexamer interface [polypeptide binding]; other site 203124008764 Hexagonal pore residue; other site 203124008765 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 203124008766 Hexamer interface [polypeptide binding]; other site 203124008767 Hexagonal pore residue; other site 203124008768 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 203124008769 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 203124008770 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 203124008771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203124008772 putative substrate translocation pore; other site 203124008773 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 203124008774 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124008775 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124008776 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124008777 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124008778 active site 203124008779 ATP binding site [chemical binding]; other site 203124008780 substrate binding site [chemical binding]; other site 203124008781 activation loop (A-loop); other site 203124008782 Predicted ATPase [General function prediction only]; Region: COG3899 203124008783 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124008784 GAF domain; Region: GAF; cl00853 203124008785 Competence protein; Region: Competence; cl00471 203124008786 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 203124008787 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14949 203124008788 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 203124008789 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 203124008790 dimer interface [polypeptide binding]; other site 203124008791 motif 1; other site 203124008792 active site 203124008793 motif 2; other site 203124008794 motif 3; other site 203124008795 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 203124008796 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 203124008797 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 203124008798 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 203124008799 FOG: WD40 repeat [General function prediction only]; Region: COG2319 203124008800 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124008801 structural tetrad; other site 203124008802 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124008803 structural tetrad; other site 203124008804 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 203124008805 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 203124008806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 203124008807 phosphoglycolate phosphatase; Provisional; Region: PRK01158 203124008808 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 203124008809 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 203124008810 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 203124008811 Beta-lactamase; Region: Beta-lactamase; cl01009 203124008812 exonuclease SbcC; Region: sbcc; TIGR00618 203124008813 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 203124008814 Walker A/P-loop; other site 203124008815 ATP binding site [chemical binding]; other site 203124008816 Q-loop/lid; other site 203124008817 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 203124008818 ABC transporter signature motif; other site 203124008819 Walker B; other site 203124008820 D-loop; other site 203124008821 H-loop/switch region; other site 203124008822 PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cl00011 203124008823 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 203124008824 nucleophilic elbow; other site 203124008825 catalytic triad; other site 203124008826 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124008827 UbiA prenyltransferase family; Region: UbiA; cl00337 203124008828 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 203124008829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124008830 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 203124008831 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 203124008832 Cation transport protein; Region: TrkH; cl10514 203124008833 tocopherol O-methyltransferase; Region: PLN02244 203124008834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124008835 S-adenosylmethionine binding site [chemical binding]; other site 203124008836 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 203124008837 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 203124008838 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 203124008839 anti sigma factor interaction site; other site 203124008840 regulatory phosphorylation site [posttranslational modification]; other site 203124008841 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 203124008842 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 203124008843 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 203124008844 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 203124008845 active site 203124008846 putative substrate binding region [chemical binding]; other site 203124008847 Fatty acid desaturase; Region: FA_desaturase; pfam00487 203124008848 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 203124008849 putative di-iron ligands [ion binding]; other site 203124008850 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 203124008851 dimer interface [polypeptide binding]; other site 203124008852 ADP-ribose binding site [chemical binding]; other site 203124008853 active site 203124008854 nudix motif; other site 203124008855 metal binding site [ion binding]; metal-binding site 203124008856 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 203124008857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008858 binding surface 203124008859 TPR motif; other site 203124008860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008861 binding surface 203124008862 TPR motif; other site 203124008863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008864 binding surface 203124008865 TPR motif; other site 203124008866 CHAT domain; Region: CHAT; cl02083 203124008867 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 203124008868 Protein of unknown function (DUF751); Region: DUF751; pfam05421 203124008869 CpeS-like protein; Region: CpeS; pfam09367 203124008870 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 203124008871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 203124008872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124008873 ATP binding site [chemical binding]; other site 203124008874 Mg2+ binding site [ion binding]; other site 203124008875 G-X-G motif; other site 203124008876 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 203124008877 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 203124008878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 203124008879 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 203124008880 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 203124008881 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 203124008882 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 203124008883 DNA binding residues [nucleotide binding] 203124008884 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 203124008885 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124008886 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124008887 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124008888 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 203124008889 active site 203124008890 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 203124008891 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 203124008892 active site 203124008893 putative substrate binding region [chemical binding]; other site 203124008894 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a...; Region: CBS_pair_M50_like; cd04801 203124008895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124008896 Walker A motif; other site 203124008897 ATP binding site [chemical binding]; other site 203124008898 FOG: WD40 repeat [General function prediction only]; Region: COG2319 203124008899 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 203124008900 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124008901 structural tetrad; other site 203124008902 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124008903 structural tetrad; other site 203124008904 FOG: WD40 repeat [General function prediction only]; Region: COG2319 203124008905 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 203124008906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008907 binding surface 203124008908 TPR motif; other site 203124008909 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 203124008910 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 203124008911 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 203124008912 classical (c) SDRs; Region: SDR_c; cd05233 203124008913 NAD(P) binding site [chemical binding]; other site 203124008914 active site 203124008915 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cl10034 203124008916 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124008917 flavoprotein, HI0933 family; Region: TIGR00275 203124008918 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 203124008919 Rubredoxin; Region: Rubredoxin; pfam00301 203124008920 iron binding site [ion binding]; other site 203124008921 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 203124008922 S-layer homology domain; Region: SLH; pfam00395 203124008923 S-layer homology domain; Region: SLH; pfam00395 203124008924 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124008925 structural tetrad; other site 203124008926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124008927 Walker A motif; other site 203124008928 ATP binding site [chemical binding]; other site 203124008929 FOG: WD40 repeat [General function prediction only]; Region: COG2319 203124008930 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 203124008931 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124008932 structural tetrad; other site 203124008933 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008934 binding surface 203124008935 TPR motif; other site 203124008936 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 203124008937 catalytic motif [active] 203124008938 Catalytic residue [active] 203124008939 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 203124008940 catalytic motif [active] 203124008941 Catalytic residue [active] 203124008942 Calx-beta domain; Region: Calx-beta; cl02522 203124008943 Calx-beta domain; Region: Calx-beta; cl02522 203124008944 Calx-beta domain; Region: Calx-beta; cl02522 203124008945 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 203124008946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008947 TPR motif; other site 203124008948 binding surface 203124008949 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144 203124008950 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 203124008951 cobalamin binding residues [chemical binding]; other site 203124008952 putative BtuC binding residues; other site 203124008953 dimer interface [polypeptide binding]; other site 203124008954 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 203124008955 catalytic residue [active] 203124008956 GUN4-like; Region: GUN4; pfam05419 203124008957 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124008958 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 203124008959 TIGR01777 family protein; Region: yfcH 203124008960 putative NAD(P) binding site [chemical binding]; other site 203124008961 putative active site [active] 203124008962 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 203124008963 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 203124008964 carotene 7,8-desaturase; Region: zeta_caro_desat; TIGR02732 203124008965 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124008966 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 203124008967 putative hydrophobic ligand binding site [chemical binding]; other site 203124008968 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 203124008969 catalytic loop [active] 203124008970 iron binding site [ion binding]; other site 203124008971 cobyric acid synthase; Provisional; Region: PRK00784 203124008972 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124008973 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124008974 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 203124008975 catalytic triad [active] 203124008976 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 203124008977 catalytic triad [active] 203124008978 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 203124008979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 203124008980 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 203124008981 anchoring element; other site 203124008982 dimer interface [polypeptide binding]; other site 203124008983 ATP binding site [chemical binding]; other site 203124008984 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 203124008985 thioester formation/cholesterol transfer; other site 203124008986 protein-splicing catalytic site; other site 203124008987 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl09966 203124008988 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 203124008989 active site 203124008990 putative metal-binding site [ion binding]; other site 203124008991 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 203124008992 IPP transferase; Region: IPPT; cl00403 203124008993 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 203124008994 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 203124008995 active site 203124008996 catalytic residues [active] 203124008997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124008998 binding surface 203124008999 TPR motif; other site 203124009000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009001 binding surface 203124009002 TPR motif; other site 203124009003 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009004 binding surface 203124009005 TPR motif; other site 203124009006 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 203124009007 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 203124009008 transmembrane helices; other site 203124009009 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 203124009010 ligand-binding site [chemical binding]; other site 203124009011 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 203124009012 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 203124009013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124009014 Response regulator receiver domain; Region: Response_reg; pfam00072 203124009015 active site 203124009016 phosphorylation site [posttranslational modification] 203124009017 intermolecular recognition site; other site 203124009018 dimerization interface [polypeptide binding]; other site 203124009019 GAF domain; Region: GAF; cl00853 203124009020 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 203124009021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124009022 S-adenosylmethionine binding site [chemical binding]; other site 203124009023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 203124009024 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 203124009025 translation initiation factor IF-2; Validated; Region: infB; PRK05306 203124009026 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 203124009027 translation initiation factor IF-2; Region: IF-2; TIGR00487 203124009028 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 203124009029 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 203124009030 G1 box; other site 203124009031 putative GEF interaction site [polypeptide binding]; other site 203124009032 GTP/Mg2+ binding site [chemical binding]; other site 203124009033 Switch I region; other site 203124009034 G2 box; other site 203124009035 G3 box; other site 203124009036 Switch II region; other site 203124009037 G4 box; other site 203124009038 G5 box; other site 203124009039 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 203124009040 Translation-initiation factor 2; Region: IF-2; pfam11987 203124009041 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 203124009042 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 203124009043 putative RNA binding cleft [nucleotide binding]; other site 203124009044 transcription elongation factor NusA; Provisional; Region: nusA; PRK12329 203124009045 NusA N-terminal domain; Region: NusA_N; pfam08529 203124009046 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 203124009047 RNA binding site [nucleotide binding]; other site 203124009048 homodimer interface [polypeptide binding]; other site 203124009049 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 203124009050 G-X-X-G motif; other site 203124009051 ribosome maturation protein RimP; Reviewed; Region: PRK00092 203124009052 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 203124009053 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 203124009054 Sm1 motif; other site 203124009055 D3 - B interaction site; other site 203124009056 D1 - D2 interaction site; other site 203124009057 Hfq - Hfq interaction site; other site 203124009058 RNA binding pocket [nucleotide binding]; other site 203124009059 Sm2 motif; other site 203124009060 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 203124009061 Malic enzyme, N-terminal domain; Region: malic; pfam00390 203124009062 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 203124009063 putative NAD(P) binding site [chemical binding]; other site 203124009064 arginine-tRNA ligase; Region: PLN02286 203124009065 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 203124009066 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 203124009067 active site 203124009068 HIGH motif; other site 203124009069 KMSK motif region; other site 203124009070 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 203124009071 tRNA binding surface [nucleotide binding]; other site 203124009072 anticodon binding site; other site 203124009073 Response regulator receiver domain; Region: Response_reg; pfam00072 203124009074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124009075 active site 203124009076 phosphorylation site [posttranslational modification] 203124009077 intermolecular recognition site; other site 203124009078 dimerization interface [polypeptide binding]; other site 203124009079 Glutaminase; Region: Glutaminase; cl00907 203124009080 classical (c) SDRs; Region: SDR_c; cd05233 203124009081 NAD(P) binding site [chemical binding]; other site 203124009082 active site 203124009083 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 203124009084 sensory histidine kinase AtoS; Provisional; Region: PRK11360 203124009085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 203124009086 PAS domain S-box; Region: sensory_box; TIGR00229 203124009087 PAS domain S-box; Region: sensory_box; TIGR00229 203124009088 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 203124009089 PAS domain S-box; Region: sensory_box; TIGR00229 203124009090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 203124009091 putative active site [active] 203124009092 heme pocket [chemical binding]; other site 203124009093 cyclase homology domain; Region: CHD; cd07302 203124009094 nucleotidyl binding site; other site 203124009095 metal binding site [ion binding]; metal-binding site 203124009096 dimer interface [polypeptide binding]; other site 203124009097 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 203124009098 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 203124009099 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 203124009100 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 203124009101 active site 203124009102 Zn binding site [ion binding]; other site 203124009103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009104 binding surface 203124009105 TPR motif; other site 203124009106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009107 binding surface 203124009108 TPR motif; other site 203124009109 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 203124009110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009111 