-- dump date 20111120_182929 -- class Genbank::misc_feature -- table misc_feature_note -- id note 218496000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 218496000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 218496000003 Walker A motif; other site 218496000004 ATP binding site [chemical binding]; other site 218496000005 Walker B motif; other site 218496000006 arginine finger; other site 218496000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 218496000008 DnaA box-binding interface [nucleotide binding]; other site 218496000009 Bacterial dnaA protein Score = 573.7 E-value = 8.2e-170 218496000010 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000011 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 218496000012 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000013 PS01008 DnaA protein signature. 218496000014 DNA polymerase III subunit beta; Validated; Region: PRK07761 218496000015 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 218496000016 putative DNA binding surface [nucleotide binding]; other site 218496000017 dimer interface [polypeptide binding]; other site 218496000018 beta-clamp/clamp loader binding surface; other site 218496000019 beta-clamp/translesion DNA polymerase binding surface; other site 218496000020 DNA polymerase III beta subunit, N-terminal domain Score = 115.6 E-value = 6.6e-32 218496000021 DNA polymerase III beta subunit, central domain Score = 60.4 E-value = 2.7e-15 218496000022 DNA polymerase III beta subunit, C-terminal domain Score = 1.7 E-value = 0.00015 218496000023 recombination protein F; Reviewed; Region: recF; PRK00064 218496000024 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 218496000025 Walker A/P-loop; other site 218496000026 ATP binding site [chemical binding]; other site 218496000027 Q-loop/lid; other site 218496000028 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 218496000029 ABC transporter signature motif; other site 218496000030 Walker B; other site 218496000031 D-loop; other site 218496000032 H-loop/switch region; other site 218496000033 RecF/RecN/SMC N terminal domain Score = -8.3 E-value = 6e-07 218496000034 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000035 PS00618 RecF protein signature 2. 218496000036 Protein of unknown function (DUF721); Region: DUF721; cl02324 218496000037 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 218496000038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 218496000039 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 218496000040 anchoring element; other site 218496000041 dimer interface [polypeptide binding]; other site 218496000042 ATP binding site [chemical binding]; other site 218496000043 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 218496000044 active site 218496000045 putative metal-binding site [ion binding]; other site 218496000046 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 218496000047 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Score = 94.1 E-value = 2e-25 218496000048 DNA gyrase B Score = 261.5 E-value = 7.7e-76 218496000049 PS00177 DNA topoisomerase II signature. 218496000050 Toprim domain Score = 47.8 E-value = 1.7e-11 218496000051 DNA gyrase B subunit, carboxyl terminus Score = 135.1 E-value = 8.7e-38 218496000052 DNA gyrase subunit A; Validated; Region: PRK05560 218496000053 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 218496000054 CAP-like domain; other site 218496000055 Active site [active] 218496000056 primary dimer interface [polypeptide binding]; other site 218496000057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218496000058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218496000059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218496000060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218496000061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218496000062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218496000063 DNA gyrase/topoisomerase IV, subunit A Score = 899.7 E-value = 6.1e-268 218496000064 DNA gyrase C-terminal domain, beta-propeller Score = 52.8 E-value = 5.4e-13 218496000065 DNA gyrase C-terminal domain, beta-propeller Score = 50.6 E-value = 2.5e-12 218496000066 DNA gyrase C-terminal domain, beta-propeller Score = 48.9 E-value = 7.8e-12 218496000067 DNA gyrase C-terminal domain, beta-propeller Score = 43.8 E-value = 2.7e-10 218496000068 DNA gyrase C-terminal domain, beta-propeller Score = 46.4 E-value = 4.4e-11 218496000069 DNA gyrase C-terminal domain, beta-propeller Score = 31.1 E-value = 1.8e-06 218496000070 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.950) with cleavage site probability 0.633 between residues 64 and 65; signal peptide 218496000071 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 218496000072 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 29-51 and 82-113 218496000073 Thiamine pyrophosphokinase; Region: TPK; cd07995 218496000074 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 218496000075 active site 218496000076 dimerization interface [polypeptide binding]; other site 218496000077 thiamine binding site [chemical binding]; other site 218496000078 Thiamin pyrophosphokinase, catalytic domain Score = 80.0 E-value = 3.5e-21 218496000079 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.460 between residues 40 and 41; signal peptide 218496000080 Rhomboid family; Region: Rhomboid; cl11446 218496000081 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 23-45, 60-82, 89-111, 115-137, 144-166 and 186-205 218496000082 Rhomboid family Score = 144.6 E-value = 1.3e-40 218496000083 Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506 218496000084 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 13-35 and 45-64 218496000085 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 218496000086 Glutamine amidotransferase class-I; Region: GATase; pfam00117 218496000087 glutamine binding [chemical binding]; other site 218496000088 catalytic triad [active] 218496000089 Glutamine amidotransferase class-I Score = 180.3 E-value = 2.2e-51 218496000090 PS00442 Glutamine amidotransferases class-I active site. 218496000091 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.916) with cleavage site probability 0.503 between residues 25 and 26; signal peptide 218496000092 LemA family; Region: LemA; cl00742 218496000093 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 4-26 218496000094 LemA family Score = 254.7 E-value = 9e-74 218496000095 Peptidase family M48; Region: Peptidase_M48; cl12018 218496000096 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.241 between residues 48 and 49; signal peptide 218496000097 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 13-35, 39-61, 154-176 and 186-208 218496000098 Peptidase family M48 Score = 115.6 E-value = 6.5e-32 218496000099 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.767) with cleavage site probability 0.217 between residues 23 and 24; signal peptide 218496000100 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 5-24, 34-56, 63-85 and 95-117 218496000101 Putative Ig domain; Region: He_PIG; cl09256 218496000102 Putative Ig domain; Region: He_PIG; cl09256 218496000103 Putative Ig domain; Region: He_PIG; cl09256 218496000104 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 21-40 218496000105 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 218496000106 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 218496000107 active site 218496000108 catalytic tetrad [active] 218496000109 Aldo/keto reductase family Score = 357.0 E-value = 1.4e-104 218496000110 PS00798 Aldo/keto reductase family signature 1. 218496000111 PS00062 Aldo/keto reductase family signature 2. 218496000112 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 218496000113 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 218496000114 active site 218496000115 substrate binding site [chemical binding]; other site 218496000116 metal binding site [ion binding]; metal-binding site 218496000117 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Score = 14.2 E-value = 0.00014 218496000118 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Score = 11.1 E-value = 3.8e-05 218496000119 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I Score = 147.4 E-value = 1.8e-41 218496000120 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 218496000121 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 218496000122 Phosphorylase family 2 Score = 185.7 E-value = 5.4e-53 218496000123 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.772) with cleavage site probability 0.272 between residues 29 and 30; signal peptide 218496000124 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 218496000125 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 218496000126 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218496000127 Pyridine nucleotide-disulphide oxidoreductase Score = 221.0 E-value = 1.2e-63 218496000128 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Score = 91.6 E-value = 1.1e-24 218496000129 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 218496000130 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218496000131 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 218496000132 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 218496000133 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 218496000134 carboxyltransferase (CT) interaction site; other site 218496000135 biotinylation site [posttranslational modification]; other site 218496000136 Biotin-requiring enzyme Score = 73.7 E-value = 2.7e-19 218496000137 Biotin carboxylase C-terminal domain Score = 180.6 E-value = 1.8e-51 218496000138 Carbamoyl-phosphate synthase L chain, ATP binding domain Score = 301.7 E-value = 6.5e-88 218496000139 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 218496000140 Carbamoyl-phosphate synthase L chain, N-terminal domain Score = 149.0 E-value = 6e-42 218496000141 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.972 between residues 25 and 26; signal peptide 218496000142 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 7-29, 33-55, 68-90 and 101-123 218496000143 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 22-44 218496000144 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 218496000145 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 218496000146 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 218496000147 Carboxyl transferase domain Score = 893.4 E-value = 4.8e-266 218496000148 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 218496000149 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 218496000150 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 218496000151 Biotin/lipoate A/B protein ligase family Score = 84.2 E-value = 1.9e-22 218496000152 Biotin protein ligase C terminal domain Score = 41.4 E-value = 1.4e-09 218496000153 GtrA-like protein; Region: GtrA; cl00971 218496000154 GtrA-like protein Score = 36.2 E-value = 5.2e-08 218496000155 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 10-30, 51-73 and 83-105 218496000156 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 218496000157 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 218496000158 ATP-grasp domain Score = 56.7 E-value = 3.6e-14 218496000159 AIR carboxylase; Region: AIRC; cl00310 218496000160 AIR carboxylase Score = 236.9 E-value = 2e-68 218496000161 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 12-34, 38-55, 68-90 and 100-122 218496000162 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 218496000163 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 218496000164 NADP binding site [chemical binding]; other site 218496000165 active site 218496000166 putative substrate binding site [chemical binding]; other site 218496000167 RmlD substrate binding domain Score = 183.5 E-value = 2.3e-52 218496000168 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 218496000169 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 218496000170 NAD binding site [chemical binding]; other site 218496000171 substrate binding site [chemical binding]; other site 218496000172 homodimer interface [polypeptide binding]; other site 218496000173 active site 218496000174 NAD dependent epimerase/dehydratase family Score = 526.7 E-value = 1.1e-155 218496000175 PS00061 Short-chain dehydrogenases/reductases family signature. 218496000176 Cupin domain; Region: Cupin_2; cl09118 218496000177 dTDP-4-dehydrorhamnose 3,5-epimerase Score = 241.2 E-value = 1e-69 218496000178 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 218496000179 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 218496000180 substrate binding site [chemical binding]; other site 218496000181 tetramer interface [polypeptide binding]; other site 218496000182 Nucleotidyl transferase Score = 311.9 E-value = 5.3e-91 218496000183 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 218496000184 Probable Catalytic site [active] 218496000185 metal binding site [ion binding]; metal-binding site 218496000186 Glycosyl transferase Score = 72.8 E-value = 5e-19 218496000187 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 218496000188 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 218496000189 Walker A/P-loop; other site 218496000190 ATP binding site [chemical binding]; other site 218496000191 Q-loop/lid; other site 218496000192 ABC transporter signature motif; other site 218496000193 Walker B; other site 218496000194 D-loop; other site 218496000195 H-loop/switch region; other site 218496000196 ABC transporter Score = 129.9 E-value = 3.3e-36 218496000197 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000198 ABC-2 type transporter; Region: ABC2_membrane; cl11417 218496000199 ABC-2 type transporter Score = 151.4 E-value = 1.1e-42 218496000200 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 51-73, 88-110, 131-153, 168-190, 197-216 and 264-283 218496000201 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 218496000202 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 218496000203 Probable Catalytic site [active] 218496000204 Glycosyl transferase Score = 115.3 E-value = 8.3e-32 218496000205 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 218496000206 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 4-21, 33-55 and 59-81 218496000207 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 218496000208 Ligand binding site [chemical binding]; other site 218496000209 Putative Catalytic site [active] 218496000210 DXD motif; other site 218496000211 Glycosyl transferase Score = 75.8 E-value = 6.5e-20 218496000212 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.978) with cleavage site probability 0.865 between residues 60 and 61; signal peptide 218496000213 Predicted membrane protein (DUF2142); Region: DUF2142; cl01937 218496000214 12 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 37-59, 168-190, 197-214, 219-238, 250-272, 292-314, 326-348, 363-382, 387-409, 419-441, 448-470 and 528-550 218496000215 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 2-19 218496000216 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 33-55, 59-81, 94-114 and 124-146 218496000217 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.996 between residues 26 and 27; signal peptide 218496000218 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.992) with cleavage site probability 0.533 between residues 49 and 50; signal peptide 218496000219 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 15-33, 38-60, 75-97 and 104-126 218496000220 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.706) with cleavage site probability 0.437 between residues 35 and 36; signal peptide 218496000221 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 13-35, 40-59 and 72-94 218496000222 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.947 between residues 26 and 27; signal peptide 218496000223 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 7-26 218496000224 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.402 between residues 34 and 35; signal peptide 218496000225 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 12-34, 38-55, 68-90 and 100-119 218496000226 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.702) with cleavage site probability 0.385 between residues 25 and 26; signal peptide 218496000227 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 218496000228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 218496000229 dimer interface [polypeptide binding]; other site 218496000230 phosphorylation site [posttranslational modification] 218496000231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218496000232 ATP binding site [chemical binding]; other site 218496000233 G-X-G motif; other site 218496000234 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Score = 132.6 E-value = 5.2e-37 218496000235 His Kinase A (phosphoacceptor) domain Score = 68.2 E-value = 1.2e-17 218496000236 HAMP domain Score = 46.4 E-value = 4.5e-11 218496000237 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 5-24 and 148-170 218496000238 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 218496000239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 218496000240 active site 218496000241 phosphorylation site [posttranslational modification] 218496000242 intermolecular recognition site; other site 218496000243 dimerization interface [polypeptide binding]; other site 218496000244 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 218496000245 DNA binding site [nucleotide binding] 218496000246 Transcriptional regulatory protein, C terminal Score = 88.7 E-value = 8.6e-24 218496000247 Response regulator receiver domain Score = 141.1 E-value = 1.4e-39 218496000248 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 218496000249 DNA-binding site [nucleotide binding]; DNA binding site 218496000250 RNA-binding motif; other site 218496000251 'Cold-shock' DNA-binding domain Score = 23.9 E-value = 1.1e-05 218496000252 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 218496000253 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 218496000254 P-loop; other site 218496000255 Magnesium ion binding site [ion binding]; other site 218496000256 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 218496000257 Magnesium ion binding site [ion binding]; other site 218496000258 ParA family ATPase Score = 119.9 E-value = 3.4e-33 218496000259 prephenate dehydrogenase; Validated; Region: PRK06545 218496000260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218496000261 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH) enzyme that catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; Region: ACT_PDH-BS-like; cd04889 218496000262 Prephenate dehydrogenase Score = 124.4 E-value = 1.5e-34 218496000263 ACT domain Score = 19.1 E-value = 4.5e-05 218496000264 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 218496000265 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 218496000266 Active site [active] 218496000267 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 218496000268 CMP-binding site; other site 218496000269 The sites determining sugar specificity; other site 218496000270 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 218496000271 G1 box; other site 218496000272 GTP/Mg2+ binding site [chemical binding]; other site 218496000273 Switch I region; other site 218496000274 G2 box; other site 218496000275 Switch II region; other site 218496000276 G3 box; other site 218496000277 G4 box; other site 218496000278 G5 box; other site 218496000279 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 218496000280 G1 box; other site 218496000281 GTP/Mg2+ binding site [chemical binding]; other site 218496000282 Switch I region; other site 218496000283 G2 box; other site 218496000284 G3 box; other site 218496000285 Switch II region; other site 218496000286 G4 box; other site 218496000287 G5 box; other site 218496000288 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000289 Cytidylate kinase Score = 66.2 E-value = 4.8e-17 218496000290 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000291 GTPase of unknown function Score = 158.0 E-value = 1.2e-44 218496000292 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000293 chorismate binding enzyme; Region: Chorismate_bind; cl10555 218496000294 chorismate binding enzyme Score = 42.5 E-value = 1.2e-18 218496000295 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 218496000296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 218496000297 ubiE/COQ5 methyltransferase family Score = 136.3 E-value = 3.8e-38 218496000298 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 218496000299 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 218496000300 substrate binding pocket [chemical binding]; other site 218496000301 chain length determination region; other site 218496000302 substrate-Mg2+ binding site; other site 218496000303 catalytic residues [active] 218496000304 aspartate-rich region 1; other site 218496000305 active site lid residues [active] 218496000306 aspartate-rich region 2; other site 218496000307 Polyprenyl synthetase Score = 137.2 E-value = 2.2e-38 218496000308 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000309 PS00444 Polyprenyl synthetases signature 2. 218496000310 hypothetical protein; Provisional; Region: PRK09897 218496000311 ferredoxin-NADP+ reductase; Region: PLN02852 218496000312 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.630 between residues 26 and 27; signal peptide 218496000313 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 218496000314 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 218496000315 intersubunit interface [polypeptide binding]; other site 218496000316 Periplasmic binding protein Score = 83.8 E-value = 2.5e-22 218496000317 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218496000318 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.630 between residues 26 and 27; signal peptide 218496000319 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 218496000320 intersubunit interface [polypeptide binding]; other site 218496000321 Periplasmic binding protein Score = 81.2 E-value = 1.5e-21 218496000322 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218496000323 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 218496000324 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 218496000325 Walker A/P-loop; other site 218496000326 ATP binding site [chemical binding]; other site 218496000327 Q-loop/lid; other site 218496000328 ABC transporter signature motif; other site 218496000329 Walker B; other site 218496000330 D-loop; other site 218496000331 H-loop/switch region; other site 218496000332 ABC transporter Score = 172.0 E-value = 6.8e-49 218496000333 PS00211 ABC transporters family signature. 218496000334 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000335 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.829) with cleavage site probability 0.374 between residues 44 and 45; signal peptide 218496000336 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 218496000337 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 218496000338 ABC-ATPase subunit interface; other site 218496000339 dimer interface [polypeptide binding]; other site 218496000340 putative PBP binding regions; other site 218496000341 FecCD transport family Score = 267.8 E-value = 9.9e-78 218496000342 8 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 21-43, 70-92, 105-124, 128-150, 206-223, 251-273, 280-302 and 312-334 218496000343 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.836) with cleavage site probability 0.222 between residues 41 and 42; signal peptide 218496000344 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 218496000345 ABC-ATPase subunit interface; other site 218496000346 dimer interface [polypeptide binding]; other site 218496000347 putative PBP binding regions; other site 218496000348 FecCD transport family Score = 223.4 E-value = 2.3e-64 218496000349 9 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 5-27, 56-78, 88-110, 115-137, 142-164, 189-211, 231-253, 266-285 and 295-314 218496000350 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218496000351 dimerization interface [polypeptide binding]; other site 218496000352 putative DNA binding site [nucleotide binding]; other site 218496000353 putative Zn2+ binding site [ion binding]; other site 218496000354 Bacterial regulatory protein, arsR family Score = 84.2 E-value = 1.9e-22 218496000355 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 218496000356 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 218496000357 active site 218496000358 HIGH motif; other site 218496000359 KMSKS motif; other site 218496000360 tRNA synthetases class I (K) Score = 364.7 E-value = 7e-107 218496000361 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218496000362 Pantoate-beta-alanine ligase; Region: PanC; cd00560 218496000363 active site 218496000364 ATP-binding site [chemical binding]; other site 218496000365 pantoate-binding site; other site 218496000366 HXXH motif; other site 218496000367 Pantoate-beta-alanine ligase Score = 171.0 E-value = 1.4e-48 218496000368 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 218496000369 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 218496000370 putative active site [active] 218496000371 catalytic site [active] 218496000372 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 218496000373 putative active site [active] 218496000374 catalytic site [active] 218496000375 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 5-27 and 34-56 218496000376 Phospholipase D. Active site motif Score = 27.9 E-value = 1.7e-05 218496000377 Phospholipase D. Active site motif Score = 28.7 E-value = 9.3e-06 218496000378 Clp protease ATP binding subunit; Region: clpC; CHL00095 218496000379 Clp amino terminal domain; Region: Clp_N; pfam02861 218496000380 Clp amino terminal domain; Region: Clp_N; pfam02861 218496000381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 218496000382 Walker A motif; other site 218496000383 ATP binding site [chemical binding]; other site 218496000384 Walker B motif; other site 218496000385 arginine finger; other site 218496000386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 218496000387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 218496000388 Walker A motif; other site 218496000389 ATP binding site [chemical binding]; other site 218496000390 Walker B motif; other site 218496000391 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 218496000392 Clp amino terminal domain Score = 69.5 E-value = 5e-18 218496000393 Clp amino terminal domain Score = 74.2 E-value = 1.9e-19 218496000394 ATPase family associated with various cellular activities (AAA) Score = 44.1 E-value = 2.3e-10 218496000395 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000396 ATPase family associated with various cellular activities (AAA) Score = 15.1 E-value = 5.8e-06 218496000397 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000398 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 218496000399 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 218496000400 dimer interface [polypeptide binding]; other site 218496000401 tetramer interface [polypeptide binding]; other site 218496000402 PYR/PP interface [polypeptide binding]; other site 218496000403 TPP binding site [chemical binding]; other site 218496000404 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 218496000405 TPP-binding site; other site 218496000406 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Score = -42.9 E-value = 5.4e-05 218496000407 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.820 between residues 46 and 47; signal peptide 218496000408 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 12-29 218496000409 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.204 between residues 49 and 50; signal peptide 218496000410 UbiA prenyltransferase family; Region: UbiA; cl00337 218496000411 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 218496000412 9 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 13-35, 50-72, 93-115, 130-152, 159-181, 186-205, 225-247, 251-273 and 280-302 218496000413 UbiA prenyltransferase family Score = 64.0 E-value = 2.3e-16 218496000414 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 218496000415 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 218496000416 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 218496000417 RPB10 interaction site [polypeptide binding]; other site 218496000418 RPB1 interaction site [polypeptide binding]; other site 218496000419 RPB11 interaction site [polypeptide binding]; other site 218496000420 RPB3 interaction site [polypeptide binding]; other site 218496000421 RPB12 interaction site [polypeptide binding]; other site 218496000422 RNA polymerase beta subunit Score = 78.2 E-value = 1.2e-20 218496000423 RNA polymerase Rpb2, domain 2 Score = 48.6 E-value = 1e-11 218496000424 RNA polymerase Rpb2, domain 3 Score = 145.8 E-value = 5.4e-41 218496000425 RNA polymerase Rpb2, domain 6 Score = 688.8 E-value = 1.9e-204 218496000426 PS01166 RNA polymerases beta chain signature. 218496000427 RNA polymerase Rpb2, domain 7 Score = 170.3 E-value = 2.2e-48 218496000428 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 218496000429 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 218496000430 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 218496000431 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 218496000432 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 218496000433 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 218496000434 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 218496000435 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 218496000436 G-loop; other site 218496000437 DNA binding site [nucleotide binding] 218496000438 RNA polymerase Rpb1, domain 2 Score = 282.9 E-value = 2.9e-82 218496000439 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 218496000440 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 218496000441 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 218496000442 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 218496000443 Phospholipase/Carboxylesterase Score = 19.9 E-value = 6.7e-10 218496000444 Phospholipase/Carboxylesterase Score = 26.2 E-value = 2.4e-07 218496000445 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 218496000446 oligomerisation interface [polypeptide binding]; other site 218496000447 mobile loop; other site 218496000448 roof hairpin; other site 218496000449 Chaperonin 10 Kd subunit Score = 189.8 E-value = 3e-54 218496000450 PS00681 Chaperonins cpn10 signature. 218496000451 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 218496000452 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 218496000453 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 218496000454 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 218496000455 active site 218496000456 IMP dehydrogenase / GMP reductase Score = 647.7 E-value = 4.4e-192 218496000457 CBS domain Score = 55.5 E-value = 8.2e-14 218496000458 CBS domain Score = 45.7 E-value = 7.6e-11 218496000459 PS00487 IMP dehydrogenase / GMP reductase signature. 218496000460 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 218496000461 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 218496000462 active site 218496000463 IMP dehydrogenase / GMP reductase Score = 39.4 E-value = 1.7e-11 218496000464 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.976) with cleavage site probability 0.587 between residues 37 and 38; signal peptide 218496000465 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cl01321 218496000466 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 10-29 and 201-223 218496000467 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 218496000468 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 33-55, 76-98 and 108-130 218496000469 GMP synthase; Reviewed; Region: guaA; PRK00074 218496000470 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 218496000471 AMP/PPi binding site [chemical binding]; other site 218496000472 candidate oxyanion hole; other site 218496000473 catalytic triad [active] 218496000474 potential glutamine specificity residues [chemical binding]; other site 218496000475 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 218496000476 ATP Binding subdomain [chemical binding]; other site 218496000477 Ligand Binding sites [chemical binding]; other site 218496000478 Dimerization subdomain; other site 218496000479 Glutamine amidotransferase class-I Score = 137.2 E-value = 2.1e-38 218496000480 PS00442 Glutamine amidotransferases class-I active site. 218496000481 GMP synthase C terminal domain Score = 195.4 E-value = 6.1e-56 218496000482 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 218496000483 UvrD/REP helicase; Region: UvrD-helicase; cl14126 218496000484 UvrD/REP helicase Score = 607.9 E-value = 4.2e-180 218496000485 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000486 10 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 13-35, 68-90, 102-124, 134-153, 186-208, 218-240, 242-264, 284-306, 319-341 and 356-378 218496000487 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 218496000488 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 218496000489 active site 218496000490 substrate binding site [chemical binding]; other site 218496000491 cosubstrate binding site; other site 218496000492 catalytic site [active] 218496000493 Formyl transferase Score = 147.5 E-value = 1.7e-41 218496000494 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 218496000495 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 218496000496 purine monophosphate binding site [chemical binding]; other site 218496000497 dimer interface [polypeptide binding]; other site 218496000498 putative catalytic residues [active] 218496000499 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 218496000500 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 218496000501 MGS-like domain Score = 106.3 E-value = 4.1e-29 218496000502 AICARFT/IMPCHase bienzyme Score = 360.0 E-value = 1.8e-105 218496000503 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.620) with cleavage site probability 0.196 between residues 43 and 44; signal peptide 218496000504 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 9-31, 36-58, 65-87 and 92-111 218496000505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218496000506 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218496000507 putative substrate translocation pore; other site 218496000508 11 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 20-42, 55-72, 76-98, 111-133, 137-159, 180-199, 214-236, 243-260, 264-286, 298-320 and 324-346 218496000509 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 218496000510 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 218496000511 RNA binding site [nucleotide binding]; other site 218496000512 active site 218496000513 TruB family pseudouridylate synthase (N terminal domain) Score = 155.3 E-value = 7.4e-44 218496000514 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 218496000515 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 218496000516 active site 218496000517 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 218496000518 protein binding site [polypeptide binding]; other site 218496000519 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 218496000520 putative substrate binding region [chemical binding]; other site 218496000521 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 2-24, 107-129, 288-310 and 343-365 218496000522 Peptidase family M50 Score = 122.5 E-value = 5.6e-34 218496000523 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218496000524 PDZ domain (Also known as DHR or GLGF) Score = 11.3 E-value = 0.0056 218496000525 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 218496000526 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 218496000527 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 218496000528 1-deoxy-D-xylulose 5-phosphate reductoisomerase Score = 517.2 E-value = 8.4e-153 218496000529 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 218496000530 Protein phosphatase 2C; Region: PP2C; pfam00481 218496000531 Active site [active] 218496000532 Protein phosphatase 2C Score = -16.8 E-value = 2.9e-06 218496000533 Predicted ATPase [General function prediction only]; Region: COG4637 218496000534 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 218496000535 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 218496000536 putative active site [active] 218496000537 putative metal-binding site [ion binding]; other site 218496000538 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000539 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 5-22 and 32-54 218496000540 8 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 31-53, 68-90, 111-130, 145-167, 180-202, 242-264, 277-299 and 314-336 218496000541 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 22-44, 51-73 and 77-99 218496000542 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 218496000543 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 218496000544 Walker A/P-loop; other site 218496000545 ATP binding site [chemical binding]; other site 218496000546 Q-loop/lid; other site 218496000547 ABC transporter signature motif; other site 218496000548 Walker B; other site 218496000549 D-loop; other site 218496000550 H-loop/switch region; other site 218496000551 ABC transporter Score = 87.8 E-value = 1.5e-23 218496000552 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000553 PS00211 ABC transporters family signature. 