-- dump date 20111121_015457 -- class Genbank::misc_feature -- table misc_feature_note -- id note 565575000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 565575000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 565575000003 Walker A motif; other site 565575000004 ATP binding site [chemical binding]; other site 565575000005 Walker B motif; other site 565575000006 arginine finger; other site 565575000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 565575000008 DnaA box-binding interface [nucleotide binding]; other site 565575000009 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 565575000010 peptide chain release factor 1; Validated; Region: prfA; PRK00591 565575000011 RF-1 domain; Region: RF-1; cl02875 565575000012 RF-1 domain; Region: RF-1; cl02875 565575000013 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 565575000014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 565575000015 S-adenosylmethionine binding site [chemical binding]; other site 565575000016 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 565575000017 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 565575000018 PQ loop repeat; Region: PQ-loop; cl12056 565575000019 PQ loop repeat; Region: PQ-loop; cl12056 565575000020 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 565575000021 MgtE intracellular N domain; Region: MgtE_N; cl15244 565575000022 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_13; cd04626 565575000023 Divalent cation transporter; Region: MgtE; cl00786 565575000024 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 565575000025 23S rRNA interface [nucleotide binding]; other site 565575000026 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 565575000027 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 565575000028 core dimer interface [polypeptide binding]; other site 565575000029 peripheral dimer interface [polypeptide binding]; other site 565575000030 L10 interface [polypeptide binding]; other site 565575000031 L11 interface [polypeptide binding]; other site 565575000032 putative EF-Tu interaction site [polypeptide binding]; other site 565575000033 putative EF-G interaction site [polypeptide binding]; other site 565575000034 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 565575000035 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 565575000036 TM-ABC transporter signature motif; other site 565575000037 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 565575000038 TM-ABC transporter signature motif; other site 565575000039 reticulocyte binding protein 2-like protein; Provisional; Region: PTZ00440 565575000040 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 565575000041 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 565575000042 Walker A/P-loop; other site 565575000043 ATP binding site [chemical binding]; other site 565575000044 Q-loop/lid; other site 565575000045 ABC transporter signature motif; other site 565575000046 Walker B; other site 565575000047 D-loop; other site 565575000048 H-loop/switch region; other site 565575000049 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 565575000050 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 565575000051 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 565575000052 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 565575000053 active site 565575000054 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 565575000055 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 565575000056 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 565575000057 G1 box; other site 565575000058 GTP/Mg2+ binding site [chemical binding]; other site 565575000059 Switch I region; other site 565575000060 G2 box; other site 565575000061 Switch II region; other site 565575000062 G3 box; other site 565575000063 G4 box; other site 565575000064 G5 box; other site 565575000065 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 565575000066 DNA polymerase III subunit delta'; Validated; Region: PRK05818 565575000067 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 565575000068 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 565575000069 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 565575000070 TMP-binding site; other site 565575000071 ATP-binding site [chemical binding]; other site 565575000072 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 565575000073 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 565575000074 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 565575000075 ABC-ATPase subunit interface; other site 565575000076 dimer interface [polypeptide binding]; other site 565575000077 putative PBP binding regions; other site 565575000078 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 565575000079 ABC-ATPase subunit interface; other site 565575000080 dimer interface [polypeptide binding]; other site 565575000081 putative PBP binding regions; other site 565575000082 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 565575000083 ABC-ATPase subunit interface; other site 565575000084 dimer interface [polypeptide binding]; other site 565575000085 putative PBP binding regions; other site 565575000086 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 565575000087 rRNA interaction site [nucleotide binding]; other site 565575000088 S8 interaction site; other site 565575000089 putative laminin-1 binding site; other site 565575000090 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 565575000091 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 565575000092 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 565575000093 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 565575000094 RNA binding site [nucleotide binding]; other site 565575000095 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 565575000096 HsdM N-terminal domain; Region: HsdM_N; pfam12161 565575000097 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 565575000098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 565575000099 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 565575000100 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 565575000101 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565575000102 ATP binding site [chemical binding]; other site 565575000103 putative Mg++ binding site [ion binding]; other site 565575000104 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 565575000105 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 565575000106 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 565575000107 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 565575000108 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 565575000109 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 565575000110 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 565575000111 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 565575000112 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 565575000113 Divergent AAA domain; Region: AAA_4; pfam04326 565575000114 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 565575000115 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 565575000116 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 565575000117 16S rRNA (guanine(527)-N(7))-methyltransferase GidB; Region: gidB; TIGR00138 565575000118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 565575000119 S-adenosylmethionine binding site [chemical binding]; other site 565575000120 PQ loop repeat; Region: PQ-loop; cl12056 565575000121 Domain of unknown function DUF31; Region: DUF31; pfam01732 565575000122 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 565575000123 Domain of unknown function DUF31; Region: DUF31; pfam01732 565575000124 Domain of unknown function DUF31; Region: DUF31; pfam01732 565575000125 Protein of unknown function (DUF2714); Region: DUF2714; pfam10896 565575000126 DNA-directed RNA polymerase, subunit A''; Region: RNA_pol_rpoA2; TIGR02389 565575000127 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 565575000128 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 565575000129 Walker A motif; other site 565575000130 ATP binding site [chemical binding]; other site 565575000131 Walker B motif; other site 565575000132 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 565575000133 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 565575000134 alpha subunit interaction interface [polypeptide binding]; other site 565575000135 Walker A motif; other site 565575000136 ATP binding site [chemical binding]; other site 565575000137 Walker B motif; other site 565575000138 inhibitor binding site; inhibition site 565575000139 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 565575000140 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 565575000141 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 565575000142 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 565575000143 putative active site [active] 565575000144 putative catalytic site [active] 565575000145 putative Mg binding site IVb [ion binding]; other site 565575000146 putative phosphate binding site [ion binding]; other site 565575000147 putative DNA binding site [nucleotide binding]; other site 565575000148 putative Mg binding site IVa [ion binding]; other site 565575000149 Preprotein translocase SecG subunit; Region: SecG; cl09123 565575000150 ribonuclease R; Region: RNase_R; TIGR02063 565575000151 RNB domain; Region: RNB; pfam00773 565575000152 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 565575000153 RNA binding site [nucleotide binding]; other site 565575000154 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 565575000155 SmpB-tmRNA interface; other site 565575000156 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565575000157 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 565575000158 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 565575000159 Walker A/P-loop; other site 565575000160 ATP binding site [chemical binding]; other site 565575000161 Q-loop/lid; other site 565575000162 ABC transporter signature motif; other site 565575000163 Walker B; other site 565575000164 D-loop; other site 565575000165 H-loop/switch region; other site 565575000166 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 565575000167 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 565575000168 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 565575000169 Walker A/P-loop; other site 565575000170 ATP binding site [chemical binding]; other site 565575000171 Q-loop/lid; other site 565575000172 ABC transporter signature motif; other site 565575000173 Walker B; other site 565575000174 D-loop; other site 565575000175 H-loop/switch region; other site 565575000176 Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ValS; COG0525 565575000177 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 565575000178 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 565575000179 dimer interface [polypeptide binding]; other site 565575000180 putative anticodon binding site; other site 565575000181 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 565575000182 motif 1; other site 565575000183 active site 565575000184 motif 2; other site 565575000185 motif 3; other site 565575000186 oligoendopeptidase F; Region: pepF; TIGR00181 565575000187 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 565575000188 active site 565575000189 Zn binding site [ion binding]; other site 565575000190 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 565575000191 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 565575000192 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 565575000193 DNA-binding site [nucleotide binding]; DNA binding site 565575000194 trigger factor; Provisional; Region: tig; PRK01490 565575000195 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 565575000196 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 565575000197 Walker A/P-loop; other site 565575000198 ATP binding site [chemical binding]; other site 565575000199 Q-loop/lid; other site 565575000200 ABC transporter signature motif; other site 565575000201 Walker B; other site 565575000202 D-loop; other site 565575000203 H-loop/switch region; other site 565575000204 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 565575000205 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 565575000206 ABC-ATPase subunit interface; other site 565575000207 dimer interface [polypeptide binding]; other site 565575000208 putative PBP binding regions; other site 565575000209 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 565575000210 Domain of unknown function DUF21; Region: DUF21; pfam01595 565575000211 