binding surface 203124009112 TPR motif; other site 203124009113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009114 binding surface 203124009115 TPR motif; other site 203124009116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009117 binding surface 203124009118 TPR motif; other site 203124009119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 203124009120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009121 binding surface 203124009122 TPR motif; other site 203124009123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009124 binding surface 203124009125 TPR motif; other site 203124009126 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 203124009127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009128 binding surface 203124009129 TPR motif; other site 203124009130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009131 binding surface 203124009132 TPR motif; other site 203124009133 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 203124009134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009135 binding surface 203124009136 TPR motif; other site 203124009137 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 203124009138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009139 binding surface 203124009140 TPR motif; other site 203124009141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009142 binding surface 203124009143 TPR motif; other site 203124009144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009145 binding surface 203124009146 TPR motif; other site 203124009147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 203124009148 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009149 binding surface 203124009150 TPR motif; other site 203124009151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009152 binding surface 203124009153 TPR motif; other site 203124009154 Protein of function (DUF2518); Region: DUF2518; pfam10726 203124009155 Response regulator receiver domain; Region: Response_reg; pfam00072 203124009156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124009157 active site 203124009158 phosphorylation site [posttranslational modification] 203124009159 intermolecular recognition site; other site 203124009160 dimerization interface [polypeptide binding]; other site 203124009161 cyclase homology domain; Region: CHD; cd07302 203124009162 nucleotidyl binding site; other site 203124009163 metal binding site [ion binding]; metal-binding site 203124009164 dimer interface [polypeptide binding]; other site 203124009165 Response regulator receiver domain; Region: Response_reg; pfam00072 203124009166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124009167 active site 203124009168 phosphorylation site [posttranslational modification] 203124009169 intermolecular recognition site; other site 203124009170 dimerization interface [polypeptide binding]; other site 203124009171 Domain of unknown function DUF20; Region: UPF0118; cl00465 203124009172 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 203124009173 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 203124009174 active site 203124009175 HIGH motif; other site 203124009176 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 203124009177 KMSKS motif; other site 203124009178 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 203124009179 tRNA binding surface [nucleotide binding]; other site 203124009180 anticodon binding site; other site 203124009181 Peptidase family M48; Region: Peptidase_M48; cl12018 203124009182 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 203124009183 RNA/DNA binding site [nucleotide binding]; other site 203124009184 RRM dimerization site [polypeptide binding]; other site 203124009185 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 203124009186 active site lid residues [active] 203124009187 substrate binding pocket [chemical binding]; other site 203124009188 catalytic residues [active] 203124009189 substrate-Mg2+ binding site; other site 203124009190 aspartate-rich region 1; other site 203124009191 aspartate-rich region 2; other site 203124009192 Uncharacterized conserved protein [Function unknown]; Region: COG3349 203124009193 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124009194 molecular chaperone DnaK; Provisional; Region: PRK13410 203124009195 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 203124009196 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 203124009197 HSP70 interaction site [polypeptide binding]; other site 203124009198 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 203124009199 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 203124009200 Indoleamine 2,3-dioxygenase; Region: IDO; pfam01231 203124009201 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH...; Region: GST_N_etherase_LigE; cd03038 203124009202 Glutaredoxin, GrxB family; Region: GRXB; TIGR02182 203124009203 putative C-terminal domain interface [polypeptide binding]; other site 203124009204 putative GSH binding site (G-site) [chemical binding]; other site 203124009205 putative dimer interface [polypeptide binding]; other site 203124009206 GST_C family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH...; Region: GST_C_etherase_LigE; cd03202 203124009207 putative dimer interface [polypeptide binding]; other site 203124009208 putative lignin/substrate binding pocket (H-site); other site 203124009209 putative N-terminal domain interface [polypeptide binding]; other site 203124009210 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124009211 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124009212 KGK domain; Region: KGK; pfam08872 203124009213 KGK domain; Region: KGK; pfam08872 203124009214 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 203124009215 active site 203124009216 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 203124009217 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 203124009218 active site 203124009219 dimer interface [polypeptide binding]; other site 203124009220 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 203124009221 dimer interface [polypeptide binding]; other site 203124009222 active site 203124009223 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 203124009224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124009225 active site 203124009226 phosphorylation site [posttranslational modification] 203124009227 intermolecular recognition site; other site 203124009228 dimerization interface [polypeptide binding]; other site 203124009229 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 203124009230 DNA binding residues [nucleotide binding] 203124009231 dimerization interface [polypeptide binding]; other site 203124009232 Low molecular weight phosphatase family; Region: LMWPc; cd00115 203124009233 Active site [active] 203124009234 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 203124009235 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 203124009236 FAD binding domain; Region: FAD_binding_4; pfam01565 203124009237 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 203124009238 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 203124009239 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 203124009240 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 203124009241 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 203124009242 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 203124009243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124009244 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 203124009245 thiamine monophosphate kinase; Provisional; Region: PRK05731 203124009246 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 203124009247 ATP binding site [chemical binding]; other site 203124009248 dimerization interface [polypeptide binding]; other site 203124009249 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 203124009250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124009251 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 203124009252 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 203124009253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124009254 active site 203124009255 Bacterial SH3 domain; Region: SH3_3; cl02551 203124009256 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 203124009257 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 203124009258 active site 203124009259 metal binding site [ion binding]; metal-binding site 203124009260 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124009261 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 203124009262 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 203124009263 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 203124009264 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 203124009265 catalytic residue [active] 203124009266 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 203124009267 adaptive-response sensory kinase; Validated; Region: PRK09303 203124009268 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as...; Region: KaiB_like; cd02978 203124009269 tetramer interface [polypeptide binding]; other site 203124009270 dimer interface [polypeptide binding]; other site 203124009271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124009272 ATP binding site [chemical binding]; other site 203124009273 Mg2+ binding site [ion binding]; other site 203124009274 G-X-G motif; other site 203124009275 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 203124009276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124009277 Walker A motif; other site 203124009278 ATP binding site [chemical binding]; other site 203124009279 Walker B motif; other site 203124009280 arginine finger; other site 203124009281 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124009282 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 203124009283 active site 203124009284 8-oxo-dGMP binding site [chemical binding]; other site 203124009285 nudix motif; other site 203124009286 metal binding site [ion binding]; metal-binding site 203124009287 Protein of unknown function (DUF760); Region: DUF760; pfam05542 203124009288 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 203124009289 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 203124009290 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 203124009291 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 203124009292 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 203124009293 DNA binding residues [nucleotide binding] 203124009294 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 203124009295 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124009296 active site 203124009297 ATP binding site [chemical binding]; other site 203124009298 substrate binding site [chemical binding]; other site 203124009299 activation loop (A-loop); other site 203124009300 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124009301 structural tetrad; other site 203124009302 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 203124009303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124009304 Walker A motif; other site 203124009305 ATP binding site [chemical binding]; other site 203124009306 Walker B motif; other site 203124009307 tellurite resistance protein terB; Region: terB; cd07176 203124009308 putative metal binding site [ion binding]; other site 203124009309 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 203124009310 active site 203124009311 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 203124009312 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 203124009313 O-succinylbenzoate synthase; Provisional; Region: PRK02714 203124009314 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway...; Region: OSBS; cd03320 203124009315 active site 203124009316 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 203124009317 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124009318 SelR domain; Region: SelR; cl00369 203124009319 UbiA prenyltransferase family; Region: UbiA; cl00337 203124009320 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 203124009321 chorismate binding enzyme; Region: Chorismate_bind; cl10555 203124009322 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 203124009323 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 203124009324 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 203124009325 dimer interface [polypeptide binding]; other site 203124009326 tetramer interface [polypeptide binding]; other site 203124009327 PYR/PP interface [polypeptide binding]; other site 203124009328 TPP binding site [chemical binding]; other site 203124009329 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 203124009330 TPP-binding site; other site 203124009331 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 203124009332 GSH binding site [chemical binding]; other site 203124009333 catalytic residues [active] 203124009334 phage shock protein PspA; Provisional; Region: PRK10698 203124009335 phage shock protein A; Region: phageshock_pspA; TIGR02977 203124009336 phage shock protein PspA; Provisional; Region: PRK10698 203124009337 PspA/IM30 family; Region: PspA_IM30; pfam04012 203124009338 phage shock protein PspA; Provisional; Region: PRK10698 203124009339 PspA/IM30 family; Region: PspA_IM30; pfam04012 203124009340 Protein of unknown function (DUF721); Region: DUF721; cl02324 203124009341 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 203124009342 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 203124009343 substrate binding site [chemical binding]; other site 203124009344 oxyanion hole (OAH) forming residues; other site 203124009345 trimer interface [polypeptide binding]; other site 203124009346 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 203124009347 nucleoside/Zn binding site; other site 203124009348 dimer interface [polypeptide binding]; other site 203124009349 catalytic motif [active] 203124009350 FAD binding domain; Region: FAD_binding_4; pfam01565 203124009351 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 203124009352 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 203124009353 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 203124009354 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 203124009355 Ligand binding site [chemical binding]; other site 203124009356 Putative Catalytic site [active] 203124009357 DXD motif; other site 203124009358 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 203124009359 RDD family; Region: RDD; cl00746 203124009360 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 203124009361 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009362 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009363 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009364 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009365 hypothetical protein; Provisional; Region: PRK08185 203124009366 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 203124009367 intersubunit interface [polypeptide binding]; other site 203124009368 active site 203124009369 zinc binding site [ion binding]; other site 203124009370 Na+ binding site [ion binding]; other site 203124009371 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 203124009372 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 203124009373 putative active site [active] 203124009374 putative metal binding site [ion binding]; other site 203124009375 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 203124009376 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 203124009377 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 203124009378 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 203124009379 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 203124009380 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 203124009381 CpeS-like protein; Region: CpeS; pfam09367 203124009382 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 203124009383 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 203124009384 Walker A/P-loop; other site 203124009385 ATP binding site [chemical binding]; other site 203124009386 Q-loop/lid; other site 203124009387 ABC transporter signature motif; other site 203124009388 Walker B; other site 203124009389 D-loop; other site 203124009390 H-loop/switch region; other site 203124009391 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 203124009392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124009393 dimer interface [polypeptide binding]; other site 203124009394 conserved gate region; other site 203124009395 putative PBP binding loops; other site 203124009396 ABC-ATPase subunit interface; other site 203124009397 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124009398 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 203124009399 CpeS-like protein; Region: CpeS; pfam09367 203124009400 secreted effector protein PipB2; Provisional; Region: PRK15196 203124009401 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009402 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009403 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009404 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009405 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 203124009406 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 203124009407 nucleotide binding site/active site [active] 203124009408 HIT family signature motif; other site 203124009409 catalytic residue [active] 203124009410 tellurium resistance terB-like protein; Region: terB_like; cd07177 203124009411 metal binding site [ion binding]; metal-binding site 203124009412 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 203124009413 GTPase CgtA; Reviewed; Region: obgE; PRK12299 203124009414 GTP1/OBG; Region: GTP1_OBG; pfam01018 203124009415 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 203124009416 G1 box; other site 203124009417 GTP/Mg2+ binding site [chemical binding]; other site 203124009418 Switch I region; other site 203124009419 G2 box; other site 203124009420 G3 box; other site 203124009421 Switch II region; other site 203124009422 G4 box; other site 203124009423 G5 box; other site 203124009424 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 203124009425 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 203124009426 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 203124009427 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 203124009428 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 203124009429 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 203124009430 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124009431 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124009432 active site 203124009433 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124009434 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 203124009435 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 203124009436 active site 203124009437 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 203124009438 heat shock protein 90; Provisional; Region: PRK05218 203124009439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 203124009440 NifT/FixU protein; Region: NifT; cl02351 203124009441 NifZ domain; Region: NifZ; pfam04319 203124009442 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 203124009443 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 203124009444 serine O-acetyltransferase; Region: cysE; TIGR01172 203124009445 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 203124009446 trimer interface [polypeptide binding]; other site 203124009447 active site 203124009448 substrate binding site [chemical binding]; other site 203124009449 CoA binding site [chemical binding]; other site 203124009450 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 203124009451 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 203124009452 FeS/SAM binding site; other site 203124009453 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 203124009454 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 203124009455 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 203124009456 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 