218496000554 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.305 between residues 48 and 49; signal peptide 218496000555 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 20-42 and 77-99 218496000556 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 218496000557 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218496000558 DNA binding site [nucleotide binding] 218496000559 Int/Topo IB signature motif; other site 218496000560 active site 218496000561 Phage integrase family Score = 163.2 E-value = 3e-46 218496000562 Phage integrase, N-terminal SAM-like domain Score = 23.4 E-value = 0.00024 218496000563 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 218496000564 dimer interface [polypeptide binding]; other site 218496000565 ADP-ribose binding site [chemical binding]; other site 218496000566 active site 218496000567 nudix motif; other site 218496000568 metal binding site [ion binding]; metal-binding site 218496000569 NUDIX domain Score = 83.9 E-value = 2.3e-22 218496000570 CTP synthetase; Validated; Region: pyrG; PRK05380 218496000571 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 218496000572 Catalytic site [active] 218496000573 Active site [active] 218496000574 UTP binding site [chemical binding]; other site 218496000575 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 218496000576 active site 218496000577 putative oxyanion hole; other site 218496000578 catalytic triad [active] 218496000579 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000580 Glutamine amidotransferase class-I Score = 193.3 E-value = 2.7e-55 218496000581 PS00442 Glutamine amidotransferases class-I active site. 218496000582 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 7-29 218496000583 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 218496000584 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 218496000585 Walker A/P-loop; other site 218496000586 ATP binding site [chemical binding]; other site 218496000587 Q-loop/lid; other site 218496000588 Vegetative insecticide protein 3A N terminal; Region: Vip3A_N; pfam12495 218496000589 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 218496000590 ABC transporter signature motif; other site 218496000591 Walker B; other site 218496000592 D-loop; other site 218496000593 H-loop/switch region; other site 218496000594 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 218496000595 ATP-NAD kinase Score = 192.6 E-value = 4.5e-55 218496000596 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.943 between residues 43 and 44; signal peptide 218496000597 Putative Ig domain; Region: He_PIG; cl09256 218496000598 Putative Ig domain; Region: He_PIG; cl09256 218496000599 Putative Ig domain; Region: He_PIG; cl09256 218496000600 Putative Ig domain; Region: He_PIG; cl09256 218496000601 Putative Ig domain; Region: He_PIG; cl09256 218496000602 Putative Ig domain; Region: He_PIG; cl09256 218496000603 Putative Ig domain; Region: He_PIG; cl09256 218496000604 Putative Ig domain; Region: He_PIG; cl09256 218496000605 Putative Ig domain; Region: He_PIG; cl09256 218496000606 WisP family C-Terminal Region; Region: CCD; pfam07860 218496000607 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 13-35 218496000608 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 218496000609 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 218496000610 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 218496000611 Ribosomal protein L9, C-terminal domain Score = 72.5 E-value = 6.2e-19 218496000612 Ribosomal protein L9, N-terminal domain Score = 74.5 E-value = 1.5e-19 218496000613 PS00651 Ribosomal protein L9 signature. 218496000614 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 218496000615 Ribosomal protein S18 Score = 79.2 E-value = 5.8e-21 218496000616 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 218496000617 dimer interface [polypeptide binding]; other site 218496000618 ssDNA binding site [nucleotide binding]; other site 218496000619 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218496000620 Single-strand binding protein family Score = 117.9 E-value = 1.3e-32 218496000621 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 218496000622 Ribosomal protein S6 Score = 26.7 E-value = 7.9e-08 218496000623 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 218496000624 ATP binding site [chemical binding]; other site 218496000625 active site 218496000626 substrate binding site [chemical binding]; other site 218496000627 SAICAR synthetase Score = 194.1 E-value = 1.5e-55 218496000628 PS01058 SAICAR synthetase signature 2. 218496000629 naphthoate synthase; Validated; Region: PRK08321 218496000630 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 218496000631 substrate binding site [chemical binding]; other site 218496000632 oxyanion hole (OAH) forming residues; other site 218496000633 trimer interface [polypeptide binding]; other site 218496000634 Enoyl-CoA hydratase/isomerase family Score = 125.3 E-value = 7.9e-35 218496000635 PS00166 Enoyl-CoA hydratase/isomerase signature. 218496000636 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 218496000637 AMP-binding enzyme Score = 30.4 E-value = 1.5e-08 218496000638 AMP-binding enzyme Score = 44.7 E-value = 1.7e-12 218496000639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 218496000640 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 218496000641 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 218496000642 Iron dependent repressor, N-terminal DNA binding domain Score = 32.7 E-value = 5.9e-07 218496000643 Iron dependent repressor, metal binding and dimerisation domain Score = 104.2 E-value = 1.8e-28 218496000644 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 218496000645 Ribosomal L28 family Score = 75.1 E-value = 1e-19 218496000646 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 218496000647 Ribosomal protein L33 Score = 42.9 E-value = 5.2e-10 218496000648 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 218496000649 Ribosomal protein S14p/S29e Score = 114.0 E-value = 2e-31 218496000650 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 218496000651 IHF dimer interface [polypeptide binding]; other site 218496000652 IHF - DNA interface [nucleotide binding]; other site 218496000653 Bacterial DNA-binding protein Score = 97.6 E-value = 1.8e-26 218496000654 Predicted helix-turn-helix motif with score 1013.000, SD 2.64 at aa 8-29, sequence ELVAKVAETSGVSRATVNSVIE 218496000655 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.974) with cleavage site probability 0.443 between residues 34 and 35; signal peptide 218496000656 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 218496000657 16 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 7-29, 44-66, 79-101, 116-138, 145-162, 238-260, 287-309, 324-343, 350-372, 407-429, 449-471, 481-503, 524-546, 561-583, 596-618 and 645-667 218496000658 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 218496000659 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218496000660 ATP binding site [chemical binding]; other site 218496000661 putative Mg++ binding site [ion binding]; other site 218496000662 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218496000663 nucleotide binding region [chemical binding]; other site 218496000664 ATP-binding site [chemical binding]; other site 218496000665 SNF2 family N-terminal domain Score = -26.6 E-value = 2.3e-08 218496000666 Helicase conserved C-terminal domain Score = 52.2 E-value = 8.2e-13 218496000667 elongation factor Tu; Reviewed; Region: PRK00049 218496000668 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 218496000669 G1 box; other site 218496000670 GEF interaction site [polypeptide binding]; other site 218496000671 GTP/Mg2+ binding site [chemical binding]; other site 218496000672 Switch I region; other site 218496000673 G2 box; other site 218496000674 G3 box; other site 218496000675 Switch II region; other site 218496000676 G4 box; other site 218496000677 G5 box; other site 218496000678 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 218496000679 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 218496000680 Antibiotic Binding Site [chemical binding]; other site 218496000681 Elongation factor Tu GTP binding domain Score = 317.3 E-value = 1.2e-92 218496000682 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000683 PS00301 GTP-binding elongation factors signature. 218496000684 Elongation factor Tu domain 2 Score = 105.9 E-value = 5.4e-29 218496000685 Elongation factor Tu C-terminal domain Score = 190.4 E-value = 2e-54 218496000686 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 218496000687 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 218496000688 10 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 4-23, 103-125, 130-149, 154-173, 220-242, 263-285, 374-393, 400-419, 423-445 and 513-535 218496000689 Dolichyl-phosphate-mannose-protein mannosyltransferase Score = 3.2 E-value = 0.00012 218496000690 Phosphomannose isomerase type I; Region: PMI_typeI; pfam01238 218496000691 mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659 218496000692 Phosphomannose isomerase type I Score = 64.2 E-value = 2e-16 218496000693 Transcription factor WhiB; Region: Whib; pfam02467 218496000694 Transcription factor WhiB Score = 125.1 E-value = 8.9e-35 218496000695 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 218496000696 13 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 235-257, 320-342, 371-393, 400-419, 429-448, 455-472, 487-509, 516-535, 561-583, 588-610, 615-633, 640-662 and 805-827 218496000697 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.606 between residues 34 and 35; signal peptide 218496000698 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 7-29 218496000699 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 218496000700 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 218496000701 active site 218496000702 substrate binding site [chemical binding]; other site 218496000703 metal binding site [ion binding]; metal-binding site 218496000704 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I Score = 132.2 E-value = 6.9e-37 218496000705 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Score = 101.0 E-value = 1.7e-27 218496000706 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Score = 67.0 E-value = 2.8e-17 218496000707 Phosphoglucomutase/phosphomannomutase, C-terminal domain Score = 15.5 E-value = 0.0008 218496000708 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 218496000709 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 218496000710 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000711 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 218496000712 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 218496000713 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 218496000714 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218496000715 nucleotide binding region [chemical binding]; other site 218496000716 ATP-binding site [chemical binding]; other site 218496000717 SecA protein, amino terminal region Score = 855.6 E-value = 1.1e-254 218496000718 PS01312 Protein secA signatures. 218496000719 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.480 between residues 38 and 39; signal peptide 218496000720 SAF domain; Region: SAF; cl00555 218496000721 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 13-31 218496000722 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 218496000723 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 218496000724 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000725 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 30-52 and aa 131-153 218496000726 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 131-153 218496000727 glycine dehydrogenase; Provisional; Region: PRK05367 218496000728 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 218496000729 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218496000730 catalytic residue [active] 218496000731 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 218496000732 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218496000733 catalytic residue [active] 218496000734 Glycine cleavage system P-protein Score = 572.6 E-value = 1.8e-169 218496000735 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 218496000736 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.577 between residues 33 and 34; signal peptide 218496000737 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 218496000738 Bacterial extracellular solute-binding proteins, family 5 Score = 96.8 E-value = 3e-26 218496000739 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218496000740 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.787 between residues 33 and 34; signal peptide 218496000741 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 218496000742 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 218496000743 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 7-29 218496000744 Bacterial extracellular solute-binding proteins, family 5 Score = 94.3 E-value = 1.7e-25 218496000745 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218496000746 Cobalt transport protein; Region: CbiQ; cl00463 218496000747 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 39-61, 71-93 and 114-133 218496000748 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 218496000749 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 218496000750 Walker A/P-loop; other site 218496000751 ATP binding site [chemical binding]; other site 218496000752 Q-loop/lid; other site 218496000753 ABC transporter signature motif; other site 218496000754 Walker B; other site 218496000755 D-loop; other site 218496000756 H-loop/switch region; other site 218496000757 ABC transporter Score = 169.5 E-value = 3.9e-48 218496000758 PS00211 ABC transporters family signature. 218496000759 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000760 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 218496000761 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.824) with cleavage site probability 0.215 between residues 38 and 39; signal peptide 218496000762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 218496000763 dimer interface [polypeptide binding]; other site 218496000764 conserved gate region; other site 218496000765 putative PBP binding loops; other site 218496000766 ABC-ATPase subunit interface; other site 218496000767 7 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 10-32, 63-85, 100-122, 135-157, 172-194, 229-251 and 279-301 218496000768 Binding-protein-dependent transport systems inner membrane component Score = 40.2 E-value = 3.3e-09 218496000769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 218496000770 dimer interface [polypeptide binding]; other site 218496000771 conserved gate region; other site 218496000772 putative PBP binding loops; other site 218496000773 ABC-ATPase subunit interface; other site 218496000774 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 52-74, 121-143, 150-172, 177-199, 230-252 and 287-309 218496000775 Binding-protein-dependent transport systems inner membrane component Score = 20.6 E-value = 0.00061 218496000776 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 218496000777 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 218496000778 Walker A/P-loop; other site 218496000779 ATP binding site [chemical binding]; other site 218496000780 Q-loop/lid; other site 218496000781 ABC transporter signature motif; other site 218496000782 Walker B; other site 218496000783 D-loop; other site 218496000784 H-loop/switch region; other site 218496000785 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218496000786 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 218496000787 Walker A/P-loop; other site 218496000788 ATP binding site [chemical binding]; other site 218496000789 Q-loop/lid; other site 218496000790 ABC transporter signature motif; other site 218496000791 Walker B; other site 218496000792 D-loop; other site 218496000793 H-loop/switch region; other site 218496000794 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218496000795 ABC transporter Score = 178.0 E-value = 1.1e-50 218496000796 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000797 PS00211 ABC transporters family signature. 218496000798 ABC transporter Score = 191.4 E-value = 1e-54 218496000799 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000800 PS00211 ABC transporters family signature. 218496000801 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.707 between residues 36 and 37; signal peptide 218496000802 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 13-35, 39-61 and 233-255 218496000803 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 218496000804 23S rRNA interface [nucleotide binding]; other site 218496000805 L3 interface [polypeptide binding]; other site 218496000806 Ribosomal protein L13 Score = 225.7 E-value = 4.9e-65 218496000807 PS00783 Ribosomal protein L13 signature. 218496000808 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 218496000809 Ribosomal protein S9/S16 Score = 192.8 E-value = 3.7e-55 218496000810 PS00360 Ribosomal protein S9 signature. 218496000811 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 218496000812 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 218496000813 active site 218496000814 substrate binding site [chemical binding]; other site 218496000815 metal binding site [ion binding]; metal-binding site 218496000816 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I Score = 155.2 E-value = 7.9e-44 218496000817 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Score = 80.7 E-value = 2.2e-21 218496000818 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Score = 86.9 E-value = 3e-23 218496000819 Phosphoglucomutase/phosphomannomutase, C-terminal domain Score = 17.6 E-value = 0.00048 218496000820 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 218496000821 ATP-binding site [chemical binding]; other site 218496000822 CoA-binding site [chemical binding]; other site 218496000823 Mg2+-binding site [ion binding]; other site 218496000824 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000825 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.891 between residues 45 and 46 218496000826 WisP family N-Terminal Region; Region: WND; pfam07861 218496000827 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 21-43, 504-526, 562-584 and 635-657 218496000828 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 218496000829 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 218496000830 glutaminase active site [active] 218496000831 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 218496000832 dimer interface [polypeptide binding]; other site 218496000833 active site 218496000834 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 218496000835 dimer interface [polypeptide binding]; other site 218496000836 active site 218496000837 PS00443 Glutamine amidotransferases class-II active site. 218496000838 Glutamine amidotransferases class-II Score = 221.0 E-value = 1.2e-63 218496000839 SIS domain Score = 136.8 E-value = 2.7e-38 218496000840 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218496000841 SIS domain Score = 119.4 E-value = 4.6e-33 218496000842 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 218496000843 GHMP kinases putative ATP-binding protein Score = 49.3 E-value = 6e-12 218496000844 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 218496000845 diiron binding motif [ion binding]; other site 218496000846 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 218496000847 5 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 133-155, 160-182, 282-304, 309-331 and 344-363 218496000848 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.819 between residues 42 and 43 218496000849 WisP family N-Terminal Region; Region: WND; pfam07861 218496000850 Putative Ig domain; Region: He_PIG; cl09256 218496000851 Putative Ig domain; Region: He_PIG; cl09256 218496000852 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 588-610, 629-651 and 683-705 218496000853 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.981) with cleavage site probability 0.595 between residues 49 and 50; signal peptide 218496000854 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218496000855 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 218496000856 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 218496000857 Walker A/P-loop; other site 218496000858 ATP binding site [chemical binding]; other site 218496000859 Q-loop/lid; other site 218496000860 ABC transporter signature motif; other site 218496000861 Walker B; other site 218496000862 D-loop; other site 218496000863 H-loop/switch region; other site 218496000864 ABC transporter Score = 201.4 E-value = 9.6e-58 218496000865 PS00211 ABC transporters family signature. 218496000866 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000867 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 21-43, 58-80, 133-155, 160-179, 240-262 and 272-293 218496000868 ABC transporter transmembrane region Score = -19.6 E-value = 0.0025 218496000869 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 218496000870 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 218496000871 Walker A/P-loop; other site 218496000872 ATP binding site [chemical binding]; other site 218496000873 Q-loop/lid; other site 218496000874 ABC transporter signature motif; other site 218496000875 Walker B; other site 218496000876 D-loop; other site 218496000877 H-loop/switch region; other site 218496000878 ABC transporter Score = 156.8 E-value = 2.6e-44 218496000879 PS00211 ABC transporters family signature. 218496000880 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000881 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 56-78, 98-120, 169-191, 195-217, 284-306 and 326-348 218496000882 ABC transporter transmembrane region Score = 37.9 E-value = 1.7e-08 218496000883 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.866) with cleavage site probability 0.502 between residues 52 and 53; signal peptide 218496000884 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 29-51 and 56-78 218496000885 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 218496000886 active site 218496000887 ATP binding site [chemical binding]; other site 218496000888 substrate binding site [chemical binding]; other site 218496000889 activation loop (A-loop); other site 218496000890 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 305-327 218496000891 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 218496000892 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 218496000893 G1 box; other site 218496000894 putative GEF interaction site [polypeptide binding]; other site 218496000895 GTP/Mg2+ binding site [chemical binding]; other site 218496000896 Switch I region; other site 218496000897 G2 box; other site 218496000898 G3 box; other site 218496000899 Switch II region; other site 218496000900 G4 box; other site 218496000901 G5 box; other site 218496000902 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 218496000903 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 218496000904 Elongation factor Tu GTP binding domain Score = 223.5 E-value = 2.2e-64 218496000905 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000906 PS00301 GTP-binding elongation factors signature. 218496000907 Elongation factor Tu domain 2 Score = 48.2 E-value = 1.3e-11 218496000908 Elongation factor G C-terminus Score = 75.4 E-value = 8.5e-20 218496000909 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 218496000910 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 218496000911 4'-phosphopantetheinyl transferase superfamily Score = 48.8 E-value = 8.6e-12 218496000912 Uncharacterised P-loop hydrolase UPF0079 Score = 111.1 E-value = 1.5e-30 218496000913 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000914 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 218496000915 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 218496000916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218496000917 Coenzyme A binding pocket [chemical binding]; other site 218496000918 Glycoprotease family Score = 18.0 E-value = 1.9e-05 218496000919 Acetyltransferase (GNAT) family Score = 86.8 E-value = 3.2e-23 218496000920 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 218496000921 UGMP family protein; Validated; Region: PRK09604 218496000922 Glycoprotease family Score = 376.6 E-value = 1.7e-110 218496000923 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 218496000924 Ligand Binding Site [chemical binding]; other site 218496000925 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 218496000926 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 218496000927 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 218496000928 Phosphoribosyl transferase domain Score = 63.3 E-value = 3.6e-16 218496000929 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 218496000930 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.907) with cleavage site probability 0.640 between residues 32 and 33; signal peptide 218496000931 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 218496000932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 218496000933 Walker A motif; other site 218496000934 ATP binding site [chemical binding]; other site 218496000935 Walker B motif; other site 218496000936 arginine finger; other site 218496000937 Peptidase family M41; Region: Peptidase_M41; pfam01434 218496000938 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 10-27 and 109-131 218496000939 ATPase family associated with various cellular activities (AAA) Score = 328.5 E-value = 5.6e-96 218496000940 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000941 PS00674 AAA-protein family signature. 218496000942 Peptidase family M41 Score = 336.5 E-value = 2.1e-98 218496000943 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 218496000944 active site 218496000945 GTP cyclohydrolase I Score = 46.7 E-value = 3.8e-11 218496000946 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 218496000947 dihydropteroate synthase; Region: DHPS; TIGR01496 218496000948 substrate binding pocket [chemical binding]; other site 218496000949 dimer interface [polypeptide binding]; other site 218496000950 inhibitor binding site; inhibition site 218496000951 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 218496000952 active site 218496000953 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 218496000954 catalytic center binding site [active] 218496000955 ATP binding site [chemical binding]; other site 218496000956 PS00792 Dihydropteroate synthase signature 1. 218496000957 Pterin binding enzyme Score = 325.9 E-value = 3.3e-95 218496000958 PS00793 Dihydropteroate synthase signature 2. 218496000959 Dihydroneopterin aldolase Score = 59.2 E-value = 6.1e-15 218496000960 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) Score = 100.9 E-value = 1.7e-27 218496000961 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.468 between residues 27 and 28; signal peptide 218496000962 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 218496000963 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 5-24, 34-56, 77-99 and 114-136 218496000964 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 218496000965 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 218496000966 Walker A/P-loop; other site 218496000967 ATP binding site [chemical binding]; other site 218496000968 Q-loop/lid; other site 218496000969 ABC transporter signature motif; other site 218496000970 Walker B; other site 218496000971 D-loop; other site 218496000972 H-loop/switch region; other site 218496000973 ABC transporter Score = 108.4 E-value = 9.9e-30 218496000974 PS00017 ATP/GTP-binding site motif A (P-loop). 218496000975 PS00211 ABC transporters family signature. 218496000976 5 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 23-45, 75-97, 112-134, 146-168 and 194-216 218496000977 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 218496000978 Uracil DNA glycosylase superfamily Score = 170.1 E-value = 2.7e-48 218496000979 PS00130 Uracil-DNA glycosylase signature. 218496000980 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 218496000981 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 218496000982 active site 218496000983 Riboflavin kinase; Region: Flavokinase; pfam01687 218496000984 Riboflavin kinase / FAD synthetase Score = 125.2 E-value = 8.4e-35 218496000985 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.992 between residues 30 and 31; signal peptide 218496000986 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 10-32 218496000987 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 4-21, 77-99, 152-174 and 179-201 218496000988 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.981) with cleavage site probability 0.862 between residues 45 and 46; signal peptide 218496000989 5 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 7-38, 53-70, 83-105, 125-147 and 159-181 218496000990 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 70-92, 97-119, 126-145 and 155-177 218496000991 Ferredoxin [Energy production and conversion]; Region: COG1146 218496000992 4Fe-4S binding domain; Region: Fer4; cl02805 218496000993 4Fe-4S binding domain Score = 38.9 E-value = 8e-09 218496000994 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218496000995 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; cl02342 218496000996 9 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 36-58, 110-132, 137-159, 166-200, 215-234, 254-276, 321-343, 350-372 and 392-414 218496000997 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.405 between residues 23 and 24; signal peptide 218496000998 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 12-34 and 195-217 218496000999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 218496001000 S-adenosylmethionine binding site [chemical binding]; other site 218496001001 O-methyltransferase Score = -50.0 E-value = 1.3e-08 218496001002 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.889) with cleavage site probability 0.511 between residues 31 and 32; signal peptide 218496001003 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 11-30 218496001004 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.780 between residues 28 and 29; signal peptide 218496001005 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 7-29 and 111-133 218496001006 5 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 15-30, 64-86, 101-123, 169-191 and 201-223 218496001007 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 218496001008 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 218496001009 hinge; other site 218496001010 active site 218496001011 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) Score = 326.9 E-value = 1.7e-95 218496001012 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 218496001013 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 218496001014 generic binding surface II; other site 218496001015 ssDNA binding site; other site 218496001016 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218496001017 ATP binding site [chemical binding]; other site 218496001018 putative Mg++ binding site [ion binding]; other site 218496001019 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218496001020 nucleotide binding region [chemical binding]; other site 218496001021 ATP-binding site [chemical binding]; other site 218496001022 OB-fold nucleic acid binding domain Score = 47.9 E-value = 1.6e-11 218496001023 DEAD/DEAH box helicase Score = 98.8 E-value = 7.8e-27 218496001024 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001025 Helicase conserved C-terminal domain Score = 76.5 E-value = 3.9e-20 218496001026 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218496001027 active site 218496001028 nucleotide binding site [chemical binding]; other site 218496001029 HIGH motif; other site 218496001030 KMSKS motif; other site 218496001031 Cytidylyltransferase Score = 56.8 E-value = 3.4e-14 218496001032 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_5; cd05830 218496001033 active site 218496001034 catalytic site [active] 218496001035 Sortase family Score = 54.3 E-value = 1.9e-13 218496001036 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 27-49 218496001037 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 218496001038 Ribosomal L32p protein family Score = 17.6 E-value = 0.00057 218496001039 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 218496001040 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 218496001041 dimerization interface [polypeptide binding]; other site 218496001042 active site 218496001043 metal binding site [ion binding]; metal-binding site 218496001044 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cl00054 218496001045 RNase3 domain Score = 160.6 E-value = 1.8e-45 218496001046 PS00517 Ribonuclease III family signature. 