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 565575000212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 565575000213 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 565575000214 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 565575000215 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 565575000216 HPr kinase/phosphorylase; Provisional; Region: PRK05428 565575000217 DRTGG domain; Region: DRTGG; cl12147 565575000218 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 565575000219 Hpr binding site; other site 565575000220 active site 565575000221 homohexamer subunit interaction site [polypeptide binding]; other site 565575000222 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 565575000223 Ligand Binding Site [chemical binding]; other site 565575000224 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 565575000225 putative active site [active] 565575000226 catalytic residue [active] 565575000227 DNA polymerase III subunit beta; Validated; Region: PRK05643 565575000228 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 565575000229 putative DNA binding surface [nucleotide binding]; other site 565575000230 dimer interface [polypeptide binding]; other site 565575000231 beta-clamp/clamp loader binding surface; other site 565575000232 beta-clamp/translesion DNA polymerase binding surface; other site 565575000233 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 565575000234 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 565575000235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 565575000236 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 565575000237 anchoring element; other site 565575000238 dimer interface [polypeptide binding]; other site 565575000239 ATP binding site [chemical binding]; other site 565575000240 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 565575000241 active site 565575000242 putative metal-binding site [ion binding]; other site 565575000243 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 565575000244 DNA gyrase subunit A; Validated; Region: PRK05560 565575000245 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 565575000246 CAP-like domain; other site 565575000247 Active site [active] 565575000248 primary dimer interface [polypeptide binding]; other site 565575000249 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565575000250 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565575000251 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565575000252 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565575000253 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565575000254 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565575000255 Competence-damaged protein; Region: CinA; cl00666 565575000256 recombinase A; Provisional; Region: recA; PRK09354 565575000257 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 565575000258 hexamer interface [polypeptide binding]; other site 565575000259 Walker A motif; other site 565575000260 ATP binding site [chemical binding]; other site 565575000261 Walker B motif; other site 565575000262 hypothetical protein; Provisional; Region: PRK12705 565575000263 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 565575000264 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 565575000265 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673 565575000266 Substrate-binding site [chemical binding]; other site 565575000267 Substrate specificity [chemical binding]; other site 565575000268 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05896 565575000269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 565575000270 Walker A motif; other site 565575000271 ATP binding site [chemical binding]; other site 565575000272 Walker B motif; other site 565575000273 arginine finger; other site 565575000274 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 565575000275 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 565575000276 RecR protein; Region: RecR; pfam02132 565575000277 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 565575000278 putative active site [active] 565575000279 putative metal-binding site [ion binding]; other site 565575000280 tetramer interface [polypeptide binding]; other site 565575000281 signal recognition particle protein; Provisional; Region: PRK10867 565575000282 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 565575000283 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 565575000284 P loop; other site 565575000285 GTP binding site [chemical binding]; other site 565575000286 Signal peptide binding domain; Region: SRP_SPB; pfam02978 565575000287 ABC-2 type transporter; Region: ABC2_membrane; cl11417 565575000288 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 565575000289 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 565575000290 Walker A/P-loop; other site 565575000291 ATP binding site [chemical binding]; other site 565575000292 Q-loop/lid; other site 565575000293 ABC transporter signature motif; other site 565575000294 Walker B; other site 565575000295 D-loop; other site 565575000296 H-loop/switch region; other site 565575000297 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 565575000298 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 565575000299 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 565575000300 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 565575000301 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 565575000302 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 565575000303 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 565575000304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 565575000305 Walker A motif; other site 565575000306 ATP binding site [chemical binding]; other site 565575000307 Walker B motif; other site 565575000308 arginine finger; other site 565575000309 Peptidase family M41; Region: Peptidase_M41; pfam01434 565575000310 seryl-tRNA synthetase; Provisional; Region: PRK05431 565575000311 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 565575000312 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 565575000313 dimer interface [polypeptide binding]; other site 565575000314 active site 565575000315 motif 1; other site 565575000316 motif 2; other site 565575000317 motif 3; other site 565575000318 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 565575000319 Walker A/P-loop; other site 565575000320 ATP binding site [chemical binding]; other site 565575000321 Q-loop/lid; other site 565575000322 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 565575000323 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 565575000324 ABC transporter signature motif; other site 565575000325 Walker B; other site 565575000326 D-loop; other site 565575000327 H-loop/switch region; other site 565575000328 TOBE domain; Region: TOBE_2; cl01440 565575000329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 565575000330 dimer interface [polypeptide binding]; other site 565575000331 conserved gate region; other site 565575000332 putative PBP binding loops; other site 565575000333 ABC-ATPase subunit interface; other site 565575000334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 565575000335 dimer interface [polypeptide binding]; other site 565575000336 conserved gate region; other site 565575000337 putative PBP binding loops; other site 565575000338 ABC-ATPase subunit interface; other site 565575000339 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 565575000340 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 565575000341 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 565575000342 active site 565575000343 catalytic site [active] 565575000344 substrate binding site [chemical binding]; other site 565575000345 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 565575000346 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 565575000347 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 565575000348 active site 565575000349 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 565575000350 folate binding site [chemical binding]; other site 565575000351 NADP+ binding site [chemical binding]; other site 565575000352 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 565575000353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 565575000354 motif II; other site 565575000355 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 565575000356 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 565575000357 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 565575000358 active site 565575000359 HIGH motif; other site 565575000360 dimer interface [polypeptide binding]; other site 565575000361 KMSKS motif; other site 565575000362 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 565575000363 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 565575000364 Walker A/P-loop; other site 565575000365 ATP binding site [chemical binding]; other site 565575000366 Q-loop/lid; other site 565575000367 ABC transporter signature motif; other site 565575000368 Walker B; other site 565575000369 D-loop; other site 565575000370 H-loop/switch region; other site 565575000371 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 565575000372 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 565575000373 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 565575000374 excinuclease ABC subunit B; Provisional; Region: PRK05298 565575000375 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 565575000376 ATP binding site [chemical binding]; other site 565575000377 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565575000378 nucleotide binding region [chemical binding]; other site 565575000379 ATP-binding site [chemical binding]; other site 565575000380 Ultra-violet resistance protein B; Region: UvrB; pfam12344 565575000381 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 565575000382 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 565575000383 nucleotide binding pocket [chemical binding]; other site 565575000384 K-X-D-G motif; other site 565575000385 catalytic site [active] 565575000386 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 565575000387 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 565575000388 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 565575000389 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cl00038 565575000390 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 565575000391 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 565575000392 active site 565575000393 HIGH motif; other site 565575000394 nucleotide binding site [chemical binding]; other site 565575000395 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 565575000396 KMSKS motif; other site 565575000397 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 565575000398 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 565575000399 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 565575000400 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 565575000401 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 565575000402 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 565575000403 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 565575000404 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 565575000405 alpha subunit interaction interface [polypeptide binding]; other site 565575000406 Walker A motif; other site 565575000407 ATP binding site [chemical binding]; other site 565575000408 Walker B motif; other site 565575000409 inhibitor binding site; inhibition site 565575000410 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 565575000411 ATP synthase; Region: ATP-synt; cl00365 565575000412 2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding; Region: PLN02980 565575000413 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 565575000414 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 565575000415 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 565575000416 beta subunit interaction interface [polypeptide binding]; other site 565575000417 Walker A motif; other site 565575000418 ATP binding site [chemical binding]; other site 565575000419 Walker B motif; other site 565575000420 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 565575000421 Uncharacterized conserved protein [Function unknown]; Region: COG4933 565575000422 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 565575000423 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 565575000424 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 565575000425 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 565575000426 ATP