203124009457 catalytic residue [active] 203124009458 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 203124009459 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 203124009460 trimerization site [polypeptide binding]; other site 203124009461 active site 203124009462 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 203124009463 NifU-like domain; Region: NifU; cl00484 203124009464 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 203124009465 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; Region: Fer4_NifH; pfam00142 203124009466 Nucleotide-binding sites [chemical binding]; other site 203124009467 Walker A motif; other site 203124009468 Switch I region of nucleotide binding site; other site 203124009469 Fe4S4 binding sites [ion binding]; other site 203124009470 Switch II region of nucleotide binding site; other site 203124009471 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 203124009472 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 203124009473 MoFe protein alpha/beta subunit interactions; other site 203124009474 Alpha subunit P cluster binding residues; other site 203124009475 FeMoco binding residues [chemical binding]; other site 203124009476 MoFe protein alpha subunit/Fe protein contacts; other site 203124009477 MoFe protein dimer/ dimer interactions; other site 203124009478 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 203124009479 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 203124009480 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems. Mo-...; Region: Nitrogenase_MoFe_beta; cd01974 203124009481 MoFe protein beta/alpha subunit interactions; other site 203124009482 Beta subunit P cluster binding residues; other site 203124009483 MoFe protein beta subunit/Fe protein contacts; other site 203124009484 MoFe protein dimer/ dimer interactions; other site 203124009485 bifunctional nitrogenase molybdenum-cofactor biosynthesis protein NifE/NifN; Provisional; Region: PRK14477 203124009486 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent...; Region: Oxidoreductase_nitrogenase; cl02775 203124009487 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in...; Region: Nitrogenase_NifN_1; cd01966 203124009488 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 203124009489 Protein of unknown function, DUF269; Region: DUF269; cl03973 203124009490 Nitrogen fixation protein NifW; Region: NifW; cl03935 203124009491 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 203124009492 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 203124009493 ATP binding site [chemical binding]; other site 203124009494 substrate interface [chemical binding]; other site 203124009495 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 203124009496 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 203124009497 catalytic loop [active] 203124009498 iron binding site [ion binding]; other site 203124009499 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124009500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124009501 dimer interface [polypeptide binding]; other site 203124009502 conserved gate region; other site 203124009503 putative PBP binding loops; other site 203124009504 ABC-ATPase subunit interface; other site 203124009505 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124009506 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 203124009507 Walker A/P-loop; other site 203124009508 ATP binding site [chemical binding]; other site 203124009509 Q-loop/lid; other site 203124009510 ABC transporter signature motif; other site 203124009511 Walker B; other site 203124009512 D-loop; other site 203124009513 H-loop/switch region; other site 203124009514 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 203124009515 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 203124009516 putative active site [active] 203124009517 putative metal binding site [ion binding]; other site 203124009518 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 203124009519 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 203124009520 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 203124009521 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 203124009522 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 203124009523 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124009524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 203124009525 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 203124009526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124009527 dimer interface [polypeptide binding]; other site 203124009528 phosphorylation site [posttranslational modification] 203124009529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124009530 ATP binding site [chemical binding]; other site 203124009531 Mg2+ binding site [ion binding]; other site 203124009532 G-X-G motif; other site 203124009533 Response regulator receiver domain; Region: Response_reg; pfam00072 203124009534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124009535 active site 203124009536 phosphorylation site [posttranslational modification] 203124009537 intermolecular recognition site; other site 203124009538 dimerization interface [polypeptide binding]; other site 203124009539 Response regulator receiver domain; Region: Response_reg; pfam00072 203124009540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124009541 active site 203124009542 phosphorylation site [posttranslational modification] 203124009543 intermolecular recognition site; other site 203124009544 dimerization interface [polypeptide binding]; other site 203124009545 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 203124009546 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124009547 dimer interface [polypeptide binding]; other site 203124009548 phosphorylation site [posttranslational modification] 203124009549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124009550 ATP binding site [chemical binding]; other site 203124009551 Mg2+ binding site [ion binding]; other site 203124009552 G-X-G motif; other site 203124009553 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 203124009554 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 203124009555 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124009556 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 203124009557 Walker A/P-loop; other site 203124009558 ATP binding site [chemical binding]; other site 203124009559 Q-loop/lid; other site 203124009560 ABC transporter signature motif; other site 203124009561 Walker B; other site 203124009562 D-loop; other site 203124009563 H-loop/switch region; other site 203124009564 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 203124009565 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124009566 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 203124009567 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124009568 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 203124009569 metal binding site [ion binding]; metal-binding site 203124009570 Beta-lactamase; Region: Beta-lactamase; cl01009 203124009571 Beta-lactamase; Region: Beta-lactamase; cl01009 203124009572 adenylosuccinate lyase; Provisional; Region: PRK07380 203124009573 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 203124009574 tetramer interface [polypeptide binding]; other site 203124009575 active site 203124009576 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 203124009577 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 203124009578 nudix motif; other site 203124009579 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 203124009580 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 203124009581 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 203124009582 homodimer interface [polypeptide binding]; other site 203124009583 NADP binding site [chemical binding]; other site 203124009584 substrate binding site [chemical binding]; other site 203124009585 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 203124009586 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 203124009587 substrate binding pocket [chemical binding]; other site 203124009588 chain length determination region; other site 203124009589 substrate-Mg2+ binding site; other site 203124009590 catalytic residues [active] 203124009591 aspartate-rich region 1; other site 203124009592 active site lid residues [active] 203124009593 aspartate-rich region 2; other site 203124009594 Divergent PAP2 family; Region: DUF212; cl00855 203124009595 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 203124009596 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 203124009597 active site 203124009598 hydrophilic channel; other site 203124009599 dimerization interface [polypeptide binding]; other site 203124009600 catalytic residues [active] 203124009601 active site lid [active] 203124009602 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 203124009603 catalytic residue [active] 203124009604 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 203124009605 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 203124009606 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 203124009607 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 203124009608 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 203124009609 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 203124009610 dimer interface [polypeptide binding]; other site 203124009611 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 203124009612 active site 203124009613 Fe binding site [ion binding]; other site 203124009614 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 203124009615 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 203124009616 DNA gyrase subunit A; Validated; Region: PRK05560 203124009617 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 203124009618 CAP-like domain; other site 203124009619 Active site [active] 203124009620 primary dimer interface [polypeptide binding]; other site 203124009621 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 203124009622 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 203124009623 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 203124009624 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 203124009625 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 203124009626 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 203124009627 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 203124009628 putative active site [active] 203124009629 catalytic triad [active] 203124009630 putative dimer interface [polypeptide binding]; other site 203124009631 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 203124009632 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124009633 Cache domain; Region: Cache_1; pfam02743 203124009634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 203124009635 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 203124009636 dimerization interface [polypeptide binding]; other site 203124009637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124009638 dimer interface [polypeptide binding]; other site 203124009639 phosphorylation site [posttranslational modification] 203124009640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124009641 ATP binding site [chemical binding]; other site 203124009642 Mg2+ binding site [ion binding]; other site 203124009643 G-X-G motif; other site 203124009644 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 203124009645 DHH family; Region: DHH; pfam01368 203124009646 DHHA1 domain; Region: DHHA1; pfam02272 203124009647 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 203124009648 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124009649 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124009650 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124009651 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 203124009652 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124009653 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124009654 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124009655 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 203124009656 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 203124009657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124009658 S-adenosylmethionine binding site [chemical binding]; other site 203124009659 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 203124009660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124009661 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 203124009662 putative L-serine binding site [chemical binding]; other site 203124009663 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 203124009664 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 203124009665 RNA binding surface [nucleotide binding]; other site 203124009666 amidase; Provisional; Region: PRK09201 203124009667 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 203124009668 Ion channel; Region: Ion_trans_2; cl11596 203124009669 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 203124009670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124009671 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 203124009672 glutathione synthetase; Provisional; Region: PRK05246 203124009673 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 203124009674 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 203124009675 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 203124009676 GSH binding site [chemical binding]; other site 203124009677 catalytic residues [active] 203124009678 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 203124009679 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 203124009680 G1 box; other site 203124009681 GTP/Mg2+ binding site [chemical binding]; other site 203124009682 Switch I region; other site 203124009683 G2 box; other site 203124009684 G3 box; other site 203124009685 Switch II region; other site 203124009686 G4 box; other site 203124009687 G5 box; other site 203124009688 phosphoenolpyruvate synthase; Validated; Region: PRK06464 203124009689 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 203124009690 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 203124009691 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 203124009692 AIPR protein; Region: AIPR; pfam10592 203124009693 NC domain; Region: NC; pfam04970 203124009694 phage shock protein PspA; Provisional; Region: PRK10698 203124009695 transferase, transferring glycosyl groups; Region: PLN02939 203124009696 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 203124009697 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 203124009698 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 203124009699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124009700 binding surface 203124009701 TPR motif; other site 203124009702 CHAT domain; Region: CHAT; cl02083 203124009703 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 203124009704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 203124009705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 203124009706 PAS fold; Region: PAS_4; pfam08448 203124009707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124009708 dimer interface [polypeptide binding]; other site 203124009709 phosphorylation site [posttranslational modification] 203124009710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124009711 ATP binding site [chemical binding]; other site 203124009712 Mg2+ binding site [ion binding]; other site 203124009713 G-X-G motif; other site 203124009714 Response regulator receiver domain; Region: Response_reg; pfam00072 203124009715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124009716 active site 203124009717 phosphorylation site [posttranslational modification] 203124009718 intermolecular recognition site; other site 203124009719 dimerization interface [polypeptide binding]; other site 203124009720 Response regulator receiver domain; Region: Response_reg; pfam00072 203124009721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124009722 active site 203124009723 phosphorylation site [posttranslational modification] 203124009724 intermolecular recognition site; other site 203124009725 dimerization interface [polypeptide binding]; other site 203124009726 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 203124009727 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 203124009728 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 203124009729 putative binding surface; other site 203124009730 active site 203124009731 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 203124009732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 203124009733 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 203124009734 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 203124009735 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 203124009736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124009737 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 203124009738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124009739 active site 203124009740 phosphorylation site [posttranslational modification] 203124009741 intermolecular recognition site; other site 203124009742 dimerization interface [polypeptide binding]; other site 203124009743 CheB methylesterase; Region: CheB_methylest; pfam01339 203124009744 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 203124009745 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 203124009746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124009747 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 203124009748 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 203124009749 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 203124009750 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 203124009751 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 203124009752 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 203124009753 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 203124009754 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 203124009755 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 203124009756 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 203124009757 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 203124009758 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 203124009759 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 203124009760 P-loop; other site 203124009761 Magnesium ion binding site [ion binding]; other site 203124009762 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124009763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124009764 Response regulator receiver domain; Region: Response_reg; pfam00072 203124009765 active site 203124009766 phosphorylation site [posttranslational modification] 203124009767 intermolecular recognition site; other site 203124009768 dimerization interface [polypeptide binding]; other site 203124009769 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 203124009770 metal binding site [ion binding]; metal-binding site 203124009771 active site 203124009772 I-site; other site 203124009773 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 203124009774 UvrD/REP helicase; Region: UvrD-helicase; cl14126 203124009775 UvrD/REP helicase; Region: UvrD-helicase; cl14126 203124009776 UvrD/REP helicase; Region: UvrD-helicase; cl14126 203124009777 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 203124009778 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 203124009779 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 203124009780 putative active site [active] 203124009781 catalytic site [active] 203124009782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124009783 ATP binding site [chemical binding]; other site 203124009784 putative Mg++ binding site [ion binding]; other site 203124009785 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 203124009786 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203124009787 nucleotide binding region [chemical binding]; other site 203124009788 ATP-binding site [chemical binding]; other site 203124009789 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 