-- dump date 20111121_015540 -- class Genbank::misc_feature -- table misc_feature_note -- id note 391735000001 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735000002 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 391735000003 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 391735000004 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735000005 Walker A motif; other site 391735000006 ATP binding site [chemical binding]; other site 391735000007 Walker B motif; other site 391735000008 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 391735000009 putative active site [active] 391735000010 catalytic site [active] 391735000011 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 391735000012 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735000013 Walker A motif; other site 391735000014 ATP binding site [chemical binding]; other site 391735000015 Walker B motif; other site 391735000016 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 391735000017 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 391735000018 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 391735000019 VirB7 interaction site; other site 391735000020 VirB8 protein; Region: VirB8; cl01500 391735000021 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 391735000022 Type IV secretion system proteins; Region: T4SS; cl06849 391735000023 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 391735000024 VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 391735000025 TrbC/VIRB2 family; Region: TrbC; cl01583 391735000026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 391735000027 Protein of unknown function (DUF497); Region: DUF497; cl01108 391735000028 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 391735000029 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391735000030 multiple promoter invertase; Provisional; Region: mpi; PRK13413 391735000031 catalytic residues [active] 391735000032 catalytic nucleophile [active] 391735000033 Presynaptic Site I dimer interface [polypeptide binding]; other site 391735000034 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391735000035 Synaptic Flat tetramer interface [polypeptide binding]; other site 391735000036 Synaptic Site I dimer interface [polypeptide binding]; other site 391735000037 DNA binding site [nucleotide binding] 391735000038 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391735000039 DNA-binding interface [nucleotide binding]; DNA binding site 391735000040 Replication initiator protein A; Region: RPA; cl02339 391735000041 Protein of unknown function (DUF497); Region: DUF497; cl01108 391735000042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 391735000043 Replication initiator protein A; Region: RPA; cl02339 391735000044 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 391735000045 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 391735000046 hypothetical protein; Validated; Region: PRK06672 391735000047 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 391735000048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735000049 Walker A motif; other site 391735000050 ATP binding site [chemical binding]; other site 391735000051 Walker B motif; other site 391735000052 arginine finger; other site 391735000053 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 391735000054 DnaA box-binding interface [nucleotide binding]; other site 391735000055 DNA polymerase III subunit beta; Validated; Region: PRK05643 391735000056 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 391735000057 putative DNA binding surface [nucleotide binding]; other site 391735000058 dimer interface [polypeptide binding]; other site 391735000059 beta-clamp/clamp loader binding surface; other site 391735000060 beta-clamp/translesion DNA polymerase binding surface; other site 391735000061 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 391735000062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735000063 ATP binding site [chemical binding]; other site 391735000064 Mg2+ binding site [ion binding]; other site 391735000065 G-X-G motif; other site 391735000066 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 391735000067 anchoring element; other site 391735000068 dimer interface [polypeptide binding]; other site 391735000069 ATP binding site [chemical binding]; other site 391735000070 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 391735000071 active site 391735000072 putative metal-binding site [ion binding]; other site 391735000073 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 391735000074 Fic/DOC family; Region: Fic; cl00960 391735000075 mobile mystery protein A; Region: mob_myst_A; TIGR02612 391735000076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391735000077 non-specific DNA binding site [nucleotide binding]; other site 391735000078 salt bridge; other site 391735000079 sequence-specific DNA binding site [nucleotide binding]; other site 391735000080 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 391735000081 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735000082 ATP binding site [chemical binding]; other site 391735000083 putative Mg++ binding site [ion binding]; other site 391735000084 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 391735000085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735000086 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391735000087 dimerization interface [polypeptide binding]; other site 391735000088 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977 391735000089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735000090 putative substrate translocation pore; other site 391735000091 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 391735000092 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 391735000093 substrate binding site [chemical binding]; other site 391735000094 active site 391735000095 primosome assembly protein PriA; Validated; Region: PRK05580 391735000096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735000097 ATP binding site [chemical binding]; other site 391735000098 putative Mg++ binding site [ion binding]; other site 391735000099 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 391735000100 shikimate kinase; Reviewed; Region: aroK; PRK00131 391735000101 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 391735000102 ADP binding site [chemical binding]; other site 391735000103 magnesium binding site [ion binding]; other site 391735000104 putative shikimate binding site; other site 391735000105 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 391735000106 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 391735000107 substrate binding pocket [chemical binding]; other site 391735000108 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 391735000109 B12 binding site [chemical binding]; other site 391735000110 cobalt ligand [ion binding]; other site 391735000111 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 391735000112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391735000113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735000114 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 391735000115 active site 391735000116 dimer interface [polypeptide binding]; other site 391735000117 metal binding site [ion binding]; metal-binding site 391735000118 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 391735000119 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 391735000120 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 391735000121 Pilus assembly protein, PilP; Region: PilP; cl01235 391735000122 Pilus assembly protein, PilO; Region: PilO; cl01234 391735000123 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 391735000124 Competence protein A; Region: Competence_A; pfam11104 391735000125 GspL cytoplasmic actin-ATPase-like region; Region: GspL; pfam05134 391735000126 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 391735000127 Transglycosylase; Region: Transgly; cl07896 391735000128 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 391735000129 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cl00238 391735000130 putative iron binding site [ion binding]; other site 391735000131 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 391735000132 FAD binding domain; Region: FAD_binding_4; pfam01565 391735000133 Quinolinate synthetase A protein; Region: NadA; cl00420 391735000134 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 391735000135 oligomerization interface [polypeptide binding]; other site 391735000136 active site 391735000137 metal binding site [ion binding]; metal-binding site 391735000138 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391735000139 pantoate--beta-alanine ligase; Region: panC; TIGR00018 391735000140 active site 391735000141 nucleotide binding site [chemical binding]; other site 391735000142 HIGH motif; other site 391735000143 KMSKS motif; other site 391735000144 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; cl09206 391735000145 CHASE3 domain; Region: CHASE3; cl05000 391735000146 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391735000147 Histidine kinase; Region: HisKA_3; pfam07730 391735000148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735000149 ATP binding site [chemical binding]; other site 391735000150 Mg2+ binding site [ion binding]; other site 391735000151 G-X-G motif; other site 391735000152 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391735000153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735000154 active site 391735000155 phosphorylation site [posttranslational modification] 391735000156 intermolecular recognition site; other site 391735000157 dimerization interface [polypeptide binding]; other site 391735000158 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 391735000159 DNA binding residues [nucleotide binding] 391735000160 dimerization interface [polypeptide binding]; other site 391735000161 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391735000162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735000163 active site 391735000164 phosphorylation site [posttranslational modification] 391735000165 intermolecular recognition site; other site 391735000166 dimerization interface [polypeptide binding]; other site 391735000167 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 391735000168 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 391735000169 ATP binding site [chemical binding]; other site 391735000170 substrate interface [chemical binding]; other site 391735000171 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 391735000172 C-terminal peptidase (prc); Region: prc; TIGR00225 391735000173 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 391735000174 protein binding site [polypeptide binding]; other site 391735000175 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 391735000176 Catalytic dyad [active] 391735000177 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391735000178 catalytic core [active] 391735000179 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391735000180 Dehydratase family; Region: ILVD_EDD; cl00340 391735000181 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 391735000182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735000183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000184 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391735000185 active site residue [active] 391735000186 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 391735000187 GSH binding site [chemical binding]; other site 391735000188 catalytic residues [active] 391735000189 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 391735000190 SecA binding site; other site 391735000191 Preprotein binding site; other site 391735000192 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 391735000193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735000194 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 391735000195 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391735000196 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391735000197 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735000198 DNA-binding site [nucleotide binding]; DNA binding site 391735000199 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391735000200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735000201 homodimer interface [polypeptide binding]; other site 391735000202 catalytic residue [active] 391735000203 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391735000204 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 391735000205 putative ligand binding site [chemical binding]; other site 391735000206 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735000207 TM-ABC transporter signature motif; other site 391735000208 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 391735000209 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735000210 Walker A/P-loop; other site 391735000211 ATP binding site [chemical binding]; other site 391735000212 Q-loop/lid; other site 391735000213 ABC transporter signature motif; other site 391735000214 Walker B; other site 391735000215 D-loop; other site 391735000216 H-loop/switch region; other site 391735000217 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 391735000218 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391735000219 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 391735000220 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391735000221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735000222 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 391735000223 EamA-like transporter family; Region: EamA; cl01037 391735000224 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391735000225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735000226 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 391735000227 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391735000228 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 391735000229 putative ligand binding site [chemical binding]; other site 391735000230 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735000231 TM-ABC transporter signature motif; other site 391735000232 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391735000233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735000234 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 391735000235 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 391735000236 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735000237 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735000238 Walker A/P-loop; other site 391735000239 ATP binding site [chemical binding]; other site 391735000240 Q-loop/lid; other site 391735000241 ABC transporter signature motif; other site 391735000242 Walker B; other site 391735000243 D-loop; other site 391735000244 H-loop/switch region; other site 391735000245 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735000246 TM-ABC transporter signature motif; other site 391735000247 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 391735000248 putative ligand binding site [chemical binding]; other site 391735000249 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735000250 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735000251 Walker A/P-loop; other site 391735000252 ATP binding site [chemical binding]; other site 391735000253 Q-loop/lid; other site 391735000254 ABC transporter signature motif; other site 391735000255 Walker B; other site 391735000256 D-loop; other site 391735000257 H-loop/switch region; other site 391735000258 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735000259 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000260 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 391735000261 putative ligand binding site [chemical binding]; other site 391735000262 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 391735000263 putative ligand binding site [chemical binding]; other site 391735000264 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391735000265 substrate binding site [chemical binding]; other site 391735000266 ATP binding site [chemical binding]; other site 391735000267 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 391735000268 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 391735000269 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391735000270 PYR/PP interface [polypeptide binding]; other site 391735000271 dimer interface [polypeptide binding]; other site 391735000272 TPP binding site [chemical binding]; other site 391735000273 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391735000274 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 391735000275 TPP-binding site [chemical binding]; other site 391735000276 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391735000277 KduI/IolB family; Region: KduI; cl01508 391735000278 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 391735000279 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 391735000280 active site lid residues [active] 391735000281 substrate binding pocket [chemical binding]; other site 391735000282 catalytic residues [active] 391735000283 substrate-Mg2+ binding site; other site 391735000284 aspartate-rich region 1; other site 391735000285 aspartate-rich region 2; other site 391735000286 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735000287 FtsH protease regulator HflC; Provisional; Region: PRK11029 391735000288 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 391735000289 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 391735000290 HflK protein; Region: hflK; TIGR01933 391735000291 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 391735000292 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 391735000293 G1 box; other site 391735000294 GTP/Mg2+ binding site [chemical binding]; other site 391735000295 Switch I region; other site 391735000296 G2 box; other site 391735000297 G3 box; other site 391735000298 Switch II region; other site 391735000299 G4 box; other site 391735000300 G5 box; other site 391735000301 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 391735000302 Sm1 motif; other site 391735000303 D3 - B interaction site; other site 391735000304 D1 - D2 interaction site; other site 391735000305 Hfq - Hfq interaction site; other site 391735000306 RNA binding pocket [nucleotide binding]; other site 391735000307 Sm2 motif; other site 391735000308 GTP-binding protein Der; Reviewed; Region: PRK00093 391735000309 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 391735000310 G1 box; other site 391735000311 GTP/Mg2+ binding site [chemical binding]; other site 391735000312 Switch I region; other site 391735000313 G2 box; other site 391735000314 Switch II region; other site 391735000315 G3 box; other site 391735000316 G4 box; other site 391735000317 G5 box; other site 391735000318 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 391735000319 G1 box; other site 391735000320 GTP/Mg2+ binding site [chemical binding]; other site 391735000321 Switch I region; other site 391735000322 G2 box; other site 391735000323 G3 box; other site 391735000324 Switch II region; other site 391735000325 G4 box; other site 391735000326 G5 box; other site 391735000327 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 391735000328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 391735000329 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 391735000330 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 391735000331 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 391735000332 dimer interface [polypeptide binding]; other site 391735000333 motif 1; other site 391735000334 active site 391735000335 motif 2; other site 391735000336 motif 3; other site 391735000337 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 391735000338 anticodon binding site; other site 391735000339 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 391735000340 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 391735000341 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 391735000342 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 391735000343 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 391735000344 TPR motif; other site 391735000345 binding surface 391735000346 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 391735000347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 391735000348 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 391735000349 active site 391735000350 multimer interface [polypeptide binding]; other site 391735000351 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 391735000352 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391735000353 RNA binding surface [nucleotide binding]; other site 391735000354 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 391735000355 active site 391735000356 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 391735000357 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 391735000358 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391735000359 RNA binding surface [nucleotide binding]; other site 391735000360 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 391735000361 active site 391735000362 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 391735000363 Peptidase family M23; Region: Peptidase_M23; pfam01551 391735000364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735000365 Survival protein SurE; Region: SurE; cl00448 391735000366 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 391735000367 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391735000368 NAD(P) binding site [chemical binding]; other site 391735000369 PhoD-like phosphatase; Region: PhoD; pfam09423 391735000370 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 391735000371 DNA primase, catalytic core; Region: dnaG; TIGR01391 391735000372 CHC2 zinc finger; Region: zf-CHC2; cl02597 391735000373 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 391735000374 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 391735000375 active site 391735000376 metal binding site [ion binding]; metal-binding site 391735000377 interdomain interaction site; other site 391735000378 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 391735000379 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391735000380 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 391735000381 replication factor C small subunit; Reviewed; Region: rfc; PRK00440 391735000382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735000383 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391735000384 Walker A motif; other site 391735000385 ATP binding site [chemical binding]; other site 391735000386 Walker B motif; other site 391735000387 arginine finger; other site 391735000388 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 391735000389 active site 391735000390 catalytic triad [active] 391735000391 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 391735000392 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 391735000393 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 391735000394 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 391735000395 Divergent AAA domain; Region: AAA_4; pfam04326 391735000396 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 391735000397 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735000398 ATP binding site [chemical binding]; other site 391735000399 putative Mg++ binding site [ion binding]; other site 391735000400 Transposase domain (DUF772); Region: DUF772; cl12084 391735000401 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391735000402 nucleotide binding region [chemical binding]; other site 391735000403 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 391735000404 ATP-binding site [chemical binding]; other site 391735000405 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735000406 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391735000407 NAD(P) binding site [chemical binding]; other site 391735000408 catalytic residues [active] 391735000409 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 391735000410 Peptidase C26; Region: Peptidase_C26; pfam07722 391735000411 catalytic triad [active] 391735000412 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 391735000413 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 391735000414 putative active site [active] 391735000415 metal binding site [ion binding]; metal-binding site 391735000416 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391735000417 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391735000418 Uncharacterized conserved protein [Function unknown]; Region: COG2128 391735000419 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391735000420 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 391735000421 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735000422 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735000423 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735000424 Walker A/P-loop; other site 391735000425 ATP binding site [chemical binding]; other site 391735000426 Q-loop/lid; other site 391735000427 ABC transporter signature motif; other site 391735000428 Walker B; other site 391735000429 D-loop; other site 391735000430 H-loop/switch region; other site 391735000431 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735000432 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735000433 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735000434 Walker A/P-loop; other site 391735000435 ATP binding site [chemical binding]; other site 391735000436 Q-loop/lid; other site 391735000437 ABC transporter signature motif; other site 391735000438 Walker B; other site 391735000439 D-loop; other site 391735000440 H-loop/switch region; other site 391735000441 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735000442 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391735000443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735000444 dimer interface [polypeptide binding]; other site 391735000445 conserved gate region; other site 391735000446 putative PBP binding loops; other site 391735000447 ABC-ATPase subunit interface; other site 391735000448 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735000449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735000450 dimer interface [polypeptide binding]; other site 391735000451 conserved gate region; other site 391735000452 putative PBP binding loops; other site 391735000453 ABC-ATPase subunit interface; other site 391735000454 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 391735000455 classical (c) SDRs; Region: SDR_c; cd05233 391735000456 NAD(P) binding site [chemical binding]; other site 391735000457 active site 391735000458 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391735000459 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391735000460 DNA binding site [nucleotide binding] 391735000461 domain linker motif; other site 391735000462 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_5; cd06281 391735000463 putative dimerization interface [polypeptide binding]; other site 391735000464 putative ligand binding site [chemical binding]; other site 391735000465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735000466 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000467 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735000468 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 391735000469 Integrase core domain; Region: rve; cl01316 391735000470 Protein of unknown function, DUF488; Region: DUF488; cl01246 391735000471 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735000472 RHS protein; Region: RHS; pfam03527 391735000473 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 391735000474 hypothetical protein; Provisional; Region: PRK13795 391735000475 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735000476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735000477 dimer interface [polypeptide binding]; other site 391735000478 conserved gate region; other site 391735000479 putative PBP binding loops; other site 391735000480 ABC-ATPase subunit interface; other site 391735000481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735000482 dimer interface [polypeptide binding]; other site 391735000483 conserved gate region; other site 391735000484 putative PBP binding loops; other site 391735000485 ABC-ATPase subunit interface; other site 391735000486 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735000487 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735000488 Walker A/P-loop; other site 391735000489 ATP binding site [chemical binding]; other site 391735000490 Q-loop/lid; other site 391735000491 ABC transporter signature motif; other site 391735000492 Walker B; other site 391735000493 D-loop; other site 391735000494 H-loop/switch region; other site 391735000495 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735000496 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 391735000497 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735000498 Walker A/P-loop; other site 391735000499 ATP binding site [chemical binding]; other site 391735000500 Q-loop/lid; other site 391735000501 ABC transporter signature motif; other site 391735000502 Walker B; other site 391735000503 D-loop; other site 391735000504 H-loop/switch region; other site 391735000505 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735000506 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 391735000507 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735000508 amidase; Provisional; Region: PRK07042 391735000509 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 391735000510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735000511 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735000513 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000514 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 391735000515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 391735000516 S-adenosylmethionine binding site [chemical binding]; other site 391735000517 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735000518 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 391735000519 Predicted membrane protein [Function unknown]; Region: COG2119 391735000520 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 391735000521 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 391735000522 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 391735000523 RNA/DNA binding site [nucleotide binding]; other site 391735000524 RRM dimerization site [polypeptide binding]; other site 391735000525 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 391735000526 RNA/DNA binding site [nucleotide binding]; other site 391735000527 RRM dimerization site [polypeptide binding]; other site 391735000528 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 391735000529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735000530 NAD(P) binding site [chemical binding]; other site 391735000531 active site 391735000532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 391735000533 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 391735000534 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 391735000535 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 391735000536 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 391735000537 putative active site [active] 391735000538 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 391735000539 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 391735000540 putative cation:proton antiport protein; Provisional; Region: PRK10669 391735000541 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 391735000542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735000543 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 391735000544 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 391735000545 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 391735000546 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 391735000547 DsbD alpha interface [polypeptide binding]; other site 391735000548 catalytic residues [active] 391735000549 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 391735000550 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391735000551 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735000552 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391735000553 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735000554 TM-ABC transporter signature motif; other site 391735000555 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735000556 TM-ABC transporter signature motif; other site 391735000557 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735000558 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735000559 Walker A/P-loop; other site 391735000560 ATP binding site [chemical binding]; other site 391735000561 Q-loop/lid; other site 391735000562 ABC transporter signature motif; other site 391735000563 Walker B; other site 391735000564 D-loop; other site 391735000565 H-loop/switch region; other site 391735000566 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735000567 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735000568 Walker A/P-loop; other site 391735000569 ATP binding site [chemical binding]; other site 391735000570 Q-loop/lid; other site 391735000571 ABC transporter signature motif; other site 391735000572 Walker B; other site 391735000573 D-loop; other site 391735000574 H-loop/switch region; other site 391735000575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735000576 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000577 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735000578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735000579 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 391735000580 putative dimerization interface [polypeptide binding]; other site 391735000581 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000582 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735000583 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 391735000584 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 391735000585 active site 391735000586 protocatechuate 4,5-dioxygenase; Provisional; Region: pcmA; PRK13372 391735000587 The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924 391735000588 tetramer interface [polypeptide binding]; other site 391735000589 dimer interface [polypeptide binding]; other site 391735000590 active site 391735000591 Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364 391735000592 active site 391735000593 Fe(II) binding site [ion binding]; other site 391735000594 dimer interface [polypeptide binding]; other site 391735000595 tetramer interface [polypeptide binding]; other site 391735000596 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391735000597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735000598 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391735000599 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391735000600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735000601 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391735000602 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 391735000603 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 391735000604 putative active site [active] 391735000605 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 391735000606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735000607 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_5; cd08426 391735000608 putative dimerization interface [polypeptide binding]; other site 391735000609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735000610 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000611 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735000612 DNA-binding site [nucleotide binding]; DNA binding site 391735000613 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735000614 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 391735000615 NAD(P) binding site [chemical binding]; other site 391735000616 catalytic residues [active] 391735000617 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391735000618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735000619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735000620 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000621 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735000622 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391735000623 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391735000624 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 391735000625 Walker A/P-loop; other site 391735000626 ATP binding site [chemical binding]; other site 391735000627 Q-loop/lid; other site 391735000628 ABC transporter signature motif; other site 391735000629 Walker B; other site 391735000630 D-loop; other site 391735000631 H-loop/switch region; other site 391735000632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735000633 dimer interface [polypeptide binding]; other site 391735000634 conserved gate region; other site 391735000635 putative PBP binding loops; other site 391735000636 ABC-ATPase subunit interface; other site 391735000637 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391735000638 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735000639 substrate binding pocket [chemical binding]; other site 391735000640 membrane-bound complex binding site; other site 391735000641 hinge residues; other site 391735000642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391735000643 non-specific DNA binding site [nucleotide binding]; other site 391735000644 salt bridge; other site 391735000645 sequence-specific DNA binding site [nucleotide binding]; other site 391735000646 Cupin domain; Region: Cupin_2; cl09118 391735000647 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 391735000648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735000649 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 391735000650 transketolase; Reviewed; Region: PRK12753 391735000651 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 391735000652 TPP-binding site [chemical binding]; other site 391735000653 dimer interface [polypeptide binding]; other site 391735000654 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391735000655 PYR/PP interface [polypeptide binding]; other site 391735000656 dimer interface [polypeptide binding]; other site 391735000657 TPP binding site [chemical binding]; other site 391735000658 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391735000659 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 391735000660 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 391735000661 Substrate binding site [chemical binding]; other site 391735000662 metal binding site [ion binding]; metal-binding site 391735000663 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 391735000664 proline aminopeptidase P II; Provisional; Region: PRK10879 391735000665 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 391735000666 active site 391735000667 pyruvate kinase; Provisional; Region: PRK05826 391735000668 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 391735000669 domain interfaces; other site 391735000670 active site 391735000671 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 391735000672 active site 391735000673 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 391735000674 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735000675 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 391735000676 putative dimerization interface [polypeptide binding]; other site 391735000677 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000678 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391735000679 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735000680 Walker A/P-loop; other site 391735000681 ATP binding site [chemical binding]; other site 391735000682 Q-loop/lid; other site 391735000683 ABC transporter signature motif; other site 391735000684 Walker B; other site 391735000685 D-loop; other site 391735000686 H-loop/switch region; other site 391735000687 TOBE domain; Region: TOBE_2; cl01440 391735000688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735000689 dimer interface [polypeptide binding]; other site 391735000690 conserved gate region; other site 391735000691 ABC-ATPase subunit interface; other site 391735000692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735000693 dimer interface [polypeptide binding]; other site 391735000694 conserved gate region; other site 391735000695 putative PBP binding loops; other site 391735000696 ABC-ATPase subunit interface; other site 391735000697 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391735000698 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391735000699 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735000700 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391735000701 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 391735000702 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391735000703 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735000704 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 391735000705 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 391735000706 NAD binding site [chemical binding]; other site 391735000707 dimerization interface [polypeptide binding]; other site 391735000708 product binding site; other site 391735000709 substrate binding site [chemical binding]; other site 391735000710 zinc binding site [ion binding]; other site 391735000711 catalytic residues [active] 391735000712 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 391735000713 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 391735000714 active site 391735000715 substrate binding site [chemical binding]; other site 391735000716 metal binding site [ion binding]; metal-binding site 391735000717 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 391735000718 dihydropteroate synthase; Region: DHPS; TIGR01496 391735000719 substrate binding pocket [chemical binding]; other site 391735000720 dimer interface [polypeptide binding]; other site 391735000721 inhibitor binding site; inhibition site 391735000722 FtsH Extracellular; Region: FtsH_ext; pfam06480 391735000723 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 391735000724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735000725 Walker A motif; other site 391735000726 ATP binding site [chemical binding]; other site 391735000727 Walker B motif; other site 391735000728 arginine finger; other site 391735000729 Peptidase family M41; Region: Peptidase_M41; pfam01434 391735000730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735000731 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 391735000732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735000733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735000734 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000735 dimerization interface [polypeptide binding]; other site 391735000736 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 391735000737 eyelet of channel; other site 391735000738 trimer interface [polypeptide binding]; other site 391735000739 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000740 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735000741 Beta-lactamase; Region: Beta-lactamase; cl01009 391735000742 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 391735000743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735000744 Walker A motif; other site 391735000745 ATP binding site [chemical binding]; other site 391735000746 Walker B motif; other site 391735000747 arginine finger; other site 391735000748 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 391735000749 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735000750 naphthoate synthase (dihydroxynaphthoic acid synthetase); Region: menB; TIGR01929 391735000751 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735000752 substrate binding site [chemical binding]; other site 391735000753 oxyanion hole (OAH) forming residues; other site 391735000754 trimer interface [polypeptide binding]; other site 391735000755 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391735000756 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735000757 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 391735000758 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735000759 substrate binding site [chemical binding]; other site 391735000760 oxyanion hole (OAH) forming residues; other site 391735000761 trimer interface [polypeptide binding]; other site 391735000762 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735000763 classical (c) SDRs; Region: SDR_c; cd05233 391735000764 NAD(P) binding site [chemical binding]; other site 391735000765 active site 391735000766 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735000767 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735000768 active site 391735000769 enoyl-CoA hydratase; Provisional; Region: PRK06688 391735000770 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735000771 substrate binding site [chemical binding]; other site 391735000772 oxyanion hole (OAH) forming residues; other site 391735000773 trimer interface [polypeptide binding]; other site 391735000774 short chain dehydrogenase; Provisional; Region: PRK07576 391735000775 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 391735000776 NAD(P) binding site [chemical binding]; other site 391735000777 substrate binding site [chemical binding]; other site 391735000778 homotetramer interface [polypeptide binding]; other site 391735000779 active site 391735000780 homodimer interface [polypeptide binding]; other site 391735000781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735000782 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735000784 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000785 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391735000786 active site 2 [active] 391735000787 active site 1 [active] 391735000788 thiolase; Provisional; Region: PRK06158 391735000789 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 391735000790 active site 391735000791 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735000792 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735000793 active site 391735000794 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 391735000795 DUF35 OB-fold domain; Region: DUF35; pfam01796 391735000796 enoyl-CoA hydratase; Provisional; Region: PRK06688 391735000797 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735000798 substrate binding site [chemical binding]; other site 391735000799 oxyanion hole (OAH) forming residues; other site 391735000800 trimer interface [polypeptide binding]; other site 391735000801 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735000802 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735000803 SAF domain; Region: SAF; cl00555 391735000804 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 391735000805 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 391735000806 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 391735000807 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 391735000808 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 391735000809 ATP binding site [chemical binding]; other site 391735000810 Walker A motif; other site 391735000811 hexamer interface [polypeptide binding]; other site 391735000812 Walker B motif; other site 391735000813 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 391735000814 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 391735000815 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 391735000816 TadE-like protein; Region: TadE; pfam07811 391735000817 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 391735000818 protein-splicing catalytic site; other site 391735000819 thioester formation/cholesterol transfer; other site 391735000820 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 391735000821 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 391735000822 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 391735000823 protein-splicing catalytic site; other site 391735000824 thioester formation/cholesterol transfer; other site 391735000825 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 391735000826 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 391735000827 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 391735000828 protein-splicing catalytic site; other site 391735000829 thioester formation/cholesterol transfer; other site 391735000830 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 391735000831 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 391735000832 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 391735000833 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 391735000834 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 391735000835 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 391735000836 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735000837 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 391735000838 Isochorismatase family; Region: Isochorismatase; pfam00857 391735000839 catalytic triad [active] 391735000840 conserved cis-peptide bond; other site 391735000841 hypothetical protein; Provisional; Region: PRK05939 391735000842 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735000843 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735000844 catalytic residue [active] 391735000845 exonuclease I; Provisional; Region: sbcB; PRK11779 391735000846 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 391735000847 active site 391735000848 substrate binding site [chemical binding]; other site 391735000849 catalytic site [active] 391735000850 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 391735000851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735000852 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000853 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 391735000854 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 391735000855 metal binding site [ion binding]; metal-binding site 391735000856 putative dimer interface [polypeptide binding]; other site 391735000857 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 391735000858 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 391735000859 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391735000860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735000861 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 391735000862 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 391735000863 FMN binding site [chemical binding]; other site 391735000864 active site 391735000865 catalytic residues [active] 391735000866 substrate binding site [chemical binding]; other site 391735000867 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 391735000868 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 391735000869 ferredoxin; Provisional; Region: PRK06991 391735000870 aspartate aminotransferase; Provisional; Region: PRK07681 391735000871 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391735000872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735000873 homodimer interface [polypeptide binding]; other site 391735000874 catalytic residue [active] 391735000875 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 391735000876 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA...; Region: LbH_THP_succinylT; cd03350 391735000877 active site 391735000878 substrate binding site [chemical binding]; other site 391735000879 trimer interface [polypeptide binding]; other site 391735000880 CoA binding site [chemical binding]; other site 391735000881 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 391735000882 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735000883 ATP binding site [chemical binding]; other site 391735000884 Walker B motif; other site 391735000885 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 391735000886 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 391735000887 metal binding site [ion binding]; metal-binding site 391735000888 dimer interface [polypeptide binding]; other site 391735000889 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 391735000890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 391735000891 S-adenosylmethionine binding site [chemical binding]; other site 391735000892 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 391735000893 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735000894 Walker A/P-loop; other site 391735000895 ATP binding site [chemical binding]; other site 391735000896 Q-loop/lid; other site 391735000897 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 391735000898 ABC transporter signature motif; other site 391735000899 Walker B; other site 391735000900 D-loop; other site 391735000901 ABC transporter; Region: ABC_tran_2; pfam12848 391735000902 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 391735000903 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 391735000904 Transposase domain (DUF772); Region: DUF772; cl12084 391735000905 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735000906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735000907 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735000908 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735000909 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 391735000910 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 391735000911 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 391735000912 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 391735000913 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735000914 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 391735000915 putative dimerization interface [polypeptide binding]; other site 391735000916 choline dehydrogenase; Validated; Region: PRK02106 391735000917 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391735000918 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735000919 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735000920 Walker A/P-loop; other site 391735000921 ATP binding site [chemical binding]; other site 391735000922 Q-loop/lid; other site 391735000923 ABC transporter signature motif; other site 391735000924 Walker B; other site 391735000925 D-loop; other site 391735000926 H-loop/switch region; other site 391735000927 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735000928 TM-ABC transporter signature motif; other site 391735000929 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735000930 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735000931 Walker A/P-loop; other site 391735000932 ATP binding site [chemical binding]; other site 391735000933 Q-loop/lid; other site 391735000934 ABC transporter signature motif; other site 391735000935 Walker B; other site 391735000936 D-loop; other site 391735000937 H-loop/switch region; other site 391735000938 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735000939 TM-ABC transporter signature motif; other site 391735000940 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735000941 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 391735000942 putative ligand binding site [chemical binding]; other site 391735000943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735000944 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735000945 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735000946 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 391735000947 active site 391735000948 catalytic residues [active] 391735000949 metal binding site [ion binding]; metal-binding site 391735000950 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735000951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735000952 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 391735000953 dimer interface [polypeptide binding]; other site 391735000954 ssDNA binding site [nucleotide binding]; other site 391735000955 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391735000956 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 391735000957 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 391735000958 Ligand Binding Site [chemical binding]; other site 391735000959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735000960 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 391735000961 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 391735000962 putative dimerization interface [polypeptide binding]; other site 391735000963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 391735000964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735000965 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735000966 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 391735000967 trimer interface [polypeptide binding]; other site 391735000968 eyelet of channel; other site 391735000969 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 391735000970 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391735000971 dimer interface [polypeptide binding]; other site 391735000972 active site 391735000973 threonine dehydratase; Reviewed; Region: PRK09224 391735000974 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391735000975 tetramer interface [polypeptide binding]; other site 391735000976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735000977 catalytic residue [active] 391735000978 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 391735000979 putative Ile/Val binding site [chemical binding]; other site 391735000980 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 391735000981 putative Ile/Val binding site [chemical binding]; other site 391735000982 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 391735000983 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 391735000984 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 391735000985 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735000986 Walker A/P-loop; other site 391735000987 ATP binding site [chemical binding]; other site 391735000988 Q-loop/lid; other site 391735000989 ABC transporter signature motif; other site 391735000990 Walker B; other site 391735000991 D-loop; other site 391735000992 H-loop/switch region; other site 391735000993 excinuclease ABC, A subunit; Region: uvra; TIGR00630 391735000994 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735000995 Walker A/P-loop; other site 391735000996 ATP binding site [chemical binding]; other site 391735000997 Q-loop/lid; other site 391735000998 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 391735000999 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 391735001000 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 391735001001 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 391735001002 Strictosidine synthase; Region: Str_synth; pfam03088 391735001003 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 391735001004 classical (c) SDRs; Region: SDR_c; cd05233 391735001005 NAD(P) binding site [chemical binding]; other site 391735001006 active site 391735001007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391735001008 Coenzyme A binding pocket [chemical binding]; other site 391735001009 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 391735001010 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391735001011 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 391735001012 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 391735001013 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 391735001014 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 391735001015 classical (c) SDRs; Region: SDR_c; cd05233 391735001016 NAD(P) binding site [chemical binding]; other site 391735001017 active site 391735001018 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735001019 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735001020 Walker A/P-loop; other site 391735001021 ATP binding site [chemical binding]; other site 391735001022 Q-loop/lid; other site 391735001023 ABC transporter signature motif; other site 391735001024 Walker B; other site 391735001025 D-loop; other site 391735001026 H-loop/switch region; other site 391735001027 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735001028 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735001029 Walker A/P-loop; other site 391735001030 ATP binding site [chemical binding]; other site 391735001031 Q-loop/lid; other site 391735001032 ABC transporter signature motif; other site 391735001033 Walker B; other site 391735001034 D-loop; other site 391735001035 H-loop/switch region; other site 391735001036 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735001037 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391735001038 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 391735001039 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735001040 Bacterial transcriptional regulator; Region: IclR; pfam01614 391735001041 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 391735001042 putative active site [active] 391735001043 putative CoA binding site [chemical binding]; other site 391735001044 nudix motif; other site 391735001045 metal binding site [ion binding]; metal-binding site 391735001046 CobD/Cbib protein; Region: CobD_Cbib; cl00561 391735001047 GTPase RsgA; Reviewed; Region: PRK00098 391735001048 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 391735001049 GTPase/OB domain interface [polypeptide binding]; other site 391735001050 GTPase/Zn-binding domain interface [polypeptide binding]; other site 391735001051 GTP/Mg2+ binding site [chemical binding]; other site 391735001052 G4 box; other site 391735001053 G5 box; other site 391735001054 G1 box; other site 391735001055 Switch I region; other site 391735001056 G2 box; other site 391735001057 G3 box; other site 391735001058 Switch II region; other site 391735001059 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 391735001060 aromatic arch; other site 391735001061 DCoH dimer interaction site [polypeptide binding]; other site 391735001062 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 391735001063 DCoH tetramer interaction site [polypeptide binding]; other site 391735001064 substrate binding site [chemical binding]; other site 391735001065 Peptidase family M48; Region: Peptidase_M48; cl12018 391735001066 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 391735001067 putative active site [active] 391735001068 putative substrate binding site [chemical binding]; other site 391735001069 catalytic site [active] 391735001070 dimer interface [polypeptide binding]; other site 391735001071 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 391735001072 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 391735001073 ATP binding site [chemical binding]; other site 391735001074 Mg++ binding site [ion binding]; other site 391735001075 motif III; other site 391735001076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391735001077 nucleotide binding region [chemical binding]; other site 391735001078 ATP-binding site [chemical binding]; other site 391735001079 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735001080 TM-ABC transporter signature motif; other site 391735001081 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735001082 TM-ABC transporter signature motif; other site 391735001083 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735001084 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735001085 Walker A/P-loop; other site 391735001086 ATP binding site [chemical binding]; other site 391735001087 Q-loop/lid; other site 391735001088 ABC transporter signature motif; other site 391735001089 Walker B; other site 391735001090 D-loop; other site 391735001091 H-loop/switch region; other site 391735001092 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735001093 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735001094 Walker A/P-loop; other site 391735001095 ATP binding site [chemical binding]; other site 391735001096 Q-loop/lid; other site 391735001097 ABC transporter signature motif; other site 391735001098 Walker B; other site 391735001099 D-loop; other site 391735001100 H-loop/switch region; other site 391735001101 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735001102 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 391735001103 putative ligand binding site [chemical binding]; other site 391735001104 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735001105 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 391735001106 putative ligand binding site [chemical binding]; other site 391735001107 Arginase family; Region: Arginase; cl00306 391735001108 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 391735001109 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735001110 substrate binding pocket [chemical binding]; other site 391735001111 membrane-bound complex binding site; other site 391735001112 hinge residues; other site 391735001113 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391735001114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735001115 dimer interface [polypeptide binding]; other site 391735001116 conserved gate region; other site 391735001117 putative PBP binding loops; other site 391735001118 ABC-ATPase subunit interface; other site 391735001119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735001120 dimer interface [polypeptide binding]; other site 391735001121 conserved gate region; other site 391735001122 putative PBP binding loops; other site 391735001123 ABC-ATPase subunit interface; other site 391735001124 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 391735001125 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735001126 Walker A/P-loop; other site 391735001127 ATP binding site [chemical binding]; other site 391735001128 Q-loop/lid; other site 391735001129 ABC transporter signature motif; other site 391735001130 Walker B; other site 391735001131 D-loop; other site 391735001132 H-loop/switch region; other site 391735001133 hypothetical protein; Provisional; Region: PRK07524 391735001134 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391735001135 PYR/PP interface [polypeptide binding]; other site 391735001136 dimer interface [polypeptide binding]; other site 391735001137 TPP binding site [chemical binding]; other site 391735001138 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391735001139 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 391735001140 TPP-binding site [chemical binding]; other site 391735001141 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 391735001142 intersubunit interface [polypeptide binding]; other site 391735001143 active site 391735001144 Zn2+ binding site [ion binding]; other site 391735001145 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 391735001146 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 391735001147 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 391735001148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 391735001149 dimer interface [polypeptide binding]; other site 391735001150 phosphorylation site [posttranslational modification] 391735001151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735001152 ATP binding site [chemical binding]; other site 391735001153 Mg2+ binding site [ion binding]; other site 391735001154 G-X-G motif; other site 391735001155 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 391735001156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735001157 active site 391735001158 phosphorylation site [posttranslational modification] 391735001159 intermolecular recognition site; other site 391735001160 dimerization interface [polypeptide binding]; other site 391735001161 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 391735001162 DNA binding site [nucleotide binding] 391735001163 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 391735001164 Protein export membrane protein; Region: SecD_SecF; cl14618 391735001165 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 391735001166 NodT family; Region: outer_NodT; TIGR01845 391735001167 Outer membrane efflux protein; Region: OEP; pfam02321 391735001168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 391735001169 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 391735001170 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735001171 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356 391735001172 putative ligand binding site [chemical binding]; other site 391735001173 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735001174 TM-ABC transporter signature motif; other site 391735001175 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735001176 TM-ABC transporter signature motif; other site 391735001177 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 391735001178 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735001179 Walker A/P-loop; other site 391735001180 ATP binding site [chemical binding]; other site 391735001181 Q-loop/lid; other site 391735001182 ABC transporter signature motif; other site 391735001183 Walker B; other site 391735001184 D-loop; other site 391735001185 H-loop/switch region; other site 391735001186 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735001187 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 391735001188 Walker A/P-loop; other site 391735001189 ATP binding site [chemical binding]; other site 391735001190 Q-loop/lid; other site 391735001191 ABC transporter signature motif; other site 391735001192 Walker B; other site 391735001193 D-loop; other site 391735001194 H-loop/switch region; other site 391735001195 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 391735001196 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391735001197 AMP-binding domain protein; Validated; Region: PRK08315 391735001198 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735001199 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 391735001200 hexamer interface [polypeptide binding]; other site 391735001201 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 391735001202 Walker A motif; other site 391735001203 ATP binding site [chemical binding]; other site 391735001204 Walker B motif; other site 391735001205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735001206 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 391735001207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735001208 active site 391735001209 phosphorylation site [posttranslational modification] 391735001210 intermolecular recognition site; other site 391735001211 dimerization interface [polypeptide binding]; other site 391735001212 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 391735001213 DNA binding site [nucleotide binding] 391735001214 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 391735001215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 391735001216 dimer interface [polypeptide binding]; other site 391735001217 phosphorylation site [posttranslational modification] 391735001218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735001219 ATP binding site [chemical binding]; other site 391735001220 Mg2+ binding site [ion binding]; other site 391735001221 G-X-G motif; other site 391735001222 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 391735001223 oligomer interface [polypeptide binding]; other site 391735001224 active site residues [active] 391735001225 LysE type translocator; Region: LysE; cl00565 391735001226 aspartate aminotransferase; Provisional; Region: PRK08361 391735001227 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391735001228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735001229 homodimer interface [polypeptide binding]; other site 391735001230 catalytic residue [active] 391735001231 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391735001232 catalytic core [active] 391735001233 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 391735001234 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391735001235 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 391735001236 Creatinine amidohydrolase; Region: Creatininase; cl00618 391735001237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 391735001238 CHASE domain; Region: CHASE; cl01369 391735001239 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 391735001240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 391735001241 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 391735001242 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 391735001243 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391735001244 metal binding site [ion binding]; metal-binding site 391735001245 active site 391735001246 I-site; other site 391735001247 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391735001248 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 391735001249 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 391735001250 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 391735001251 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 391735001252 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 391735001253 LamB/YcsF family; Region: LamB_YcsF; cl00664 391735001254 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 391735001255 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391735001256 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 391735001257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391735001258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735001259 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 391735001260 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735001261 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391735001262 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 391735001263 Walker A/P-loop; other site 391735001264 ATP binding site [chemical binding]; other site 391735001265 Q-loop/lid; other site 391735001266 ABC transporter signature motif; other site 391735001267 Walker B; other site 391735001268 D-loop; other site 391735001269 H-loop/switch region; other site 391735001270 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391735001271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735001272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735001273 Putative cyclase; Region: Cyclase; cl00814 391735001274 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 391735001275 dimer interface [polypeptide binding]; other site 391735001276 allosteric magnesium binding site [ion binding]; other site 391735001277 active site 391735001278 aspartate-rich active site metal binding site; other site 391735001279 Schiff base residues; other site 391735001280 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 391735001281 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 391735001282 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 391735001283 trimer interface [polypeptide binding]; other site 391735001284 dimer interface [polypeptide binding]; other site 391735001285 putative active site [active] 391735001286 Peptidase family M48; Region: Peptidase_M48; cl12018 391735001287 Membrane protein of unknown function; Region: DUF360; cl00850 391735001288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735001289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735001290 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391735001291 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 391735001292 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 391735001293 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 391735001294 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391735001295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 391735001296 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 391735001297 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 391735001298 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 391735001299 CAP-like domain; other site 391735001300 Active site [active] 391735001301 primary dimer interface [polypeptide binding]; other site 391735001302 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 391735001303 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391735001304 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 391735001305 EamA-like transporter family; Region: EamA; cl01037 391735001306 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 391735001307 homotrimer interaction site [polypeptide binding]; other site 391735001308 putative active site [active] 391735001309 Competence protein; Region: Competence; cl00471 391735001310 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391735001311 Uncharacterized conserved protein [Function unknown]; Region: COG2308 391735001312 Domain of unknown function (DUF404); Region: DUF404; pfam04169 391735001313 Domain of unknown function (DUF407); Region: DUF407; pfam04174 391735001314 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 391735001315 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735001316 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 391735001317 putative transposase OrfB; Reviewed; Region: PHA02517 391735001318 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391735001319 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 391735001320 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735001321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735001322 dimer interface [polypeptide binding]; other site 391735001323 conserved gate region; other site 391735001324 ABC-ATPase subunit interface; other site 391735001325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735001326 dimer interface [polypeptide binding]; other site 391735001327 conserved gate region; other site 391735001328 putative PBP binding loops; other site 391735001329 ABC-ATPase subunit interface; other site 391735001330 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391735001331 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735001332 Walker A/P-loop; other site 391735001333 ATP binding site [chemical binding]; other site 391735001334 Q-loop/lid; other site 391735001335 ABC transporter signature motif; other site 391735001336 Walker B; other site 391735001337 D-loop; other site 391735001338 H-loop/switch region; other site 391735001339 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735001340 Walker A/P-loop; other site 391735001341 ATP binding site [chemical binding]; other site 391735001342 Q-loop/lid; other site 391735001343 ABC transporter signature motif; other site 391735001344 Walker B; other site 391735001345 D-loop; other site 391735001346 H-loop/switch region; other site 391735001347 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735001348 Predicted acyl esterases [General function prediction only]; Region: COG2936 391735001349 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 391735001350 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 391735001351 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735001352 active site 391735001353 cytosine deaminase; Provisional; Region: PRK05985 391735001354 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 391735001355 active site 391735001356 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 391735001357 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735001358 active site 391735001359 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735001360 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391735001361 Walker A/P-loop; other site 391735001362 ATP binding site [chemical binding]; other site 391735001363 Q-loop/lid; other site 391735001364 ABC transporter signature motif; other site 391735001365 Walker B; other site 391735001366 D-loop; other site 391735001367 H-loop/switch region; other site 391735001368 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735001369 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735001370 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735001371 Walker A/P-loop; other site 391735001372 ATP binding site [chemical binding]; other site 391735001373 Q-loop/lid; other site 391735001374 ABC transporter signature motif; other site 391735001375 Walker B; other site 391735001376 D-loop; other site 391735001377 H-loop/switch region; other site 391735001378 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735001379 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391735001380 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391735001381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735001382 dimer interface [polypeptide binding]; other site 391735001383 conserved gate region; other site 391735001384 putative PBP binding loops; other site 391735001385 ABC-ATPase subunit interface; other site 391735001386 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735001387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735001388 dimer interface [polypeptide binding]; other site 391735001389 conserved gate region; other site 391735001390 putative PBP binding loops; other site 391735001391 ABC-ATPase subunit interface; other site 391735001392 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391735001393 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 391735001394 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 391735001395 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391735001396 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 391735001397 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 391735001398 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 391735001399 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cd00216 391735001400 Trp docking motif; other site 391735001401 'Velcro' closure; other site 391735001402 active site 391735001403 Cytochrome c; Region: Cytochrom_C; cl11414 391735001404 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735001405 enoyl-CoA hydratase; Provisional; Region: PRK06688 391735001406 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735001407 substrate binding site [chemical binding]; other site 391735001408 oxyanion hole (OAH) forming residues; other site 391735001409 trimer interface [polypeptide binding]; other site 391735001410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735001411 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735001412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735001413 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735001414 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 391735001415 substrate binding pocket [chemical binding]; other site 391735001416 dimerization interface [polypeptide binding]; other site 391735001417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735001418 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735001419 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735001420 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 391735001421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735001422 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391735001423 dimerization interface [polypeptide binding]; other site 391735001424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735001425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735001426 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 391735001427 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 