synthase subunit C; Region: ATP-synt_C; cl00466 565575000427 ATP synthase A chain; Region: ATP-synt_A; cl00413 565575000428 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 565575000429 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 565575000430 Walker A/P-loop; other site 565575000431 ATP binding site [chemical binding]; other site 565575000432 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 565575000433 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 565575000434 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 565575000435 Q-loop/lid; other site 565575000436 ABC transporter signature motif; other site 565575000437 Walker B; other site 565575000438 D-loop; other site 565575000439 H-loop/switch region; other site 565575000440 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 565575000441 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 565575000442 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 565575000443 GTP binding site [chemical binding]; other site 565575000444 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 565575000445 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 565575000446 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07133 565575000447 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 565575000448 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 565575000449 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 565575000450 active site 565575000451 motif I; other site 565575000452 motif II; other site 565575000453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 565575000454 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 565575000455 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 565575000456 active site 565575000457 HIGH motif; other site 565575000458 dimer interface [polypeptide binding]; other site 565575000459 KMSKS motif; other site 565575000460 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting...; Region: ArsC_Spx; cd03032 565575000461 putative catalytic residues [active] 565575000462 thiol/disulfide switch; other site 565575000463 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 565575000464 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cl00164 565575000465 active site turn [active] 565575000466 phosphorylation site [posttranslational modification] 565575000467 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 565575000468 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 565575000469 substrate binding site [chemical binding]; other site 565575000470 dimer interface [polypeptide binding]; other site 565575000471 catalytic triad [active] 565575000472 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 565575000473 Sulfatase; Region: Sulfatase; cl10460 565575000474 enolase; Provisional; Region: eno; PRK00077 565575000475 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 565575000476 dimer interface [polypeptide binding]; other site 565575000477 metal binding site [ion binding]; metal-binding site 565575000478 substrate binding pocket [chemical binding]; other site 565575000479 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 565575000480 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 565575000481 active site 565575000482 ADP/pyrophosphate binding site [chemical binding]; other site 565575000483 dimerization interface [polypeptide binding]; other site 565575000484 allosteric effector site; other site 565575000485 fructose-1,6-bisphosphate binding site; other site 565575000486 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 565575000487 domain interfaces; other site 565575000488 active site 565575000489 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 565575000490 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 565575000491 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 565575000492 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 565575000493 RPB10 interaction site [polypeptide binding]; other site 565575000494 RPB11 interaction site [polypeptide binding]; other site 565575000495 RPB3 interaction site [polypeptide binding]; other site 565575000496 RPB12 interaction site [polypeptide binding]; other site 565575000497 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 565575000498 RPB1 interaction site [polypeptide binding]; other site 565575000499 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 565575000500 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 565575000501 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 565575000502 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 565575000503 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 565575000504 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 565575000505 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 565575000506 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 565575000507 DNA binding site [nucleotide binding] 565575000508 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 565575000509 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 565575000510 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 565575000511 putative tRNA-binding site [nucleotide binding]; other site 565575000512 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 565575000513 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 565575000514 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 565575000515 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in...; Region: TOPRIM_RNase_M5_like; cd01027 565575000516 putative active site [active] 565575000517 putative metal binding site [ion binding]; other site 565575000518 Predicted methyltransferases [General function prediction only]; Region: COG0313 565575000519 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 565575000520 recombination factor protein RarA; Reviewed; Region: PRK13342 565575000521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 565575000522 Walker A motif; other site 565575000523 ATP binding site [chemical binding]; other site 565575000524 Walker B motif; other site 565575000525 arginine finger; other site 565575000526 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 565575000527 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 565575000528 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 565575000529 active site 565575000530 HIGH motif; other site 565575000531 KMSKS motif; other site 565575000532 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 565575000533 tRNA binding surface [nucleotide binding]; other site 565575000534 anticodon binding site; other site 565575000535 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 565575000536 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 565575000537 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 565575000538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 565575000539 dimer interface [polypeptide binding]; other site 565575000540 conserved gate region; other site 565575000541 putative PBP binding loops; other site 565575000542 ABC-ATPase subunit interface; other site 565575000543 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14257 565575000544 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 565575000545 Walker A/P-loop; other site 565575000546 ATP binding site [chemical binding]; other site 565575000547 Q-loop/lid; other site 565575000548 ABC transporter signature motif; other site 565575000549 Walker B; other site 565575000550 D-loop; other site 565575000551 H-loop/switch region; other site 565575000552 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 565575000553 PhoU domain; Region: PhoU; pfam01895 565575000554 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 565575000555 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 565575000556 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565575000557 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 565575000558 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 565575000559 16S/18S rRNA binding site [nucleotide binding]; other site 565575000560 S13e-L30e interaction site [polypeptide binding]; other site 565575000561 25S rRNA binding site [nucleotide binding]; other site 565575000562 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 565575000563 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 565575000564 dimerization interface [polypeptide binding]; other site 565575000565 active site 565575000566 metal binding site [ion binding]; metal-binding site 565575000567 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 565575000568 dsRNA binding site [nucleotide binding]; other site 565575000569 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 565575000570 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 565575000571 DAK2 domain; Region: Dak2; cl03685 565575000572 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 565575000573 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 565575000574 Protein of unknown function (DUF464); Region: DUF464; cl01080 565575000575 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 565575000576 Ribosomal protein L21 leader 565575000577 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 565575000578 catalytic site [active] 565575000579 G-X2-G-X-G-K; other site 565575000580 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 565575000581 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 565575000582 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 565575000583 Active site [active] 565575000584 Catalytic domain of Protein Kinases; Region: PKc; cd00180 565575000585 active site 565575000586 ATP binding site [chemical binding]; other site 565575000587 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 565575000588 substrate binding site [chemical binding]; other site 565575000589 activation loop (A-loop); other site 565575000590 Predicted GTPases [General function prediction only]; Region: COG1162 565575000591 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 565575000592 GTPase/OB domain interface [polypeptide binding]; other site 565575000593 GTPase/Zn-binding domain interface [polypeptide binding]; other site 565575000594 GTP/Mg2+ binding site [chemical binding]; other site 565575000595 G4 box; other site 565575000596 G5 box; other site 565575000597 G1 box; other site 565575000598 Switch I region; other site 565575000599 G2 box; other site 565575000600 G3 box; other site 565575000601 Switch II region; other site 565575000602 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 565575000603 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 565575000604 Domain of unknown function (DUF368); Region: DUF368; cl00893 565575000605 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 565575000606 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 565575000607 Potassium binding sites [ion binding]; other site 565575000608 Cesium cation binding sites [ion binding]; other site 565575000609 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 565575000610 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 565575000611 DNA binding site [nucleotide binding] 565575000612 Int/Topo IB signature motif; other site 565575000613 active site 565575000614 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 565575000615 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 565575000616 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 565575000617 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 565575000618 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 565575000619 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 565575000620 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 565575000621 23S rRNA binding site [nucleotide binding]; other site 565575000622 L21 binding site [polypeptide binding]; other site 565575000623 L13 binding site [polypeptide binding]; other site 565575000624 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 565575000625 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 565575000626 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 565575000627 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 565575000628 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 565575000629 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 565575000630 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 565575000631 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 565575000632 50S ribosomal protein L22/unknown domain fusion protein; Provisional; Region: PRK12279 565575000633 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 565575000634 putative translocon binding site; other site 565575000635 protein-rRNA interface [nucleotide binding]; other