203124009790 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 203124009791 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 203124009792 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 203124009793 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 203124009794 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 203124009795 stage V sporulation protein K; Region: spore_V_K; TIGR02881 203124009796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124009797 Walker A motif; other site 203124009798 ATP binding site [chemical binding]; other site 203124009799 Walker B motif; other site 203124009800 arginine finger; other site 203124009801 stage V sporulation protein K; Region: spore_V_K; TIGR02881 203124009802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124009803 Walker A motif; other site 203124009804 ATP binding site [chemical binding]; other site 203124009805 Walker B motif; other site 203124009806 arginine finger; other site 203124009807 Protein of unknown function DUF262; Region: DUF262; cl14890 203124009808 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 203124009809 TIR domain; Region: TIR; cl02060 203124009810 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 203124009811 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124009812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124009813 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124009814 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 203124009815 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 203124009816 tetramer interface [polypeptide binding]; other site 203124009817 active site 203124009818 Mg2+/Mn2+ binding site [ion binding]; other site 203124009819 Integrase core domain; Region: rve; cl01316 203124009820 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 203124009821 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 203124009822 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 203124009823 Uncharacterised protein family (UPF0175); Region: UPF0175; cl01085 203124009824 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 203124009825 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 203124009826 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 203124009827 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124009828 ATP binding site [chemical binding]; other site 203124009829 putative Mg++ binding site [ion binding]; other site 203124009830 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203124009831 nucleotide binding region [chemical binding]; other site 203124009832 ATP-binding site [chemical binding]; other site 203124009833 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 203124009834 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 203124009835 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 203124009836 NAD binding site [chemical binding]; other site 203124009837 homodimer interface [polypeptide binding]; other site 203124009838 active site 203124009839 substrate binding site [chemical binding]; other site 203124009840 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 203124009841 dimer interface [polypeptide binding]; other site 203124009842 [2Fe-2S] cluster binding site [ion binding]; other site 203124009843 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 203124009844 Ferritin-like domain; Region: Ferritin; pfam00210 203124009845 dimerization interface [polypeptide binding]; other site 203124009846 DPS ferroxidase diiron center [ion binding]; other site 203124009847 ion pore; other site 203124009848 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 203124009849 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 203124009850 active site residue [active] 203124009851 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 203124009852 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 203124009853 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009854 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009855 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009856 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009857 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 203124009858 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 203124009859 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 203124009860 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 203124009861 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124009862 Predicted domain in sensory proteins (DUF2308); Region: DUF2308; cl01731 203124009863 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 203124009864 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 203124009865 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124009866 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124009867 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 203124009868 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 203124009869 active site 203124009870 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124009871 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124009872 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124009873 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124009874 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124009875 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124009876 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 203124009877 intersubunit interface [polypeptide binding]; other site 203124009878 active site 203124009879 Zn2+ binding site [ion binding]; other site 203124009880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124009881 MoxR-like ATPases [General function prediction only]; Region: COG0714 203124009882 Walker A motif; other site 203124009883 ATP binding site [chemical binding]; other site 203124009884 Walker B motif; other site 203124009885 Peptidase S46; Region: Peptidase_S46; pfam10459 203124009886 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 203124009887 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 203124009888 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 203124009889 NAD(P) binding site [chemical binding]; other site 203124009890 ferrochelatase; Reviewed; Region: hemH; PRK00035 203124009891 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 203124009892 C-terminal domain interface [polypeptide binding]; other site 203124009893 active site 203124009894 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 203124009895 active site 203124009896 N-terminal domain interface [polypeptide binding]; other site 203124009897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124009898 S-adenosylmethionine binding site [chemical binding]; other site 203124009899 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 203124009900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124009901 opcA protein; Region: OpcA; TIGR00534 203124009902 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 203124009903 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 203124009904 Transposase [DNA replication, recombination, and repair]; Region: COG5421 203124009905 Uncharacterized conserved protein [Function unknown]; Region: COG1432 203124009906 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 203124009907 putative metal binding site [ion binding]; other site 203124009908 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 203124009909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124009910 active site 203124009911 phosphorylation site [posttranslational modification] 203124009912 intermolecular recognition site; other site 203124009913 dimerization interface [polypeptide binding]; other site 203124009914 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 203124009915 DNA binding residues [nucleotide binding] 203124009916 dimerization interface [polypeptide binding]; other site 203124009917 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 203124009918 oligomerisation interface [polypeptide binding]; other site 203124009919 mobile loop; other site 203124009920 roof hairpin; other site 203124009921 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 203124009922 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 203124009923 ring oligomerisation interface [polypeptide binding]; other site 203124009924 ATP/Mg binding site [chemical binding]; other site 203124009925 stacking interactions; other site 203124009926 hinge regions; other site 203124009927 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 203124009928 Hexamer interface [polypeptide binding]; other site 203124009929 Hexagonal pore residue; other site 203124009930 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 203124009931 Hexamer interface [polypeptide binding]; other site 203124009932 Hexagonal pore residue; other site 203124009933 hypothetical protein; Provisional; Region: PRK07394 203124009934 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 203124009935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 203124009936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 203124009937 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 203124009938 dimerization interface [polypeptide binding]; other site 203124009939 ketol-acid reductoisomerase; Provisional; Region: PRK05479 203124009940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124009941 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 203124009942 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009943 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009944 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009945 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 203124009946 NADPH bind site [chemical binding]; other site 203124009947 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 203124009948 putative FMN binding site [chemical binding]; other site 203124009949 NADPH bind site [chemical binding]; other site 203124009950 Predicted kinase [General function prediction only]; Region: COG0645 203124009951 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124009952 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 203124009953 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 203124009954 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 203124009955 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 203124009956 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 203124009957 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124009958 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 203124009959 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 203124009960 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 203124009961 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 203124009962 hydrophobic ligand binding site; other site 203124009963 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 203124009964 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 203124009965 MoaE interaction surface [polypeptide binding]; other site 203124009966 MoeB interaction surface [polypeptide binding]; other site 203124009967 thiocarboxylated glycine; other site 203124009968 threonine synthase; Validated; Region: PRK07591 203124009969 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 203124009970 homodimer interface [polypeptide binding]; other site 203124009971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124009972 catalytic residue [active] 203124009973 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 203124009974 MoaE interaction surface [polypeptide binding]; other site 203124009975 MoeB interaction surface [polypeptide binding]; other site 203124009976 thiocarboxylated glycine; other site 203124009977 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 203124009978 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The...; Region: Peptidase_C39_like; cl00296 203124009979 putative active site [active] 203124009980 Protein kinase domain; Region: Pkinase; pfam00069 203124009981 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124009982 active site 203124009983 ATP binding site [chemical binding]; other site 203124009984 substrate binding site [chemical binding]; other site 203124009985 activation loop (A-loop); other site 203124009986 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124009987 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124009988 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 203124009989 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 203124009990 dimerization interface [polypeptide binding]; other site 203124009991 active site 203124009992 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 203124009993 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 203124009994 putative DNA binding site [nucleotide binding]; other site 203124009995 putative Zn2+ binding site [ion binding]; other site 203124009996 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 203124009997 putative ABC transporter; Region: ycf24; CHL00085 203124009998 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 203124009999 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 203124010000 Walker A/P-loop; other site 203124010001 ATP binding site [chemical binding]; other site 203124010002 Q-loop/lid; other site 203124010003 ABC transporter signature motif; other site 203124010004 Walker B; other site 203124010005 D-loop; other site 203124010006 H-loop/switch region; other site 203124010007 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 203124010008 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 203124010009 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 203124010010 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 203124010011 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 203124010012 catalytic residue [active] 203124010013 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 203124010014 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010015 binding surface 203124010016 TPR motif; other site 203124010017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010018 binding surface 203124010019 TPR motif; other site 203124010020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010021 binding surface 203124010022 TPR motif; other site 203124010023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010024 binding surface 203124010025 TPR motif; other site 203124010026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010027 TPR motif; other site 203124010028 binding surface 203124010029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010030 TPR motif; other site 203124010031 binding surface 203124010032 CHAT domain; Region: CHAT; cl02083 203124010033 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 203124010034 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 203124010035 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 203124010036 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 203124010037 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 203124010038 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 203124010039 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 203124010040 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 203124010041 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 203124010042 MoaE homodimer interface [polypeptide binding]; other site 203124010043 MoaD interaction [polypeptide binding]; other site 203124010044 active site residues [active] 203124010045 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 203124010046 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 203124010047 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 203124010048 DNA binding residues [nucleotide binding] 203124010049 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 203124010050 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 203124010051 putative active site pocket [active] 203124010052 dimerization interface [polypeptide binding]; other site 203124010053 putative catalytic residue [active] 203124010054 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 203124010055 motif I; other site 203124010056 motif II; other site 203124010057 YceG-like family; Region: YceG; pfam02618 203124010058 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 203124010059 dimerization interface [polypeptide binding]; other site 203124010060 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 203124010061 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 203124010062 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 203124010063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203124010064 Coenzyme A binding pocket [chemical binding]; other site 203124010065 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 203124010066 Uncharacterized conserved protein [Function unknown]; Region: COG2006 203124010067 Domain of unknown function (DUF362); Region: DUF362; pfam04015 203124010068 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 203124010069 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 203124010070 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 203124010071 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 203124010072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124010073 S-adenosylmethionine binding site [chemical binding]; other site 203124010074 ubiquitin-activating enzyme E1; Region: Ube1; TIGR01408 203124010075 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 203124010076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 203124010077 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 203124010078 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 203124010079 Peptidase S8 family domain, uncharacterized subfamily 10; Region: Peptidases_S8_10; cd07494 203124010080 active site 203124010081 catalytic triad [active] 203124010082 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124010083 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 203124010084 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 203124010085 ligand binding site [chemical binding]; other site 203124010086 oligomer interface [polypeptide binding]; other site 203124010087 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 203124010088 dimer interface [polypeptide binding]; other site 203124010089 N-terminal domain interface [polypeptide binding]; other site 203124010090 sulfate 1 binding site; other site 203124010091 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124010092 chaperone protein DnaJ; Provisional; Region: PRK14299 203124010093 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 203124010094 HSP70 interaction site [polypeptide binding]; other site 203124010095 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 203124010096 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 203124010097 Protein of unknown function (DUF732); Region: DUF732; pfam05305 203124010098 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 203124010099 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 203124010100 Walker A/P-loop; other site 203124010101 ATP binding site [chemical binding]; other site 203124010102 Q-loop/lid; other site 203124010103 ABC transporter signature motif; other site 203124010104 Walker B; other site 203124010105 D-loop; other site 203124010106 H-loop/switch region; other site 203124010107 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 203124010108 putative active site [active] 203124010109 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 203124010110 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 203124010111 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124010112 Walker A/P-loop; other site 203124010113 ATP binding site [chemical binding]; other site 203124010114 Q-loop/lid; other site 203124010115 ABC transporter signature motif; other site 203124010116 Walker B; other site 203124010117 D-loop; other site 203124010118 H-loop/switch region; other site 203124010119 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 203124010120 isocitrate dehydrogenase; Validated; Region: PRK06451 203124010121 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 203124010122 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 203124010123 putative