218496001047 Double-stranded RNA binding motif Score = 71.7 E-value = 1.1e-18 218496001048 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 218496001049 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 218496001050 dimerization interface [polypeptide binding]; other site 218496001051 ligand binding site [chemical binding]; other site 218496001052 Receptor family ligand binding region Score = -7.8 E-value = 4.8e-05 218496001053 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 218496001054 TM-ABC transporter signature motif; other site 218496001055 Branched-chain amino acid transport system / permease component Score = 127.1 E-value = 2.3e-35 218496001056 9 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 33-55, 60-82, 92-114, 127-149, 169-191, 224-246, 251-273, 280-297 and 307-329 218496001057 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 218496001058 TM-ABC transporter signature motif; other site 218496001059 9 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 21-43, 53-72, 79-97, 107-129, 136-158, 188-207, 238-260, 275-297 and 310-327 218496001060 Branched-chain amino acid transport system / permease component Score = 94.8 E-value = 1.2e-25 218496001061 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 218496001062 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 218496001063 Walker A/P-loop; other site 218496001064 ATP binding site [chemical binding]; other site 218496001065 Q-loop/lid; other site 218496001066 ABC transporter signature motif; other site 218496001067 Walker B; other site 218496001068 D-loop; other site 218496001069 H-loop/switch region; other site 218496001070 ABC transporter Score = 197.7 E-value = 1.3e-56 218496001071 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001072 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 218496001073 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 218496001074 Walker A/P-loop; other site 218496001075 ATP binding site [chemical binding]; other site 218496001076 Q-loop/lid; other site 218496001077 ABC transporter signature motif; other site 218496001078 Walker B; other site 218496001079 D-loop; other site 218496001080 H-loop/switch region; other site 218496001081 ABC transporter Score = 187.2 E-value = 1.9e-53 218496001082 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001083 PS00211 ABC transporters family signature. 218496001084 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 218496001085 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 218496001086 P loop; other site 218496001087 GTP binding site [chemical binding]; other site 218496001088 SRP54-type protein, GTPase domain Score = 329.8 E-value = 2.2e-96 218496001089 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001090 PS00300 SRP54-type proteins GTP-binding domain signature. 218496001091 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 218496001092 Ribosomal protein S10p/S20e Score = 176.1 E-value = 4e-50 218496001093 PS00361 Ribosomal protein S10 signature. 218496001094 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 218496001095 Ribosomal protein L3 Score = 213.6 E-value = 2.2e-61 218496001096 PS00474 Ribosomal protein L3 signature. 218496001097 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 218496001098 Ribosomal protein L4/L1 family Score = 159.9 E-value = 3e-45 218496001099 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 218496001100 Ribosomal protein L23 Score = 107.4 E-value = 1.9e-29 218496001101 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00050 Ribosomal protein L23 signature. 218496001102 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 218496001103 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 218496001104 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 218496001105 Ribosomal Proteins L2, RNA binding domain Score = 162.1 E-value = 6.5e-46 218496001106 Ribosomal Proteins L2, C-terminal domain Score = 286.9 E-value = 1.8e-83 218496001107 PS00467 Ribosomal protein L2 signature. 218496001108 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 218496001109 Ribosomal protein S19 Score = 176.2 E-value = 3.8e-50 218496001110 PS00323 Ribosomal protein S19 signature. 218496001111 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 218496001112 putative translocon binding site; other site 218496001113 protein-rRNA interface [nucleotide binding]; other site 218496001114 Ribosomal protein L22p/L17e Score = 127.3 E-value = 1.9e-35 218496001115 PS00464 Ribosomal protein L22 signature. 218496001116 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 218496001117 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 218496001118 G-X-X-G motif; other site 218496001119 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 218496001120 Ribosomal protein S3, N-terminal domain Score = 98.0 E-value = 1.3e-26 218496001121 KH domain Score = 20.6 E-value = 0.00091 218496001122 Ribosomal protein S3, C-terminal domain Score = 147.0 E-value = 2.3e-41 218496001123 PS00548 Ribosomal protein S3 signature. 218496001124 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 218496001125 23S rRNA interface [nucleotide binding]; other site 218496001126 5S rRNA interface [nucleotide binding]; other site 218496001127 putative antibiotic binding site [chemical binding]; other site 218496001128 L25 interface [polypeptide binding]; other site 218496001129 L27 interface [polypeptide binding]; other site 218496001130 Ribosomal protein L16 Score = 246.8 E-value = 2.1e-71 218496001131 PS00701 Ribosomal protein L16 signature 2. 218496001132 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 218496001133 23S rRNA interface [nucleotide binding]; other site 218496001134 putative translocon interaction site; other site 218496001135 signal recognition particle (SRP54) interaction site; other site 218496001136 L23 interface [polypeptide binding]; other site 218496001137 trigger factor interaction site; other site 218496001138 Ribosomal L29 protein Score = 75.4 E-value = 8.4e-20 218496001139 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 218496001140 Ribosomal protein S17 Score = 113.0 E-value = 4e-31 218496001141 PS00056 Ribosomal protein S17 signature. 218496001142 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 218496001143 Ribosomal protein L14p/L23e Score = 260.6 E-value = 1.4e-75 218496001144 PS00049 Ribosomal protein L14 signature. 218496001145 KOW motif; Region: KOW; cl00354 218496001146 PS00052 Ribosomal protein S7 signature. 218496001147 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 218496001148 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 218496001149 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 218496001150 Ribosomal protein L5 Score = 98.0 E-value = 1.3e-26 218496001151 ribosomal L5P family C-terminus Score = 177.5 E-value = 1.5e-50 218496001152 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 218496001153 Ribosomal protein S8 Score = 214.2 E-value = 1.4e-61 218496001154 PS00053 Ribosomal protein S8 signature. 218496001155 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 218496001156 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 218496001157 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 218496001158 Ribosomal protein L6 Score = 63.0 E-value = 4.5e-16 218496001159 Ribosomal protein L6 Score = 85.9 E-value = 5.6e-23 218496001160 PS00525 Ribosomal protein L6 signature 1. 218496001161 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 218496001162 5S rRNA interface [nucleotide binding]; other site 218496001163 L27 interface [polypeptide binding]; other site 218496001164 23S rRNA interface [nucleotide binding]; other site 218496001165 L5 interface [polypeptide binding]; other site 218496001166 Ribosomal L18p/L5e family Score = 162.3 E-value = 5.9e-46 218496001167 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 218496001168 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 218496001169 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 218496001170 Ribosomal protein S5, N-terminal domain Score = 136.6 E-value = 3.2e-38 218496001171 PS00585 Ribosomal protein S5 signature. 218496001172 Ribosomal protein S5, C-terminal domain Score = 126.0 E-value = 4.8e-35 218496001173 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 218496001174 Ribosomal protein L15 amino terminal region Score = 123.2 E-value = 3.4e-34 218496001175 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001176 Ribosomal protein L15 Score = 29.2 E-value = 7e-06 218496001177 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 218496001178 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.891) with cleavage site probability 0.399 between residues 48 and 49; signal peptide 218496001179 SecY translocase; Region: SecY; pfam00344 218496001180 9 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 19-41, 74-96, 116-138, 158-180, 187-209, 214-236, 257-279, 320-342 and 381-403 218496001181 eubacterial secY protein Score = 548.2 E-value = 3.8e-162 218496001182 PS00755 Protein secY signature 1. 218496001183 PS00756 Protein secY signature 2. 218496001184 adenylate kinase; Reviewed; Region: adk; PRK00279 218496001185 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 218496001186 AMP-binding site [chemical binding]; other site 218496001187 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 218496001188 Adenylate kinase Score = 139.0 E-value = 5.8e-39 218496001189 PS00113 Adenylate kinase signature. 218496001190 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 218496001191 Aminotransferase class IV; Region: Aminotran_4; pfam01063 218496001192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218496001193 catalytic residue [active] 218496001194 Aminotransferase class IV Score = 23.8 E-value = 2.5e-12 218496001195 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 218496001196 rRNA binding site [nucleotide binding]; other site 218496001197 predicted 30S ribosome binding site; other site 218496001198 S1 RNA binding domain Score = 34.6 E-value = 1.6e-07 218496001199 PS00215 Mitochondrial energy transfer proteins signature. 218496001200 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 218496001201 Ribosomal protein L36 Score = 62.1 E-value = 8.6e-16 218496001202 PS00828 Ribosomal protein L36 signature. 218496001203 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 218496001204 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 218496001205 Ribosomal protein S13/S18 Score = 166.5 E-value = 3.1e-47 218496001206 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 218496001207 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 218496001208 Ribosomal protein S11 Score = 226.0 E-value = 3.8e-65 218496001209 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 218496001210 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 218496001211 alphaNTD - beta interaction site [polypeptide binding]; other site 218496001212 alphaNTD homodimer interface [polypeptide binding]; other site 218496001213 alphaNTD - beta' interaction site [polypeptide binding]; other site 218496001214 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 218496001215 Bacterial RNA polymerase, alpha chain, N terminal domain Score = 367.9 E-value = 7.6e-108 218496001216 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001217 Bacterial RNA polymerase, alpha chain C terminal domain Score = 115.3 E-value = 8.3e-32 218496001218 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 218496001219 Ribosomal protein L17 Score = 130.0 E-value = 3e-36 218496001220 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 218496001221 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 218496001222 dimerization interface 3.5A [polypeptide binding]; other site 218496001223 active site 218496001224 tRNA pseudouridine synthase Score = 83.2 E-value = 3.9e-22 218496001225 tRNA pseudouridine synthase Score = 42.0 E-value = 9.3e-10 218496001226 Domain of unknown function DUF59; Region: DUF59; cl00941 218496001227 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 218496001228 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 218496001229 Walker A motif; other site 218496001230 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family Score = 24.8 E-value = 3.1e-07 218496001231 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001232 Domain of unknown function DUF59 Score = 54.4 E-value = 1.8e-13 218496001233 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 218496001234 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 33-55 and 70-92 218496001235 MgtE intracellular N domain; Region: MgtE_N; cl15244 218496001236 FOG: CBS domain [General function prediction only]; Region: COG0517 218496001237 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 218496001238 CBS domain Score = 37.5 E-value = 2.2e-08 218496001239 CBS domain Score = 22.5 E-value = 0.00068 218496001240 MgtE intracellular domain Score = 58.7 E-value = 8.8e-15 218496001241 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 218496001242 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 218496001243 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 218496001244 active site 218496001245 metallopeptidase family M24 Score = 185.4 E-value = 6.3e-53 218496001246 PS00491 Aminopeptidase P and proline dipeptidase signature. 218496001247 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 218496001248 UvrD/REP helicase; Region: UvrD-helicase; cl14126 218496001249 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 218496001250 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001251 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 218496001252 UvrD/REP helicase; Region: UvrD-helicase; cl14126 218496001253 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 218496001254 UvrD/REP helicase Score = 189.1 E-value = 4.8e-54 218496001255 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001256 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.931) with cleavage site probability 0.359 between residues 28 and 29; signal peptide 218496001257 Phosphotransferase enzyme family; Region: APH; pfam01636 218496001258 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 218496001259 active site 218496001260 ATP binding site [chemical binding]; other site 218496001261 substrate binding site [chemical binding]; other site 218496001262 UvrD/REP helicase; Region: UvrD-helicase; cl14126 218496001263 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 218496001264 UvrD/REP helicase Score = 125.7 E-value = 5.9e-35 218496001265 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001266 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 218496001267 cell division protein FtsZ; Validated; Region: PRK09330 218496001268 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 218496001269 nucleotide binding site [chemical binding]; other site 218496001270 SulA interaction site; other site 218496001271 Tubulin/FtsZ family, GTPase domain Score = 293.0 E-value = 2.6e-85 218496001272 PS01134 FtsZ protein signature 1. 218496001273 PS01135 FtsZ protein signature 2. 218496001274 Tubulin/FtsZ family, C-terminal domain Score = 110.2 E-value = 2.8e-30 218496001275 Protein of unknown function (DUF552); Region: DUF552; cl00775 218496001276 Protein of unknown function (DUF552) Score = 105.1 E-value = 9.9e-29 218496001277 cell division protein GpsB; Provisional; Region: PRK14127 218496001278 DivIVA domain; Region: DivI1A_domain; TIGR03544 218496001279 lipoprotein signal peptidase; Provisional; Region: PRK14787 218496001280 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 218496001281 Signal peptidase (SPase) II Score = 51.6 E-value = 1.2e-12 218496001282 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 9-31, 56-78, 85-104 and 124-146 218496001283 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 218496001284 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 218496001285 active site 218496001286 RNA pseudouridylate synthase Score = 184.6 E-value = 1.1e-52 218496001287 PS01129 Rlu family of pseudouridine synthase signature. 218496001288 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 218496001289 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 218496001290 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 218496001291 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 218496001292 generic binding surface II; other site 218496001293 generic binding surface I; other site 218496001294 PHP domain N-terminal region Score = 123.8 E-value = 2.2e-34 218496001295 PHP domain C-terminal region Score = 124.3 E-value = 1.6e-34 218496001296 OB-fold nucleic acid binding domain Score = 50.6 E-value = 2.5e-12 218496001297 Integral membrane protein TerC family; Region: TerC; cl10468 218496001298 8 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 7-28, 43-65, 72-94, 98-115, 156-175, 180-202, 222-241 and 256-278 218496001299 Integral membrane protein TerC family Score = 166.4 E-value = 3.5e-47 218496001300 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 218496001301 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 218496001302 hinge; other site 218496001303 active site 218496001304 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) Score = 229.6 E-value = 3.2e-66 218496001305 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001306 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 218496001307 putative acyl-acceptor binding pocket; other site 218496001308 Acyltransferase Score = 77.5 E-value = 1.9e-20 218496001309 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 218496001310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218496001311 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 218496001312 NAD-dependent glycerol-3-phosphate dehydrogenase Score = 324.5 E-value = 8.9e-95 218496001313 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 218496001314 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 218496001315 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 218496001316 D-ala D-ala ligase Score = 313.1 E-value = 2.4e-91 218496001317 PS00843 D-alanine--D-alanine ligase signature 1. 218496001318 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.910 between residues 44 and 45; signal peptide 218496001319 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 218496001320 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218496001321 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 218496001322 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 218496001323 E3 interaction surface; other site 218496001324 lipoyl attachment site [posttranslational modification]; other site 218496001325 e3 binding domain; Region: E3_binding; pfam02817 218496001326 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 218496001327 2-oxo acid dehydrogenases acyltransferase (catalytic domain) Score = 345.2 E-value = 4.9e-101 218496001328 e3 binding domain Score = 55.3 E-value = 9.7e-14 218496001329 Biotin-requiring enzyme Score = 86.1 E-value = 5.2e-23 218496001330 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 218496001331 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 218496001332 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 218496001333 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 218496001334 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218496001335 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Score = 126.5 E-value = 3.6e-35 218496001336 Pyridine nucleotide-disulphide oxidoreductase Score = 273.2 E-value = 2.3e-79 218496001337 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 218496001338 multifunctional aminopeptidase A; Provisional; Region: PRK00913 218496001339 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 218496001340 interface (dimer of trimers) [polypeptide binding]; other site 218496001341 Substrate-binding/catalytic site; other site 218496001342 Zn-binding sites [ion binding]; other site 218496001343 Cytosol aminopeptidase family, catalytic domain Score = 408.1 E-value = 5.7e-120 218496001344 PS00631 Cytosol aminopeptidase signature. 218496001345 Cytosol aminopeptidase family, N-terminal domain Score = 25.8 E-value = 6.8e-05 218496001346 glycyl-tRNA synthetase; Provisional; Region: PRK14908 218496001347 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 218496001348 dimer interface [polypeptide binding]; other site 218496001349 motif 1; other site 218496001350 active site 218496001351 motif 2; other site 218496001352 motif 3; other site 218496001353 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 218496001354 Glycyl-tRNA synthetase beta subunit Score = 342.0 E-value = 4.7e-100 218496001355 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001356 Glycyl-tRNA synthetase alpha subunit Score = 579.1 E-value = 1.9e-171 218496001357 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 218496001358 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 218496001359 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218496001360 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 218496001361 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 218496001362 Sigma-70 factor, region 1.2 Score = 68.6 E-value = 9.5e-18 218496001363 Sigma-70 region 2 Score = 103.3 E-value = 3.3e-28 218496001364 PS00715 Sigma-70 factors family signature 1. 218496001365 Sigma-70 region 3 Score = 143.0 E-value = 3.8e-40 218496001366 Sigma-70, region 4 Score = 70.7 E-value = 2.2e-18 218496001367 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 218496001368 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218496001369 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 218496001370 Mur ligase family, catalytic domain Score = 28.9 E-value = 1.3e-08 218496001371 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 218496001372 catalytic triad [active] 218496001373 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 218496001374 alanine racemase; Reviewed; Region: alr; PRK00053 218496001375 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218496001376 catalytic residue [active] 218496001377 Alanine racemase Score = -93.7 E-value = 8e-08 218496001378 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 218496001379 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 218496001380 Alanine racemase Score = -136.6 E-value = 8.7e-06 218496001381 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 218496001382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218496001383 ATP binding site [chemical binding]; other site 218496001384 Mg2+ binding site [ion binding]; other site 218496001385 G-X-G motif; other site 218496001386 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 218496001387 anchoring element; other site 218496001388 dimer interface [polypeptide binding]; other site 218496001389 ATP binding site [chemical binding]; other site 218496001390 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 218496001391 active site 218496001392 metal binding site [ion binding]; metal-binding site 218496001393 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 218496001394 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Score = 81.0 E-value = 1.7e-21 218496001395 DNA gyrase B Score = 116.2 E-value = 4.4e-32 218496001396 PS00177 DNA topoisomerase II signature. 218496001397 Toprim domain Score = 29.8 E-value = 4.5e-06 218496001398 DNA gyrase B subunit, carboxyl terminus Score = 111.5 E-value = 1.1e-30 218496001399 Pseudogene. Similar to Escherichia coli protease II PtrB or Tlp or b1845 SWALL:PTRB_ECOLI (SWALL:P24555) (686 aa) fasta scores: E(): 9.4e-45, 30.41% id in 720 aa, and to Moraxella lacunata protease II PtrB SWALL:PTRB_MORLA (SWALL:Q59536) (690 aa) fasta scores: E(): 1.2e-52, 33.6% id in 729 aa;protease ii 218496001400 Prolyl oligopeptidase family Score = 107.4 E-value = 2e-29 218496001401 Prolyl oligopeptidase, N-terminal beta-propeller domain Score = 59.2 E-value = 3.6e-18 218496001402 Prolyl oligopeptidase, N-terminal beta-propeller domain Score = 26.6 E-value = 2.1e-08 218496001403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218496001404 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 218496001405 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 218496001406 NAD binding domain of 6-phosphogluconate dehydrogenase Score = 261.6 E-value = 7.5e-76 218496001407 6-phosphogluconate dehydrogenase, C-terminal domain Score = 442.0 E-value = 3.8e-130 218496001408 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 218496001409 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 218496001410 CAP-like domain; other site 218496001411 Active site [active] 218496001412 primary dimer interface [polypeptide binding]; other site 218496001413 DNA gyrase C-terminal domain, beta-propeller Score = 25.5 E-value = 9.1e-05 218496001414 DNA gyrase/topoisomerase IV, subunit A Score = 715.1 E-value = 2.2e-212 218496001415 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 218496001416 Predicted helix-turn-helix motif with score 1162.000, SD 3.14 at aa 79-100, sequence LPAEKVAQKLSTSIERVKRFEP 218496001417 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.976) with cleavage site probability 0.938 between residues 36 and 37; signal peptide 218496001418 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 218496001419 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 12-34 and 39-61 218496001420 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 218496001421 trimer interface [polypeptide binding]; other site 218496001422 active site 218496001423 dUTPase Score = 139.9 E-value = 3.2e-39 218496001424 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 218496001425 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 218496001426 5 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 52-74, 81-103, 108-142, 155-177 and 192-210 218496001427 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 218496001428 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 218496001429 TPP-binding site; other site 218496001430 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 218496001431 PYR/PP interface [polypeptide binding]; other site 218496001432 dimer interface [polypeptide binding]; other site 218496001433 TPP binding site [chemical binding]; other site 218496001434 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218496001435 PS00801 Transketolase signature 1. 218496001436 Transketolase, pyridine binding domain Score = 187.2 E-value = 1.9e-53 218496001437 Transketolase, C-terminal domain Score = 37.5 E-value = 2.2e-08 218496001438 trigger factor; Provisional; Region: tig; PRK01490 218496001439 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.488 between residues 62 and 63; signal peptide 218496001440 10 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 20-42, 68-90, 102-124, 137-156, 163-182, 197-219, 226-248, 263-285, 306-328 and 343-365 218496001441 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 218496001442 oligomer interface [polypeptide binding]; other site 218496001443 active site residues [active] 218496001444 Clp protease Score = 282.2 E-value = 4.5e-82 218496001445 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 218496001446 oligomer interface [polypeptide binding]; other site 218496001447 active site residues [active] 218496001448 Clp protease Score = 283.0 E-value = 2.6e-82 218496001449 PS00381 Endopeptidase Clp serine active site. 218496001450 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 218496001451 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 218496001452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 218496001453 Walker A motif; other site 218496001454 ATP binding site [chemical binding]; other site 218496001455 Walker B motif; other site 218496001456 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 218496001457 ATPase family associated with various cellular activities (AAA) Score = 79.5 E-value = 4.9e-21 218496001458 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001459 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 218496001460 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218496001461 active site 218496001462 HIGH motif; other site 218496001463 nucleotide binding site [chemical binding]; other site 218496001464 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 218496001465 active site 218496001466 KMSKS motif; other site 218496001467 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 218496001468 tRNA binding surface [nucleotide binding]; other site 218496001469 anticodon binding site; other site 218496001470 tRNA synthetases class I (I, L, M and V) Score = 155.0 E-value = 9.4e-44 218496001471 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218496001472 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 218496001473 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 218496001474 HIGH motif; other site 218496001475 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 218496001476 active site 218496001477 KMSKS motif; other site 218496001478 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 218496001479 tRNA binding surface [nucleotide binding]; other site 218496001480 anticodon binding site; other site 218496001481 tRNA synthetases class I (I, L, M and V) Score = 626.0 E-value = 1.5e-185 218496001482 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 218496001483 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218496001484 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218496001485 Mur ligase family, catalytic domain Score = 34.0 E-value = 1.1e-07 218496001486 PS01011 Folylpolyglutamate synthase signature 1. 218496001487 PS01012 Folylpolyglutamate synthase signature 2. 218496001488 Mur ligase family, glutamate ligase domain Score = 27.3 E-value = 2.6e-05 218496001489 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.899) with cleavage site probability 0.318 between residues 60 and 61; signal peptide 218496001490 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 12-29, 39-61 and 74-96 218496001491 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 218496001492 active site 218496001493 multimer interface [polypeptide binding]; other site 218496001494 Nucleoside diphosphate kinase Score = 164.4 E-value = 1.3e-46 218496001495 PS00469 Nucleoside diphosphate kinases active site. 218496001496 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 218496001497 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 218496001498 homodimer interface [polypeptide binding]; other site 218496001499 oligonucleotide binding site [chemical binding]; other site 218496001500 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 218496001501 Ribosomal prokaryotic L21 protein Score = 73.3 E-value = 3.7e-19 218496001502 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 218496001503 Ribosomal L27 protein Score = 165.7 E-value = 5.7e-47 218496001504 PS00831 Ribosomal protein L27 signature. 218496001505 GTPase CgtA; Reviewed; Region: obgE; PRK12297 218496001506 GTP1/OBG; Region: GTP1_OBG; pfam01018 218496001507 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 218496001508 G1 box; other site 218496001509 GTP/Mg2+ binding site [chemical binding]; other site 218496001510 Switch I region; other site 218496001511 G2 box; other site 218496001512 G3 box; other site 218496001513 Switch II region; other site 218496001514 G4 box; other site 218496001515 G5 box; other site 218496001516 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 218496001517 GTP1/OBG family Score = 366.1 E-value = 2.6e-107 218496001518 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001519 PS00905 GTP1/OBG family signature. 218496001520 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 23-45 218496001521 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 218496001522 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 218496001523 active site 218496001524 (T/H)XGH motif; other site 218496001525 Cytidylyltransferase Score = 135.4 E-value = 7e-38 218496001526 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 278-300 218496001527 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.504 between residues 51 and 52; signal peptide 218496001528 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 218496001529 putative catalytic site [active] 218496001530 putative phosphate binding site [ion binding]; other site 218496001531 putative metal binding site [ion binding]; other site 218496001532 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 21-43, 58-80 and 87-109 218496001533 Endonuclease/Exonuclease/phosphatase family Score = 36.3 E-value = 5e-08 218496001534 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 218496001535 DNA binding site [nucleotide binding] 218496001536 active site 218496001537 6-O-methylguanine DNA methyltransferase, DNA binding domain Score = 82.2 E-value = 7.7e-22 218496001538 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 218496001539 Predicted helix-turn-helix motif with score 1060.000, SD 2.80 at aa 120-141, sequence VSYGEIASKVNSSPRAVGAYCA 218496001540 lipoyl synthase; Provisional; Region: PRK05481 218496001541 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 218496001542 Radical SAM superfamily Score = 63.6 E-value = 3.1e-16 218496001543 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 218496001544 Biotin/lipoate A/B protein ligase family Score = 113.2 E-value = 3.6e-31 218496001545 PS01313 Lipoate-protein ligase B signature. 