site 565575000636 Uncharacterized conserved protein [Function unknown]; Region: COG4933 565575000637 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 565575000638 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 565575000639 G-X-X-G motif; other site 565575000640 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 565575000641 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 565575000642 23S rRNA interface [nucleotide binding]; other site 565575000643 5S rRNA interface [nucleotide binding]; other site 565575000644 putative antibiotic binding site [chemical binding]; other site 565575000645 L25 interface [polypeptide binding]; other site 565575000646 L27 interface [polypeptide binding]; other site 565575000647 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cl09943 565575000648 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 565575000649 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 565575000650 KOW motif; Region: KOW; cl00354 565575000651 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 565575000652 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 565575000653 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 565575000654 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 565575000655 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 565575000656 ribosomal protein L6, bacterial type; Region: L6_bact; TIGR03654 565575000657 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 565575000658 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 565575000659 5S rRNA interface [nucleotide binding]; other site 565575000660 L27 interface [polypeptide binding]; other site 565575000661 23S rRNA interface [nucleotide binding]; other site 565575000662 L5 interface [polypeptide binding]; other site 565575000663 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 565575000664 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 565575000665 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 565575000666 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 565575000667 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 565575000668 SecY translocase; Region: SecY; pfam00344 565575000669 adenylate kinases; Region: adk; TIGR01351 565575000670 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 565575000671 AMP-binding site [chemical binding]; other site 565575000672 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 565575000673 methionine aminopeptidase; Reviewed; Region: PRK07281 565575000674 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 565575000675 active site 565575000676 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 565575000677 rRNA binding site [nucleotide binding]; other site 565575000678 predicted 30S ribosome binding site; other site 565575000679 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 565575000680 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 565575000681 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 565575000682 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 565575000683 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 565575000684 alphaNTD homodimer interface [polypeptide binding]; other site 565575000685 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 565575000686 alphaNTD - beta interaction site [polypeptide binding]; other site 565575000687 alphaNTD - beta' interaction site [polypeptide binding]; other site 565575000688 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 565575000689 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 565575000690 Uncharacterized conserved protein [Function unknown]; Region: COG1739 565575000691 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 565575000692 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 565575000693 HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 565575000694 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 565575000695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 565575000696 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 565575000697 Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536 565575000698 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 565575000699 G1 box; other site 565575000700 GTP/Mg2+ binding site [chemical binding]; other site 565575000701 Switch I region; other site 565575000702 G2 box; other site 565575000703 G3 box; other site 565575000704 Switch II region; other site 565575000705 G4 box; other site 565575000706 G5 box; other site 565575000707 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 565575000708 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 565575000709 active site 565575000710 HIGH motif; other site 565575000711 nucleotide binding site [chemical binding]; other site 565575000712 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 565575000713 active site 565575000714 KMSKS motif; other site 565575000715 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 565575000716 tRNA binding surface [nucleotide binding]; other site 565575000717 anticodon binding site; other site 565575000718 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 565575000719 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 565575000720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 565575000721 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 565575000722 HIT family signature motif; other site 565575000723 catalytic residue [active] 565575000724 coproporphyrinogen III oxidase; Provisional; Region: PRK05904 565575000725 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 565575000726 HemN C-terminal region; Region: HemN_C; pfam06969 565575000727 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 565575000728 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_B; cd01571 565575000729 active site 565575000730 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 565575000731 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 565575000732 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 565575000733 active site 565575000734 HIGH motif; other site 565575000735 KMSK motif region; other site 565575000736 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 565575000737 tRNA binding surface [nucleotide binding]; other site 565575000738 anticodon binding site; other site 565575000739 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 565575000740 substrate binding site [chemical binding]; other site 565575000741 hinge regions; other site 565575000742 ADP binding site [chemical binding]; other site 565575000743 catalytic site [active] 565575000744 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 565575000745 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 565575000746 oligomer interface [polypeptide binding]; other site 565575000747 active site 565575000748 metal binding site [ion binding]; metal-binding site 565575000749 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 565575000750 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 565575000751 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 565575000752 IHF - DNA interface [nucleotide binding]; other site 565575000753 IHF dimer interface [polypeptide binding]; other site 565575000754 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 565575000755 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 565575000756 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 565575000757 synthetase active site [active] 565575000758 NTP binding site [chemical binding]; other site 565575000759 metal binding site [ion binding]; metal-binding site 565575000760 CTP synthetase; Validated; Region: pyrG; PRK05380 565575000761 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 565575000762 Catalytic site [active] 565575000763 Active site [active] 565575000764 UTP binding site [chemical binding]; other site 565575000765 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 565575000766 active site 565575000767 putative oxyanion hole; other site 565575000768 catalytic triad [active] 565575000769 histidyl-tRNA synthetase; Region: hisS; TIGR00442 565575000770 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 565575000771 dimer interface [polypeptide binding]; other site 565575000772 motif 1; other site 565575000773 active site 565575000774 motif 2; other site 565575000775 motif 3; other site 565575000776 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266 565575000777 anticodon binding site; other site 565575000778 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 565575000779 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 565575000780 dimer interface [polypeptide binding]; other site 565575000781 anticodon binding site; other site 565575000782 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 565575000783 homodimer interface [polypeptide binding]; other site 565575000784 motif 1; other site 565575000785 active site 565575000786 motif 2; other site 565575000787 GAD domain; Region: GAD; pfam02938 565575000788 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 565575000789 motif 3; other site 565575000790 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 565575000791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 565575000792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 565575000793 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 565575000794 catalytic residues [active] 565575000795 dimer interface [polypeptide binding]; other site 565575000796 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 565575000797 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 565575000798 active site 565575000799 catalytic triad [active] 565575000800 oxyanion hole [active] 565575000801 Domain of unknown function DUF28; Region: DUF28; cl00361 565575000802 translation elongation factor P; Region: efp; TIGR00038 565575000803 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 565575000804 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 565575000805 RNA binding site [nucleotide binding]; other site 565575000806 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 565575000807 RNA binding site [nucleotide binding]; other site 565575000808 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 565575000809 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 565575000810 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 565575000811 domain; Region: GreA_GreB_N; pfam03449 565575000812 C-term; Region: GreA_GreB; pfam01272 565575000813 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 565575000814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 565575000815 S-adenosylmethionine binding site [chemical binding]; other site 565575000816 endonuclease IV; Provisional; Region: PRK01060 565575000817 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 565575000818 AP (apurinic/apyrimidinic) site pocket; other site 565575000819 DNA interaction; other site 565575000820 Metal-binding active site; metal-binding site 565575000821 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 565575000822 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 565575000823 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 565575000824 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 565575000825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 565575000826 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 565575000827 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 565575000828 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565575000829 RNA binding surface [nucleotide binding]; other site 565575000830 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 565575000831 active site 565575000832 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 565575000833 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 565575000834 dimer interface [polypeptide binding]; other site 565575000835 substrate binding site [chemical binding]; other site 565575000836 metal binding sites [ion binding]; metal-binding site 565575000837 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 565575000838 conserved cys residue [active] 565575000839 FtsX-like permease family; Region: FtsX; pfam02687 565575000840 transcription termination factor NusA; Region: NusA; TIGR01953 565575000841 NusA N-terminal domain; Region: NusA_N; pfam08529 565575000842 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 565575000843 G-X-X-G motif; other site 565575000844 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 565575000845 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 565575000846 translation initiation factor IF-2; Region: IF-2; TIGR00487 565575000847 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 