hydrophobic ligand binding site [chemical binding]; other site 203124010124 protein interface [polypeptide binding]; other site 203124010125 gate; other site 203124010126 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 203124010127 multimerization interface [polypeptide binding]; other site 203124010128 RbcX protein; Region: RcbX; pfam02341 203124010129 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 203124010130 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 203124010131 homodimer interface [polypeptide binding]; other site 203124010132 active site 203124010133 heterodimer interface [polypeptide binding]; other site 203124010134 catalytic residue [active] 203124010135 metal binding site [ion binding]; metal-binding site 203124010136 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124010137 active site 203124010138 ATP binding site [chemical binding]; other site 203124010139 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124010140 substrate binding site [chemical binding]; other site 203124010141 activation loop (A-loop); other site 203124010142 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 203124010143 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124010144 ATP binding site [chemical binding]; other site 203124010145 putative Mg++ binding site [ion binding]; other site 203124010146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203124010147 nucleotide binding region [chemical binding]; other site 203124010148 ATP-binding site [chemical binding]; other site 203124010149 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124010150 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124010151 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 203124010152 protein binding site [polypeptide binding]; other site 203124010153 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 203124010154 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 203124010155 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 203124010156 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 203124010157 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 203124010158 oligomerization interface [polypeptide binding]; other site 203124010159 active site 203124010160 metal binding site [ion binding]; metal-binding site 203124010161 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 203124010162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203124010163 Coenzyme A binding pocket [chemical binding]; other site 203124010164 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 203124010165 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 203124010166 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 203124010167 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 203124010168 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 203124010169 DNA binding residues [nucleotide binding] 203124010170 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 203124010171 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 203124010172 putative active site [active] 203124010173 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_C; cd03414 203124010174 putative active site [active] 203124010175 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 203124010176 Beta-lactamase; Region: Beta-lactamase; cl01009 203124010177 PBP4 family; Region: PBP4; TIGR00666 203124010178 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 203124010179 phosphopeptide binding site; other site 203124010180 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 203124010181 phosphopeptide binding site; other site 203124010182 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with...; Region: ABCG_EPDR; cd03213 203124010183 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 203124010184 Walker A/P-loop; other site 203124010185 ATP binding site [chemical binding]; other site 203124010186 Q-loop/lid; other site 203124010187 ABC transporter signature motif; other site 203124010188 Walker B; other site 203124010189 D-loop; other site 203124010190 H-loop/switch region; other site 203124010191 ABC-2 type transporter; Region: ABC2_membrane; cl11417 203124010192 EVE domain; Region: EVE; cl00728 203124010193 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 203124010194 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185 203124010195 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 203124010196 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 203124010197 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 203124010198 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 203124010199 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010200 binding surface 203124010201 TPR motif; other site 203124010202 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124010203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010204 binding surface 203124010205 TPR motif; other site 203124010206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010207 TPR motif; other site 203124010208 binding surface 203124010209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010210 TPR motif; other site 203124010211 binding surface 203124010212 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 203124010213 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 203124010214 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 203124010215 active site 203124010216 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124010217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124010218 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 203124010219 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 203124010220 G1 box; other site 203124010221 putative GEF interaction site [polypeptide binding]; other site 203124010222 GTP/Mg2+ binding site [chemical binding]; other site 203124010223 Switch I region; other site 203124010224 G2 box; other site 203124010225 G3 box; other site 203124010226 Switch II region; other site 203124010227 G4 box; other site 203124010228 G5 box; other site 203124010229 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 203124010230 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 203124010231 Fe-S metabolism associated domain; Region: SufE; cl00951 203124010232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 203124010233 salt bridge; other site 203124010234 non-specific DNA binding site [nucleotide binding]; other site 203124010235 sequence-specific DNA binding site [nucleotide binding]; other site 203124010236 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 203124010237 Peptidase family M41; Region: Peptidase_M41; pfam01434 203124010238 FOG: CBS domain [General function prediction only]; Region: COG0517 203124010239 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_7; cd04620 203124010240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 203124010241 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 203124010242 putative active site [active] 203124010243 heme pocket [chemical binding]; other site 203124010244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 203124010245 putative active site [active] 203124010246 heme pocket [chemical binding]; other site 203124010247 GAF domain; Region: GAF; cl00853 203124010248 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124010249 GAF domain; Region: GAF; cl00853 203124010250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 203124010251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124010252 ATP binding site [chemical binding]; other site 203124010253 Mg2+ binding site [ion binding]; other site 203124010254 G-X-G motif; other site 203124010255 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 203124010256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124010257 active site 203124010258 phosphorylation site [posttranslational modification] 203124010259 intermolecular recognition site; other site 203124010260 Response regulator receiver domain; Region: Response_reg; pfam00072 203124010261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124010262 active site 203124010263 phosphorylation site [posttranslational modification] 203124010264 intermolecular recognition site; other site 203124010265 dimerization interface [polypeptide binding]; other site 203124010266 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 203124010267 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 203124010268 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 203124010269 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124010270 Walker A/P-loop; other site 203124010271 ATP binding site [chemical binding]; other site 203124010272 Archaeal ATPase; Region: Arch_ATPase; pfam01637 203124010273 Mechanosensitive ion channel; Region: MS_channel; pfam00924 203124010274 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 203124010275 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 203124010276 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 203124010277 SOUL heme-binding protein; Region: SOUL; pfam04832 203124010278 CHAT domain; Region: CHAT; cl02083 203124010279 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(; Region: BluB; cd02145 203124010280 putative FMN binding site [chemical binding]; other site 203124010281 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 203124010282 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 203124010283 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 203124010284 dimerization interface [polypeptide binding]; other site 203124010285 active site 203124010286 Protein of unknown function (DUF2805); Region: DUF2805; cl11923 203124010287 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 203124010288 S-layer homology domain; Region: SLH; pfam00395 203124010289 Membrane fusogenic activity; Region: BMFP; cl01115 203124010290 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 203124010291 S-layer homology domain; Region: SLH; pfam00395 203124010292 Membrane fusogenic activity; Region: BMFP; cl01115 203124010293 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 203124010294 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124010295 active site 203124010296 ATP binding site [chemical binding]; other site 203124010297 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124010298 substrate binding site [chemical binding]; other site 203124010299 activation loop (A-loop); other site 203124010300 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124010301 structural tetrad; other site 203124010302 Protein of unknown function (DUF423); Region: DUF423; cl01008 203124010303 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 203124010304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 203124010305 S-adenosylmethionine binding site [chemical binding]; other site 203124010306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124010307 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 203124010308 substrate binding pocket [chemical binding]; other site 203124010309 Ion transport protein; Region: Ion_trans; pfam00520 203124010310 Ion channel; Region: Ion_trans_2; cl11596 203124010311 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 203124010312 membrane-bound complex binding site; other site 203124010313 hinge residues; other site 203124010314 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 203124010315 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 203124010316 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203124010317 ATP binding site [chemical binding]; other site 203124010318 putative Mg++ binding site [ion binding]; other site 203124010319 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 203124010320 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 203124010321 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 203124010322 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 203124010323 HsdM N-terminal domain; Region: HsdM_N; pfam12161 203124010324 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 203124010325 active site 203124010326 dimer interface [polypeptide binding]; other site 203124010327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124010328 AIR carboxylase; Region: AIRC; cl00310 203124010329 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 203124010330 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases...; Region: sialate_O-acetylesterase_like2; cd01828 203124010331 active site 203124010332 catalytic triad [active] 203124010333 oxyanion hole [active] 203124010334 LytB protein; Region: LYTB; cl00507 203124010335 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 203124010336 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 203124010337 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 203124010338 Walker A/P-loop; other site 203124010339 ATP binding site [chemical binding]; other site 203124010340 Q-loop/lid; other site 203124010341 ABC transporter signature motif; other site 203124010342 Walker B; other site 203124010343 D-loop; other site 203124010344 H-loop/switch region; other site 203124010345 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 203124010346 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 203124010347 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 203124010348 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 203124010349 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 203124010350 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124010351 Photosystem II protein Y (PsbY); Region: PsbY; cl05675 203124010352 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 203124010353 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 203124010354 trimer interface [polypeptide binding]; other site 203124010355 putative metal binding site [ion binding]; other site 203124010356 Protein of unknown function (DUF2396); Region: DUF2396; cl09868 203124010357 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 203124010358 active site 203124010359 metal binding site [ion binding]; metal-binding site 203124010360 methionine aminopeptidase; Reviewed; Region: PRK07281 203124010361 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 203124010362 active site 203124010363 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 203124010364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124010365 active site 203124010366 phosphorylation site [posttranslational modification] 203124010367 intermolecular recognition site; other site 203124010368 dimerization interface [polypeptide binding]; other site 203124010369 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 203124010370 DNA binding residues [nucleotide binding] 203124010371 dimerization interface [polypeptide binding]; other site 203124010372 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 203124010373 Domain of unknown function (DUF3474); Region: DUF3474; pfam11960 203124010374 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 203124010375 putative di-iron ligands [ion binding]; other site 203124010376 tryptophan synthase; Region: PLN02591 203124010377 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 203124010378 substrate binding site [chemical binding]; other site 203124010379 active site 203124010380 catalytic residues [active] 203124010381 heterodimer interface [polypeptide binding]; other site 203124010382 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 203124010383 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 203124010384 Peptidase family U32; Region: Peptidase_U32; cl03113 203124010385 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 203124010386 Calx-beta domain; Region: Calx-beta; cl02522 203124010387 Calx-beta domain; Region: Calx-beta; cl02522 203124010388 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 203124010389 Calx-beta domain; Region: Calx-beta; cl02522 203124010390 Calx-beta domain; Region: Calx-beta; cl02522 203124010391 sodium/calcium exchanger 1; Region: caca; TIGR00845 203124010392 Calx-beta domain; Region: Calx-beta; cl02522 203124010393 Uncharacterized conserved protein [Function unknown]; Region: COG3391 203124010394 FG-GAP repeat; Region: FG-GAP; pfam01839 203124010395 Calx-beta domain; Region: Calx-beta; cl02522 203124010396 Calx-beta domain; Region: Calx-beta; cl02522 203124010397 Calx-beta domain; Region: Calx-beta; cl02522 203124010398 Calx-beta domain; Region: Calx-beta; cl02522 203124010399 Calx-beta domain; Region: Calx-beta; cl02522 203124010400 Peptidase family U32; Region: Peptidase_U32; cl03113 203124010401 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 203124010402 putative active site [active] 203124010403 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 203124010404 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 203124010405 active site 203124010406 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 203124010407 Ligand Binding Site [chemical binding]; other site 203124010408 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 203124010409 Ligand Binding Site [chemical binding]; other site 203124010410 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 203124010411 catalytic loop [active] 203124010412 iron binding site [ion binding]; other site 203124010413 kinesin-12 family protein; Provisional; Region: PLN03188 203124010414 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 203124010415 Outer membrane efflux protein; Region: OEP; pfam02321 203124010416 Outer membrane efflux protein; Region: OEP; pfam02321 203124010417 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 203124010418 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 203124010419 Protein of unknown function (DUF512); Region: DUF512; pfam04459 203124010420 elongation factor G; Reviewed; Region: PRK00007 203124010421 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 203124010422 G1 box; other site 203124010423 putative GEF interaction site [polypeptide binding]; other site 203124010424 GTP/Mg2+ binding site [chemical binding]; other site 203124010425 Switch I region; other site 203124010426 G2 box; other site 203124010427 G3 box; other site 203124010428 Switch II region; other site 203124010429 G4 box; other site 203124010430 G5 box; other site 203124010431 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 203124010432 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 203124010433 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 203124010434 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 203124010435 GST_C family, ECM4-like subfamily; composed of predominantly uncharacterized and taxonomically diverse proteins with similarity to the translation product of the Saccharomyces cerevisiae gene ECM4. ECM4, a gene of unknown function, is involved in cell...; Region: GST_C_ECM4_like; cd03190 203124010436 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 203124010437 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 203124010438 substrate binding pocket [chemical binding]; other site 203124010439 membrane-bound complex binding site; other site 203124010440 hinge residues; other site 203124010441 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 203124010442 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 203124010443 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 203124010444 C-terminal peptidase (prc); Region: prc; TIGR00225 203124010445 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 203124010446 protein binding site [polypeptide binding]; other site 203124010447 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 203124010448 Catalytic dyad [active] 203124010449 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons...; Region: RT_like; cl02808 203124010450 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 203124010451 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 203124010452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124010453 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 203124010454 cofactor binding site; other site 203124010455 DNA binding site [nucleotide binding] 203124010456 substrate interaction site [chemical binding]; other site 203124010457 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 203124010458 