391735001428 putative active site [active] 391735001429 putative catalytic site [active] 391735001430 hypothetical protein; Provisional; Region: PRK11820 391735001431 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 391735001432 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 391735001433 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 391735001434 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 391735001435 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 391735001436 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 391735001437 enoyl-CoA hydratase; Provisional; Region: PRK05862 391735001438 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735001439 substrate binding site [chemical binding]; other site 391735001440 oxyanion hole (OAH) forming residues; other site 391735001441 trimer interface [polypeptide binding]; other site 391735001442 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 391735001443 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 391735001444 Zn binding site [ion binding]; other site 391735001445 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 391735001446 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 391735001447 dimerization domain [polypeptide binding]; other site 391735001448 dimer interface [polypeptide binding]; other site 391735001449 catalytic residues [active] 391735001450 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735001451 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 391735001452 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 391735001453 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 391735001454 MOSC domain; Region: MOSC; pfam03473 391735001455 GTP-binding protein YchF; Reviewed; Region: PRK09601 391735001456 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 391735001457 G1 box; other site 391735001458 GTP/Mg2+ binding site [chemical binding]; other site 391735001459 Switch I region; other site 391735001460 G2 box; other site 391735001461 Switch II region; other site 391735001462 G3 box; other site 391735001463 G4 box; other site 391735001464 G5 box; other site 391735001465 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 391735001466 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 391735001467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 391735001468 lipoyl synthase; Provisional; Region: PRK05481 391735001469 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 391735001470 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 391735001471 Protein of unknown function (DUF493); Region: DUF493; cl01102 391735001472 ATP synthase A chain; Region: ATP-synt_A; cl00413 391735001473 ATP synthase subunit C; Region: ATP-synt_C; cl00466 391735001474 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 391735001475 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 391735001476 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 391735001477 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 391735001478 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 391735001479 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 391735001480 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 391735001481 beta subunit interaction interface [polypeptide binding]; other site 391735001482 Walker A motif; other site 391735001483 ATP binding site [chemical binding]; other site 391735001484 Walker B motif; other site 391735001485 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 391735001486 ATP synthase; Region: ATP-synt; cl00365 391735001487 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 391735001488 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 391735001489 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 391735001490 alpha subunit interaction interface [polypeptide binding]; other site 391735001491 Walker A motif; other site 391735001492 ATP binding site [chemical binding]; other site 391735001493 Walker B motif; other site 391735001494 inhibitor binding site; inhibition site 391735001495 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 391735001496 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 391735001497 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 391735001498 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 391735001499 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 391735001500 Phosphotransferase enzyme family; Region: APH; pfam01636 391735001501 active site 391735001502 substrate binding site [chemical binding]; other site 391735001503 ATP binding site [chemical binding]; other site 391735001504 heat shock protein 90; Provisional; Region: PRK05218 391735001505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 391735001506 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 391735001507 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391735001508 RNA binding surface [nucleotide binding]; other site 391735001509 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 391735001510 active site 391735001511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 391735001512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735001513 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735001514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735001515 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735001516 Predicted ATPase [General function prediction only]; Region: COG4637 391735001517 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735001518 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 391735001519 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391735001520 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735001521 enoyl-CoA hydratase; Provisional; Region: PRK08258 391735001522 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735001523 substrate binding site [chemical binding]; other site 391735001524 oxyanion hole (OAH) forming residues; other site 391735001525 trimer interface [polypeptide binding]; other site 391735001526 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735001527 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735001528 active site 391735001529 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 391735001530 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 391735001531 homotrimer interaction site [polypeptide binding]; other site 391735001532 putative active site [active] 391735001533 Type II transport protein GspH; Region: GspH; pfam12019 391735001534 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 391735001535 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 391735001536 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 391735001537 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 391735001538 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 391735001539 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 391735001540 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 391735001541 Transposase domain (DUF772); Region: DUF772; cl12084 391735001542 recombination protein RecR; Reviewed; Region: recR; PRK00076 391735001543 RecR protein; Region: RecR; pfam02132 391735001544 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 391735001545 putative active site [active] 391735001546 putative metal-binding site [ion binding]; other site 391735001547 tetramer interface [polypeptide binding]; other site 391735001548 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 391735001549 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 391735001550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735001551 Walker A motif; other site 391735001552 ATP binding site [chemical binding]; other site 391735001553 Walker B motif; other site 391735001554 arginine finger; other site 391735001555 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 391735001556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735001557 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 391735001558 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 391735001559 active site 391735001560 catalytic residues [active] 391735001561 metal binding site [ion binding]; metal-binding site 391735001562 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 391735001563 putative deacylase active site [active] 391735001564 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 391735001565 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 391735001566 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-; Region: DsbA_HCCA_Iso; cd03022 391735001567 putative catalytic residue [active] 391735001568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735001569 putative substrate translocation pore; other site 391735001570 metabolite-proton symporter; Region: 2A0106; TIGR00883 391735001571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735001572 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735001573 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735001574 OsmC-like protein; Region: OsmC; cl00767 391735001575 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 391735001576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735001577 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735001578 Restriction endonuclease XhoI; Region: XhoI; pfam04555 391735001579 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391735001580 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391735001581 DNA binding site [nucleotide binding] 391735001582 domain linker motif; other site 391735001583 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 391735001584 dimerization interface [polypeptide binding]; other site 391735001585 ligand binding site [chemical binding]; other site 391735001586 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 391735001587 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735001588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735001589 dimer interface [polypeptide binding]; other site 391735001590 conserved gate region; other site 391735001591 putative PBP binding loops; other site 391735001592 ABC-ATPase subunit interface; other site 391735001593 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391735001594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735001595 dimer interface [polypeptide binding]; other site 391735001596 conserved gate region; other site 391735001597 putative PBP binding loops; other site 391735001598 ABC-ATPase subunit interface; other site 391735001599 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735001600 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735001601 Walker A/P-loop; other site 391735001602 ATP binding site [chemical binding]; other site 391735001603 Q-loop/lid; other site 391735001604 ABC transporter signature motif; other site 391735001605 Walker B; other site 391735001606 D-loop; other site 391735001607 H-loop/switch region; other site 391735001608 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735001609 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 391735001610 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735001611 Walker A/P-loop; other site 391735001612 ATP binding site [chemical binding]; other site 391735001613 Q-loop/lid; other site 391735001614 ABC transporter signature motif; other site 391735001615 Walker B; other site 391735001616 D-loop; other site 391735001617 H-loop/switch region; other site 391735001618 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735001619 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391735001620 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 391735001621 substrate binding site [chemical binding]; other site 391735001622 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 391735001623 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 391735001624 serine/threonine dehydratase; Validated; Region: PRK07048 391735001625 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391735001626 tetramer interface [polypeptide binding]; other site 391735001627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735001628 catalytic residue [active] 391735001629 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 391735001630 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 391735001631 active site 391735001632 catalytic triad [active] 391735001633 oxyanion hole [active] 391735001634 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391735001635 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 391735001636 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 391735001637 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735001638 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735001639 Walker A/P-loop; other site 391735001640 ATP binding site [chemical binding]; other site 391735001641 Q-loop/lid; other site 391735001642 ABC transporter signature motif; other site 391735001643 Walker B; other site 391735001644 D-loop; other site 391735001645 H-loop/switch region; other site 391735001646 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735001647 TM-ABC transporter signature motif; other site 391735001648 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391735001649 ligand binding site [chemical binding]; other site 391735001650 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391735001651 ligand binding site [chemical binding]; other site 391735001652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735001653 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735001654 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735001655 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 391735001656 substrate binding site [chemical binding]; other site 391735001657 ATP binding site [chemical binding]; other site 391735001658 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735001659 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 391735001660 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 391735001661 active site 391735001662 benzoate transport; Region: 2A0115; TIGR00895 391735001663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735001664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735001665 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391735001666 CoenzymeA binding site [chemical binding]; other site 391735001667 subunit interaction site [polypeptide binding]; other site 391735001668 PHB binding site; other site 391735001669 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735001670 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 391735001671 putative ligand binding site [chemical binding]; other site 391735001672 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735001673 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 391735001674 putative ligand binding site [chemical binding]; other site 391735001675 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099 391735001676 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 391735001677 mce related protein; Region: MCE; cl03606 391735001678 Domain of unknown function DUF140; Region: DUF140; cl00510 391735001679 Predicted transcriptional regulator [Transcription]; Region: COG5340 391735001680 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 391735001681 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 391735001682 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 391735001683 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 391735001684 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 391735001685 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 391735001686 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 391735001687 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 391735001688 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 391735001689 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 391735001690 Flagellar L-ring protein; Region: FlgH; cl00905 391735001691 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 391735001692 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 391735001693 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 391735001694 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 391735001695 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 391735001696 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 391735001697 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 391735001698 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 391735001699 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 391735001700 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 391735001701 Flagellar hook capping protein; Region: FlgD; cl04347 391735001702 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 391735001703 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 391735001704 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 391735001705 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 391735001706 SAF domain; Region: SAF; cl00555 391735001707 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 391735001708 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 391735001709 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 391735001710 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 391735001711 active site 391735001712 HIGH motif; other site 391735001713 KMSK motif region; other site 391735001714 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 391735001715 tRNA binding surface [nucleotide binding]; other site 391735001716 anticodon binding site; other site 391735001717 Sporulation related domain; Region: SPOR; cl10051 391735001718 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 391735001719 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 391735001720 catalytic residues [active] 391735001721 hinge region; other site 391735001722 alpha helical domain; other site 391735001723 OstA-like protein; Region: OstA; cl00844 391735001724 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 391735001725 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 391735001726 Walker A/P-loop; other site 391735001727 ATP binding site [chemical binding]; other site 391735001728 Q-loop/lid; other site 391735001729 ABC transporter signature motif; other site 391735001730 Walker B; other site 391735001731 D-loop; other site 391735001732 H-loop/switch region; other site 391735001733 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 391735001734 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 391735001735 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 391735001736 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 391735001737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735001738 Competence-damaged protein; Region: CinA; cl00666 391735001739 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 391735001740 tetramer interfaces [polypeptide binding]; other site 391735001741 binuclear metal-binding site [ion binding]; other site 391735001742 thiamine monophosphate kinase; Provisional; Region: PRK05731 391735001743 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 391735001744 ATP binding site [chemical binding]; other site 391735001745 dimerization interface [polypeptide binding]; other site 391735001746 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 391735001747 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 391735001748 Protein of unknown function (DUF525); Region: DUF525; cl01119 391735001749 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 391735001750 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 391735001751 substrate binding site [chemical binding]; other site 391735001752 hexamer interface [polypeptide binding]; other site 391735001753 metal binding site [ion binding]; metal-binding site 391735001754 MAPEG family; Region: MAPEG; cl09190 391735001755 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391735001756 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735001757 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 391735001758 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 391735001759 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391735001760 catalytic residue [active] 391735001761 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391735001762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735001763 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 391735001764 RNA/DNA hybrid binding site [nucleotide binding]; other site 391735001765 active site 391735001766 Domain of unknown function (DUF955); Region: DUF955; cl01076 391735001767 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 391735001768 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391735001769 Ligand Binding Site [chemical binding]; other site 391735001770 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among Gram-...; Region: OMPLA; cl00248 391735001771 substrate binding site [chemical binding]; other site 391735001772 dimerization interface [polypeptide binding]; other site 391735001773 active site 391735001774 calcium binding site [ion binding]; other site 391735001775 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 391735001776 UvrD/REP helicase; Region: UvrD-helicase; cl14126 391735001777 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 391735001778 30S subunit binding site; other site 391735001779 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 391735001780 active site 391735001781 phosphorylation site [posttranslational modification] 391735001782 HPr kinase/phosphorylase; Provisional; Region: PRK05428 391735001783 DRTGG domain; Region: DRTGG; cl12147 391735001784 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 391735001785 Hpr binding site; other site 391735001786 active site 391735001787 homohexamer subunit interaction site [polypeptide binding]; other site 391735001788 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391735001789 metal binding site 2 [ion binding]; metal-binding site 391735001790 putative DNA binding helix; other site 391735001791 metal binding site 1 [ion binding]; metal-binding site 391735001792 dimer interface [polypeptide binding]; other site 391735001793 structural Zn2+ binding site [ion binding]; other site 391735001794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 391735001795 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 391735001796 putative dimer interface [polypeptide binding]; other site 391735001797 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 391735001798 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735001799 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735001800 Walker A/P-loop; other site 391735001801 ATP binding site [chemical binding]; other site 391735001802 Q-loop/lid; other site 391735001803 ABC transporter signature motif; other site 391735001804 Walker B; other site 391735001805 D-loop; other site 391735001806 H-loop/switch region; other site 391735001807 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735001808 TM-ABC transporter signature motif; other site 391735001809 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735001810 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735001811 Walker A/P-loop; other site 391735001812 ATP binding site [chemical binding]; other site 391735001813 Q-loop/lid; other site 391735001814 ABC transporter signature motif; other site 391735001815 Walker B; other site 391735001816 D-loop; other site 391735001817 H-loop/switch region; other site 391735001818 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735001819 TM-ABC transporter signature motif; other site 391735001820 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735001821 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 391735001822 putative ligand binding site [chemical binding]; other site 391735001823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735001824 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391735001825 putative substrate translocation pore; other site 391735001826 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 391735001827 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391735001828 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391735001829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735001830 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion...; Region: enolase_like; cl14814 391735001831 metal binding site [ion binding]; metal-binding site 391735001832 substrate binding pocket [chemical binding]; other site 391735001833 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391735001834 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 391735001835 Walker A/P-loop; other site 391735001836 ATP binding site [chemical binding]; other site 391735001837 Q-loop/lid; other site 391735001838 ABC transporter signature motif; other site 391735001839 Walker B; other site 391735001840 D-loop; other site 391735001841 H-loop/switch region; other site 391735001842 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735001843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735001844 dimer interface [polypeptide binding]; other site 391735001845 conserved gate region; other site 391735001846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735001847 ABC-ATPase subunit interface; other site 391735001848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735001849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735001850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391735001851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735001852 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 391735001853 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 391735001854 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 391735001855 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 391735001856 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 391735001857 FAD binding domain; Region: FAD_binding_4; pfam01565 391735001858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735001859 BON domain; Region: BON; cl02771 391735001860 BON domain; Region: BON; cl02771 391735001861 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 391735001862 active site 391735001863 dimer interface [polypeptide binding]; other site 391735001864 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 391735001865 Predicted methyltransferases [General function prediction only]; Region: COG0313 391735001866 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 391735001867 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 391735001868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 391735001869 S-adenosylmethionine binding site [chemical binding]; other site 391735001870 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 391735001871 Probable Catalytic site [active] 391735001872 metal binding site [ion binding]; metal-binding site 391735001873 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391735001874 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 391735001875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735001876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735001877 L-rhamnonate dehydratase; Provisional; Region: PRK15440 391735001878 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved...; Region: MR_like_2; cd03327 391735001879 putative active site pocket [active] 391735001880 putative metal binding site [ion binding]; other site 391735001881 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 391735001882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735001883 putative substrate translocation pore; other site 391735001884 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735001885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735001886 NAD(P) binding site [chemical binding]; other site 391735001887 active site 391735001888 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 391735001889 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735001890 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 391735001891 putative dimerization interface [polypeptide binding]; other site 391735001892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735001893 Rrf2 family protein; Region: rrf2_super; TIGR00738 391735001894 acyl-CoA synthetase; Validated; Region: PRK08316 391735001895 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735001896 Uncharacterized protein conserved in bacteria (DUF2257); Region: DUF2257; cl01794 391735001897 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391735001898 Ligand Binding Site [chemical binding]; other site 391735001899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735001900 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735001901 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 391735001902 catalytic residues [active] 391735001903 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 391735001904 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 391735001905 UvrD/REP helicase; Region: UvrD-helicase; cl14126 391735001906 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 391735001907 UvrD/REP helicase; Region: UvrD-helicase; cl14126 391735001908 UvrD/REP helicase; Region: UvrD-helicase; cl14126 391735001909 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 391735001910 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735001911 DNA-binding site [nucleotide binding]; DNA binding site 391735001912 FCD domain; Region: FCD; cl11656 391735001913 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 391735001914 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 391735001915 tetramer interface [polypeptide binding]; other site 391735001916 active site 391735001917 Mg2+/Mn2+ binding site [ion binding]; other site 391735001918 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 391735001919 2-methylcitrate dehydratase; Region: prpD; TIGR02330 391735001920 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 391735001921 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 391735001922 FAD binding site [chemical binding]; other site 391735001923 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 391735001924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735001925 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 391735001926 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401 391735001927 oligomerization interface [polypeptide binding]; other site 391735001928 active site 391735001929 NAD+ binding site [chemical binding]; other site 391735001930 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 391735001931 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 391735001932 G1 box; other site 391735001933 putative GEF interaction site [polypeptide binding]; other site 391735001934 GTP/Mg2+ binding site [chemical binding]; other site 391735001935 Switch I region; other site 391735001936 G2 box; other site 391735001937 G3 box; other site 391735001938 Switch II region; other site 391735001939 G4 box; other site 391735001940 G5 box; other site 391735001941 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 391735001942 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 391735001943 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 391735001944 inhibitor-cofactor binding pocket; inhibition site 391735001945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735001946 catalytic residue [active] 391735001947 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 391735001948 putative catalytic cysteine [active] 391735001949 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 391735001950 putative hexamer interface [polypeptide binding]; other site 391735001951 putative hexagonal pore; other site 391735001952 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 391735001953 putative hexamer interface [polypeptide binding]; other site 391735001954 putative hexagonal pore; other site 391735001955 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 391735001956 Hexamer/Pentamer interface [polypeptide binding]; other site 391735001957 central pore; other site 391735001958 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 391735001959 Hexamer interface [polypeptide binding]; other site 391735001960 Hexagonal pore residue; other site 391735001961 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 391735001962 putative hexamer interface [polypeptide binding]; other site 391735001963 putative hexagonal pore; other site 391735001964 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 391735001965 putative hexamer interface [polypeptide binding]; other site 391735001966 putative hexagonal pore; other site 391735001967 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 391735001968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735001969 NAD(P) binding site [chemical binding]; other site 391735001970 active site 391735001971 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 391735001972 acetate--CoA ligase; Provisional; Region: PLN03052 391735001973 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391735001974 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735001975 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 391735001976 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 391735001977 HipA N-terminal domain; Region: couple_hipA; TIGR03071 391735001978 HipA-like N-terminal domain; Region: HipA_N; pfam07805 391735001979 HipA-like C-terminal domain; Region: HipA_C; pfam07804 391735001980 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 391735001981 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 391735001982 Walker A/P-loop; other site 391735001983 ATP binding site [chemical binding]; other site 391735001984 Q-loop/lid; other site 391735001985 ABC transporter signature motif; other site 391735001986 Walker B; other site 391735001987 D-loop; other site 391735001988 H-loop/switch region; other site 391735001989 ABC-2 type transporter; Region: ABC2_membrane; cl11417 391735001990 PPIC-type PPIASE domain; Region: Rotamase; cl08278 391735001991 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 391735001992 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 391735001993 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 391735001994 General secretion pathway protein M; Region: GspM_II; pfam10741 391735001995 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 391735001996 general secretion pathway protein J; Validated; Region: PRK08808 391735001997 Prepilin peptidase dependent protein C; Region: DUF3728; cl08108 391735001998 general secretion pathway protein I; Region: gspI; TIGR01707 391735001999 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 391735002000 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 391735002001 general secretion pathway protein F; Region: GspF; TIGR02120 391735002002 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 391735002003 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 391735002004 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 391735002005 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 391735002006 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 391735002007 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 391735002008 Walker A motif; other site 391735002009 ATP binding site [chemical binding]; other site 391735002010 Walker B motif; other site 391735002011 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 391735002012 GtrA-like protein; Region: GtrA; cl00971 391735002013 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 391735002014 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 391735002015 putative trimer interface [polypeptide binding]; other site 391735002016 putative active site [active] 391735002017 putative substrate binding site [chemical binding]; other site 391735002018 putative CoA binding site [chemical binding]; other site 391735002019 Cupin domain; Region: Cupin_2; cl09118 391735002020 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 391735002021 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 391735002022 Ligand binding site [chemical binding]; other site 391735002023 Putative Catalytic site [active] 391735002024 DXD motif; other site 391735002025 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 391735002026 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 391735002027 inhibitor-cofactor binding pocket; inhibition site 391735002028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735002029 catalytic residue [active] 391735002030 Cupin domain; Region: Cupin_2; cl09118 391735002031 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 391735002032 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 391735002033 substrate binding site [chemical binding]; other site 391735002034 tetramer interface [polypeptide binding]; other site 391735002035 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 391735002036 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 391735002037 NADP binding site [chemical binding]; other site 391735002038 active site 391735002039 putative substrate binding site [chemical binding]; other site 391735002040 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 391735002041 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 391735002042 NAD binding site [chemical binding]; other site 391735002043 substrate binding site [chemical binding]; other site 391735002044 homodimer interface [polypeptide binding]; other site 391735002045 active site 391735002046 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 391735002047 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 391735002048 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 391735002049 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 391735002050 nucleotide binding site/active site [active] 391735002051 HIT family signature motif; other site 391735002052 catalytic residue [active] 391735002053 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 391735002054 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 391735002055 active site 391735002056 nucleophile elbow; other site 391735002057 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 391735002058 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 391735002059 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 391735002060 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 391735002061 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 391735002062 putative active site [active] 391735002063 putative substrate binding site [chemical binding]; other site 391735002064 putative cosubstrate binding site; other site 391735002065 catalytic site [active] 391735002066 Protein of unknown function, DUF399; Region: DUF399; cl01139 391735002067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 391735002068 binding surface 391735002069 TPR motif; other site 391735002070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735002071 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735002072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735002073 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735002074 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735002075 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 391735002076 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 391735002077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 391735002078 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391735002079 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 391735002080 Walker A/P-loop; other site 391735002081 ATP binding site [chemical binding]; other site 391735002082 Q-loop/lid; other site 391735002083 ABC transporter signature motif; other site 391735002084 Walker B; other site 391735002085 D-loop; other site 391735002086 H-loop/switch region; other site 391735002087 M28, and M42; Region: Zinc_peptidase_like; cl14876 391735002088 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 391735002089 metal binding site [ion binding]; metal-binding site 391735002090 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391735002091 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391735002092 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 391735002093 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735002094 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391735002095 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735002096 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 391735002097 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 391735002098 inhibitor site; inhibition site 391735002099 active site 391735002100 dimer interface [polypeptide binding]; other site 391735002101 catalytic residue [active] 391735002102 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735002103 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391735002104 substrate binding pocket [chemical binding]; other site 391735002105 membrane-bound complex binding site; other site 391735002106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002107 dimer interface [polypeptide binding]; other site 391735002108 conserved gate region; other site 391735002109 putative PBP binding loops; other site 391735002110 ABC-ATPase subunit interface; other site 391735002111 dihydropyrimidinase; Provisional; Region: PRK13404 391735002112 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like...; Region: D-HYD; cd01314 391735002113 tetramer interface [polypeptide binding]; other site 391735002114 active site 391735002115 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391735002116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735002117 DNA-binding site [nucleotide binding]; DNA binding site 391735002118 FCD domain; Region: FCD; cl11656 391735002119 RES domain; Region: RES; cl02411 391735002120 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735002121 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735002122 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 391735002123 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735002124 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 391735002125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391735002126 non-specific DNA binding site [nucleotide binding]; other site 391735002127 salt bridge; other site 391735002128 sequence-specific DNA binding site [nucleotide binding]; other site 391735002129 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 391735002130 ADP binding site [chemical binding]; other site 391735002131 magnesium binding site [ion binding]; other site 391735002132 putative shikimate binding site; other site 391735002133 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 391735002134 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735002135 substrate binding site [chemical binding]; other site 391735002136 oxyanion hole (OAH) forming residues; other site 391735002137 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 391735002138 oxyanion hole (OAH) forming residues; other site 391735002139 trimer interface [polypeptide binding]; other site 391735002140 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 391735002141 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 391735002142 4Fe-4S binding domain; Region: Fer4; cl02805 391735002143 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron...; Region: FNR_like; cl06868 391735002144 FAD binding pocket [chemical binding]; other site 391735002145 conserved FAD binding motif [chemical binding]; other site 391735002146 phosphate binding motif [ion binding]; other site 391735002147 beta-alpha-beta structure motif; other site 391735002148 NAD binding pocket [chemical binding]; other site 391735002149 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 391735002150 classical (c) SDRs; Region: SDR_c; cd05233 391735002151 NAD(P) binding site [chemical binding]; other site 391735002152 active site 391735002153 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 391735002154 putative ligand binding site [chemical binding]; other site 391735002155 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 391735002156 putative ligand binding site [chemical binding]; other site 391735002157 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 391735002158 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735002159 Walker A/P-loop; other site 391735002160 ATP binding site [chemical binding]; other site 391735002161 Q-loop/lid; other site 391735002162 ABC transporter signature motif; other site 391735002163 Walker B; other site 391735002164 D-loop; other site 391735002165 H-loop/switch region; other site 391735002166 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735002167 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735002168 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735002169 TM-ABC transporter signature motif; other site 391735002170 Dehydratase family; Region: ILVD_EDD; cl00340 391735002171 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 391735002172 putative transporter; Provisional; Region: PRK11660 391735002173 Sulfate transporter family; Region: Sulfate_transp; cl00967 391735002174 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 391735002175 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391735002176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735002177 DNA-binding site [nucleotide binding]; DNA binding site 391735002178 FCD domain; Region: FCD; cl11656 391735002179 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 391735002180 acetylornithine deacetylase; Validated; Region: PRK06915 391735002181 metal binding site [ion binding]; metal-binding site 391735002182 dimer interface [polypeptide binding]; other site 391735002183 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391735002184 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 391735002185 nickel transporter permease NikB; Provisional; Region: PRK10352 391735002186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002187 dimer interface [polypeptide binding]; other site 391735002188 conserved gate region; other site 391735002189 putative PBP binding loops; other site 391735002190 ABC-ATPase subunit interface; other site 391735002191 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 391735002192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002193 dimer interface [polypeptide binding]; other site 391735002194 conserved gate region; other site 391735002195 putative PBP binding loops; other site 391735002196 ABC-ATPase subunit interface; other site 391735002197 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391735002198 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 391735002199 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391735002200 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 391735002201 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391735002202 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735002203 Walker A/P-loop; other site 391735002204 ATP binding site [chemical binding]; other site 391735002205 Q-loop/lid; other site 391735002206 ABC transporter signature motif; other site 391735002207 Walker B; other site 391735002208 D-loop; other site 391735002209 H-loop/switch region; other site 391735002210 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735002211 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735002212 Walker A/P-loop; other site 391735002213 ATP binding site [chemical binding]; other site 391735002214 Q-loop/lid; other site 391735002215 ABC transporter signature motif; other site 391735002216 Walker B; other site 391735002217 D-loop; other site 391735002218 H-loop/switch region; other site 391735002219 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735002220 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735002221 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391735002222 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735002223 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 391735002224 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735002225 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 391735002226 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 391735002227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002228 dimer interface [polypeptide binding]; other site 391735002229 conserved gate region; other site 391735002230 putative PBP binding loops; other site 391735002231 ABC-ATPase subunit interface; other site 391735002232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002233 dimer interface [polypeptide binding]; other site 391735002234 conserved gate region; other site 391735002235 putative PBP binding loops; other site 391735002236 ABC-ATPase subunit interface; other site 391735002237 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391735002238 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735002239 Walker A/P-loop; other site 391735002240 ATP binding site [chemical binding]; other site 391735002241 Q-loop/lid; other site 391735002242 ABC transporter signature motif; other site 391735002243 Walker B; other site 391735002244 D-loop; other site 391735002245 H-loop/switch region; other site 391735002246 TOBE domain; Region: TOBE_2; cl01440 391735002247 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391735002248 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391735002249 DNA binding site [nucleotide binding] 391735002250 domain linker motif; other site 391735002251 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 391735002252 putative dimerization interface [polypeptide binding]; other site 391735002253 putative ligand binding site [chemical binding]; other site 391735002254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735002255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002256 dimer interface [polypeptide binding]; other site 391735002257 conserved gate region; other site 391735002258 putative PBP binding loops; other site 391735002259 ABC-ATPase subunit interface; other site 391735002260 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391735002261 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 391735002262 Walker A/P-loop; other site 391735002263 ATP binding site [chemical binding]; other site 391735002264 Q-loop/lid; other site 391735002265 ABC transporter signature motif; other site 391735002266 Walker B; other site 391735002267 D-loop; other site 391735002268 H-loop/switch region; other site 391735002269 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 391735002270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735002271 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 391735002272 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 391735002273 NAD binding site [chemical binding]; other site 391735002274 dimerization interface [polypeptide binding]; other site 391735002275 product binding site; other site 391735002276 substrate binding site [chemical binding]; other site 391735002277 zinc binding site [ion binding]; other site 391735002278 catalytic residues [active] 391735002279 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735002280 NAD(P) binding site [chemical binding]; other site 391735002281 active site 391735002282 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 391735002283 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 391735002284 putative NAD(P) binding site [chemical binding]; other site 391735002285 catalytic Zn binding site [ion binding]; other site 391735002286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735002287 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391735002288 putative substrate translocation pore; other site 391735002289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735002290 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 391735002291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 391735002292 FeS/SAM binding site; other site 391735002293 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 391735002294 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 391735002295 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 391735002296 GTP binding site [chemical binding]; other site 391735002297 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 391735002298 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 391735002299 dimer interface [polypeptide binding]; other site 391735002300 putative functional site; other site 391735002301 putative MPT binding site; other site 391735002302 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 391735002303 catalytic residues [active] 391735002304 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391735002305 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391735002306 Predicted membrane protein [Function unknown]; Region: COG3748 391735002307 Protein of unknown function (DUF989); Region: DUF989; pfam06181 391735002308 Cytochrome c; Region: Cytochrom_C; cl11414 391735002309 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 391735002310 putative active site [active] 391735002311 catalytic triad [active] 391735002312 dimer interface [polypeptide binding]; other site 391735002313 hypothetical protein; Validated; Region: PRK06201 391735002314 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 391735002315 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735002316 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391735002317 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735002318 Walker A/P-loop; other site 391735002319 ATP binding site [chemical binding]; other site 391735002320 Q-loop/lid; other site 391735002321 ABC transporter signature motif; other site 391735002322 Walker B; other site 391735002323 D-loop; other site 391735002324 H-loop/switch region; other site 391735002325 TOBE domain; Region: TOBE_2; cl01440 391735002326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002327 dimer interface [polypeptide binding]; other site 391735002328 conserved gate region; other site 391735002329 putative PBP binding loops; other site 391735002330 ABC-ATPase subunit interface; other site 391735002331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002332 dimer interface [polypeptide binding]; other site 391735002333 conserved gate region; other site 391735002334 putative PBP binding loops; other site 391735002335 ABC-ATPase subunit interface; other site 391735002336 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735002337 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 391735002338 tetrameric interface [polypeptide binding]; other site 391735002339 NAD binding site [chemical binding]; other site 391735002340 catalytic residues [active] 391735002341 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735002342 substrate binding pocket [chemical binding]; other site 391735002343 membrane-bound complex binding site; other site 391735002344 hinge residues; other site 391735002345 thiamine pyrophosphate protein; Validated; Region: PRK08199 391735002346 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391735002347 PYR/PP interface [polypeptide binding]; other site 391735002348 dimer interface [polypeptide binding]; other site 391735002349 TPP binding site [chemical binding]; other site 391735002350 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391735002351 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 391735002352 TPP-binding site [chemical binding]; other site 391735002353 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 391735002354 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391735002355 PYR/PP interface [polypeptide binding]; other site 391735002356 dimer interface [polypeptide binding]; other site 391735002357 TPP binding site [chemical binding]; other site 391735002358 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391735002359 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 391735002360 TPP-binding site [chemical binding]; other site 391735002361 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391735002362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002363 dimer interface [polypeptide binding]; other site 391735002364 conserved gate region; other site 391735002365 putative PBP binding loops; other site 391735002366 ABC-ATPase subunit interface; other site 391735002367 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 391735002368 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735002369 substrate binding pocket [chemical binding]; other site 391735002370 membrane-bound complex binding site; other site 391735002371 hinge residues; other site 391735002372 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391735002373 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735002374 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391735002375 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391735002376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735002377 DNA-binding site [nucleotide binding]; DNA binding site 391735002378 FCD domain; Region: FCD; cl11656 391735002379 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 391735002380 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 391735002381 DNA repair protein RadA; Provisional; Region: PRK11823 391735002382 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 391735002383 Walker A motif/ATP binding site; other site 391735002384 ATP binding site [chemical binding]; other site 391735002385 Walker B motif; other site 391735002386 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 391735002387 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 391735002388 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 391735002389 substrate binding site [chemical binding]; other site 391735002390 ATP binding site [chemical binding]; other site 391735002391 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391735002392 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 391735002393 Walker A/P-loop; other site 391735002394 ATP binding site [chemical binding]; other site 391735002395 Q-loop/lid; other site 391735002396 ABC transporter signature motif; other site 391735002397 Walker B; other site 391735002398 D-loop; other site 391735002399 H-loop/switch region; other site 391735002400 TOBE domain; Region: TOBE_2; cl01440 391735002401 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 391735002402 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 391735002403 putative NAD(P) binding site [chemical binding]; other site 391735002404 catalytic Zn binding site [ion binding]; other site 391735002405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735002406 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391735002407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002408 dimer interface [polypeptide binding]; other site 391735002409 conserved gate region; other site 391735002410 putative PBP binding loops; other site 391735002411 ABC-ATPase subunit interface; other site 391735002412 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391735002413 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735002414 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391735002415 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391735002416 DNA binding site [nucleotide binding] 391735002417 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 391735002418 putative ligand binding site [chemical binding]; other site 391735002419 putative dimerization interface [polypeptide binding]; other site 391735002420 Uncharacterized conserved protein [Function unknown]; Region: COG4279 391735002421 malic enzyme; Reviewed; Region: PRK12862 391735002422 Malic enzyme, N-terminal domain; Region: malic; pfam00390 391735002423 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 391735002424 putative NAD(P) binding site [chemical binding]; other site 391735002425 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 391735002426 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 391735002427 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735002428 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735002429 Cytochrome c; Region: Cytochrom_C; cl11414 391735002430 Cytochrome c; Region: Cytochrom_C; cl11414 391735002431 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 391735002432 homotrimer interaction site [polypeptide binding]; other site 391735002433 putative active site [active] 391735002434 SNF2 Helicase protein; Region: DUF3670; pfam12419 391735002435 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 391735002436 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735002437 ATP binding site [chemical binding]; other site 391735002438 putative Mg++ binding site [ion binding]; other site 391735002439 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391735002440 nucleotide binding region [chemical binding]; other site 391735002441 ATP-binding site [chemical binding]; other site 391735002442 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 391735002443 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735002444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002445 dimer interface [polypeptide binding]; other site 391735002446 conserved gate region; other site 391735002447 putative PBP binding loops; other site 391735002448 ABC-ATPase subunit interface; other site 391735002449 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391735002450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002451 dimer interface [polypeptide binding]; other site 391735002452 conserved gate region; other site 391735002453 putative PBP binding loops; other site 391735002454 ABC-ATPase subunit interface; other site 391735002455 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735002456 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735002457 Walker A/P-loop; other site 391735002458 ATP binding site [chemical binding]; other site 391735002459 Q-loop/lid; other site 391735002460 ABC transporter signature motif; other site 391735002461 Walker B; other site 391735002462 D-loop; other site 391735002463 H-loop/switch region; other site 391735002464 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735002465 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735002466 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391735002467 Walker A/P-loop; other site 391735002468 ATP binding site [chemical binding]; other site 391735002469 Q-loop/lid; other site 391735002470 ABC transporter signature motif; other site 391735002471 Walker B; other site 391735002472 D-loop; other site 391735002473 H-loop/switch region; other site 391735002474 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735002475 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 391735002476 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735002477 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 391735002478 Predicted peptidase [General function prediction only]; Region: COG4099 391735002479 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735002480 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391735002481 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391735002482 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 391735002483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002484 dimer interface [polypeptide binding]; other site 391735002485 conserved gate region; other site 391735002486 putative PBP binding loops; other site 391735002487 ABC-ATPase subunit interface; other site 391735002488 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391735002489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002490 dimer interface [polypeptide binding]; other site 391735002491 conserved gate region; other site 391735002492 putative PBP binding loops; other site 391735002493 ABC-ATPase subunit interface; other site 391735002494 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 391735002495 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735002496 Walker A/P-loop; other site 391735002497 ATP binding site [chemical binding]; other site 391735002498 Q-loop/lid; other site 391735002499 ABC transporter signature motif; other site 391735002500 Walker B; other site 391735002501 D-loop; other site 391735002502 H-loop/switch region; other site 391735002503 TOBE domain; Region: TOBE_2; cl01440 391735002504 putative aminotransferase; Validated; Region: PRK07480 391735002505 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 391735002506 inhibitor-cofactor binding pocket; inhibition site 391735002507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735002508 catalytic residue [active] 391735002509 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391735002510 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391735002511 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735002512 FAD dependent oxidoreductase; Region: DAO; pfam01266 391735002513 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 391735002514 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 391735002515 carboxyltransferase (CT) interaction site; other site 391735002516 biotinylation site [posttranslational modification]; other site 391735002517 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 391735002518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735002519 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 391735002520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735002521 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735002522 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 391735002523 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735002524 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735002525 allophanate hydrolase; Provisional; Region: PRK08186 391735002526 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 391735002527 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 391735002528 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735002529 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391735002530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735002531 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391735002532 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 391735002533 Walker A/P-loop; other site 391735002534 ATP binding site [chemical binding]; other site 391735002535 Q-loop/lid; other site 391735002536 ABC transporter signature motif; other site 391735002537 Walker B; other site 391735002538 D-loop; other site 391735002539 H-loop/switch region; other site 391735002540 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 391735002541 putative ligand binding site [chemical binding]; other site 391735002542 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391735002543 TM-ABC transporter signature motif; other site 391735002544 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391735002545 TM-ABC transporter signature motif; other site 391735002546 Isochorismatase family; Region: Isochorismatase; pfam00857 391735002547 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 391735002548 catalytic triad [active] 391735002549 conserved cis-peptide bond; other site 391735002550 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391735002551 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735002552 Walker A/P-loop; other site 391735002553 ATP binding site [chemical binding]; other site 391735002554 Q-loop/lid; other site 391735002555 ABC transporter signature motif; other site 391735002556 Walker B; other site 391735002557 D-loop; other site 391735002558 H-loop/switch region; other site 391735002559 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735002560 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391735002561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735002562 DNA-binding site [nucleotide binding]; DNA binding site 391735002563 FCD domain; Region: FCD; cl11656 391735002564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735002565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735002566 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735002567 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 391735002568 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391735002569 putative NAD(P) binding site [chemical binding]; other site 391735002570 active site 391735002571 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 391735002572 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 391735002573 active site 391735002574 catalytic tetrad [active] 391735002575 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 391735002576 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391735002577 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735002578 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 391735002579 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 391735002580 carboxyltransferase (CT) interaction site; other site 391735002581 biotinylation site [posttranslational modification]; other site 391735002582 EamA-like transporter family; Region: EamA; cl01037 391735002583 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391735002584 EamA-like transporter family; Region: EamA; cl01037 391735002585 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735002586 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 391735002587 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cd01292 391735002588 active site 391735002589 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735002590 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 391735002591 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735002592 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391735002593 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 391735002594 FAD binding pocket [chemical binding]; other site 391735002595 FAD binding motif [chemical binding]; other site 391735002596 phosphate binding motif [ion binding]; other site 391735002597 beta-alpha-beta structure motif; other site 391735002598 NAD binding pocket [chemical binding]; other site 391735002599 ApbE family; Region: ApbE; cl00643 391735002600 Protein of unknown function (DUF1185); Region: DUF1185; pfam06684 391735002601 Protein of unknown function (DUF1185); Region: DUF1185; pfam06684 391735002602 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735002603 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 391735002604 putative ligand binding site [chemical binding]; other site 391735002605 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735002606 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735002607 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735002608 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735002609 TM-ABC transporter signature motif; other site 391735002610 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735002611 TM-ABC transporter signature motif; other site 391735002612 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735002613 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735002614 Walker A/P-loop; other site 391735002615 ATP binding site [chemical binding]; other site 391735002616 Q-loop/lid; other site 391735002617 ABC transporter signature motif; other site 391735002618 Walker B; other site 391735002619 D-loop; other site 391735002620 H-loop/switch region; other site 391735002621 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735002622 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735002623 Walker A/P-loop; other site 391735002624 ATP binding site [chemical binding]; other site 391735002625 Q-loop/lid; other site 391735002626 ABC transporter signature motif; other site 391735002627 Walker B; other site 391735002628 D-loop; other site 391735002629 H-loop/switch region; other site 391735002630 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 391735002631 Isochorismatase family; Region: Isochorismatase; pfam00857 391735002632 catalytic triad [active] 391735002633 metal binding site [ion binding]; metal-binding site 391735002634 conserved cis-peptide bond; other site 391735002635 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 391735002636 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 391735002637 dimer interface [polypeptide binding]; other site 391735002638 decamer (pentamer of dimers) interface [polypeptide binding]; other site 391735002639 catalytic triad [active] 391735002640 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735002641 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 391735002642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002643 dimer interface [polypeptide binding]; other site 391735002644 conserved gate region; other site 391735002645 putative PBP binding loops; other site 391735002646 ABC-ATPase subunit interface; other site 391735002647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002648 dimer interface [polypeptide binding]; other site 391735002649 conserved gate region; other site 391735002650 putative PBP binding loops; other site 391735002651 ABC-ATPase subunit interface; other site 391735002652 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 391735002653 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-...; Region: ABC_CysA_sulfate_importer; cd03296 391735002654 Walker A/P-loop; other site 391735002655 ATP binding site [chemical binding]; other site 391735002656 Q-loop/lid; other site 391735002657 ABC transporter signature motif; other site 391735002658 Walker B; other site 391735002659 D-loop; other site 391735002660 H-loop/switch region; other site 391735002661 TOBE-like domain; Region: TOBE_3; pfam12857 391735002662 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 391735002663 N-acetylglutamate synthase; Validated; Region: PRK05279 391735002664 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an N-...; Region: AAK_NAGS-ABP; cd04237 391735002665 putative feedback inhibition sensing region; other site 391735002666 putative nucleotide binding site [chemical binding]; other site 391735002667 putative substrate binding site [chemical binding]; other site 391735002668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391735002669 Coenzyme A binding pocket [chemical binding]; other site 391735002670 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 391735002671 Cupin domain; Region: Cupin_2; cl09118 391735002672 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391735002673 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 391735002674 conserved cys residue [active] 391735002675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391735002676 hypothetical protein; Provisional; Region: PRK07206 391735002677 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735002678 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 391735002679 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735002680 ATP binding site [chemical binding]; other site 391735002681 putative Mg++ binding site [ion binding]; other site 391735002682 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391735002683 nucleotide binding region [chemical binding]; other site 391735002684 ATP-binding site [chemical binding]; other site 391735002685 Helicase associated domain (HA2); Region: HA2; cl04503 391735002686 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 391735002687 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 391735002688 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 391735002689 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735002690 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735002691 substrate binding site [chemical binding]; other site 391735002692 oxyanion hole (OAH) forming residues; other site 391735002693 trimer interface [polypeptide binding]; other site 391735002694 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735002695 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735002696 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735002697 active site 391735002698 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 391735002699 Coenzyme A transferase; Region: CoA_trans; cl00773 391735002700 Coenzyme A transferase; Region: CoA_trans; cl00773 391735002701 choline dehydrogenase; Validated; Region: PRK02106 391735002702 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391735002703 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391735002704 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391735002705 ligand binding site [chemical binding]; other site 391735002706 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735002707 TM-ABC transporter signature motif; other site 391735002708 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735002709 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735002710 Walker A/P-loop; other site 391735002711 ATP binding site [chemical binding]; other site 391735002712 Q-loop/lid; other site 391735002713 ABC transporter signature motif; other site 391735002714 Walker B; other site 391735002715 D-loop; other site 391735002716 H-loop/switch region; other site 391735002717 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735002718 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735002719 TM-ABC transporter signature motif; other site 391735002720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735002721 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735002722 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 391735002723 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 391735002724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735002725 SAF domain; Region: SAF; cl00555 391735002726 SAF domain; Region: SAF; cl00555 391735002727 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391735002728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735002729 DNA-binding site [nucleotide binding]; DNA binding site 391735002730 UTRA domain; Region: UTRA; cl06649 391735002731 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735002732 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 391735002733 putative ligand binding site [chemical binding]; other site 391735002734 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735002735 TM-ABC transporter signature motif; other site 391735002736 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735002737 TM-ABC transporter signature motif; other site 391735002738 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735002739 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735002740 Walker A/P-loop; other site 391735002741 ATP binding site [chemical binding]; other site 391735002742 Q-loop/lid; other site 391735002743 ABC transporter signature motif; other site 391735002744 Walker B; other site 391735002745 D-loop; other site 391735002746 H-loop/switch region; other site 391735002747 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735002748 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735002749 Walker A/P-loop; other site 391735002750 ATP binding site [chemical binding]; other site 391735002751 Q-loop/lid; other site 391735002752 ABC transporter signature motif; other site 391735002753 Walker B; other site 391735002754 D-loop; other site 391735002755 H-loop/switch region; other site 391735002756 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 391735002757 TPP-binding site [chemical binding]; other site 391735002758 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 391735002759 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391735002760 PYR/PP interface [polypeptide binding]; other site 391735002761 dimer interface [polypeptide binding]; other site 391735002762 TPP binding site [chemical binding]; other site 391735002763 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391735002764 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 391735002765 dimer interface [polypeptide binding]; other site 391735002766 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 391735002767 active site 391735002768 metal binding site [ion binding]; metal-binding site 391735002769 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 391735002770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735002771 NAD(P) binding site [chemical binding]; other site 391735002772 active site 391735002773 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 391735002774 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735002775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735002776 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 391735002777 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735002778 Bacterial transcriptional regulator; Region: IclR; pfam01614 391735002779 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 391735002780 active site 391735002781 catalytic site [active] 391735002782 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 391735002783 active site 391735002784 catalytic site [active] 391735002785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735002786 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735002787 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 391735002788 ADP-ribose binding site [chemical binding]; other site 391735002789 choline dehydrogenase; Validated; Region: PRK02106 391735002790 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391735002791 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 391735002792 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 391735002793 active site 391735002794 catalytic residues [active] 391735002795 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391735002796 classical (c) SDRs; Region: SDR_c; cd05233 391735002797 NAD(P) binding site [chemical binding]; other site 391735002798 active site 391735002799 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735002800 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735002801 Walker A/P-loop; other site 391735002802 ATP binding site [chemical binding]; other site 391735002803 Q-loop/lid; other site 391735002804 ABC transporter signature motif; other site 391735002805 Walker B; other site 391735002806 D-loop; other site 391735002807 H-loop/switch region; other site 391735002808 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735002809 TM-ABC transporter signature motif; other site 391735002810 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391735002811 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 391735002812 putative ligand binding site [chemical binding]; other site 391735002813 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391735002814 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues...; Region: MR_like; cd03316 391735002815 active site pocket [active] 391735002816 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391735002817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735002818 DNA-binding site [nucleotide binding]; DNA binding site 391735002819 FCD domain; Region: FCD; cl11656 391735002820 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 391735002821 Domain of unknown function DUF140; Region: DUF140; cl00510 391735002822 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 391735002823 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 391735002824 Walker A/P-loop; other site 391735002825 ATP binding site [chemical binding]; other site 391735002826 Q-loop/lid; other site 391735002827 ABC transporter signature motif; other site 391735002828 Walker B; other site 391735002829 D-loop; other site 391735002830 H-loop/switch region; other site 391735002831 mce related protein; Region: MCE; cl03606 391735002832 Protein of unknown function (DUF330); Region: DUF330; cl01135 391735002833 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 391735002834 EamA-like transporter family; Region: EamA; cl01037 391735002835 glutathione synthetase; Provisional; Region: PRK05246 391735002836 