565575000848 G1 box; other site 565575000849 putative GEF interaction site [polypeptide binding]; other site 565575000850 GTP/Mg2+ binding site [chemical binding]; other site 565575000851 Switch I region; other site 565575000852 G2 box; other site 565575000853 G3 box; other site 565575000854 Switch II region; other site 565575000855 G4 box; other site 565575000856 G5 box; other site 565575000857 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 565575000858 Translation-initiation factor 2; Region: IF-2; pfam11987 565575000859 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 565575000860 Ribosome-binding factor A; Region: RBFA; cl00542 565575000861 Protein of unknown function DUF45; Region: DUF45; cl00636 565575000862 GTP-binding protein LepA; Provisional; Region: PRK05433 565575000863 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 565575000864 G1 box; other site 565575000865 putative GEF interaction site [polypeptide binding]; other site 565575000866 GTP/Mg2+ binding site [chemical binding]; other site 565575000867 Switch I region; other site 565575000868 G2 box; other site 565575000869 G3 box; other site 565575000870 Switch II region; other site 565575000871 G4 box; other site 565575000872 G5 box; other site 565575000873 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 565575000874 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 565575000875 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 565575000876 LemA family; Region: LemA; cl00742 565575000877 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 565575000878 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 565575000879 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 565575000880 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 565575000881 hypothetical protein; Provisional; Region: PRK09609 565575000882 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 565575000883 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 565575000884 ATP-binding site [chemical binding]; other site 565575000885 Sugar specificity; other site 565575000886 Pyrimidine base specificity; other site 565575000887 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 565575000888 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 565575000889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 565575000890 NAD(P) binding pocket [chemical binding]; other site 565575000891 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 565575000892 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 565575000893 substrate binding site [chemical binding]; other site 565575000894 cytidylate kinase; Provisional; Region: cmk; PRK00023 565575000895 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 565575000896 CMP-binding site; other site 565575000897 The sites determining sugar specificity; other site 565575000898 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 565575000899 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 565575000900 putative acyl-acceptor binding pocket; other site 565575000901 ScpA/B protein; Region: ScpA_ScpB; cl00598 565575000902 DNA polymerase III PolC; Validated; Region: polC; PRK00448 565575000903 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 565575000904 trigger factor; Region: tig; TIGR00115 565575000905 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 565575000906 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 565575000907 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 565575000908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 565575000909 Walker A motif; other site 565575000910 ATP binding site [chemical binding]; other site 565575000911 Walker B motif; other site 565575000912 arginine finger; other site 565575000913 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 565575000914 RNA polymerase sigma factor; Provisional; Region: PRK05901 565575000915 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 565575000916 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 565575000917 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 565575000918 DNA binding residues [nucleotide binding] 565575000919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 565575000920 Uncharacterized conserved protein [Function unknown]; Region: COG0327 565575000921 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 565575000922 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 565575000923 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 565575000924 RNA binding site [nucleotide binding]; other site 565575000925 active site 565575000926 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 565575000927 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 565575000928 active site 565575000929 nucleotide binding site [chemical binding]; other site 565575000930 HIGH motif; other site 565575000931 KMSKS motif; other site 565575000932 Riboflavin kinase; Region: Flavokinase; pfam01687 565575000933 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 565575000934 ABC-ATPase subunit interface; other site 565575000935 dimer interface [polypeptide binding]; other site 565575000936 putative PBP binding regions; other site 565575000937 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 565575000938 ABC-ATPase subunit interface; other site 565575000939 dimer interface [polypeptide binding]; other site 565575000940 putative PBP binding regions; other site 565575000941 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 565575000942 ABC-ATPase subunit interface; other site 565575000943 dimer interface [polypeptide binding]; other site 565575000944 putative PBP binding regions; other site 565575000945 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 565575000946 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 565575000947 tetrameric interface [polypeptide binding]; other site 565575000948 activator binding site; other site 565575000949 NADP binding site [chemical binding]; other site 565575000950 substrate binding site [chemical binding]; other site 565575000951 catalytic residues [active] 565575000952 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 565575000953 dimer interface [polypeptide binding]; other site 565575000954 active site 565575000955 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 565575000956 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 565575000957 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318 565575000958 putative dimer interface [polypeptide binding]; other site 565575000959 putative anticodon binding site; other site 565575000960 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 565575000961 homodimer interface [polypeptide binding]; other site 565575000962 motif 1; other site 565575000963 motif 2; other site 565575000964 active site 565575000965 motif 3; other site 565575000966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 565575000967 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 565575000968 Thymidine phosphorylase [Nucleotide transport and metabolism]; Region: DeoA; COG0213 565575000969 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 565575000970 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 565575000971 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 565575000972 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 565575000973 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 565575000974 motif 1; other site 565575000975 active site 565575000976 motif 2; other site 565575000977 motif 3; other site 565575000978 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 565575000979 DHHA1 domain; Region: DHHA1; pfam02272 565575000980 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 565575000981 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 565575000982 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 565575000983 HIGH motif; other site 565575000984 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 565575000985 active site 565575000986 KMSKS motif; other site 565575000987 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 565575000988 tRNA binding surface [nucleotide binding]; other site 565575000989 Phage terminase large subunit; Region: Terminase_3; cl12054 565575000990 Terminase-like family; Region: Terminase_6; pfam03237 565575000991 phosphodiesterase; Provisional; Region: PRK12704 565575000992 RecT family; Region: RecT; cl04285 565575000993 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 565575000994 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 565575000995 DNA binding site [nucleotide binding] 565575000996 Int/Topo IB signature motif; other site 565575000997 active site 565575000998 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 565575000999 DNA polymerase III PolC; Validated; Region: polC; PRK00448 565575001000 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 565575001001 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 565575001002 active site 565575001003 substrate binding site [chemical binding]; other site 565575001004 catalytic site [active] 565575001005 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 565575001006 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 565575001007 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 565575001008 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 565575001009 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 565575001010 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 565575001011 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 565575001012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 565575001013 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 565575001014 GTP-binding protein Der; Reviewed; Region: PRK00093 565575001015 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 565575001016 G1 box; other site 565575001017 GTP/Mg2+ binding site [chemical binding]; other site 565575001018 Switch I region; other site 565575001019 G2 box; other site 565575001020 Switch II region; other site 565575001021 G3 box; other site 565575001022 G4 box; other site 565575001023 G5 box; other site 565575001024 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 565575001025 G1 box; other site 565575001026 GTP/Mg2+ binding site [chemical binding]; other site 565575001027 Switch I region; other site 565575001028 G2 box; other site 565575001029 G3 box; other site 565575001030 Switch II region; other site 565575001031 G4 box; other site 565575001032 G5 box; other site 565575001033 Competence protein; Region: Competence; cl00471 565575001034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 565575001035 MraZ protein; Region: MraZ; pfam02381 565575001036 MraZ protein; Region: MraZ; pfam02381 565575001037 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 565575001038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 565575001039 Abi-like protein; Region: Abi_2; cl01988 565575001040 DNA helicase, putative; Region: TIGR00376 565575001041 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 565575001042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 565575001043 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 565575001044 Walker A motif; other site 565575001045 ATP binding site [chemical binding]; other site 565575001046 Walker B motif; other site 565575001047 arginine finger; other site 565575001048 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 565575001049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 565575001050 Walker A motif; other site 565575001051 ATP binding site [chemical binding]; other site 565575001052 Walker B motif; other site 565575001053 arginine finger; other site 565575001054 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 565575001055 ABC-2 type transporter; Region: ABC2_membrane; cl11417 565575001056 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 565575001057 DivIVA protein; Region: DivIVA; pfam05103 565575001058 Ribonuclease HIII [DNA replication, recombination, and repair]; Region: RnhC; COG1039 565575001059 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 565575001060 RNA/DNA hybrid binding site [nucleotide binding]; other site 565575001061 active site 565575001062 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 565575001063 ABC-ATPase subunit interface; other site 565575001064 dimer interface [polypeptide binding]; other site 565575001065 putative PBP binding regions; other site 565575001066 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 565575001067 ABC-ATPase subunit interface; other site 565575001068 dimer interface [polypeptide binding]; other site 565575001069 putative PBP binding regions; other site 565575001070 