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 203124010459 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 203124010460 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 203124010461 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 203124010462 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 203124010463 putative active site [active] 203124010464 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 203124010465 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 203124010466 active site residue [active] 203124010467 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 203124010468 active site residue [active] 203124010469 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 203124010470 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 203124010471 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 203124010472 tellurite resistance protein terB; Region: terB; cd07176 203124010473 putative metal binding site [ion binding]; other site 203124010474 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 203124010475 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 203124010476 active site 203124010477 catalytic tetrad [active] 203124010478 Noggin; Region: Noggin; pfam05806 203124010479 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cd00018 203124010480 DNA binding site [nucleotide binding] 203124010481 NeuB family; Region: NeuB; cl00496 203124010482 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 203124010483 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 203124010484 DNA photolyase; Region: DNA_photolyase; pfam00875 203124010485 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 203124010486 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 203124010487 catalytic loop [active] 203124010488 iron binding site [ion binding]; other site 203124010489 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 203124010490 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 203124010491 classical (c) SDRs; Region: SDR_c; cd05233 203124010492 NAD(P) binding site [chemical binding]; other site 203124010493 active site 203124010494 Quinolinate synthetase A protein; Region: NadA; cl00420 203124010495 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124010496 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 203124010497 Integrase core domain; Region: rve; cl01316 203124010498 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124010499 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124010500 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 203124010501 Uncharacterised BCR, COG1649; Region: DUF187; pfam02638 203124010502 homoserine dehydrogenase; Provisional; Region: PRK06349 203124010503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124010504 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 203124010505 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 203124010506 FemAB family; Region: FemAB; cl11444 203124010507 Protein of unknown function, DUF482; Region: DUF482; pfam04339 203124010508 cytosine deaminase-like protein; Validated; Region: PRK07583 203124010509 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 203124010510 active site 203124010511 Protein of unknown function (DUF561); Region: DUF561; pfam04481 203124010512 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124010513 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124010514 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124010515 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 203124010516 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 203124010517 Peptidase family M23; Region: Peptidase_M23; pfam01551 203124010518 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 203124010519 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 203124010520 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124010521 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 203124010522 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 203124010523 MOSC domain; Region: MOSC; pfam03473 203124010524 O-Antigen ligase; Region: Wzy_C; cl04850 203124010525 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 203124010526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 203124010527 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 203124010528 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 203124010529 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 203124010530 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 203124010531 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 203124010532 NAD(P) binding site [chemical binding]; other site 203124010533 putative active site [active] 203124010534 Domain of unknown function (DUF364); Region: DUF364; cl00885 203124010535 CHASE2 domain; Region: CHASE2; cl01732 203124010536 cyclase homology domain; Region: CHD; cd07302 203124010537 nucleotidyl binding site; other site 203124010538 metal binding site [ion binding]; metal-binding site 203124010539 dimer interface [polypeptide binding]; other site 203124010540 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 203124010541 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 203124010542 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124010543 active site 203124010544 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 203124010545 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 203124010546 Mg++ binding site [ion binding]; other site 203124010547 putative catalytic motif [active] 203124010548 putative substrate binding site [chemical binding]; other site 203124010549 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 203124010550 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 203124010551 AmiB activator; Provisional; Region: PRK11637 203124010552 PRTRC system protein D; Region: PRTRC_D; TIGR03739 203124010553 cell division protein; Validated; Region: ftsH; CHL00176 203124010554 FtsH Extracellular; Region: FtsH_ext; pfam06480 203124010555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124010556 Walker A motif; other site 203124010557 ATP binding site [chemical binding]; other site 203124010558 Walker B motif; other site 203124010559 arginine finger; other site 203124010560 Peptidase family M41; Region: Peptidase_M41; pfam01434 203124010561 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 203124010562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124010563 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 203124010564 proline aminopeptidase P II; Provisional; Region: PRK10879 203124010565 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 203124010566 active site 203124010567 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 203124010568 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 203124010569 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 203124010570 intersubunit interface [polypeptide binding]; other site 203124010571 active site 203124010572 catalytic residue [active] 203124010573 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 203124010574 Recombination protein O N terminal; Region: RecO_N; pfam11967 203124010575 Recombination protein O C terminal; Region: RecO_C; pfam02565 203124010576 H+ Antiporter protein; Region: 2A0121; TIGR00900 203124010577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203124010578 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 203124010579 dimer interface [polypeptide binding]; other site 203124010580 active site 203124010581 aspartate-rich active site metal binding site; other site 203124010582 allosteric magnesium binding site [ion binding]; other site 203124010583 Schiff base residues; other site 203124010584 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 203124010585 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 203124010586 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 203124010587 active site 203124010588 metal binding site [ion binding]; metal-binding site 203124010589 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 203124010590 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124010591 G1 box; other site 203124010592 GTP/Mg2+ binding site [chemical binding]; other site 203124010593 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 203124010594 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 203124010595 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203124010596 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 203124010597 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 203124010598 homodecamer interface [polypeptide binding]; other site 203124010599 GTP cyclohydrolase I; Provisional; Region: PLN03044 203124010600 active site 203124010601 putative catalytic site residues [active] 203124010602 zinc binding site [ion binding]; other site 203124010603 GTP-CH-I/GFRP interaction surface; other site 203124010604 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 203124010605 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 203124010606 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 203124010607 Cytochrome c; Region: Cytochrom_C; cl11414 203124010608 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 203124010609 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 203124010610 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 203124010611 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 203124010612 domain interfaces; other site 203124010613 active site 203124010614 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 203124010615 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 203124010616 GLases (alpha-1,4-glucan lyases) are glycosyl hydrolase family 31 (GH31) enzymes that degrade alpha-1,4-glucans and maltooligosaccharides via a nonhydrolytic pathway to yield 1,5-D-anhydrofructose from the nonreducing end. GLases cleave the bond...; Region: GH31_lyase_GLase; cd06601 203124010617 putative active site [active] 203124010618 putative catalytic site [active] 203124010619 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 203124010620 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 203124010621 FOG: WD40 repeat [General function prediction only]; Region: COG2319 203124010622 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124010623 structural tetrad; other site 203124010624 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124010625 structural tetrad; other site 203124010626 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 203124010627 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 203124010628 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010629 binding surface 203124010630 TPR motif; other site 203124010631 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010632 binding surface 203124010633 TPR motif; other site 203124010634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 203124010635 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 203124010636 RimM N-terminal domain; Region: RimM; pfam01782 203124010637 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 203124010638 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869 203124010639 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 203124010640 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 203124010641 putative NAD(P) binding site [chemical binding]; other site 203124010642 active site 203124010643 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 203124010644 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 203124010645 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 203124010646 active site 203124010647 substrate binding site [chemical binding]; other site 203124010648 cosubstrate binding site; other site 203124010649 catalytic site [active] 203124010650 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 203124010651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 203124010652 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 203124010653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 203124010654 ATP binding site [chemical binding]; other site 203124010655 putative Mg++ binding site [ion binding]; other site 203124010656 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 203124010657 Dihaem cytochrome c; Region: DHC; pfam09626 203124010658 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 203124010659 Domain of unknown function DUF143; Region: DUF143; cl00519 203124010660 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 203124010661 L-asparaginase II; Region: Asparaginase_II; cl01842 203124010662 Transposase [DNA replication, recombination, and repair]; Region: COG5421 203124010663 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 203124010664 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 203124010665 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124010666 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124010667 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124010668 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 203124010669 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 203124010670 TPP-binding site [chemical binding]; other site 203124010671 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 203124010672 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 203124010673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 203124010674 motif II; other site 203124010675 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 203124010676 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 203124010677 active site 203124010678 Zn binding site [ion binding]; other site 203124010679 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 203124010680 active site 203124010681 intersubunit interface [polypeptide binding]; other site 203124010682 Zn2+ binding site [ion binding]; other site 203124010683 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 203124010684 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 203124010685 cofactor binding site; other site 203124010686 DNA binding site [nucleotide binding] 203124010687 substrate interaction site [chemical binding]; other site 203124010688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124010689 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 203124010690 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 203124010691 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 203124010692 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 203124010693 Surface antigen; Region: Bac_surface_Ag; cl03097 203124010694 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 203124010695 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 203124010696 ATP binding site [chemical binding]; other site 203124010697 active site 203124010698 substrate binding site [chemical binding]; other site 203124010699 Bacterial SH3 domain; Region: SH3_3; cl02551 203124010700 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 203124010701 Amidinotransferase; Region: Amidinotransf; cl12043 203124010702 Uncharacterized conserved protein [Function unknown]; Region: COG1915 203124010703 LOR/SDH bifunctional enzyme conserved region; Region: Saccharop_dh_N; pfam04455 203124010704 S-adenosylmethionine synthetase; Validated; Region: PRK05250 203124010705 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 203124010706 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 203124010707 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 203124010708 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 203124010709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 203124010710 motif II; other site 203124010711 30S ribosomal protein S1; Reviewed; Region: PRK07400 203124010712 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 203124010713 RNA binding site [nucleotide binding]; other site 203124010714 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 203124010715 RNA binding site [nucleotide binding]; other site 203124010716 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 203124010717 RNA binding site [nucleotide binding]; other site 203124010718 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 203124010719 ATP cone domain; Region: ATP-cone; pfam03477 203124010720 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 203124010721 Photosystem II protein; Region: PSII; cl08223 203124010722 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 203124010723 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 203124010724 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as...; Region: KaiB_like; cd02978 203124010725 tetramer interface [polypeptide binding]; other site 203124010726 dimer interface [polypeptide binding]; other site 203124010727 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 203124010728 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124010729 Walker A motif; other site 203124010730 ATP binding site [chemical binding]; other site 203124010731 Walker B motif; other site 203124010732 Protein of unknown function DUF262; Region: DUF262; cl14890 203124010733 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 203124010734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124010735 cofactor binding site; other site 203124010736 DNA binding site [nucleotide binding] 203124010737 substrate interaction site [chemical binding]; other site 203124010738 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 203124010739 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 203124010740 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124010741 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 203124010742 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 203124010743 hypothetical protein; Validated; Region: PRK07413 203124010744 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 203124010745 Walker A motif; other site 203124010746 homodimer interface [polypeptide binding]; other site 203124010747 ATP binding site [chemical binding]; other site 203124010748 hydroxycobalamin binding site [chemical binding]; other site 203124010749 Walker B motif; other site 203124010750 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 203124010751 Walker A motif; other site 203124010752 homodimer interface [polypeptide binding]; other site 203124010753 ATP binding site [chemical binding]; other site 203124010754 hydroxycobalamin binding site [chemical binding]; other site 203124010755 Walker B motif; other site 203124010756 ABC-2 type transporter; Region: ABC2_membrane; cl11417 203124010757 TIGR00268 family protein; Region: TIGR00268 203124010758 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 203124010759 Ligand Binding Site [chemical binding]; other site 203124010760 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 203124010761 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 203124010762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124010763 homodimer interface [polypeptide binding]; other site 203124010764 catalytic residue [active] 203124010765 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 203124010766 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 203124010767 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 203124010768 FAD binding site [chemical binding]; other site 203124010769 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 203124010770 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 203124010771 active site 203124010772 HIGH motif; other site 203124010773 dimer interface [polypeptide binding]; other site 203124010774 KMSKS motif; other site 203124010775 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 203124010776 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 203124010777 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 203124010778 Domain of unknown function DUF37; Region: DUF37; cl00506 203124010779 Aspartoacylase (ASPA) belongs to the Succinylglutamate desuccinylase/aspartoacylase subfamily of the M14 family of metallocarboxypeptidases. ASPA (also known as aminoacylase 2; EC:3.5.1.15) cleaves N-acetyl L-aspartic acid (NAA) into aspartate and...; Region: M14_ASPA; cd06909 203124010780 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 203124010781 active site 203124010782 Zn-binding site [ion binding]; other site 203124010783 