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 391735002837 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735002838 Sulfate transporter family; Region: Sulfate_transp; cl00967 391735002839 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 391735002840 MOFRL family; Region: MOFRL; cl01013 391735002841 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 391735002842 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391735002843 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 391735002844 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 391735002845 DNA binding residues [nucleotide binding] 391735002846 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995 391735002847 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 391735002848 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 391735002849 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 391735002850 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 391735002851 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 391735002852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735002853 putative substrate translocation pore; other site 391735002854 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391735002855 Sulfatase; Region: Sulfatase; cl10460 391735002856 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391735002857 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735002858 Walker A/P-loop; other site 391735002859 ATP binding site [chemical binding]; other site 391735002860 Q-loop/lid; other site 391735002861 ABC transporter signature motif; other site 391735002862 Walker B; other site 391735002863 D-loop; other site 391735002864 H-loop/switch region; other site 391735002865 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735002866 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735002867 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735002868 Walker A/P-loop; other site 391735002869 ATP binding site [chemical binding]; other site 391735002870 Q-loop/lid; other site 391735002871 ABC transporter signature motif; other site 391735002872 Walker B; other site 391735002873 D-loop; other site 391735002874 H-loop/switch region; other site 391735002875 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735002876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002877 dimer interface [polypeptide binding]; other site 391735002878 conserved gate region; other site 391735002879 putative PBP binding loops; other site 391735002880 ABC-ATPase subunit interface; other site 391735002881 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735002882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002883 dimer interface [polypeptide binding]; other site 391735002884 conserved gate region; other site 391735002885 putative PBP binding loops; other site 391735002886 ABC-ATPase subunit interface; other site 391735002887 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 391735002888 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735002889 Dehydratase family; Region: ILVD_EDD; cl00340 391735002890 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 391735002891 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735002892 classical (c) SDRs; Region: SDR_c; cd05233 391735002893 NAD(P) binding site [chemical binding]; other site 391735002894 active site 391735002895 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 391735002896 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 391735002897 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 391735002898 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 391735002899 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391735002900 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735002901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002902 dimer interface [polypeptide binding]; other site 391735002903 conserved gate region; other site 391735002904 putative PBP binding loops; other site 391735002905 ABC-ATPase subunit interface; other site 391735002906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002907 dimer interface [polypeptide binding]; other site 391735002908 conserved gate region; other site 391735002909 putative PBP binding loops; other site 391735002910 ABC-ATPase subunit interface; other site 391735002911 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391735002912 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 391735002913 Walker A/P-loop; other site 391735002914 ATP binding site [chemical binding]; other site 391735002915 Q-loop/lid; other site 391735002916 ABC transporter signature motif; other site 391735002917 Walker B; other site 391735002918 D-loop; other site 391735002919 H-loop/switch region; other site 391735002920 TOBE domain; Region: TOBE_2; cl01440 391735002921 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391735002922 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391735002923 DNA binding site [nucleotide binding] 391735002924 domain linker motif; other site 391735002925 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 391735002926 putative dimerization interface [polypeptide binding]; other site 391735002927 putative ligand binding site [chemical binding]; other site 391735002928 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 391735002929 putative active site [active] 391735002930 catalytic residue [active] 391735002931 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 391735002932 5S rRNA interface [nucleotide binding]; other site 391735002933 CTC domain interface; other site 391735002934 L16 interface [polypeptide binding]; other site 391735002935 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923 391735002936 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 391735002937 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 391735002938 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 391735002939 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 391735002940 binding surface 391735002941 TPR motif; other site 391735002942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 391735002943 binding surface 391735002944 TPR motif; other site 391735002945 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 391735002946 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 391735002947 DNA binding site [nucleotide binding] 391735002948 catalytic residue [active] 391735002949 H2TH interface [polypeptide binding]; other site 391735002950 putative catalytic residues [active] 391735002951 turnover-facilitating residue; other site 391735002952 intercalation triad [nucleotide binding]; other site 391735002953 8OG recognition residue [nucleotide binding]; other site 391735002954 putative reading head residues; other site 391735002955 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 391735002956 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 391735002957 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391735002958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735002959 NAD(P) binding site [chemical binding]; other site 391735002960 active site 391735002961 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 391735002962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735002963 putative substrate translocation pore; other site 391735002964 FAD binding domain; Region: FAD_binding_4; pfam01565 391735002965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391735002966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735002967 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391735002968 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735002969 DNA-binding site [nucleotide binding]; DNA binding site 391735002970 FCD domain; Region: FCD; cl11656 391735002971 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 391735002972 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 391735002973 putative catalytic cysteine [active] 391735002974 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 391735002975 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 391735002976 Arginase family; Region: Arginase; cl00306 391735002977 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735002978 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735002979 catalytic residue [active] 391735002980 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 391735002981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735002982 dimer interface [polypeptide binding]; other site 391735002983 conserved gate region; other site 391735002984 putative PBP binding loops; other site 391735002985 ABC-ATPase subunit interface; other site 391735002986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735002987 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 391735002988 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735002989 Walker A/P-loop; other site 391735002990 ATP binding site [chemical binding]; other site 391735002991 Q-loop/lid; other site 391735002992 ABC transporter signature motif; other site 391735002993 Walker B; other site 391735002994 D-loop; other site 391735002995 H-loop/switch region; other site 391735002996 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 391735002997 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735002998 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735002999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735003000 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735003001 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391735003002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735003003 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735003004 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735003005 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 391735003006 Ferritin-like domain; Region: Ferritin; pfam00210 391735003007 heme binding site [chemical binding]; other site 391735003008 ferroxidase pore; other site 391735003009 ferroxidase diiron center [ion binding]; other site 391735003010 chaperone protein DnaJ; Provisional; Region: PRK10767 391735003011 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 391735003012 HSP70 interaction site [polypeptide binding]; other site 391735003013 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 391735003014 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 391735003015 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 391735003016 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 391735003017 dimer interface [polypeptide binding]; other site 391735003018 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 391735003019 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 391735003020 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 391735003021 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 391735003022 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 391735003023 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 391735003024 replicative DNA helicase; Region: DnaB; TIGR00665 391735003025 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 391735003026 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 391735003027 Walker A motif; other site 391735003028 ATP binding site [chemical binding]; other site 391735003029 Walker B motif; other site 391735003030 DNA binding loops [nucleotide binding] 391735003031 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 391735003032 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 391735003033 putative active site [active] 391735003034 PhoH-like protein; Region: PhoH; cl12134 391735003035 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 391735003036 catalytic triad [active] 391735003037 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 391735003038 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 391735003039 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 391735003040 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391735003041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735003042 DNA-binding site [nucleotide binding]; DNA binding site 391735003043 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735003044 DNA-binding site [nucleotide binding]; DNA binding site 391735003045 FCD domain; Region: FCD; cl11656 391735003046 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391735003047 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735003048 Walker A/P-loop; other site 391735003049 ATP binding site [chemical binding]; other site 391735003050 Q-loop/lid; other site 391735003051 ABC transporter signature motif; other site 391735003052 Walker B; other site 391735003053 D-loop; other site 391735003054 H-loop/switch region; other site 391735003055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735003056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735003057 putative PBP binding loops; other site 391735003058 dimer interface [polypeptide binding]; other site 391735003059 ABC-ATPase subunit interface; other site 391735003060 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735003061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735003062 NAD(P) binding site [chemical binding]; other site 391735003063 active site 391735003064 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735003065 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 391735003066 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735003067 Walker A/P-loop; other site 391735003068 ATP binding site [chemical binding]; other site 391735003069 Q-loop/lid; other site 391735003070 ABC transporter signature motif; other site 391735003071 Walker B; other site 391735003072 D-loop; other site 391735003073 H-loop/switch region; other site 391735003074 TOBE domain; Region: TOBE_2; cl01440 391735003075 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 391735003076 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 391735003077 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 391735003078 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 391735003079 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 391735003080 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391735003081 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 391735003082 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 391735003083 YceG-like family; Region: YceG; pfam02618 391735003084 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 391735003085 dimerization interface [polypeptide binding]; other site 391735003086 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 391735003087 TMP-binding site; other site 391735003088 ATP-binding site [chemical binding]; other site 391735003089 DNA polymerase III subunit delta'; Validated; Region: PRK06964 391735003090 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735003091 PilZ domain; Region: PilZ; cl01260 391735003092 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 391735003093 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 391735003094 active site 391735003095 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 391735003096 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 391735003097 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 391735003098 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 391735003099 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 391735003100 Walker A/P-loop; other site 391735003101 ATP binding site [chemical binding]; other site 391735003102 Q-loop/lid; other site 391735003103 ABC transporter signature motif; other site 391735003104 Walker B; other site 391735003105 D-loop; other site 391735003106 H-loop/switch region; other site 391735003107 translocation protein TolB; Provisional; Region: tolB; PRK02889 391735003108 TolB amino-terminal domain; Region: TolB_N; pfam04052 391735003109 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391735003110 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391735003111 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391735003112 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391735003113 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391735003114 ligand binding site [chemical binding]; other site 391735003115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 391735003116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735003117 ATP binding site [chemical binding]; other site 391735003118 substrate interface [chemical binding]; other site 391735003119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735003120 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 391735003121 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 391735003122 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 391735003123 HsdM N-terminal domain; Region: HsdM_N; pfam12161 391735003124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735003125 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 391735003126 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735003127 ATP binding site [chemical binding]; other site 391735003128 putative Mg++ binding site [ion binding]; other site 391735003129 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 391735003130 Putative exonuclease, RdgC; Region: RdgC; cl01122 391735003131 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 391735003132 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 391735003133 cysteine synthases; Region: cysKM; TIGR01136 391735003134 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 391735003135 dimer interface [polypeptide binding]; other site 391735003136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735003137 catalytic residue [active] 391735003138 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 391735003139 nudix motif; other site 391735003140 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 391735003141 CPxP motif; other site 391735003142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735003143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735003144 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735003145 dimerization interface [polypeptide binding]; other site 391735003146 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391735003147 Sulfatase; Region: Sulfatase; cl10460 391735003148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735003149 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735003150 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391735003151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735003152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735003153 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 391735003154 active site 391735003155 tetramer interface [polypeptide binding]; other site 391735003156 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 391735003157 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391735003158 active site 391735003159 HIGH motif; other site 391735003160 nucleotide binding site [chemical binding]; other site 391735003161 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 391735003162 active site 391735003163 KMSKS motif; other site 391735003164 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 391735003165 tRNA binding surface [nucleotide binding]; other site 391735003166 anticodon binding site; other site 391735003167 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 391735003168 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 391735003169 Zn binding site [ion binding]; other site 391735003170 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 391735003171 HemX; Region: HemX; cl14667 391735003172 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 391735003173 active site 391735003174 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 391735003175 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 391735003176 domain interfaces; other site 391735003177 active site 391735003178 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 391735003179 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 391735003180 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 391735003181 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 391735003182 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 391735003183 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 391735003184 RNA binding site [nucleotide binding]; other site 391735003185 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 391735003186 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 391735003187 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 391735003188 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735003189 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 391735003190 dimerization interface [polypeptide binding]; other site 391735003191 ligand binding site [chemical binding]; other site 391735003192 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 391735003193 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 391735003194 inhibitor site; inhibition site 391735003195 active site 391735003196 dimer interface [polypeptide binding]; other site 391735003197 catalytic residue [active] 391735003198 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 391735003199 isocitrate dehydrogenase; Validated; Region: PRK06451 391735003200 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 391735003201 substrate binding site [chemical binding]; other site 391735003202 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 391735003203 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 391735003204 substrate binding site [chemical binding]; other site 391735003205 ligand binding site [chemical binding]; other site 391735003206 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 391735003207 HrcA protein C terminal domain; Region: HrcA; pfam01628 391735003208 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 391735003209 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 391735003210 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 391735003211 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 391735003212 Walker A/P-loop; other site 391735003213 ATP binding site [chemical binding]; other site 391735003214 Q-loop/lid; other site 391735003215 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 391735003216 ABC transporter signature motif; other site 391735003217 Walker B; other site 391735003218 D-loop; other site 391735003219 H-loop/switch region; other site 391735003220 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 391735003221 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 391735003222 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391735003223 minor groove reading motif; other site 391735003224 helix-hairpin-helix signature motif; other site 391735003225 substrate binding pocket [chemical binding]; other site 391735003226 active site 391735003227 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 391735003228 DNA binding and oxoG recognition site [nucleotide binding] 391735003229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735003230 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735003231 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735003232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735003233 putative substrate translocation pore; other site 391735003234 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 391735003235 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391735003236 metal-binding site [ion binding] 391735003237 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391735003238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 391735003239 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 391735003240 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 391735003241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735003242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 391735003243 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 391735003244 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 391735003245 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 391735003246 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 391735003247 LysE type translocator; Region: LysE; cl00565 391735003248 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 391735003249 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 391735003250 P-loop; other site 391735003251 Magnesium ion binding site [ion binding]; other site 391735003252 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 391735003253 Magnesium ion binding site [ion binding]; other site 391735003254 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735003255 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 391735003256 ParB-like nuclease domain; Region: ParBc; cl02129 391735003257 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 391735003258 dihydrodipicolinate reductase; Provisional; Region: PRK00048 391735003259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735003260 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 391735003261 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 391735003262 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 391735003263 HIGH motif; other site 391735003264 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391735003265 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391735003266 active site 391735003267 KMSKS motif; other site 391735003268 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 391735003269 tRNA binding surface [nucleotide binding]; other site 391735003270 Lipopolysaccharide-assembly; Region: LptE; cl01125 391735003271 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 391735003272 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 391735003273 active site 391735003274 dimer interface [polypeptide binding]; other site 391735003275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735003276 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735003277 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 391735003278 active site 391735003279 Zn-binding site [ion binding]; other site 391735003280 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 391735003281 ScpA/B protein; Region: ScpA_ScpB; cl00598 391735003282 L-aspartate oxidase; Provisional; Region: PRK09077 391735003283 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735003284 domain; Region: Succ_DH_flav_C; pfam02910 391735003285 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 391735003286 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 391735003287 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 391735003288 active site 391735003289 purine riboside binding site [chemical binding]; other site 391735003290 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391735003291 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 391735003292 putative active site pocket [active] 391735003293 metal binding site [ion binding]; metal-binding site 391735003294 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 391735003295 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391735003296 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 391735003297 putative ligand binding site [chemical binding]; other site 391735003298 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735003299 TM-ABC transporter signature motif; other site 391735003300 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735003301 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735003302 Walker A/P-loop; other site 391735003303 ATP binding site [chemical binding]; other site 391735003304 Q-loop/lid; other site 391735003305 ABC transporter signature motif; other site 391735003306 Walker B; other site 391735003307 D-loop; other site 391735003308 H-loop/switch region; other site 391735003309 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735003310 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391735003311 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 391735003312 NAD binding site [chemical binding]; other site 391735003313 homotetramer interface [polypeptide binding]; other site 391735003314 homodimer interface [polypeptide binding]; other site 391735003315 active site 391735003316 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735003317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735003318 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 391735003319 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974 391735003320 catalytic residue [active] 391735003321 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 391735003322 catalytic residues [active] 391735003323 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735003324 peroxiredoxin; Region: AhpC; TIGR03137 391735003325 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 391735003326 dimer interface [polypeptide binding]; other site 391735003327 decamer (pentamer of dimers) interface [polypeptide binding]; other site 391735003328 catalytic triad [active] 391735003329 peroxidatic and resolving cysteines [active] 391735003330 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 391735003331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735003332 DNA-binding site [nucleotide binding]; DNA binding site 391735003333 FCD domain; Region: FCD; cl11656 391735003334 Sulfatase; Region: Sulfatase; cl10460 391735003335 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735003336 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 391735003337 NAD(P) binding site [chemical binding]; other site 391735003338 catalytic residues [active] 391735003339 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl14899 391735003340 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 391735003341 EamA-like transporter family; Region: EamA; cl01037 391735003342 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 391735003343 OPT oligopeptide transporter protein; Region: OPT; cl14607 391735003344 OPT oligopeptide transporter protein; Region: OPT; cl14607 391735003345 High-affinity nickel-transport protein; Region: NicO; cl00964 391735003346 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735003347 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391735003348 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391735003349 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 391735003350 Walker A/P-loop; other site 391735003351 ATP binding site [chemical binding]; other site 391735003352 Q-loop/lid; other site 391735003353 ABC transporter signature motif; other site 391735003354 Walker B; other site 391735003355 D-loop; other site 391735003356 H-loop/switch region; other site 391735003357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735003358 dimer interface [polypeptide binding]; other site 391735003359 conserved gate region; other site 391735003360 putative PBP binding loops; other site 391735003361 ABC-ATPase subunit interface; other site 391735003362 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391735003363 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735003364 Flagellar protein FliS; Region: FliS; cl00654 391735003365 Flagellar protein FliT; Region: FliT; cl05125 391735003366 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 391735003367 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 391735003368 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 391735003369 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 391735003370 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 391735003371 FliG C-terminal domain; Region: FliG_C; pfam01706 391735003372 flagellar assembly protein H; Validated; Region: fliH; PRK05687 391735003373 Flagellar assembly protein FliH; Region: FliH; pfam02108 391735003374 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 391735003375 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 391735003376 Walker A motif/ATP binding site; other site 391735003377 Walker B motif; other site 391735003378 Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669 391735003379 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 391735003380 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 391735003381 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 391735003382 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 391735003383 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 391735003384 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 391735003385 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 391735003386 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 391735003387 oligomeric interface; other site 391735003388 putative active site [active] 391735003389 homodimer interface [polypeptide binding]; other site 391735003390 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 391735003391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735003392 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735003393 enoyl-CoA hydratase; Provisional; Region: PRK06688 391735003394 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735003395 substrate binding site [chemical binding]; other site 391735003396 oxyanion hole (OAH) forming residues; other site 391735003397 trimer interface [polypeptide binding]; other site 391735003398 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 391735003399 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735003400 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735003401 active site 391735003402 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735003403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735003404 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735003405 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 391735003406 catalytic residues [active] 391735003407 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 391735003408 catalytic residues [active] 391735003409 galactarate dehydratase; Region: galactar-dH20; TIGR03248 391735003410 SAF domain; Region: SAF; cl00555 391735003411 SAF domain; Region: SAF; cl00555 391735003412 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735003413 enoyl-CoA hydratase; Region: PLN02600 391735003414 substrate binding site [chemical binding]; other site 391735003415 oxyanion hole (OAH) forming residues; other site 391735003416 trimer interface [polypeptide binding]; other site 391735003417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735003418 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735003419 ABC-2 type transporter; Region: ABC2_membrane; cl11417 391735003420 nodulation ABC transporter NodI; Provisional; Region: PRK13537 391735003421 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 391735003422 Walker A/P-loop; other site 391735003423 ATP binding site [chemical binding]; other site 391735003424 Q-loop/lid; other site 391735003425 ABC transporter signature motif; other site 391735003426 Walker B; other site 391735003427 D-loop; other site 391735003428 H-loop/switch region; other site 391735003429 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 391735003430 domain; Region: GreA_GreB_N; pfam03449 391735003431 C-term; Region: GreA_GreB; pfam01272 391735003432 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 391735003433 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391735003434 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735003435 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 391735003436 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391735003437 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735003438 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 391735003439 IMP binding site; other site 391735003440 dimer interface [polypeptide binding]; other site 391735003441 interdomain contacts; other site 391735003442 partial ornithine binding site; other site 391735003443 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 391735003444 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 391735003445 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 391735003446 catalytic site [active] 391735003447 subunit interface [polypeptide binding]; other site 391735003448 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-...; Region: FBPase; cd00354 391735003449 AMP binding site [chemical binding]; other site 391735003450 metal binding site [ion binding]; metal-binding site 391735003451 active site 391735003452 aminopeptidase N; Provisional; Region: pepN; PRK14015 391735003453 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 391735003454 Zn binding site [ion binding]; other site 391735003455 peptide chain release factor 2; Validated; Region: prfB; PRK00578 391735003456 RF-1 domain; Region: RF-1; cl02875 391735003457 RF-1 domain; Region: RF-1; cl02875 391735003458 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391735003459 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735003460 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391735003461 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 391735003462 AMP nucleosidase; Provisional; Region: PRK08292 391735003463 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 391735003464 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 391735003465 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 391735003466 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 391735003467 ATP binding site [chemical binding]; other site 391735003468 Mg++ binding site [ion binding]; other site 391735003469 motif III; other site 391735003470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391735003471 nucleotide binding region [chemical binding]; other site 391735003472 ATP-binding site [chemical binding]; other site 391735003473 DbpA RNA binding domain; Region: DbpA; pfam03880 391735003474 YaeQ protein; Region: YaeQ; cl01913 391735003475 adenylosuccinate lyase; Provisional; Region: PRK09285 391735003476 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 391735003477 tetramer interface [polypeptide binding]; other site 391735003478 putative glutathione S-transferase; Provisional; Region: PRK10357 391735003479 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 391735003480 putative C-terminal domain interface [polypeptide binding]; other site 391735003481 putative GSH binding site (G-site) [chemical binding]; other site 391735003482 putative dimer interface [polypeptide binding]; other site 391735003483 GST_C family, unknown subfamily 6; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_6; cd03205 391735003484 putative N-terminal domain interface [polypeptide binding]; other site 391735003485 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 391735003486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 391735003487 FeS/SAM binding site; other site 391735003488 HemN C-terminal region; Region: HemN_C; pfam06969 391735003489 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 391735003490 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391735003491 ligand binding site [chemical binding]; other site 391735003492 flexible hinge region; other site 391735003493 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391735003494 putative switch regulator; other site 391735003495 non-specific DNA interactions [nucleotide binding]; other site 391735003496 DNA binding site [nucleotide binding] 391735003497 sequence specific DNA binding site [nucleotide binding]; other site 391735003498 putative cAMP binding site [chemical binding]; other site 391735003499 FixH; Region: FixH; cl01254 391735003500 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 391735003501 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 391735003502 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 391735003503 Cytochrome c; Region: Cytochrom_C; cl11414 391735003504 Cytochrome c; Region: Cytochrom_C; cl11414 391735003505 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of...; Region: cbb3_Oxidase_CcoQ; cl00282 391735003506 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 391735003507 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the...; Region: cbb3_Oxidase_I; cd01661 391735003508 Low-spin heme binding site [chemical binding]; other site 391735003509 Putative water exit pathway; other site 391735003510 Binuclear center (active site) [active] 391735003511 Putative proton exit pathway; other site 391735003512 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 391735003513 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391735003514 metal-binding site [ion binding] 391735003515 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391735003516 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 391735003517 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391735003518 Ligand Binding Site [chemical binding]; other site 391735003519 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391735003520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735003521 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 391735003522 cofactor binding site; other site 391735003523 DNA binding site [nucleotide binding] 391735003524 substrate interaction site [chemical binding]; other site 391735003525 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 391735003526 additional DNA contacts [nucleotide binding]; other site 391735003527 mismatch recognition site; other site 391735003528 active site 391735003529 zinc binding site [ion binding]; other site 391735003530 DNA intercalation site [nucleotide binding]; other site 391735003531 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 391735003532 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735003533 ATP binding site [chemical binding]; other site 391735003534 putative Mg++ binding site [ion binding]; other site 391735003535 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391735003536 nucleotide binding region [chemical binding]; other site 391735003537 ATP-binding site [chemical binding]; other site 391735003538 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 391735003539 Uncharacterized conserved protein [Function unknown]; Region: COG3410 391735003540 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 391735003541 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 391735003542 putative active site [active] 391735003543 putative NTP binding site [chemical binding]; other site 391735003544 putative nucleic acid binding site [nucleotide binding]; other site 391735003545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 391735003546 Protein of unknown function (DUF1016); Region: DUF1016; cl01979 391735003547 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 391735003548 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 391735003549 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl14899 391735003550 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 391735003551 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 391735003552 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 391735003553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735003554 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735003555 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 391735003556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735003557 putative protease; Provisional; Region: PRK15452 391735003558 Peptidase family U32; Region: Peptidase_U32; cl03113 391735003559 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 391735003560 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 391735003561 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 391735003562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735003563 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_2; cd08448 391735003564 putative dimerization interface [polypeptide binding]; other site 391735003565 putative substrate binding pocket [chemical binding]; other site 391735003566 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735003567 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 391735003568 active site 391735003569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735003570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735003571 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 391735003572 dihydrodipicolinate synthase; Region: dapA; TIGR00674 391735003573 dimer interface [polypeptide binding]; other site 391735003574 active site 391735003575 catalytic residue [active] 391735003576 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 391735003577 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 391735003578 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 391735003579 metal binding site [ion binding]; metal-binding site 391735003580 putative dimer interface [polypeptide binding]; other site 391735003581 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391735003582 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 391735003583 putative C-terminal domain interface [polypeptide binding]; other site 391735003584 putative GSH binding site (G-site) [chemical binding]; other site 391735003585 putative dimer interface [polypeptide binding]; other site 391735003586 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cl02776 391735003587 substrate binding pocket (H-site) [chemical binding]; other site 391735003588 N-terminal domain interface [polypeptide binding]; other site 391735003589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 391735003590 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 391735003591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735003592 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 391735003593 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 391735003594 dimer interface [polypeptide binding]; other site 391735003595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735003596 catalytic residue [active] 391735003597 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 391735003598 active site 391735003599 ribulose/triose binding site [chemical binding]; other site 391735003600 phosphate binding site [ion binding]; other site 391735003601 substrate (anthranilate) binding pocket [chemical binding]; other site 391735003602 product (indole) binding pocket [chemical binding]; other site 391735003603 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 391735003604 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 391735003605 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 391735003606 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 391735003607 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 391735003608 glutamine binding [chemical binding]; other site 391735003609 catalytic triad [active] 391735003610 anthranilate synthase component I; Provisional; Region: PRK13565 391735003611 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 391735003612 chorismate binding enzyme; Region: Chorismate_bind; cl10555 391735003613 Peptidase family M48; Region: Peptidase_M48; cl12018 391735003614 Dihydroorotase [Nucleotide transport and metabolism]; Region: PyrC; COG0418 391735003615 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 391735003616 active site 391735003617 substrate binding pocket [chemical binding]; other site 391735003618 dimer interface [polypeptide binding]; other site 391735003619 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391735003620 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 391735003621 Walker A/P-loop; other site 391735003622 ATP binding site [chemical binding]; other site 391735003623 Q-loop/lid; other site 391735003624 ABC transporter signature motif; other site 391735003625 Walker B; other site 391735003626 D-loop; other site 391735003627 H-loop/switch region; other site 391735003628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735003629 dimer interface [polypeptide binding]; other site 391735003630 conserved gate region; other site 391735003631 putative PBP binding loops; other site 391735003632 ABC-ATPase subunit interface; other site 391735003633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735003634 dimer interface [polypeptide binding]; other site 391735003635 conserved gate region; other site 391735003636 putative PBP binding loops; other site 391735003637 ABC-ATPase subunit interface; other site 391735003638 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391735003639 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735003640 substrate binding pocket [chemical binding]; other site 391735003641 membrane-bound complex binding site; other site 391735003642 hinge residues; other site 391735003643 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 391735003644 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735003645 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 391735003646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735003647 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735003648 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 391735003649 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735003650 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 391735003651 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 391735003652 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735003653 active site 391735003654 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 391735003655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391735003656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735003657 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 391735003658 feedback inhibition sensing region; other site 391735003659 homohexameric interface [polypeptide binding]; other site 391735003660 nucleotide binding site [chemical binding]; other site 391735003661 N-acetyl-L-glutamate binding site [chemical binding]; other site 391735003662 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases...; Region: GT_MraY_like; cd06912 391735003663 Mg++ binding site [ion binding]; other site 391735003664 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 391735003665 putative catalytic motif [active] 391735003666 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391735003667 active site 391735003668 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 391735003669 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 391735003670 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 391735003671 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 391735003672 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735003673 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 391735003674 active site 391735003675 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 391735003676 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 391735003677 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 391735003678 extended (e) SDRs; Region: SDR_e; cd08946 391735003679 NAD(P) binding site [chemical binding]; other site 391735003680 active site 391735003681 substrate binding site [chemical binding]; other site 391735003682 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391735003683 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 391735003684 Walker A/P-loop; other site 391735003685 ATP binding site [chemical binding]; other site 391735003686 Q-loop/lid; other site 391735003687 ABC transporter signature motif; other site 391735003688 Walker B; other site 391735003689 D-loop; other site 391735003690 H-loop/switch region; other site 391735003691 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391735003692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735003693 dimer interface [polypeptide binding]; other site 391735003694 conserved gate region; other site 391735003695 putative PBP binding loops; other site 391735003696 ABC-ATPase subunit interface; other site 391735003697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735003698 dimer interface [polypeptide binding]; other site 391735003699 conserved gate region; other site 391735003700 putative PBP binding loops; other site 391735003701 ABC-ATPase subunit interface; other site 391735003702 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391735003703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735003704 GMP synthase; Reviewed; Region: guaA; PRK00074 391735003705 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 391735003706 AMP/PPi binding site [chemical binding]; other site 391735003707 candidate oxyanion hole; other site 391735003708 catalytic triad [active] 391735003709 potential glutamine specificity residues [chemical binding]; other site 391735003710 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 391735003711 ATP Binding subdomain [chemical binding]; other site 391735003712 Ligand Binding sites [chemical binding]; other site 391735003713 Dimerization subdomain; other site 391735003714 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 391735003715 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 391735003716 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 391735003717 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 391735003718 active site 391735003719 allantoate amidohydrolase; Reviewed; Region: PRK09290 391735003720 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 391735003721 active site 391735003722 metal binding site [ion binding]; metal-binding site 391735003723 dimer interface [polypeptide binding]; other site 391735003724 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391735003725 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved...; Region: MR_like_1; cd03326 391735003726 putative active site pocket [active] 391735003727 metal binding site [ion binding]; metal-binding site 391735003728 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 391735003729 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 391735003730 inhibitor-cofactor binding pocket; inhibition site 391735003731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735003732 catalytic residue [active] 391735003733 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735003734 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 391735003735 NAD(P) binding site [chemical binding]; other site 391735003736 catalytic residues [active] 391735003737 metabolite-proton symporter; Region: 2A0106; TIGR00883 391735003738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735003739 putative substrate translocation pore; other site 391735003740 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 391735003741 Glutamate-cysteine ligase; Region: GshA; pfam08886 391735003742 K+ potassium transporter; Region: K_trans; cl01227 391735003743 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 391735003744 Beta-lactamase; Region: Beta-lactamase; cl01009 391735003745 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 391735003746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735003747 DNA-binding site [nucleotide binding]; DNA binding site 391735003748 FCD domain; Region: FCD; cl11656 391735003749 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 391735003750 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735003751 substrate binding site [chemical binding]; other site 391735003752 oxyanion hole (OAH) forming residues; other site 391735003753 trimer interface [polypeptide binding]; other site 391735003754 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735003755 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735003756 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 391735003757 S17 interaction site [polypeptide binding]; other site 391735003758 S8 interaction site; other site 391735003759 16S rRNA interaction site [nucleotide binding]; other site 391735003760 streptomycin interaction site [chemical binding]; other site 391735003761 23S rRNA interaction site [nucleotide binding]; other site 391735003762 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 391735003763 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 391735003764 elongation factor G; Reviewed; Region: PRK00007 391735003765 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 391735003766 G1 box; other site 391735003767 putative GEF interaction site [polypeptide binding]; other site 391735003768 GTP/Mg2+ binding site [chemical binding]; other site 391735003769 Switch I region; other site 391735003770 G2 box; other site 391735003771 G3 box; other site 391735003772 Switch II region; other site 391735003773 G4 box; other site 391735003774 G5 box; other site 391735003775 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 391735003776 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 391735003777 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 391735003778 elongation factor Tu; Reviewed; Region: PRK00049 391735003779 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 391735003780 G1 box; other site 391735003781 GEF interaction site [polypeptide binding]; other site 391735003782 GTP/Mg2+ binding site [chemical binding]; other site 391735003783 Switch I region; other site 391735003784 G2 box; other site 391735003785 G3 box; other site 391735003786 Switch II region; other site 391735003787 G4 box; other site 391735003788 G5 box; other site 391735003789 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 391735003790 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 391735003791 Antibiotic Binding Site [chemical binding]; other site 391735003792 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 391735003793 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 391735003794 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 391735003795 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 391735003796 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 391735003797 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 391735003798 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 391735003799 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 391735003800 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 391735003801 protein-rRNA interface [nucleotide binding]; other site 391735003802 putative translocon binding site; other site 391735003803 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 391735003804 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 391735003805 G-X-X-G motif; other site 391735003806 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 391735003807 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 391735003808 23S rRNA interface [nucleotide binding]; other site 391735003809 5S rRNA interface [nucleotide binding]; other site 391735003810 putative antibiotic binding site [chemical binding]; other site 391735003811 L25 interface [polypeptide binding]; other site 391735003812 L27 interface [polypeptide binding]; other site 391735003813 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cl09943 391735003814 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 391735003815 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 391735003816 catalytic triad [active] 391735003817 dimer interface [polypeptide binding]; other site 391735003818 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 391735003819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391735003820 Coenzyme A binding pocket [chemical binding]; other site 391735003821 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 391735003822 Cytochrome C'; Region: Cytochrom_C_2; cl01610 391735003823 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 391735003824 catalytic residues [active] 391735003825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735003826 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 391735003827 active pocket/dimerization site; other site 391735003828 active site 391735003829 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 391735003830 dimerization domain swap beta strand [polypeptide binding]; other site 391735003831 regulatory protein interface [polypeptide binding]; other site 391735003832 active site 391735003833 regulatory phosphorylation site [posttranslational modification]; other site 391735003834 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 391735003835 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 391735003836 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 391735003837 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 391735003838 Transposase domain (DUF772); Region: DUF772; cl12084 391735003839 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391735003840 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 391735003841 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391735003842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391735003843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735003844 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 391735003845 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391735003846 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 391735003847 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 391735003848 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735003849 catalytic residue [active] 391735003850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 391735003851 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 391735003852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 391735003853 dimer interface [polypeptide binding]; other site 391735003854 phosphorylation site [posttranslational modification] 391735003855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735003856 ATP binding site [chemical binding]; other site 391735003857 Mg2+ binding site [ion binding]; other site 391735003858 G-X-G motif; other site 391735003859 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 391735003860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735003861 active site 391735003862 phosphorylation site [posttranslational modification] 391735003863 intermolecular recognition site; other site 391735003864 dimerization interface [polypeptide binding]; other site 391735003865 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 391735003866 DNA binding site [nucleotide binding] 391735003867 transcriptional regulator PhoU; Provisional; Region: PRK11115 391735003868 PhoU domain; Region: PhoU; pfam01895 391735003869 PhoU domain; Region: PhoU; pfam01895 391735003870 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 391735003871 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 391735003872 Walker A/P-loop; other site 391735003873 ATP binding site [chemical binding]; other site 391735003874 Q-loop/lid; other site 391735003875 ABC transporter signature motif; other site 391735003876 Walker B; other site 391735003877 D-loop; other site 391735003878 H-loop/switch region; other site 391735003879 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 391735003880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735003881 dimer interface [polypeptide binding]; other site 391735003882 conserved gate region; other site 391735003883 putative PBP binding loops; other site 391735003884 ABC-ATPase subunit interface; other site 391735003885 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 391735003886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735003887 dimer interface [polypeptide binding]; other site 391735003888 conserved gate region; other site 391735003889 putative PBP binding loops; other site 391735003890 ABC-ATPase subunit interface; other site 391735003891 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735003892 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 391735003893 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 391735003894 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391735003895 catalytic core [active] 391735003896 polyphosphate kinase; Provisional; Region: PRK05443 391735003897 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 391735003898 putative active site [active] 391735003899 catalytic site [active] 391735003900 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 391735003901 putative domain interface [polypeptide binding]; other site 391735003902 putative active site [active] 391735003903 catalytic site [active] 391735003904 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391735003905 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735003906 Walker A/P-loop; other site 391735003907 ATP binding site [chemical binding]; other site 391735003908 Q-loop/lid; other site 391735003909 ABC transporter signature motif; other site 391735003910 Walker B; other site 391735003911 D-loop; other site 391735003912 H-loop/switch region; other site 391735003913 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735003914 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735003915 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735003916 Walker A/P-loop; other site 391735003917 ATP binding site [chemical binding]; other site 391735003918 Q-loop/lid; other site 391735003919 ABC transporter signature motif; other site 391735003920 Walker B; other site 391735003921 D-loop; other site 391735003922 H-loop/switch region; other site 391735003923 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735003924 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391735003925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735003926 dimer interface [polypeptide binding]; other site 391735003927 conserved gate region; other site 391735003928 putative PBP binding loops; other site 391735003929 ABC-ATPase subunit interface; other site 391735003930 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391735003931 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 391735003932 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391735003933 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 391735003934 metal binding site [ion binding]; metal-binding site 391735003935 putative dimer interface [polypeptide binding]; other site 391735003936 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735003937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735003938 dimer interface [polypeptide binding]; other site 391735003939 conserved gate region; other site 391735003940 putative PBP binding loops; other site 391735003941 ABC-ATPase subunit interface; other site 391735003942 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 391735003943 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735003944 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 391735003945 eyelet of channel; other site 391735003946 trimer interface [polypeptide binding]; other site 391735003947 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 391735003948 dinuclear metal binding motif [ion binding]; other site 391735003949 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 391735003950 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 391735003951 putative active site [active] 391735003952 catalytic site [active] 391735003953 putative metal binding site [ion binding]; other site 391735003954 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 391735003955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735003956 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 391735003957 L-serine binding site [chemical binding]; other site 391735003958 ACT domain interface; other site 391735003959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735003960 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 391735003961 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391735003962 FAD binding domain; Region: FAD_binding_4; pfam01565 391735003963 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 391735003964 Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150 391735003965 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 391735003966 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 391735003967 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391735003968 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735003969 substrate binding pocket [chemical binding]; other site 391735003970 membrane-bound complex binding site; other site 391735003971 hinge residues; other site 391735003972 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391735003973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735003974 dimer interface [polypeptide binding]; other site 391735003975 conserved gate region; other site 391735003976 putative PBP binding loops; other site 391735003977 ABC-ATPase subunit interface; other site 391735003978 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391735003979 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 391735003980 Walker A/P-loop; other site 391735003981 ATP binding site [chemical binding]; other site 391735003982 Q-loop/lid; other site 391735003983 ABC transporter signature motif; other site 391735003984 Walker B; other site 391735003985 D-loop; other site 391735003986 H-loop/switch region; other site 391735003987 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391735003988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735003989 DNA-binding site [nucleotide binding]; DNA binding site 391735003990 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 391735003991 Protein of unknown function (DUF971); Region: DUF971; cl01414 391735003992 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 391735003993 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 391735003994 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 391735003995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 391735003996 S-adenosylmethionine binding site [chemical binding]; other site 391735003997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735003998 Tim44-like domain; Region: Tim44; cl09208 391735003999 SCP-2 sterol transfer family; Region: SCP2; cl01225 391735004000 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 391735004001 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 391735004002 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 391735004003 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 391735004004 Protein of unknown function (DUF502); Region: DUF502; cl01107 391735004005 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 391735004006 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 391735004007 dimer interface [polypeptide binding]; other site 391735004008 anticodon binding site; other site 391735004009 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 391735004010 homodimer interface [polypeptide binding]; other site 391735004011 motif 1; other site 391735004012 active site 391735004013 motif 2; other site 391735004014 GAD domain; Region: GAD; pfam02938 391735004015 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 391735004016 motif 3; other site 391735004017 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391735004018 putative catalytic site [active] 391735004019 putative metal binding site [ion binding]; other site 391735004020 putative phosphate binding site [ion binding]; other site 391735004021 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 391735004022 putative active site [active] 391735004023 catalytic site [active] 391735004024 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 391735004025 putative active site [active] 391735004026 catalytic site [active] 391735004027 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 391735004028 active site 391735004029 Sensors of blue-light using FAD; Region: BLUF; pfam04940 391735004030 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 391735004031 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391735004032 dimer interface [polypeptide binding]; other site 391735004033 active site 391735004034 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 391735004035 active site clefts [active] 391735004036 zinc binding site [ion binding]; other site 391735004037 dimer interface [polypeptide binding]; other site 391735004038 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 391735004039 isovaleryl-CoA dehydrogenase; Region: PLN02519 391735004040 substrate binding site [chemical binding]; other site 391735004041 FAD binding site [chemical binding]; other site 391735004042 catalytic base [active] 391735004043 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 391735004044 Cation efflux family; Region: Cation_efflux; cl00316 391735004045 UGMP family protein; Validated; Region: PRK09604 391735004046 guanine deaminase; Provisional; Region: PRK09228 391735004047 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735004048 active site 391735004049 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 391735004050 trimer interface [polypeptide binding]; other site 391735004051 active site 391735004052 ornithine cyclodeaminase; Validated; Region: PRK07340 391735004053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735004054 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 391735004055 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 391735004056 ATP binding site [chemical binding]; other site 391735004057 Mg++ binding site [ion binding]; other site 391735004058 motif III; other site 391735004059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391735004060 nucleotide binding region [chemical binding]; other site 391735004061 ATP-binding site [chemical binding]; other site 391735004062 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 391735004063 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 391735004064 active site 391735004065 metal binding site [ion binding]; metal-binding site 391735004066 H-NS histone family; Region: Histone_HNS; pfam00816 391735004067 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 391735004068 aconitate hydratase; Validated; Region: PRK09277 391735004069 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 391735004070 substrate binding site [chemical binding]; other site 391735004071 ligand binding site [chemical binding]; other site 391735004072 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 391735004073 substrate binding site [chemical binding]; other site 391735004074 PAS fold; Region: PAS_4; pfam08448 391735004075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391735004076 putative active site [active] 391735004077 heme pocket [chemical binding]; other site 391735004078 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391735004079 metal binding site [ion binding]; metal-binding site 391735004080 active site 391735004081 I-site; other site 391735004082 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391735004083 PAS fold; Region: PAS_7; pfam12860 391735004084 PAS domain S-box; Region: sensory_box; TIGR00229 391735004085 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 391735004086 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391735004087 metal binding site [ion binding]; metal-binding site 391735004088 active site 391735004089 I-site; other site 391735004090 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391735004091 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735004092 enoyl-CoA hydratase; Provisional; Region: PRK05995 391735004093 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735004094 substrate binding site [chemical binding]; other site 391735004095 oxyanion hole (OAH) forming residues; other site 391735004096 trimer interface [polypeptide binding]; other site 391735004097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735004098 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735004099 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 391735004100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735004101 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735004102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735004103 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735004104 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 391735004105 putative dimerization interface [polypeptide binding]; other site 391735004106 Histidine kinase; Region: His_kinase; pfam06580 391735004107 argininosuccinate lyase; Provisional; Region: PRK00855 391735004108 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 391735004109 active sites [active] 391735004110 tetramer interface [polypeptide binding]; other site 391735004111 NIMA-related protein kinase; Provisional; Region: PTZ00266 391735004112 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735004113 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 391735004114 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391735004115 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735004116 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735004117 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735004118 Walker A/P-loop; other site 391735004119 ATP binding site [chemical binding]; other site 391735004120 Q-loop/lid; other site 391735004121 ABC transporter signature motif; other site 391735004122 Walker B; other site 391735004123 D-loop; other site 391735004124 H-loop/switch region; other site 391735004125 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735004126 TM-ABC transporter signature motif; other site 391735004127 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735004128 TM-ABC transporter signature motif; other site 391735004129 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735004130 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391735004131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735004132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735004133 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 391735004134 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735004135 dimerization interface [polypeptide binding]; other site 391735004136 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391735004137 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 391735004138 FMN-binding pocket [chemical binding]; other site 391735004139 flavin binding motif; other site 391735004140 phosphate binding motif [ion binding]; other site 391735004141 beta-alpha-beta structure motif; other site 391735004142 NAD binding pocket [chemical binding]; other site 391735004143 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735004144 catalytic loop [active] 391735004145 iron binding site [ion binding]; other site 391735004146 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391735004147 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 391735004148 iron-sulfur cluster [ion binding]; other site 391735004149 [2Fe-2S] cluster binding site [ion binding]; other site 391735004150 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 391735004151 alpha subunit interface [polypeptide binding]; other site 391735004152 active site 391735004153 substrate binding site [chemical binding]; other site 391735004154 Fe binding site [ion binding]; other site 391735004155 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 391735004156 putative dimer interface [polypeptide binding]; other site 391735004157 putative N- and C-terminal domain interface [polypeptide binding]; other site 391735004158 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391735004159 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 391735004160 iron-sulfur cluster [ion binding]; other site 391735004161 [2Fe-2S] cluster binding site [ion binding]; other site 391735004162 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391735004163 hydrophobic ligand binding site; other site 391735004164 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391735004165 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 391735004166 FMN-binding pocket [chemical binding]; other site 391735004167 flavin binding motif; other site 391735004168 phosphate binding motif [ion binding]; other site 391735004169 beta-alpha-beta structure motif; other site 391735004170 NAD binding pocket [chemical binding]; other site 391735004171 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735004172 catalytic loop [active] 391735004173 iron binding site [ion binding]; other site 391735004174 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 391735004175 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735004176 DNA-binding site [nucleotide binding]; DNA binding site 391735004177 FCD domain; Region: FCD; cl11656 391735004178 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 391735004179 trimer interface [polypeptide binding]; other site 391735004180 eyelet of channel; other site 391735004181 Transposase domain (DUF772); Region: DUF772; cl12084 391735004182 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 391735004183 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 391735004184 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 391735004185 Cytochrome c; Region: Cytochrom_C; cl11414 391735004186 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 391735004187 Subunit I/III interface [polypeptide binding]; other site 391735004188 D-pathway; other site 391735004189 Subunit I/VIIc interface [polypeptide binding]; other site 391735004190 Subunit I/IV interface [polypeptide binding]; other site 391735004191 Subunit I/II interface [polypeptide binding]; other site 391735004192 Low-spin heme (heme a) binding site [chemical binding]; other site 391735004193 Subunit I/VIIa interface [polypeptide binding]; other site 391735004194 Subunit I/VIa interface [polypeptide binding]; other site 391735004195 Dimer interface; other site 391735004196 Putative water exit pathway; other site 391735004197 Binuclear center (heme a3/CuB) [ion binding]; other site 391735004198 K-pathway; other site 391735004199 Subunit I/Vb interface [polypeptide binding]; other site 391735004200 Putative proton exit pathway; other site 391735004201 Subunit I/VIb interface; other site 391735004202 Subunit I/VIc interface [polypeptide binding]; other site 391735004203 Electron transfer pathway; other site 391735004204 Subunit I/VIIIb interface [polypeptide binding]; other site 391735004205 Subunit I/VIIb interface [polypeptide binding]; other site 391735004206 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 391735004207 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 391735004208 Subunit III/VIIa interface [polypeptide binding]; other site 391735004209 Phospholipid binding site [chemical binding]; other site 391735004210 Subunit I/III interface [polypeptide binding]; other site 391735004211 Subunit III/VIb interface [polypeptide binding]; other site 391735004212 Subunit III/VIa interface; other site 391735004213 Subunit III/Vb interface [polypeptide binding]; other site 391735004214 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 391735004215 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 391735004216 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 391735004217 UbiA prenyltransferase family; Region: UbiA; cl00337 391735004218 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 391735004219 Cu(I) binding site [ion binding]; other site 391735004220 UreD urease accessory protein; Region: UreD; cl00530 391735004221 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391735004222 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391735004223 DNA binding site [nucleotide binding] 391735004224 domain linker motif; other site 391735004225 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 391735004226 dimerization interface [polypeptide binding]; other site 391735004227 ligand binding site [chemical binding]; other site 391735004228 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391735004229 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735004230 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 391735004231 active site 391735004232 trimer interface [polypeptide binding]; other site 391735004233 allosteric site; other site 391735004234 active site lid [active] 391735004235 hexamer (dimer of trimers) interface [polypeptide binding]; other site 391735004236 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735004237 active site 391735004238 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391735004239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735004240 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 391735004241 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 391735004242 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 391735004243 active site 391735004244 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 391735004245 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 391735004246 dimer interface [polypeptide binding]; other site 391735004247 Citrate synthase; Region: Citrate_synt; pfam00285 391735004248 active site 391735004249 citrylCoA binding site [chemical binding]; other site 391735004250 NADH binding [chemical binding]; other site 391735004251 cationic pore residues; other site 391735004252 oxalacetate/citrate binding site [chemical binding]; other site 391735004253 coenzyme A binding site [chemical binding]; other site 391735004254 catalytic triad [active] 391735004255 Integrase core domain; Region: rve; cl01316 391735004256 putative transposase OrfB; Reviewed; Region: PHA02517 391735004257 Integrase core domain; Region: rve; cl01316 391735004258 multiple promoter invertase; Provisional; Region: mpi; PRK13413 391735004259 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391735004260 catalytic residues [active] 391735004261 catalytic nucleophile [active] 391735004262 Presynaptic Site I dimer interface [polypeptide binding]; other site 391735004263 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391735004264 Synaptic Flat tetramer interface [polypeptide binding]; other site 391735004265 Synaptic Site I dimer interface [polypeptide binding]; other site 391735004266 DNA binding site [nucleotide binding] 391735004267 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391735004268 DNA-binding interface [nucleotide binding]; DNA binding site 391735004269 Protein of unknown function DUF86; Region: DUF86; cl01031 391735004270 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 391735004271 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723 391735004272 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 391735004273 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 391735004274 Integrase core domain; Region: rve; cl01316 391735004275 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 391735004276 Integrase core domain; Region: rve; cl01316 391735004277 putative transposase OrfB; Reviewed; Region: PHA02517 391735004278 ribonuclease R; Region: RNase_R; TIGR02063 391735004279 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 391735004280 RNB domain; Region: RNB; pfam00773 391735004281 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 391735004282 RNA binding site [nucleotide binding]; other site 391735004283 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 391735004284 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 391735004285 putative ATP binding site [chemical binding]; other site 391735004286 putative substrate binding site [chemical binding]; other site 391735004287 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391735004288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735004289 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 391735004290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735004291 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735004292 Protein of unknown function (DUF1185); Region: DUF1185; pfam06684 391735004293 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391735004294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735004295 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 391735004296 Integrase core domain; Region: rve; cl01316 391735004297 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 391735004298 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 391735004299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735004300 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 391735004301 putative dimerization interface [polypeptide binding]; other site 391735004302 amidase; Provisional; Region: PRK07056 391735004303 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 391735004304 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 391735004305 rRNA interaction site [nucleotide binding]; other site 391735004306 S8 interaction site; other site 391735004307 putative laminin-1 binding site; other site 391735004308 elongation factor Ts; Provisional; Region: tsf; PRK09377 391735004309 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 391735004310 Elongation factor TS; Region: EF_TS; pfam00889 391735004311 Elongation factor TS; Region: EF_TS; pfam00889 391735004312 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 391735004313 putative nucleotide binding site [chemical binding]; other site 391735004314 uridine monophosphate binding site [chemical binding]; other site 391735004315 homohexameric interface [polypeptide binding]; other site 391735004316 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 391735004317 hinge region; other site 391735004318 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 391735004319 catalytic residue [active] 391735004320 putative FPP diphosphate binding site; other site 391735004321 putative FPP binding hydrophobic cleft; other site 391735004322 dimer interface [polypeptide binding]; other site 391735004323 putative IPP diphosphate binding site; other site 391735004324 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 391735004325 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 391735004326 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 391735004327 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 391735004328 zinc metallopeptidase RseP; Provisional; Region: PRK10779 391735004329 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 391735004330 active site 391735004331 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 391735004332 protein binding site [polypeptide binding]; other site 391735004333 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 391735004334 putative substrate binding region [chemical binding]; other site 391735004335 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 391735004336 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 391735004337 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 391735004338 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 391735004339 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 391735004340 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 391735004341 Surface antigen; Region: Bac_surface_Ag; cl03097 391735004342 Outer membrane protein (OmpH-like); Region: OmpH; cl08146 391735004343 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 391735004344 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 391735004345 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 391735004346 trimer interface [polypeptide binding]; other site 391735004347 active site 391735004348 UDP-GlcNAc binding site [chemical binding]; other site 391735004349 lipid binding site [chemical binding]; lipid-binding site 391735004350 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 391735004351 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 391735004352 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 391735004353 active site 391735004354 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 391735004355 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 391735004356 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 391735004357 RNA/DNA hybrid binding site [nucleotide binding]; other site 391735004358 active site 391735004359 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 391735004360 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 391735004361 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 391735004362 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 391735004363 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 391735004364 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 391735004365 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 391735004366 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 391735004367 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 391735004368 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391735004369 catalytic core [active] 391735004370 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 391735004371 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 391735004372 Ligand Binding Site [chemical binding]; other site 391735004373 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 391735004374 active site 391735004375 short chain dehydrogenase; Provisional; Region: PRK12939 391735004376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735004377 NAD(P) binding site [chemical binding]; other site 391735004378 active site 391735004379 Uncharacterized conserved protein [Function unknown]; Region: COG1565 391735004380 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 391735004381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 391735004382 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 391735004383 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 391735004384 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 391735004385 active site 391735004386 NTP binding site [chemical binding]; other site 391735004387 metal binding triad [ion binding]; metal-binding site 391735004388 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 391735004389 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 391735004390 glutathione S-transferase; Provisional; Region: PRK15113 391735004391 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH)...; Region: GST_N_1; cd03043 391735004392 putative C-terminal domain interface [polypeptide binding]; other site 391735004393 putative GSH binding site (G-site) [chemical binding]; other site 391735004394 putative dimer interface [polypeptide binding]; other site 391735004395 GST_C family, unknown subfamily 3; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous...; Region: GST_C_3; cd03194 391735004396 putative N-terminal domain interface [polypeptide binding]; other site 391735004397 putative dimer interface [polypeptide binding]; other site 391735004398 putative substrate binding pocket (H-site) [chemical binding]; other site 391735004399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735004400 putative substrate translocation pore; other site 391735004401 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 391735004402 lytic murein transglycosylase; Provisional; Region: PRK11619 391735004403 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 391735004404 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391735004405 catalytic residue [active] 391735004406 BtpA family; Region: BtpA; cl00440 391735004407 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 391735004408 substrate binding site [chemical binding]; other site 391735004409 dimer interface [polypeptide binding]; other site 391735004410 ATP binding site [chemical binding]; other site 391735004411 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 391735004412 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 391735004413 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active...; Region: PTE; cd00530 391735004414 active site 391735004415 substrate binding pocket [chemical binding]; other site 391735004416 homodimer interaction site [polypeptide binding]; other site 391735004417 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735004418 TM-ABC transporter signature motif; other site 391735004419 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735004420 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391735004421 Walker A/P-loop; other site 391735004422 ATP binding site [chemical binding]; other site 391735004423 Q-loop/lid; other site 391735004424 ABC transporter signature motif; other site 391735004425 Walker B; other site 391735004426 D-loop; other site 391735004427 H-loop/switch region; other site 391735004428 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391735004429 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391735004430 ligand binding site [chemical binding]; other site 391735004431 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391735004432 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391735004433 DNA binding site [nucleotide binding] 391735004434 domain linker motif; other site 391735004435 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 391735004436 putative dimerization interface [polypeptide binding]; other site 391735004437 putative ligand binding site [chemical binding]; other site 391735004438 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391735004439 catalytic core [active] 391735004440 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391735004441 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 391735004442 iron-sulfur cluster [ion binding]; other site 391735004443 [2Fe-2S] cluster binding site [ion binding]; other site 391735004444 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 391735004445 alpha subunit interface [polypeptide binding]; other site 391735004446 active site 391735004447 substrate binding site [chemical binding]; other site 391735004448 Fe binding site [ion binding]; other site 391735004449 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 391735004450 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391735004451 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391735004452 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 391735004453 catalytic residues [active] 391735004454 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 391735004455 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 391735004456 carboxyltransferase (CT) interaction site; other site 391735004457 biotinylation site [posttranslational modification]; other site 391735004458 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 391735004459 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391735004460 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735004461 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 391735004462 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 391735004463 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 391735004464 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 391735004465 substrate binding site [chemical binding]; other site 391735004466 ATP binding site [chemical binding]; other site 391735004467 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 391735004468 dimer interface [polypeptide binding]; other site 391735004469 putative radical transfer pathway; other site 391735004470 diiron center [ion binding]; other site 391735004471 tyrosyl radical; other site 391735004472 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 391735004473 ATP cone domain; Region: ATP-cone; pfam03477 391735004474 Class I ribonucleotide reductase; Region: RNR_I; cd01679 391735004475 active site 391735004476 dimer interface [polypeptide binding]; other site 391735004477 catalytic residues [active] 391735004478 effector binding site; other site 391735004479 R2 peptide binding site; other site 391735004480 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 391735004481 amidase catalytic site [active] 391735004482 Zn binding residues [ion binding]; other site 391735004483 substrate binding site [chemical binding]; other site 391735004484 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391735004485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735004486 active site 391735004487 phosphorylation site [posttranslational modification] 391735004488 intermolecular recognition site; other site 391735004489 dimerization interface [polypeptide binding]; other site 391735004490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735004491 Walker A motif; other site 391735004492 ATP binding site [chemical binding]; other site 391735004493 Walker B motif; other site 391735004494 arginine finger; other site 391735004495 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 391735004496 sensory histidine kinase AtoS; Provisional; Region: PRK11360 391735004497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 391735004498 dimer interface [polypeptide binding]; other site 391735004499 phosphorylation site [posttranslational modification] 391735004500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735004501 ATP binding site [chemical binding]; other site 391735004502 Mg2+ binding site [ion binding]; other site 391735004503 G-X-G motif; other site 391735004504 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 391735004505 signal recognition particle protein; Provisional; Region: PRK10867 391735004506 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 391735004507 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 391735004508 GTP binding site [chemical binding]; other site 391735004509 Signal peptide binding domain; Region: SRP_SPB; pfam02978 391735004510 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 391735004511 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 391735004512 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 391735004513 Substrate binding site [chemical binding]; other site 391735004514 Mg++ binding site [ion binding]; other site 391735004515 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 391735004516 active site 391735004517 substrate binding site [chemical binding]; other site 391735004518 CoA binding site [chemical binding]; other site 391735004519 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 391735004520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735004521 ATP binding site [chemical binding]; other site 391735004522 Mg2+ binding site [ion binding]; other site 391735004523 G-X-G motif; other site 391735004524 Integral membrane protein TerC family; Region: TerC; cl10468 391735004525 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 391735004526 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391735004527 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735004528 Walker A/P-loop; other site 391735004529 ATP binding site [chemical binding]; other site 391735004530 Q-loop/lid; other site 391735004531 ABC transporter signature motif; other site 391735004532 Walker B; other site 391735004533 D-loop; other site 391735004534 H-loop/switch region; other site 391735004535 TOBE domain; Region: TOBE_2; cl01440 391735004536 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 391735004537 oligomeric interface; other site 391735004538 putative active site [active] 391735004539 homodimer interface [polypeptide binding]; other site 391735004540 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 391735004541 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 391735004542 putative active site [active] 391735004543 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391735004544 putative acyl-acceptor binding pocket; other site 391735004545 dihydroorotase; Provisional; Region: PRK07627 391735004546 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735004547 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 391735004548 active site 391735004549 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 391735004550 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 391735004551 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 391735004552 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 391735004553 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 391735004554 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 391735004555 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 391735004556 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 391735004557 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391735004558 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 391735004559 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 391735004560 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 391735004561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735004562 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735004563 ThiC family; Region: ThiC; cl08031 391735004564 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735004565 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 391735004566 homotrimer interaction site [polypeptide binding]; other site 391735004567 putative active site [active] 391735004568 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 391735004569 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 391735004570 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 391735004571 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 391735004572 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 391735004573 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735004574 TM-ABC transporter signature motif; other site 391735004575 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735004576 TM-ABC transporter signature motif; other site 391735004577 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735004578 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735004579 Walker A/P-loop; other site 391735004580 ATP binding site [chemical binding]; other site 391735004581 Q-loop/lid; other site 391735004582 ABC transporter signature motif; other site 391735004583 Walker B; other site 391735004584 D-loop; other site 391735004585 H-loop/switch region; other site 391735004586 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735004587 Q-loop/lid; other site 391735004588 ABC transporter signature motif; other site 391735004589 Walker B; other site 391735004590 D-loop; other site 391735004591 H-loop/switch region; other site 391735004592 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391735004593 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 391735004594 putative ligand binding site [chemical binding]; other site 391735004595 galactarate dehydratase; Region: galactar-dH20; TIGR03248 391735004596 SAF domain; Region: SAF; cl00555 391735004597 SAF domain; Region: SAF; cl00555 391735004598 DctM-like transporters; Region: DctM; pfam06808 391735004599 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 391735004600 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391735004601 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 391735004602 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 391735004603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735004604 DNA-binding site [nucleotide binding]; DNA binding site 391735004605 FCD domain; Region: FCD; cl11656 391735004606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735004607 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735004608 NAD(P) binding site [chemical binding]; other site 391735004609 active site 391735004610 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 391735004611 SUA5 domain; Region: SUA5; pfam03481 391735004612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735004613 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 391735004614 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735004615 AIR carboxylase; Region: AIRC; cl00310 391735004616 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 391735004617 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 391735004618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 391735004619 META domain; Region: META; cl01245 391735004620 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 391735004621 ATP binding site [chemical binding]; other site 391735004622 active site 391735004623 substrate binding site [chemical binding]; other site 391735004624 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 391735004625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735004626 putative substrate translocation pore; other site 391735004627 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391735004628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735004629 NAD(P) binding site [chemical binding]; other site 391735004630 active site 391735004631 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 391735004632 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 391735004633 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 391735004634 tRNA; other site 391735004635 putative tRNA binding site [nucleotide binding]; other site 391735004636 putative NADP binding site [chemical binding]; other site 391735004637 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 391735004638 peptide chain release factor 1; Validated; Region: prfA; PRK00591 391735004639 RF-1 domain; Region: RF-1; cl02875 391735004640 RF-1 domain; Region: RF-1; cl02875 391735004641 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 391735004642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735004643 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 391735004644 putative GSH binding site [chemical binding]; other site 391735004645 catalytic residues [active] 391735004646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735004647 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 391735004648 Walker A motif; other site 391735004649 ATP binding site [chemical binding]; other site 391735004650 Walker B motif; other site 391735004651 arginine finger; other site 391735004652 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 391735004653 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 391735004654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735004655 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735004656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735004657 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 391735004658 HsdM N-terminal domain; Region: HsdM_N; pfam12161 391735004659 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 391735004660 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 391735004661 Virulence protein [General function prediction only]; Region: COG3943 391735004662 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 391735004663 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 391735004664 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735004665 ATP binding site [chemical binding]; other site 391735004666 putative Mg++ binding site [ion binding]; other site 391735004667 Protein of unknown function DUF45; Region: DUF45; cl00636 391735004668 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391735004669 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391735004670 ferrochelatase; Reviewed; Region: hemH; PRK00035 391735004671 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 391735004672 C-terminal domain interface [polypeptide binding]; other site 391735004673 active site 391735004674 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 391735004675 active site 391735004676 N-terminal domain interface [polypeptide binding]; other site 391735004677 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 391735004678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 391735004679 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 391735004680 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 391735004681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735004682 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735004683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735004684 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735004685 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 391735004686 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735004687 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 391735004688 putative active site [active] 391735004689 putative catalytic site [active] 391735004690 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735004691 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735004692 active site 391735004693 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 391735004694 putative active site [active] 391735004695 putative catalytic site [active] 391735004696 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 391735004697 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391735004698 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735004699 DNA-binding site [nucleotide binding]; DNA binding site 391735004700 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391735004701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735004702 homodimer interface [polypeptide binding]; other site 391735004703 catalytic residue [active] 391735004704 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 391735004705 homotrimer interaction site [polypeptide binding]; other site 391735004706 putative active site [active] 391735004707 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 391735004708 active site 391735004709 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 391735004710 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 391735004711 glutamine binding [chemical binding]; other site 391735004712 catalytic triad [active] 391735004713 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 391735004714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735004715 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391735004716 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391735004717 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735004718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735004719 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 391735004720 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391735004721 sulfite oxidase; Provisional; Region: PLN00177 391735004722 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 391735004723 Moco binding site; other site 391735004724 metal coordination site [ion binding]; other site 391735004725 dimerization interface [polypeptide binding]; other site 391735004726 Cytochrome c; Region: Cytochrom_C; cl11414 391735004727 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 391735004728 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735004729 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391735004730 substrate binding pocket [chemical binding]; other site 391735004731 membrane-bound complex binding site; other site 391735004732 hinge residues; other site 391735004733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735004734 dimer interface [polypeptide binding]; other site 391735004735 conserved gate region; other site 391735004736 putative PBP binding loops; other site 391735004737 ABC-ATPase subunit interface; other site 391735004738 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391735004739 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 391735004740 Walker A/P-loop; other site 391735004741 ATP binding site [chemical binding]; other site 391735004742 Q-loop/lid; other site 391735004743 ABC transporter signature motif; other site 391735004744 Walker B; other site 391735004745 D-loop; other site 391735004746 H-loop/switch region; other site 391735004747 EamA-like transporter family; Region: EamA; cl01037 391735004748 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 391735004749 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 391735004750 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 391735004751 rod shape-determining protein MreD; Region: MreD; cl01087 391735004752 rod shape-determining protein MreC; Provisional; Region: PRK13922 391735004753 rod shape-determining protein MreC; Region: MreC; pfam04085 391735004754 rod shape-determining protein MreB; Provisional; Region: PRK13927 391735004755 Cell division protein FtsA; Region: FtsA; cl11496 391735004756 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 391735004757 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391735004758 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 391735004759 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 391735004760 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 391735004761 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 391735004762 GatB domain; Region: GatB_Yqey; cl11497 391735004763 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 391735004764 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 391735004765 putative active site [active] 391735004766 putative DNA binding site [nucleotide binding]; other site 391735004767 putative phosphate binding site [ion binding]; other site 391735004768 putative catalytic site [active] 391735004769 metal binding site A [ion binding]; metal-binding site 391735004770 putative AP binding site [nucleotide binding]; other site 391735004771 putative metal binding site B [ion binding]; other site 391735004772 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 391735004773 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 391735004774 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735004775 Walker A motif; other site 391735004776 ATP binding site [chemical binding]; other site 391735004777 Walker B motif; other site 391735004778 selenophosphate synthetase; Provisional; Region: PRK00943 391735004779 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 391735004780 dimerization interface [polypeptide binding]; other site 391735004781 putative ATP binding site [chemical binding]; other site 391735004782 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 391735004783 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391735004784 active site residue [active] 391735004785 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 391735004786 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 391735004787 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 391735004788 active site 391735004789 HIGH motif; other site 391735004790 dimer interface [polypeptide binding]; other site 391735004791 KMSKS motif; other site 391735004792 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 391735004793 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 391735004794 active site 391735004795 putative substrate binding region [chemical binding]; other site 391735004796 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 391735004797 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 391735004798 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 391735004799 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391735004800 Ligand Binding Site [chemical binding]; other site 391735004801 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051 391735004802 Ca2+ binding site [ion binding]; other site 391735004803 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 391735004804 general secretion pathway protein F; Region: GspF; TIGR02120 391735004805 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 391735004806 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 391735004807 septum site-determining protein MinC; Region: minC; TIGR01222 391735004808 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 391735004809 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 391735004810 cell division inhibitor MinD; Provisional; Region: PRK10818 391735004811 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 391735004812 Switch I; other site 391735004813 Switch II; other site 391735004814 Septum formation topological specificity factor MinE; Region: MinE; cl00538 391735004815 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 391735004816 active site 391735004817 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 391735004818 active site 1 [active] 391735004819 dimer interface [polypeptide binding]; other site 391735004820 hexamer interface [polypeptide binding]; other site 391735004821 active site 2 [active] 391735004822 LysE type translocator; Region: LysE; cl00565 391735004823 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 391735004824 Outer membrane efflux protein; Region: OEP; pfam02321 391735004825 Outer membrane efflux protein; Region: OEP; pfam02321 391735004826 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 391735004827 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 391735004828 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 391735004829 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 391735004830 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 391735004831 Walker A/P-loop; other site 391735004832 ATP binding site [chemical binding]; other site 391735004833 Q-loop/lid; other site 391735004834 ABC transporter signature motif; other site 391735004835 Walker B; other site 391735004836 D-loop; other site 391735004837 H-loop/switch region; other site 391735004838 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 391735004839 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 391735004840 Walker A/P-loop; other site 391735004841 ATP binding site [chemical binding]; other site 391735004842 Q-loop/lid; other site 391735004843 ABC transporter signature motif; other site 391735004844 Walker B; other site 391735004845 D-loop; other site 391735004846 H-loop/switch region; other site 391735004847 malic enzyme; Reviewed; Region: PRK12862 391735004848 Malic enzyme, N-terminal domain; Region: malic; pfam00390 391735004849 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 391735004850 putative NAD(P) binding site [chemical binding]; other site 391735004851 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 391735004852 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 391735004853 active site 391735004854 DNA polymerase IV; Validated; Region: PRK02406 391735004855 DNA binding site [nucleotide binding] 391735004856 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 391735004857 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 391735004858 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 391735004859 catalytic triad [active] 391735004860 conserved cis-peptide bond; other site 391735004861 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 391735004862 LytB protein; Region: LYTB; cl00507 391735004863 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 391735004864 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 391735004865 hypothetical protein; Reviewed; Region: PRK00024 391735004866 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 391735004867 MPN+ (JAMM) motif; other site 391735004868 Zinc-binding site [ion binding]; other site 391735004869 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 391735004870 putative di-iron ligands [ion binding]; other site 391735004871 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 391735004872 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa...; Region: ACD_sHsps_p23-like; cd00298 391735004873 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 391735004874 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391735004875 putative acyl-acceptor binding pocket; other site 391735004876 enoyl-CoA hydratase; Provisional; Region: PRK06143 391735004877 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735004878 substrate binding site [chemical binding]; other site 391735004879 oxyanion hole (OAH) forming residues; other site 391735004880 trimer interface [polypeptide binding]; other site 391735004881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735004882 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391735004883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735004884 putative substrate translocation pore; other site 391735004885 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 391735004886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735004887 ATP binding site [chemical binding]; other site 391735004888 Mg2+ binding site [ion binding]; other site 391735004889 G-X-G motif; other site 391735004890 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 391735004891 anchoring element; other site 391735004892 dimer interface [polypeptide binding]; other site 391735004893 ATP binding site [chemical binding]; other site 391735004894 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 391735004895 active site 391735004896 metal binding site [ion binding]; metal-binding site 391735004897 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 391735004898 Cation efflux family; Region: Cation_efflux; cl00316 391735004899 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 391735004900 Protein of unknown function, DUF; Region: DUF411; cl01142 391735004901 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-; Region: nylC_like; cd02252 391735004902 putative active site pocket [active] 391735004903 cleavage site 391735004904 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 391735004905 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 391735004906 motif 1; other site 391735004907 active site 391735004908 motif 2; other site 391735004909 motif 3; other site 391735004910 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 391735004911 DHHA1 domain; Region: DHHA1; pfam02272 391735004912 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391735004913 metal binding site [ion binding]; metal-binding site 391735004914 active site 391735004915 I-site; other site 391735004916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735004917 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_5; cd06313 391735004918 putative ligand binding site [chemical binding]; other site 391735004919 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735004920 TM-ABC transporter signature motif; other site 391735004921 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735004922 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735004923 Walker A/P-loop; other site 391735004924 ATP binding site [chemical binding]; other site 391735004925 Q-loop/lid; other site 391735004926 ABC transporter signature motif; other site 391735004927 Walker B; other site 391735004928 D-loop; other site 391735004929 H-loop/switch region; other site 391735004930 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735004931 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735004932 TM-ABC transporter signature motif; other site 391735004933 Predicted dehydrogenase [General function prediction only]; Region: COG0579 391735004934 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735004935 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 391735004936 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391735004937 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 391735004938 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 391735004939 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 391735004940 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391735004941 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735004942 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 391735004943 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 391735004944 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391735004945 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735004946 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 391735004947 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 391735004948 carboxyltransferase (CT) interaction site; other site 391735004949 biotinylation site [posttranslational modification]; other site 391735004950 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 391735004951 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735004952 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735004953 acyl-CoA synthetase; Validated; Region: PRK06178 391735004954 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735004955 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391735004956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735004957 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735004958 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 391735004959 putative ligand binding site [chemical binding]; other site 391735004960 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 391735004961 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 391735004962 tetramer interface [polypeptide binding]; other site 391735004963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735004964 catalytic residue [active] 391735004965 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 391735004966 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391735004967 catalytic residue [active] 391735004968 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 391735004969 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 391735004970 Walker A motif; other site 391735004971 ATP binding site [chemical binding]; other site 391735004972 Walker B motif; other site 391735004973 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391735004974 ligand binding site [chemical binding]; other site 391735004975 flexible hinge region; other site 391735004976 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 391735004977 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735004978 Walker A motif; other site 391735004979 ATP binding site [chemical binding]; other site 391735004980 Walker B motif; other site 391735004981 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391735004982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735004983 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 391735004984 putative metal binding site [ion binding]; other site 391735004985 Predicted membrane protein [Function unknown]; Region: COG4125 391735004986 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 391735004987 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 391735004988 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 391735004989 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 391735004990 active site 391735004991 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 391735004992 UvrD/REP helicase; Region: UvrD-helicase; cl14126 391735004993 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391735004994 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735004995 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 391735004996 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 391735004997 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 391735004998 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 391735004999 NAD(P) binding site [chemical binding]; other site 391735005000 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 391735005001 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391735005002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735005003 hypothetical protein; Provisional; Region: PRK07483 391735005004 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 391735005005 inhibitor-cofactor binding pocket; inhibition site 391735005006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735005007 catalytic residue [active] 391735005008 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 391735005009 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735005010 substrate binding pocket [chemical binding]; other site 391735005011 membrane-bound complex binding site; other site 391735005012 hinge residues; other site 391735005013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735005014 dimer interface [polypeptide binding]; other site 391735005015 conserved gate region; other site 391735005016 putative PBP binding loops; other site 391735005017 ABC-ATPase subunit interface; other site 391735005018 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 391735005019 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 391735005020 Walker A/P-loop; other site 391735005021 ATP binding site [chemical binding]; other site 391735005022 Q-loop/lid; other site 391735005023 ABC transporter signature motif; other site 391735005024 Walker B; other site 391735005025 D-loop; other site 391735005026 H-loop/switch region; other site 391735005027 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 391735005028 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 391735005029 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 391735005030 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 391735005031 active site 391735005032 metal binding site [ion binding]; metal-binding site 391735005033 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 391735005034 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 391735005035 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 391735005036 Membrane transport protein; Region: Mem_trans; cl09117 391735005037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735005038 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735005039 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 391735005040 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 391735005041 Int/Topo IB signature motif; other site 391735005042 active site 391735005043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735005044 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735005045 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 391735005046 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 391735005047 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 391735005048 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 391735005049 trimer interface [polypeptide binding]; other site 391735005050 putative metal binding site [ion binding]; other site 391735005051 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 391735005052 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391735005053 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 391735005054 FeS/SAM binding site; other site 391735005055 TRAM domain; Region: TRAM; cl01282 391735005056 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 391735005057 UreF; Region: UreF; pfam01730 391735005058 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 391735005059 UreF; Region: UreF; pfam01730 391735005060 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The C-...; Region: UreE; cd00571 391735005061 dimer interface [polypeptide binding]; other site 391735005062 catalytic residues [active] 391735005063 urease subunit alpha; Reviewed; Region: ureC; PRK13207 391735005064 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 391735005065 subunit interactions [polypeptide binding]; other site 391735005066 active site 391735005067 flap region; other site 391735005068 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 391735005069 gamma-beta subunit interface [polypeptide binding]; other site 391735005070 alpha-beta subunit interface [polypeptide binding]; other site 391735005071 HupE / UreJ protein; Region: HupE_UreJ; cl01011 391735005072 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 391735005073 alpha-gamma subunit interface [polypeptide binding]; other site 391735005074 beta-gamma subunit interface [polypeptide binding]; other site 391735005075 Sodium:solute symporter family; Region: SSF; cl00456 391735005076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 391735005077 dimer interface [polypeptide binding]; other site 391735005078 phosphorylation site [posttranslational modification] 391735005079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735005080 ATP binding site [chemical binding]; other site 391735005081 Mg2+ binding site [ion binding]; other site 391735005082 G-X-G motif; other site 391735005083 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391735005084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735005085 active site 391735005086 phosphorylation site [posttranslational modification] 391735005087 intermolecular recognition site; other site 391735005088 dimerization interface [polypeptide binding]; other site 391735005089 Response regulator receiver domain; Region: Response_reg; pfam00072 391735005090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735005091 active site 391735005092 phosphorylation site [posttranslational modification] 391735005093 intermolecular recognition site; other site 391735005094 dimerization interface [polypeptide binding]; other site 391735005095 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 391735005096 DNA binding residues [nucleotide binding] 391735005097 dimerization interface [polypeptide binding]; other site 391735005098 Protein of unknown function (DUF3334); Region: DUF3334; pfam11813 391735005099 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 391735005100 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735005101 FAD binding site [chemical binding]; other site 391735005102 substrate binding pocket [chemical binding]; other site 391735005103 catalytic base [active] 391735005104 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735005105 FemAB family; Region: FemAB; cl11444 391735005106 Protein of unknown function, DUF482; Region: DUF482; pfam04339 391735005107 NAD synthetase; Provisional; Region: PRK13981 391735005108 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 391735005109 multimer interface [polypeptide binding]; other site 391735005110 active site 391735005111 catalytic triad [active] 391735005112 protein interface 1 [polypeptide binding]; other site 391735005113 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 391735005114 homodimer interface [polypeptide binding]; other site 391735005115 NAD binding pocket [chemical binding]; other site 391735005116 ATP binding pocket [chemical binding]; other site 391735005117 Mg binding site [ion binding]; other site 391735005118 active-site loop [active] 391735005119 Nitrogen regulatory protein P-II; Region: P-II; cl00412 391735005120 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 391735005121 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 391735005122 RDD family; Region: RDD; cl00746 391735005123 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 391735005124 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 391735005125 RNA polymerase factor sigma-70; Validated; Region: PRK09047 391735005126 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 391735005127 DNA binding residues [nucleotide binding] 391735005128 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 391735005129 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391735005130 PYR/PP interface [polypeptide binding]; other site 391735005131 dimer interface [polypeptide binding]; other site 391735005132 TPP binding site [chemical binding]; other site 391735005133 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391735005134 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 391735005135 TPP-binding site [chemical binding]; other site 391735005136 dimer interface [polypeptide binding]; other site 391735005137 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 391735005138 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 391735005139 putative valine binding site [chemical binding]; other site 391735005140 dimer interface [polypeptide binding]; other site 391735005141 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 391735005142 ketol-acid reductoisomerase; Provisional; Region: PRK05479 391735005143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735005144 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 391735005145 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 391735005146 Virulence protein [General function prediction only]; Region: COG3943 391735005147 Protein of unknown function (DUF1016); Region: DUF1016; cl01979 391735005148 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 391735005149 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735005150 ATP binding site [chemical binding]; other site 391735005151 putative Mg++ binding site [ion binding]; other site 391735005152 T5orf172 domain; Region: T5orf172; pfam10544 391735005153 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 391735005154 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 391735005155 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 391735005156 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 391735005157 Walker A motif; other site 391735005158 ATP binding site [chemical binding]; other site 391735005159 Walker B motif; other site 391735005160 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 391735005161 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 391735005162 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 391735005163 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735005164 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735005165 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 391735005166 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 391735005167 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 391735005168 recombination factor protein RarA; Reviewed; Region: PRK13342 391735005169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735005170 Walker A motif; other site 391735005171 ATP binding site [chemical binding]; other site 391735005172 Walker B motif; other site 391735005173 arginine finger; other site 391735005174 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 391735005175 aspartate aminotransferase; Provisional; Region: PRK08361 391735005176 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391735005177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735005178 homodimer interface [polypeptide binding]; other site 391735005179 catalytic residue [active] 391735005180 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 391735005181 Response regulator receiver domain; Region: Response_reg; pfam00072 391735005182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735005183 active site 391735005184 phosphorylation site [posttranslational modification] 391735005185 intermolecular recognition site; other site 391735005186 dimerization interface [polypeptide binding]; other site 391735005187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735005188 active site 391735005189 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 391735005190 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735005191 catalytic loop [active] 391735005192 iron binding site [ion binding]; other site 391735005193 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD...; Region: flavin_oxioreductase; cd06189 391735005194 FAD binding pocket [chemical binding]; other site 391735005195 FAD binding motif [chemical binding]; other site 391735005196 phosphate binding motif [ion binding]; other site 391735005197 beta-alpha-beta structure motif; other site 391735005198 NAD binding pocket [chemical binding]; other site 391735005199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735005200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735005201 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 391735005202 catalytic center binding site [active] 391735005203 ATP binding site [chemical binding]; other site 391735005204 poly(A) polymerase; Region: pcnB; TIGR01942 391735005205 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 391735005206 active site 391735005207 NTP binding site [chemical binding]; other site 391735005208 metal binding triad [ion binding]; metal-binding site 391735005209 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 391735005210 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 391735005211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 391735005212 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735005213 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 391735005214 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 391735005215 dimerization interface [polypeptide binding]; other site 391735005216 putative ATP binding site [chemical binding]; other site 391735005217 Domain of unknown function DUF20; Region: UPF0118; cl00465 391735005218 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 391735005219 Uncharacterized conserved protein [Function unknown]; Region: COG2912 391735005220 hypothetical protein; Provisional; Region: PRK10941 391735005221 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 391735005222 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 391735005223 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 391735005224 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 391735005225 putative active site [active] 391735005226 transaldolase-like protein; Provisional; Region: PTZ00411 391735005227 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 391735005228 active site 391735005229 dimer interface [polypeptide binding]; other site 391735005230 catalytic residue [active] 391735005231 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 391735005232 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 391735005233 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 391735005234 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 391735005235 protein binding site [polypeptide binding]; other site 391735005236 Uncharacterized conserved protein [Function unknown]; Region: COG0327 391735005237 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 391735005238 Transposase domain (DUF772); Region: DUF772; cl12084 391735005239 Protein of unknown function (DUF519); Region: DUF519; cl04492 391735005240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391735005241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735005242 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735005243 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735005244 active site 391735005245 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 391735005246 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391735005247 dimer interface [polypeptide binding]; other site 391735005248 active site 391735005249 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735005250 fatty oxidation complex, alpha subunit FadB; Region: FadB; TIGR02437 391735005251 substrate binding site [chemical binding]; other site 391735005252 oxyanion hole (OAH) forming residues; other site 391735005253 trimer interface [polypeptide binding]; other site 391735005254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735005255 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391735005256 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391735005257 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735005258 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735005259 Walker A/P-loop; other site 391735005260 ATP binding site [chemical binding]; other site 391735005261 Q-loop/lid; other site 391735005262 ABC transporter signature motif; other site 391735005263 Walker B; other site 391735005264 D-loop; other site 391735005265 H-loop/switch region; other site 391735005266 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735005267 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735005268 Walker A/P-loop; other site 391735005269 ATP binding site [chemical binding]; other site 391735005270 Q-loop/lid; other site 391735005271 ABC transporter signature motif; other site 391735005272 Walker B; other site 391735005273 D-loop; other site 391735005274 H-loop/switch region; other site 391735005275 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735005276 TM-ABC transporter signature motif; other site 391735005277 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735005278 TM-ABC transporter signature motif; other site 391735005279 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735005280 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 391735005281 putative ligand binding site [chemical binding]; other site 391735005282 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735005283 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 391735005284 putative ligand binding site [chemical binding]; other site 391735005285 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735005286 putative acyl-CoA synthetase; Provisional; Region: PRK06018 391735005287 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 391735005288 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 391735005289 SelR domain; Region: SelR; cl00369 391735005290 Intracellular septation protein A; Region: IspA; cl01098 391735005291 BolA-like protein; Region: BolA; cl00386 391735005292 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 391735005293 PPIC-type PPIASE domain; Region: Rotamase; cl08278 391735005294 Sulfate transporter family; Region: Sulfate_transp; cl00967 391735005295 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391735005296 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735005297 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 391735005298 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735005299 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 391735005300 active site 391735005301 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735005302 Bacterial transcriptional regulator; Region: IclR; pfam01614 391735005303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735005304 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735005305 lipid-transfer protein; Provisional; Region: PRK08256 391735005306 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 391735005307 active site 391735005308 enoyl-CoA hydratase; Provisional; Region: PRK07657 391735005309 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735005310 substrate binding site [chemical binding]; other site 391735005311 oxyanion hole (OAH) forming residues; other site 391735005312 trimer interface [polypeptide binding]; other site 391735005313 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735005314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735005315 NAD(P) binding site [chemical binding]; other site 391735005316 active site 391735005317 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 391735005318 putative hydrophobic ligand binding site [chemical binding]; other site 391735005319 protein interface [polypeptide binding]; other site 391735005320 gate; other site 391735005321 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 391735005322 metal ion-dependent adhesion site (MIDAS); other site 391735005323 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 391735005324 Protein of unknown function DUF58; Region: DUF58; pfam01882 391735005325 MoxR-like ATPases [General function prediction only]; Region: COG0714 391735005326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735005327 Walker A motif; other site 391735005328 ATP binding site [chemical binding]; other site 391735005329 Walker B motif; other site 391735005330 arginine finger; other site 391735005331 Methanol dehydrogenase beta subunit; Region: MDH; pfam02315 391735005332 Cytochrome c; Region: Cytochrom_C; cl11414 391735005333 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 391735005334 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735005335 membrane-bound complex binding site; other site 391735005336 hinge residues; other site 391735005337 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 391735005338 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cd00216 391735005339 Trp docking motif; other site 391735005340 'Velcro' closure; other site 391735005341 active site 391735005342 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 391735005343 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391735005344 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391735005345 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 391735005346 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391735005347 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 391735005348 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; cl01902 391735005349 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 391735005350 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391735005351 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 391735005352 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 391735005353 SCP-2 sterol transfer family; Region: SCP2; cl01225 391735005354 acyl-CoA synthetase; Validated; Region: PRK06188 391735005355 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735005356 lipid-transfer protein; Provisional; Region: PRK08256 391735005357 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 391735005358 active site 391735005359 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 391735005360 DNA polymerase I; Provisional; Region: PRK05755 391735005361 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 391735005362 active site 391735005363 metal binding site 1 [ion binding]; metal-binding site 391735005364 putative 5' ssDNA interaction site; other site 391735005365 metal binding site 3; metal-binding site 391735005366 metal binding site 2 [ion binding]; metal-binding site 391735005367 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 391735005368 putative DNA binding site [nucleotide binding]; other site 391735005369 putative metal binding site [ion binding]; other site 391735005370 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 391735005371 active site 391735005372 catalytic site [active] 391735005373 substrate binding site [chemical binding]; other site 391735005374 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 391735005375 active site 391735005376 DNA binding site [nucleotide binding] 391735005377 catalytic site [active] 391735005378 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 391735005379 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 391735005380 putative active site [active] 391735005381 ATP binding site [chemical binding]; other site 391735005382 putative substrate binding site [chemical binding]; other site 391735005383 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 391735005384 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 391735005385 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 391735005386 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391735005387 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735005388 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391735005389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735005390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735005391 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391735005392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735005393 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 391735005394 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 391735005395 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391735005396 DNA binding site [nucleotide binding] 391735005397 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391735005398 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 391735005399 putative ligand binding site [chemical binding]; other site 391735005400 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391735005401 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391735005402 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 391735005403 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735005404 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 391735005405 dimerization interface [polypeptide binding]; other site 391735005406 substrate binding pocket [chemical binding]; other site 391735005407 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391735005408 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391735005409 EamA-like transporter family; Region: EamA; cl01037 391735005410 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391735005411 EamA-like transporter family; Region: EamA; cl01037 391735005412 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 391735005413 Uncharacterized conserved protein [Function unknown]; Region: COG3391 391735005414 Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036 391735005415 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 391735005416 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 391735005417 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 391735005418 active site 391735005419 putative substrate binding pocket [chemical binding]; other site 391735005420 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735005421 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391735005422 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735005423 Walker A/P-loop; other site 391735005424 ATP binding site [chemical binding]; other site 391735005425 Q-loop/lid; other site 391735005426 ABC transporter signature motif; other site 391735005427 Walker B; other site 391735005428 D-loop; other site 391735005429 H-loop/switch region; other site 391735005430 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735005431 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735005432 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735005433 Walker A/P-loop; other site 391735005434 ATP binding site [chemical binding]; other site 391735005435 Q-loop/lid; other site 391735005436 ABC transporter signature motif; other site 391735005437 Walker B; other site 391735005438 D-loop; other site 391735005439 H-loop/switch region; other site 391735005440 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735005441 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391735005442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735005443 dimer interface [polypeptide binding]; other site 391735005444 conserved gate region; other site 391735005445 putative PBP binding loops; other site 391735005446 ABC-ATPase subunit interface; other site 391735005447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735005448 dimer interface [polypeptide binding]; other site 391735005449 conserved gate region; other site 391735005450 putative PBP binding loops; other site 391735005451 ABC-ATPase subunit interface; other site 391735005452 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 391735005453 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735005454 Uncharacterized conserved protein [Function unknown]; Region: COG5476 391735005455 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 391735005456 MlrC C-terminus; Region: MlrC_C; pfam07171 391735005457 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735005458 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 391735005459 dimerization interface [polypeptide binding]; other site 391735005460 ligand binding site [chemical binding]; other site 391735005461 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735005462 TM-ABC transporter signature motif; other site 391735005463 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 391735005464 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 391735005465 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735005466 TM-ABC transporter signature motif; other site 391735005467 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 391735005468 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735005469 Walker A/P-loop; other site 391735005470 ATP binding site [chemical binding]; other site 391735005471 Q-loop/lid; other site 391735005472 ABC transporter signature motif; other site 391735005473 Walker B; other site 391735005474 D-loop; other site 391735005475 H-loop/switch region; other site 391735005476 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 391735005477 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735005478 Walker A/P-loop; other site 391735005479 ATP binding site [chemical binding]; other site 391735005480 Q-loop/lid; other site 391735005481 ABC transporter signature motif; other site 391735005482 Walker B; other site 391735005483 D-loop; other site 391735005484 H-loop/switch region; other site 391735005485 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391735005486 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391735005487 DNA binding site [nucleotide binding] 391735005488 domain linker motif; other site 391735005489 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 391735005490 dimerization interface [polypeptide binding]; other site 391735005491 ligand binding site [chemical binding]; other site 391735005492 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391735005493 FAD binding domain; Region: FAD_binding_4; pfam01565 391735005494 D-xylulose kinase; Region: XylB; TIGR01312 391735005495 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 391735005496 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 391735005497 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391735005498 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 391735005499 Walker A/P-loop; other site 391735005500 ATP binding site [chemical binding]; other site 391735005501 Q-loop/lid; other site 391735005502 ABC transporter signature motif; other site 391735005503 Walker B; other site 391735005504 D-loop; other site 391735005505 H-loop/switch region; other site 391735005506 TOBE domain; Region: TOBE_2; cl01440 391735005507 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735005508 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391735005509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735005510 dimer interface [polypeptide binding]; other site 391735005511 conserved gate region; other site 391735005512 putative PBP binding loops; other site 391735005513 ABC-ATPase subunit interface; other site 391735005514 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391735005515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735005516 dimer interface [polypeptide binding]; other site 391735005517 conserved gate region; other site 391735005518 putative PBP binding loops; other site 391735005519 ABC-ATPase subunit interface; other site 391735005520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735005521 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735005522 NAD(P) binding site [chemical binding]; other site 391735005523 active site 391735005524 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 391735005525 dimer interface [polypeptide binding]; other site 391735005526 active site 391735005527 metal binding site [ion binding]; metal-binding site 391735005528 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735005529 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735005530 active site 391735005531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735005532 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735005533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 391735005534 Protein of unknown function (DUF497); Region: DUF497; cl01108 391735005535 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391735005536 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 391735005537 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391735005538 RNA binding surface [nucleotide binding]; other site 391735005539 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 391735005540 active site 391735005541 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 391735005542 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 391735005543 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 391735005544 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 391735005545 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 391735005546 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 391735005547 Peptidase family M48; Region: Peptidase_M48; cl12018 391735005548 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 391735005549 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 391735005550 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391735005551 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735005552 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 391735005553 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 391735005554 carboxyltransferase (CT) interaction site; other site 391735005555 biotinylation site [posttranslational modification]; other site 391735005556 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735005557 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735005558 active site 391735005559 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 391735005560 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735005561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735005562 enoyl-CoA hydratase; Provisional; Region: PRK06688 391735005563 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735005564 substrate binding site [chemical binding]; other site 391735005565 oxyanion hole (OAH) forming residues; other site 391735005566 trimer interface [polypeptide binding]; other site 391735005567 acetylornithine aminotransferase; Provisional; Region: PRK02627 391735005568 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 391735005569 inhibitor-cofactor binding pocket; inhibition site 391735005570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735005571 catalytic residue [active] 391735005572 ornithine carbamoyltransferase; Provisional; Region: PRK00779 391735005573 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 391735005574 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 391735005575 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391735005576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735005577 DNA-binding site [nucleotide binding]; DNA binding site 391735005578 UTRA domain; Region: UTRA; cl06649 391735005579 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735005580 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 391735005581 putative ligand binding site [chemical binding]; other site 391735005582 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735005583 TM-ABC transporter signature motif; other site 391735005584 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735005585 TM-ABC transporter signature motif; other site 391735005586 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735005587 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735005588 Walker A/P-loop; other site 391735005589 ATP binding site [chemical binding]; other site 391735005590 Q-loop/lid; other site 391735005591 ABC transporter signature motif; other site 391735005592 Walker B; other site 391735005593 D-loop; other site 391735005594 H-loop/switch region; other site 391735005595 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735005596 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735005597 Walker A/P-loop; other site 391735005598 ATP binding site [chemical binding]; other site 391735005599 Q-loop/lid; other site 391735005600 ABC transporter signature motif; other site 391735005601 Walker B; other site 391735005602 D-loop; other site 391735005603 H-loop/switch region; other site 391735005604 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735005605 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 391735005606 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 391735005607 substrate binding site [chemical binding]; other site 391735005608 ligand binding site [chemical binding]; other site 391735005609 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 391735005610 substrate binding site [chemical binding]; other site 391735005611 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 391735005612 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 391735005613 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391735005614 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 391735005615 Isochorismatase family; Region: Isochorismatase; pfam00857 391735005616 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 391735005617 catalytic triad [active] 391735005618 conserved cis-peptide bond; other site 391735005619 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 391735005620 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735005621 