218496001546 signal recognition particle protein; Provisional; Region: PRK10867 218496001547 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 218496001548 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 218496001549 P loop; other site 218496001550 GTP binding site [chemical binding]; other site 218496001551 Signal peptide binding domain Score = 77.6 E-value = 1.8e-20; signal peptide 218496001552 Signal peptide binding domain; Region: SRP_SPB; pfam02978 218496001553 SRP54-type protein, helical bundle domain Score = 65.4 E-value = 8.8e-17 218496001554 SRP54-type protein, GTPase domain Score = 269.3 E-value = 3.6e-78 218496001555 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001556 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 218496001557 Ribosomal protein S16 Score = 57.4 E-value = 2.2e-14 218496001558 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 218496001559 KH domain Score = 21.4 E-value = 1.1e-05 218496001560 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 218496001561 RimM N-terminal domain; Region: RimM; pfam01782 218496001562 RimM Score = 51.0 E-value = 1.9e-12 218496001563 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 218496001564 PS00430 TonB-dependent receptor proteins signature 1. 218496001565 tRNA (Guanine-1)-methyltransferase Score = 350.8 E-value = 1.1e-102 218496001566 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 218496001567 Ribosomal protein L19 Score = 189.8 E-value = 3.1e-54 218496001568 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 218496001569 Catalytic site [active] 218496001570 Signal peptidase I Score = 55.6 E-value = 7.9e-14 218496001571 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 21-43 218496001572 PS00761 Signal peptidases I signature 3. 218496001573 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 218496001574 Uncharacterised protein family UPF0102 Score = 72.7 E-value = 5.4e-19 218496001575 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 218496001576 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 218496001577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 218496001578 Walker A motif; other site 218496001579 ATP binding site [chemical binding]; other site 218496001580 Walker B motif; other site 218496001581 Magnesium chelatase, subunit ChlI Score = 159.0 E-value = 5.7e-45 218496001582 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001583 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 218496001584 SMF family Score = 217.7 E-value = 1.2e-62 218496001585 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218496001586 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 218496001587 DNA binding site [nucleotide binding] 218496001588 Int/Topo IB signature motif; other site 218496001589 active site 218496001590 Phage integrase, N-terminal SAM-like domain Score = 58.6 E-value = 9.7e-15 218496001591 Phage integrase family Score = 137.8 E-value = 1.4e-38 218496001592 Peptidase family M23; Region: Peptidase_M23; pfam01551 218496001593 Peptidase family M23/M37 Score = 36.2 E-value = 5.3e-08 218496001594 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 218496001595 rRNA interaction site [nucleotide binding]; other site 218496001596 S8 interaction site; other site 218496001597 putative laminin-1 binding site; other site 218496001598 Ribosomal protein S2 Score = 273.4 E-value = 2.1e-79 218496001599 elongation factor Ts; Provisional; Region: tsf; PRK09377 218496001600 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 218496001601 Elongation factor TS; Region: EF_TS; pfam00889 218496001602 Elongation factor TS; Region: EF_TS; pfam00889 218496001603 UBA/TS-N domain Score = 32.0 E-value = 9.5e-07 218496001604 Elongation factor TS Score = 216.4 E-value = 2.9e-62 218496001605 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 218496001606 putative nucleotide binding site [chemical binding]; other site 218496001607 uridine monophosphate binding site [chemical binding]; other site 218496001608 homohexameric interface [polypeptide binding]; other site 218496001609 Amino acid kinase family Score = 203.3 E-value = 2.7e-58 218496001610 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 218496001611 hinge region; other site 218496001612 Ribosome recycling factor Score = 158.3 E-value = 9.2e-45 218496001613 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 218496001614 8 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 13-30, 34-56, 63-85, 89-108, 115-137, 141-163, 176-198 and 203-220 218496001615 Phosphatidate cytidylyltransferase Score = 170.2 E-value = 2.4e-48 218496001616 PS01315 Phosphatidate cytidylyltransferase signature. 218496001617 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 218496001618 putative phosphate binding site [ion binding]; other site 218496001619 putative catalytic site [active] 218496001620 active site 218496001621 metal binding site A [ion binding]; metal-binding site 218496001622 DNA binding site [nucleotide binding] 218496001623 putative AP binding site [nucleotide binding]; other site 218496001624 putative metal binding site B [ion binding]; other site 218496001625 Endonuclease/Exonuclease/phosphatase family Score = 131.7 E-value = 9.2e-37 218496001626 PS00728 AP endonucleases family 1 signature 3. 218496001627 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 218496001628 DivIVA domain; Region: DivI1A_domain; TIGR03544 218496001629 DivIVA domain; Region: DivI1A_domain; TIGR03544 218496001630 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.797 between residues 54 and 55; signal peptide 218496001631 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 218496001632 N-acetyl-D-glucosamine binding site [chemical binding]; other site 218496001633 catalytic residue [active] 218496001634 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 30-52 218496001635 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 218496001636 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 218496001637 ring oligomerisation interface [polypeptide binding]; other site 218496001638 ATP/Mg binding site [chemical binding]; other site 218496001639 stacking interactions; other site 218496001640 hinge regions; other site 218496001641 TCP-1/cpn60 chaperonin family Score = 660.1 E-value = 8.4e-196 218496001642 PS00296 Chaperonins cpn60 signature. 218496001643 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.674) with cleavage site probability 0.179 between residues 19 and 20; signal peptide 218496001644 7 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 24-41, 45-64, 71-90, 110-132, 145-167, 172-194 and 215-237 218496001645 homoserine dehydrogenase; Provisional; Region: PRK06349 218496001646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218496001647 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 218496001648 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 218496001649 Homoserine dehydrogenase, NAD binding domain Score = 91.8 E-value = 9.7e-25 218496001650 Homoserine dehydrogenase Score = 250.4 E-value = 1.7e-72 218496001651 PS01042 Homoserine dehydrogenase signature. 218496001652 threonine synthase; Reviewed; Region: PRK06721 218496001653 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 218496001654 homodimer interface [polypeptide binding]; other site 218496001655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218496001656 catalytic residue [active] 218496001657 Pyridoxal-phosphate dependent enzyme Score = 265.9 E-value = 3.8e-77 218496001658 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 218496001659 homoserine kinase; Provisional; Region: PRK01212 218496001660 GHMP kinases putative ATP-binding protein Score = 133.0 E-value = 3.8e-37 218496001661 transcription termination factor Rho; Provisional; Region: rho; PRK09376 218496001662 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 218496001663 RNA binding site [nucleotide binding]; other site 218496001664 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 218496001665 Walker A motif; other site 218496001666 ATP binding site [chemical binding]; other site 218496001667 Walker B motif; other site 218496001668 ATP synthase alpha/beta family, nucleotide-binding domain Score = 62.7 E-value = 5.7e-16 218496001669 PS00152 ATP synthase alpha and beta subunits signature. 218496001670 peptide chain release factor 1; Validated; Region: prfA; PRK00591 218496001671 RF-1 domain; Region: RF-1; cl02875 218496001672 RF-1 domain; Region: RF-1; cl02875 218496001673 PCRF domain Score = 123.5 E-value = 2.8e-34 218496001674 Peptidyl-tRNA hydrolase domain Score = 212.9 E-value = 3.4e-61 218496001675 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 218496001676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 218496001677 S-adenosylmethionine binding site [chemical binding]; other site 218496001678 PS00092 N-6 Adenine-specific DNA methylases signature. 218496001679 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 218496001680 yrdC domain Score = 122.0 E-value = 8e-34 218496001681 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 218496001682 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 218496001683 Mg++ binding site [ion binding]; other site 218496001684 putative catalytic motif [active] 218496001685 substrate binding site [chemical binding]; other site 218496001686 11 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 4-26, 47-69, 79-98, 105-127, 137-156, 163-182, 192-214, 226-248, 258-280, 310-332 and 336-358 218496001687 Glycosyl transferase Score = 107.7 E-value = 1.6e-29 218496001688 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 20-42, 49-71, 81-103 and 115-137 218496001689 ATP synthase A chain; Region: ATP-synt_A; cl00413 218496001690 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 46-65, 103-125, 130-152, 173-195, 217-239 and 246-268 218496001691 ATP synthase A chain Score = 111.9 E-value = 8.9e-31 218496001692 ATP synthase subunit C; Region: ATP-synt_C; cl00466 218496001693 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 10-32 and 52-74 218496001694 ATP synthase subunit C Score = 67.7 E-value = 1.8e-17 218496001695 PS00605 ATP synthase c subunit signature. 218496001696 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 218496001697 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 218496001698 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 15-37 218496001699 ATP synthase B/B' CF(0) Score = 89.7 E-value = 4.3e-24 218496001700 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 218496001701 ATP synthase delta (OSCP) subunit Score = -30.5 E-value = 2.2e-05 218496001702 PS00389 ATP synthase delta (OSCP) subunit signature. 218496001703 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 218496001704 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 218496001705 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 218496001706 beta subunit interaction interface [polypeptide binding]; other site 218496001707 Walker A motif; other site 218496001708 ATP binding site [chemical binding]; other site 218496001709 Walker B motif; other site 218496001710 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 218496001711 ATP synthase alpha/beta family, beta-barrel domain Score = 66.7 E-value = 3.4e-17 218496001712 ATP synthase alpha/beta family, nucleotide-binding domain Score = 503.6 E-value = 1.1e-148 218496001713 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001714 PS00152 ATP synthase alpha and beta subunits signature. 218496001715 ATP synthase alpha/beta chain, C terminal domain Score = 86.0 E-value = 5.2e-23 218496001716 ATP synthase; Region: ATP-synt; cl00365 218496001717 ATP synthase Score = 294.3 E-value = 1.1e-85 218496001718 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 218496001719 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 218496001720 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 218496001721 alpha subunit interaction interface [polypeptide binding]; other site 218496001722 Walker A motif; other site 218496001723 ATP binding site [chemical binding]; other site 218496001724 Walker B motif; other site 218496001725 inhibitor binding site; inhibition site 218496001726 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 218496001727 ATP synthase alpha/beta family, beta-barrel domain Score = 94.3 E-value = 1.7e-25 218496001728 ATP synthase alpha/beta family, nucleotide-binding domain Score = 454.9 E-value = 4.9e-134 218496001729 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001730 PS00152 ATP synthase alpha and beta subunits signature. 218496001731 ATP synthase alpha/beta chain, C terminal domain Score = 152.0 E-value = 7.5e-43 218496001732 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 218496001733 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Score = 24.1 E-value = 6.8e-06 218496001734 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 15-37 218496001735 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 218496001736 16S/18S rRNA binding site [nucleotide binding]; other site 218496001737 S13e-L30e interaction site [polypeptide binding]; other site 218496001738 25S rRNA binding site [nucleotide binding]; other site 218496001739 Ribosomal protein S15 Score = 122.3 E-value = 6.2e-34 218496001740 PS00362 Ribosomal protein S15 signature. 218496001741 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 218496001742 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 218496001743 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 218496001744 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 218496001745 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 218496001746 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 218496001747 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 218496001748 putative nucleic acid binding region [nucleotide binding]; other site 218496001749 G-X-X-G motif; other site 218496001750 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 218496001751 RNA binding site [nucleotide binding]; other site 218496001752 domain interface; other site 218496001753 3' exoribonuclease family, domain 1 Score = 111.4 E-value = 1.2e-30 218496001754 3' exoribonuclease family, domain 2 Score = 20.7 E-value = 1.3e-05 218496001755 Polyribonucleotide nucleotidyltransferase, RNA binding domain Score = 7.5 E-value = 0.00036 218496001756 3' exoribonuclease family, domain 1 Score = 162.4 E-value = 5.4e-46 218496001757 3' exoribonuclease family, domain 2 Score = 82.4 E-value = 6.5e-22 218496001758 KH domain Score = 41.9 E-value = 1e-09 218496001759 S1 RNA binding domain Score = 39.9 E-value = 4.1e-09 218496001760 Cation efflux family; Region: Cation_efflux; cl00316 218496001761 Cation efflux family Score = 222.9 E-value = 3.3e-64 218496001762 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 26-48, 58-77, 90-112, 127-149, 156-178 and 183-205 218496001763 Domain of unknown function DUF20; Region: UPF0118; cl00465 218496001764 Domain of unknown function DUF20 Score = 138.3 E-value = 9.5e-39 218496001765 8 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 20-42, 49-71, 81-103, 161-183, 224-246, 253-275, 285-307 and 320-351 218496001766 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 218496001767 flagellar assembly protein H; Validated; Region: fliH; PRK06669 218496001768 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.811) with cleavage site probability 0.388 between residues 35 and 36; signal peptide 218496001769 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 21-43, 184-206 and 232-254 218496001770 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 218496001771 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218496001772 catalytic residue [active] 218496001773 Aminotransferase class-V Score = 100.2 E-value = 2.8e-27 218496001774 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 218496001775 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 218496001776 tRNA methyl transferase Score = 490.6 E-value = 8.4e-145 218496001777 Ligase N family; Region: LIGANc; smart00532 218496001778 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 218496001779 nucleotide binding pocket [chemical binding]; other site 218496001780 K-X-D-G motif; other site 218496001781 catalytic site [active] 218496001782 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 218496001783 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 218496001784 NAD-dependent DNA ligase adenylation domain Score = 285.4 E-value = 5e-83 218496001785 NAD-dependent DNA ligase OB-fold domain Score = 143.6 E-value = 2.4e-40 218496001786 NAD-dependent DNA ligase C4 zinc finger domain Score = 28.3 E-value = 1.3e-05 218496001787 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 218496001788 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 218496001789 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 218496001790 Amidase Score = 549.4 E-value = 1.7e-162 218496001791 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 218496001792 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 218496001793 GatB domain; Region: GatB_Yqey; cl11497 218496001794 PET112 family, N terminal region Score = 431.1 E-value = 7.1e-127 218496001795 PS01234 PET112 family signature. 218496001796 PET112 family, C terminal region Score = 52.0 E-value = 9.3e-13 218496001797 GatB/Yqey domain Score = 83.8 E-value = 2.4e-22 218496001798 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.381 between residues 30 and 31; signal peptide 218496001799 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 218496001800 putative catalytic site [active] 218496001801 putative phosphate binding site [ion binding]; other site 218496001802 putative metal binding site [ion binding]; other site 218496001803 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 5-20 and 35-57 218496001804 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 218496001805 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 3-25, 29-48, 53-75, 79-96, 103-125 and 130-152 218496001806 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 218496001807 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 218496001808 Walker A/P-loop; other site 218496001809 ATP binding site [chemical binding]; other site 218496001810 Q-loop/lid; other site 218496001811 ABC transporter signature motif; other site 218496001812 Walker B; other site 218496001813 D-loop; other site 218496001814 H-loop/switch region; other site 218496001815 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 218496001816 Walker A/P-loop; other site 218496001817 ATP binding site [chemical binding]; other site 218496001818 Q-loop/lid; other site 218496001819 ABC transporter signature motif; other site 218496001820 Walker B; other site 218496001821 D-loop; other site 218496001822 H-loop/switch region; other site 218496001823 ABC transporter Score = 111.0 E-value = 1.6e-30 218496001824 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001825 PS00211 ABC transporters family signature. 218496001826 ABC transporter Score = 113.0 E-value = 4e-31 218496001827 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001828 Cobalt transport protein; Region: CbiQ; cl00463 218496001829 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 15-34, 55-77, 102-124 and 218-240 218496001830 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 5-27 and 48-70 218496001831 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 218496001832 putative active site [active] 218496001833 putative substrate binding site [chemical binding]; other site 218496001834 catalytic site [active] 218496001835 dimer interface [polypeptide binding]; other site 218496001836 Exonuclease Score = 87.7 E-value = 1.6e-23 218496001837 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 218496001838 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 218496001839 homodimer interface [polypeptide binding]; other site 218496001840 NAD binding pocket [chemical binding]; other site 218496001841 ATP binding pocket [chemical binding]; other site 218496001842 Mg binding site [ion binding]; other site 218496001843 active-site loop [active] 218496001844 NAD synthase Score = 170.5 E-value = 2e-48 218496001845 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 15-37 218496001846 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 218496001847 dimer interface [polypeptide binding]; other site 218496001848 ssDNA binding site [nucleotide binding]; other site 218496001849 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218496001850 Single-strand binding protein family Score = 20.5 E-value = 2.7e-06 218496001851 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.973) with cleavage site probability 0.654 between residues 50 and 51; signal peptide 218496001852 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 21-43 218496001853 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 218496001854 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 218496001855 Walker A/P-loop; other site 218496001856 ATP binding site [chemical binding]; other site 218496001857 Q-loop/lid; other site 218496001858 ABC transporter signature motif; other site 218496001859 Walker B; other site 218496001860 D-loop; other site 218496001861 H-loop/switch region; other site 218496001862 ABC transporter; Region: ABC_tran_2; pfam12848 218496001863 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 218496001864 ABC transporter Score = 175.2 E-value = 7.6e-50 218496001865 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001866 PS00211 ABC transporters family signature. 218496001867 ABC transporter Score = 121.8 E-value = 9.2e-34 218496001868 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001869 PS00211 ABC transporters family signature. 218496001870 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 218496001871 active site 218496001872 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 218496001873 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 218496001874 Zn binding site [ion binding]; other site 218496001875 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 218496001876 Peptidase family M1 Score = 279.5 E-value = 3e-81 218496001877 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218496001878 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 218496001879 Ribose/Galactose Isomerase Score = 127.6 E-value = 1.6e-35 218496001880 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 218496001881 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 218496001882 putative DNA binding site [nucleotide binding]; other site 218496001883 catalytic residue [active] 218496001884 putative H2TH interface [polypeptide binding]; other site 218496001885 putative catalytic residues [active] 218496001886 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 218496001887 Formamidopyrimidine-DNA glycosylase Score = 88.0 E-value = 1.3e-23 218496001888 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 218496001889 dimerization interface [polypeptide binding]; other site 218496001890 DPS ferroxidase diiron center [ion binding]; other site 218496001891 ion pore; other site 218496001892 Ferritin-like domain Score = 20.1 E-value = 0.00014 218496001893 PS00818 Dps protein family signature 1. 218496001894 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 218496001895 putative active site [active] 218496001896 catalytic site [active] 218496001897 putative substrate binding site [chemical binding]; other site 218496001898 HRDC domain; Region: HRDC; cl02578 218496001899 HRDC domain Score = 26.1 E-value = 1.9e-05 218496001900 3'-5' exonuclease Score = 69.7 E-value = 4.4e-18 218496001901 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 218496001902 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 218496001903 RibD C-terminal domain Score = -30.5 E-value = 4.5e-06 218496001904 Fe-S metabolism associated domain; Region: SufE; cl00951 218496001905 Domain of unknown function DUF Score = 60.8 E-value = 2.1e-15 218496001906 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 218496001907 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 218496001908 active site residue [active] 218496001909 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 218496001910 active site residue [active] 218496001911 Rhodanese-like domain Score = 82.2 E-value = 7.5e-22 218496001912 Rhodanese-like domain Score = 72.4 E-value = 6.6e-19 218496001913 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.995 between residues 32 and 33; signal peptide 218496001914 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 218496001915 catalytic residue [active] 218496001916 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 13-32 218496001917 Predicted membrane protein [Function unknown]; Region: COG4129 218496001918 5 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 34-56, 71-93, 100-117, 122-144 and 151-170 218496001919 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 218496001920 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 218496001921 Uncharacterized conserved protein (DUF2183); Region: DUF2183; cl02012 218496001922 5 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 17-39, 59-81, 113-135, 140-162 and 175-194 218496001923 DedA family Score = 53.6 E-value = 3e-13 218496001924 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 218496001925 chorismate binding enzyme; Region: Chorismate_bind; cl10555 218496001926 chorismate binding enzyme Score = 354.4 E-value = 8.6e-104 218496001927 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 218496001928 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 218496001929 HIGH motif; other site 218496001930 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218496001931 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218496001932 active site 218496001933 KMSKS motif; other site 218496001934 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 218496001935 tRNA binding surface [nucleotide binding]; other site 218496001936 tRNA synthetases class I (I, L, M and V) Score = 369.9 E-value = 1.9e-108 218496001937 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218496001938 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.948) with cleavage site probability 0.625 between residues 37 and 38; signal peptide 218496001939 SLBB domain; Region: SLBB; pfam10531 218496001940 comEA protein; Region: comE; TIGR01259 218496001941 Protein of unknown function, DUF655; Region: DUF655; cl00648 218496001942 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 13-32 218496001943 Competence protein; Region: Competence; cl00471 218496001944 10 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 7-29, 44-63, 215-237, 247-269, 281-303, 307-326, 339-361, 376-398, 405-424 and 434-456 218496001945 Competence protein Score = 118.4 E-value = 9.7e-33 218496001946 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 218496001947 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 7-29 218496001948 hypothetical protein; Reviewed; Region: PRK07914 218496001949 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 218496001950 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 218496001951 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 218496001952 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 218496001953 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 218496001954 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218496001955 RNA binding surface [nucleotide binding]; other site 218496001956 Ribosomal protein S4/S9 N-terminal domain Score = 51.1 E-value = 1.7e-12 218496001957 S4 domain Score = 69.1 E-value = 6.6e-18 218496001958 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 218496001959 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 218496001960 motif 1; other site 218496001961 active site 218496001962 motif 2; other site 218496001963 motif 3; other site 218496001964 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 218496001965 tRNA synthetases class II (A) Score = 912.9 E-value = 6.3e-272 218496001966 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218496001967 DHHA1 domain Score = 18.1 E-value = 4.6e-05 218496001968 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 218496001969 Uncharacterised protein family (UPF0081) Score = 73.3 E-value = 3.7e-19 218496001970 Uncharacterized BCR, YceG family COG1559 Score = 231.6 E-value = 8.2e-67 218496001971 YceG-like family; Region: YceG; pfam02618 218496001972 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 218496001973 dimerization interface [polypeptide binding]; other site 218496001974 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 63-85 218496001975 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 218496001976 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 218496001977 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 218496001978 shikimate binding site; other site 218496001979 NAD(P) binding site [chemical binding]; other site 218496001980 Shikimate / quinate 5-dehydrogenase Score = 81.6 E-value = 1.1e-21 218496001981 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 218496001982 Tetramer interface [polypeptide binding]; other site 218496001983 Active site [active] 218496001984 FMN-binding site [chemical binding]; other site 218496001985 Chorismate synthase Score = 497.9 E-value = 5.6e-147 218496001986 PS00787 Chorismate synthase signature 1. 218496001987 PS00788 Chorismate synthase signature 2. 218496001988 shikimate kinase; Reviewed; Region: aroK; PRK00131 218496001989 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 218496001990 ADP binding site [chemical binding]; other site 218496001991 magnesium binding site [ion binding]; other site 218496001992 putative shikimate binding site; other site 218496001993 Shikimate kinase Score = 64.5 E-value = 1.7e-16 218496001994 PS00017 ATP/GTP-binding site motif A (P-loop). 218496001995 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 218496001996 dimer interface [polypeptide binding]; other site 218496001997 active site 218496001998 metal binding site [ion binding]; metal-binding site 218496001999 3-dehydroquinate synthase Score = 341.6 E-value = 6.3e-100 218496002000 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 218496002001 trimer interface [polypeptide binding]; other site 218496002002 active site 218496002003 dimer interface [polypeptide binding]; other site 218496002004 Dehydroquinase class II Score = 197.0 E-value = 2e-56 218496002005 PS01029 Dehydroquinase class II signature. 218496002006 elongation factor P; Validated; Region: PRK00529 218496002007 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 218496002008 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 218496002009 RNA binding site [nucleotide binding]; other site 218496002010 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 218496002011 RNA binding site [nucleotide binding]; other site 218496002012 Elongation factor P (EF-P) Score = 334.1 E-value = 1.1e-97 218496002013 PS01275 Elongation factor P signature. 218496002014 dihydroorotase; Validated; Region: pyrC; PRK09357 218496002015 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 218496002016 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 218496002017 active site 218496002018 Dihydroorotase-like Score = 247.0 E-value = 1.8e-71 218496002019 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 218496002020 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 218496002021 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 218496002022 catalytic site [active] 218496002023 subunit interface [polypeptide binding]; other site 218496002024 Carbamoyl-phosphate synthase small chain, CPSase domain Score = 205.4 E-value = 6e-59 218496002025 Glutamine amidotransferase class-I Score = 152.0 E-value = 7.3e-43 218496002026 PS00442 Glutamine amidotransferases class-I active site. 218496002027 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 218496002028 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218496002029 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 218496002030 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 218496002031 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218496002032 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 218496002033 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 218496002034 IMP binding site; other site 218496002035 dimer interface [polypeptide binding]; other site 218496002036 interdomain contacts; other site 218496002037 partial ornithine binding site; other site 218496002038 Carbamoyl-phosphate synthase L chain, N-terminal domain Score = 175.9 E-value = 4.8e-50 218496002039 Carbamoyl-phosphate synthase L chain, ATP binding domain Score = 360.7 E-value = 1.1e-105 218496002040 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 218496002041 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 218496002042 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Score = 177.0 E-value = 2.1e-50 218496002043 Carbamoyl-phosphate synthase L chain, N-terminal domain Score = 72.6 E-value = 5.7e-19 218496002044 Carbamoyl-phosphate synthase L chain, ATP binding domain Score = 68.4 E-value = 1.1e-17 218496002045 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 218496002046 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 218496002047 MGS-like domain Score = 97.1 E-value = 2.4e-26 218496002048 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 218496002049 active site 218496002050 dimer interface [polypeptide binding]; other site 218496002051 Orotidine 5'-phosphate decarboxylase / HUMPS family Score = 52.7 E-value = 5.5e-13 218496002052 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 218496002053 catalytic site [active] 218496002054 G-X2-G-X-G-K; other site 218496002055 PS00856 Guanylate kinase signature. 