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 203124010784 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 203124010785 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 203124010786 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 203124010787 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 203124010788 RNA/DNA binding site [nucleotide binding]; other site 203124010789 RRM dimerization site [polypeptide binding]; other site 203124010790 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 203124010791 RNA/DNA binding site [nucleotide binding]; other site 203124010792 RRM dimerization site [polypeptide binding]; other site 203124010793 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 203124010794 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 203124010795 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 203124010796 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 203124010797 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 203124010798 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 203124010799 Ribonuclease P; Region: Ribonuclease_P; cl00457 203124010800 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 203124010801 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 203124010802 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 203124010803 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 203124010804 G-X-X-G motif; other site 203124010805 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 203124010806 RxxxH motif; other site 203124010807 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 203124010808 Ycf46; Provisional; Region: ycf46; CHL00195 203124010809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 203124010810 Walker A motif; other site 203124010811 ATP binding site [chemical binding]; other site 203124010812 Walker B motif; other site 203124010813 arginine finger; other site 203124010814 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 203124010815 homotrimer interaction site [polypeptide binding]; other site 203124010816 zinc binding site [ion binding]; other site 203124010817 CDP-binding sites; other site 203124010818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010819 binding surface 203124010820 TPR motif; other site 203124010821 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 203124010822 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 203124010823 putative ligand binding site [chemical binding]; other site 203124010824 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 203124010825 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 203124010826 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 203124010827 AIR carboxylase; Region: AIRC; cl00310 203124010828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010829 binding surface 203124010830 TPR motif; other site 203124010831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010832 TPR motif; other site 203124010833 binding surface 203124010834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010835 binding surface 203124010836 TPR motif; other site 203124010837 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 203124010838 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 203124010839 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 203124010840 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 203124010841 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124010842 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 203124010843 putative active site [active] 203124010844 putative NTP binding site [chemical binding]; other site 203124010845 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 203124010846 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124010847 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 203124010848 putative active site [active] 203124010849 putative NTP binding site [chemical binding]; other site 203124010850 putative nucleic acid binding site [nucleotide binding]; other site 203124010851 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 203124010852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124010853 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 203124010854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124010855 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 203124010856 putative active site [active] 203124010857 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_C; cd03414 203124010858 putative active site [active] 203124010859 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 203124010860 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 203124010861 dimer interface [polypeptide binding]; other site 203124010862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124010863 catalytic residue [active] 203124010864 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 203124010865 dimer interface [polypeptide binding]; other site 203124010866 [2Fe-2S] cluster binding site [ion binding]; other site 203124010867 glutathione reductase; Validated; Region: PRK06116 203124010868 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124010869 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124010870 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 203124010871 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_7; cd04620 203124010872 FOG: CBS domain [General function prediction only]; Region: COG0517 203124010873 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 203124010874 FOG: CBS domain [General function prediction only]; Region: COG0517 203124010875 GAF domain; Region: GAF; cl00853 203124010876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 203124010877 dimer interface [polypeptide binding]; other site 203124010878 phosphorylation site [posttranslational modification] 203124010879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203124010880 ATP binding site [chemical binding]; other site 203124010881 Mg2+ binding site [ion binding]; other site 203124010882 G-X-G motif; other site 203124010883 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124010884 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124010885 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124010886 Calx-beta domain; Region: Calx-beta; cl02522 203124010887 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 203124010888 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124010889 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 203124010890 substrate binding pocket [chemical binding]; other site 203124010891 membrane-bound complex binding site; other site 203124010892 hinge residues; other site 203124010893 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 203124010894 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 203124010895 substrate binding pocket [chemical binding]; other site 203124010896 membrane-bound complex binding site; other site 203124010897 hinge residues; other site 203124010898 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 203124010899 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124010900 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 203124010901 active site 203124010902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124010903 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 203124010904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124010905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124010906 Cupin domain; Region: Cupin_2; cl09118 203124010907 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 203124010908 Mechanosensitive ion channel; Region: MS_channel; pfam00924 203124010909 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124010910 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 203124010911 protein I interface; other site 203124010912 D2 interface; other site 203124010913 protein T interface; other site 203124010914 chlorophyll binding site; other site 203124010915 beta carotene binding site; other site 203124010916 pheophytin binding site; other site 203124010917 manganese-stabilizing polypeptide interface; other site 203124010918 CP43 interface; other site 203124010919 protein L interface; other site 203124010920 oxygen evolving complex binding site; other site 203124010921 bromide binding site; other site 203124010922 quinone binding site; other site 203124010923 Fe binding site [ion binding]; other site 203124010924 core light harvesting interface; other site 203124010925 cytochrome b559 alpha subunit interface; other site 203124010926 cytochrome c-550 interface; other site 203124010927 protein J interface; other site 203124010928 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 203124010929 nucleotide binding site/active site [active] 203124010930 HIT family signature motif; other site 203124010931 catalytic residue [active] 203124010932 Mg chelatase-related protein; Region: TIGR00368 203124010933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124010934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010935 binding surface 203124010936 TPR motif; other site 203124010937 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010938 binding surface 203124010939 TPR motif; other site 203124010940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010941 binding surface 203124010942 TPR motif; other site 203124010943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010944 binding surface 203124010945 TPR motif; other site 203124010946 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124010947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010948 TPR motif; other site 203124010949 binding surface 203124010950 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124010951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010952 binding surface 203124010953 TPR motif; other site 203124010954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010955 binding surface 203124010956 TPR motif; other site 203124010957 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010958 TPR motif; other site 203124010959 binding surface 203124010960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010961 binding surface 203124010962 TPR motif; other site 203124010963 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124010964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010965 binding surface 203124010966 TPR motif; other site 203124010967 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 203124010968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010969 binding surface 203124010970 TPR motif; other site 203124010971 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124010972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010973 binding surface 203124010974 TPR motif; other site 203124010975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010976 binding surface 203124010977 TPR motif; other site 203124010978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010979 binding surface 203124010980 TPR motif; other site 203124010981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124010982 binding surface 203124010983 TPR motif; other site 203124010984 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 203124010985 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 203124010986 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124010987 active site 203124010988 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 203124010989 active site 203124010990 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124010991 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 203124010992 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203124010993 active site 203124010994 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 203124010995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 203124010996 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 203124010997 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 203124010998 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 203124010999 G1 box; other site 203124011000 GTP/Mg2+ binding site [chemical binding]; other site 203124011001 Switch I region; other site 203124011002 G2 box; other site 203124011003 Switch II region; other site 203124011004 G3 box; other site 203124011005 G4 box; other site 203124011006 G5 box; other site 203124011007 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 203124011008 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 203124011009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124011010 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203124011011 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 203124011012 active site 203124011013 ATP binding site [chemical binding]; other site 203124011014 substrate binding site [chemical binding]; other site 203124011015 activation loop (A-loop); other site 203124011016 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 203124011017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124011018 binding surface 203124011019 TPR motif; other site 203124011020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124011021 binding surface 203124011022 TPR motif; other site 203124011023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124011024 binding surface 203124011025 TPR motif; other site 203124011026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124011027 binding surface 203124011028 TPR motif; other site 203124011029 Protein kinase domain; Region: Pkinase; pfam00069 203124011030 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203124011031 active site 203124011032 ATP binding site [chemical binding]; other site 203124011033 substrate binding site [chemical binding]; other site 203124011034 activation loop (A-loop); other site 203124011035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124011036 binding surface 203124011037 TPR motif; other site 203124011038 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 203124011039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124011040 binding surface 203124011041 TPR motif; other site 203124011042 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124011043 binding surface 203124011044 TPR motif; other site 203124011045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124011046 binding surface 203124011047 TPR motif; other site 203124011048 Uncharacterized conserved protein [Function unknown]; Region: COG1912 203124011049 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 203124011050 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 203124011051 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124011052 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 203124011053 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 203124011054 dimerization interface [polypeptide binding]; other site 203124011055 putative ATP binding site [chemical binding]; other site 203124011056 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 203124011057 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 203124011058 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 203124011059 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 203124011060 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 203124011061 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 203124011062 Walker A/P-loop; other site 203124011063 ATP binding site [chemical binding]; other site 203124011064 Q-loop/lid; other site 203124011065 ABC transporter signature motif; other site 203124011066 Walker B; other site 203124011067 D-loop; other site 203124011068 H-loop/switch region; other site 203124011069 Membrane transport protein; Region: Mem_trans; cl09117 203124011070 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 203124011071 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 203124011072 Domain of unknown function DUF20; Region: UPF0118; cl00465 203124011073 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 203124011074 BtpA family; Region: BtpA; cl00440 203124011075 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 203124011076 Photosystem II 12 kDa extrinsic protein (PsbU); Region: PsbU; pfam06514 203124011077 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 203124011078 Bacitracin resistance protein BacA; Region: BacA; cl00858 203124011079 Phycobilisome protein; Region: Phycobilisome; cl08227 203124011080 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 203124011081 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 203124011082 putative active site [active] 203124011083 putative NTP binding site [chemical binding]; other site 203124011084 putative nucleic acid binding site [nucleotide binding]; other site 203124011085 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 203124011086 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 203124011087 TRAM domain; Region: TRAM; cl01282 203124011088 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 203124011089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124011090 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 203124011091 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124011092 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 203124011093 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 203124011094 motif 1; other site 203124011095 active site 203124011096 motif 2; other site 203124011097 motif 3; other site 203124011098 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 203124011099 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 203124011100 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 203124011101 HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 203124011102 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 203124011103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 203124011104 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 203124011105 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 203124011106 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 203124011107 cofactor binding site; other site 203124011108 DNA binding site [nucleotide binding] 203124011109 substrate interaction site [chemical binding]; other site 203124011110 Uncharacterized conserved protein [Function unknown]; Region: COG1565 203124011111 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 203124011112 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 203124011113 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 203124011114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124011115 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 203124011116 Response regulator receiver domain; Region: Response_reg; pfam00072 203124011117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124011118 active site 203124011119 phosphorylation site [posttranslational modification] 203124011120 intermolecular recognition site; other site 203124011121 dimerization interface [polypeptide binding]; other site 203124011122 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 203124011123 GAF domain; Region: GAF; cl00853 203124011124 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 203124011125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 203124011126 iron-sulfur cluster binding protein, putative; Region: TIGR00276 203124011127 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 203124011128 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 203124011129 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 203124011130 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 203124011131 trimer interface [polypeptide binding]; other site 203124011132 active site 203124011133 UDP-GlcNAc binding site [chemical binding]; other site 203124011134 lipid binding site [chemical binding]; lipid-binding site 203124011135 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124011136 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 203124011137 Slx4 endonuclease; Region: Slx4; pfam09494 203124011138 Integrase core domain; Region: rve; cl01316 203124011139 HAS barrel domain; Region: HAS-barrel; pfam09378 203124011140 HerA helicase [Replication, recombination, and repair]; Region: COG0433 203124011141 Domain of unknown function DUF87; Region: DUF87; pfam01935 203124011142 