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 565575001071 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 565575001072 Ligand Binding Site [chemical binding]; other site 565575001073 Transposase, Mutator family; Region: Transposase_mut; pfam00872 565575001074 Domain of unknown function (DUF205); Region: DUF205; cl00410 565575001075 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 565575001076 dimer interface [polypeptide binding]; other site 565575001077 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 565575001078 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 565575001079 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 565575001080 HSP70 interaction site [polypeptide binding]; other site 565575001081 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 565575001082 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 565575001083 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 565575001084 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 565575001085 active site 565575001086 HIGH motif; other site 565575001087 nucleotide binding site [chemical binding]; other site 565575001088 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 565575001089 active site 565575001090 KMSKS motif; other site 565575001091 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 565575001092 tRNA binding surface [nucleotide binding]; other site 565575001093 anticodon binding site; other site 565575001094 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 565575001095 UGMP family protein; Validated; Region: PRK09604 565575001096 S-adenosylmethionine synthetase; Validated; Region: PRK05250 565575001097 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 565575001098 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 565575001099 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 565575001100 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 565575001101 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 565575001102 DNA binding site [nucleotide binding] 565575001103 catalytic residue [active] 565575001104 H2TH interface [polypeptide binding]; other site 565575001105 putative catalytic residues [active] 565575001106 turnover-facilitating residue; other site 565575001107 intercalation triad [nucleotide binding]; other site 565575001108 8OG recognition residue [nucleotide binding]; other site 565575001109 putative reading head residues; other site 565575001110 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 565575001111 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 565575001112 5'-3' exonuclease; Provisional; Region: PRK14976 565575001113 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 565575001114 active site 565575001115 metal binding site 1 [ion binding]; metal-binding site 565575001116 putative 5' ssDNA interaction site; other site 565575001117 metal binding site 3; metal-binding site 565575001118 metal binding site 2 [ion binding]; metal-binding site 565575001119 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 565575001120 putative DNA binding site [nucleotide binding]; other site 565575001121 putative metal binding site [ion binding]; other site 565575001122 DNA polymerase III DnaE; Validated; Region: dnaE; PRK05898 565575001123 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 565575001124 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 565575001125 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 565575001126 DHH family; Region: DHH; pfam01368 565575001127 DHHA1 domain; Region: DHHA1; pfam02272 565575001128 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 565575001129 THUMP domain; Region: THUMP; cl12076 565575001130 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 565575001131 Ligand Binding Site [chemical binding]; other site 565575001132 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 565575001133 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 565575001134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 565575001135 HrcA protein C terminal domain; Region: HrcA; pfam01628 565575001136 Protein of unknown function (DUF402); Region: DUF402; cl00979 565575001137 Protein of unknown function (DUF3196); Region: DUF3196; pfam11428 565575001138 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 565575001139 Ferritin-like domain; Region: Ferritin; pfam00210 565575001140 dinuclear metal binding motif [ion binding]; other site 565575001141 UreD urease accessory protein; Region: UreD; cl00530 565575001142 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 565575001143 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 565575001144 UreF; Region: UreF; pfam01730 565575001145 urease accessory protein UreE; Provisional; Region: PRK14112 565575001146 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-...; Region: UreE; cd00571 565575001147 dimer interface [polypeptide binding]; other site 565575001148 catalytic residues [active] 565575001149 urease subunit alpha; Reviewed; Region: ureC; PRK13207 565575001150 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 565575001151 subunit interactions [polypeptide binding]; other site 565575001152 active site 565575001153 flap region; other site 565575001154 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 565575001155 gamma-beta subunit interface [polypeptide binding]; other site 565575001156 alpha-beta subunit interface [polypeptide binding]; other site 565575001157 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 565575001158 alpha-gamma subunit interface [polypeptide binding]; other site 565575001159 beta-gamma subunit interface [polypeptide binding]; other site 565575001160 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 565575001161 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 565575001162 Walker A/P-loop; other site 565575001163 ATP binding site [chemical binding]; other site 565575001164 Q-loop/lid; other site 565575001165 ABC transporter signature motif; other site 565575001166 Walker B; other site 565575001167 D-loop; other site 565575001168 H-loop/switch region; other site 565575001169 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 565575001170 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565575001171 RNA binding surface [nucleotide binding]; other site 565575001172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 565575001173 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 565575001174 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 565575001175 active site 565575001176 DNA binding site [nucleotide binding] 565575001177 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 565575001178 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 565575001179 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 565575001180 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 565575001181 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 565575001182 Predicted integral membrane protein [Function unknown]; Region: COG0392 565575001183 prolyl-tRNA synthetase; Provisional; Region: PRK08661 565575001184 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_arch_euk; cd00778 565575001185 dimer interface [polypeptide binding]; other site 565575001186 motif 1; other site 565575001187 active site 565575001188 motif 2; other site 565575001189 motif 3; other site 565575001190 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266 565575001191 anticodon binding site; other site 565575001192 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 565575001193 trimerization site [polypeptide binding]; other site 565575001194 active site 565575001195 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 565575001196 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 565575001197 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 565575001198 catalytic residue [active] 565575001199 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 565575001200 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 565575001201 substrate binding site [chemical binding]; other site 565575001202 hexamer interface [polypeptide binding]; other site 565575001203 metal binding site [ion binding]; metal-binding site 565575001204 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 565575001205 active site 565575001206 catalytic triad [active] 565575001207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 565575001208 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 565575001209 Walker A motif; other site 565575001210 ATP binding site [chemical binding]; other site 565575001211 Walker B motif; other site 565575001212 arginine finger; other site 565575001213 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 565575001214 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 565575001215 putative tRNA-binding site [nucleotide binding]; other site 565575001216 B3/4 domain; Region: B3_4; cl11458 565575001217 tRNA synthetase B5 domain; Region: B5; cl08394 565575001218 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 565575001219 dimer interface [polypeptide binding]; other site 565575001220 motif 1; other site 565575001221 motif 3; other site 565575001222 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 565575001223 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 565575001224 dimer interface [polypeptide binding]; other site 565575001225 motif 1; other site 565575001226 active site 565575001227 motif 2; other site 565575001228 motif 3; other site 565575001229 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 565575001230 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 565575001231 homodimer interface [polypeptide binding]; other site 565575001232 NAD binding pocket [chemical binding]; other site 565575001233 ATP binding pocket [chemical binding]; other site 565575001234 Mg binding site [ion binding]; other site 565575001235 active-site loop [active] 565575001236 GTPase CgtA; Reviewed; Region: obgE; PRK12297 565575001237 GTP1/OBG; Region: GTP1_OBG; pfam01018 565575001238 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 565575001239 G1 box; other site 565575001240 GTP/Mg2+ binding site [chemical binding]; other site 565575001241 Switch I region; other site 565575001242 G2 box; other site 565575001243 G3 box; other site 565575001244 Switch II region; other site 565575001245 G4 box; other site 565575001246 G5 box; other site 565575001247 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 565575001248 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 565575001249 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 565575001250 putative active site [active] 565575001251 substrate binding site [chemical binding]; other site 565575001252 putative cosubstrate binding site; other site 565575001253 catalytic site [active] 565575001254 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 565575001255 substrate binding site [chemical binding]; other site 565575001256 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 565575001257 active site 565575001258 catalytic residues [active] 565575001259 metal binding site [ion binding]; metal-binding site 565575001260 Gram-positive; Region: parC_Gpos; TIGR01061 565575001261 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 565575001262 CAP-like domain; other site 565575001263 Active site [active] 565575001264 primary dimer interface [polypeptide binding]; other site 565575001265 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565575001266 DUF1410 domain; Region: DUF1410; pfam07198 565575001267 DUF1410 domain; Region: DUF1410; pfam07198 565575001268 DUF1410 domain; Region: DUF1410; pfam07198 565575001269 DUF1410 domain; Region: DUF1410; pfam07198 565575001270 DUF1410 domain; Region: DUF1410; pfam07198 565575001271 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 565575001272 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 565575001273 active site 565575001274 catalytic residues [active] 565575001275 metal binding site [ion binding]; metal-binding site 565575001276 Gram-positive; Region: parE_Gpos; TIGR01058 565575001277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 565575001278 ATP binding site [chemical binding]; other site 565575001279 Mg2+ binding site [ion binding]; other site 565575001280 G-X-G motif; other site 565575001281 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 565575001282 anchoring element; other site 565575001283 dimer interface [polypeptide binding]; other site 565575001284 ATP binding site [chemical binding]; other site 565575001285 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 565575001286 active site 565575001287 putative metal-binding site [ion binding]; other