218496002056 Guanylate kinase Score = 89.2 E-value = 6e-24 218496002057 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 218496002058 RNA polymerase Rpb6 Score = 46.6 E-value = 3.8e-11 218496002059 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 218496002060 Flavoprotein; Region: Flavoprotein; cl08021 218496002061 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 218496002062 Flavoprotein Score = 110.4 E-value = 2.5e-30 218496002063 DNA / pantothenate metabolism flavoprotein Score = 114.7 E-value = 1.2e-31 218496002064 S-adenosylmethionine synthetase; Validated; Region: PRK05250 218496002065 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 218496002066 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 218496002067 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 218496002068 S-adenosylmethionine synthetase, N-terminal domain Score = 125.2 E-value = 8.5e-35 218496002069 S-adenosylmethionine synthetase, central domain Score = 174.5 E-value = 1.2e-49 218496002070 S-adenosylmethionine synthetase, C-terminal domain Score = 227.1 E-value = 1.8e-65 218496002071 primosome assembly protein PriA; Provisional; Region: PRK14873 218496002072 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 218496002073 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 218496002074 putative active site [active] 218496002075 substrate binding site [chemical binding]; other site 218496002076 putative cosubstrate binding site; other site 218496002077 catalytic site [active] 218496002078 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 218496002079 substrate binding site [chemical binding]; other site 218496002080 Formyl transferase Score = 53.1 E-value = 4.3e-13 218496002081 Formyl transferase, C-terminal domain Score = 50.7 E-value = 2.3e-12 218496002082 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 218496002083 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 218496002084 substrate binding site [chemical binding]; other site 218496002085 hexamer interface [polypeptide binding]; other site 218496002086 metal binding site [ion binding]; metal-binding site 218496002087 Ribulose-phosphate 3 epimerase family Score = 217.1 E-value = 1.8e-62 218496002088 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 218496002089 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 218496002090 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 218496002091 Substrate binding site [chemical binding]; other site 218496002092 Cupin domain; Region: Cupin_2; cl09118 218496002093 Mannose-6-phosphate isomerase Score = 34.0 E-value = 6.3e-09 218496002094 Nucleotidyl transferase Score = 156.0 E-value = 4.6e-44 218496002095 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.256 between residues 42 and 43; signal peptide 218496002096 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218496002097 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218496002098 Phosphate-binding protein Score = 249.1 E-value = 4.3e-72 218496002099 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.362 between residues 37 and 38; signal peptide 218496002100 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 218496002101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 218496002102 dimer interface [polypeptide binding]; other site 218496002103 conserved gate region; other site 218496002104 putative PBP binding loops; other site 218496002105 ABC-ATPase subunit interface; other site 218496002106 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 5-27, 59-81, 101-123, 147-169, 226-248 and 263-285 218496002107 Binding-protein-dependent transport systems inner membrane component Score = 40.2 E-value = 3.3e-09 218496002108 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218496002109 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.390 between residues 46 and 47; signal peptide 218496002110 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 218496002111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 218496002112 dimer interface [polypeptide binding]; other site 218496002113 conserved gate region; other site 218496002114 putative PBP binding loops; other site 218496002115 ABC-ATPase subunit interface; other site 218496002116 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 21-43, 77-99, 111-133, 143-162, 190-212 and 265-287 218496002117 Binding-protein-dependent transport systems inner membrane component Score = 67.2 E-value = 2.5e-17 218496002118 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218496002119 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 218496002120 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 218496002121 Walker A/P-loop; other site 218496002122 ATP binding site [chemical binding]; other site 218496002123 Q-loop/lid; other site 218496002124 ABC transporter signature motif; other site 218496002125 Walker B; other site 218496002126 D-loop; other site 218496002127 H-loop/switch region; other site 218496002128 ABC transporter Score = 208.9 E-value = 5.3e-60 218496002129 PS00017 ATP/GTP-binding site motif A (P-loop). 218496002130 PS00211 ABC transporters family signature. 218496002131 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 218496002132 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 218496002133 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 218496002134 active site 218496002135 HIGH motif; other site 218496002136 KMSK motif region; other site 218496002137 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 218496002138 tRNA binding surface [nucleotide binding]; other site 218496002139 anticodon binding site; other site 218496002140 Arginyl tRNA synthetase N terminal domain Score = 52.6 E-value = 6.1e-13 218496002141 tRNA synthetases class I (R) Score = 236.7 E-value = 2.3e-68 218496002142 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 218496002143 CarD-like transcriptional regulator Score = 192.9 E-value = 3.6e-55 218496002144 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.925) with cleavage site probability 0.894 between residues 25 and 26; signal peptide 218496002145 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 218496002146 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 218496002147 substrate binding site [chemical binding]; other site 218496002148 dimer interface [polypeptide binding]; other site 218496002149 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 218496002150 homotrimer interaction site [polypeptide binding]; other site 218496002151 zinc binding site [ion binding]; other site 218496002152 CDP-binding sites; other site 218496002153 Uncharacterized protein family UPF0007 Score = 103.3 E-value = 3.4e-28 218496002154 YgbB family Score = 130.0 E-value = 3.2e-36 218496002155 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 218496002156 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 218496002157 active site 218496002158 HIGH motif; other site 218496002159 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 218496002160 KMSKS motif; other site 218496002161 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 218496002162 tRNA synthetases class I (C) Score = 452.2 E-value = 3.2e-133 218496002163 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 218496002164 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 218496002165 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 218496002166 SpoU rRNA Methylase family Score = 136.3 E-value = 4e-38 218496002167 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.996 between residues 61 and 62; signal peptide 218496002168 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 218496002169 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 32-54 218496002170 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 20-38, 45-67 and 94-116 218496002171 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 218496002172 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 218496002173 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 218496002174 Glucose-6-phosphate dehydrogenase, C-terminal domain Score = 417.0 E-value = 1.3e-122 218496002175 Glucose-6-phosphate dehydrogenase, NAD binding domain Score = 128.8 E-value = 6.9e-36 218496002176 PS00069 Glucose-6-phosphate dehydrogenase active site. 218496002177 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 218496002178 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 218496002179 Phosphoglucose isomerase Score = -117.8 E-value = 6.2e-08 218496002180 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 218496002181 putative active site [active] 218496002182 catalytic residue [active] 218496002183 Transaldolase Score = 289.2 E-value = 3.7e-84 218496002184 PS01054 Transaldolase signature 1. 218496002185 transketolase; Reviewed; Region: PRK05899 218496002186 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 218496002187 TPP-binding site [chemical binding]; other site 218496002188 dimer interface [polypeptide binding]; other site 218496002189 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 218496002190 PYR/PP interface [polypeptide binding]; other site 218496002191 dimer interface [polypeptide binding]; other site 218496002192 TPP binding site [chemical binding]; other site 218496002193 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218496002194 Transketolase, C-terminal domain Score = 14.2 E-value = 5.4e-05 218496002195 Transketolase, pyridine binding domain Score = 233.3 E-value = 2.5e-67 218496002196 Transketolase, thiamine diphosphate binding domain Score = 544.9 E-value = 3.9e-161 218496002197 PS00801 Transketolase signature 1. 218496002198 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.934) with cleavage site probability 0.599 between residues 61 and 62; signal peptide 218496002199 UbiA prenyltransferase family; Region: UbiA; cl00337 218496002200 9 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 21-43, 47-69, 90-112, 116-138, 145-167, 171-193, 213-235, 240-262 and 275-297 218496002201 UbiA prenyltransferase family Score = 210.5 E-value = 1.8e-60 218496002202 PS00943 UbiA prenyltransferase family signature. 218496002203 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 218496002204 Cytochrome oxidase assembly protein Score = -15.1 E-value = 5.3e-06 218496002205 8 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 48-70, 105-122, 129-151, 161-183, 195-217, 237-259, 272-291 and 296-315 218496002206 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 218496002207 FeS assembly protein SufB; Region: sufB; TIGR01980 218496002208 Uncharacterized protein family (UPF0051) Score = 450.0 E-value = 1.4e-132 218496002209 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 218496002210 Uncharacterized protein family (UPF0051) Score = 148.0 E-value = 1.2e-41 218496002211 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 218496002212 [2Fe-2S] cluster binding site [ion binding]; other site 218496002213 Rieske [2Fe-2S] domain Score = 65.5 E-value = 8.2e-17 218496002214 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 218496002215 FeS assembly ATPase SufC; Region: sufC; TIGR01978 218496002216 Walker A/P-loop; other site 218496002217 ATP binding site [chemical binding]; other site 218496002218 Q-loop/lid; other site 218496002219 ABC transporter signature motif; other site 218496002220 Walker B; other site 218496002221 D-loop; other site 218496002222 H-loop/switch region; other site 218496002223 ABC transporter Score = 101.6 E-value = 1.1e-27 218496002224 PS00017 ATP/GTP-binding site motif A (P-loop). 218496002225 Domain of unknown function DUF59; Region: DUF59; cl00941 218496002226 Domain of unknown function DUF59 Score = 85.9 E-value = 5.7e-23 218496002227 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.899) with cleavage site probability 0.455 between residues 46 and 47; signal peptide 218496002228 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 218496002229 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 21-43 and 230-252 218496002230 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 218496002231 catalytic residue [active] 218496002232 putative FPP diphosphate binding site; other site 218496002233 putative FPP binding hydrophobic cleft; other site 218496002234 dimer interface [polypeptide binding]; other site 218496002235 putative IPP diphosphate binding site; other site 218496002236 Putative undecaprenyl diphosphate synthase Score = 189.7 E-value = 3.4e-54 218496002237 PS01066 Undecaprenyl pyrophosphate synthetase family signature. 218496002238 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 218496002239 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 218496002240 Walker A/P-loop; other site 218496002241 ATP binding site [chemical binding]; other site 218496002242 Q-loop/lid; other site 218496002243 ABC transporter signature motif; other site 218496002244 Walker B; other site 218496002245 D-loop; other site 218496002246 H-loop/switch region; other site 218496002247 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 218496002248 ABC transporter Score = 154.1 E-value = 1.7e-43 218496002249 PS00017 ATP/GTP-binding site motif A (P-loop). 218496002250 ABC transporter Score = 68.9 E-value = 7.5e-18 218496002251 PS00211 ABC transporters family signature. 218496002252 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.414 between residues 26 and 27; signal peptide 218496002253 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 218496002254 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 218496002255 TM-ABC transporter signature motif; other site 218496002256 11 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 5-27, 37-59, 66-83, 88-107, 109-131, 161-183, 204-226, 231-250, 279-298, 318-340 and 352-374 218496002257 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 218496002258 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.459 between residues 34 and 35; signal peptide 218496002259 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 218496002260 putative ligand binding site [chemical binding]; other site 218496002261 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218496002262 Periplasmic binding proteins and sugar binding domain of the LacI family Score = -36.0 E-value = 0.0031 218496002263 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.788) with cleavage site probability 0.466 between residues 26 and 27; signal peptide 218496002264 Beta-lactamase; Region: Beta-lactamase; cl01009 218496002265 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 7-26 218496002266 D-alanyl-D-alanine carboxypeptidase Score = -22.6 E-value = 5.3e-09 218496002267 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 218496002268 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 218496002269 catalytic Zn binding site [ion binding]; other site 218496002270 structural Zn binding site [ion binding]; other site 218496002271 NAD(P) binding site [chemical binding]; other site 218496002272 Zinc-binding dehydrogenase Score = 238.1 E-value = 8.8e-69 218496002273 PS00059 Zinc-containing alcohol dehydrogenases signature. 218496002274 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 218496002275 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 218496002276 active site 218496002277 TatD related DNase Score = 247.1 E-value = 1.7e-71 218496002278 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.479 between residues 44 and 45 218496002279 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 15-37 and 200-222 218496002280 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 218496002281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218496002282 NAD(P) binding site [chemical binding]; other site 218496002283 active site 218496002284 short chain dehydrogenase Score = -3.1 E-value = 3e-07 218496002285 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 218496002286 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 13-32, 70-92, 101-123, 154-176, 188-205 and 209-231 218496002287 MttB family UPF0032 Score = 77.0 E-value = 2.8e-20 218496002288 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 218496002289 mttA/Hcf106 family Score = 34.0 E-value = 2.4e-07 218496002290 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 5-22 218496002291 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.759 between residues 27 and 28; signal peptide 218496002292 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 218496002293 FKBP-type peptidyl-prolyl cis-trans isomerase Score = 108.2 E-value = 1.1e-29 218496002294 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 218496002295 FKBP-type peptidyl-prolyl cis-trans isomerase Score = 0.2 E-value = 4.6 218496002296 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218496002297 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 218496002298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 218496002299 PAC2 family; Region: PAC2; cl00847 218496002300 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 218496002301 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 218496002302 active site 218496002303 HIGH motif; other site 218496002304 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218496002305 active site 218496002306 KMSKS motif; other site 218496002307 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 218496002308 tRNA synthetases class I (C) Score = 16.7 E-value = 1.1e-14 218496002309 Bacitracin resistance protein BacA; Region: BacA; cl00858 218496002310 7 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 5-27, 37-59, 94-116, 126-148, 197-219, 229-251 and 258-277 218496002311 Bacitracin resistance protein BacA Score = 239.2 E-value = 4.1e-69 218496002312 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 218496002313 Ribosomal protein L31 Score = 74.1 E-value = 2.1e-19 218496002314 PS01143 Ribosomal protein L31 signature. 218496002315 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 218496002316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218496002317 NAD(P) binding site [chemical binding]; other site 218496002318 active site 218496002319 short chain dehydrogenase Score = 264.4 E-value = 1.1e-76 218496002320 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817 218496002321 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218496002322 putative ADP-binding pocket [chemical binding]; other site 218496002323 Glycosyl transferases group 1 Score = 132.9 E-value = 4e-37 218496002324 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.574 between residues 52 and 53; signal peptide 218496002325 Protein of unknown function (DUF803); Region: DUF803; pfam05653 218496002326 8 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 13-32, 37-59, 80-99, 109-126, 133-155, 160-182, 195-217 and 227-249 218496002327 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 218496002328 active site 218496002329 catalytic residues [active] 218496002330 metal binding site [ion binding]; metal-binding site 218496002331 Polypeptide deformylase Score = 170.8 E-value = 1.6e-48 218496002332 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 218496002333 7 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 13-35, 51-73, 88-110, 117-139, 173-195, 208-226 and 241-263 218496002334 Prolipoprotein diacylglyceryl transferase Score = 103.0 E-value = 4.1e-28 218496002335 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218496002336 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 218496002337 putative active site [active] 218496002338 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Score = -62.5 E-value = 0.00057 218496002339 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 218496002340 dimer interface [polypeptide binding]; other site 218496002341 substrate binding site [chemical binding]; other site 218496002342 metal binding sites [ion binding]; metal-binding site 218496002343 Inorganic pyrophosphatase Score = 199.5 E-value = 3.6e-57 218496002344 PS00387 Inorganic pyrophosphatase signature. 218496002345 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.991 between residues 23 and 24; signal peptide 218496002346 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 152-171 218496002347 Preprotein translocase SecG subunit; Region: SecG; cl09123 218496002348 Preprotein translocase SecG subunit Score = 69.9 E-value = 3.7e-18 218496002349 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 20-42 and 75-94 218496002350 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 218496002351 substrate binding site [chemical binding]; other site 218496002352 dimer interface [polypeptide binding]; other site 218496002353 catalytic triad [active] 218496002354 Triosephosphate isomerase Score = 87.4 E-value = 2.1e-23 218496002355 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 218496002356 substrate binding site [chemical binding]; other site 218496002357 hinge regions; other site 218496002358 ADP binding site [chemical binding]; other site 218496002359 catalytic site [active] 218496002360 Phosphoglycerate kinase Score = 483.6 E-value = 1.1e-142 218496002361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218496002362 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 218496002363 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 218496002364 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Score = 324.2 E-value = 1.1e-94 218496002365 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 218496002366 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Score = 265.2 E-value = 6.3e-77 218496002367 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 218496002368 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 218496002369 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 218496002370 Iron/manganese superoxide dismutases, C-terminal domain Score = 147.4 E-value = 1.8e-41 218496002371 PS00088 Manganese and iron superoxide dismutases signature. 218496002372 Iron/manganese superoxide dismutases, alpha-hairpin domain Score = 150.6 E-value = 2e-42 218496002373 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 218496002374 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 218496002375 Uncharacterized BCR, COG1481 Score = 107.9 E-value = 1.4e-29 218496002376 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 218496002377 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 218496002378 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 218496002379 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 218496002380 UvrB/uvrC motif Score = 30.2 E-value = 3.4e-06 218496002381 Endo/excinuclease amino terminal domain Score = 75.6 E-value = 7.2e-20 218496002382 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 218496002383 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 218496002384 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 218496002385 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 218496002386 ABC transporter Score = 88.6 E-value = 9e-24 218496002387 PS00211 ABC transporters family signature. 218496002388 PS00017 ATP/GTP-binding site motif A (P-loop). 218496002389 ABC transporter Score = 5.5 E-value = 1.4e-06 218496002390 PS00211 ABC transporters family signature. 218496002391 PS00017 ATP/GTP-binding site motif A (P-loop). 218496002392 excinuclease ABC subunit B; Provisional; Region: PRK05298 218496002393 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218496002394 ATP binding site [chemical binding]; other site 218496002395 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218496002396 nucleotide binding region [chemical binding]; other site 218496002397 ATP-binding site [chemical binding]; other site 218496002398 Ultra-violet resistance protein B; Region: UvrB; pfam12344 218496002399 UvrB/uvrC motif; Region: UVR; pfam02151 218496002400 UvrB/uvrC motif Score = 46.8 E-value = 3.3e-11 218496002401 Helicase conserved C-terminal domain Score = 68.8 E-value = 8.3e-18 218496002402 PS00017 ATP/GTP-binding site motif A (P-loop). 218496002403 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 218496002404 CoA-binding site [chemical binding]; other site 218496002405 ATP-binding [chemical binding]; other site 218496002406 Dephospho-CoA kinase Score = 26.4 E-value = 1.2e-13 218496002407 PS00017 ATP/GTP-binding site motif A (P-loop). 218496002408 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 218496002409 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 218496002410 RNA binding site [nucleotide binding]; other site 218496002411 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 218496002412 RNA binding site [nucleotide binding]; other site 218496002413 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 218496002414 RNA binding site [nucleotide binding]; other site 218496002415 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 218496002416 S1 RNA binding domain Score = 80.0 E-value = 3.3e-21 218496002417 S1 RNA binding domain Score = 116.2 E-value = 4.5e-32 218496002418 S1 RNA binding domain Score = 62.7 E-value = 5.5e-16 218496002419 S1 RNA binding domain Score = 60.0 E-value = 3.6e-15 218496002420 5'-3' exonuclease; Region: 53EXOc; smart00475 218496002421 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 218496002422 active site 218496002423 metal binding site 1 [ion binding]; metal-binding site 218496002424 putative 5' ssDNA interaction site; other site 218496002425 metal binding site 3; metal-binding site 218496002426 metal binding site 2 [ion binding]; metal-binding site 218496002427 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 218496002428 putative DNA binding site [nucleotide binding]; other site 218496002429 putative metal binding site [ion binding]; other site 218496002430 5'-3' exonuclease, C-terminal SAM fold Score = 85.8 E-value = 6.1e-23 218496002431 5'-3' exonuclease, N-terminal resolvase-like domain Score = 213.0 E-value = 3.2e-61 218496002432 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 218496002433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 218496002434 active site 218496002435 phosphorylation site [posttranslational modification] 218496002436 intermolecular recognition site; other site 218496002437 dimerization interface [polypeptide binding]; other site 218496002438 ANTAR domain; Region: ANTAR; pfam03861 218496002439 ANTAR domain Score = 66.3 E-value = 4.7e-17 218496002440 Response regulator receiver domain Score = 108.9 E-value = 7.1e-30 218496002441 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 218496002442 pyruvate kinase; Provisional; Region: PRK06247 218496002443 domain interfaces; other site 218496002444 active site 218496002445 Pyruvate kinase, alpha/beta domain Score = 28.6 E-value = 7.4e-08 218496002446 Pyruvate kinase, barrel domain Score = 454.1 E-value = 8.5e-134 218496002447 PS00110 Pyruvate kinase active site signature. 218496002448 NlpC/P60 family; Region: NLPC_P60; cl11438 218496002449 NLP/P60 family Score = 123.3 E-value = 3.1e-34 218496002450 DNA primase; Validated; Region: dnaG; PRK05667 218496002451 CHC2 zinc finger; Region: zf-CHC2; cl02597 218496002452 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 218496002453 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 218496002454 active site 218496002455 metal binding site [ion binding]; metal-binding site 218496002456 interdomain interaction site; other site 218496002457 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 218496002458 Toprim domain Score = 49.3 E-value = 6e-12 218496002459 CHC2 zinc finger Score = 166.6 E-value = 2.9e-47 218496002460 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 218496002461 HD domain Score = 42.6 E-value = 6.1e-10 218496002462 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 218496002463 catalytic residue [active] 218496002464 putative FPP diphosphate binding site; other site 218496002465 putative FPP binding hydrophobic cleft; other site 218496002466 dimer interface [polypeptide binding]; other site 218496002467 putative IPP diphosphate binding site; other site 218496002468 Putative undecaprenyl diphosphate synthase Score = 348.9 E-value = 4e-102 218496002469 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 218496002470 Recombination protein O N terminal; Region: RecO_N; pfam11967 218496002471 Recombination protein O C terminal; Region: RecO_C; pfam02565 218496002472 Recombination protein O Score = 69.2 E-value = 6.2e-18 218496002473 GTPase Era; Reviewed; Region: era; PRK00089 218496002474 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 218496002475 G1 box; other site 218496002476 GTP/Mg2+ binding site [chemical binding]; other site 218496002477 Switch I region; other site 218496002478 G2 box; other site 218496002479 Switch II region; other site 218496002480 G3 box; other site 218496002481 G4 box; other site 218496002482 G5 box; other site 218496002483 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 218496002484 PS00017 ATP/GTP-binding site motif A (P-loop). 218496002485 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 218496002486 Uncharacterized protein family UPF0054 Score = 89.1 E-value = 6.4e-24 218496002487 PS01306 Uncharacterized protein family UPF0054 signature. 218496002488 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 218496002489 nucleotide binding site/active site [active] 218496002490 HIT family signature motif; other site 218496002491 catalytic residue [active] 218496002492 HIT family Score = 81.1 E-value = 1.6e-21 218496002493 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 218496002494 Protein of unknown function (DUF558) Score = 66.2 E-value = 5e-17 218496002495 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 218496002496 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 218496002497 HSP70 interaction site [polypeptide binding]; other site 218496002498 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 218496002499 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 218496002500 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 218496002501 DnaJ C terminal region Score = 120.5 E-value = 2.2e-33 218496002502 DnaJ central domain (4 repeats) Score = 65.4 E-value = 8.5e-17 218496002503 DnaJ domain Score = 8.5 E-value = 8e-05 218496002504 PS00636 Nt-dnaJ domain signature. 218496002505 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 218496002506 GTP-binding protein LepA; Provisional; Region: PRK05433 218496002507 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 218496002508 G1 box; other site 218496002509 putative GEF interaction site [polypeptide binding]; other site 218496002510 GTP/Mg2+ binding site [chemical binding]; other site 218496002511 Switch I region; other site 218496002512 G2 box; other site 218496002513 G3 box; other site 218496002514 Switch II region; other site 218496002515 G4 box; other site 218496002516 G5 box; other site 218496002517 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 218496002518 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 218496002519 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 218496002520 Elongation factor G C-terminus Score = 129.1 E-value = 5.8e-36 218496002521 Elongation factor Tu domain 2 Score = 51.2 E-value = 1.6e-12 218496002522 Elongation factor Tu GTP binding domain Score = 222.4 E-value = 4.7e-64 218496002523 PS00301 GTP-binding elongation factors signature. 218496002524 PS00017 ATP/GTP-binding site motif A (P-loop). 218496002525 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 218496002526 Ribosomal protein S20 Score = 100.1 E-value = 3e-27 218496002527 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 218496002528 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 218496002529 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 218496002530 synthetase active site [active] 218496002531 NTP binding site [chemical binding]; other site 218496002532 metal binding site [ion binding]; metal-binding site 218496002533 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 218496002534 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 218496002535 ACT domain Score = 39.8 E-value = 4.3e-09 218496002536 TGS domain Score = 98.2 E-value = 1.2e-26 218496002537 Region found in RelA / SpoT proteins Score = 218.6 E-value = 6.5e-63 218496002538 HD domain Score = 34.8 E-value = 1.4e-07 218496002539 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl14635 218496002540 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 218496002541 Protein export membrane protein; Region: SecD_SecF; cl14618 218496002542 Protein export membrane protein Score = 270.2 E-value = 1.9e-78 218496002543 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 26-48, 141-160, 165-187, 192-214, 248-270 and 280-302 218496002544 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 218496002545 Protein export membrane protein; Region: SecD_SecF; cl14618 218496002546 Protein export membrane protein Score = -55.5 E-value = 3.3e-06 218496002547 5 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 342-361, 366-388, 398-420, 453-470 and 474-496 218496002548 Preprotein translocase subunit; Region: YajC; cl00806 218496002549 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 4-21 218496002550 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 218496002551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 218496002552 Walker A motif; other site 218496002553 ATP binding site [chemical binding]; other site 218496002554 Walker B motif; other site 218496002555 arginine finger; other site 218496002556 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 218496002557 ATPase family associated with various cellular activities (AAA) Score = 97.7 E-value = 1.6e-26 218496002558 PS00017 ATP/GTP-binding site motif A (P-loop). 218496002559 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14604 218496002560 RuvA N terminal domain; Region: RuvA_N; pfam01330 218496002561 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 218496002562 RuvA central domain II Score = 77.5 E-value = 2e-20 218496002563 RuvA N terminal domain Score = 24.1 E-value = 1.3e-08 218496002564 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 218496002565 active site 218496002566 putative DNA-binding cleft [nucleotide binding]; other site 218496002567 dimer interface [polypeptide binding]; other site 218496002568 Crossover junction endodeoxyribonuclease RuvC Score = 108.8 E-value = 7.6e-30 218496002569 Domain of unknown function DUF28; Region: DUF28; cl00361 218496002570 Domain of unknown function DUF28 Score = 320.5 E-value = 1.4e-93 218496002571 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 218496002572 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 218496002573 predicted active site [active] 218496002574 catalytic triad [active] 218496002575 SNO glutamine amidotransferase family Score = 207.8 E-value = 1.2e-59 218496002576 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 218496002577 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 218496002578 active site 218496002579 multimer interface [polypeptide binding]; other site 218496002580 SOR/SNZ family Score = 405.8 E-value = 3e-119 218496002581 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 218496002582 nucleotide binding site/active site [active] 218496002583 HIT family signature motif; other site 218496002584 catalytic residue [active] 218496002585 HIT family Score = 42.0 E-value = 9.8e-10 218496002586 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 218496002587 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 218496002588 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 218496002589 active site 218496002590 dimer interface [polypeptide binding]; other site 218496002591 motif 1; other site 218496002592 motif 2; other site 218496002593 motif 3; other site 218496002594 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 218496002595 anticodon binding site; other site 218496002596 Anticodon binding domain Score = 63.4 E-value = 3.3e-16 218496002597 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218496002598 tRNA synthetase class II core domain (G, H, P, S and T) Score = 127.3 E-value = 2e-35 218496002599 glutamine synthetase, type I; Region: GlnA; TIGR00653 218496002600 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 218496002601 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 218496002602 Glutamine synthetase, beta-Grasp domain Score = 105.2 E-value = 8.9e-29 218496002603 Glutamine synthetase, catalytic domain Score = 486.0 E-value = 2e-143 218496002604 PS00181 Glutamine synthetase putative ATP-binding region signature. 