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735005622 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 391735005623 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 391735005624 tetramer interface [polypeptide binding]; other site 391735005625 active site 391735005626 Mg2+/Mn2+ binding site [ion binding]; other site 391735005627 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391735005628 E3 interaction surface; other site 391735005629 lipoyl attachment site [posttranslational modification]; other site 391735005630 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735005631 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 391735005632 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391735005633 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391735005634 E3 interaction surface; other site 391735005635 lipoyl attachment site [posttranslational modification]; other site 391735005636 e3 binding domain; Region: E3_binding; pfam02817 391735005637 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 391735005638 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 391735005639 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 391735005640 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 391735005641 dimer interface [polypeptide binding]; other site 391735005642 TPP-binding site [chemical binding]; other site 391735005643 PAS domain S-box; Region: sensory_box; TIGR00229 391735005644 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391735005645 putative active site [active] 391735005646 heme pocket [chemical binding]; other site 391735005647 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 391735005648 dimer interface [polypeptide binding]; other site 391735005649 phosphorylation site [posttranslational modification] 391735005650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735005651 ATP binding site [chemical binding]; other site 391735005652 Mg2+ binding site [ion binding]; other site 391735005653 G-X-G motif; other site 391735005654 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 391735005655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735005656 active site 391735005657 phosphorylation site [posttranslational modification] 391735005658 intermolecular recognition site; other site 391735005659 dimerization interface [polypeptide binding]; other site 391735005660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 391735005661 DNA binding residues [nucleotide binding] 391735005662 dimerization interface [polypeptide binding]; other site 391735005663 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 391735005664 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 391735005665 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 391735005666 homodimer interface [polypeptide binding]; other site 391735005667 NADP binding site [chemical binding]; other site 391735005668 substrate binding site [chemical binding]; other site 391735005669 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 391735005670 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 391735005671 active site 391735005672 Zn binding site [ion binding]; other site 391735005673 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 391735005674 catalytic residues [active] 391735005675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 391735005676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735005677 dimer interface [polypeptide binding]; other site 391735005678 conserved gate region; other site 391735005679 putative PBP binding loops; other site 391735005680 ABC-ATPase subunit interface; other site 391735005681 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391735005682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735005683 dimer interface [polypeptide binding]; other site 391735005684 conserved gate region; other site 391735005685 putative PBP binding loops; other site 391735005686 ABC-ATPase subunit interface; other site 391735005687 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391735005688 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735005689 substrate binding pocket [chemical binding]; other site 391735005690 membrane-bound complex binding site; other site 391735005691 hinge residues; other site 391735005692 Uncharacterized conserved protein [Function unknown]; Region: COG5476 391735005693 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 391735005694 MlrC C-terminus; Region: MlrC_C; pfam07171 391735005695 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735005696 Q-loop/lid; other site 391735005697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735005698 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735005699 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 391735005700 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 391735005701 hypothetical protein; Validated; Region: PRK07586 391735005702 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391735005703 PYR/PP interface [polypeptide binding]; other site 391735005704 dimer interface [polypeptide binding]; other site 391735005705 TPP binding site [chemical binding]; other site 391735005706 TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This...; Region: TPP_BFDC; cd02002 391735005707 TPP-binding site [chemical binding]; other site 391735005708 dimer interface [polypeptide binding]; other site 391735005709 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 391735005710 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391735005711 active site 391735005712 dimer interface [polypeptide binding]; other site 391735005713 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 391735005714 quinone interaction residues [chemical binding]; other site 391735005715 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 391735005716 active site 391735005717 catalytic residues [active] 391735005718 FMN binding site [chemical binding]; other site 391735005719 substrate binding site [chemical binding]; other site 391735005720 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 391735005721 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391735005722 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735005723 NAD(P) binding site [chemical binding]; other site 391735005724 catalytic residues [active] 391735005725 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 391735005726 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 391735005727 choline dehydrogenase; Validated; Region: PRK02106 391735005728 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391735005729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735005730 dimer interface [polypeptide binding]; other site 391735005731 conserved gate region; other site 391735005732 putative PBP binding loops; other site 391735005733 ABC-ATPase subunit interface; other site 391735005734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735005735 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391735005736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735005737 putative PBP binding loops; other site 391735005738 dimer interface [polypeptide binding]; other site 391735005739 ABC-ATPase subunit interface; other site 391735005740 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391735005741 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735005742 Walker A/P-loop; other site 391735005743 ATP binding site [chemical binding]; other site 391735005744 Q-loop/lid; other site 391735005745 ABC transporter signature motif; other site 391735005746 Walker B; other site 391735005747 D-loop; other site 391735005748 H-loop/switch region; other site 391735005749 TOBE domain; Region: TOBE_2; cl01440 391735005750 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 391735005751 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 391735005752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735005753 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735005754 TM-ABC transporter signature motif; other site 391735005755 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735005756 TM-ABC transporter signature motif; other site 391735005757 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735005758 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735005759 Walker A/P-loop; other site 391735005760 ATP binding site [chemical binding]; other site 391735005761 Q-loop/lid; other site 391735005762 ABC transporter signature motif; other site 391735005763 Walker B; other site 391735005764 D-loop; other site 391735005765 H-loop/switch region; other site 391735005766 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735005767 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735005768 Walker A/P-loop; other site 391735005769 ATP binding site [chemical binding]; other site 391735005770 Q-loop/lid; other site 391735005771 ABC transporter signature motif; other site 391735005772 Walker B; other site 391735005773 D-loop; other site 391735005774 H-loop/switch region; other site 391735005775 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735005776 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 391735005777 ligand binding site [chemical binding]; other site 391735005778 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 391735005779 phosphate binding site [ion binding]; other site 391735005780 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 391735005781 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 391735005782 putative ligand binding site [chemical binding]; other site 391735005783 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391735005784 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 391735005785 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735005786 Helix-turn-helix domain; Region: HTH_18; pfam12833 391735005787 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391735005788 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 391735005789 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735005790 Putative cyclase; Region: Cyclase; cl00814 391735005791 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 391735005792 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 391735005793 dimer interface [polypeptide binding]; other site 391735005794 PYR/PP interface [polypeptide binding]; other site 391735005795 TPP binding site [chemical binding]; other site 391735005796 substrate binding site [chemical binding]; other site 391735005797 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 391735005798 TPP-binding site [chemical binding]; other site 391735005799 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 391735005800 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 391735005801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735005802 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735005803 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 391735005804 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735005805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735005806 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391735005807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735005808 dimer interface [polypeptide binding]; other site 391735005809 conserved gate region; other site 391735005810 putative PBP binding loops; other site 391735005811 ABC-ATPase subunit interface; other site 391735005812 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735005813 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 391735005814 Walker A/P-loop; other site 391735005815 ATP binding site [chemical binding]; other site 391735005816 Q-loop/lid; other site 391735005817 ABC transporter signature motif; other site 391735005818 Walker B; other site 391735005819 D-loop; other site 391735005820 H-loop/switch region; other site 391735005821 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735005822 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735005823 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 391735005824 Walker A/P-loop; other site 391735005825 ATP binding site [chemical binding]; other site 391735005826 Q-loop/lid; other site 391735005827 ABC transporter signature motif; other site 391735005828 Walker B; other site 391735005829 D-loop; other site 391735005830 H-loop/switch region; other site 391735005831 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735005832 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735005833 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391735005834 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735005835 substrate binding pocket [chemical binding]; other site 391735005836 membrane-bound complex binding site; other site 391735005837 hinge residues; other site 391735005838 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391735005839 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 391735005840 Walker A/P-loop; other site 391735005841 ATP binding site [chemical binding]; other site 391735005842 Q-loop/lid; other site 391735005843 ABC transporter signature motif; other site 391735005844 Walker B; other site 391735005845 D-loop; other site 391735005846 H-loop/switch region; other site 391735005847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735005848 dimer interface [polypeptide binding]; other site 391735005849 conserved gate region; other site 391735005850 putative PBP binding loops; other site 391735005851 ABC-ATPase subunit interface; other site 391735005852 argininosuccinate lyase; Provisional; Region: PRK00855 391735005853 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 391735005854 active sites [active] 391735005855 tetramer interface [polypeptide binding]; other site 391735005856 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391735005857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735005858 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 391735005859 dimerization interface [polypeptide binding]; other site 391735005860 substrate binding pocket [chemical binding]; other site 391735005861 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735005862 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 391735005863 putative ligand binding site [chemical binding]; other site 391735005864 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735005865 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735005866 Walker A/P-loop; other site 391735005867 ATP binding site [chemical binding]; other site 391735005868 Q-loop/lid; other site 391735005869 ABC transporter signature motif; other site 391735005870 Walker B; other site 391735005871 D-loop; other site 391735005872 H-loop/switch region; other site 391735005873 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735005874 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735005875 Walker A/P-loop; other site 391735005876 ATP binding site [chemical binding]; other site 391735005877 Q-loop/lid; other site 391735005878 ABC transporter signature motif; other site 391735005879 Walker B; other site 391735005880 D-loop; other site 391735005881 H-loop/switch region; other site 391735005882 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735005883 TM-ABC transporter signature motif; other site 391735005884 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735005885 TM-ABC transporter signature motif; other site 391735005886 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 391735005887 classical (c) SDRs; Region: SDR_c; cd05233 391735005888 NAD(P) binding site [chemical binding]; other site 391735005889 active site 391735005890 Isochorismatase family; Region: Isochorismatase; pfam00857 391735005891 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 391735005892 catalytic triad [active] 391735005893 conserved cis-peptide bond; other site 391735005894 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 391735005895 inter-subunit interface; other site 391735005896 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 391735005897 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 391735005898 iron-sulfur cluster [ion binding]; other site 391735005899 [2Fe-2S] cluster binding site [ion binding]; other site 391735005900 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 391735005901 putative alpha subunit interface [polypeptide binding]; other site 391735005902 putative active site [active] 391735005903 putative substrate binding site [chemical binding]; other site 391735005904 Fe binding site [ion binding]; other site 391735005905 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391735005906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391735005907 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735005908 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 391735005909 PYR/PP interface [polypeptide binding]; other site 391735005910 TPP binding site [chemical binding]; other site 391735005911 dimer interface [polypeptide binding]; other site 391735005912 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735005913 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 391735005914 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391735005915 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 391735005916 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735005917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735005918 dimer interface [polypeptide binding]; other site 391735005919 conserved gate region; other site 391735005920 putative PBP binding loops; other site 391735005921 ABC-ATPase subunit interface; other site 391735005922 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391735005923 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391735005924 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735005925 Walker A/P-loop; other site 391735005926 ATP binding site [chemical binding]; other site 391735005927 Q-loop/lid; other site 391735005928 ABC transporter signature motif; other site 391735005929 Walker B; other site 391735005930 D-loop; other site 391735005931 H-loop/switch region; other site 391735005932 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735005933 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735005934 Walker A/P-loop; other site 391735005935 ATP binding site [chemical binding]; other site 391735005936 Q-loop/lid; other site 391735005937 ABC transporter signature motif; other site 391735005938 Walker B; other site 391735005939 D-loop; other site 391735005940 H-loop/switch region; other site 391735005941 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735005942 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735005943 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391735005944 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735005945 active site 391735005946 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 391735005947 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735005948 active site 391735005949 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA)...; Region: CCL_ACL-C; cd06100 391735005950 active site 391735005951 oxalacetate binding site [chemical binding]; other site 391735005952 citrylCoA binding site [chemical binding]; other site 391735005953 coenzyme A binding site [chemical binding]; other site 391735005954 catalytic triad [active] 391735005955 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 391735005956 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 391735005957 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391735005958 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735005959 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391735005960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735005961 dimer interface [polypeptide binding]; other site 391735005962 conserved gate region; other site 391735005963 putative PBP binding loops; other site 391735005964 ABC-ATPase subunit interface; other site 391735005965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735005966 dimer interface [polypeptide binding]; other site 391735005967 conserved gate region; other site 391735005968 putative PBP binding loops; other site 391735005969 ABC-ATPase subunit interface; other site 391735005970 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391735005971 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735005972 Walker A/P-loop; other site 391735005973 ATP binding site [chemical binding]; other site 391735005974 Q-loop/lid; other site 391735005975 ABC transporter signature motif; other site 391735005976 Walker B; other site 391735005977 D-loop; other site 391735005978 H-loop/switch region; other site 391735005979 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391735005980 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 391735005981 Walker A/P-loop; other site 391735005982 ATP binding site [chemical binding]; other site 391735005983 Q-loop/lid; other site 391735005984 ABC transporter signature motif; other site 391735005985 Walker B; other site 391735005986 D-loop; other site 391735005987 H-loop/switch region; other site 391735005988 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 391735005989 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 391735005990 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 391735005991 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391735005992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735005993 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 391735005994 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 391735005995 active site 391735005996 intersubunit interface [polypeptide binding]; other site 391735005997 Zn2+ binding site [ion binding]; other site 391735005998 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 391735005999 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 391735006000 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 391735006001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 391735006002 Fic family protein [Function unknown]; Region: COG3177 391735006003 Fic/DOC family; Region: Fic; cl00960 391735006004 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735006005 TM-ABC transporter signature motif; other site 391735006006 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735006007 TM-ABC transporter signature motif; other site 391735006008 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735006009 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735006010 Walker A/P-loop; other site 391735006011 ATP binding site [chemical binding]; other site 391735006012 Q-loop/lid; other site 391735006013 ABC transporter signature motif; other site 391735006014 Walker B; other site 391735006015 D-loop; other site 391735006016 H-loop/switch region; other site 391735006017 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735006018 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391735006019 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 391735006020 putative ligand binding site [chemical binding]; other site 391735006021 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391735006022 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391735006023 DNA binding site [nucleotide binding] 391735006024 domain linker motif; other site 391735006025 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 391735006026 putative dimerization interface [polypeptide binding]; other site 391735006027 putative ligand binding site [chemical binding]; other site 391735006028 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 391735006029 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 391735006030 active site 391735006031 catalytic residues [active] 391735006032 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 391735006033 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 391735006034 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735006035 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 391735006036 oligomeric interface; other site 391735006037 putative active site [active] 391735006038 homodimer interface [polypeptide binding]; other site 391735006039 Phd_YefM; Region: PhdYeFM; cl09153 391735006040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735006041 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 391735006042 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 391735006043 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 391735006044 short chain dehydrogenase; Provisional; Region: PRK06841 391735006045 classical (c) SDRs; Region: SDR_c; cd05233 391735006046 NAD(P) binding site [chemical binding]; other site 391735006047 active site 391735006048 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 391735006049 putative ligand binding site [chemical binding]; other site 391735006050 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735006051 TM-ABC transporter signature motif; other site 391735006052 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735006053 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735006054 Walker A/P-loop; other site 391735006055 ATP binding site [chemical binding]; other site 391735006056 Q-loop/lid; other site 391735006057 ABC transporter signature motif; other site 391735006058 Walker B; other site 391735006059 D-loop; other site 391735006060 H-loop/switch region; other site 391735006061 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735006062 dihydroxyacetone kinase; Provisional; Region: PRK14479 391735006063 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 391735006064 DAK2 domain; Region: Dak2; cl03685 391735006065 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 391735006066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 391735006067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 391735006068 motif II; other site 391735006069 Domain of unknown function (DUF299); Region: DUF299; cl00780 391735006070 phosphoenolpyruvate synthase; Validated; Region: PRK06464 391735006071 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 391735006072 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 391735006073 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 391735006074 Predicted membrane protein [Function unknown]; Region: COG4327; cl01781 391735006075 Sodium:solute symporter family; Region: SSF; cl00456 391735006076 Sodium:solute symporter family; Region: SSF; cl00456 391735006077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735006078 LysE type translocator; Region: LysE; cl00565 391735006079 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735006080 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 391735006081 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 391735006082 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 391735006083 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 391735006084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391735006085 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 391735006086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 391735006087 DNA binding residues [nucleotide binding] 391735006088 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391735006089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735006090 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735006091 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391735006092 dimerization interface [polypeptide binding]; other site 391735006093 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735006094 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735006095 Walker A/P-loop; other site 391735006096 ATP binding site [chemical binding]; other site 391735006097 Q-loop/lid; other site 391735006098 ABC transporter signature motif; other site 391735006099 Walker B; other site 391735006100 D-loop; other site 391735006101 H-loop/switch region; other site 391735006102 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735006103 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391735006104 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735006105 Walker A/P-loop; other site 391735006106 ATP binding site [chemical binding]; other site 391735006107 Q-loop/lid; other site 391735006108 ABC transporter signature motif; other site 391735006109 Walker B; other site 391735006110 D-loop; other site 391735006111 H-loop/switch region; other site 391735006112 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735006113 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391735006114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735006115 dimer interface [polypeptide binding]; other site 391735006116 conserved gate region; other site 391735006117 putative PBP binding loops; other site 391735006118 ABC-ATPase subunit interface; other site 391735006119 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735006120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735006121 dimer interface [polypeptide binding]; other site 391735006122 conserved gate region; other site 391735006123 ABC-ATPase subunit interface; other site 391735006124 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 391735006125 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735006126 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 391735006127 active site 391735006128 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 391735006129 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: PncB_like; cd01401 391735006130 active site 391735006131 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 391735006132 glyoxylate reductase; Reviewed; Region: PRK13243 391735006133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735006134 RmuC family; Region: RmuC; pfam02646 391735006135 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391735006136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735006137 putative substrate translocation pore; other site 391735006138 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 391735006139 intersubunit interface [polypeptide binding]; other site 391735006140 active site 391735006141 Zn2+ binding site [ion binding]; other site 391735006142 benzoate transport; Region: 2A0115; TIGR00895 391735006143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735006144 putative substrate translocation pore; other site 391735006145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735006146 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735006147 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735006148 NAD(P) binding site [chemical binding]; other site 391735006149 active site 391735006150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 391735006151 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 391735006152 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 391735006153 motif II; other site 391735006154 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 391735006155 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 391735006156 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 391735006157 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735006158 TM-ABC transporter signature motif; other site 391735006159 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735006160 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735006161 Walker A/P-loop; other site 391735006162 ATP binding site [chemical binding]; other site 391735006163 Q-loop/lid; other site 391735006164 ABC transporter signature motif; other site 391735006165 Walker B; other site 391735006166 D-loop; other site 391735006167 H-loop/switch region; other site 391735006168 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735006169 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391735006170 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318 391735006171 putative ligand binding site [chemical binding]; other site 391735006172 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 391735006173 Cupin domain; Region: Cupin_2; cl09118 391735006174 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 391735006175 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391735006176 FAD binding domain; Region: FAD_binding_4; pfam01565 391735006177 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 391735006178 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 391735006179 putative active site [active] 391735006180 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 391735006181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735006182 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 391735006183 putative dimerization interface [polypeptide binding]; other site 391735006184 tricarballylate dehydrogenase; Validated; Region: PRK08274 391735006185 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735006186 tricarballylate utilization protein B; Provisional; Region: PRK15033 391735006187 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 391735006188 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735006189 NAD(P) binding site [chemical binding]; other site 391735006190 catalytic residues [active] 391735006191 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391735006192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735006193 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 391735006194 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 391735006195 FMN binding site [chemical binding]; other site 391735006196 substrate binding site [chemical binding]; other site 391735006197 putative catalytic residue [active] 391735006198 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 391735006199 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 391735006200 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735006201 active site 391735006202 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 391735006203 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 391735006204 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 391735006205 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 391735006206 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 391735006207 Ligand binding site [chemical binding]; other site 391735006208 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 391735006209 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 391735006210 MoxR-like ATPases [General function prediction only]; Region: COG0714 391735006211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735006212 Walker A motif; other site 391735006213 ATP binding site [chemical binding]; other site 391735006214 Walker B motif; other site 391735006215 arginine finger; other site 391735006216 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735006217 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 391735006218 Protein of unknown function DUF58; Region: DUF58; pfam01882 391735006219 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 391735006220 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 391735006221 lytic murein transglycosylase; Region: MltB_2; TIGR02283 391735006222 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 391735006223 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391735006224 ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563 391735006225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735006226 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 391735006227 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 391735006228 active site 391735006229 substrate binding site [chemical binding]; other site 391735006230 cosubstrate binding site; other site 391735006231 catalytic site [active] 391735006232 hypothetical protein; Provisional; Region: PRK11239 391735006233 Protein of unknown function, DUF480; Region: DUF480; cl01209 391735006234 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 391735006235 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735006236 active site 391735006237 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 391735006238 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 391735006239 active site 391735006240 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 391735006241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 391735006242 TPR motif; other site 391735006243 binding surface 391735006244 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 391735006245 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 391735006246 active site 391735006247 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 391735006248 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 391735006249 active site 391735006250 Riboflavin kinase; Region: Flavokinase; pfam01687 391735006251 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 391735006252 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391735006253 active site 391735006254 HIGH motif; other site 391735006255 nucleotide binding site [chemical binding]; other site 391735006256 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 391735006257 active site 391735006258 KMSKS motif; other site 391735006259 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 391735006260 tRNA binding surface [nucleotide binding]; other site 391735006261 anticodon binding site; other site 391735006262 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 391735006263 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 391735006264 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 391735006265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735006266 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735006267 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735006268 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 391735006269 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 391735006270 putative dimerization interface [polypeptide binding]; other site 391735006271 short chain dehydrogenase; Validated; Region: PRK08324 391735006272 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 391735006273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735006274 NAD(P) binding site [chemical binding]; other site 391735006275 active site 391735006276 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 391735006277 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 391735006278 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391735006279 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 391735006280 ligand binding site [chemical binding]; other site 391735006281 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735006282 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735006283 Walker A/P-loop; other site 391735006284 ATP binding site [chemical binding]; other site 391735006285 Q-loop/lid; other site 391735006286 ABC transporter signature motif; other site 391735006287 Walker B; other site 391735006288 D-loop; other site 391735006289 H-loop/switch region; other site 391735006290 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735006291 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735006292 TM-ABC transporter signature motif; other site 391735006293 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735006294 TM-ABC transporter signature motif; other site 391735006295 Domain of unknown function (DUF718); Region: DUF718; cl01281 391735006296 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 391735006297 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase); Region: Rhizopine-oxygenase-like; cd03511 391735006298 Fatty acid desaturase; Region: FA_desaturase; pfam00487 391735006299 putative di-iron ligands [ion binding]; other site 391735006300 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 391735006301 [2Fe-2S] cluster binding site [ion binding]; other site 391735006302 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+...; Region: NADH_quinone_reductase; cd06188 391735006303 FAD binding pocket [chemical binding]; other site 391735006304 FAD binding motif [chemical binding]; other site 391735006305 phosphate binding motif [ion binding]; other site 391735006306 beta-alpha-beta structure motif; other site 391735006307 NAD binding pocket [chemical binding]; other site 391735006308 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391735006309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735006310 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391735006311 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 391735006312 Walker A/P-loop; other site 391735006313 ATP binding site [chemical binding]; other site 391735006314 Q-loop/lid; other site 391735006315 ABC transporter signature motif; other site 391735006316 Walker B; other site 391735006317 D-loop; other site 391735006318 H-loop/switch region; other site 391735006319 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391735006320 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735006321 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 391735006322 substrate binding site [chemical binding]; other site 391735006323 ATP binding site [chemical binding]; other site 391735006324 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735006325 TM-ABC transporter signature motif; other site 391735006326 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735006327 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735006328 Walker A/P-loop; other site 391735006329 ATP binding site [chemical binding]; other site 391735006330 Q-loop/lid; other site 391735006331 ABC transporter signature motif; other site 391735006332 Walker B; other site 391735006333 D-loop; other site 391735006334 H-loop/switch region; other site 391735006335 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735006336 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391735006337 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391735006338 ligand binding site [chemical binding]; other site 391735006339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735006340 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 391735006341 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH)...; Region: pro_PheOH; cd03348 391735006342 cofactor binding site; other site 391735006343 metal binding site [ion binding]; metal-binding site 391735006344 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 391735006345 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 391735006346 dimer interface [polypeptide binding]; other site 391735006347 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 391735006348 active site 391735006349 Fe binding site [ion binding]; other site 391735006350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 391735006351 AzlC protein; Region: AzlC; cl00570 391735006352 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 391735006353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735006354 putative substrate translocation pore; other site 391735006355 phosphonate metabolism-associated iron-containing alcohol dehydrogenase; Region: Phn_Fe-ADH; TIGR03405 391735006356 Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182 391735006357 putative active site [active] 391735006358 metal binding site [ion binding]; metal-binding site 391735006359 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735006360 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 391735006361 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391735006362 dimerization interface [polypeptide binding]; other site 391735006363 hypothetical protein; Provisional; Region: PRK07482 391735006364 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 391735006365 inhibitor-cofactor binding pocket; inhibition site 391735006366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735006367 catalytic residue [active] 391735006368 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735006369 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391735006370 tetramerization interface [polypeptide binding]; other site 391735006371 NAD(P) binding site [chemical binding]; other site 391735006372 catalytic residues [active] 391735006373 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391735006374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735006375 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 391735006376 A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the...; Region: M14_ASTE_ASPA_like_2; cd06252 391735006377 putative active site [active] 391735006378 Zn-binding site [ion binding]; other site 391735006379 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 391735006380 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391735006381 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 391735006382 active site 391735006383 ectoine utilization protein EutC; Validated; Region: PRK08291 391735006384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735006385 NAD(P) binding pocket [chemical binding]; other site 391735006386 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 391735006387 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391735006388 tetramer interface [polypeptide binding]; other site 391735006389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735006390 catalytic residue [active] 391735006391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735006392 DNA-binding site [nucleotide binding]; DNA binding site 391735006393 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391735006394 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391735006395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735006396 homodimer interface [polypeptide binding]; other site 391735006397 catalytic residue [active] 391735006398 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 391735006399 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735006400 substrate binding pocket [chemical binding]; other site 391735006401 membrane-bound complex binding site; other site 391735006402 hinge residues; other site 391735006403 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391735006404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735006405 dimer interface [polypeptide binding]; other site 391735006406 conserved gate region; other site 391735006407 putative PBP binding loops; other site 391735006408 ABC-ATPase subunit interface; other site 391735006409 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391735006410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735006411 dimer interface [polypeptide binding]; other site 391735006412 conserved gate region; other site 391735006413 putative PBP binding loops; other site 391735006414 ABC-ATPase subunit interface; other site 391735006415 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 391735006416 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 391735006417 Walker A/P-loop; other site 391735006418 ATP binding site [chemical binding]; other site 391735006419 Q-loop/lid; other site 391735006420 ABC transporter signature motif; other site 391735006421 Walker B; other site 391735006422 D-loop; other site 391735006423 H-loop/switch region; other site 391735006424 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 391735006425 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 391735006426 Transporter associated domain; Region: CorC_HlyC; pfam03471 391735006427 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 391735006428 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 391735006429 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 391735006430 putative active site [active] 391735006431 catalytic triad [active] 391735006432 putative dimer interface [polypeptide binding]; other site 391735006433 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 391735006434 dimer interface [polypeptide binding]; other site 391735006435 active site 1 [active] 391735006436 active site 2 [active] 391735006437 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 391735006438 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391735006439 dimer interface [polypeptide binding]; other site 391735006440 active site 391735006441 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 391735006442 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 391735006443 dimer interface [polypeptide binding]; other site 391735006444 motif 1; other site 391735006445 active site 391735006446 motif 2; other site 391735006447 motif 3; other site 391735006448 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 391735006449 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 391735006450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 391735006451 active site 391735006452 motif I; other site 391735006453 motif II; other site 391735006454 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391735006455 putative acyl-acceptor binding pocket; other site 391735006456 Protein of unknown function DUF45; Region: DUF45; cl00636 391735006457 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 391735006458 active site residue [active] 391735006459 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 391735006460 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 391735006461 ABC transporter ATPase component; Reviewed; Region: PRK11147 391735006462 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735006463 Walker A/P-loop; other site 391735006464 ATP binding site [chemical binding]; other site 391735006465 Q-loop/lid; other site 391735006466 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 391735006467 ABC transporter; Region: ABC_tran_2; pfam12848 391735006468 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 391735006469 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 391735006470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735006471 active site 391735006472 phosphorylation site [posttranslational modification] 391735006473 intermolecular recognition site; other site 391735006474 dimerization interface [polypeptide binding]; other site 391735006475 CheB methylesterase; Region: CheB_methylest; pfam01339 391735006476 CheD chemotactic sensory transduction; Region: CheD; cl00810 391735006477 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 391735006478 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 391735006479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735006480 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 391735006481 putative CheA interaction surface; other site 391735006482 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 391735006483 putative binding surface; other site 391735006484 active site 391735006485 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 391735006486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735006487 ATP binding site [chemical binding]; other site 391735006488 Mg2+ binding site [ion binding]; other site 391735006489 G-X-G motif; other site 391735006490 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 391735006491 Response regulator receiver domain; Region: Response_reg; pfam00072 391735006492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735006493 active site 391735006494 phosphorylation site [posttranslational modification] 391735006495 intermolecular recognition site; other site 391735006496 dimerization interface [polypeptide binding]; other site 391735006497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735006498 active site 391735006499 phosphorylation site [posttranslational modification] 391735006500 intermolecular recognition site; other site 391735006501 dimerization interface [polypeptide binding]; other site 391735006502 Histidine kinase; Region: HisKA_3; pfam07730 391735006503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735006504 ATP binding site [chemical binding]; other site 391735006505 Mg2+ binding site [ion binding]; other site 391735006506 G-X-G motif; other site 391735006507 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391735006508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735006509 active site 391735006510 phosphorylation site [posttranslational modification] 391735006511 intermolecular recognition site; other site 391735006512 dimerization interface [polypeptide binding]; other site 391735006513 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 391735006514 DNA binding residues [nucleotide binding] 391735006515 dimerization interface [polypeptide binding]; other site 391735006516 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391735006517 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 391735006518 putative C-terminal domain interface [polypeptide binding]; other site 391735006519 putative GSH binding site (G-site) [chemical binding]; other site 391735006520 putative dimer interface [polypeptide binding]; other site 391735006521 GST_C family, unknown subfamily 6; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_C_6; cd03205 391735006522 putative N-terminal domain interface [polypeptide binding]; other site 391735006523 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735006524 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 391735006525 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735006526 classical (c) SDRs; Region: SDR_c; cd05233 391735006527 NAD(P) binding site [chemical binding]; other site 391735006528 active site 391735006529 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 391735006530 DctM-like transporters; Region: DctM; pfam06808 391735006531 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 391735006532 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391735006533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735006534 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735006535 NAD(P) binding site [chemical binding]; other site 391735006536 active site 391735006537 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391735006538 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735006539 DNA-binding site [nucleotide binding]; DNA binding site 391735006540 FCD domain; Region: FCD; cl11656 391735006541 NeuB family; Region: NeuB; cl00496 391735006542 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 391735006543 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 391735006544 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 391735006545 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 391735006546 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 391735006547 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 391735006548 O-Antigen ligase; Region: Wzy_C; cl04850 391735006549 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 391735006550 Exoribonuclease R [Transcription]; Region: VacB; COG0557 391735006551 RNB domain; Region: RNB; pfam00773 391735006552 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 391735006553 Gram-negative bacterial tonB protein; Region: TonB; cl10048 391735006554 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 391735006555 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 391735006556 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 391735006557 shikimate binding site; other site 391735006558 NAD(P) binding site [chemical binding]; other site 391735006559 Transglycosylase; Region: Transgly; cl07896 391735006560 Integrase core domain; Region: rve; cl01316 391735006561 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 391735006562 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391735006563 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391735006564 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 391735006565 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391735006566 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735006567 enoyl-CoA hydratase; Provisional; Region: PRK05995 391735006568 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735006569 substrate binding site [chemical binding]; other site 391735006570 oxyanion hole (OAH) forming residues; other site 391735006571 trimer interface [polypeptide binding]; other site 391735006572 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735006573 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735006574 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735006575 active site 391735006576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735006577 NAD(P) binding site [chemical binding]; other site 391735006578 active site 391735006579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735006580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735006581 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735006582 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735006583 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391735006584 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735006585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735006586 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 391735006587 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735006588 active site 391735006589 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 391735006590 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 391735006591 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 391735006592 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 391735006593 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 391735006594 P-loop; other site 391735006595 active site 391735006596 phosphorylation site [posttranslational modification] 391735006597 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 391735006598 active site 391735006599 phosphorylation site [posttranslational modification] 391735006600 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 391735006601 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 391735006602 dimerization domain swap beta strand [polypeptide binding]; other site 391735006603 regulatory protein interface [polypeptide binding]; other site 391735006604 active site 391735006605 regulatory phosphorylation site [posttranslational modification]; other site 391735006606 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 391735006607 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 391735006608 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 391735006609 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 391735006610 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 391735006611 Glucitol operon activator protein (GutM); Region: GutM; cl01890 391735006612 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 391735006613 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391735006614 E3 interaction surface; other site 391735006615 lipoyl attachment site [posttranslational modification]; other site 391735006616 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 391735006617 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391735006618 alpha subunit interface [polypeptide binding]; other site 391735006619 TPP binding site [chemical binding]; other site 391735006620 heterodimer interface [polypeptide binding]; other site 391735006621 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391735006622 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 391735006623 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391735006624 tetramer interface [polypeptide binding]; other site 391735006625 TPP-binding site [chemical binding]; other site 391735006626 heterodimer interface [polypeptide binding]; other site 391735006627 phosphorylation loop region [posttranslational modification] 391735006628 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 391735006629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735006630 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 391735006631 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 391735006632 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 391735006633 EamA-like transporter family; Region: EamA; cl01037 391735006634 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391735006635 EamA-like transporter family; Region: EamA; cl01037 391735006636 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 391735006637 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 391735006638 NADP binding site [chemical binding]; other site 391735006639 dimer interface [polypeptide binding]; other site 391735006640 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 391735006641 nudix motif; other site 391735006642 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 391735006643 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735006644 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735006645 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735006646 Walker A/P-loop; other site 391735006647 ATP binding site [chemical binding]; other site 391735006648 Q-loop/lid; other site 391735006649 ABC transporter signature motif; other site 391735006650 Walker B; other site 391735006651 D-loop; other site 391735006652 H-loop/switch region; other site 391735006653 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735006654 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391735006655 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735006656 Walker A/P-loop; other site 391735006657 ATP binding site [chemical binding]; other site 391735006658 Q-loop/lid; other site 391735006659 ABC transporter signature motif; other site 391735006660 Walker B; other site 391735006661 D-loop; other site 391735006662 H-loop/switch region; other site 391735006663 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735006664 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735006665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735006666 dimer interface [polypeptide binding]; other site 391735006667 conserved gate region; other site 391735006668 putative PBP binding loops; other site 391735006669 ABC-ATPase subunit interface; other site 391735006670 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391735006671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735006672 dimer interface [polypeptide binding]; other site 391735006673 conserved gate region; other site 391735006674 ABC-ATPase subunit interface; other site 391735006675 Sulfatase; Region: Sulfatase; cl10460 391735006676 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391735006677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735006678 dimer interface [polypeptide binding]; other site 391735006679 conserved gate region; other site 391735006680 ABC-ATPase subunit interface; other site 391735006681 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391735006682 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 391735006683 Walker A/P-loop; other site 391735006684 ATP binding site [chemical binding]; other site 391735006685 Q-loop/lid; other site 391735006686 ABC transporter signature motif; other site 391735006687 Walker B; other site 391735006688 D-loop; other site 391735006689 H-loop/switch region; other site 391735006690 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 391735006691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735006692 dimer interface [polypeptide binding]; other site 391735006693 conserved gate region; other site 391735006694 putative PBP binding loops; other site 391735006695 ABC-ATPase subunit interface; other site 391735006696 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735006697 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391735006698 Predicted amidohydrolase [General function prediction only]; Region: COG0388 391735006699 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 391735006700 putative active site [active] 391735006701 catalytic triad [active] 391735006702 putative dimer interface [polypeptide binding]; other site 391735006703 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735006704 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 391735006705 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 391735006706 active site 391735006707 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 391735006708 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735006709 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735006710 substrate binding site [chemical binding]; other site 391735006711 oxyanion hole (OAH) forming residues; other site 391735006712 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 391735006713 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391735006714 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391735006715 conserved cys residue [active] 391735006716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391735006717 NodT family; Region: outer_NodT; TIGR01845 391735006718 Outer membrane efflux protein; Region: OEP; pfam02321 391735006719 Outer membrane efflux protein; Region: OEP; pfam02321 391735006720 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 391735006721 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 391735006722 elongation factor Tu; Reviewed; Region: PRK00049 391735006723 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 391735006724 G1 box; other site 391735006725 GEF interaction site [polypeptide binding]; other site 391735006726 GTP/Mg2+ binding site [chemical binding]; other site 391735006727 Switch I region; other site 391735006728 G2 box; other site 391735006729 G3 box; other site 391735006730 Switch II region; other site 391735006731 G4 box; other site 391735006732 G5 box; other site 391735006733 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 391735006734 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 391735006735 Antibiotic Binding Site [chemical binding]; other site 391735006736 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 391735006737 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 391735006738 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 391735006739 putative homodimer interface [polypeptide binding]; other site 391735006740 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 391735006741 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 391735006742 23S rRNA interface [nucleotide binding]; other site 391735006743 L7/L12 interface [polypeptide binding]; other site 391735006744 putative thiostrepton binding site; other site 391735006745 L25 interface [polypeptide binding]; other site 391735006746 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 391735006747 mRNA/rRNA interface [nucleotide binding]; other site 391735006748 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 391735006749 23S rRNA interface [nucleotide binding]; other site 391735006750 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 391735006751 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 391735006752 peripheral dimer interface [polypeptide binding]; other site 391735006753 core dimer interface [polypeptide binding]; other site 391735006754 L10 interface [polypeptide binding]; other site 391735006755 L11 interface [polypeptide binding]; other site 391735006756 putative EF-Tu interaction site [polypeptide binding]; other site 391735006757 putative EF-G interaction site [polypeptide binding]; other site 391735006758 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 391735006759 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 391735006760 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 391735006761 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 391735006762 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 391735006763 RPB11 interaction site [polypeptide binding]; other site 391735006764 RPB12 interaction site [polypeptide binding]; other site 391735006765 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 391735006766 RPB3 interaction site [polypeptide binding]; other site 391735006767 RPB1 interaction site [polypeptide binding]; other site 391735006768 RPB11 interaction site [polypeptide binding]; other site 391735006769 RPB10 interaction site [polypeptide binding]; other site 391735006770 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 391735006771 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 391735006772 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 391735006773 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 391735006774 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 391735006775 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 391735006776 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 391735006777 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 391735006778 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 391735006779 DNA binding site [nucleotide binding] 391735006780 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 391735006781 16S rRNA methyltransferase B; Provisional; Region: PRK10901 391735006782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735006783 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 391735006784 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 391735006785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 391735006786 dimer interface [polypeptide binding]; other site 391735006787 phosphorylation site [posttranslational modification] 391735006788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735006789 ATP binding site [chemical binding]; other site 391735006790 Mg2+ binding site [ion binding]; other site 391735006791 G-X-G motif; other site 391735006792 Response regulator receiver domain; Region: Response_reg; pfam00072 391735006793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735006794 active site 391735006795 phosphorylation site [posttranslational modification] 391735006796 intermolecular recognition site; other site 391735006797 dimerization interface [polypeptide binding]; other site 391735006798 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391735006799 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 391735006800 Domain of unknown function (DUF718); Region: DUF718; cl01281 391735006801 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391735006802 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues...; Region: MR_like; cd03316 391735006803 active site pocket [active] 391735006804 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391735006805 active site 2 [active] 391735006806 active site 1 [active] 391735006807 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391735006808 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735006809 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391735006810 active site 2 [active] 391735006811 active site 1 [active] 391735006812 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 391735006813 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735006814 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391735006815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735006816 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391735006817 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735006818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735006819 dimer interface [polypeptide binding]; other site 391735006820 conserved gate region; other site 391735006821 putative PBP binding loops; other site 391735006822 ABC-ATPase subunit interface; other site 391735006823 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391735006824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735006825 dimer interface [polypeptide binding]; other site 391735006826 conserved gate region; other site 391735006827 putative PBP binding loops; other site 391735006828 ABC-ATPase subunit interface; other site 391735006829 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735006830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735006831 Bacterial transcriptional regulator; Region: IclR; pfam01614 391735006832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735006833 active site 391735006834 phosphorylation site [posttranslational modification] 391735006835 intermolecular recognition site; other site 391735006836 dimerization interface [polypeptide binding]; other site 391735006837 LytTr DNA-binding domain; Region: LytTR; cl04498 391735006838 Histidine kinase; Region: His_kinase; pfam06580 391735006839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 391735006840 FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 391735006841 putative active site [active] 391735006842 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 391735006843 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 391735006844 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 391735006845 Bacitracin resistance protein BacA; Region: BacA; cl00858 391735006846 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 391735006847 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 391735006848 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 391735006849 glycosyl transferase family protein; Provisional; Region: PRK08136 391735006850 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 391735006851 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391735006852 Sulfatase; Region: Sulfatase; cl10460 391735006853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735006854 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735006855 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 391735006856 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 391735006857 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 391735006858 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735006859 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 391735006860 RF-1 domain; Region: RF-1; cl02875 391735006861 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 391735006862 trimer interface [polypeptide binding]; other site 391735006863 active site 391735006864 dimer interface [polypeptide binding]; other site 391735006865 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 391735006866 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 391735006867 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 391735006868 alphaNTD homodimer interface [polypeptide binding]; other site 391735006869 alphaNTD - beta interaction site [polypeptide binding]; other site 391735006870 alphaNTD - beta' interaction site [polypeptide binding]; other site 391735006871 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 391735006872 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 391735006873 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 391735006874 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391735006875 RNA binding surface [nucleotide binding]; other site 391735006876 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 391735006877 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 391735006878 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 391735006879 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 391735006880 SecY translocase; Region: SecY; pfam00344 391735006881 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 391735006882 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 391735006883 23S rRNA binding site [nucleotide binding]; other site 391735006884 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 391735006885 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 391735006886 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 391735006887 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 391735006888 5S rRNA interface [nucleotide binding]; other site 391735006889 23S rRNA interface [nucleotide binding]; other site 391735006890 L5 interface [polypeptide binding]; other site 391735006891 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 391735006892 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 391735006893 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 391735006894 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 391735006895 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 391735006896 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 391735006897 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 391735006898 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 391735006899 KOW motif; Region: KOW; cl00354 391735006900 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 391735006901 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391735006902 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 391735006903 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391735006904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735006905 dimer interface [polypeptide binding]; other site 391735006906 conserved gate region; other site 391735006907 putative PBP binding loops; other site 391735006908 ABC-ATPase subunit interface; other site 391735006909 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 391735006910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735006911 putative PBP binding loops; other site 391735006912 ABC-ATPase subunit interface; other site 391735006913 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391735006914 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 391735006915 Walker A/P-loop; other site 391735006916 ATP binding site [chemical binding]; other site 391735006917 Q-loop/lid; other site 391735006918 ABC transporter signature motif; other site 391735006919 Walker B; other site 391735006920 D-loop; other site 391735006921 H-loop/switch region; other site 391735006922 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391735006923 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735006924 Walker A/P-loop; other site 391735006925 ATP binding site [chemical binding]; other site 391735006926 Q-loop/lid; other site 391735006927 ABC transporter signature motif; other site 391735006928 Walker B; other site 391735006929 D-loop; other site 391735006930 H-loop/switch region; other site 391735006931 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 391735006932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735006933 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 391735006934 glycerol kinase; Provisional; Region: glpK; PRK00047 391735006935 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 391735006936 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 391735006937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735006938 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 391735006939 Integrase core domain; Region: rve; cl01316 391735006940 stationary phase growth adaptation protein; Provisional; Region: PRK09717 391735006941 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391735006942 Integrase core domain; Region: rve; cl01316 391735006943 UbiA prenyltransferase family; Region: UbiA; cl00337 391735006944 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that...; Region: SGNH_arylesterase_like; cd01839 391735006945 active site 391735006946 catalytic triad [active] 391735006947 oxyanion hole [active] 391735006948 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 391735006949 putative active site; other site 391735006950 putative triphosphate binding site [ion binding]; other site 391735006951 putative metal binding residues [ion binding]; other site 391735006952 CHAD domain; Region: CHAD; cl10506 391735006953 Ferritin-like domain; Region: Ferritin; pfam00210 391735006954 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 391735006955 dimerization interface [polypeptide binding]; other site 391735006956 DPS ferroxidase diiron center [ion binding]; other site 391735006957 ion pore; other site 391735006958 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735006959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735006960 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 391735006961 dimerization interface [polypeptide binding]; other site 391735006962 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 391735006963 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 391735006964 generic binding surface II; other site 391735006965 ssDNA binding site; other site 391735006966 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735006967 ATP binding site [chemical binding]; other site 391735006968 putative Mg++ binding site [ion binding]; other site 391735006969 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391735006970 nucleotide binding region [chemical binding]; other site 391735006971 ATP-binding site [chemical binding]; other site 391735006972 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 391735006973 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 391735006974 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 391735006975 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391735006976 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 391735006977 DctM-like transporters; Region: DctM; pfam06808 391735006978 CrcB-like protein; Region: CRCB; cl09114 391735006979 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 391735006980 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 391735006981 Recombination protein O N terminal; Region: RecO_N; pfam11967 391735006982 Recombination protein O C terminal; Region: RecO_C; pfam02565 391735006983 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 391735006984 active site 391735006985 hydrophilic channel; other site 391735006986 dimerization interface [polypeptide binding]; other site 391735006987 catalytic residues [active] 391735006988 active site lid [active] 391735006989 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 391735006990 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 391735006991 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 391735006992 NAD(P) binding site [chemical binding]; other site 391735006993 homotetramer interface [polypeptide binding]; other site 391735006994 homodimer interface [polypeptide binding]; other site 391735006995 active site 391735006996 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391735006997 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391735006998 Protein export membrane protein; Region: SecD_SecF; cl14618 391735006999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735007000 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391735007001 active site residue [active] 391735007002 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 391735007003 Outer membrane efflux protein; Region: OEP; pfam02321 391735007004 Outer membrane efflux protein; Region: OEP; pfam02321 391735007005 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 391735007006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735007007 NAD(P) binding site [chemical binding]; other site 391735007008 active site 391735007009 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391735007010 CoenzymeA binding site [chemical binding]; other site 391735007011 subunit interaction site [polypeptide binding]; other site 391735007012 PHB binding site; other site 391735007013 Prostaglandin dehydrogenases; Region: PGDH; cd05288 391735007014 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 391735007015 NAD(P) binding site [chemical binding]; other site 391735007016 substrate binding site [chemical binding]; other site 391735007017 dimer interface [polypeptide binding]; other site 391735007018 Cytochrome c; Region: Cytochrom_C; cl11414 391735007019 Cytochrome c; Region: Cytochrom_C; cl11414 391735007020 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391735007021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735007022 Walker A motif; other site 391735007023 ATP binding site [chemical binding]; other site 391735007024 Walker B motif; other site 391735007025 arginine finger; other site 391735007026 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391735007027 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 391735007028 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 391735007029 Surface antigen; Region: Bac_surface_Ag; cl03097 391735007030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 391735007031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 