site 565575001288 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 565575001289 Gram-positive; Region: parC_Gpos; TIGR01061 565575001290 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 565575001291 CAP-like domain; other site 565575001292 Active site [active] 565575001293 primary dimer interface [polypeptide binding]; other site 565575001294 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 565575001295 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 565575001296 YqeH. YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855 565575001297 GTP/Mg2+ binding site [chemical binding]; other site 565575001298 G4 box; other site 565575001299 G5 box; other site 565575001300 G1 box; other site 565575001301 Switch I region; other site 565575001302 G2 box; other site 565575001303 G3 box; other site 565575001304 Switch II region; other site 565575001305 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 565575001306 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 565575001307 active site 565575001308 (T/H)XGH motif; other site 565575001309 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 565575001310 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 565575001311 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164 565575001312 DUF1410 domain; Region: DUF1410; pfam07198 565575001313 DUF1410 domain; Region: DUF1410; pfam07198 565575001314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 565575001315 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 565575001316 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 565575001317 DUF1410 domain; Region: DUF1410; pfam07198 565575001318 DUF1410 domain; Region: DUF1410; pfam07198 565575001319 DUF1410 domain; Region: DUF1410; pfam07198 565575001320 DUF1410 domain; Region: DUF1410; pfam07198 565575001321 DUF1410 domain; Region: DUF1410; pfam07198 565575001322 Acetokinase family; Region: Acetate_kinase; cl01029 565575001323 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 565575001324 putative active site [active] 565575001325 putative catalytic site [active] 565575001326 putative Mg binding site IVb [ion binding]; other site 565575001327 putative phosphate binding site [ion binding]; other site 565575001328 putative DNA binding site [nucleotide binding]; other site 565575001329 putative Mg binding site IVa [ion binding]; other site 565575001330 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 565575001331 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 565575001332 anticodon binding site; other site 565575001333 DUF1410 domain; Region: DUF1410; pfam07198 565575001334 DUF1410 domain; Region: DUF1410; pfam07198 565575001335 DUF1410 domain; Region: DUF1410; pfam07198 565575001336 DUF1410 domain; Region: DUF1410; pfam07198 565575001337 Transposase, Mutator family; Region: Transposase_mut; pfam00872 565575001338 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 565575001339 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 565575001340 GTPase [General function prediction only]; Region: Era; COG1159 565575001341 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 565575001342 G1 box; other site 565575001343 GTP/Mg2+ binding site [chemical binding]; other site 565575001344 Switch I region; other site 565575001345 G2 box; other site 565575001346 Switch II region; other site 565575001347 G3 box; other site 565575001348 G4 box; other site 565575001349 G5 box; other site 565575001350 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 565575001351 Recombination protein O N terminal; Region: RecO_N; pfam11967 565575001352 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 565575001353 Recombination protein O C terminal; Region: RecO_C; pfam02565 565575001354 glycyl-tRNA synthetase; Provisional; Region: PRK04173 565575001355 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 565575001356 active site 565575001357 motif 2; other site 565575001358 motif 3; other site 565575001359 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 565575001360 anticodon binding site; other site 565575001361 DNA primase, catalytic core; Region: dnaG; TIGR01391 565575001362 CHC2 zinc finger; Region: zf-CHC2; cl02597 565575001363 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 565575001364 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 565575001365 active site 565575001366 metal binding site [ion binding]; metal-binding site 565575001367 interdomain interaction site; other site 565575001368 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 565575001369 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 565575001370 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 565575001371 RNA binding surface [nucleotide binding]; other site 565575001372 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 565575001373 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 565575001374 putative active site [active] 565575001375 metal binding site [ion binding]; metal-binding site 565575001376 homodimer binding site [polypeptide binding]; other site 565575001377 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 565575001378 UvrD/REP helicase; Region: UvrD-helicase; cl14126 565575001379 UvrD/REP helicase; Region: UvrD-helicase; cl14126 565575001380 RDD family; Region: RDD; cl00746 565575001381 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 565575001382 active site 565575001383 Phosphopantetheine attachment site; Region: PP-binding; cl09936 565575001384 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 565575001385 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 565575001386 cofactor binding site; other site 565575001387 DNA binding site [nucleotide binding] 565575001388 substrate interaction site [chemical binding]; other site 565575001389 Bsp6I restriction endonuclease; Region: RE_Bsp6I; pfam09504 565575001390 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 565575001391 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 565575001392 interface (dimer of trimers) [polypeptide binding]; other site 565575001393 Substrate-binding/catalytic site; other site 565575001394 Zn-binding sites [ion binding]; other site 565575001395 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 565575001396 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 565575001397 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 565575001398 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 565575001399 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39E; cd02424 565575001400 putative active site [active] 565575001401 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 565575001402 Walker A/P-loop; other site 565575001403 ATP binding site [chemical binding]; other site 565575001404 Q-loop/lid; other site 565575001405 ABC transporter signature motif; other site 565575001406 Walker B; other site 565575001407 D-loop; other site 565575001408 H-loop/switch region; other site 565575001409 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 565575001410 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 565575001411 hinge region; other site 565575001412 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 565575001413 putative nucleotide binding site [chemical binding]; other site 565575001414 uridine monophosphate binding site [chemical binding]; other site 565575001415 homohexameric interface [polypeptide binding]; other site 565575001416 elongation factor Ts; Provisional; Region: tsf; PRK09377 565575001417 Elongation factor TS; Region: EF_TS; pfam00889 565575001418 Elongation factor TS; Region: EF_TS; pfam00889 565575001419 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 565575001420 ABC-ATPase subunit interface; other site 565575001421 dimer interface [polypeptide binding]; other site 565575001422 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 565575001423 ABC-ATPase subunit interface; other site 565575001424 dimer interface [polypeptide binding]; other site 565575001425 putative PBP binding regions; other site 565575001426 Domain of unknown function DUF31; Region: DUF31; pfam01732 565575001427 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 565575001428 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; cl11557 565575001429 DUF1410 domain; Region: DUF1410; pfam07198 565575001430 DUF1410 domain; Region: DUF1410; pfam07198 565575001431 DUF1410 domain; Region: DUF1410; pfam07198 565575001432 oligoendopeptidase F; Region: pepF; TIGR00181 565575001433 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 565575001434 Zn binding site [ion binding]; other site 565575001435 elongation factor Tu; Reviewed; Region: PRK00049 565575001436 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 565575001437 G1 box; other site 565575001438 GEF interaction site [polypeptide binding]; other site 565575001439 GTP/Mg2+ binding site [chemical binding]; other site 565575001440 Switch I region; other site 565575001441 G2 box; other site 565575001442 G3 box; other site 565575001443 Switch II region; other site 565575001444 G4 box; other site 565575001445 G5 box; other site 565575001446 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 565575001447 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 565575001448 Antibiotic Binding Site [chemical binding]; other site 565575001449 elongation factor G; Reviewed; Region: PRK00007 565575001450 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 565575001451 G1 box; other site 565575001452 putative GEF interaction site [polypeptide binding]; other site 565575001453 GTP/Mg2+ binding site [chemical binding]; other site 565575001454 Switch I region; other site 565575001455 G2 box; other site 565575001456 G3 box; other site 565575001457 Switch II region; other site 565575001458 G4 box; other site 565575001459 G5 box; other site 565575001460 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 565575001461 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 565575001462 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 565575001463 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 565575001464 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 565575001465 S17 interaction site [polypeptide binding]; other site 565575001466 S8 interaction site; other site 565575001467 16S rRNA interaction site [nucleotide binding]; other site 565575001468 streptomycin interaction site [chemical binding]; other site 565575001469 23S rRNA interaction site [nucleotide binding]; other site 565575001470 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 565575001471 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 565575001472 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 565575001473 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 565575001474 active site 565575001475 substrate binding site [chemical binding]; other site 565575001476 metal binding site [ion binding]; metal-binding site 565575001477 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 565575001478 active site 565575001479 catalytic motif [active] 565575001480 Zn binding site [ion binding]; other site 565575001481 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 565575001482 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 565575001483 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 565575001484 active site 565575001485 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 565575001486 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 565575001487 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 565575001488 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 565575001489 active site 565575001490 dimer interface [polypeptide binding]; other site 565575001491 motif 1; other site 565575001492 motif 2; other site 565575001493 motif 3; other site 565575001494 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 565575001495 anticodon binding site; other site 565575001496 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 565575001497 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 565575001498 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 565575001499 dimerization interface 3.5A [polypeptide binding]; other site 565575001500 active site 565575001501 Cobalt transport protein; Region: CbiQ; cl00463 565575001502 Cobalt transport protein; Region: CbiQ; cl00463 565575001503 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 565575001504 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 565575001505 Walker A/P-loop; other site 565575001506 ATP binding site [chemical binding]; other site 565575001507 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 565575001508 Q-loop/lid; other site 565575001509 ABC