218496002605 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 218496002606 oligomerization interface [polypeptide binding]; other site 218496002607 active site 218496002608 metal binding site [ion binding]; metal-binding site 218496002609 Ketopantoate hydroxymethyltransferase Score = 376.3 E-value = 2.2e-110 218496002610 methionine aminopeptidase; Reviewed; Region: PRK07281 218496002611 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 218496002612 active site 218496002613 metallopeptidase family M24 Score = 223.2 E-value = 2.7e-64 218496002614 PS00680 Methionine aminopeptidase subfamily 1 signature. 218496002615 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 218496002616 Putative zinc ribbon domain; Region: DUF164; pfam02591 218496002617 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 218496002618 Uncharacterized ACR, COG1579 Score = -16.3 E-value = 5.9e-06 218496002619 Uncharacterized conserved protein [Function unknown]; Region: COG0327 218496002620 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 218496002621 Domain of unknown function DUF34 Score = 118.5 E-value = 8.9e-33 218496002622 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 218496002623 dimer interface [polypeptide binding]; other site 218496002624 catalytic triad [active] 218496002625 AhpC/TSA family Score = 123.8 E-value = 2.3e-34 218496002626 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 218496002627 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 218496002628 dimer interface [polypeptide binding]; other site 218496002629 TPP-binding site [chemical binding]; other site 218496002630 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 218496002631 Acyl transferase domain; Region: Acyl_transf_1; cl08282 218496002632 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 218496002633 Acyl transferase domain Score = -66.0 E-value = 3.8e-07 218496002634 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 218496002635 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 218496002636 dimer interface [polypeptide binding]; other site 218496002637 active site 218496002638 CoA binding pocket [chemical binding]; other site 218496002639 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 218496002640 Phosphopantetheine attachment site; Region: PP-binding; cl09936 218496002641 Phosphopantetheine attachment site Score = 67.3 E-value = 2.4e-17 218496002642 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 218496002643 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 218496002644 dimer interface [polypeptide binding]; other site 218496002645 active site 218496002646 Beta-ketoacyl synthase, N-terminal domain Score = 174.8 E-value = 1e-49 218496002647 Beta-ketoacyl synthase, C-terminal domain Score = 185.0 E-value = 8.8e-53 218496002648 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 218496002649 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 218496002650 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 218496002651 heme bH binding site [chemical binding]; other site 218496002652 intrachain domain interface; other site 218496002653 heme bL binding site [chemical binding]; other site 218496002654 interchain domain interface [polypeptide binding]; other site 218496002655 Qo binding site; other site 218496002656 9 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 48-70, 118-140, 149-171, 181-203, 216-238, 272-294, 339-361, 381-403 and 415-437 218496002657 Cytochrome b(N-terminal)/b6/petB Score = 57.5 E-value = 2.1e-14 218496002658 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 218496002659 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 218496002660 iron-sulfur cluster [ion binding]; other site 218496002661 [2Fe-2S] cluster binding site [ion binding]; other site 218496002662 Rieske [2Fe-2S] domain Score = 37.9 E-value = 1.6e-08 218496002663 PS00200 Rieske iron-sulfur protein signature 2. 218496002664 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 32-54, 69-91 and 138-160 218496002665 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 218496002666 Cytochrome c; Region: Cytochrom_C; cl11414 218496002667 Cytochrome c; Region: Cytochrom_C; cl11414 218496002668 Cytochrome c; Region: Cytochrom_C; cl11414 218496002669 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 24-46 and 248-270 218496002670 Cytochrome c Score = 23.3 E-value = 0.00013 218496002671 PS00190 Cytochrome c family heme-binding site signature. 218496002672 Cytochrome c Score = 9.1 E-value = 0.0035 218496002673 PS00190 Cytochrome c family heme-binding site signature. 218496002674 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 218496002675 Subunit I/III interface [polypeptide binding]; other site 218496002676 Cytochrome c oxidase subunit III Score = -92.5 E-value = 9e-12 218496002677 5 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 19-41, 61-83, 104-126, 141-163 and 184-206 218496002678 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 218496002679 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 7-29, 33-55, 81-103 and 108-130 218496002680 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 218496002681 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 218496002682 D-pathway; other site 218496002683 Putative ubiquinol binding site [chemical binding]; other site 218496002684 Low-spin heme (heme b) binding site [chemical binding]; other site 218496002685 Putative water exit pathway; other site 218496002686 Binuclear center (heme o3/CuB) [ion binding]; other site 218496002687 K-pathway; other site 218496002688 Putative proton exit pathway; other site 218496002689 12 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 31-53, 76-98, 118-140, 160-182, 203-225, 248-270, 282-304, 309-331, 351-373, 388-410, 422-444 and 464-486 218496002690 Cytochrome C and Quinol oxidase polypeptide I Score = 764.9 E-value = 2.3e-227 218496002691 PS00152 ATP synthase alpha and beta subunits signature. 218496002692 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 218496002693 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.847 between residues 47 and 48; signal peptide 218496002694 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 218496002695 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 218496002696 Cytochrome C oxidase subunit II, periplasmic domain Score = 55.4 E-value = 8.5e-14 218496002697 PS00078 CO II and nitrous oxide reductase dinuclear copper centers signature. 218496002698 Cytochrome C oxidase subunit II, transmembrane domain Score = -25.5 E-value = 0.057 218496002699 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 13-35, 65-87 and 104-126 218496002700 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 218496002701 HesB-like domain Score = 169.9 E-value = 3.1e-48 218496002702 PS01152 Hypothetical hesB/yadR/yfhF family signature. 218496002703 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 218496002704 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 218496002705 active site 218496002706 metal binding site [ion binding]; metal-binding site 218496002707 dimer interface [polypeptide binding]; other site 218496002708 Peptidase family M20/M25/M40 Score = 138.9 E-value = 6.6e-39 218496002709 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 218496002710 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 76-98 and 102-124 218496002711 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 218496002712 RNA/DNA hybrid binding site [nucleotide binding]; other site 218496002713 active site 218496002714 RNase H Score = 128.8 E-value = 7.2e-36 218496002715 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 218496002716 quinone interaction residues [chemical binding]; other site 218496002717 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 218496002718 active site 218496002719 catalytic residues [active] 218496002720 FMN binding site [chemical binding]; other site 218496002721 substrate binding site [chemical binding]; other site 218496002722 Dihydroorotate dehydrogenase Score = 339.3 E-value = 3.1e-99 218496002723 PS00912 Dihydroorotate dehydrogenase signature 2. 218496002724 PS00911 Dihydroorotate dehydrogenase signature 1. 218496002725 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 218496002726 ATP cone domain; Region: ATP-cone; pfam03477 218496002727 ATP cone domain Score = 92.1 E-value = 8.1e-25 218496002728 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 218496002729 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 218496002730 DNA binding residues [nucleotide binding] 218496002731 dimer interface [polypeptide binding]; other site 218496002732 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 218496002733 phosphopeptide binding site; other site 218496002734 FHA domain Score = 59.3 E-value = 5.9e-15 218496002735 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 53-75, 80-102 and 115-137 218496002736 cell division protein FtsQ; Provisional; Region: PRK05529 218496002737 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.966) with cleavage site probability 0.264 between residues 59 and 60; signal peptide 218496002738 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 218496002739 Cell division protein FtsQ; Region: FtsQ; pfam03799 218496002740 Cell division protein FtsQ Score = 43.8 E-value = 2.7e-10 218496002741 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 35-57 218496002742 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 218496002743 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218496002744 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218496002745 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218496002746 Mur ligase family, glutamate ligase domain Score = 78.9 E-value = 7.6e-21 218496002747 Mur ligase family, catalytic domain Score = 85.9 E-value = 5.7e-23 218496002748 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 218496002749 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 218496002750 active site 218496002751 homodimer interface [polypeptide binding]; other site 218496002752 Glycosyltransferase family 28 C-terminal domain Score = 92.1 E-value = 8.1e-25 218496002753 Glycosyltransferase family 28 N-terminal domain Score = 188.5 E-value = 7.4e-54 218496002754 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.447 between residues 33 and 34; signal peptide 218496002755 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 218496002756 Cell cycle protein Score = 238.8 E-value = 5.6e-69 218496002757 8 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 12-34, 44-66, 73-95, 142-159, 166-188, 276-298, 310-332 and 342-364 218496002758 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 218496002759 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 218496002760 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218496002761 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218496002762 Mur ligase family, glutamate ligase domain Score = 35.3 E-value = 9.7e-08 218496002763 Mur ligase family, catalytic domain Score = 80.2 E-value = 3e-21 218496002764 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 218496002765 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218496002766 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218496002767 Mur ligase family, glutamate ligase domain Score = 59.0 E-value = 7.2e-15 218496002768 Mur ligase family, catalytic domain Score = 63.4 E-value = 3.5e-16 218496002769 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 218496002770 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 218496002771 Mg++ binding site [ion binding]; other site 218496002772 putative catalytic motif [active] 218496002773 putative substrate binding site [chemical binding]; other site 218496002774 10 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 4-26, 52-74, 79-96, 117-139, 159-181, 194-216, 244-261, 268-290, 294-316 and 342-364 218496002775 Glycosyl transferase Score = 134.3 E-value = 1.6e-37 218496002776 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 218496002777 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218496002778 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218496002779 Mur ligase family, glutamate ligase domain Score = 14.2 E-value = 0.00088 218496002780 Mur ligase family, catalytic domain Score = 120.7 E-value = 1.9e-33 218496002781 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 218496002782 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.854 between residues 34 and 35; signal peptide 218496002783 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 218496002784 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 218496002785 Penicillin binding protein transpeptidase domain Score = 184.2 E-value = 1.5e-52 218496002786 PS00017 ATP/GTP-binding site motif A (P-loop). 218496002787 Penicillin-binding Protein dimerisation domain Score = 97.2 E-value = 2.3e-26 218496002788 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 7-29 218496002789 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.479 between residues 39 and 40; signal peptide 218496002790 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 13-35 218496002791 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 218496002792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 218496002793 MraW methylase family Score = 427.7 E-value = 7.6e-126 218496002794 PS00107 Protein kinases ATP-binding region signature. 218496002795 cell division protein MraZ; Reviewed; Region: PRK00326 218496002796 MraZ protein; Region: MraZ; pfam02381 218496002797 MraZ protein; Region: MraZ; pfam02381 218496002798 Domain of unknown function UPF0040 family Score = 69.6 E-value = 4.7e-18 218496002799 Domain of unknown function UPF0040 family Score = 51.8 E-value = 1.1e-12 218496002800 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 78-100 and 115-137 218496002801 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 218496002802 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 54-73 and 77-99 218496002803 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 218496002804 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 218496002805 substrate binding pocket [chemical binding]; other site 218496002806 chain length determination region; other site 218496002807 substrate-Mg2+ binding site; other site 218496002808 catalytic residues [active] 218496002809 aspartate-rich region 1; other site 218496002810 active site lid residues [active] 218496002811 aspartate-rich region 2; other site 218496002812 Polyprenyl synthetase Score = 45.7 E-value = 4.6e-11 218496002813 PS00723 Polyprenyl synthetases signature 1. 218496002814 Catalytic domain of Protein Kinases; Region: PKc; cd00180 218496002815 active site 218496002816 ATP binding site [chemical binding]; other site 218496002817 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 218496002818 substrate binding site [chemical binding]; other site 218496002819 activation loop (A-loop); other site 218496002820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 218496002821 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 218496002822 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 218496002823 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 218496002824 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 218496002825 Protein kinase domain Score = 208.8 E-value = 6e-60 218496002826 PS00108 Serine/Threonine protein kinases active-site signature. 218496002827 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 309-331 218496002828 PASTA domain Score = 61.1 E-value = 1.7e-15 218496002829 PASTA domain Score = 36.8 E-value = 3.4e-08 218496002830 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 218496002831 Class-II DAHP synthetase family Score = 803.9 E-value = 4.3e-239 218496002832 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 218496002833 putative acyl-acceptor binding pocket; other site 218496002834 Acyltransferase Score = 115.9 E-value = 5.5e-32 218496002835 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 218496002836 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 218496002837 ROK family Score = 172.8 E-value = 4e-49 218496002838 WisP family N-Terminal Region; Region: WND; pfam07861 218496002839 Putative Ig domain; Region: He_PIG; cl09256 218496002840 Putative Ig domain; Region: He_PIG; cl09256 218496002841 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.819) with cleavage site probability 0.639 between residues 23 and 24 218496002842 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.967) with cleavage site probability 0.575 between residues 42 and 43; signal peptide 218496002843 BioY family; Region: BioY; cl00560 218496002844 BioY family Score = 96.2 E-value = 4.5e-26 218496002845 5 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 10-29, 49-71, 86-108, 120-142 and 157-179 218496002846 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 218496002847 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 218496002848 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 218496002849 HIGH motif; other site 218496002850 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 218496002851 active site 218496002852 KMSKS motif; other site 218496002853 tRNA synthetases class I (E and Q), catalytic domain Score = 315.1 E-value = 5.7e-92 218496002854 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 218496002855 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 218496002856 homodimer interface [polypeptide binding]; other site 218496002857 substrate-cofactor binding pocket; other site 218496002858 catalytic residue [active] 218496002859 Aminotransferase class IV Score = 342.1 E-value = 4.4e-100 218496002860 PS00770 Aminotransferases class-IV signature. 218496002861 ketol-acid reductoisomerase; Provisional; Region: PRK05479 218496002862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218496002863 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 218496002864 Acetohydroxy acid isomeroreductase, catalytic domain Score = 255.2 E-value = 6.3e-74 218496002865 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 218496002866 putative valine binding site [chemical binding]; other site 218496002867 dimer interface [polypeptide binding]; other site 218496002868 ACT domain Score = 58.7 E-value = 8.7e-15 218496002869 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 218496002870 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 218496002871 PYR/PP interface [polypeptide binding]; other site 218496002872 dimer interface [polypeptide binding]; other site 218496002873 TPP binding site [chemical binding]; other site 218496002874 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 218496002875 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 218496002876 TPP-binding site [chemical binding]; other site 218496002877 dimer interface [polypeptide binding]; other site 218496002878 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Score = 260.3 E-value = 1.9e-75 218496002879 PS00187 Thiamine pyrophosphate enzymes signature. 218496002880 Thiamine pyrophosphate enzyme, central domain Score = 192.3 E-value = 5.3e-55 218496002881 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain Score = 273.6 E-value = 1.8e-79 218496002882 Dehydratase family; Region: ILVD_EDD; cl00340 218496002883 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 218496002884 Dehydratase family Score = 972.8 E-value = 5.9e-290 218496002885 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 218496002886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 218496002887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 218496002888 Ribosomal RNA adenine dimethylase Score = 69.1 E-value = 6.4e-18 218496002889 PS01131 Ribosomal RNA adenine dimethylases signature. 218496002890 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.891 between residues 45 and 46; signal peptide 218496002891 WisP family N-Terminal Region; Region: WND; pfam07861 218496002892 Putative Ig domain; Region: He_PIG; cl09256 218496002893 Putative Ig domain; Region: He_PIG; cl09256 218496002894 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 21-43 218496002895 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 218496002896 SmpB-tmRNA interface; other site 218496002897 SmpB protein Score = 93.6 E-value = 2.7e-25 218496002898 PS01317 Protein smpB signature. 218496002899 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.848) with cleavage site probability 0.366 between residues 39 and 40; signal peptide 218496002900 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 218496002901 FtsX-like permease family; Region: FtsX; pfam02687 218496002902 Predicted permease Score = 66.1 E-value = 5.1e-17 218496002903 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 20-42, 183-205, 233-255 and 275-297 218496002904 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 218496002905 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 218496002906 Walker A/P-loop; other site 218496002907 ATP binding site [chemical binding]; other site 218496002908 Q-loop/lid; other site 218496002909 ABC transporter signature motif; other site 218496002910 Walker B; other site 218496002911 D-loop; other site 218496002912 H-loop/switch region; other site 218496002913 ABC transporter Score = 193.5 E-value = 2.3e-55 218496002914 PS00211 ABC transporters family signature. 218496002915 PS00017 ATP/GTP-binding site motif A (P-loop). 218496002916 peptide chain release factor 2; Validated; Region: prfB; PRK00578 218496002917 RF-1 domain; Region: RF-1; cl02875 218496002918 RF-1 domain; Region: RF-1; cl02875 218496002919 Peptidyl-tRNA hydrolase domain Score = 207.2 E-value = 1.8e-59 218496002920 PS00745 Prokaryotic-type class I peptide chain release factors signature. 218496002921 PCRF domain Score = 106.4 E-value = 3.8e-29 218496002922 Major Facilitator Superfamily; Region: MFS_1; pfam07690 218496002923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218496002924 putative substrate translocation pore; other site 218496002925 Sugar (and other) transporter Score = -112.4 E-value = 0.00074 218496002926 8 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 21-43, 53-70, 77-99, 114-136, 143-165, 255-277, 284-306 and 346-368 218496002927 aspartate carbamoyltransferase; Provisional; Region: PRK11891 218496002928 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 218496002929 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 218496002930 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Score = 51.3 E-value = 1.5e-12 218496002931 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Score = 157.9 E-value = 1.2e-44 218496002932 PS00097 Aspartate and ornithine carbamoyltransferases signature. 218496002933 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 87-109 218496002934 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.699) with cleavage site probability 0.428 between residues 52 and 53; signal peptide 218496002935 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 21-43 218496002936 TadE-like protein; Region: TadE; pfam07811 218496002937 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 30-52 218496002938 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.819) with cleavage site probability 0.657 between residues 41 and 42; signal peptide 218496002939 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 22-44 218496002940 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.964) with cleavage site probability 0.381 between residues 33 and 34; signal peptide 218496002941 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 218496002942 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 5-27, 97-119, 124-146 and 275-297 218496002943 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.637 between residues 32 and 33; signal peptide 218496002944 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 218496002945 5 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 10-32, 57-79, 83-105, 228-247 and 262-284 218496002946 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 218496002947 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 218496002948 ATP binding site [chemical binding]; other site 218496002949 Walker A motif; other site 218496002950 hexamer interface [polypeptide binding]; other site 218496002951 Walker B motif; other site 218496002952 Type II/IV secretion system protein Score = -81.6 E-value = 1.9e-05 218496002953 PS00017 ATP/GTP-binding site motif A (P-loop). 218496002954 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 218496002955 active site 218496002956 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 218496002957 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 218496002958 active site 218496002959 substrate binding site [chemical binding]; other site 218496002960 CoA binding site [chemical binding]; other site 218496002961 Bacterial transferase hexapeptide (four repeats) Score = 6.4 E-value = 7.9 218496002962 Bacterial transferase hexapeptide (four repeats) Score = 16.3 E-value = 0.052 218496002963 Bacterial transferase hexapeptide (four repeats) Score = 15.7 E-value = 0.076 218496002964 Bacterial transferase hexapeptide (four repeats) Score = 12.5 E-value = 0.71 218496002965 Bacterial transferase hexapeptide (four repeats) Score = 6.0 E-value = 8.9 218496002966 Bacterial transferase hexapeptide (four repeats) Score = 9.4 E-value = 3.2 218496002967 ribose-phosphate pyrophosphokinase; Region: ribP_PPkin; TIGR01251 218496002968 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 218496002969 PS00114 Phosphoribosyl pyrophosphate synthetase signature. 218496002970 Phosphoribosyl transferase domain Score = 99.4 E-value = 4.9e-27 218496002971 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 218496002972 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 218496002973 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 218496002974 GcpE protein Score = 694.6 E-value = 3.3e-206 218496002975 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 70-92, 102-124 and 201-223 218496002976 prolyl-tRNA synthetase; Provisional; Region: PRK09194 218496002977 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 218496002978 dimer interface [polypeptide binding]; other site 218496002979 motif 1; other site 218496002980 active site 218496002981 motif 2; other site 218496002982 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 218496002983 putative deacylase active site [active] 218496002984 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 218496002985 active site 218496002986 motif 3; other site 218496002987 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 218496002988 anticodon binding site; other site 218496002989 tRNA synthetase class II core domain (G, H, P, S and T) Score = 164.3 E-value = 1.5e-46 218496002990 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218496002991 Anticodon binding domain Score = 56.8 E-value = 3.3e-14 218496002992 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 218496002993 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 218496002994 DEAD-like helicases superfamily; Region: DEXDc; smart00487 218496002995 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218496002996 ATP binding site [chemical binding]; other site 218496002997 putative Mg++ binding site [ion binding]; other site 218496002998 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218496002999 nucleotide binding region [chemical binding]; other site 218496003000 ATP-binding site [chemical binding]; other site 218496003001 TRCF domain; Region: TRCF; pfam03461 218496003002 TRCF domain Score = 65.4 E-value = 8.7e-17 218496003003 Helicase conserved C-terminal domain Score = 52.3 E-value = 7.3e-13 218496003004 DEAD/DEAH box helicase Score = 123.9 E-value = 2.1e-34 218496003005 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003006 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.971) with cleavage site probability 0.526 between residues 35 and 36; signal peptide 218496003007 MatE; Region: MatE; pfam01554 218496003008 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 218496003009 12 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 12-34, 49-71, 92-114, 129-151, 158-180, 184-206, 284-306, 321-343, 364-386, 396-418, 430-452 and 457-476 218496003010 Uncharacterized membrane protein family UPF0013 Score = 39.7 E-value = 4.7e-09 218496003011 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 28-47, 57-79, 109-131, 141-163, 176-198 and 223-245 218496003012 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 218496003013 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 218496003014 Walker A/P-loop; other site 218496003015 ATP binding site [chemical binding]; other site 218496003016 Q-loop/lid; other site 218496003017 ABC transporter signature motif; other site 218496003018 Walker B; other site 218496003019 D-loop; other site 218496003020 H-loop/switch region; other site 218496003021 ABC transporter Score = 157.0 E-value = 2.2e-44 218496003022 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003023 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.895 between residues 23 and 24; signal peptide 218496003024 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 218496003025 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 218496003026 Walker A/P-loop; other site 218496003027 ATP binding site [chemical binding]; other site 218496003028 Q-loop/lid; other site 218496003029 ABC transporter signature motif; other site 218496003030 Walker B; other site 218496003031 D-loop; other site 218496003032 H-loop/switch region; other site 218496003033 ABC transporter Score = 144.0 E-value = 1.9e-40 218496003034 PS00211 ABC transporters family signature. 218496003035 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003036 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.703 between residues 42 and 43; signal peptide 218496003037 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 13-35 218496003038 Predicted permease Score = 23.8 E-value = 0.00014 218496003039 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 246-268, 288-322 and 337-359 218496003040 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.970) with cleavage site probability 0.956 between residues 40 and 41; signal peptide 218496003041 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 21-43, 91-108 and 129-151 218496003042 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 218496003043 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 218496003044 active site 218496003045 HIGH motif; other site 218496003046 dimer interface [polypeptide binding]; other site 218496003047 KMSKS motif; other site 218496003048 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 218496003049 S4 domain Score = 20.1 E-value = 0.003 218496003050 tRNA synthetases class I (W and Y) Score = 318.2 E-value = 6.8e-93 218496003051 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218496003052 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 218496003053 putative tRNA-binding site [nucleotide binding]; other site 218496003054 B3/4 domain; Region: B3_4; cl11458 218496003055 tRNA synthetase B5 domain; Region: B5; cl08394 218496003056 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 218496003057 dimer interface [polypeptide binding]; other site 218496003058 motif 3; other site 218496003059 motif 2; other site 218496003060 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 218496003061 Ferredoxin-fold anticodon binding domain Score = 80.6 E-value = 2.3e-21 218496003062 tRNA synthetase B5 domain Score = 46.7 E-value = 3.7e-11 218496003063 B3/4 domain Score = 133.1 E-value = 3.7e-37 218496003064 Putative tRNA binding domain Score = -4.7 E-value = 0.0016 218496003065 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 218496003066 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 218496003067 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 218496003068 dimer interface [polypeptide binding]; other site 218496003069 motif 1; other site 218496003070 active site 218496003071 motif 2; other site 218496003072 motif 3; other site 218496003073 tRNA synthetases class II core domain (F) Score = 307.7 E-value = 9.7e-90 218496003074 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218496003075 Aminoacyl tRNA synthetase class II, N-terminal domain Score = 33.7 E-value = 2.9e-07 218496003076 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 218496003077 23S rRNA binding site [nucleotide binding]; other site 218496003078 L21 binding site [polypeptide binding]; other site 218496003079 L13 binding site [polypeptide binding]; other site 218496003080 Ribosomal protein L20 Score = 159.2 E-value = 5e-45 218496003081 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 218496003082 Ribosomal protein L35 Score = 47.1 E-value = 2.8e-11 218496003083 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 218496003084 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 218496003085 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 218496003086 Translation initiation factor IF-3 Score = 262.4 E-value = 4.2e-76 218496003087 PS00938 Initiation factor 3 signature. 