391735007032 Family of unknown function (DUF490); Region: DUF490; pfam04357 391735007033 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 391735007034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735007035 ATP binding site [chemical binding]; other site 391735007036 putative Mg++ binding site [ion binding]; other site 391735007037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391735007038 nucleotide binding region [chemical binding]; other site 391735007039 ATP-binding site [chemical binding]; other site 391735007040 RQC domain; Region: RQC; pfam09382 391735007041 HRDC domain; Region: HRDC; cl02578 391735007042 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391735007043 FAD binding domain; Region: FAD_binding_4; pfam01565 391735007044 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735007045 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391735007046 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735007047 Walker A/P-loop; other site 391735007048 ATP binding site [chemical binding]; other site 391735007049 Q-loop/lid; other site 391735007050 ABC transporter signature motif; other site 391735007051 Walker B; other site 391735007052 D-loop; other site 391735007053 H-loop/switch region; other site 391735007054 TOBE domain; Region: TOBE_2; cl01440 391735007055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735007056 dimer interface [polypeptide binding]; other site 391735007057 conserved gate region; other site 391735007058 putative PBP binding loops; other site 391735007059 ABC-ATPase subunit interface; other site 391735007060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735007061 dimer interface [polypeptide binding]; other site 391735007062 conserved gate region; other site 391735007063 putative PBP binding loops; other site 391735007064 ABC-ATPase subunit interface; other site 391735007065 N-acetylneuraminate lyase; Region: nanA; TIGR00683 391735007066 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 391735007067 inhibitor site; inhibition site 391735007068 active site 391735007069 dimer interface [polypeptide binding]; other site 391735007070 catalytic residue [active] 391735007071 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 391735007072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735007073 Bacterial transcriptional regulator; Region: IclR; pfam01614 391735007074 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391735007075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735007076 homodimer interface [polypeptide binding]; other site 391735007077 catalytic residue [active] 391735007078 excinuclease ABC subunit B; Provisional; Region: PRK05298 391735007079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735007080 ATP binding site [chemical binding]; other site 391735007081 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391735007082 nucleotide binding region [chemical binding]; other site 391735007083 ATP-binding site [chemical binding]; other site 391735007084 Ultra-violet resistance protein B; Region: UvrB; pfam12344 391735007085 UvrB/uvrC motif; Region: UVR; pfam02151 391735007086 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735007087 Rrf2 family protein; Region: rrf2_super; TIGR00738 391735007088 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391735007089 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735007090 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735007091 catalytic residue [active] 391735007092 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 391735007093 trimerization site [polypeptide binding]; other site 391735007094 active site 391735007095 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 391735007096 co-chaperone HscB; Provisional; Region: hscB; PRK03578 391735007097 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 391735007098 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 391735007099 chaperone protein HscA; Provisional; Region: hscA; PRK05183 391735007100 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735007101 catalytic loop [active] 391735007102 iron binding site [ion binding]; other site 391735007103 Proteobacterial; Region: dnaQ_proteo; TIGR01406 391735007104 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 391735007105 active site 391735007106 substrate binding site [chemical binding]; other site 391735007107 catalytic site [active] 391735007108 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 391735007109 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 391735007110 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 391735007111 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735007112 catalytic loop [active] 391735007113 iron binding site [ion binding]; other site 391735007114 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 391735007115 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 391735007116 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_Formate-Dh-H; cd02753 391735007117 [4Fe-4S] binding site [ion binding]; other site 391735007118 molybdopterin cofactor binding site; other site 391735007119 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of...; Region: MopB_CT_Fdh-Nap-like; cd00508 391735007120 molybdopterin cofactor binding site; other site 391735007121 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 391735007122 putative dimer interface [polypeptide binding]; other site 391735007123 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 391735007124 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 391735007125 SLBB domain; Region: SLBB; pfam10531 391735007126 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 391735007127 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 391735007128 putative dimer interface [polypeptide binding]; other site 391735007129 [2Fe-2S] cluster binding site [ion binding]; other site 391735007130 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 391735007131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735007132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735007133 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 391735007134 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391735007135 dimerization interface [polypeptide binding]; other site 391735007136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735007137 NAD(P) binding site [chemical binding]; other site 391735007138 active site 391735007139 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735007140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735007141 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 391735007142 putative dimerization interface [polypeptide binding]; other site 391735007143 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 391735007144 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 391735007145 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391735007146 catalytic residue [active] 391735007147 prolyl-tRNA synthetase; Provisional; Region: PRK09194 391735007148 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 391735007149 dimer interface [polypeptide binding]; other site 391735007150 motif 1; other site 391735007151 active site 391735007152 motif 2; other site 391735007153 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 391735007154 putative deacylase active site [active] 391735007155 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391735007156 active site 391735007157 motif 3; other site 391735007158 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 391735007159 anticodon binding site; other site 391735007160 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671 391735007161 putative active site [active] 391735007162 Ap4A binding site [chemical binding]; other site 391735007163 nudix motif; other site 391735007164 putative metal binding site [ion binding]; other site 391735007165 Transposase IS200 like; Region: Y1_Tnp; cl00848 391735007166 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 391735007167 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 391735007168 active site 391735007169 dimer interface [polypeptide binding]; other site 391735007170 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 391735007171 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 391735007172 active site 391735007173 FMN binding site [chemical binding]; other site 391735007174 substrate binding site [chemical binding]; other site 391735007175 3Fe-4S cluster binding site [ion binding]; other site 391735007176 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 391735007177 domain interface; other site 391735007178 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 391735007179 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 391735007180 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 391735007181 Walker A/P-loop; other site 391735007182 ATP binding site [chemical binding]; other site 391735007183 Q-loop/lid; other site 391735007184 ABC transporter signature motif; other site 391735007185 Walker B; other site 391735007186 D-loop; other site 391735007187 H-loop/switch region; other site 391735007188 Domain of unknown function DUF140; Region: DUF140; cl00510 391735007189 mce related protein; Region: MCE; cl03606 391735007190 VacJ like lipoprotein; Region: VacJ; cl01073 391735007191 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074 391735007192 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 391735007193 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 391735007194 anti sigma factor interaction site; other site 391735007195 regulatory phosphorylation site [posttranslational modification]; other site 391735007196 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735007197 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735007198 Bacterial transcriptional regulator; Region: IclR; pfam01614 391735007199 Flavin Reductases; Region: FlaRed; cl00801 391735007200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735007201 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735007202 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 391735007203 homotrimer interaction site [polypeptide binding]; other site 391735007204 putative active site [active] 391735007205 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 391735007206 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735007207 active site 391735007208 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391735007209 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391735007210 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 391735007211 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 391735007212 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735007213 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735007214 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735007215 active site 391735007216 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 391735007217 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391735007218 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735007219 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 391735007220 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 391735007221 carboxyltransferase (CT) interaction site; other site 391735007222 biotinylation site [posttranslational modification]; other site 391735007223 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 391735007224 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391735007225 Predicted transcriptional regulator [Transcription]; Region: COG2378 391735007226 Protein of unknown function DUF262; Region: DUF262; cl14890 391735007227 Protein of unknown function DUF262; Region: DUF262; cl14890 391735007228 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 391735007229 HsdM N-terminal domain; Region: HsdM_N; pfam12161 391735007230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735007231 Virulence protein [General function prediction only]; Region: COG3943 391735007232 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 391735007233 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 391735007234 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 391735007235 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 391735007236 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 391735007237 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735007238 ATP binding site [chemical binding]; other site 391735007239 putative Mg++ binding site [ion binding]; other site 391735007240 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 391735007241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735007242 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391735007243 putative substrate translocation pore; other site 391735007244 Predicted transcriptional regulator [Transcription]; Region: COG3905 391735007245 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 391735007246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 391735007247 Leucine carboxyl methyltransferase; Region: LCM; cl01306 391735007248 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 391735007249 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735007250 salicylate synthase; Region: salicyl_syn; TIGR03494 391735007251 chorismate binding enzyme; Region: Chorismate_bind; cl10555 391735007252 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735007253 Thioesterase domain; Region: Thioesterase; pfam00975 391735007254 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 391735007255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735007256 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391735007257 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 391735007258 active site 391735007259 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391735007260 Acyl transferase domain; Region: Acyl_transf_1; cl08282 391735007261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735007262 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 391735007263 NADP binding site [chemical binding]; other site 391735007264 active site 391735007265 Condensation domain; Region: Condensation; cl09290 391735007266 Nonribosomal peptide synthase; Region: NRPS; pfam08415 391735007267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 391735007268 S-adenosylmethionine binding site [chemical binding]; other site 391735007269 peptide synthase; Provisional; Region: PRK12316 391735007270 Phosphopantetheine attachment site; Region: PP-binding; cl09936 391735007271 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 391735007272 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735007273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 391735007274 Phosphopantetheine attachment site; Region: PP-binding; cl09936 391735007275 Condensation domain; Region: Condensation; cl09290 391735007276 Nonribosomal peptide synthase; Region: NRPS; pfam08415 391735007277 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 391735007278 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735007279 peptide synthase; Provisional; Region: PRK12316 391735007280 Phosphopantetheine attachment site; Region: PP-binding; cl09936 391735007281 Condensation domain; Region: Condensation; cl09290 391735007282 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 391735007283 Nonribosomal peptide synthase; Region: NRPS; pfam08415 391735007284 Phosphopantetheine attachment site; Region: PP-binding; cl09936 391735007285 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391735007286 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 391735007287 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 391735007288 N-terminal plug; other site 391735007289 ligand-binding site [chemical binding]; other site 391735007290 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391735007291 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735007292 Walker A/P-loop; other site 391735007293 ATP binding site [chemical binding]; other site 391735007294 Q-loop/lid; other site 391735007295 ABC transporter signature motif; other site 391735007296 Walker B; other site 391735007297 D-loop; other site 391735007298 H-loop/switch region; other site 391735007299 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391735007300 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735007301 Walker A/P-loop; other site 391735007302 ATP binding site [chemical binding]; other site 391735007303 Q-loop/lid; other site 391735007304 ABC transporter signature motif; other site 391735007305 Walker B; other site 391735007306 D-loop; other site 391735007307 H-loop/switch region; other site 391735007308 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735007309 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 391735007310 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 391735007311 SAP domain; Region: SAP; cl02640 391735007312 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 391735007313 Integrase core domain; Region: rve; cl01316 391735007314 putative transposase OrfB; Reviewed; Region: PHA02517 391735007315 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 391735007316 SEC-C motif; Region: SEC-C; cl12132 391735007317 hydrogenase maturation GTPase HydF; Region: GTP_HydF; TIGR03918 391735007318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735007319 putative substrate translocation pore; other site 391735007320 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 391735007321 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391735007322 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391735007323 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735007324 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 391735007325 dimerization interface [polypeptide binding]; other site 391735007326 substrate binding pocket [chemical binding]; other site 391735007327 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735007328 classical (c) SDRs; Region: SDR_c; cd05233 391735007329 NAD(P) binding site [chemical binding]; other site 391735007330 active site 391735007331 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 391735007332 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735007333 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735007334 catalytic residue [active] 391735007335 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 391735007336 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735007337 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735007338 catalytic residue [active] 391735007339 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 391735007340 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 391735007341 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 391735007342 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 391735007343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735007344 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735007345 amidase; Provisional; Region: PRK07486 391735007346 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 391735007347 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 391735007348 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391735007349 minor groove reading motif; other site 391735007350 helix-hairpin-helix signature motif; other site 391735007351 substrate binding pocket [chemical binding]; other site 391735007352 active site 391735007353 Fic/DOC family; Region: Fic; cl00960 391735007354 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 391735007355 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391735007356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735007357 DNA-binding site [nucleotide binding]; DNA binding site 391735007358 FCD domain; Region: FCD; cl11656 391735007359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735007360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735007361 dimer interface [polypeptide binding]; other site 391735007362 conserved gate region; other site 391735007363 putative PBP binding loops; other site 391735007364 ABC-ATPase subunit interface; other site 391735007365 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391735007366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735007367 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391735007368 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735007369 Walker A/P-loop; other site 391735007370 ATP binding site [chemical binding]; other site 391735007371 Q-loop/lid; other site 391735007372 ABC transporter signature motif; other site 391735007373 Walker B; other site 391735007374 D-loop; other site 391735007375 H-loop/switch region; other site 391735007376 TOBE domain; Region: TOBE_2; cl01440 391735007377 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 391735007378 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 391735007379 homodimer interface [polypeptide binding]; other site 391735007380 substrate-cofactor binding pocket; other site 391735007381 catalytic residue [active] 391735007382 Zinc-finger domain; Region: zf-CHCC; cl01821 391735007383 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 391735007384 putative metal binding site [ion binding]; other site 391735007385 O-Antigen ligase; Region: Wzy_C; cl04850 391735007386 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a...; Region: GT1_AviGT4_like; cd03802 391735007387 putative ADP-binding pocket [chemical binding]; other site 391735007388 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 391735007389 phosphate binding site [ion binding]; other site 391735007390 Integrase core domain; Region: rve; cl01316 391735007391 Protein of unknown function DUF262; Region: DUF262; cl14890 391735007392 Integrase core domain; Region: rve; cl01316 391735007393 Protein of unknown function (DUF433); Region: DUF433; cl01030 391735007394 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 391735007395 Integrase core domain; Region: rve; cl01316 391735007396 hypothetical protein; Provisional; Region: PRK11820 391735007397 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 391735007398 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 391735007399 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735007400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735007401 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735007402 Bacterial transcriptional regulator; Region: IclR; pfam01614 391735007403 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735007404 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735007405 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735007406 active site 391735007407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735007408 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735007409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735007410 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735007411 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735007412 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735007413 active site 391735007414 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 391735007415 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 391735007416 NADP binding site [chemical binding]; other site 391735007417 dimer interface [polypeptide binding]; other site 391735007418 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391735007419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735007420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735007421 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735007422 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735007423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735007424 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735007425 dimerization interface [polypeptide binding]; other site 391735007426 Fumarase C-terminus; Region: Fumerase_C; cl00795 391735007427 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 391735007428 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 391735007429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735007430 domain; Region: Succ_DH_flav_C; pfam02910 391735007431 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR...; Region: SQR_QFR_TM; cl00881 391735007432 Iron-sulfur protein interface; other site 391735007433 proximal heme binding site [chemical binding]; other site 391735007434 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR...; Region: SQR_QFR_TM; cl00881 391735007435 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 391735007436 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391735007437 PYR/PP interface [polypeptide binding]; other site 391735007438 dimer interface [polypeptide binding]; other site 391735007439 TPP binding site [chemical binding]; other site 391735007440 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735007441 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 391735007442 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 391735007443 active site 391735007444 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735007445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735007446 Bacterial transcriptional regulator; Region: IclR; pfam01614 391735007447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735007448 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735007449 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735007450 active site 391735007451 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735007452 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735007453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391735007454 dimerization interface [polypeptide binding]; other site 391735007455 Integrase core domain; Region: rve; cl01316 391735007456 Integrase core domain; Region: rve; cl01316 391735007457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735007458 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735007459 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735007460 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 391735007461 putative transposase OrfB; Reviewed; Region: PHA02517 391735007462 Integrase core domain; Region: rve; cl01316 391735007463 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 391735007464 FtsX-like permease family; Region: FtsX; pfam02687 391735007465 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 391735007466 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391735007467 Walker A/P-loop; other site 391735007468 ATP binding site [chemical binding]; other site 391735007469 Q-loop/lid; other site 391735007470 ABC transporter signature motif; other site 391735007471 Walker B; other site 391735007472 D-loop; other site 391735007473 H-loop/switch region; other site 391735007474 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 391735007475 active site 391735007476 Integrase core domain; Region: rve; cl01316 391735007477 putative transposase OrfB; Reviewed; Region: PHA02517 391735007478 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 391735007479 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 391735007480 active site 391735007481 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 391735007482 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 391735007483 active site 391735007484 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391735007485 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 391735007486 Walker A/P-loop; other site 391735007487 ATP binding site [chemical binding]; other site 391735007488 Q-loop/lid; other site 391735007489 ABC transporter signature motif; other site 391735007490 Walker B; other site 391735007491 D-loop; other site 391735007492 H-loop/switch region; other site 391735007493 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 391735007494 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391735007495 FtsX-like permease family; Region: FtsX; pfam02687 391735007496 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391735007497 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 391735007498 putative NAD(P) binding site [chemical binding]; other site 391735007499 active site 391735007500 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391735007501 Acyl transferase domain; Region: Acyl_transf_1; cl08282 391735007502 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 391735007503 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 391735007504 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 391735007505 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 391735007506 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735007507 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391735007508 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 391735007509 NAD binding site [chemical binding]; other site 391735007510 homotetramer interface [polypeptide binding]; other site 391735007511 homodimer interface [polypeptide binding]; other site 391735007512 active site 391735007513 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735007514 Phasin protein; Region: Phasin_2; cl11491 391735007515 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 391735007516 substrate binding site [chemical binding]; other site 391735007517 Protein of unknown function (DUF521); Region: DUF521; pfam04412 391735007518 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 391735007519 substrate binding site [chemical binding]; other site 391735007520 ligand binding site [chemical binding]; other site 391735007521 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 391735007522 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 391735007523 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 391735007524 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 391735007525 active site 391735007526 substrate binding site [chemical binding]; other site 391735007527 metal binding site [ion binding]; metal-binding site 391735007528 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 391735007529 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 391735007530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391735007531 AlkA N-terminal domain; Region: AlkA_N; pfam06029 391735007532 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 391735007533 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391735007534 minor groove reading motif; other site 391735007535 helix-hairpin-helix signature motif; other site 391735007536 active site 391735007537 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 391735007538 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 391735007539 DNA binding site [nucleotide binding] 391735007540 active site 391735007541 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 391735007542 EamA-like transporter family; Region: EamA; cl01037 391735007543 EamA-like transporter family; Region: EamA; cl01037 391735007544 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 391735007545 Ligand binding site [chemical binding]; other site 391735007546 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 391735007547 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 391735007548 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 391735007549 UvrD/REP helicase; Region: UvrD-helicase; cl14126 391735007550 putative recombination protein RecB; Provisional; Region: PRK13909 391735007551 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 391735007552 oligomerisation interface [polypeptide binding]; other site 391735007553 mobile loop; other site 391735007554 roof hairpin; other site 391735007555 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 391735007556 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 391735007557 ring oligomerisation interface [polypeptide binding]; other site 391735007558 ATP/Mg binding site [chemical binding]; other site 391735007559 stacking interactions; other site 391735007560 hinge regions; other site 391735007561 Protein of unknown function (DUF805); Region: DUF805; cl01224 391735007562 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 391735007563 active site 391735007564 intersubunit interface [polypeptide binding]; other site 391735007565 catalytic residue [active] 391735007566 Dehydratase family; Region: ILVD_EDD; cl00340 391735007567 6-phosphogluconate dehydratase; Region: edd; TIGR01196 391735007568 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 391735007569 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391735007570 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 391735007571 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735007572 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 391735007573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391735007574 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 391735007575 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 391735007576 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine'...; Region: Peptidase_C39_likeA; cd02417 391735007577 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 391735007578 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 391735007579 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735007580 Walker A/P-loop; other site 391735007581 ATP binding site [chemical binding]; other site 391735007582 Q-loop/lid; other site 391735007583 ABC transporter signature motif; other site 391735007584 Walker B; other site 391735007585 D-loop; other site 391735007586 H-loop/switch region; other site 391735007587 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 391735007588 nucleophilic elbow; other site 391735007589 catalytic triad; other site 391735007590 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 391735007591 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 391735007592 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 391735007593 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; cl12108 391735007594 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 391735007595 Tetramer interface [polypeptide binding]; other site 391735007596 Active site [active] 391735007597 FMN-binding site [chemical binding]; other site 391735007598 thiolase; Provisional; Region: PRK06158 391735007599 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 391735007600 active site 391735007601 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 391735007602 DUF35 OB-fold domain; Region: DUF35; pfam01796 391735007603 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 391735007604 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735007605 substrate binding site [chemical binding]; other site 391735007606 oxyanion hole (OAH) forming residues; other site 391735007607 trimer interface [polypeptide binding]; other site 391735007608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735007609 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735007610 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 391735007611 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 391735007612 ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to...; Region: ABCC_ATM1_transporter; cd03253 391735007613 Walker A/P-loop; other site 391735007614 ATP binding site [chemical binding]; other site 391735007615 Q-loop/lid; other site 391735007616 ABC transporter signature motif; other site 391735007617 Walker B; other site 391735007618 D-loop; other site 391735007619 H-loop/switch region; other site 391735007620 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735007621 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 391735007622 ANTAR domain; Region: ANTAR; pfam03861 391735007623 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391735007624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735007625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735007626 dimer interface [polypeptide binding]; other site 391735007627 conserved gate region; other site 391735007628 putative PBP binding loops; other site 391735007629 ABC-ATPase subunit interface; other site 391735007630 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 391735007631 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 391735007632 Walker A/P-loop; other site 391735007633 ATP binding site [chemical binding]; other site 391735007634 Q-loop/lid; other site 391735007635 ABC transporter signature motif; other site 391735007636 Walker B; other site 391735007637 D-loop; other site 391735007638 H-loop/switch region; other site 391735007639 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 391735007640 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735007641 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 391735007642 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 391735007643 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391735007644 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 391735007645 [2Fe-2S] cluster binding site [ion binding]; other site 391735007646 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 391735007647 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 391735007648 [4Fe-4S] binding site [ion binding]; other site 391735007649 molybdopterin cofactor binding site; other site 391735007650 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 391735007651 molybdopterin cofactor binding site; other site 391735007652 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 391735007653 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 391735007654 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 391735007655 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 391735007656 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 391735007657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735007658 dimer interface [polypeptide binding]; other site 391735007659 conserved gate region; other site 391735007660 putative PBP binding loops; other site 391735007661 ABC-ATPase subunit interface; other site 391735007662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735007663 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391735007664 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 391735007665 Walker A/P-loop; other site 391735007666 ATP binding site [chemical binding]; other site 391735007667 Q-loop/lid; other site 391735007668 ABC transporter signature motif; other site 391735007669 Walker B; other site 391735007670 D-loop; other site 391735007671 H-loop/switch region; other site 391735007672 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391735007673 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735007674 substrate binding pocket [chemical binding]; other site 391735007675 membrane-bound complex binding site; other site 391735007676 hinge residues; other site 391735007677 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391735007678 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 391735007679 putative active site [active] 391735007680 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 391735007681 putative metal binding site [ion binding]; other site 391735007682 transcription termination factor Rho; Provisional; Region: rho; PRK09376 391735007683 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 391735007684 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 391735007685 RNA binding site [nucleotide binding]; other site 391735007686 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 391735007687 multimer interface [polypeptide binding]; other site 391735007688 Walker A motif; other site 391735007689 ATP binding site [chemical binding]; other site 391735007690 Walker B motif; other site 391735007691 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 391735007692 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 391735007693 active site 391735007694 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 391735007695 Coenzyme A transferase; Region: CoA_trans; cl00773 391735007696 Coenzyme A transferase; Region: CoA_trans; cl00773 391735007697 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735007698 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735007699 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 391735007700 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391735007701 UvrD/REP helicase; Region: UvrD-helicase; cl14126 391735007702 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391735007703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391735007704 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 391735007705 nucleoside/Zn binding site; other site 391735007706 dimer interface [polypeptide binding]; other site 391735007707 catalytic motif [active] 391735007708 haloalkane dehalogenase; Provisional; Region: PRK00870 391735007709 ribonuclease G; Provisional; Region: PRK11712 391735007710 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 391735007711 homodimer interface [polypeptide binding]; other site 391735007712 oligonucleotide binding site [chemical binding]; other site 391735007713 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 391735007714 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 391735007715 Domain of unknown function DUF143; Region: DUF143; cl00519 391735007716 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 391735007717 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391735007718 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 391735007719 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 391735007720 Divergent AAA domain; Region: AAA_4; pfam04326 391735007721 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 391735007722 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 391735007723 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 391735007724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391735007725 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391735007726 Integrase core domain; Region: rve; cl01316 391735007727 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 391735007728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 391735007729 dimer interface [polypeptide binding]; other site 391735007730 phosphorylation site [posttranslational modification] 391735007731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735007732 ATP binding site [chemical binding]; other site 391735007733 G-X-G motif; other site 391735007734 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391735007735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735007736 active site 391735007737 phosphorylation site [posttranslational modification] 391735007738 intermolecular recognition site; other site 391735007739 dimerization interface [polypeptide binding]; other site 391735007740 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 391735007741 DNA binding site [nucleotide binding] 391735007742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 391735007743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 391735007744 Peptidase family M48; Region: Peptidase_M48; cl12018 391735007745 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 391735007746 23S rRNA interface [nucleotide binding]; other site 391735007747 L3 interface [polypeptide binding]; other site 391735007748 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 391735007749 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 391735007750 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 391735007751 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 391735007752 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 391735007753 Peptidase family M23; Region: Peptidase_M23; pfam01551 391735007754 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 391735007755 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 391735007756 active site 391735007757 HIGH motif; other site 391735007758 dimer interface [polypeptide binding]; other site 391735007759 KMSKS motif; other site 391735007760 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 391735007761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735007762 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391735007763 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735007764 dimerization interface [polypeptide binding]; other site 391735007765 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 391735007766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735007767 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735007768 Septum formation initiator; Region: DivIC; cl11433 391735007769 enolase; Provisional; Region: eno; PRK00077 391735007770 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 391735007771 dimer interface [polypeptide binding]; other site 391735007772 metal binding site [ion binding]; metal-binding site 391735007773 substrate binding pocket [chemical binding]; other site 391735007774 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 391735007775 NeuB family; Region: NeuB; cl00496 391735007776 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 391735007777 CTP synthetase; Validated; Region: pyrG; PRK05380 391735007778 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 391735007779 Catalytic site [active] 391735007780 Active site [active] 391735007781 UTP binding site [chemical binding]; other site 391735007782 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 391735007783 active site 391735007784 putative oxyanion hole; other site 391735007785 catalytic triad [active] 391735007786 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 391735007787 Flavoprotein; Region: Flavoprotein; cl08021 391735007788 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 391735007789 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 391735007790 trimer interface [polypeptide binding]; other site 391735007791 active site 391735007792 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 391735007793 Cupin superfamily protein; Region: Cupin_4; pfam08007 391735007794 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 391735007795 catalytic residues [active] 391735007796 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 391735007797 putative ligand binding site [chemical binding]; other site 391735007798 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome...; Region: Xcc1710_like; cd05560 391735007799 alanine aminotransferase; Provisional; Region: PTZ00377 391735007800 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391735007801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735007802 homodimer interface [polypeptide binding]; other site 391735007803 catalytic residue [active] 391735007804 homoserine dehydrogenase; Provisional; Region: PRK06349 391735007805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735007806 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 391735007807 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 391735007808 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 391735007809 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560 391735007810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735007811 catalytic residue [active] 391735007812 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 391735007813 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 391735007814 dimer interface [polypeptide binding]; other site 391735007815 putative functional site; other site 391735007816 putative MPT binding site; other site 391735007817 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 391735007818 MoaE interaction surface [polypeptide binding]; other site 391735007819 MoeB interaction surface [polypeptide binding]; other site 391735007820 thiocarboxylated glycine; other site 391735007821 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735007822 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 391735007823 putative ligand binding site [chemical binding]; other site 391735007824 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391735007825 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391735007826 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391735007827 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 391735007828 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 391735007829 iron-sulfur cluster [ion binding]; other site 391735007830 [2Fe-2S] cluster binding site [ion binding]; other site 391735007831 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 391735007832 putative alpha subunit interface [polypeptide binding]; other site 391735007833 putative active site [active] 391735007834 putative substrate binding site [chemical binding]; other site 391735007835 Fe binding site [ion binding]; other site 391735007836 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735007837 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 391735007838 putative ligand binding site [chemical binding]; other site 391735007839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735007840 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735007841 NAD(P) binding site [chemical binding]; other site 391735007842 active site 391735007843 Putative cyclase; Region: Cyclase; cl00814 391735007844 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 391735007845 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 391735007846 DUF35 OB-fold domain; Region: DUF35; pfam01796 391735007847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735007848 NAD(P) binding site [chemical binding]; other site 391735007849 active site 391735007850 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 391735007851 thiolase; Provisional; Region: PRK06158 391735007852 active site 391735007853 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 391735007854 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735007855 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 391735007856 inter-subunit interface; other site 391735007857 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 391735007858 iron-sulfur cluster [ion binding]; other site 391735007859 [2Fe-2S] cluster binding site [ion binding]; other site 391735007860 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 391735007861 putative alpha subunit interface [polypeptide binding]; other site 391735007862 putative active site [active] 391735007863 putative substrate binding site [chemical binding]; other site 391735007864 Fe binding site [ion binding]; other site 391735007865 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391735007866 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 391735007867 FMN-binding pocket [chemical binding]; other site 391735007868 flavin binding motif; other site 391735007869 phosphate binding motif [ion binding]; other site 391735007870 beta-alpha-beta structure motif; other site 391735007871 NAD binding pocket [chemical binding]; other site 391735007872 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735007873 catalytic loop [active] 391735007874 iron binding site [ion binding]; other site 391735007875 acetyl-CoA synthetase; Provisional; Region: PRK00174 391735007876 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_9; cd06318 391735007877 putative ligand binding site [chemical binding]; other site 391735007878 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 391735007879 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 391735007880 putative NAD(P) binding site [chemical binding]; other site 391735007881 catalytic Zn binding site [ion binding]; other site 391735007882 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 391735007883 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 391735007884 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 391735007885 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 391735007886 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 391735007887 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735007888 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735007889 Walker A/P-loop; other site 391735007890 ATP binding site [chemical binding]; other site 391735007891 Q-loop/lid; other site 391735007892 ABC transporter signature motif; other site 391735007893 Walker B; other site 391735007894 D-loop; other site 391735007895 H-loop/switch region; other site 391735007896 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735007897 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735007898 TM-ABC transporter signature motif; other site 391735007899 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 391735007900 intersubunit interface [polypeptide binding]; other site 391735007901 active site 391735007902 catalytic residue [active] 391735007903 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 391735007904 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735007905 NAD(P) binding site [chemical binding]; other site 391735007906 catalytic residues [active] 391735007907 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391735007908 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 391735007909 Integrase core domain; Region: rve; cl01316 391735007910 LOTUS is an uncharacterized small globular domain found in Limkain b1, Oskar and Tudor-containing proteins 5 and 7; Region: LOTUS; cl14879 391735007911 periplasmic folding chaperone; Provisional; Region: PRK10788 391735007912 PPIC-type PPIASE domain; Region: Rotamase; cl08278 391735007913 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 391735007914 IHF dimer interface [polypeptide binding]; other site 391735007915 IHF - DNA interface [nucleotide binding]; other site 391735007916 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 391735007917 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 391735007918 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 391735007919 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 391735007920 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 391735007921 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 391735007922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735007923 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735007924 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; cl01823 391735007925 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 391735007926 dimer interface [polypeptide binding]; other site 391735007927 active site 391735007928 metal binding site [ion binding]; metal-binding site 391735007929 glutathione binding site [chemical binding]; other site 391735007930 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 391735007931 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 391735007932 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391735007933 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 391735007934 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 391735007935 inhibitor site; inhibition site 391735007936 active site 391735007937 dimer interface [polypeptide binding]; other site 391735007938 catalytic residue [active] 391735007939 Cytochrome c [Energy production and conversion]; Region: COG3258 391735007940 Cytochrome c; Region: Cytochrom_C; cl11414 391735007941 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391735007942 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved...; Region: MR_like_2; cd03327 391735007943 putative active site pocket [active] 391735007944 putative metal binding site [ion binding]; other site 391735007945 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 391735007946 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 391735007947 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 391735007948 putative ligand binding site [chemical binding]; other site 391735007949 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735007950 TM-ABC transporter signature motif; other site 391735007951 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735007952 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735007953 Walker A/P-loop; other site 391735007954 ATP binding site [chemical binding]; other site 391735007955 Q-loop/lid; other site 391735007956 ABC transporter signature motif; other site 391735007957 Walker B; other site 391735007958 D-loop; other site 391735007959 H-loop/switch region; other site 391735007960 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735007961 Uncharacterized conserved protein [Function unknown]; Region: COG3391 391735007962 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 391735007963 acyl-CoA synthetase; Validated; Region: PRK08162 391735007964 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391735007965 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735007966 DNA-binding site [nucleotide binding]; DNA binding site 391735007967 FCD domain; Region: FCD; cl11656 391735007968 enoyl-CoA hydratase; Validated; Region: PRK08139 391735007969 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735007970 substrate binding site [chemical binding]; other site 391735007971 oxyanion hole (OAH) forming residues; other site 391735007972 trimer interface [polypeptide binding]; other site 391735007973 OsmC-like protein; Region: OsmC; cl00767 391735007974 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735007975 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735007976 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735007977 Walker A/P-loop; other site 391735007978 ATP binding site [chemical binding]; other site 391735007979 Q-loop/lid; other site 391735007980 ABC transporter signature motif; other site 391735007981 Walker B; other site 391735007982 D-loop; other site 391735007983 H-loop/switch region; other site 391735007984 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 391735007985 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735007986 putative ligand binding site [chemical binding]; other site 391735007987 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735007988 TM-ABC transporter signature motif; other site 391735007989 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735007990 TM-ABC transporter signature motif; other site 391735007991 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735007992 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735007993 Walker A/P-loop; other site 391735007994 ATP binding site [chemical binding]; other site 391735007995 Q-loop/lid; other site 391735007996 ABC transporter signature motif; other site 391735007997 Walker B; other site 391735007998 D-loop; other site 391735007999 H-loop/switch region; other site 391735008000 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 391735008001 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735008002 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391735008003 Beta-lactamase; Region: Beta-lactamase; cl01009 391735008004 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 391735008005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735008006 CoA-ligase; Region: Ligase_CoA; pfam00549 391735008007 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 391735008008 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735008009 CoA-ligase; Region: Ligase_CoA; pfam00549 391735008010 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 391735008011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735008012 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 391735008013 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 391735008014 NlpC/P60 family; Region: NLPC_P60; cl11438 391735008015 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 391735008016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391735008017 non-specific DNA binding site [nucleotide binding]; other site 391735008018 salt bridge; other site 391735008019 sequence-specific DNA binding site [nucleotide binding]; other site 391735008020 Cupin domain; Region: Cupin_2; cl09118 391735008021 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 391735008022 Sodium:solute symporter family; Region: SSF; cl00456 391735008023 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391735008024 active site 391735008025 metal binding site [ion binding]; metal-binding site 391735008026 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 391735008027 homotrimer interaction site [polypeptide binding]; other site 391735008028 putative active site [active] 391735008029 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 391735008030 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 391735008031 inhibitor site; inhibition site 391735008032 active site 391735008033 dimer interface [polypeptide binding]; other site 391735008034 catalytic residue [active] 391735008035 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391735008036 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735008037 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 391735008038 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735008039 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 391735008040 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 391735008041 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 391735008042 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735008043 substrate binding site [chemical binding]; other site 391735008044 oxyanion hole (OAH) forming residues; other site 391735008045 trimer interface [polypeptide binding]; other site 391735008046 EamA-like transporter family; Region: EamA; cl01037 391735008047 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 391735008048 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 391735008049 G1 box; other site 391735008050 putative GEF interaction site [polypeptide binding]; other site 391735008051 GTP/Mg2+ binding site [chemical binding]; other site 391735008052 Switch I region; other site 391735008053 G2 box; other site 391735008054 G3 box; other site 391735008055 Switch II region; other site 391735008056 G4 box; other site 391735008057 G5 box; other site 391735008058 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 391735008059 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 391735008060 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 391735008061 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 391735008062 RNA binding site [nucleotide binding]; other site 391735008063 active site 391735008064 Ribosome-binding factor A; Region: RBFA; cl00542 391735008065 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 391735008066 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 391735008067 translation initiation factor IF-2; Region: IF-2; TIGR00487 391735008068 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 391735008069 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 391735008070 G1 box; other site 391735008071 putative GEF interaction site [polypeptide binding]; other site 391735008072 GTP/Mg2+ binding site [chemical binding]; other site 391735008073 Switch I region; other site 391735008074 G2 box; other site 391735008075 G3 box; other site 391735008076 Switch II region; other site 391735008077 G4 box; other site 391735008078 G5 box; other site 391735008079 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 391735008080 Translation-initiation factor 2; Region: IF-2; pfam11987 391735008081 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 391735008082 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 391735008083 NusA N-terminal domain; Region: NusA_N; pfam08529 391735008084 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 391735008085 RNA binding site [nucleotide binding]; other site 391735008086 homodimer interface [polypeptide binding]; other site 391735008087 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 391735008088 G-X-X-G motif; other site 391735008089 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 391735008090 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 391735008091 ribosome maturation protein RimP; Reviewed; Region: PRK00092 391735008092 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 391735008093 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 391735008094 Sm1 motif; other site 391735008095 malonyl-CoA synthase; Validated; Region: PRK07514 391735008096 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735008097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735008098 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008099 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 391735008100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735008101 DNA-binding site [nucleotide binding]; DNA binding site 391735008102 FCD domain; Region: FCD; cl11656 391735008103 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 391735008104 putative homotetramer interface [polypeptide binding]; other site 391735008105 putative homodimer interface [polypeptide binding]; other site 391735008106 putative metal binding site [ion binding]; other site 391735008107 putative homodimer-homodimer interface [polypeptide binding]; other site 391735008108 putative allosteric switch controlling residues; other site 391735008109 High-affinity nickel-transport protein; Region: NicO; cl00964 391735008110 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 391735008111 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 391735008112 GTP/Mg2+ binding site [chemical binding]; other site 391735008113 G4 box; other site 391735008114 G5 box; other site 391735008115 G1 box; other site 391735008116 Switch I region; other site 391735008117 G2 box; other site 391735008118 G3 box; other site 391735008119 Switch II region; other site 391735008120 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 391735008121 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 391735008122 glutaminase active site [active] 391735008123 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 391735008124 dimer interface [polypeptide binding]; other site 391735008125 active site 391735008126 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 391735008127 dimer interface [polypeptide binding]; other site 391735008128 active site 391735008129 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735008130 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735008131 enoyl-CoA hydratase; Provisional; Region: PRK06210 391735008132 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735008133 substrate binding site [chemical binding]; other site 391735008134 oxyanion hole (OAH) forming residues; other site 391735008135 trimer interface [polypeptide binding]; other site 391735008136 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735008137 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735008138 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735008139 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 391735008140 putative transposase OrfB; Reviewed; Region: PHA02517 391735008141 Integrase core domain; Region: rve; cl01316 391735008142 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391735008143 nucleotide binding region [chemical binding]; other site 391735008144 ATP-binding site [chemical binding]; other site 391735008145 integrase; Provisional; Region: PRK09692 391735008146 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 391735008147 active site 391735008148 Int/Topo IB signature motif; other site 391735008149 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391735008150 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 391735008151 FMN-binding pocket [chemical binding]; other site 391735008152 flavin binding motif; other site 391735008153 phosphate binding motif [ion binding]; other site 391735008154 beta-alpha-beta structure motif; other site 391735008155 NAD binding pocket [chemical binding]; other site 391735008156 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735008157 catalytic loop [active] 391735008158 iron binding site [ion binding]; other site 391735008159 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 391735008160 inter-subunit interface; other site 391735008161 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391735008162 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 391735008163 active site 1 [active] 391735008164 dimer interface [polypeptide binding]; other site 391735008165 hexamer interface [polypeptide binding]; other site 391735008166 active site 2 [active] 391735008167 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 391735008168 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 391735008169 active site 391735008170 catalytic residues [active] 391735008171 metal binding site [ion binding]; metal-binding site 391735008172 DmpG-like communication domain; Region: DmpG_comm; pfam07836 391735008173 acetaldehyde dehydrogenase; Validated; Region: PRK08300 391735008174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735008175 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 391735008176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735008177 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008178 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391735008179 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391735008180 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 391735008181 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735008182 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735008183 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 391735008184 NAD binding site [chemical binding]; other site 391735008185 catalytic residues [active] 391735008186 Domain of unknown function (DUF336); Region: DUF336; cl01249 391735008187 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 391735008188 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 391735008189 tetramer interface [polypeptide binding]; other site 391735008190 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 391735008191 tetramer interface [polypeptide binding]; other site 391735008192 active site 391735008193 Fe binding site [ion binding]; other site 391735008194 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 391735008195 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735008196 catalytic loop [active] 391735008197 iron binding site [ion binding]; other site 391735008198 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P); Region: phenol_2-monooxygenase_like; cd06211 391735008199 FAD binding pocket [chemical binding]; other site 391735008200 FAD binding motif [chemical binding]; other site 391735008201 phosphate binding motif [ion binding]; other site 391735008202 beta-alpha-beta structure motif; other site 391735008203 NAD binding pocket [chemical binding]; other site 391735008204 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 391735008205 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 391735008206 dimerization interface [polypeptide binding]; other site 391735008207 putative path to active site cavity [active] 391735008208 diiron center [ion binding]; other site 391735008209 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 391735008210 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 391735008211 dimerization interface [polypeptide binding]; other site 391735008212 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 391735008213 Activator of aromatic catabolism; Region: XylR_N; pfam06505 391735008214 V4R domain; Region: V4R; cl08369 391735008215 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 391735008216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735008217 Walker A motif; other site 391735008218 ATP binding site [chemical binding]; other site 391735008219 Walker B motif; other site 391735008220 arginine finger; other site 391735008221 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 391735008222 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391735008223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735008224 DNA-binding site [nucleotide binding]; DNA binding site 391735008225 FCD domain; Region: FCD; cl11656 391735008226 ATP-dependent helicase HepA; Validated; Region: PRK04914 391735008227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735008228 ATP binding site [chemical binding]; other site 391735008229 putative Mg++ binding site [ion binding]; other site 391735008230 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 391735008231 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 391735008232 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 391735008233 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 391735008234 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 391735008235 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 391735008236 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 391735008237 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 391735008238 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 391735008239 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 391735008240 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 391735008241 4Fe-4S binding domain; Region: Fer4; cl02805 391735008242 NADH dehydrogenase; Region: NADHdh; cl00469 391735008243 NADH dehydrogenase subunit G; Validated; Region: PRK09129 391735008244 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735008245 catalytic loop [active] 391735008246 iron binding site [ion binding]; other site 391735008247 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 391735008248 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions...; Region: MopB_NDH-1_NuoG2; cd02772 391735008249 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 391735008250 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 391735008251 SLBB domain; Region: SLBB; pfam10531 391735008252 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 391735008253 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 391735008254 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 391735008255 putative dimer interface [polypeptide binding]; other site 391735008256 [2Fe-2S] cluster binding site [ion binding]; other site 391735008257 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 391735008258 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 391735008259 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 391735008260 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 391735008261 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 391735008262 substrate binding site [chemical binding]; other site 391735008263 dimer interface [polypeptide binding]; other site 391735008264 catalytic triad [active] 391735008265 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 391735008266 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 391735008267 NAD(P) binding site [chemical binding]; other site 391735008268 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 391735008269 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 391735008270 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 391735008271 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 391735008272 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 391735008273 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 391735008274 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 391735008275 putative nucleic acid binding region [nucleotide binding]; other site 391735008276 G-X-X-G motif; other site 391735008277 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 391735008278 RNA binding site [nucleotide binding]; other site 391735008279 domain interface; other site 391735008280 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 391735008281 16S/18S rRNA binding site [nucleotide binding]; other site 391735008282 S13e-L30e interaction site [polypeptide binding]; other site 391735008283 25S rRNA binding site [nucleotide binding]; other site 391735008284 aspartate aminotransferase; Provisional; Region: PRK08361 391735008285 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391735008286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735008287 homodimer interface [polypeptide binding]; other site 391735008288 catalytic residue [active] 391735008289 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 391735008290 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 391735008291 catalytic motif [active] 391735008292 Zn binding site [ion binding]; other site 391735008293 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 391735008294 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 391735008295 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 391735008296 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 391735008297 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 391735008298 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 391735008299 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 391735008300 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 391735008301 Type II transport protein GspH; Region: GspH; pfam12019 391735008302 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735008303 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 391735008304 substrate binding pocket [chemical binding]; other site 391735008305 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 391735008306 active site 391735008307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 391735008308 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 391735008309 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 391735008310 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 391735008311 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 391735008312 DNA binding residues [nucleotide binding] 391735008313 dimer interface [polypeptide binding]; other site 391735008314 putative metal binding site [ion binding]; other site 391735008315 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 391735008316 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735008317 active site 391735008318 hypothetical protein; Provisional; Region: PRK06194 391735008319 classical (c) SDRs; Region: SDR_c; cd05233 391735008320 NAD(P) binding site [chemical binding]; other site 391735008321 active site 391735008322 aminodeoxychorismate synthase; Provisional; Region: PRK07508 391735008323 chorismate binding enzyme; Region: Chorismate_bind; cl10555 391735008324 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 391735008325 substrate-cofactor binding pocket; other site 391735008326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735008327 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 391735008328 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 391735008329 Predicted amidohydrolase [General function prediction only]; Region: COG0388 391735008330 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 391735008331 putative active site [active] 391735008332 catalytic triad [active] 391735008333 putative dimer interface [polypeptide binding]; other site 391735008334 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 391735008335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735008336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008337 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 391735008338 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 391735008339 ParB-like nuclease domain; Region: ParBc; cl02129 391735008340 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 391735008341 catalytic residues [active] 391735008342 catalytic nucleophile [active] 391735008343 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735008344 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 391735008345 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735008346 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735008347 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735008348 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735008349 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735008350 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 391735008351 RelB antitoxin; Region: RelB; cl01171 391735008352 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 391735008353 PemK-like protein; Region: PemK; cl00995 391735008354 RelB antitoxin; Region: RelB; cl01171 391735008355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 391735008356 Protein of unknown function (DUF497); Region: DUF497; cl01108 391735008357 enolase; Provisional; Region: eno; PRK00077 391735008358 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 391735008359 dimer interface [polypeptide binding]; other site 391735008360 metal binding site [ion binding]; metal-binding site 391735008361 substrate binding pocket [chemical binding]; other site 391735008362 Phosphotransferase enzyme family; Region: APH; pfam01636 391735008363 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 391735008364 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 391735008365 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735008366 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 391735008367 active site 391735008368 FMN binding site [chemical binding]; other site 391735008369 substrate binding site [chemical binding]; other site 391735008370 homotetramer interface [polypeptide binding]; other site 391735008371 catalytic residue [active] 391735008372 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735008373 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735008374 Walker A/P-loop; other site 391735008375 ATP binding site [chemical binding]; other site 391735008376 Q-loop/lid; other site 391735008377 ABC transporter signature motif; other site 391735008378 Walker B; other site 391735008379 D-loop; other site 391735008380 H-loop/switch region; other site 391735008381 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735008382 TM-ABC transporter signature motif; other site 391735008383 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735008384 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735008385 Walker A/P-loop; other site 391735008386 ATP binding site [chemical binding]; other site 391735008387 Q-loop/lid; other site 391735008388 ABC transporter signature motif; other site 391735008389 Walker B; other site 391735008390 D-loop; other site 391735008391 H-loop/switch region; other site 391735008392 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735008393 TM-ABC transporter signature motif; other site 391735008394 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735008395 classical (c) SDRs; Region: SDR_c; cd05233 391735008396 NAD(P) binding site [chemical binding]; other site 391735008397 active site 391735008398 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735008399 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 391735008400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735008401 active site 391735008402 phosphorylation site [posttranslational modification] 391735008403 intermolecular recognition site; other site 391735008404 dimerization interface [polypeptide binding]; other site 391735008405 LytTr DNA-binding domain; Region: LytTR; cl04498 391735008406 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 391735008407 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 391735008408 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391735008409 Protein of unknown function (DUF497); Region: DUF497; cl01108 391735008410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 391735008411 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 391735008412 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735008413 Walker A/P-loop; other site 391735008414 ATP binding site [chemical binding]; other site 391735008415 Q-loop/lid; other site 391735008416 ABC transporter signature motif; other site 391735008417 Walker B; other site 391735008418 D-loop; other site 391735008419 H-loop/switch region; other site 391735008420 TOBE domain; Region: TOBE_2; cl01440 391735008421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735008422 