transporter signature motif; other site 565575001510 Walker B; other site 565575001511 D-loop; other site 565575001512 H-loop/switch region; other site 565575001513 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 565575001514 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 565575001515 Walker A/P-loop; other site 565575001516 ATP binding site [chemical binding]; other site 565575001517 Q-loop/lid; other site 565575001518 ABC transporter signature motif; other site 565575001519 Walker B; other site 565575001520 D-loop; other site 565575001521 H-loop/switch region; other site 565575001522 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 565575001523 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 565575001524 mRNA/rRNA interface [nucleotide binding]; other site 565575001525 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 565575001526 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 565575001527 23S rRNA interface [nucleotide binding]; other site 565575001528 L7/L12 interface [polypeptide binding]; other site 565575001529 putative thiostrepton binding site; other site 565575001530 L25 interface [polypeptide binding]; other site 565575001531 FtsX-like permease family; Region: FtsX; pfam02687 565575001532 DUF1410 domain; Region: DUF1410; pfam07198 565575001533 FtsX-like permease family; Region: FtsX; pfam02687 565575001534 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 565575001535 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 565575001536 RecX family; Region: RecX; cl00936 565575001537 GatB domain; Region: GatB_Yqey; cl11497 565575001538 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 565575001539 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 565575001540 hypothetical protein; Provisional; Region: PRK09609 565575001541 hypothetical protein; Provisional; Region: PRK09609 565575001542 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 565575001543 replicative DNA helicase; Region: DnaB; TIGR00665 565575001544 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 565575001545 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 565575001546 Walker A motif; other site 565575001547 ATP binding site [chemical binding]; other site 565575001548 Walker B motif; other site 565575001549 DNA binding loops [nucleotide binding] 565575001550 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 565575001551 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 565575001552 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 565575001553 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 565575001554 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 565575001555 dimer interface [polypeptide binding]; other site 565575001556 ssDNA binding site [nucleotide binding]; other site 565575001557 tetramer (dimer of dimers) interface [polypeptide binding]; other site 565575001558 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 565575001559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 565575001560 Coenzyme A binding pocket [chemical binding]; other site 565575001561 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 565575001562 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 565575001563 catalytic residues [active] 565575001564 catalytic residues [active] 565575001565 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 565575001566 active site 565575001567 catalytic residues [active] 565575001568 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 565575001569 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 565575001570 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 565575001571 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 565575001572 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 565575001573 Walker A/P-loop; other site 565575001574 ATP binding site [chemical binding]; other site 565575001575 Q-loop/lid; other site 565575001576 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 565575001577 ABC transporter signature motif; other site 565575001578 Walker B; other site 565575001579 D-loop; other site 565575001580 H-loop/switch region; other site 565575001581 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 565575001582 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 565575001583 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 565575001584 Walker A/P-loop; other site 565575001585 ATP binding site [chemical binding]; other site 565575001586 Q-loop/lid; other site 565575001587 ABC transporter signature motif; other site 565575001588 Walker B; other site 565575001589 D-loop; other site 565575001590 H-loop/switch region; other site 565575001591 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 565575001592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 565575001593 dimer interface [polypeptide binding]; other site 565575001594 conserved gate region; other site 565575001595 putative PBP binding loops; other site 565575001596 ABC-ATPase subunit interface; other site 565575001597 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 565575001598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 565575001599 dimer interface [polypeptide binding]; other site 565575001600 conserved gate region; other site 565575001601 putative PBP binding loops; other site 565575001602 ABC-ATPase subunit interface; other site 565575001603 Uncharacterized conserved protein [Function unknown]; Region: COG1284 565575001604 Uncharacterized conserved protein [Function unknown]; Region: COG1284 565575001605 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 565575001606 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 565575001607 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 565575001608 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 565575001609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 565575001610 active site 565575001611 motif I; other site 565575001612 motif II; other site 565575001613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 565575001614 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 565575001615 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 565575001616 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 565575001617 DNA helicase, putative; Region: TIGR00376 565575001618 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 565575001619 Ion channel; Region: Ion_trans_2; cl11596 565575001620 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 565575001621 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 565575001622 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 565575001623 23S rRNA interface [nucleotide binding]; other site 565575001624 L3 interface [polypeptide binding]; other site 565575001625 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 565575001626 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 565575001627 NusG family protein; Region: NusG_myco; TIGR01956 565575001628 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 565575001629 putative homodimer interface [polypeptide binding]; other site 565575001630 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 565575001631 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 565575001632 ATP binding site [chemical binding]; other site 565575001633 putative Mg++ binding site [ion binding]; other site 565575001634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 565575001635 nucleotide binding region [chemical binding]; other site 565575001636 ATP-binding site [chemical binding]; other site 565575001637 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565575001638 MatE; Region: MatE; pfam01554 565575001639 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 565575001640 MatE; Region: MatE; pfam01554 565575001641 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 565575001642 intersubunit interface [polypeptide binding]; other site 565575001643 active site 565575001644 catalytic residue [active] 565575001645 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 565575001646 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 565575001647 TPP-binding site [chemical binding]; other site 565575001648 dimer interface [polypeptide binding]; other site 565575001649 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 565575001650 PYR/PP interface [polypeptide binding]; other site 565575001651 dimer interface [polypeptide binding]; other site 565575001652 TPP binding site [chemical binding]; other site 565575001653 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 565575001654 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 565575001655 dimerization domain swap beta strand [polypeptide binding]; other site 565575001656 regulatory protein interface [polypeptide binding]; other site 565575001657 active site 565575001658 regulatory phosphorylation site [posttranslational modification]; other site 565575001659 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 565575001660 putative active site [active] 565575001661 catalytic site [active] 565575001662 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 565575001663 putative active site [active] 565575001664 catalytic site [active] 565575001665 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 565575001666 catalytic residues [active] 565575001667 DNA topoisomerase I; Validated; Region: PRK05582 565575001668 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 565575001669 active site 565575001670 interdomain interaction site; other site 565575001671 putative metal-binding site [ion binding]; other site 565575001672 nucleotide binding site [chemical binding]; other site 565575001673 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 565575001674 domain I; other site 565575001675 DNA binding groove [nucleotide binding] 565575001676 phosphate binding site [ion binding]; other site 565575001677 domain II; other site 565575001678 domain III; other site 565575001679 nucleotide binding site [chemical binding]; other site 565575001680 catalytic site [active] 565575001681 domain IV; other site 565575001682 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 565575001683 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 565575001684 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 565575001685 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 565575001686 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 565575001687 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 565575001688 GTP/Mg2+ binding site [chemical binding]; other site 565575001689 G4 box; other site 565575001690 G5 box; other site 565575001691 G1 box; other site 565575001692 Switch I region; other site 565575001693 G2 box; other site 565575001694 G3 box; other site 565575001695 Switch II region; other site 565575001696 Thymidine kinase; Region: TK; cl00631 565575001697 GTP-binding protein YchF; Reviewed; Region: PRK09601 565575001698 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 565575001699 G1 box; other site 565575001700 GTP/Mg2+ binding site [chemical binding]; other site 565575001701 Switch I region; other site 565575001702 G2 box; other site 565575001703 Switch II region; other site 565575001704 G3 box; other site 565575001705 G4 box; other site 565575001706 G5 box; other site 565575001707 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 565575001708 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 565575001709 hypothetical protein; Provisional; Region: PRK08185 565575001710 intersubunit interface [polypeptide binding]; other site 565575001711 active site 565575001712 zinc binding site [ion binding]; other site 565575001713 Na+ binding site [ion binding]; other site 565575001714 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 565575001715 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 565575001716 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 565575001717 Zn2+ binding site [ion binding]; other site 565575001718 Mg2+ binding site [ion binding]; other site 565575001719 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 565575001720 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 565575001721 HIGH motif; other site 565575001722 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 565575001723 active site 565575001724 KMSKS motif; other site 565575001725 hypothetical protein; Provisional; Region: PRK05905 565575001726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 565575001727 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 565575001728 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 565575001729 Ribonuclease P; Region: Ribonuclease_P; cl00457 565575001730 Ribosomal protein L34; Region: Ribosomal_L34; cl00370