218496003088 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 218496003089 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 218496003090 THF binding site; other site 218496003091 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine...; Region: URO-D_CIMS_like; cl00464 218496003092 Methionine synthase, vitamin-B12 independent Score = 26.1 E-value = 1.1e-14 218496003093 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 4-26, 33-55, 70-89 and 94-116 218496003094 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 218496003095 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218496003096 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 218496003097 Glycosyl transferases group 1 Score = 26.8 E-value = 2.4e-07 218496003098 Ribosome-binding factor A; Region: RBFA; cl00542 218496003099 Ribosome-binding factor A Score = 86.1 E-value = 4.9e-23 218496003100 translation initiation factor IF-2; Validated; Region: infB; PRK05306 218496003101 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 218496003102 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 218496003103 G1 box; other site 218496003104 putative GEF interaction site [polypeptide binding]; other site 218496003105 GTP/Mg2+ binding site [chemical binding]; other site 218496003106 Switch I region; other site 218496003107 G2 box; other site 218496003108 G3 box; other site 218496003109 Switch II region; other site 218496003110 G4 box; other site 218496003111 G5 box; other site 218496003112 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 218496003113 Translation-initiation factor 2; Region: IF-2; pfam11987 218496003114 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 218496003115 Elongation factor Tu domain 2 Score = 31.3 E-value = 1.5e-06 218496003116 Elongation factor Tu domain 2 Score = 56.0 E-value = 5.9e-14 218496003117 Elongation factor Tu GTP binding domain Score = 170.3 E-value = 2.3e-48 218496003118 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003119 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 218496003120 NusA N-terminal domain; Region: NusA_N; pfam08529 218496003121 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 218496003122 RNA binding site [nucleotide binding]; other site 218496003123 homodimer interface [polypeptide binding]; other site 218496003124 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 218496003125 G-X-X-G motif; other site 218496003126 KH domain Score = 10.5 E-value = 0.017 218496003127 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.949) with cleavage site probability 0.289 between residues 32 and 33; signal peptide 218496003128 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 218496003129 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 13-35, 45-64, 71-93, 103-125, 145-167 and 187-209 218496003130 Uncharacterized ACR, YhhQ family COG1738 Score = 23.1 E-value = 4.6e-07 218496003131 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 218496003132 dimer interface [polypeptide binding]; other site 218496003133 substrate binding site [chemical binding]; other site 218496003134 metal binding sites [ion binding]; metal-binding site 218496003135 Inorganic pyrophosphatase Score = 199.5 E-value = 3.6e-57 218496003136 PS00387 Inorganic pyrophosphatase signature. 218496003137 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.991 between residues 23 and 24; signal peptide 218496003138 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 152-171 218496003139 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 218496003140 Queuine tRNA-ribosyltransferase Score = 310.1 E-value = 1.9e-90 218496003141 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.836 between residues 56 and 57; signal peptide 218496003142 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 284-306 218496003143 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.977 between residues 29 and 30; signal peptide 218496003144 NlpC/P60 family; Region: NLPC_P60; cl11438 218496003145 NLP/P60 family Score = 61.8 E-value = 1.1e-15 218496003146 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.994) with cleavage site probability 0.494 between residues 49 and 50; signal peptide 218496003147 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 181-203 218496003148 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.972) with cleavage site probability 0.962 between residues 51 and 52; signal peptide 218496003149 WisP family N-Terminal Region; Region: WND; pfam07861 218496003150 Putative Ig domain; Region: He_PIG; cl09256 218496003151 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 601-623 and 683-705 218496003152 IPP transferase; Region: IPPT; cl00403 218496003153 IPP transferase Score = 212.4 E-value = 4.7e-61 218496003154 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 218496003155 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 218496003156 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 218496003157 FeS/SAM binding site; other site 218496003158 TRAM domain; Region: TRAM; cl01282 218496003159 TRAM domain Score = 15.7 E-value = 0.011 218496003160 Radical SAM superfamily Score = 113.4 E-value = 3.1e-31 218496003161 PS01278 Uncharacterized protein family UPF0004 signature. 218496003162 Uncharacterized protein family UPF0004 Score = 157.0 E-value = 2.2e-44 218496003163 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 218496003164 recombinase A; Provisional; Region: recA; PRK09354 218496003165 hexamer interface [polypeptide binding]; other site 218496003166 Walker A motif; other site 218496003167 ATP binding site [chemical binding]; other site 218496003168 Walker B motif; other site 218496003169 recA bacterial DNA recombination protein Score = 765.1 E-value = 2.1e-227 218496003170 PS00321 recA signature. 218496003171 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003172 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 218496003173 CDP-alcohol phosphatidyltransferase Score = 120.6 E-value = 2.1e-33 218496003174 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 26-48, 68-90, 116-138 and 172-194 218496003175 PS00379 CDP-alcohol phosphatidyltransferases signature. 218496003176 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 218496003177 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 218496003178 FtsK/SpoIIIE family Score = 255.9 E-value = 3.8e-74 218496003179 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003180 5 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 39-57, 72-94, 107-126, 136-158 and 165-187 218496003181 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 218496003182 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 218496003183 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 218496003184 Uncharacterized protein family UPF0036 Score = 261.2 E-value = 9.6e-76 218496003185 Metallo-beta-lactamase superfamily Score = 108.9 E-value = 7.1e-30 218496003186 Thymidylate synthase complementing protein; Region: Thy1; cl03630 218496003187 Thymidylate synthase complementing protein Score = 216.3 E-value = 3.3e-62 218496003188 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 74-96 and 411-433 218496003189 Transcription factor WhiB Score = 114.2 E-value = 1.8e-31 218496003190 Transcription factor WhiB; Region: Whib; pfam02467 218496003191 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 218496003192 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 7-29, 44-66, 79-101, 140-162, 175-197 and 201-223 218496003193 DedA family Score = 85.3 E-value = 8.9e-23 218496003194 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 218496003195 active site 218496003196 dimerization interface [polypeptide binding]; other site 218496003197 Ham1 family Score = 191.1 E-value = 1.3e-54 218496003198 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.740) with cleavage site probability 0.381 between residues 26 and 27; signal peptide 218496003199 ribonuclease PH; Reviewed; Region: rph; PRK00173 218496003200 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 218496003201 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 218496003202 3' exoribonuclease family, domain 2 Score = 71.3 E-value = 1.4e-18 218496003203 3' exoribonuclease family, domain 1 Score = 164.3 E-value = 1.5e-46 218496003204 PS01277 Ribonuclease PH signature. 218496003205 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 218496003206 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 218496003207 active site 218496003208 Nicotinate phosphoribosyltransferase (NAPRTase) Score = -267.1 E-value = 0.0023 218496003209 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.994 between residues 60 and 61; signal peptide 218496003210 WisP family N-Terminal Region; Region: WND; pfam07861 218496003211 Putative Ig domain; Region: He_PIG; cl09256 218496003212 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 694-716 218496003213 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 218496003214 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 218496003215 protein binding site [polypeptide binding]; other site 218496003216 PDZ domain (Also known as DHR or GLGF) Score = 64.8 E-value = 1.3e-16 218496003217 Trypsin Score = 41.7 E-value = 1.2e-09 218496003218 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 58-80 218496003219 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.773 between residues 38 and 39; signal peptide 218496003220 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 218496003221 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 218496003222 Uncharacterised protein family (UPF0182) Score = 776.6 E-value = 7e-231 218496003223 7 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 12-34, 54-76, 108-127, 165-187, 207-224, 250-272 and 279-301 218496003224 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.572 between residues 37 and 38; signal peptide 218496003225 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 218496003226 protein binding site [polypeptide binding]; other site 218496003227 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 218496003228 PDZ domain (Also known as DHR or GLGF) Score = 11.1 E-value = 0.0059 218496003229 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 13-35 218496003230 mycothione reductase; Reviewed; Region: PRK07846 218496003231 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 218496003232 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218496003233 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Score = 34.0 E-value = 1.6e-07 218496003234 Pyridine nucleotide-disulphide oxidoreductase Score = 166.6 E-value = 2.9e-47 218496003235 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 218496003236 pyruvate carboxylase; Reviewed; Region: PRK12999 218496003237 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218496003238 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 218496003239 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 218496003240 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 218496003241 active site 218496003242 catalytic residues [active] 218496003243 metal binding site [ion binding]; metal-binding site 218496003244 homodimer binding site [polypeptide binding]; other site 218496003245 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 218496003246 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 218496003247 carboxyltransferase (CT) interaction site; other site 218496003248 biotinylation site [posttranslational modification]; other site 218496003249 Biotin-requiring enzyme Score = 60.3 E-value = 2.9e-15 218496003250 PS00188 Biotin-requiring enzymes attachment site. 218496003251 Conserved carboxylase domain Score = 188.3 E-value = 8.8e-54 218496003252 HMGL-like Score = 98.5 E-value = 9.5e-27 218496003253 PS00141 Eukaryotic and viral aspartyl proteases active site. 218496003254 Biotin carboxylase C-terminal domain Score = 185.0 E-value = 8.4e-53 218496003255 Carbamoyl-phosphate synthase L chain, ATP binding domain Score = 332.6 E-value = 3.3e-97 218496003256 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 218496003257 D-ala D-ala ligase Score = 25.2 E-value = 4.5e-07 218496003258 Carbamoyl-phosphate synthase L chain, N-terminal domain Score = 131.7 E-value = 9.2e-37 218496003259 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 218496003260 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 218496003261 P loop; other site 218496003262 Nucleotide binding site [chemical binding]; other site 218496003263 DTAP/Switch II; other site 218496003264 Switch I; other site 218496003265 ParA family ATPase Score = 59.5 E-value = 5.2e-15 218496003266 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 69-91, 111-133, 179-201 and 206-228 218496003267 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 218496003268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 218496003269 Histidine kinase; Region: HisKA_2; cl06527 218496003270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 218496003271 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Score = 63.1 E-value = 4.2e-16 218496003272 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 218496003273 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 218496003274 inhibitor-cofactor binding pocket; inhibition site 218496003275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218496003276 catalytic residue [active] 218496003277 Aminotransferase class-III Score = 473.8 E-value = 9.6e-140 218496003278 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 218496003279 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 218496003280 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 218496003281 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 218496003282 homodimer interface [polypeptide binding]; other site 218496003283 NADP binding site [chemical binding]; other site 218496003284 substrate binding site [chemical binding]; other site 218496003285 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Score = 216.8 E-value = 2.3e-62 218496003286 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Score = 148.0 E-value = 1.2e-41 218496003287 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 218496003288 dimer interface [polypeptide binding]; other site 218496003289 glycine-pyridoxal phosphate binding site [chemical binding]; other site 218496003290 active site 218496003291 folate binding site [chemical binding]; other site 218496003292 Serine hydroxymethyltransferase Score = 674.6 E-value = 3.5e-200 218496003293 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 218496003294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 218496003295 S-adenosylmethionine binding site [chemical binding]; other site 218496003296 Conserved hypothetical protein 95 Score = 165.7 E-value = 5.3e-47 218496003297 PS00092 N-6 Adenine-specific DNA methylases signature. 218496003298 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 218496003299 lipoyl attachment site [posttranslational modification]; other site 218496003300 Glycine cleavage H-protein Score = 122.7 E-value = 4.9e-34 218496003301 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 218496003302 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 218496003303 Glycine cleavage T-protein (aminomethyl transferase) Score = 272.4 E-value = 4.1e-79 218496003304 GTP-binding protein YchF; Reviewed; Region: PRK09601 218496003305 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 218496003306 G1 box; other site 218496003307 GTP/Mg2+ binding site [chemical binding]; other site 218496003308 Switch I region; other site 218496003309 G2 box; other site 218496003310 Switch II region; other site 218496003311 G3 box; other site 218496003312 G4 box; other site 218496003313 G5 box; other site 218496003314 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 218496003315 GTP1/OBG family Score = 14.6 E-value = 0.00039 218496003316 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003317 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.951) with cleavage site probability 0.813 between residues 24 and 25; signal peptide 218496003318 RmuC family; Region: RmuC; pfam02646 218496003319 Uncharacterized BCR, YigN family, COG1322 Score = 129.6 E-value = 3.9e-36 218496003320 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 46-65, 101-120 and 130-152 218496003321 LytB protein; Region: LYTB; cl00507 218496003322 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 218496003323 LytB protein Score = 512.1 E-value = 2.9e-151 218496003324 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 218496003325 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 218496003326 generic binding surface II; other site 218496003327 generic binding surface I; other site 218496003328 Exonuclease VII, large subunit Score = 103.9 E-value = 2.2e-28 218496003329 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 218496003330 Exonuclease VII small subunit Score = 46.2 E-value = 5.2e-11 218496003331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218496003332 D-galactonate transporter; Region: 2A0114; TIGR00893 218496003333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218496003334 Sugar (and other) transporter Score = -104.7 E-value = 0.0004 218496003335 11 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 20-42, 49-68, 73-95, 107-129, 139-158, 207-229, 244-266, 279-301, 306-328, 344-366 and 371-393 218496003336 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 218496003337 substrate binding site [chemical binding]; other site 218496003338 ATP binding site [chemical binding]; other site 218496003339 pfkB family carbohydrate kinase Score = 116.3 E-value = 4e-32 218496003340 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 218496003341 intersubunit interface [polypeptide binding]; other site 218496003342 active site 218496003343 Zn2+ binding site [ion binding]; other site 218496003344 Class II Aldolase and Adducin N-terminal domain Score = 244.3 E-value = 1.2e-70 218496003345 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 218496003346 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 218496003347 AP (apurinic/apyrimidinic) site pocket; other site 218496003348 DNA interaction; other site 218496003349 Metal-binding active site; metal-binding site 218496003350 Putative hexulose-6-phosphate isomerase Score = 186.8 E-value = 2.5e-53 218496003351 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 218496003352 active site 218496003353 dimer interface [polypeptide binding]; other site 218496003354 magnesium binding site [ion binding]; other site 218496003355 Orotidine 5'-phosphate decarboxylase / HUMPS family Score = 50.7 E-value = 2.2e-12 218496003356 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 218496003357 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active...; Region: PTE; cd00530 218496003358 active site 218496003359 substrate binding pocket [chemical binding]; other site 218496003360 homodimer interaction site [polypeptide binding]; other site 218496003361 Phosphotriesterase family Score = 113.1 E-value = 3.8e-31 218496003362 PS01323 Phosphotriesterase family signature 2. 218496003363 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 218496003364 putative active site [active] 218496003365 catalytic residue [active] 218496003366 Peptidyl-tRNA hydrolase Score = 206.5 E-value = 2.9e-59 218496003367 PS01195 Peptidyl-tRNA hydrolase signature 1. 218496003368 5 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 15-30, 51-73, 93-115, 161-178 and 188-210 218496003369 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.706) with cleavage site probability 0.606 between residues 45 and 46; signal peptide 218496003370 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 7-29, 44-66 and 87-109 218496003371 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 218496003372 5S rRNA interface [nucleotide binding]; other site 218496003373 CTC domain interface; other site 218496003374 L16 interface [polypeptide binding]; other site 218496003375 Ribosomal L25p family Score = 61.3 E-value = 1.4e-15 218496003376 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218496003377 catalytic core [active] 218496003378 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218496003379 Phosphoglycerate mutase family Score = 343.9 E-value = 1.2e-100 218496003380 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 218496003381 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 218496003382 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 218496003383 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 28-50 218496003384 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.766) with cleavage site probability 0.530 between residues 38 and 39; signal peptide 218496003385 Vitamin K epoxide reductase family; Region: VKOR; cl01729 218496003386 5 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 9-31, 69-91, 98-120, 124-146 and 158-180 218496003387 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 218496003388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 218496003389 Acetyltransferase (GNAT) family Score = 56.8 E-value = 3.4e-14 218496003390 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 218496003391 active site 218496003392 Ap6A binding site [chemical binding]; other site 218496003393 nudix motif; other site 218496003394 metal binding site [ion binding]; metal-binding site 218496003395 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218496003396 catalytic core [active] 218496003397 NUDIX domain Score = 53.0 E-value = 4.7e-13 218496003398 PS00893 mutT domain signature. 218496003399 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003400 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 218496003401 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.817) with cleavage site probability 0.457 between residues 33 and 34; signal peptide 218496003402 Large-conductance mechanosensitive channel, MscL Score = 26.7 E-value = 2.8e-09 218496003403 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 13-35 and 73-95 218496003404 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 218496003405 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 218496003406 metal binding site [ion binding]; metal-binding site 218496003407 Periplasmic solute binding protein family Score = 252.2 E-value = 5.1e-73 218496003408 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218496003409 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 218496003410 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 218496003411 ABC transporter Score = 167.0 E-value = 2.2e-47 218496003412 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003413 PS00211 ABC transporters family signature. 218496003414 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 218496003415 ABC-ATPase subunit interface; other site 218496003416 dimer interface [polypeptide binding]; other site 218496003417 putative PBP binding regions; other site 218496003418 ABC 3 transport family Score = 310.6 E-value = 1.4e-90 218496003419 8 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 21-43, 58-80, 93-115, 130-149, 170-192, 196-215, 222-241 and 251-273 218496003420 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.804 between residues 35 and 36; signal peptide 218496003421 WisP family N-Terminal Region; Region: WND; pfam07861 218496003422 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.673) with cleavage site probability 0.605 between residues 37 and 38; signal peptide 218496003423 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 4-26, 93-115 and 120-142 218496003424 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 218496003425 5-formyltetrahydrofolate cyclo-ligase family Score = 93.8 E-value = 2.4e-25 218496003426 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 218496003427 11 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 76-98, 132-154, 174-193, 200-222, 242-264, 305-327, 364-386, 399-421, 426-448, 455-474 and 479-501 218496003428 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.843) with cleavage site probability 0.320 between residues 39 and 40; signal peptide 218496003429 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 16-33, 43-65, 85-107 and 117-139 218496003430 elongation factor G; Reviewed; Region: PRK00007 218496003431 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 218496003432 G1 box; other site 218496003433 putative GEF interaction site [polypeptide binding]; other site 218496003434 GTP/Mg2+ binding site [chemical binding]; other site 218496003435 Switch I region; other site 218496003436 G2 box; other site 218496003437 G3 box; other site 218496003438 Switch II region; other site 218496003439 G4 box; other site 218496003440 G5 box; other site 218496003441 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 218496003442 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 218496003443 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 218496003444 Elongation factor G C-terminus Score = 162.7 E-value = 4.5e-46 218496003445 Elongation factor G, domain IV Score = 236.2 E-value = 3.3e-68 218496003446 Elongation factor Tu domain 2 Score = 68.0 E-value = 1.4e-17 218496003447 Elongation factor Tu GTP binding domain Score = 376.6 E-value = 1.8e-110 218496003448 PS00301 GTP-binding elongation factors signature. 218496003449 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003450 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 218496003451 Ribosomal protein S7p/S5e Score = 276.1 E-value = 3.2e-80 218496003452 PS00052 Ribosomal protein S7 signature. 218496003453 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 218496003454 S17 interaction site [polypeptide binding]; other site 218496003455 S8 interaction site; other site 218496003456 16S rRNA interaction site [nucleotide binding]; other site 218496003457 streptomycin interaction site [chemical binding]; other site 218496003458 23S rRNA interaction site [nucleotide binding]; other site 218496003459 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 218496003460 Ribosomal protein S12 Score = 187.0 E-value = 2.1e-53 218496003461 PS00055 Ribosomal protein S12 signature. 218496003462 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.510 between residues 43 and 44; signal peptide 218496003463 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 15-37 218496003464 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 218496003465 domain; Region: GreA_GreB_N; pfam03449 218496003466 C-term; Region: GreA_GreB; pfam01272 218496003467 Prokaryotic transcription elongation factor, GreA/GreB, N-terminal domain Score = 90.4 E-value = 2.6e-24 218496003468 threonine dehydratase; Provisional; Region: PRK08198 218496003469 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 218496003470 tetramer interface [polypeptide binding]; other site 218496003471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218496003472 catalytic residue [active] 218496003473 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 218496003474 ACT domain Score = 25.7 E-value = 7.5e-05 218496003475 Pyridoxal-phosphate dependent enzyme Score = 231.9 E-value = 6.7e-67 218496003476 PS00061 Short-chain dehydrogenases/reductases family signature. 218496003477 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 218496003478 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 218496003479 dimer interface [polypeptide binding]; other site 218496003480 putative radical transfer pathway; other site 218496003481 diiron center [ion binding]; other site 218496003482 tyrosyl radical; other site 218496003483 Ribonucleotide reductase, small chain Score = 130.3 E-value = 2.5e-36 218496003484 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 166-188 218496003485 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06539 218496003486 ATP cone domain; Region: ATP-cone; pfam03477 218496003487 Class I ribonucleotide reductase; Region: RNR_I; cd01679 218496003488 active site 218496003489 dimer interface [polypeptide binding]; other site 218496003490 catalytic residues [active] 218496003491 effector binding site; other site 218496003492 R2 peptide binding site; other site 218496003493 Ribonucleotide reductase, barrel domain Score = 432.1 E-value = 3.6e-127 218496003494 PS00089 Ribonucleotide reductase large subunit signature. 218496003495 Ribonucleotide reductase, all-alpha domain Score = 37.0 E-value = 3.1e-08 218496003496 ATP cone domain Score = 25.5 E-value = 8.9e-05 218496003497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218496003498 putative substrate translocation pore; other site 218496003499 12 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 21-43, 49-71, 78-100, 105-127, 140-162, 172-194, 214-236, 251-273, 280-299, 304-326, 339-361 and 366-388 218496003500 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 218496003501 putative active site [active] 218496003502 putative DNA binding site [nucleotide binding]; other site 218496003503 putative phosphate binding site [ion binding]; other site 218496003504 putative catalytic site [active] 218496003505 metal binding site A [ion binding]; metal-binding site 218496003506 putative AP binding site [nucleotide binding]; other site 218496003507 putative metal binding site B [ion binding]; other site 218496003508 Endonuclease/Exonuclease/phosphatase family Score = 131.0 E-value = 1.5e-36 218496003509 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 218496003510 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 218496003511 active site 218496003512 HIGH motif; other site 218496003513 dimer interface [polypeptide binding]; other site 218496003514 KMSKS motif; other site 218496003515 tRNA synthetases class I (W and Y) Score = 268.1 E-value = 8.5e-78 218496003516 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218496003517 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 218496003518 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 218496003519 catalytic motif [active] 218496003520 Zn binding site [ion binding]; other site 218496003521 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 218496003522 Cytidine and deoxycytidylate deaminase zinc-binding region Score = 64.0 E-value = 2.3e-16 218496003523 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 218496003524 RibD C-terminal domain Score = 112.1 E-value = 7.7e-31 218496003525 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 218496003526 Lumazine binding domain; Region: Lum_binding; pfam00677 218496003527 Lumazine binding domain; Region: Lum_binding; pfam00677 218496003528 Lumazine binding domain Score = 51.3 E-value = 1.5e-12 218496003529 Lumazine binding domain Score = 79.9 E-value = 3.8e-21 218496003530 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 218496003531 3,4-dihydroxy-2-butanone 4-phosphate synthase Score = 289.6 E-value = 2.8e-84 218496003532 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 218496003533 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 218496003534 dimerization interface [polypeptide binding]; other site 218496003535 active site 218496003536 GTP cyclohydrolase II Score = 272.7 E-value = 3.4e-79 218496003537 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 218496003538 homopentamer interface [polypeptide binding]; other site 218496003539 active site 218496003540 6,7-dimethyl-8-ribityllumazine synthase Score = 97.0 E-value = 2.6e-26 218496003541 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 218496003542 Isochorismatase family; Region: Isochorismatase; pfam00857 218496003543 catalytic triad [active] 218496003544 Isochorismatase family Score = -6.0 E-value = 4.3e-05 218496003545 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.459 between residues 32 and 33; signal peptide 218496003546 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 218496003547 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 218496003548 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218496003549 DNA polymerase III subunit delta'; Validated; Region: PRK07940 218496003550 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 218496003551 thymidylate kinase; Validated; Region: tmk; PRK00698 218496003552 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 218496003553 TMP-binding site; other site 218496003554 ATP-binding site [chemical binding]; other site 218496003555 Thymidylate kinase Score = 147.2 E-value = 2e-41 218496003556 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003557 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 218496003558 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 218496003559 active site 218496003560 interdomain interaction site; other site 218496003561 putative metal-binding site [ion binding]; other site 218496003562 nucleotide binding site [chemical binding]; other site 218496003563 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 218496003564 domain I; other site 218496003565 DNA binding groove [nucleotide binding] 218496003566 phosphate binding site [ion binding]; other site 218496003567 domain II; other site 218496003568 domain III; other site 218496003569 nucleotide binding site [chemical binding]; other site 218496003570 catalytic site [active] 218496003571 domain IV; other site 218496003572 DNA topoisomerase Score = 570.7 E-value = 6.7e-169 218496003573 PS00396 Prokaryotic DNA topoisomerase I active site. 218496003574 Toprim domain Score = 115.0 E-value = 1e-31 218496003575 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 218496003576 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 33-55 218496003577 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 218496003578 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 21-43 218496003579 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 25-47 218496003580 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.728) with cleavage site probability 0.656 between residues 35 and 36; signal peptide 218496003581 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 134-151, 155-177 and 280-302 218496003582 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 218496003583 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 218496003584 ATP binding site [chemical binding]; other site 218496003585 Walker A motif; other site 218496003586 hexamer interface [polypeptide binding]; other site 218496003587 Walker B motif; other site 218496003588 Type II/IV secretion system protein Score = -91.3 E-value = 5.9e-05 218496003589 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003590 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 218496003591 homotrimer interaction site [polypeptide binding]; other site 218496003592 putative active site [active] 218496003593 Endoribonuclease L-PSP Score = 76.4 E-value = 4.1e-20 218496003594 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.673 between residues 28 and 29; signal peptide 218496003595 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 218496003596 Transglycosylase; Region: Transgly; cl07896 218496003597 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 218496003598 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 218496003599 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 218496003600 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 7-29 218496003601 Transglycosylase Score = 145.9 E-value = 5.2e-41 218496003602 Penicillin binding protein transpeptidase domain Score = -38.2 E-value = 7.9e-08 218496003603 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003604 PASTA domain Score = 41.7 E-value = 1.1e-09 218496003605 PASTA domain Score = 46.9 E-value = 3.1e-11 218496003606 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 218496003607 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 218496003608 active site 218496003609 metal binding site [ion binding]; metal-binding site 218496003610 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 7-25 218496003611 Calcineurin-like phosphoesterase Score = 38.5 E-value = 1.1e-08 218496003612 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 218496003613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218496003614 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 218496003615 Semialdehyde dehydrogenase, dimerisation domain Score = 198.6 E-value = 7.1e-57 218496003616 PS01103 Aspartate-semialdehyde dehydrogenase signature. 