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 203124011143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124011144 Transposase; Region: HTH_Tnp_IS630; pfam01710 203124011145 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124011146 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 203124011147 Integrase core domain; Region: rve; cl01316 203124011148 Integrase core domain; Region: rve; cl01316 203124011149 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124011150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 203124011151 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124011152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124011153 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203124011154 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 203124011155 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 203124011156 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 203124011157 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 203124011158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124011159 photosystem I P subunit (PSI-P); Region: PLN02777 203124011160 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 203124011161 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 203124011162 hinge; other site 203124011163 active site 203124011164 CHAD domain; Region: CHAD; cl10506 203124011165 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 203124011166 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 203124011167 putative NAD(P) binding site [chemical binding]; other site 203124011168 Cobalt transport protein; Region: CbiQ; cl00463 203124011169 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 203124011170 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 203124011171 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 203124011172 catalytic residue [active] 203124011173 Probable transposase; Region: OrfB_IS605; pfam01385 203124011174 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 203124011175 Protein of unknown function (DUF552); Region: DUF552; cl00775 203124011176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124011177 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 203124011178 tRNA mo(5)U34 methyltransferase; Provisional; Region: PRK15068 203124011179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 203124011180 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 203124011181 activation loop (A-loop); other site 203124011182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 203124011183 binding surface 203124011184 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124011185 Integrase core domain; Region: rve; cl01316 203124011186 Protein-arginine deiminase (PAD); Region: PAD; pfam03068 203124011187 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 203124011188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 203124011189 active site 203124011190 phosphorylation site [posttranslational modification] 203124011191 intermolecular recognition site; other site 203124011192 dimerization interface [polypeptide binding]; other site 203124011193 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 203124011194 DNA binding site [nucleotide binding] 203124011195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 203124011196 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 203124011197 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 203124011198 active site 203124011199 dinuclear metal binding site [ion binding]; other site 203124011200 dimerization interface [polypeptide binding]; other site 203124011201 Voltage-dependent potassium channel; Provisional; Region: PLN03192 203124011202 Ion channel; Region: Ion_trans_2; cl11596 203124011203 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 203124011204 ligand binding site [chemical binding]; other site 203124011205 flexible hinge region; other site 203124011206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124011207 binding surface 203124011208 TPR motif; other site 203124011209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124011210 binding surface 203124011211 TPR motif; other site 203124011212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124011213 binding surface 203124011214 TPR motif; other site 203124011215 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 203124011216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124011217 binding surface 203124011218 TPR motif; other site 203124011219 Predicted lysozyme (DUF847); Region: DUF847; pfam05838 203124011220 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 203124011221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124011222 Entner-Doudoroff aldolase; Region: eda; TIGR01182 203124011223 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 203124011224 active site 203124011225 intersubunit interface [polypeptide binding]; other site 203124011226 catalytic residue [active] 203124011227 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 203124011228 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 203124011229 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 203124011230 intersubunit interface [polypeptide binding]; other site 203124011231 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 203124011232 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 203124011233 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 203124011234 ABC-ATPase subunit interface; other site 203124011235 dimer interface [polypeptide binding]; other site 203124011236 putative PBP binding regions; other site 203124011237 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 203124011238 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 203124011239 ligand binding site [chemical binding]; other site 203124011240 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 203124011241 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 203124011242 inhibitor-cofactor binding pocket; inhibition site 203124011243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124011244 catalytic residue [active] 203124011245 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 203124011246 CHAT domain; Region: CHAT; cl02083 203124011247 CHAT domain; Region: CHAT; cl02083 203124011248 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 203124011249 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 203124011250 RNA polymerase sigma factor; Provisional; Region: PRK12519 203124011251 Domain of unknown function (DUF205); Region: DUF205; cl00410 203124011252 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 203124011253 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 203124011254 B12 binding site [chemical binding]; other site 203124011255 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 203124011256 conserved hypothetical protein; Region: TIGR03492 203124011257 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124011258 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 203124011259 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase...; Region: vWA_Magnesium_chelatase; cd01451 203124011260 metal ion-dependent adhesion site (MIDAS); other site 203124011261 RDD family; Region: RDD; cl00746 203124011262 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 203124011263 GUN4-like; Region: GUN4; pfam05419 203124011264 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 203124011265 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 203124011266 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 203124011267 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 203124011268 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 203124011269 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 203124011270 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124011271 structural tetrad; other site 203124011272 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 203124011273 PAS domain S-box; Region: sensory_box; TIGR00229 203124011274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 203124011275 putative active site [active] 203124011276 heme pocket [chemical binding]; other site 203124011277 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 203124011278 metal binding site [ion binding]; metal-binding site 203124011279 active site 203124011280 I-site; other site 203124011281 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 203124011282 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 203124011283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203124011284 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cd00200 203124011285 structural tetrad; other site 203124011286 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 203124011287 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 203124011288 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124011289 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124011290 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 203124011291 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124011292 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 203124011293 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 203124011294 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 203124011295 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 203124011296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 203124011297 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 203124011298 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 203124011299 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 203124011300 [2Fe-2S] cluster binding site [ion binding]; other site 203124011301 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 203124011302 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203124011303 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 203124011304 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 203124011305 Walker A/P-loop; other site 203124011306 ATP binding site [chemical binding]; other site 203124011307 Q-loop/lid; other site 203124011308 ABC transporter signature motif; other site 203124011309 Walker B; other site 203124011310 D-loop; other site 203124011311 H-loop/switch region; other site 203124011312 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 203124011313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 203124011314 dimer interface [polypeptide binding]; other site 203124011315 conserved gate region; other site 203124011316 putative PBP binding loops; other site 203124011317 ABC-ATPase subunit interface; other site 203124011318 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 203124011319 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 203124011320 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 203124011321 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 203124011322 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 203124011323 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 203124011324 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 203124011325 Walker A/P-loop; other site 203124011326 ATP binding site [chemical binding]; other site 203124011327 Q-loop/lid; other site 203124011328 ABC transporter signature motif; other site 203124011329 Walker B; other site 203124011330 D-loop; other site 203124011331 H-loop/switch region; other site 203124011332 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 203124011333 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 203124011334 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 203124011335 Walker A/P-loop; other site 203124011336 ATP binding site [chemical binding]; other site 203124011337 Q-loop/lid; other site 203124011338 ABC transporter signature motif; other site 203124011339 Walker B; other site 203124011340 D-loop; other site 203124011341 H-loop/switch region; other site 203124011342 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 203124011343 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 203124011344 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 203124011345 active site 203124011346 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 203124011347 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124011348 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 203124011349 active site 203124011350 dimer interface [polypeptide binding]; other site 203124011351 metal binding site [ion binding]; metal-binding site 203124011352 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 203124011353 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 203124011354 dimer interface [polypeptide binding]; other site 203124011355 catalytic triad [active] 203124011356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 203124011357 GAF domain; Region: GAF; cl00853 203124011358 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 203124011359 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 203124011360 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 203124011361 anti sigma factor interaction site; other site 203124011362 regulatory phosphorylation site [posttranslational modification]; other site 203124011363 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 203124011364 Isoamylase N-terminus domain. Isoamylase (aka glycogen 6-glucanohydrolase) is one of the starch-debranching enzymes that catalyzes the hydrolysis of alpha-1,6-glucosidic linkages specific in alpha-glucans such as amylopectin or glycogen. Isoamylase...; Region: Isoamylase_N_term; cd02852 203124011365 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 203124011366 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 203124011367 anti sigma factor interaction site; other site 203124011368 regulatory phosphorylation site [posttranslational modification]; other site 203124011369 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 203124011370 dimerization interface [polypeptide binding]; other site 203124011371 putative active cleft [active] 203124011372 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 203124011373 conserved cys residue [active] 203124011374 EthD protein; Region: EthD; cl06234 203124011375 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 203124011376 Multicopper oxidase; Region: Cu-oxidase; cl14658 203124011377 Multicopper oxidase; Region: Cu-oxidase; cl14658 203124011378 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124011379 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 203124011380 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 203124011381 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 203124011382 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 203124011383 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 203124011384 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 203124011385 glutamine binding [chemical binding]; other site 203124011386 catalytic triad [active] 203124011387 glycine dehydrogenase; Provisional; Region: PRK05367 203124011388 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 203124011389 tetramer interface [polypeptide binding]; other site 203124011390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124011391 catalytic residue [active] 203124011392 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 203124011393 tetramer interface [polypeptide binding]; other site 203124011394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203124011395 catalytic residue [active] 203124011396 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 203124011397 lipoyl attachment site [posttranslational modification]; other site 203124011398 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 203124011399 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 203124011400 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 203124011401 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 203124011402 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 203124011403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124011404 TPR motif; other site 203124011405 binding surface 203124011406 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 203124011407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124011408 TPR motif; other site 203124011409 binding surface 203124011410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 203124011411 binding surface 203124011412 TPR motif; other site 203124011413 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 203124011414 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 203124011415 dimer interface [polypeptide binding]; other site 203124011416 decamer (pentamer of dimers) interface [polypeptide binding]; other site 203124011417 catalytic triad [active] 203124011418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 203124011419 Cytochrome P450; Region: p450; cl12078 203124011420 Cytochrome P450; Region: p450; cl12078 203124011421 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 203124011422 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124011423 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 203124011424 Phycobilisome protein; Region: Phycobilisome; cl08227 203124011425 Phycobilisome protein; Region: Phycobilisome; cl08227 203124011426 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 203124011427 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 203124011428 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 203124011429 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 203124011430 putative metal binding site [ion binding]; other site 203124011431 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 203124011432 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 203124011433 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 203124011434 protein binding site [polypeptide binding]; other site 203124011435 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 203124011436 active site 203124011437 catalytic residues [active] 203124011438 metal binding site [ion binding]; metal-binding site 203124011439 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 203124011440 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 203124011441 putative metal binding site [ion binding]; other site 203124011442 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 203124011443 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 203124011444 putative metal binding site [ion binding]; other site 203124011445 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 203124011446 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 203124011447 tetramer interface [polypeptide binding]; other site 203124011448 TPP-binding site [chemical binding]; other site 203124011449 heterodimer interface [polypeptide binding]; other site 203124011450 phosphorylation loop region [posttranslational modification] 203124011451 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 203124011452 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 203124011453 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 203124011454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 203124011455 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 203124011456 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 203124011457 DNA binding residues [nucleotide binding] 203124011458 Peptidase family M23; Region: Peptidase_M23; pfam01551 203124011459 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 203124011460 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 203124011461 putative ligand binding site [chemical binding]; other site 203124011462 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 203124011463 Protein export membrane protein; Region: SecD_SecF; cl14618 203124011464 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 203124011465 Protein export membrane protein; Region: SecD_SecF; cl14618 203124011466 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 203124011467 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 203124011468 alpha subunit interface [polypeptide binding]; other site 203124011469 TPP binding site [chemical binding]; other site 203124011470 heterodimer interface [polypeptide binding]; other site 203124011471 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780