dimer interface [polypeptide binding]; other site 391735008423 ABC-ATPase subunit interface; other site 391735008424 putative PBP binding loops; other site 391735008425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008426 Acyl transferase domain; Region: Acyl_transf_1; cl08282 391735008427 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 391735008428 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 391735008429 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913 391735008430 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735008431 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735008432 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 391735008433 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 391735008434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735008435 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008436 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391735008437 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735008438 DNA-binding site [nucleotide binding]; DNA binding site 391735008439 FCD domain; Region: FCD; cl11656 391735008440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735008441 benzoate transport; Region: 2A0115; TIGR00895 391735008442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735008443 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735008444 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735008445 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391735008446 dimerization interface [polypeptide binding]; other site 391735008447 aspartate aminotransferase; Provisional; Region: PRK08361 391735008448 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391735008449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735008450 homodimer interface [polypeptide binding]; other site 391735008451 catalytic residue [active] 391735008452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735008453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735008455 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008456 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 391735008457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735008458 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735008459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391735008460 dimerization interface [polypeptide binding]; other site 391735008461 5-oxoprolinase; Region: PLN02666 391735008462 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391735008463 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 391735008464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735008465 putative substrate translocation pore; other site 391735008466 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 391735008467 galactonate dehydratase; Provisional; Region: PRK14017 391735008468 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues...; Region: MR_like; cd03316 391735008469 active site pocket [active] 391735008470 choline dehydrogenase; Validated; Region: PRK02106 391735008471 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391735008472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008473 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391735008474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735008475 dimer interface [polypeptide binding]; other site 391735008476 conserved gate region; other site 391735008477 putative PBP binding loops; other site 391735008478 ABC-ATPase subunit interface; other site 391735008479 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391735008480 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 391735008481 Walker A/P-loop; other site 391735008482 ATP binding site [chemical binding]; other site 391735008483 Q-loop/lid; other site 391735008484 ABC transporter signature motif; other site 391735008485 Walker B; other site 391735008486 D-loop; other site 391735008487 H-loop/switch region; other site 391735008488 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 391735008489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735008490 dimer interface [polypeptide binding]; other site 391735008491 conserved gate region; other site 391735008492 putative PBP binding loops; other site 391735008493 ABC-ATPase subunit interface; other site 391735008494 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 391735008495 Isochorismatase family; Region: Isochorismatase; pfam00857 391735008496 catalytic triad [active] 391735008497 conserved cis-peptide bond; other site 391735008498 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391735008499 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391735008500 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 391735008501 active site 391735008502 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391735008503 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391735008504 conserved cys residue [active] 391735008505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391735008506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735008507 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008508 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 391735008509 classical (c) SDRs; Region: SDR_c; cd05233 391735008510 NAD(P) binding site [chemical binding]; other site 391735008511 active site 391735008512 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735008513 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 391735008514 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391735008515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735008516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735008517 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 391735008518 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391735008519 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 391735008520 FMN-binding pocket [chemical binding]; other site 391735008521 flavin binding motif; other site 391735008522 phosphate binding motif [ion binding]; other site 391735008523 beta-alpha-beta structure motif; other site 391735008524 NAD binding pocket [chemical binding]; other site 391735008525 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735008526 catalytic loop [active] 391735008527 iron binding site [ion binding]; other site 391735008528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735008529 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008530 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391735008531 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3,4-...; Region: Rieske_RO_Alpha_PhDO_like; cd03479 391735008532 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391735008533 hydrophobic ligand binding site; other site 391735008534 cation-binding hemerythrin HHE family protein; Provisional; Region: PRK01917 391735008535 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735008536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735008537 Bacterial transcriptional regulator; Region: IclR; pfam01614 391735008538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735008539 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008540 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 391735008541 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735008542 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 391735008543 DNA binding residues [nucleotide binding] 391735008544 dimerization interface [polypeptide binding]; other site 391735008545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735008546 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 391735008547 NAD(P) binding site [chemical binding]; other site 391735008548 active site 391735008549 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 391735008550 DUF35 OB-fold domain; Region: DUF35; pfam01796 391735008551 thiolase; Provisional; Region: PRK06158 391735008552 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 391735008553 active site 391735008554 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 391735008555 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735008556 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735008557 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735008558 active site 391735008559 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 391735008560 active site 391735008561 catalytic site [active] 391735008562 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 391735008563 active site 391735008564 catalytic site [active] 391735008565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735008566 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008567 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 391735008568 homotrimer interaction site [polypeptide binding]; other site 391735008569 putative active site [active] 391735008570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008571 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391735008572 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735008573 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735008574 catalytic residue [active] 391735008575 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391735008576 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391735008577 ligand binding site [chemical binding]; other site 391735008578 flexible hinge region; other site 391735008579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735008580 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 391735008581 active site 391735008582 putative DNA-binding cleft [nucleotide binding]; other site 391735008583 dimer interface [polypeptide binding]; other site 391735008584 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 391735008585 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 391735008586 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 391735008587 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 391735008588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391735008589 metal binding site [ion binding]; metal-binding site 391735008590 active site 391735008591 I-site; other site 391735008592 Guanylate kinase; Region: Guanylate_kin; cl12021 391735008593 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 391735008594 Protein of unknown function (DUF1045); Region: DUF1045; pfam06299 391735008595 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 391735008596 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 391735008597 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; cl01456 391735008598 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 391735008599 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 391735008600 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735008601 Walker A/P-loop; other site 391735008602 ATP binding site [chemical binding]; other site 391735008603 Q-loop/lid; other site 391735008604 ABC transporter signature motif; other site 391735008605 Walker B; other site 391735008606 D-loop; other site 391735008607 H-loop/switch region; other site 391735008608 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735008609 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 391735008610 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735008611 Walker A/P-loop; other site 391735008612 ATP binding site [chemical binding]; other site 391735008613 Q-loop/lid; other site 391735008614 ABC transporter signature motif; other site 391735008615 Walker B; other site 391735008616 D-loop; other site 391735008617 H-loop/switch region; other site 391735008618 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 391735008619 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735008620 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 391735008621 active site 391735008622 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 391735008623 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 391735008624 Walker A/P-loop; other site 391735008625 ATP binding site [chemical binding]; other site 391735008626 Q-loop/lid; other site 391735008627 ABC transporter signature motif; other site 391735008628 Walker B; other site 391735008629 D-loop; other site 391735008630 H-loop/switch region; other site 391735008631 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008632 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 391735008633 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 391735008634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735008635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735008636 DNA-binding site [nucleotide binding]; DNA binding site 391735008637 FCD domain; Region: FCD; cl11656 391735008638 Cupin domain; Region: Cupin_2; cl09118 391735008639 NIPSNAP; Region: NIPSNAP; pfam07978 391735008640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735008641 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391735008642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735008643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735008645 NAD(P) binding site [chemical binding]; other site 391735008646 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391735008647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008648 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391735008649 PhoD-like phosphatase; Region: PhoD; pfam09423 391735008650 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 391735008651 putative active site [active] 391735008652 putative metal binding site [ion binding]; other site 391735008653 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 391735008654 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 391735008655 active site 391735008656 catalytic site [active] 391735008657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735008658 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008659 Cation efflux family; Region: Cation_efflux; cl00316 391735008660 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391735008661 DNA binding residues [nucleotide binding] 391735008662 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 391735008663 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 391735008664 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 391735008665 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 391735008666 peptide synthase; Validated; Region: PRK05691 391735008667 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735008668 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735008669 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391735008670 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735008671 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735008672 catalytic residue [active] 391735008673 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 391735008674 trimerization site [polypeptide binding]; other site 391735008675 active site 391735008676 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735008677 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735008678 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735008679 GatB domain; Region: GatB_Yqey; cl11497 391735008680 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 391735008681 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735008682 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735008683 Walker A/P-loop; other site 391735008684 ATP binding site [chemical binding]; other site 391735008685 Q-loop/lid; other site 391735008686 ABC transporter signature motif; other site 391735008687 Walker B; other site 391735008688 D-loop; other site 391735008689 H-loop/switch region; other site 391735008690 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735008691 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735008692 Walker A/P-loop; other site 391735008693 ATP binding site [chemical binding]; other site 391735008694 Q-loop/lid; other site 391735008695 ABC transporter signature motif; other site 391735008696 Walker B; other site 391735008697 D-loop; other site 391735008698 H-loop/switch region; other site 391735008699 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735008700 TM-ABC transporter signature motif; other site 391735008701 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735008702 TM-ABC transporter signature motif; other site 391735008703 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 391735008704 dimer interface [polypeptide binding]; other site 391735008705 substrate binding site [chemical binding]; other site 391735008706 metal binding sites [ion binding]; metal-binding site 391735008707 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 391735008708 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 391735008709 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735008710 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 391735008711 NAD(P) binding site [chemical binding]; other site 391735008712 catalytic residues [active] 391735008713 catalytic residues [active] 391735008714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735008715 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735008716 NAD(P) binding site [chemical binding]; other site 391735008717 active site 391735008718 HsdM N-terminal domain; Region: HsdM_N; pfam12161 391735008719 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 391735008720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735008721 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 391735008722 Virulence protein [General function prediction only]; Region: COG3943 391735008723 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 391735008724 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 391735008725 active site 391735008726 NTP binding site [chemical binding]; other site 391735008727 metal binding triad [ion binding]; metal-binding site 391735008728 antibiotic binding site [chemical binding]; other site 391735008729 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 391735008730 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 391735008731 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 391735008732 Virulence protein [General function prediction only]; Region: COG3943 391735008733 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 391735008734 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 391735008735 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735008736 ATP binding site [chemical binding]; other site 391735008737 putative Mg++ binding site [ion binding]; other site 391735008738 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 391735008739 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391735008740 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 391735008741 Walker A/P-loop; other site 391735008742 ATP binding site [chemical binding]; other site 391735008743 Q-loop/lid; other site 391735008744 ABC transporter signature motif; other site 391735008745 Walker B; other site 391735008746 D-loop; other site 391735008747 H-loop/switch region; other site 391735008748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735008749 dimer interface [polypeptide binding]; other site 391735008750 conserved gate region; other site 391735008751 putative PBP binding loops; other site 391735008752 ABC-ATPase subunit interface; other site 391735008753 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735008754 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391735008755 substrate binding pocket [chemical binding]; other site 391735008756 membrane-bound complex binding site; other site 391735008757 hinge residues; other site 391735008758 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 391735008759 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 391735008760 putative binding surface; other site 391735008761 active site 391735008762 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 391735008763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735008764 ATP binding site [chemical binding]; other site 391735008765 Mg2+ binding site [ion binding]; other site 391735008766 G-X-G motif; other site 391735008767 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 391735008768 Response regulator receiver domain; Region: Response_reg; pfam00072 391735008769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735008770 active site 391735008771 phosphorylation site [posttranslational modification] 391735008772 intermolecular recognition site; other site 391735008773 dimerization interface [polypeptide binding]; other site 391735008774 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391735008775 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 391735008776 Response regulator receiver domain; Region: Response_reg; pfam00072 391735008777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735008778 active site 391735008779 phosphorylation site [posttranslational modification] 391735008780 intermolecular recognition site; other site 391735008781 dimerization interface [polypeptide binding]; other site 391735008782 Response regulator receiver domain; Region: Response_reg; pfam00072 391735008783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735008784 active site 391735008785 phosphorylation site [posttranslational modification] 391735008786 intermolecular recognition site; other site 391735008787 dimerization interface [polypeptide binding]; other site 391735008788 Rubredoxin [Energy production and conversion]; Region: COG1773 391735008789 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 391735008790 iron binding site [ion binding]; other site 391735008791 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 391735008792 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 391735008793 dimer interface [polypeptide binding]; other site 391735008794 substrate binding site [chemical binding]; other site 391735008795 ATP binding site [chemical binding]; other site 391735008796 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 391735008797 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 391735008798 inhibitor-cofactor binding pocket; inhibition site 391735008799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735008800 catalytic residue [active] 391735008801 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 391735008802 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 391735008803 purine monophosphate binding site [chemical binding]; other site 391735008804 dimer interface [polypeptide binding]; other site 391735008805 putative catalytic residues [active] 391735008806 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 391735008807 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 391735008808 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 391735008809 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 391735008810 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 391735008811 FMN binding site [chemical binding]; other site 391735008812 active site 391735008813 catalytic residues [active] 391735008814 substrate binding site [chemical binding]; other site 391735008815 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 391735008816 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 391735008817 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 391735008818 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 391735008819 active site 391735008820 FMN binding site [chemical binding]; other site 391735008821 substrate binding site [chemical binding]; other site 391735008822 3Fe-4S cluster binding site [ion binding]; other site 391735008823 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 391735008824 domain_subunit interface; other site 391735008825 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 391735008826 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 391735008827 active site 391735008828 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 391735008829 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391735008830 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 391735008831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391735008832 non-specific DNA binding site [nucleotide binding]; other site 391735008833 salt bridge; other site 391735008834 sequence-specific DNA binding site [nucleotide binding]; other site 391735008835 Cupin domain; Region: Cupin_2; cl09118 391735008836 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391735008837 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735008838 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 391735008839 dimerization interface [polypeptide binding]; other site 391735008840 substrate binding pocket [chemical binding]; other site 391735008841 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735008842 Walker A/P-loop; other site 391735008843 ATP binding site [chemical binding]; other site 391735008844 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 391735008845 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to L-threo-; Region: Glm_e; cl02025 391735008846 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 391735008847 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735008848 Walker A/P-loop; other site 391735008849 ATP binding site [chemical binding]; other site 391735008850 Q-loop/lid; other site 391735008851 ABC transporter signature motif; other site 391735008852 Walker B; other site 391735008853 D-loop; other site 391735008854 H-loop/switch region; other site 391735008855 ABC-2 type transporter; Region: ABC2_membrane; cl11417 391735008856 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 391735008857 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 391735008858 putative hydrophobic ligand binding site [chemical binding]; other site 391735008859 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735008860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735008861 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 391735008862 putative dimerization interface [polypeptide binding]; other site 391735008863 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 391735008864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735008865 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008866 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735008867 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391735008868 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 391735008869 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 391735008870 dimer interface [polypeptide binding]; other site 391735008871 putative anticodon binding site; other site 391735008872 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 391735008873 motif 1; other site 391735008874 active site 391735008875 motif 2; other site 391735008876 motif 3; other site 391735008877 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 391735008878 Bacterial sugar transferase; Region: Bac_transf; cl00939 391735008879 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 391735008880 Fumarase C-terminus; Region: Fumerase_C; cl00795 391735008881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735008882 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008883 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 391735008884 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 391735008885 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 391735008886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735008887 Bacterial transcriptional regulator; Region: IclR; pfam01614 391735008888 Flavin Reductases; Region: FlaRed; cl00801 391735008889 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 391735008890 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 391735008891 active site 391735008892 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 391735008893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735008894 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cd06181 391735008895 Domain of unknown function (DUF336); Region: DUF336; cl01249 391735008896 Hemin uptake protein hemP; Region: hemP; cl10043 391735008897 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 391735008898 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 391735008899 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 391735008900 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 391735008901 Gram-negative bacterial tonB protein; Region: TonB; cl10048 391735008902 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 391735008903 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 391735008904 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 391735008905 Walker A/P-loop; other site 391735008906 ATP binding site [chemical binding]; other site 391735008907 Q-loop/lid; other site 391735008908 ABC transporter signature motif; other site 391735008909 Walker B; other site 391735008910 D-loop; other site 391735008911 H-loop/switch region; other site 391735008912 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 391735008913 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 391735008914 ABC-ATPase subunit interface; other site 391735008915 dimer interface [polypeptide binding]; other site 391735008916 putative PBP binding regions; other site 391735008917 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 391735008918 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 391735008919 intersubunit interface [polypeptide binding]; other site 391735008920 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 391735008921 ChuX-like family; Region: DUF1008; cl01509 391735008922 ChuX-like family; Region: DUF1008; cl01509 391735008923 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 391735008924 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 391735008925 N-terminal plug; other site 391735008926 ligand-binding site [chemical binding]; other site 391735008927 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 391735008928 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 391735008929 active site 391735008930 substrate binding site [chemical binding]; other site 391735008931 FMN binding site [chemical binding]; other site 391735008932 putative catalytic residues [active] 391735008933 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 391735008934 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 391735008935 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 391735008936 N-terminal plug; other site 391735008937 ligand-binding site [chemical binding]; other site 391735008938 SWIB/MDM2 domain; Region: SWIB; cl02489 391735008939 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 391735008940 tetramer interface [polypeptide binding]; other site 391735008941 active site 391735008942 Mg2+/Mn2+ binding site [ion binding]; other site 391735008943 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 391735008944 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 391735008945 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 391735008946 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 391735008947 active site 391735008948 dimer interface [polypeptide binding]; other site 391735008949 motif 1; other site 391735008950 motif 2; other site 391735008951 motif 3; other site 391735008952 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 391735008953 anticodon binding site; other site 391735008954 translation initiation factor IF-3; Region: infC; TIGR00168 391735008955 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 391735008956 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 391735008957 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 391735008958 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 391735008959 23S rRNA binding site [nucleotide binding]; other site 391735008960 L21 binding site [polypeptide binding]; other site 391735008961 L13 binding site [polypeptide binding]; other site 391735008962 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 391735008963 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 391735008964 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 391735008965 dimer interface [polypeptide binding]; other site 391735008966 motif 1; other site 391735008967 active site 391735008968 motif 2; other site 391735008969 motif 3; other site 391735008970 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 391735008971 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 391735008972 putative tRNA-binding site [nucleotide binding]; other site 391735008973 B3/4 domain; Region: B3_4; cl11458 391735008974 tRNA synthetase B5 domain; Region: B5; cl08394 391735008975 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 391735008976 dimer interface [polypeptide binding]; other site 391735008977 motif 1; other site 391735008978 motif 3; other site 391735008979 motif 2; other site 391735008980 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 391735008981 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 391735008982 IHF - DNA interface [nucleotide binding]; other site 391735008983 IHF dimer interface [polypeptide binding]; other site 391735008984 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 391735008985 DNA binding residues [nucleotide binding] 391735008986 Sensors of blue-light using FAD; Region: BLUF; pfam04940 391735008987 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 391735008988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735008989 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735008990 dimerization interface [polypeptide binding]; other site 391735008991 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391735008992 non-specific DNA binding site [nucleotide binding]; other site 391735008993 salt bridge; other site 391735008994 sequence-specific DNA binding site [nucleotide binding]; other site 391735008995 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 391735008996 HipA-like N-terminal domain; Region: HipA_N; pfam07805 391735008997 HipA-like C-terminal domain; Region: HipA_C; pfam07804 391735008998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391735008999 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391735009000 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 391735009001 Integrase core domain; Region: rve; cl01316 391735009002 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 391735009003 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 391735009004 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 391735009005 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 391735009006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 391735009007 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 391735009008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 391735009009 motif II; other site 391735009010 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 391735009011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 391735009012 S-adenosylmethionine binding site [chemical binding]; other site 391735009013 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391735009014 ligand binding site [chemical binding]; other site 391735009015 DNA gyrase subunit A; Validated; Region: PRK05560 391735009016 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 391735009017 CAP-like domain; other site 391735009018 Active site [active] 391735009019 primary dimer interface [polypeptide binding]; other site 391735009020 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391735009021 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391735009022 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391735009023 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391735009024 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391735009025 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391735009026 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735009027 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735009028 catalytic residue [active] 391735009029 Chorismate mutase type II; Region: CM_2; cl00693 391735009030 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 391735009031 Prephenate dehydratase; Region: PDT; pfam00800 391735009032 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 391735009033 putative L-Phe binding site [chemical binding]; other site 391735009034 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 391735009035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735009036 bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidine monophosphate kinase; Provisional; Region: PRK11860 391735009037 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 391735009038 hinge; other site 391735009039 active site 391735009040 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 391735009041 CMP-binding site; other site 391735009042 The sites determining sugar specificity; other site 391735009043 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 391735009044 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 391735009045 RNA binding site [nucleotide binding]; other site 391735009046 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 391735009047 RNA binding site [nucleotide binding]; other site 391735009048 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 391735009049 RNA binding site [nucleotide binding]; other site 391735009050 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 391735009051 RNA binding site [nucleotide binding]; other site 391735009052 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 391735009053 RNA binding site [nucleotide binding]; other site 391735009054 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 391735009055 RNA binding site [nucleotide binding]; other site 391735009056 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 391735009057 IHF dimer interface [polypeptide binding]; other site 391735009058 IHF - DNA interface [nucleotide binding]; other site 391735009059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735009060 HsdM N-terminal domain; Region: HsdM_N; pfam12161 391735009061 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 391735009062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735009063 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 391735009064 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 391735009065 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 391735009066 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 391735009067 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 391735009068 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 391735009069 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 391735009070 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 391735009071 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 391735009072 Integrase core domain; Region: rve; cl01316 391735009073 Transposase domain (DUF772); Region: DUF772; cl12084 391735009074 hypothetical protein; Provisional; Region: PRK07481 391735009075 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 391735009076 inhibitor-cofactor binding pocket; inhibition site 391735009077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735009078 catalytic residue [active] 391735009079 putative amidase; Provisional; Region: PRK06169 391735009080 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 391735009081 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391735009082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735009083 NAD(P) binding site [chemical binding]; other site 391735009084 active site 391735009085 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 391735009086 cytosine deaminase; Provisional; Region: PRK05985 391735009087 active site 391735009088 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 391735009089 homotrimer interaction site [polypeptide binding]; other site 391735009090 putative active site [active] 391735009091 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391735009092 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 391735009093 FMN-binding pocket [chemical binding]; other site 391735009094 flavin binding motif; other site 391735009095 phosphate binding motif [ion binding]; other site 391735009096 beta-alpha-beta structure motif; other site 391735009097 NAD binding pocket [chemical binding]; other site 391735009098 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735009099 catalytic loop [active] 391735009100 iron binding site [ion binding]; other site 391735009101 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 391735009102 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735009103 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391735009104 FAD binding domain; Region: FAD_binding_4; pfam01565 391735009105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735009106 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391735009107 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 391735009108 Walker A/P-loop; other site 391735009109 ATP binding site [chemical binding]; other site 391735009110 Q-loop/lid; other site 391735009111 ABC transporter signature motif; other site 391735009112 Walker B; other site 391735009113 D-loop; other site 391735009114 H-loop/switch region; other site 391735009115 Creatinine amidohydrolase; Region: Creatininase; cl00618 391735009116 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 391735009117 Arylesterase; Region: Arylesterase; pfam01731 391735009118 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 391735009119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735009120 Response regulator receiver domain; Region: Response_reg; pfam00072 391735009121 active site 391735009122 phosphorylation site [posttranslational modification] 391735009123 intermolecular recognition site; other site 391735009124 dimerization interface [polypeptide binding]; other site 391735009125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735009126 Walker A motif; other site 391735009127 ATP binding site [chemical binding]; other site 391735009128 Walker B motif; other site 391735009129 arginine finger; other site 391735009130 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 391735009131 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 391735009132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 391735009133 dimer interface [polypeptide binding]; other site 391735009134 phosphorylation site [posttranslational modification] 391735009135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735009136 ATP binding site [chemical binding]; other site 391735009137 Mg2+ binding site [ion binding]; other site 391735009138 G-X-G motif; other site 391735009139 glutamine synthetase; Provisional; Region: glnA; PRK09469 391735009140 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391735009141 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391735009142 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 391735009143 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 391735009144 putative MPT binding site; other site 391735009145 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 391735009146 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 391735009147 Uncharacterized conserved protein [Function unknown]; Region: COG3391 391735009148 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 391735009149 adenylosuccinate synthetase; Provisional; Region: PRK01117 391735009150 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 391735009151 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 391735009152 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 391735009153 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 391735009154 dimer interface [polypeptide binding]; other site 391735009155 motif 1; other site 391735009156 active site 391735009157 motif 2; other site 391735009158 motif 3; other site 391735009159 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 391735009160 D-xylulose kinase; Region: XylB; TIGR01312 391735009161 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 391735009162 Cupin domain; Region: Cupin_2; cl09118 391735009163 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 391735009164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391735009165 sorbitol dehydrogenase; Provisional; Region: PRK07067 391735009166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735009167 NAD(P) binding site [chemical binding]; other site 391735009168 active site 391735009169 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 391735009170 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 391735009171 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 391735009172 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391735009173 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 391735009174 Walker A/P-loop; other site 391735009175 ATP binding site [chemical binding]; other site 391735009176 Q-loop/lid; other site 391735009177 ABC transporter signature motif; other site 391735009178 Walker B; other site 391735009179 D-loop; other site 391735009180 H-loop/switch region; other site 391735009181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735009182 dimer interface [polypeptide binding]; other site 391735009183 conserved gate region; other site 391735009184 putative PBP binding loops; other site 391735009185 ABC-ATPase subunit interface; other site 391735009186 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 391735009187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735009188 conserved gate region; other site 391735009189 dimer interface [polypeptide binding]; other site 391735009190 putative PBP binding loops; other site 391735009191 ABC-ATPase subunit interface; other site 391735009192 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391735009193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735009194 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 391735009195 dimerization interface [polypeptide binding]; other site 391735009196 active site 391735009197 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 391735009198 folate binding site [chemical binding]; other site 391735009199 NADP+ binding site [chemical binding]; other site 391735009200 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 391735009201 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 391735009202 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 391735009203 SET domain; Region: SET; cl02566 391735009204 DNA topoisomerase III; Validated; Region: PRK08173 391735009205 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 391735009206 active site 391735009207 putative interdomain interaction site [polypeptide binding]; other site 391735009208 putative metal-binding site [ion binding]; other site 391735009209 putative nucleotide binding site [chemical binding]; other site 391735009210 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 391735009211 domain I; other site 391735009212 DNA binding groove [nucleotide binding] 391735009213 phosphate binding site [ion binding]; other site 391735009214 domain II; other site 391735009215 domain III; other site 391735009216 nucleotide binding site [chemical binding]; other site 391735009217 catalytic site [active] 391735009218 domain IV; other site 391735009219 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 391735009220 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 391735009221 phosphate binding site [ion binding]; other site 391735009222 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 391735009223 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 391735009224 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735009225 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 391735009226 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 391735009227 Walker A/P-loop; other site 391735009228 ATP binding site [chemical binding]; other site 391735009229 Q-loop/lid; other site 391735009230 ABC transporter signature motif; other site 391735009231 Walker B; other site 391735009232 D-loop; other site 391735009233 H-loop/switch region; other site 391735009234 LolC/E family; Region: lolCE; TIGR02212 391735009235 FtsX-like permease family; Region: FtsX; pfam02687 391735009236 Sulfatase; Region: Sulfatase; cl10460 391735009237 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 391735009238 DHH family; Region: DHH; pfam01368 391735009239 DHHA1 domain; Region: DHHA1; pfam02272 391735009240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735009241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735009242 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735009243 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735009244 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 391735009245 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735009246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735009247 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 391735009248 putative effector binding pocket; other site 391735009249 putative dimerization interface [polypeptide binding]; other site 391735009250 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391735009251 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735009252 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 391735009253 dimerization interface [polypeptide binding]; other site 391735009254 substrate binding pocket [chemical binding]; other site 391735009255 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391735009256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735009257 Walker A/P-loop; other site 391735009258 ATP binding site [chemical binding]; other site 391735009259 Q-loop/lid; other site 391735009260 ABC transporter signature motif; other site 391735009261 Walker B; other site 391735009262 D-loop; other site 391735009263 H-loop/switch region; other site 391735009264 TOBE domain; Region: TOBE_2; cl01440 391735009265 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391735009266 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735009267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735009268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735009269 dimer interface [polypeptide binding]; other site 391735009270 conserved gate region; other site 391735009271 putative PBP binding loops; other site 391735009272 ABC-ATPase subunit interface; other site 391735009273 Amidinotransferase; Region: Amidinotransf; cl12043 391735009274 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 391735009275 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 391735009276 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391735009277 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391735009278 aminotransferase; Provisional; Region: PRK06105 391735009279 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 391735009280 inhibitor-cofactor binding pocket; inhibition site 391735009281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735009282 catalytic residue [active] 391735009283 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735009284 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391735009285 tetramerization interface [polypeptide binding]; other site 391735009286 NAD(P) binding site [chemical binding]; other site 391735009287 catalytic residues [active] 391735009288 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 391735009289 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735009290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735009291 dimer interface [polypeptide binding]; other site 391735009292 conserved gate region; other site 391735009293 putative PBP binding loops; other site 391735009294 ABC-ATPase subunit interface; other site 391735009295 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 391735009296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735009297 dimer interface [polypeptide binding]; other site 391735009298 conserved gate region; other site 391735009299 ABC-ATPase subunit interface; other site 391735009300 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735009301 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 391735009302 Walker A/P-loop; other site 391735009303 ATP binding site [chemical binding]; other site 391735009304 Q-loop/lid; other site 391735009305 ABC transporter signature motif; other site 391735009306 Walker B; other site 391735009307 D-loop; other site 391735009308 H-loop/switch region; other site 391735009309 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 391735009310 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735009311 Walker A/P-loop; other site 391735009312 ATP binding site [chemical binding]; other site 391735009313 Q-loop/lid; other site 391735009314 ABC transporter signature motif; other site 391735009315 Walker B; other site 391735009316 D-loop; other site 391735009317 H-loop/switch region; other site 391735009318 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735009319 NIMA-related protein kinase; Provisional; Region: PTZ00266 391735009320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 391735009321 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 391735009322 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 391735009323 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735009324 Walker A/P-loop; other site 391735009325 ATP binding site [chemical binding]; other site 391735009326 Q-loop/lid; other site 391735009327 ABC transporter signature motif; other site 391735009328 Walker B; other site 391735009329 D-loop; other site 391735009330 H-loop/switch region; other site 391735009331 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 391735009332 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735009333 Walker A/P-loop; other site 391735009334 ATP binding site [chemical binding]; other site 391735009335 Q-loop/lid; other site 391735009336 ABC transporter signature motif; other site 391735009337 Walker B; other site 391735009338 D-loop; other site 391735009339 H-loop/switch region; other site 391735009340 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735009341 TM-ABC transporter signature motif; other site 391735009342 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735009343 TM-ABC transporter signature motif; other site 391735009344 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735009345 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 391735009346 putative ligand binding site [chemical binding]; other site 391735009347 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391735009348 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 391735009349 Fumarase C-terminus; Region: Fumerase_C; cl00795 391735009350 fumarate hydratase; Reviewed; Region: fumC; PRK00485 391735009351 Class II fumarases; Region: Fumarase_classII; cd01362 391735009352 active site 391735009353 tetramer interface [polypeptide binding]; other site 391735009354 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 391735009355 acetyl-CoA synthetase; Provisional; Region: PRK00174 391735009356 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 391735009357 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735009358 Cytochrome c; Region: Cytochrom_C; cl11414 391735009359 Dehydratase family; Region: ILVD_EDD; cl00340 391735009360 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 391735009361 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 391735009362 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 391735009363 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 391735009364 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 391735009365 choline dehydrogenase; Validated; Region: PRK02106 391735009366 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735009367 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391735009368 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 391735009369 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 391735009370 NAD binding site [chemical binding]; other site 391735009371 catalytic Zn binding site [ion binding]; other site 391735009372 structural Zn binding site [ion binding]; other site 391735009373 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735009374 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 391735009375 PAS fold; Region: PAS_3; pfam08447 391735009376 hypothetical protein; Provisional; Region: PRK13560 391735009377 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 391735009378 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391735009379 metal binding site [ion binding]; metal-binding site 391735009380 active site 391735009381 I-site; other site 391735009382 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391735009383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 391735009384 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 391735009385 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 391735009386 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 391735009387 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 391735009388 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391735009389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 391735009390 FeS/SAM binding site; other site 391735009391 elongation factor P; Validated; Region: PRK00529 391735009392 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 391735009393 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 391735009394 RNA binding site [nucleotide binding]; other site 391735009395 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 391735009396 RNA binding site [nucleotide binding]; other site 391735009397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735009398 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735009399 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 391735009400 active site 391735009401 catalytic residues [active] 391735009402 metal binding site [ion binding]; metal-binding site 391735009403 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735009404 GTPase Era; Reviewed; Region: era; PRK00089 391735009405 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 391735009406 G1 box; other site 391735009407 GTP/Mg2+ binding site [chemical binding]; other site 391735009408 Switch I region; other site 391735009409 G2 box; other site 391735009410 Switch II region; other site 391735009411 G3 box; other site 391735009412 G4 box; other site 391735009413 G5 box; other site 391735009414 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 391735009415 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 391735009416 dimerization interface [polypeptide binding]; other site 391735009417 active site 391735009418 metal binding site [ion binding]; metal-binding site 391735009419 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 391735009420 signal peptidase I; Provisional; Region: PRK10861 391735009421 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 391735009422 Catalytic site [active] 391735009423 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 391735009424 GTP-binding protein LepA; Provisional; Region: PRK05433 391735009425 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 391735009426 G1 box; other site 391735009427 putative GEF interaction site [polypeptide binding]; other site 391735009428 GTP/Mg2+ binding site [chemical binding]; other site 391735009429 Switch I region; other site 391735009430 G2 box; other site 391735009431 G3 box; other site 391735009432 Switch II region; other site 391735009433 G4 box; other site 391735009434 G5 box; other site 391735009435 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 391735009436 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 391735009437 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 391735009438 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 391735009439 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 391735009440 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 391735009441 protein binding site [polypeptide binding]; other site 391735009442 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 391735009443 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 391735009444 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 391735009445 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391735009446 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 391735009447 DNA binding residues [nucleotide binding] 391735009448 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 391735009449 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391735009450 dimer interface [polypeptide binding]; other site 391735009451 active site 391735009452 Phosphopantetheine attachment site; Region: PP-binding; cl09936 391735009453 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 391735009454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735009455 NAD(P) binding site [chemical binding]; other site 391735009456 active site 391735009457 Acyl transferase domain; Region: Acyl_transf_1; cl08282 391735009458 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391735009459 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 391735009460 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 391735009461 dimer interface [polypeptide binding]; other site 391735009462 active site 391735009463 CoA binding pocket [chemical binding]; other site 391735009464 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 391735009465 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 391735009466 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391735009467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735009468 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735009469 AMP-binding enzyme; Region: AMP-binding; pfam00501 391735009470 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 391735009471 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735009472 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735009473 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735009474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735009475 active site 391735009476 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 391735009477 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735009478 active site 391735009479 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 391735009480 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735009481 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 391735009482 substrate binding pocket [chemical binding]; other site 391735009483 dimerization interface [polypeptide binding]; other site 391735009484 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 391735009485 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 391735009486 active site 391735009487 dimer interface [polypeptide binding]; other site 391735009488 Predicted methyltransferases [General function prediction only]; Region: COG0313 391735009489 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 391735009490 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 391735009491 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 391735009492 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735009493 catalytic residue [active] 391735009494 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391735009495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735009496 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391735009497 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 391735009498 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391735009499 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391735009500 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735009501 Active site [active] 391735009502 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391735009503 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 391735009504 DNA interaction; other site 391735009505 Metal-binding active site; metal-binding site 391735009506 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 391735009507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735009508 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735009509 TM-ABC transporter signature motif; other site 391735009510 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735009511 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735009512 Walker A/P-loop; other site 391735009513 ATP binding site [chemical binding]; other site 391735009514 Q-loop/lid; other site 391735009515 ABC transporter signature motif; other site 391735009516 Walker B; other site 391735009517 D-loop; other site 391735009518 H-loop/switch region; other site 391735009519 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735009520 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391735009521 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 391735009522 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 391735009523 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 391735009524 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 391735009525 active site 391735009526 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 391735009527 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 391735009528 active site residue [active] 391735009529 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 391735009530 active site residue [active] 391735009531 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391735009532 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 391735009533 [2Fe-2S] cluster binding site [ion binding]; other site 391735009534 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 391735009535 alpha subunit interface [polypeptide binding]; other site 391735009536 active site 391735009537 substrate binding site [chemical binding]; other site 391735009538 Fe binding site [ion binding]; other site 391735009539 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 391735009540 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 391735009541 substrate binding pocket [chemical binding]; other site 391735009542 chain length determination region; other site 391735009543 substrate-Mg2+ binding site; other site 391735009544 catalytic residues [active] 391735009545 aspartate-rich region 1; other site 391735009546 active site lid residues [active] 391735009547 aspartate-rich region 2; other site 391735009548 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 391735009549 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 391735009550 TPP-binding site; other site 391735009551 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391735009552 PYR/PP interface [polypeptide binding]; other site 391735009553 dimer interface [polypeptide binding]; other site 391735009554 TPP binding site [chemical binding]; other site 391735009555 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391735009556 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 391735009557 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 391735009558 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 391735009559 Sulfate transporter family; Region: Sulfate_transp; cl00967 391735009560 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 391735009561 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391735009562 metal binding site [ion binding]; metal-binding site 391735009563 active site 391735009564 I-site; other site 391735009565 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 391735009566 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 391735009567 P-loop; other site 391735009568 ADP binding residues [chemical binding]; other site 391735009569 Switch I; other site 391735009570 Switch II; other site 391735009571 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735009572 TM-ABC transporter signature motif; other site 391735009573 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391735009574 ligand binding site [chemical binding]; other site 391735009575 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735009576 TM-ABC transporter signature motif; other site 391735009577 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 391735009578 Strictosidine synthase; Region: Str_synth; pfam03088 391735009579 Strictosidine synthase; Region: Str_synth; pfam03088 391735009580 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735009581 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735009582 Walker A/P-loop; other site 391735009583 ATP binding site [chemical binding]; other site 391735009584 Q-loop/lid; other site 391735009585 ABC transporter signature motif; other site 391735009586 Walker B; other site 391735009587 D-loop; other site 391735009588 H-loop/switch region; other site 391735009589 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735009590 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 391735009591 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 391735009592 NAD binding site [chemical binding]; other site 391735009593 catalytic Zn binding site [ion binding]; other site 391735009594 substrate binding site [chemical binding]; other site 391735009595 structural Zn binding site [ion binding]; other site 391735009596 OPT oligopeptide transporter protein; Region: OPT; cl14607 391735009597 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391735009598 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735009599 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735009600 catalytic residue [active] 391735009601 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 391735009602 active site pocket [active] 391735009603 oxyanion hole [active] 391735009604 catalytic triad [active] 391735009605 active site nucleophile [active] 391735009606 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 391735009607 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 391735009608 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 391735009609 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 391735009610 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391735009611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735009612 active site 391735009613 phosphorylation site [posttranslational modification] 391735009614 intermolecular recognition site; other site 391735009615 dimerization interface [polypeptide binding]; other site 391735009616 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 391735009617 DNA binding residues [nucleotide binding] 391735009618 dimerization interface [polypeptide binding]; other site 391735009619 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735009620 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 391735009621 tetrameric interface [polypeptide binding]; other site 391735009622 NAD binding site [chemical binding]; other site 391735009623 catalytic residues [active] 391735009624 substrate binding site [chemical binding]; other site 391735009625 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391735009626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735009627 dimer interface [polypeptide binding]; other site 391735009628 conserved gate region; other site 391735009629 putative PBP binding loops; other site 391735009630 ABC-ATPase subunit interface; other site 391735009631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735009632 dimer interface [polypeptide binding]; other site 391735009633 conserved gate region; other site 391735009634 putative PBP binding loops; other site 391735009635 ABC-ATPase subunit interface; other site 391735009636 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391735009637 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735009638 Walker A/P-loop; other site 391735009639 ATP binding site [chemical binding]; other site 391735009640 Q-loop/lid; other site 391735009641 ABC transporter signature motif; other site 391735009642 Walker B; other site 391735009643 D-loop; other site 391735009644 H-loop/switch region; other site 391735009645 TOBE domain; Region: TOBE_2; cl01440 391735009646 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735009647 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735009648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735009649 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 391735009650 putative substrate binding pocket [chemical binding]; other site 391735009651 dimerization interface [polypeptide binding]; other site 391735009652 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 391735009653 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 391735009654 Cysteine-rich domain; Region: CCG; pfam02754 391735009655 Cysteine-rich domain; Region: CCG; pfam02754 391735009656 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 391735009657 FAD binding domain; Region: FAD_binding_4; pfam01565 391735009658 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 391735009659 Nitrogen regulatory protein P-II; Region: P-II; cl00412 391735009660 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 391735009661 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 391735009662 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735009663 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391735009664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735009665 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 391735009666 dimerization interface [polypeptide binding]; other site 391735009667 substrate binding pocket [chemical binding]; other site 391735009668 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 391735009669 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735009670 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735009671 active site 391735009672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735009673 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735009674 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 391735009675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735009676 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 391735009677 homotrimer interaction site [polypeptide binding]; other site 391735009678 putative active site [active] 391735009679 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391735009680 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 391735009681 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735009682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735009683 dimer interface [polypeptide binding]; other site 391735009684 conserved gate region; other site 391735009685 putative PBP binding loops; other site 391735009686 ABC-ATPase subunit interface; other site 391735009687 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391735009688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735009689 dimer interface [polypeptide binding]; other site 391735009690 conserved gate region; other site 391735009691 putative PBP binding loops; other site 391735009692 ABC-ATPase subunit interface; other site 391735009693 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735009694 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735009695 Walker A/P-loop; other site 391735009696 ATP binding site [chemical binding]; other site 391735009697 Q-loop/lid; other site 391735009698 ABC transporter signature motif; other site 391735009699 Walker B; other site 391735009700 D-loop; other site 391735009701 H-loop/switch region; other site 391735009702 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735009703 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391735009704 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735009705 Walker A/P-loop; other site 391735009706 ATP binding site [chemical binding]; other site 391735009707 Q-loop/lid; other site 391735009708 ABC transporter signature motif; other site 391735009709 Walker B; other site 391735009710 D-loop; other site 391735009711 H-loop/switch region; other site 391735009712 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735009713 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 391735009714 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 391735009715 dimer interface [polypeptide binding]; other site 391735009716 active site 391735009717 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391735009718 substrate binding site [chemical binding]; other site 391735009719 catalytic residue [active] 391735009720 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391735009721 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 391735009722 putative active site [active] 391735009723 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 391735009724 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 391735009725 active site 391735009726 putative substrate binding pocket [chemical binding]; other site 391735009727 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391735009728 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 391735009729 Walker A/P-loop; other site 391735009730 ATP binding site [chemical binding]; other site 391735009731 Q-loop/lid; other site 391735009732 ABC transporter signature motif; other site 391735009733 Walker B; other site 391735009734 D-loop; other site 391735009735 H-loop/switch region; other site 391735009736 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735009737 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391735009738 substrate binding pocket [chemical binding]; other site 391735009739 membrane-bound complex binding site; other site 391735009740 hinge residues; other site 391735009741 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391735009742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735009743 dimer interface [polypeptide binding]; other site 391735009744 conserved gate region; other site 391735009745 putative PBP binding loops; other site 391735009746 ABC-ATPase subunit interface; other site 391735009747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735009748 dimer interface [polypeptide binding]; other site 391735009749 conserved gate region; other site 391735009750 putative PBP binding loops; other site 391735009751 ABC-ATPase subunit interface; other site 391735009752 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391735009753 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391735009754 DNA binding site [nucleotide binding] 391735009755 domain linker motif; other site 391735009756 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 391735009757 putative dimerization interface [polypeptide binding]; other site 391735009758 putative ligand binding site [chemical binding]; other site 391735009759 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735009760 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 391735009761 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391735009762 DNA-binding interface [nucleotide binding]; DNA binding site 391735009763 RelB antitoxin; Region: RelB; cl01171 391735009764 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 391735009765 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 391735009766 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 391735009767 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 391735009768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 391735009769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 391735009770 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 391735009771 Predicted transcriptional regulator [Transcription]; Region: COG3905 391735009772 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 391735009773 catalytic residues [active] 391735009774 catalytic nucleophile [active] 391735009775 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391735009776 DNA binding site [nucleotide binding] 391735009777 Int/Topo IB signature motif; other site 391735009778 active site 391735009779 Integrase core domain; Region: rve; cl01316 391735009780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735009781 active site 391735009782 Phosphotransferase enzyme family; Region: APH; pfam01636 391735009783 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 391735009784 phenyl proprionate permease family protein; Region: 2A0127; TIGR00902 391735009785 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 391735009786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 391735009787 LysE type translocator; Region: LysE; cl00565 391735009788 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735009789 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391735009790 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 391735009791 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 391735009792 active site 391735009793 HIGH motif; other site 391735009794 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 391735009795 active site 391735009796 KMSKS motif; other site 391735009797 amidophosphoribosyltransferase; Provisional; Region: PRK09246 391735009798 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 391735009799 active site 391735009800 tetramer interface [polypeptide binding]; other site 391735009801 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 391735009802 Colicin V production protein; Region: Colicin_V; cl00567 391735009803 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 391735009804 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391735009805 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391735009806 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 391735009807 putative catalytic residues [active] 391735009808 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 391735009809 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 391735009810 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 391735009811 dimer interface [polypeptide binding]; other site 391735009812 active site 391735009813 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391735009814 substrate binding site [chemical binding]; other site 391735009815 catalytic residue [active] 391735009816 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735009817 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391735009818 substrate binding pocket [chemical binding]; other site 391735009819 membrane-bound complex binding site; other site 391735009820 hinge residues; other site 391735009821 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391735009822 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 391735009823 Walker A/P-loop; other site 391735009824 ATP binding site [chemical binding]; other site 391735009825 Q-loop/lid; other site 391735009826 ABC transporter signature motif; other site 391735009827 Walker B; other site 391735009828 D-loop; other site 391735009829 H-loop/switch region; other site 391735009830 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391735009831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735009832 dimer interface [polypeptide binding]; other site 391735009833 conserved gate region; other site 391735009834 putative PBP binding loops; other site 391735009835 ABC-ATPase subunit interface; other site 391735009836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735009837 dimer interface [polypeptide binding]; other site 391735009838 conserved gate region; other site 391735009839 putative PBP binding loops; other site 391735009840 ABC-ATPase subunit interface; other site 391735009841 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 391735009842 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735009843 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 391735009844 DNA binding residues [nucleotide binding] 391735009845 dimerization interface [polypeptide binding]; other site 391735009846 putative transposase OrfB; Reviewed; Region: PHA02517 391735009847 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 391735009848 dimer interface [polypeptide binding]; other site 391735009849 putative metal binding site [ion binding]; other site 391735009850 