218496003617 Semialdehyde dehydrogenase, NAD binding domain Score = 133.9 E-value = 2.1e-37 218496003618 aspartate kinase; Reviewed; Region: PRK06635 218496003619 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 218496003620 putative nucleotide binding site [chemical binding]; other site 218496003621 putative catalytic residues [active] 218496003622 putative Mg ion binding site [ion binding]; other site 218496003623 putative aspartate binding site [chemical binding]; other site 218496003624 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 218496003625 putative allosteric regulatory site; other site 218496003626 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 218496003627 putative allosteric regulatory residue; other site 218496003628 ACT domain Score = 27.6 E-value = 2e-05 218496003629 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 218496003630 ACT domain Score = 22.3 E-value = 0.0008 218496003631 Amino acid kinase family Score = 253.1 E-value = 2.6e-73 218496003632 PS00324 Aspartokinase signature. 218496003633 recombination protein RecR; Reviewed; Region: recR; PRK00076 218496003634 RecR protein; Region: RecR; pfam02132 218496003635 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 218496003636 putative active site [active] 218496003637 putative metal-binding site [ion binding]; other site 218496003638 tetramer interface [polypeptide binding]; other site 218496003639 Toprim domain Score = 57.2 E-value = 2.6e-14 218496003640 RecR protein Score = 54.8 E-value = 1.3e-13 218496003641 PS01300 RecR protein signature. 218496003642 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 218496003643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 218496003644 Walker A motif; other site 218496003645 ATP binding site [chemical binding]; other site 218496003646 Walker B motif; other site 218496003647 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 218496003648 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003649 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 218496003650 core dimer interface [polypeptide binding]; other site 218496003651 peripheral dimer interface [polypeptide binding]; other site 218496003652 L10 interface [polypeptide binding]; other site 218496003653 L11 interface [polypeptide binding]; other site 218496003654 putative EF-Tu interaction site [polypeptide binding]; other site 218496003655 putative EF-G interaction site [polypeptide binding]; other site 218496003656 Ribosomal protein L7/L12 C-terminal domain Score = 118.1 E-value = 1.2e-32 218496003657 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 218496003658 23S rRNA interface [nucleotide binding]; other site 218496003659 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 218496003660 Ribosomal protein L10 Score = 99.6 E-value = 4.4e-27 218496003661 PS01109 Ribosomal protein L10 signature. 218496003662 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 218496003663 mRNA/rRNA interface [nucleotide binding]; other site 218496003664 Ribosomal protein L1p/L10e family Score = 298.3 E-value = 6.9e-87 218496003665 PS01199 Ribosomal protein L1 signature. 218496003666 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 218496003667 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 218496003668 23S rRNA interface [nucleotide binding]; other site 218496003669 L7/L12 interface [polypeptide binding]; other site 218496003670 putative thiostrepton binding site; other site 218496003671 L25 interface [polypeptide binding]; other site 218496003672 Ribosomal protein L11, RNA binding domain Score = 102.6 E-value = 5.5e-28 218496003673 Ribosomal protein L11, N-terminal domain Score = 134.9 E-value = 1e-37 218496003674 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 218496003675 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 218496003676 putative homodimer interface [polypeptide binding]; other site 218496003677 KOW motif Score = 36.8 E-value = 3.6e-08 218496003678 Transcription termination factor nusG Score = 53.4 E-value = 3.6e-13 218496003679 aspartate aminotransferase; Provisional; Region: PRK08361 218496003680 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218496003681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218496003682 homodimer interface [polypeptide binding]; other site 218496003683 catalytic residue [active] 218496003684 Aminotransferase class I and II Score = 187.7 E-value = 1.3e-53 218496003685 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 218496003686 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 218496003687 FAD binding domain; Region: FAD_binding_4; pfam01565 218496003688 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 218496003689 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain Score = 83.6 E-value = 2.9e-22 218496003690 FAD binding domain Score = 15.9 E-value = 2e-05 218496003691 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 218496003692 active site 218496003693 catalytic site [active] 218496003694 MaoC like domain Score = 68.3 E-value = 1.1e-17 218496003695 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 218496003696 active site 218496003697 catalytic site [active] 218496003698 amidophosphoribosyltransferase; Provisional; Region: PRK09246 218496003699 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 218496003700 active site 218496003701 tetramer interface [polypeptide binding]; other site 218496003702 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 218496003703 Phosphoribosyl transferase domain Score = 20.4 E-value = 2.4e-05 218496003704 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 218496003705 Glutamine amidotransferases class-II Score = 245.1 E-value = 6.8e-71 218496003706 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 218496003707 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 218496003708 dimerization interface [polypeptide binding]; other site 218496003709 putative ATP binding site [chemical binding]; other site 218496003710 AIR synthase related protein, C-terminal domain Score = 90.1 E-value = 3.1e-24 218496003711 AIR synthase related protein, N-terminal domain Score = 179.9 E-value = 2.9e-51 218496003712 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 218496003713 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 218496003714 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 218496003715 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 218496003716 Phosphoribosylglycinamide synthetase, N domain Score = 104.5 E-value = 1.5e-28 218496003717 Phosphoribosylglycinamide synthetase, B domain Score = 51.9 E-value = 9.8e-13 218496003718 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Score = 218.0 E-value = 1e-62 218496003719 PS00184 Phosphoribosylglycinamide synthetase signature. 218496003720 Phosphoribosylglycinamide synthetase, C domain Score = 73.6 E-value = 2.9e-19 218496003721 seryl-tRNA synthetase; Provisional; Region: PRK05431 218496003722 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 218496003723 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 218496003724 dimer interface [polypeptide binding]; other site 218496003725 active site 218496003726 motif 1; other site 218496003727 motif 2; other site 218496003728 motif 3; other site 218496003729 tRNA synthetase class II core domain (G, H, P, S and T) Score = 155.5 E-value = 6.5e-44 218496003730 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218496003731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 218496003732 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 218496003733 active site 218496003734 motif I; other site 218496003735 motif II; other site 218496003736 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.373 between residues 30 and 31; signal peptide 218496003737 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 218496003738 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 12-34 218496003739 Cell envelope-related transcriptional attenuator domain Score = 167.1 E-value = 2.1e-47 218496003740 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 218496003741 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 218496003742 inhibitor-cofactor binding pocket; inhibition site 218496003743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218496003744 catalytic residue [active] 218496003745 Aminotransferase class-III Score = 317.9 E-value = 8.1e-93 218496003746 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 218496003747 dimer interface [polypeptide binding]; other site 218496003748 active site 218496003749 Schiff base residues; other site 218496003750 Delta-aminolevulinic acid dehydratase Score = 489.8 E-value = 1.6e-144 218496003751 PS00169 Delta-aminolevulinic acid dehydratase active site. 218496003752 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 218496003753 active site 218496003754 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 218496003755 Uroporphyrinogen-III synthase HemD Score = 34.1 E-value = 2.8e-08 218496003756 porphobilinogen deaminase; Region: hemC; TIGR00212 218496003757 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 218496003758 domain interfaces; other site 218496003759 active site 218496003760 Porphobilinogen deaminase, C-terminal domain Score = 16.3 E-value = 2.7e-05 218496003761 Porphobilinogen deaminase, dipyromethane cofactor binding domain Score = 184.4 E-value = 1.3e-52 218496003762 ferrochelatase; Reviewed; Region: hemH; PRK00035 218496003763 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 218496003764 C-terminal domain interface [polypeptide binding]; other site 218496003765 active site 218496003766 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 218496003767 active site 218496003768 N-terminal domain interface [polypeptide binding]; other site 218496003769 Ferrochelatase Score = 279.4 E-value = 3.2e-81 218496003770 Chlorite dismutase; Region: Chlor_dismutase; cl01280 218496003771 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 218496003772 substrate binding site [chemical binding]; other site 218496003773 active site 218496003774 Uroporphyrinogen decarboxylase (URO-D) Score = 388.0 E-value = 6.5e-114 218496003775 PS00907 Uroporphyrinogen decarboxylase signature 2. 218496003776 PS00906 Uroporphyrinogen decarboxylase signature 1. 218496003777 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 218496003778 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218496003779 NAD(P) binding pocket [chemical binding]; other site 218496003780 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 218496003781 Glutamyl-tRNAGlu reductase Score = 63.3 E-value = 3e-17 218496003782 O-succinylbenzoate synthase; Provisional; Region: PRK02901 218496003783 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway...; Region: OSBS; cd03320 218496003784 active site 218496003785 replicative DNA helicase; Region: DnaB; TIGR00665 218496003786 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 218496003787 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 218496003788 Walker A motif; other site 218496003789 ATP binding site [chemical binding]; other site 218496003790 Walker B motif; other site 218496003791 DNA binding loops [nucleotide binding] 218496003792 DnaB-like helicase N terminal domain Score = 126.0 E-value = 4.8e-35 218496003793 DnaB-like helicase C terminal domain Score = 368.0 E-value = 6.8e-108 218496003794 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003795 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.734 between residues 24 and 25; signal peptide 218496003796 Copper resistance protein CopC; Region: CopC; cl01012 218496003797 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 7-29 and 169-191 218496003798 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 218496003799 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 218496003800 active site 218496003801 motif I; other site 218496003802 motif II; other site 218496003803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 218496003804 haloacid dehalogenase-like hydrolase Score = 45.9 E-value = 6.5e-11 218496003805 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 218496003806 Phosphoribosyl transferase domain Score = 58.3 E-value = 1.2e-14 218496003807 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 218496003808 putative phosphate binding site [ion binding]; other site 218496003809 putative catalytic site [active] 218496003810 active site 218496003811 metal binding site A [ion binding]; metal-binding site 218496003812 DNA binding site [nucleotide binding] 218496003813 putative AP binding site [nucleotide binding]; other site 218496003814 putative metal binding site B [ion binding]; other site 218496003815 Endonuclease/Exonuclease/phosphatase family Score = 160.2 E-value = 2.5e-45 218496003816 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 101-123, 143-165, 185-207 and 217-239 218496003817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 218496003818 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 218496003819 Walker A motif; other site 218496003820 ATP binding site [chemical binding]; other site 218496003821 Walker B motif; other site 218496003822 arginine finger; other site 218496003823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 218496003824 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 218496003825 Walker A motif; other site 218496003826 ATP binding site [chemical binding]; other site 218496003827 Walker B motif; other site 218496003828 arginine finger; other site 218496003829 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 218496003830 PS00871 Chaperonins clpA/B signature 2. 218496003831 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003832 ATPase family associated with various cellular activities (AAA) Score = 53.5 E-value = 3.2e-13 218496003833 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003834 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 218496003835 DNA binding residues [nucleotide binding] 218496003836 putative dimer interface [polypeptide binding]; other site 218496003837 Bacterial regulatory proteins, merR family Score = 23.4 E-value = 0.00023 218496003838 Predicted helix-turn-helix motif with score 1107.000, SD 2.96 at aa 7-28, sequence FTVTVAAALSGMHPQTLRKLDR 218496003839 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 218496003840 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 218496003841 HSP70 interaction site [polypeptide binding]; other site 218496003842 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 218496003843 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 218496003844 DnaJ C terminal region Score = 115.5 E-value = 6.9e-32 218496003845 DnaJ domain Score = 120.0 E-value = 3.1e-33 218496003846 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 218496003847 dimer interface [polypeptide binding]; other site 218496003848 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 218496003849 GrpE Score = 67.1 E-value = 2.6e-17 218496003850 PS01071 grpE protein signature. 218496003851 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 218496003852 Hsp70 protein Score = 1198.7 E-value = 0 218496003853 PS01036 Heat shock hsp70 proteins family signature 3. 218496003854 PS00329 Heat shock hsp70 proteins family signature 2. 218496003855 PS00297 Heat shock hsp70 proteins family signature 1. 218496003856 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 218496003857 nucleoside/Zn binding site; other site 218496003858 dimer interface [polypeptide binding]; other site 218496003859 catalytic motif [active] 218496003860 Cytidine and deoxycytidylate deaminase zinc-binding region Score = 138.2 E-value = 1.1e-38 218496003861 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 218496003862 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 218496003863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218496003864 Delta 1-pyrroline-5-carboxylate reductase Score = 73.8 E-value = 2.5e-19 218496003865 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 218496003866 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 218496003867 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-...; Region: Asp_Lys_Asn_RS_N; cd04100 218496003868 Dimer interface [polypeptide binding]; other site 218496003869 anticodon binding site; other site 218496003870 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 218496003871 motif 1; other site 218496003872 dimer interface [polypeptide binding]; other site 218496003873 active site 218496003874 motif 2; other site 218496003875 motif 3; other site 218496003876 tRNA synthetases class II (D, K and N) Score = 212.8 E-value = 3.6e-61 218496003877 OB-fold nucleic acid binding domain Score = 39.6 E-value = 4.9e-09 218496003878 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218496003879 catalytic core [active] 218496003880 Phosphoglycerate mutase family Score = -64.0 E-value = 3.5e-06 218496003881 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.764 between residues 50 and 51; signal peptide 218496003882 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 218496003883 catalytic residues [active] 218496003884 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 28-50 218496003885 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218496003886 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.965) with cleavage site probability 0.585 between residues 28 and 29; signal peptide 218496003887 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 218496003888 6 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 15-37, 57-79, 84-106, 119-141, 156-178 and 191-213 218496003889 Cytochrome C biogenesis protein transmembrane region Score = 125.3 E-value = 8e-35 218496003890 PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 218496003891 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 218496003892 ResB-like family; Region: ResB; pfam05140 218496003893 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.679 between residues 26 and 27; signal peptide 218496003894 4 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 5-24, 54-76, 173-195 and 450-472 218496003895 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.740) with cleavage site probability 0.316 between residues 30 and 31; signal peptide 218496003896 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 218496003897 8 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 15-37, 90-112, 117-139, 146-168, 183-205, 232-251, 266-285 and 292-314 218496003898 Cytochrome C assembly protein Score = 64.4 E-value = 1.7e-16 218496003899 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.804 between residues 35 and 36; signal peptide 218496003900 WisP family N-Terminal Region; Region: WND; pfam07861 218496003901 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.725) with cleavage site probability 0.502 between residues 31 and 32; signal peptide 218496003902 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 218496003903 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 15-34, 41-61 and 71-93 218496003904 ABC 3 transport family Score = 65.4 E-value = 2.9e-17 218496003905 WisP family C-Terminal Region; Region: CCD; pfam07860 218496003906 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 218496003907 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 218496003908 active site 218496003909 HIGH motif; other site 218496003910 KMSKS motif; other site 218496003911 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 218496003912 tRNA binding surface [nucleotide binding]; other site 218496003913 anticodon binding site; other site 218496003914 tRNA synthetases class I (I, L, M and V) Score = -142.1 E-value = 1.2e-11 218496003915 Putative Ig domain; Region: He_PIG; cl09256 218496003916 Putative Ig domain; Region: He_PIG; cl09256 218496003917 Putative Ig domain; Region: He_PIG; cl09256 218496003918 Putative Ig domain; Region: He_PIG; cl09256 218496003919 Putative Ig domain; Region: He_PIG; cl09256 218496003920 Putative Ig domain; Region: He_PIG; cl09256 218496003921 Putative Ig domain; Region: He_PIG; cl09256 218496003922 Putative Ig domain; Region: He_PIG; cl09256 218496003923 Putative Ig domain; Region: He_PIG; cl09256 218496003924 WisP family C-Terminal Region; Region: CCD; pfam07860 218496003925 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 218496003926 Ligand binding site [chemical binding]; other site 218496003927 Putative Catalytic site [active] 218496003928 DXD motif; other site 218496003929 Glycosyl transferase Score = 97.1 E-value = 2.4e-26 218496003930 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.970) with cleavage site probability 0.605 between residues 24 and 25; signal peptide 218496003931 2 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 39-61 and 76-98 218496003932 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 4-21 218496003933 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 218496003934 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 218496003935 active site 218496003936 Zn binding site [ion binding]; other site 218496003937 Peptidase family M13 Score = 248.2 E-value = 8.3e-72 218496003938 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218496003939 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 218496003940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 218496003941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 218496003942 motif II; other site 218496003943 haloacid dehalogenase-like hydrolase Score = 64.8 E-value = 1.3e-16 218496003944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 218496003945 PS00092 N-6 Adenine-specific DNA methylases signature. 218496003946 DNA methylase Score = 112.9 E-value = 4.3e-31 218496003947 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 218496003948 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 218496003949 phosphopeptide binding site; other site 218496003950 FHA domain Score = 73.2 E-value = 3.8e-19 218496003951 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 218496003952 phosphopeptide binding site; other site 218496003953 FHA domain Score = 82.2 E-value = 7.7e-22 218496003954 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.753) with cleavage site probability 0.324 between residues 44 and 45; signal peptide 218496003955 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 218496003956 12 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 20-42, 47-69, 76-98, 108-130, 137-156, 171-193, 213-230, 234-253, 258-280, 348-370, 377-399 and 409-431 218496003957 Cell cycle protein Score = 186.8 E-value = 2.4e-53 218496003958 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 218496003959 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 23-45 218496003960 Penicillin binding protein transpeptidase domain Score = 269.1 E-value = 4e-78 218496003961 PS00017 ATP/GTP-binding site motif A (P-loop). 218496003962 Catalytic domain of Protein Kinases; Region: PKc; cd00180 218496003963 active site 218496003964 ATP binding site [chemical binding]; other site 218496003965 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 218496003966 substrate binding site [chemical binding]; other site 218496003967 activation loop (A-loop); other site 218496003968 Protein kinase domain Score = 183.5 E-value = 2.4e-52 218496003969 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 218496003970 PS00108 Serine/Threonine protein kinases active-site signature. 218496003971 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 345-367 218496003972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 218496003973 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 218496003974 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 306-328 218496003975 PASTA domain Score = 45.4 E-value = 9.3e-11 218496003976 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 218496003977 Pyridine nucleotide-disulphide oxidoreductase Score = 104.5 E-value = 1.5e-28 218496003978 Protein of unknown function (DUF501); Region: DUF501; cl00652 218496003979 Protein of unknown function (DUF501) Score = 152.0 E-value = 7.5e-43 218496003980 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.650 between residues 35 and 36; signal peptide 218496003981 Septum formation initiator; Region: DivIC; cl11433 218496003982 1 probable transmembrane helix predicted for Unknown_CDS by TMHMM2.0 at aa 12-34 218496003983 enolase; Provisional; Region: eno; PRK00077 218496003984 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 218496003985 dimer interface [polypeptide binding]; other site 218496003986 metal binding site [ion binding]; metal-binding site 218496003987 substrate binding pocket [chemical binding]; other site 218496003988 Enolase, C-terminal TIM barrel domain Score = 542.5 E-value = 2e-160 218496003989 PS00164 Enolase signature. 218496003990 Enolase, N-terminal domain Score = 215.3 E-value = 6.4e-62 218496003991 histidyl-tRNA synthetase; Region: hisS; TIGR00442 218496003992 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 218496003993 dimer interface [polypeptide binding]; other site 218496003994 motif 1; other site 218496003995 active site 218496003996 motif 2; other site 218496003997 motif 3; other site 218496003998 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218496003999 tRNA synthetase class II core domain (G, H, P, S and T) Score = 71.4 E-value = 1.4e-18 218496004000 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.618 between residues 25 and 26; signal peptide 218496004001 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 218496004002 Sodium/hydrogen exchanger family Score = -105.4 E-value = 0.0041 218496004003 12 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 9-28, 43-65, 86-108, 118-137, 144-166, 170-192, 199-216, 220-235, 248-270, 280-302, 309-331 and 346-368 218496004004 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 218496004005 trimer interface [polypeptide binding]; other site 218496004006 active site 218496004007 dUTPase Score = 40.9 E-value = 2.1e-09 218496004008 PS00017 ATP/GTP-binding site motif A (P-loop). 218496004009 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 218496004010 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 218496004011 E3 interaction surface; other site 218496004012 lipoyl attachment site [posttranslational modification]; other site 218496004013 e3 binding domain; Region: E3_binding; pfam02817 218496004014 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 218496004015 2-oxo acid dehydrogenases acyltransferase (catalytic domain) Score = 295.9 E-value = 3.4e-86 218496004016 e3 binding domain Score = 53.9 E-value = 2.5e-13 218496004017 Biotin-requiring enzyme Score = 69.7 E-value = 4.3e-18 218496004018 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 218496004019 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 218496004020 TPP binding site [chemical binding]; other site 218496004021 alpha subunit interface [polypeptide binding]; other site 218496004022 heterodimer interface [polypeptide binding]; other site 218496004023 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218496004024 Transketolase, C-terminal domain Score = 148.4 E-value = 9.2e-42 218496004025 Transketolase, pyridine binding domain Score = 217.9 E-value = 1.1e-62 218496004026 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 218496004027 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 218496004028 tetramer interface [polypeptide binding]; other site 218496004029 TPP-binding site [chemical binding]; other site 218496004030 heterodimer interface [polypeptide binding]; other site 218496004031 phosphorylation loop region [posttranslational modification] 218496004032 Dehydrogenase E1 component Score = 234.4 E-value = 1.2e-67 218496004033 adenylosuccinate lyase; Provisional; Region: PRK09285 218496004034 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 218496004035 tetramer interface [polypeptide binding]; other site 218496004036 active site 218496004037 Lyase Score = 110.3 E-value = 2.7e-30 218496004038 PS00163 Fumarate lyases signature. 218496004039 adenylosuccinate synthetase; Provisional; Region: PRK01117 218496004040 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 218496004041 GDP-binding site [chemical binding]; other site 218496004042 ACT binding site; other site 218496004043 IMP binding site; other site 218496004044 Adenylosuccinate synthetase Score = 715.7 E-value = 1.5e-212 218496004045 PS01266 Adenylosuccinate synthetase GTP-binding site. 218496004046 PS00513 Adenylosuccinate synthetase active site. 218496004047 Chorismate mutase type II; Region: CM_2; cl00693 218496004048 Chorismate mutase Score = 33.5 E-value = 3.3e-07 218496004049 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 218496004050 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 218496004051 dimerization interface [polypeptide binding]; other site 218496004052 ATP binding site [chemical binding]; other site 218496004053 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 218496004054 dimerization interface [polypeptide binding]; other site 218496004055 ATP binding site [chemical binding]; other site 218496004056 AIR synthase related protein, C-terminal domain Score = 53.4 E-value = 3.5e-13 218496004057 AIR synthase related protein, N-terminal domain Score = 134.3 E-value = 1.6e-37 218496004058 AIR synthase related protein, C-terminal domain Score = 147.5 E-value = 1.7e-41 218496004059 AIR synthase related protein, N-terminal domain Score = 177.1 E-value = 2.1e-50 218496004060 PS00107 Protein kinases ATP-binding region signature. 218496004061 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 218496004062 conserved cys residue [active] 218496004063 PS00442 Glutamine amidotransferases class-I active site. 218496004064 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 218496004065 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 218496004066 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 218496004067 putative ADP-binding pocket [chemical binding]; other site 218496004068 Glycosyl transferases group 1 Score = 93.9 E-value = 2.3e-25 218496004069 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 218496004070 Uncharacterized LmbE-like protein, COG2120 Score = 27.9 E-value = 3.2e-09 218496004071 Signal peptide predicted for Unknown_CDS by SignalP 2.0 HMM (Signal peptide probabilty 0.978) with cleavage site probability 0.446 between residues 43 and 44; signal peptide 218496004072 MviN-like protein; Region: MVIN; pfam03023 218496004073 14 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 7-29, 44-66, 87-106, 121-143, 156-178, 193-215, 235-257, 277-299, 320-342, 355-377, 390-412, 416-438, 459-481 and 486-508 218496004074 Virulence factor MVIN Score = 167.8 E-value = 1.3e-47 218496004075 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 218496004076 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 218496004077 active site 218496004078 NTP binding site [chemical binding]; other site 218496004079 metal binding triad [ion binding]; metal-binding site 218496004080 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 218496004081 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 218496004082 Zn2+ binding site [ion binding]; other site 218496004083 Mg2+ binding site [ion binding]; other site 218496004084 Poly A polymerase family Score = 186.8 E-value = 2.5e-53 218496004085 HD domain Score = 60.2 E-value = 3.1e-15 218496004086 ParB-like partition proteins; Region: parB_part; TIGR00180 218496004087 ParB-like nuclease domain; Region: ParBc; cl02129 218496004088 Predicted helix-turn-helix motif with score 1320.000, SD 3.68 at aa 147-168, sequence VSQDELGQTLGKSRPYVTNTIR 218496004089 ParB-like nuclease domain Score = 124.4 E-value = 1.5e-34 218496004090 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 218496004091 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 218496004092 Magnesium ion binding site [ion binding]; other site 218496004093 ParA family ATPase Score = 96.3 E-value = 4.3e-26 218496004094 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 218496004095 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 218496004096 metal-binding site [ion binding] 218496004097 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218496004098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 218496004099 8 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 79-101, 111-133, 150-172, 182-200, 330-352, 362-384, 665-684 and 688-705 218496004100 haloacid dehalogenase-like hydrolase Score = 110.6 E-value = 2.1e-30 218496004101 PS01229 Hypothetical cof family signature 2. 218496004102 PS00154 E1-E2 ATPases phosphorylation site. 218496004103 E1-E2 ATPase Score = 230.9 E-value = 1.3e-66 218496004104 Heavy-metal-associated domain Score = 53.0 E-value = 4.7e-13 218496004105 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 218496004106 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-...; Region: R3H; cd02325 218496004107 RxxxH motif; other site 218496004108 R3H domain Score = 32.1 E-value = 9.1e-07 218496004109 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 218496004110 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 218496004111 60Kd inner membrane protein Score = 175.0 E-value = 8.9e-50 218496004112 3 probable transmembrane helices predicted for Unknown_CDS by TMHMM2.0 at aa 42-64, 183-205 and 232-254 218496004113 Domain of unknown function DUF37; Region: DUF37; cl00506 218496004114 Domain of unknown function DUF37 Score = 77.8 E-value = 1.6e-20 218496004115 Ribonuclease P; Region: Ribonuclease_P; cl00457 218496004116 Ribonuclease P Score = 41.2 E-value = 1.7e-09 218496004117 PS00648 Bacterial ribonuclease P protein component signature.