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391735009851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735009852 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391735009853 metal binding site 2 [ion binding]; metal-binding site 391735009854 putative DNA binding helix; other site 391735009855 metal binding site 1 [ion binding]; metal-binding site 391735009856 dimer interface [polypeptide binding]; other site 391735009857 structural Zn2+ binding site [ion binding]; other site 391735009858 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 391735009859 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 391735009860 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 391735009861 ABC-ATPase subunit interface; other site 391735009862 dimer interface [polypeptide binding]; other site 391735009863 putative PBP binding regions; other site 391735009864 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 391735009865 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 391735009866 intersubunit interface [polypeptide binding]; other site 391735009867 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 391735009868 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 391735009869 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391735009870 FtsX-like permease family; Region: FtsX; pfam02687 391735009871 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391735009872 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 391735009873 Walker A/P-loop; other site 391735009874 ATP binding site [chemical binding]; other site 391735009875 Q-loop/lid; other site 391735009876 ABC transporter signature motif; other site 391735009877 Walker B; other site 391735009878 D-loop; other site 391735009879 H-loop/switch region; other site 391735009880 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 391735009881 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391735009882 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735009883 DNA-binding site [nucleotide binding]; DNA binding site 391735009884 FCD domain; Region: FCD; cl11656 391735009885 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 391735009886 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily...; Region: MM_CoA_mutase_alpha_like; cd03679 391735009887 active site 391735009888 substrate binding site [chemical binding]; other site 391735009889 coenzyme B12 binding site [chemical binding]; other site 391735009890 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 391735009891 B12 binding site [chemical binding]; other site 391735009892 cobalt ligand [ion binding]; other site 391735009893 membrane ATPase/protein kinase; Provisional; Region: PRK09435 391735009894 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 391735009895 Walker A; other site 391735009896 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 391735009897 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735009898 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735009899 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 391735009900 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391735009901 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735009902 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 391735009903 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 391735009904 carboxyltransferase (CT) interaction site; other site 391735009905 biotinylation site [posttranslational modification]; other site 391735009906 Dehydratase family; Region: ILVD_EDD; cl00340 391735009907 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 391735009908 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 391735009909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735009910 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735009911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735009912 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735009913 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 391735009914 dimer interface [polypeptide binding]; other site 391735009915 substrate binding site [chemical binding]; other site 391735009916 metal binding site [ion binding]; metal-binding site 391735009917 cystathionine beta-lyase; Provisional; Region: PRK07050 391735009918 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735009919 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735009920 catalytic residue [active] 391735009921 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 391735009922 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 391735009923 active site 391735009924 catalytic triad [active] 391735009925 oxyanion hole [active] 391735009926 switch loop; other site 391735009927 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 391735009928 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 391735009929 Walker A/P-loop; other site 391735009930 ATP binding site [chemical binding]; other site 391735009931 Q-loop/lid; other site 391735009932 ABC transporter signature motif; other site 391735009933 Walker B; other site 391735009934 D-loop; other site 391735009935 H-loop/switch region; other site 391735009936 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 391735009937 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 391735009938 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 391735009939 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391735009940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735009941 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391735009942 substrate binding site [chemical binding]; other site 391735009943 ATP binding site [chemical binding]; other site 391735009944 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735009945 TM-ABC transporter signature motif; other site 391735009946 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735009947 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735009948 Walker A/P-loop; other site 391735009949 ATP binding site [chemical binding]; other site 391735009950 Q-loop/lid; other site 391735009951 ABC transporter signature motif; other site 391735009952 Walker B; other site 391735009953 D-loop; other site 391735009954 H-loop/switch region; other site 391735009955 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735009956 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391735009957 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 391735009958 putative ligand binding site [chemical binding]; other site 391735009959 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391735009960 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735009961 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 391735009962 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 391735009963 metal binding site [ion binding]; metal-binding site 391735009964 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 391735009965 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735009966 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735009967 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 391735009968 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735009969 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735009970 Walker A/P-loop; other site 391735009971 ATP binding site [chemical binding]; other site 391735009972 Q-loop/lid; other site 391735009973 ABC transporter signature motif; other site 391735009974 Walker B; other site 391735009975 D-loop; other site 391735009976 H-loop/switch region; other site 391735009977 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735009978 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391735009979 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735009980 Walker A/P-loop; other site 391735009981 ATP binding site [chemical binding]; other site 391735009982 Q-loop/lid; other site 391735009983 ABC transporter signature motif; other site 391735009984 Walker B; other site 391735009985 D-loop; other site 391735009986 H-loop/switch region; other site 391735009987 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735009988 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496 391735009989 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735009990 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735009991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735009992 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391735009993 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391735009994 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735009995 TM-ABC transporter signature motif; other site 391735009996 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391735009997 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735009998 Walker A/P-loop; other site 391735009999 ATP binding site [chemical binding]; other site 391735010000 Q-loop/lid; other site 391735010001 ABC transporter signature motif; other site 391735010002 Walker B; other site 391735010003 D-loop; other site 391735010004 H-loop/switch region; other site 391735010005 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391735010006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735010007 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 391735010008 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391735010009 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 391735010010 AP (apurinic/apyrimidinic) site pocket; other site 391735010011 DNA interaction; other site 391735010012 Metal-binding active site; metal-binding site 391735010013 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391735010014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735010015 dimer interface [polypeptide binding]; other site 391735010016 conserved gate region; other site 391735010017 ABC-ATPase subunit interface; other site 391735010018 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 391735010019 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735010020 acyl-CoA synthetase; Validated; Region: PRK06178 391735010021 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735010022 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735010023 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391735010024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735010025 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735010026 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 391735010027 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735010028 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735010029 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735010030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735010031 Bacterial transcriptional regulator; Region: IclR; pfam01614 391735010032 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 391735010033 active site 391735010034 metal binding site [ion binding]; metal-binding site 391735010035 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 391735010036 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 391735010037 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391735010038 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391735010039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735010040 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391735010041 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 391735010042 Walker A/P-loop; other site 391735010043 ATP binding site [chemical binding]; other site 391735010044 Q-loop/lid; other site 391735010045 ABC transporter signature motif; other site 391735010046 Walker B; other site 391735010047 D-loop; other site 391735010048 H-loop/switch region; other site 391735010049 TOBE domain; Region: TOBE_2; cl01440 391735010050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735010051 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391735010052 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 391735010053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735010054 dimer interface [polypeptide binding]; other site 391735010055 conserved gate region; other site 391735010056 putative PBP binding loops; other site 391735010057 ABC-ATPase subunit interface; other site 391735010058 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735010059 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391735010060 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 391735010061 Walker A/P-loop; other site 391735010062 ATP binding site [chemical binding]; other site 391735010063 Q-loop/lid; other site 391735010064 ABC transporter signature motif; other site 391735010065 Walker B; other site 391735010066 D-loop; other site 391735010067 H-loop/switch region; other site 391735010068 TOBE domain; Region: TOBE_2; cl01440 391735010069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735010070 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391735010071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735010072 dimer interface [polypeptide binding]; other site 391735010073 conserved gate region; other site 391735010074 putative PBP binding loops; other site 391735010075 ABC-ATPase subunit interface; other site 391735010076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735010077 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 391735010078 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 391735010079 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 391735010080 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391735010081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735010082 DNA-binding site [nucleotide binding]; DNA binding site 391735010083 FCD domain; Region: FCD; cl11656 391735010084 argininosuccinate synthase; Region: argG; TIGR00032 391735010085 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 391735010086 Ligand Binding Site [chemical binding]; other site 391735010087 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 391735010088 FAD binding domain; Region: FAD_binding_4; pfam01565 391735010089 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 391735010090 Protein of unknown function (DUF520); Region: DUF520; cl00723 391735010091 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 391735010092 catalytic motif [active] 391735010093 Catalytic residue [active] 391735010094 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 391735010095 Domain of unknown function (DUF205); Region: DUF205; cl00410 391735010096 Replication initiator protein A; Region: RPA; cl02339 391735010097 Replication initiator protein A; Region: RPA; cl02339 391735010098 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 391735010099 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 391735010100 oligomeric interface; other site 391735010101 putative active site [active] 391735010102 homodimer interface [polypeptide binding]; other site 391735010103 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 391735010104 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 391735010105 active site 391735010106 catalytic tetrad [active] 391735010107 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 391735010108 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735010109 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735010110 catalytic residue [active] 391735010111 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391735010112 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 391735010113 Walker A/P-loop; other site 391735010114 ATP binding site [chemical binding]; other site 391735010115 Q-loop/lid; other site 391735010116 ABC transporter signature motif; other site 391735010117 Walker B; other site 391735010118 D-loop; other site 391735010119 H-loop/switch region; other site 391735010120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735010121 dimer interface [polypeptide binding]; other site 391735010122 conserved gate region; other site 391735010123 putative PBP binding loops; other site 391735010124 ABC-ATPase subunit interface; other site 391735010125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735010126 dimer interface [polypeptide binding]; other site 391735010127 conserved gate region; other site 391735010128 putative PBP binding loops; other site 391735010129 ABC-ATPase subunit interface; other site 391735010130 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391735010131 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735010132 substrate binding pocket [chemical binding]; other site 391735010133 membrane-bound complex binding site; other site 391735010134 hinge residues; other site 391735010135 Cysteine dioxygenase type I; Region: CDO_I; cl02350 391735010136 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391735010137 active site residue [active] 391735010138 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391735010139 active site residue [active] 391735010140 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 391735010141 active site residue [active] 391735010142 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391735010143 active site residue [active] 391735010144 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735010145 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735010146 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735010147 dimerization interface [polypeptide binding]; other site 391735010148 Restriction endonuclease [Defense mechanisms]; Region: COG3587 391735010149 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 391735010150 HerA helicase [Replication, recombination, and repair]; Region: COG0433 391735010151 Domain of unknown function DUF87; Region: DUF87; pfam01935 391735010152 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 391735010153 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 391735010154 putative active site [active] 391735010155 catalytic site [active] 391735010156 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 391735010157 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735010158 ATP binding site [chemical binding]; other site 391735010159 putative Mg++ binding site [ion binding]; other site 391735010160 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391735010161 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 391735010162 active site 391735010163 metal binding site [ion binding]; metal-binding site 391735010164 Catalytic domain of Protein Kinases; Region: PKc; cd00180 391735010165 active site 391735010166 ATP binding site [chemical binding]; other site 391735010167 substrate binding site [chemical binding]; other site 391735010168 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 391735010169 activation loop (A-loop); other site 391735010170 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391735010171 Ligand Binding Site [chemical binding]; other site 391735010172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735010173 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735010174 enoyl-CoA hydratase; Provisional; Region: PRK08252 391735010175 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735010176 substrate binding site [chemical binding]; other site 391735010177 oxyanion hole (OAH) forming residues; other site 391735010178 trimer interface [polypeptide binding]; other site 391735010179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735010180 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 391735010181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735010182 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735010183 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 391735010184 DNA binding site [nucleotide binding] 391735010185 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 391735010186 active site 391735010187 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 391735010188 DNA binding site [nucleotide binding] 391735010189 arginine decarboxylase; Provisional; Region: PRK15029 391735010190 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 391735010191 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735010192 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735010193 catalytic residue [active] 391735010194 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 391735010195 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 391735010196 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 391735010197 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735010198 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735010199 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735010200 dimerization interface [polypeptide binding]; other site 391735010201 Ferredoxin [Energy production and conversion]; Region: COG1146 391735010202 4Fe-4S binding domain; Region: Fer4; cl02805 391735010203 enoyl-CoA hydratase; Provisional; Region: PRK06494 391735010204 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735010205 substrate binding site [chemical binding]; other site 391735010206 oxyanion hole (OAH) forming residues; other site 391735010207 trimer interface [polypeptide binding]; other site 391735010208 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735010209 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 391735010210 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391735010211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735010212 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391735010213 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 391735010214 Walker A/P-loop; other site 391735010215 ATP binding site [chemical binding]; other site 391735010216 Q-loop/lid; other site 391735010217 ABC transporter signature motif; other site 391735010218 Walker B; other site 391735010219 D-loop; other site 391735010220 H-loop/switch region; other site 391735010221 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391735010222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735010223 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 391735010224 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735010225 NAD binding site [chemical binding]; other site 391735010226 catalytic residues [active] 391735010227 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 391735010228 dimerization interface [polypeptide binding]; other site 391735010229 putative catalytic residue [active] 391735010230 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 391735010231 putative active site pocket [active] 391735010232 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 391735010233 active site 391735010234 Protein of unknown function (DUF779); Region: DUF779; cl01432 391735010235 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 391735010236 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735010237 NAD(P) binding site [chemical binding]; other site 391735010238 catalytic residues [active] 391735010239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735010240 Restriction endonuclease PvuII; Region: Endonuc-PvuII; pfam09225 391735010241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735010242 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 391735010243 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 391735010244 general secretion pathway protein I; Region: gspI; TIGR01707 391735010245 Bacterial type II secretion system protein I/J; Region: GSPII_IJ; pfam02501 391735010246 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 391735010247 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 391735010248 General secretion pathway protein K; Region: GspK; pfam03934 391735010249 general secretion pathway protein L; Region: typeII_sec_gspL; TIGR01709 391735010250 GspL cytoplasmic actin-ATPase-like region; Region: GspL; pfam05134 391735010251 diacylglycerol kinase; Reviewed; Region: PRK11914 391735010252 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 391735010253 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 391735010254 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 391735010255 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 391735010256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735010257 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735010258 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 391735010259 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 391735010260 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 391735010261 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735010262 tetrameric interface [polypeptide binding]; other site 391735010263 NAD binding site [chemical binding]; other site 391735010264 catalytic residues [active] 391735010265 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735010266 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735010267 Walker A/P-loop; other site 391735010268 ATP binding site [chemical binding]; other site 391735010269 Q-loop/lid; other site 391735010270 ABC transporter signature motif; other site 391735010271 Walker B; other site 391735010272 D-loop; other site 391735010273 H-loop/switch region; other site 391735010274 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735010275 Strictosidine synthase; Region: Str_synth; pfam03088 391735010276 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735010277 TM-ABC transporter signature motif; other site 391735010278 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 391735010279 Strictosidine synthase; Region: Str_synth; pfam03088 391735010280 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391735010281 ligand binding site [chemical binding]; other site 391735010282 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735010283 TM-ABC transporter signature motif; other site 391735010284 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735010285 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735010286 active site 391735010287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735010288 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 391735010289 Dehydratase family; Region: ILVD_EDD; cl00340 391735010290 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 391735010291 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 391735010292 inhibitor site; inhibition site 391735010293 active site 391735010294 dimer interface [polypeptide binding]; other site 391735010295 catalytic residue [active] 391735010296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735010297 putative substrate translocation pore; other site 391735010298 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735010299 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735010300 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735010301 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 391735010302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735010303 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735010304 HsdM N-terminal domain; Region: HsdM_N; pfam12161 391735010305 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 391735010306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735010307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735010308 Protein of unknown function (DUF1016); Region: DUF1016; cl01979 391735010309 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 391735010310 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 391735010311 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 391735010312 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 391735010313 Domain of unknown function (DUF955); Region: DUF955; cl01076 391735010314 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 391735010315 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 391735010316 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735010317 ATP binding site [chemical binding]; other site 391735010318 putative Mg++ binding site [ion binding]; other site 391735010319 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 391735010320 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 391735010321 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 391735010322 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 391735010323 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735010324 classical (c) SDRs; Region: SDR_c; cd05233 391735010325 NAD(P) binding site [chemical binding]; other site 391735010326 active site 391735010327 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 391735010328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735010329 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 391735010330 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391735010331 substrate binding site [chemical binding]; other site 391735010332 ATP binding site [chemical binding]; other site 391735010333 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 391735010334 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 391735010335 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 391735010336 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 391735010337 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 391735010338 putative active site pocket [active] 391735010339 putative metal binding site [ion binding]; other site 391735010340 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391735010341 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 391735010342 Walker A/P-loop; other site 391735010343 ATP binding site [chemical binding]; other site 391735010344 Q-loop/lid; other site 391735010345 ABC transporter signature motif; other site 391735010346 Walker B; other site 391735010347 D-loop; other site 391735010348 H-loop/switch region; other site 391735010349 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391735010350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735010351 dimer interface [polypeptide binding]; other site 391735010352 conserved gate region; other site 391735010353 putative PBP binding loops; other site 391735010354 ABC-ATPase subunit interface; other site 391735010355 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391735010356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735010357 dimer interface [polypeptide binding]; other site 391735010358 conserved gate region; other site 391735010359 putative PBP binding loops; other site 391735010360 ABC-ATPase subunit interface; other site 391735010361 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 391735010362 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 391735010363 putative NAD(P) binding site [chemical binding]; other site 391735010364 catalytic Zn binding site [ion binding]; other site 391735010365 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 391735010366 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735010367 substrate binding pocket [chemical binding]; other site 391735010368 membrane-bound complex binding site; other site 391735010369 hinge residues; other site 391735010370 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391735010371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735010372 DNA-binding site [nucleotide binding]; DNA binding site 391735010373 FCD domain; Region: FCD; cl11656 391735010374 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391735010375 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391735010376 DNA binding site [nucleotide binding] 391735010377 domain linker motif; other site 391735010378 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 391735010379 putative ligand binding site [chemical binding]; other site 391735010380 putative dimerization interface [polypeptide binding]; other site 391735010381 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391735010382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735010383 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 391735010384 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 391735010385 Coenzyme A transferase; Region: CoA_trans; cl00773 391735010386 Coenzyme A transferase; Region: CoA_trans; cl00773 391735010387 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735010388 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 391735010389 substrate binding site [chemical binding]; other site 391735010390 oxyanion hole (OAH) forming residues; other site 391735010391 trimer interface [polypeptide binding]; other site 391735010392 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735010393 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 391735010394 NAD(P) binding site [chemical binding]; other site 391735010395 catalytic residues [active] 391735010396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735010397 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 391735010398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735010399 putative PBP binding loops; other site 391735010400 ABC-ATPase subunit interface; other site 391735010401 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391735010402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735010403 dimer interface [polypeptide binding]; other site 391735010404 conserved gate region; other site 391735010405 ABC-ATPase subunit interface; other site 391735010406 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391735010407 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 391735010408 Walker A/P-loop; other site 391735010409 ATP binding site [chemical binding]; other site 391735010410 Q-loop/lid; other site 391735010411 ABC transporter signature motif; other site 391735010412 Walker B; other site 391735010413 D-loop; other site 391735010414 H-loop/switch region; other site 391735010415 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 391735010416 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391735010417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735010418 NAD(P) binding site [chemical binding]; other site 391735010419 active site 391735010420 choline dehydrogenase; Validated; Region: PRK02106 391735010421 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391735010422 Protein of unknown function (DUF993); Region: DUF993; pfam06187 391735010423 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391735010424 hydrophobic ligand binding site; other site 391735010425 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391735010426 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 391735010427 FMN-binding pocket [chemical binding]; other site 391735010428 flavin binding motif; other site 391735010429 phosphate binding motif [ion binding]; other site 391735010430 beta-alpha-beta structure motif; other site 391735010431 NAD binding pocket [chemical binding]; other site 391735010432 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735010433 catalytic loop [active] 391735010434 iron binding site [ion binding]; other site 391735010435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735010436 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735010437 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391735010438 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 391735010439 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735010440 enoyl-CoA hydratase; Provisional; Region: PRK08138 391735010441 substrate binding site [chemical binding]; other site 391735010442 oxyanion hole (OAH) forming residues; other site 391735010443 trimer interface [polypeptide binding]; other site 391735010444 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735010445 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735010446 classical (c) SDRs; Region: SDR_c; cd05233 391735010447 NAD(P) binding site [chemical binding]; other site 391735010448 active site 391735010449 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735010450 TM-ABC transporter signature motif; other site 391735010451 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735010452 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735010453 Walker A/P-loop; other site 391735010454 ATP binding site [chemical binding]; other site 391735010455 Q-loop/lid; other site 391735010456 ABC transporter signature motif; other site 391735010457 Walker B; other site 391735010458 D-loop; other site 391735010459 H-loop/switch region; other site 391735010460 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735010461 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735010462 TM-ABC transporter signature motif; other site 391735010463 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391735010464 ligand binding site [chemical binding]; other site 391735010465 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 391735010466 Clp amino terminal domain; Region: Clp_N; pfam02861 391735010467 Clp amino terminal domain; Region: Clp_N; pfam02861 391735010468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735010469 Walker A motif; other site 391735010470 ATP binding site [chemical binding]; other site 391735010471 Walker B motif; other site 391735010472 arginine finger; other site 391735010473 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735010474 Walker A motif; other site 391735010475 ATP binding site [chemical binding]; other site 391735010476 Walker B motif; other site 391735010477 arginine finger; other site 391735010478 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 391735010479 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391735010480 NAD(P) binding site [chemical binding]; other site 391735010481 catalytic residues [active] 391735010482 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 391735010483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391735010484 Coenzyme A binding pocket [chemical binding]; other site 391735010485 Fe2+ transport protein; Region: Iron_transport; cl01377 391735010486 Iron permease FTR1 family; Region: FTR1; cl00475 391735010487 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 391735010488 4Fe-4S binding domain; Region: Fer4_5; pfam12801 391735010489 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 391735010490 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal...; Region: PurM-like; cl10019 391735010491 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 391735010492 dimerization interface [polypeptide binding]; other site 391735010493 ATP binding site [chemical binding]; other site 391735010494 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 391735010495 dimerization interface [polypeptide binding]; other site 391735010496 ATP binding site [chemical binding]; other site 391735010497 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 391735010498 putative active site [active] 391735010499 catalytic triad [active] 391735010500 methionine aminopeptidase; Reviewed; Region: PRK07281 391735010501 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 391735010502 active site 391735010503 PII uridylyl-transferase; Provisional; Region: PRK03059 391735010504 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391735010505 metal binding triad; other site 391735010506 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 391735010507 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 391735010508 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 391735010509 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 391735010510 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 391735010511 active site 391735010512 catalytic residues [active] 391735010513 metal binding site [ion binding]; metal-binding site 391735010514 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 391735010515 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 391735010516 molybdopterin cofactor binding site [chemical binding]; other site 391735010517 substrate binding site [chemical binding]; other site 391735010518 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 391735010519 molybdopterin cofactor binding site; other site 391735010520 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 391735010521 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735010522 Coenzyme A transferase; Region: CoA_trans; cl00773 391735010523 Coenzyme A transferase; Region: CoA_trans; cl00773 391735010524 Cysteine dioxygenase type I; Region: CDO_I; cl02350 391735010525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735010526 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735010527 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 391735010528 putative dimerization interface [polypeptide binding]; other site 391735010529 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735010530 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735010531 active site 391735010532 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 391735010533 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 391735010534 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 391735010535 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 391735010536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735010537 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735010538 Bacterial transcriptional regulator; Region: IclR; pfam01614 391735010539 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 391735010540 Beta-lactamase; Region: Beta-lactamase; cl01009 391735010541 2-isopropylmalate synthase; Validated; Region: PRK00915 391735010542 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 391735010543 active site 391735010544 catalytic residues [active] 391735010545 metal binding site [ion binding]; metal-binding site 391735010546 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 391735010547 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 391735010548 MoaE homodimer interface [polypeptide binding]; other site 391735010549 MoaD interaction [polypeptide binding]; other site 391735010550 active site residues [active] 391735010551 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 391735010552 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391735010553 catalytic residue [active] 391735010554 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 391735010555 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391735010556 CoenzymeA binding site [chemical binding]; other site 391735010557 subunit interaction site [polypeptide binding]; other site 391735010558 PHB binding site; other site 391735010559 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 391735010560 Fic/DOC family; Region: Fic; cl00960 391735010561 Fic/DOC family; Region: Fic; cl00960 391735010562 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 391735010563 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 391735010564 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 391735010565 N-terminal plug; other site 391735010566 ligand-binding site [chemical binding]; other site 391735010567 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391735010568 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735010569 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391735010570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735010571 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391735010572 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 391735010573 Walker A/P-loop; other site 391735010574 ATP binding site [chemical binding]; other site 391735010575 Q-loop/lid; other site 391735010576 ABC transporter signature motif; other site 391735010577 Walker B; other site 391735010578 D-loop; other site 391735010579 H-loop/switch region; other site 391735010580 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 391735010581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735010582 DNA-binding site [nucleotide binding]; DNA binding site 391735010583 UTRA domain; Region: UTRA; cl06649 391735010584 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 391735010585 active sites [active] 391735010586 tetramer interface [polypeptide binding]; other site 391735010587 urocanate hydratase; Provisional; Region: PRK05414 391735010588 urocanate hydratase; Region: hutU; TIGR01228 391735010589 HutD; Region: HutD; cl01532 391735010590 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 391735010591 active site 391735010592 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 391735010593 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 391735010594 active site 391735010595 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391735010596 seryl-tRNA synthetase; Provisional; Region: PRK05431 391735010597 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 391735010598 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 391735010599 dimer interface [polypeptide binding]; other site 391735010600 active site 391735010601 motif 1; other site 391735010602 motif 2; other site 391735010603 motif 3; other site 391735010604 integrase; Provisional; Region: PRK09692 391735010605 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 391735010606 active site 391735010607 Int/Topo IB signature motif; other site 391735010608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735010609 cofactor binding site; other site 391735010610 DNA binding site [nucleotide binding] 391735010611 substrate interaction site [chemical binding]; other site 391735010612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735010613 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 391735010614 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 391735010615 active site 391735010616 catalytic site [active] 391735010617 substrate binding site [chemical binding]; other site 391735010618 exodeoxyribonuclease X; Provisional; Region: PRK07983 391735010619 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391735010620 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 391735010621 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 391735010622 PRTRC system protein D; Region: PRTRC_D; TIGR03739 391735010623 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 391735010624 DEAD_2; Region: DEAD_2; cl14887 391735010625 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 391735010626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 391735010627 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 391735010628 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 391735010629 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 391735010630 UvrD/REP helicase; Region: UvrD-helicase; cl14126 391735010631 UvrD/REP helicase; Region: UvrD-helicase; cl14126 391735010632 Transposase domain (DUF772); Region: DUF772; cl12084 391735010633 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735010634 Active site [active] 391735010635 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 391735010636 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735010637 ATP binding site [chemical binding]; other site 391735010638 putative Mg++ binding site [ion binding]; other site 391735010639 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391735010640 nucleotide binding region [chemical binding]; other site 391735010641 ATP-binding site [chemical binding]; other site 391735010642 Staphylococcal nuclease homologues; Region: SNc; smart00318 391735010643 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 391735010644 Catalytic site; other site 391735010645 Domain of unknown function (DUF932); Region: DUF932; cl12129 391735010646 Peptidase M15; Region: Peptidase_M15_3; cl01194 391735010647 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 391735010648 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 391735010649 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391735010650 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 391735010651 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 391735010652 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 391735010653 VirB7 interaction site; other site 391735010654 VirB8 protein; Region: VirB8; cl01500 391735010655 PilS N terminal; Region: PilS; pfam08805 391735010656 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 391735010657 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 391735010658 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735010659 Walker A motif; other site 391735010660 ATP binding site [chemical binding]; other site 391735010661 Walker B motif; other site 391735010662 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 391735010663 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 391735010664 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 391735010665 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 391735010666 VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 391735010667 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 391735010668 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735010669 Walker A motif; other site 391735010670 ATP binding site [chemical binding]; other site 391735010671 Walker B motif; other site 391735010672 Nuclease-related domain; Region: NERD; pfam08378 391735010673 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 391735010674 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 391735010675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735010676 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; cl02021 391735010677 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391735010678 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cl02940 391735010679 DNA polymerase sliding clamp subunit (PCNA homolog) [DNA replication, recombination, and repair]; Region: DnaN; COG0592 391735010680 putative DNA binding surface [nucleotide binding]; other site 391735010681 dimer interface [polypeptide binding]; other site 391735010682 beta-clamp/translesion DNA polymerase binding surface; other site 391735010683 beta-clamp/clamp loader binding surface; other site 391735010684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 391735010685 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; cl07038 391735010686 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 391735010687 dimer interface [polypeptide binding]; other site 391735010688 ssDNA binding site [nucleotide binding]; other site 391735010689 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391735010690 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 391735010691 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735010692 Walker A/P-loop; other site 391735010693 ATP binding site [chemical binding]; other site 391735010694 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 391735010695 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735010696 Q-loop/lid; other site 391735010697 ABC transporter signature motif; other site 391735010698 Walker B; other site 391735010699 D-loop; other site 391735010700 H-loop/switch region; other site 391735010701 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 391735010702 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 391735010703 active site 391735010704 metal binding site [ion binding]; metal-binding site 391735010705 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 391735010706 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735010707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735010708 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391735010709 Walker A motif; other site 391735010710 ATP binding site [chemical binding]; other site 391735010711 Walker B motif; other site 391735010712 arginine finger; other site 391735010713 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 391735010714 active site 391735010715 catalytic triad [active] 391735010716 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 391735010717 Domain of unknown function (DUF955); Region: DUF955; cl01076 391735010718 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 391735010719 UvrD/REP helicase; Region: UvrD-helicase; cl14126 391735010720 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 391735010721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735010722 ATP binding site [chemical binding]; other site 391735010723 substrate interface [chemical binding]; other site 391735010724 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 391735010725 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 391735010726 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 391735010727 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 391735010728 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 391735010729 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 391735010730 Ligand Binding Site [chemical binding]; other site 391735010731 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 391735010732 Active Sites [active] 391735010733 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 391735010734 UvrD/REP helicase; Region: UvrD-helicase; cl14126 391735010735 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 391735010736 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 391735010737 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 391735010738 Di-iron ligands [ion binding]; other site 391735010739 acyl-CoA synthetase; Validated; Region: PRK05850 391735010740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735010741 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 391735010742 dimerization interface [polypeptide binding]; other site 391735010743 substrate binding pocket [chemical binding]; other site 391735010744 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 391735010745 oligomeric interface; other site 391735010746 putative active site [active] 391735010747 homodimer interface [polypeptide binding]; other site 391735010748 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 391735010749 conjugal transfer relaxase TraI; Provisional; Region: PRK13878 391735010750 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 391735010751 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 391735010752 C-terminal domain interface [polypeptide binding]; other site 391735010753 GSH binding site (G-site) [chemical binding]; other site 391735010754 dimer interface [polypeptide binding]; other site 391735010755 GST_C family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_C_Ure2p_like; cd03178 391735010756 dimer interface [polypeptide binding]; other site 391735010757 N-terminal domain interface [polypeptide binding]; other site 391735010758 putative substrate binding pocket (H-site) [chemical binding]; other site 391735010759 galactonate dehydratase; Provisional; Region: PRK14017 391735010760 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 391735010761 putative active site pocket [active] 391735010762 putative metal binding site [ion binding]; other site 391735010763 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 391735010764 active site 391735010765 intersubunit interface [polypeptide binding]; other site 391735010766 catalytic residue [active] 391735010767 short chain dehydrogenase; Provisional; Region: PRK07063 391735010768 classical (c) SDRs; Region: SDR_c; cd05233 391735010769 NAD(P) binding site [chemical binding]; other site 391735010770 active site 391735010771 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735010772 TM-ABC transporter signature motif; other site 391735010773 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 391735010774 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735010775 Walker A/P-loop; other site 391735010776 ATP binding site [chemical binding]; other site 391735010777 Q-loop/lid; other site 391735010778 ABC transporter signature motif; other site 391735010779 Walker B; other site 391735010780 D-loop; other site 391735010781 H-loop/switch region; other site 391735010782 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735010783 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 391735010784 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 391735010785 ligand binding site [chemical binding]; other site 391735010786 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 391735010787 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 391735010788 FOG: CBS domain [General function prediction only]; Region: COG0517 391735010789 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 391735010790 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 391735010791 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 391735010792 homodimer interface [polypeptide binding]; other site 391735010793 substrate-cofactor binding pocket; other site 391735010794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735010795 catalytic residue [active] 391735010796 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735010797 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391735010798 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 391735010799 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 391735010800 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391735010801 FAD binding domain; Region: FAD_binding_4; pfam01565 391735010802 Chromate transporter; Region: Chromate_transp; pfam02417 391735010803 Chromate transporter; Region: Chromate_transp; pfam02417 391735010804 ykkC-yxkD element as predicted by Rfam (RF00442), score 56.50 391735010805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735010806 dimer interface [polypeptide binding]; other site 391735010807 conserved gate region; other site 391735010808 putative PBP binding loops; other site 391735010809 ABC-ATPase subunit interface; other site 391735010810 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391735010811 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 391735010812 Walker A/P-loop; other site 391735010813 ATP binding site [chemical binding]; other site 391735010814 Q-loop/lid; other site 391735010815 ABC transporter signature motif; other site 391735010816 Walker B; other site 391735010817 D-loop; other site 391735010818 H-loop/switch region; other site 391735010819 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 391735010820 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 391735010821 urea carboxylase; Region: urea_carbox; TIGR02712 391735010822 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391735010823 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735010824 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 391735010825 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 391735010826 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 391735010827 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 391735010828 carboxyltransferase (CT) interaction site; other site 391735010829 biotinylation site [posttranslational modification]; other site 391735010830 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 391735010831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735010832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735010833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735010834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735010835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735010836 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735010837 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735010838 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 391735010839 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 391735010840 dimer interface [polypeptide binding]; other site 391735010841 PYR/PP interface [polypeptide binding]; other site 391735010842 TPP binding site [chemical binding]; other site 391735010843 substrate binding site [chemical binding]; other site 391735010844 TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the...; Region: TPP_IOR_alpha; cd02008 391735010845 TPP-binding site; other site 391735010846 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 391735010847 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 391735010848 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391735010849 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735010850 DNA-binding site [nucleotide binding]; DNA binding site 391735010851 SAF domain; Region: SAF; cl00555 391735010852 SAF domain; Region: SAF; cl00555 391735010853 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 391735010854 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 391735010855 NAD(P) binding site [chemical binding]; other site 391735010856 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 391735010857 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 391735010858 Sodium:solute symporter family; Region: SSF; cl00456 391735010859 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 391735010860 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 391735010861 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735010862 Walker A/P-loop; other site 391735010863 ATP binding site [chemical binding]; other site 391735010864 Q-loop/lid; other site 391735010865 ABC transporter signature motif; other site 391735010866 Walker B; other site 391735010867 D-loop; other site 391735010868 H-loop/switch region; other site 391735010869 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735010870 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735010871 Walker A/P-loop; other site 391735010872 ATP binding site [chemical binding]; other site 391735010873 Q-loop/lid; other site 391735010874 ABC transporter signature motif; other site 391735010875 Walker B; other site 391735010876 D-loop; other site 391735010877 H-loop/switch region; other site 391735010878 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735010879 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 391735010880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735010881 dimer interface [polypeptide binding]; other site 391735010882 conserved gate region; other site 391735010883 putative PBP binding loops; other site 391735010884 ABC-ATPase subunit interface; other site 391735010885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735010886 dimer interface [polypeptide binding]; other site 391735010887 conserved gate region; other site 391735010888 ABC-ATPase subunit interface; other site 391735010889 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 391735010890 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 391735010891 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 391735010892 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 391735010893 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 391735010894 NAD binding site [chemical binding]; other site 391735010895 homotetramer interface [polypeptide binding]; other site 391735010896 homodimer interface [polypeptide binding]; other site 391735010897 substrate binding site [chemical binding]; other site 391735010898 active site 391735010899 hypothetical protein; Provisional; Region: PRK01254 391735010900 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 391735010901 Uncharacterized conserved protein [Function unknown]; Region: COG1739 391735010902 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 391735010903 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 391735010904 putative acyltransferase; Provisional; Region: PRK05790 391735010905 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391735010906 dimer interface [polypeptide binding]; other site 391735010907 active site 391735010908 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 391735010909 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 391735010910 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 391735010911 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 391735010912 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042 391735010913 maleylacetoacetate isomerase; Region: maiA; TIGR01262 391735010914 C-terminal domain interface [polypeptide binding]; other site 391735010915 GSH binding site (G-site) [chemical binding]; other site 391735010916 putative dimer interface [polypeptide binding]; other site 391735010917 GST_C family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_C_Zeta; cd03191 391735010918 dimer interface [polypeptide binding]; other site 391735010919 N-terminal domain interface [polypeptide binding]; other site 391735010920 putative maleylacetoacetate (MAA) substrate binding site (H site); other site 391735010921 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391735010922 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 391735010923 nudix motif; other site 391735010924 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 391735010925 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 391735010926 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 391735010927 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 391735010928 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 391735010929 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 391735010930 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 391735010931 Type II transport protein GspH; Region: GspH; pfam12019 391735010932 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 391735010933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735010934 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 391735010935 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735010936 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735010937 Walker A/P-loop; other site 391735010938 ATP binding site [chemical binding]; other site 391735010939 Q-loop/lid; other site 391735010940 ABC transporter signature motif; other site 391735010941 Walker B; other site 391735010942 D-loop; other site 391735010943 H-loop/switch region; other site 391735010944 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735010945 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735010946 Walker A/P-loop; other site 391735010947 ATP binding site [chemical binding]; other site 391735010948 Q-loop/lid; other site 391735010949 ABC transporter signature motif; other site 391735010950 Walker B; other site 391735010951 D-loop; other site 391735010952 H-loop/switch region; other site 391735010953 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 391735010954 putative ligand binding site [chemical binding]; other site 391735010955 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735010956 TM-ABC transporter signature motif; other site 391735010957 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735010958 TM-ABC transporter signature motif; other site 391735010959 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 391735010960 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735010961 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391735010962 enoyl-CoA hydratase; Provisional; Region: PRK06210 391735010963 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735010964 substrate binding site [chemical binding]; other site 391735010965 oxyanion hole (OAH) forming residues; other site 391735010966 trimer interface [polypeptide binding]; other site 391735010967 Transposase domain (DUF772); Region: DUF772; cl12084 391735010968 Integrase core domain; Region: rve; cl01316 391735010969 SOS regulatory protein LexA; Region: lexA; TIGR00498 391735010970 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735010971 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 391735010972 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735010973 Walker A/P-loop; other site 391735010974 ATP binding site [chemical binding]; other site 391735010975 Q-loop/lid; other site 391735010976 ABC transporter signature motif; other site 391735010977 Walker B; other site 391735010978 D-loop; other site 391735010979 H-loop/switch region; other site 391735010980 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735010981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735010982 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735010983 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735010984 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735010985 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735010986 Walker A/P-loop; other site 391735010987 ATP binding site [chemical binding]; other site 391735010988 Q-loop/lid; other site 391735010989 ABC transporter signature motif; other site 391735010990 Walker B; other site 391735010991 D-loop; other site 391735010992 H-loop/switch region; other site 391735010993 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735010994 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391735010995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735010996 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735010997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735010998 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391735010999 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 391735011000 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735011001 enoyl-CoA hydratase; Provisional; Region: PRK08252 391735011002 substrate binding site [chemical binding]; other site 391735011003 oxyanion hole (OAH) forming residues; other site 391735011004 trimer interface [polypeptide binding]; other site 391735011005 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391735011006 classical (c) SDRs; Region: SDR_c; cd05233 391735011007 NAD(P) binding site [chemical binding]; other site 391735011008 active site 391735011009 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 391735011010 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735011011 DUF35 OB-fold domain; Region: DUF35; pfam01796 391735011012 lipid-transfer protein; Provisional; Region: PRK08256 391735011013 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 391735011014 active site 391735011015 Integrase core domain; Region: rve; cl01316 391735011016 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 391735011017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735011018 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391735011019 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735011020 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735011021 Bacterial transcriptional regulator; Region: IclR; pfam01614 391735011022 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735011023 trimer interface [polypeptide binding]; other site 391735011024 oxyanion hole (OAH) forming residues; other site 391735011025 enoyl-CoA hydratase; Provisional; Region: PRK09076 391735011026 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735011027 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735011028 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 391735011029 active site 391735011030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735011031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735011032 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011033 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 391735011034 lipid-transfer protein; Provisional; Region: PRK08256 391735011035 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 391735011036 active site 391735011037 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 391735011038 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735011039 substrate binding site [chemical binding]; other site 391735011040 oxyanion hole (OAH) forming residues; other site 391735011041 trimer interface [polypeptide binding]; other site 391735011042 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391735011043 classical (c) SDRs; Region: SDR_c; cd05233 391735011044 NAD(P) binding site [chemical binding]; other site 391735011045 active site 391735011046 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 391735011047 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 391735011048 FMN binding site [chemical binding]; other site 391735011049 substrate binding site [chemical binding]; other site 391735011050 putative catalytic residue [active] 391735011051 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 391735011052 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735011053 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 391735011054 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 391735011055 active site 391735011056 NAD binding site [chemical binding]; other site 391735011057 metal binding site [ion binding]; metal-binding site 391735011058 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735011059 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391735011060 NAD(P) binding site [chemical binding]; other site 391735011061 catalytic residues [active] 391735011062 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 391735011063 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 391735011064 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735011065 Domain of unknown function (DU1801); Region: DUF1801; cl01838 391735011066 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 391735011067 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391735011068 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735011069 Walker A/P-loop; other site 391735011070 ATP binding site [chemical binding]; other site 391735011071 Q-loop/lid; other site 391735011072 ABC transporter signature motif; other site 391735011073 Walker B; other site 391735011074 D-loop; other site 391735011075 H-loop/switch region; other site 391735011076 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735011077 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735011078 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735011079 Walker A/P-loop; other site 391735011080 ATP binding site [chemical binding]; other site 391735011081 Q-loop/lid; other site 391735011082 ABC transporter signature motif; other site 391735011083 Walker B; other site 391735011084 D-loop; other site 391735011085 H-loop/switch region; other site 391735011086 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735011087 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 391735011088 putative active site [active] 391735011089 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391735011090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735011091 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735011092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735011093 dimer interface [polypeptide binding]; other site 391735011094 conserved gate region; other site 391735011095 putative PBP binding loops; other site 391735011096 ABC-ATPase subunit interface; other site 391735011097 Creatinine amidohydrolase; Region: Creatininase; cl00618 391735011098 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 391735011099 catalytic nucleophile [active] 391735011100 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391735011101 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 391735011102 putative active site [active] 391735011103 Uncharacterised protein family (UPF0125); Region: UPF0125; cl01096 391735011104 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 391735011105 putative coenzyme Q binding site [chemical binding]; other site 391735011106 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 391735011107 SmpB-tmRNA interface; other site 391735011108 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 391735011109 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 391735011110 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 391735011111 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 391735011112 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 391735011113 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 391735011114 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 391735011115 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 391735011116 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 391735011117 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 391735011118 Protein of unknown function, DUF655; Region: DUF655; cl00648 391735011119 tetratricopeptide repeat protein; Provisional; Region: PRK11788 391735011120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 391735011121 binding surface 391735011122 TPR motif; other site 391735011123 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 391735011124 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 391735011125 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings...; Region: proteasome_beta_bacterial; cd03765 391735011126 gamma-glutamyl kinase; Provisional; Region: PRK05429 391735011127 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 391735011128 nucleotide binding site [chemical binding]; other site 391735011129 homotetrameric interface [polypeptide binding]; other site 391735011130 putative phosphate binding site [ion binding]; other site 391735011131 putative allosteric binding site; other site 391735011132 PUA domain; Region: PUA; cl00607 391735011133 GTPase CgtA; Reviewed; Region: obgE; PRK12299 391735011134 GTP1/OBG; Region: GTP1_OBG; pfam01018 391735011135 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 391735011136 G1 box; other site 391735011137 GTP/Mg2+ binding site [chemical binding]; other site 391735011138 Switch I region; other site 391735011139 G2 box; other site 391735011140 G3 box; other site 391735011141 Switch II region; other site 391735011142 G4 box; other site 391735011143 G5 box; other site 391735011144 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 391735011145 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 391735011146 octaprenyl diphosphate synthase; Provisional; Region: PRK10888 391735011147 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 391735011148 substrate binding pocket [chemical binding]; other site 391735011149 chain length determination region; other site 391735011150 substrate-Mg2+ binding site; other site 391735011151 catalytic residues [active] 391735011152 aspartate-rich region 1; other site 391735011153 active site lid residues [active] 391735011154 aspartate-rich region 2; other site 391735011155 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 391735011156 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 391735011157 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 391735011158 Walker A motif; other site 391735011159 ATP binding site [chemical binding]; other site 391735011160 Walker B motif; other site 391735011161 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 391735011162 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 391735011163 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 391735011164 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 391735011165 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 391735011166 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 391735011167 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 391735011168 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 391735011169 CoA-binding site [chemical binding]; other site 391735011170 ATP-binding [chemical binding]; other site 391735011171 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 391735011172 Domain of unknown function (DUF329); Region: DUF329; cl01144 391735011173 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 391735011174 active site 391735011175 8-oxo-dGMP binding site [chemical binding]; other site 391735011176 nudix motif; other site 391735011177 metal binding site [ion binding]; metal-binding site 391735011178 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 391735011179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735011180 Walker A motif; other site 391735011181 ATP binding site [chemical binding]; other site 391735011182 Walker B motif; other site 391735011183 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 391735011184 heterotetramer interface [polypeptide binding]; other site 391735011185 active site pocket [active] 391735011186 cleavage site 391735011187 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 391735011188 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 391735011189 SEC-C motif; Region: SEC-C; cl12132 391735011190 Peptidase family M23; Region: Peptidase_M23; pfam01551 391735011191 Stringent starvation protein B; Region: SspB; cl01120 391735011192 stringent starvation protein A; Provisional; Region: sspA; PRK09481 391735011193 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 391735011194 C-terminal domain interface [polypeptide binding]; other site 391735011195 putative GSH binding site (G-site) [chemical binding]; other site 391735011196 dimer interface [polypeptide binding]; other site 391735011197 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_C_SspA; cd03186 391735011198 dimer interface [polypeptide binding]; other site 391735011199 N-terminal domain interface [polypeptide binding]; other site 391735011200 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 391735011201 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 391735011202 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284 391735011203 Qi binding site; other site 391735011204 intrachain domain interface; other site 391735011205 interchain domain interface [polypeptide binding]; other site 391735011206 heme bH binding site [chemical binding]; other site 391735011207 heme bL binding site [chemical binding]; other site 391735011208 Qo binding site; other site 391735011209 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cl00193 391735011210 interchain domain interface [polypeptide binding]; other site 391735011211 intrachain domain interface; other site 391735011212 Qi binding site; other site 391735011213 Qo binding site; other site 391735011214 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 391735011215 [2Fe-2S] cluster binding site [ion binding]; other site 391735011216 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 391735011217 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 391735011218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 391735011219 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 391735011220 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 391735011221 RimM N-terminal domain; Region: RimM; pfam01782 391735011222 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 391735011223 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 391735011224 enoyl-CoA hydratase; Provisional; Region: PRK08140 391735011225 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735011226 substrate binding site [chemical binding]; other site 391735011227 oxyanion hole (OAH) forming residues; other site 391735011228 trimer interface [polypeptide binding]; other site 391735011229 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391735011230 CoenzymeA binding site [chemical binding]; other site 391735011231 subunit interaction site [polypeptide binding]; other site 391735011232 PHB binding site; other site 391735011233 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735011234 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 391735011235 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 391735011236 Phenylacetic acid degradation B; Region: PaaB; cl01371 391735011237 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 391735011238 Domain of unknown function DUF59; Region: DUF59; cl00941 391735011239 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 391735011240 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 391735011241 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-...; Region: PA_degradation_oxidoreductase_like; cd06214 391735011242 FAD binding pocket [chemical binding]; other site 391735011243 FAD binding motif [chemical binding]; other site 391735011244 phosphate binding motif [ion binding]; other site 391735011245 beta-alpha-beta structure motif; other site 391735011246 NAD(p) ribose binding residues [chemical binding]; other site 391735011247 NAD binding pocket [chemical binding]; other site 391735011248 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 391735011249 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735011250 catalytic loop [active] 391735011251 iron binding site [ion binding]; other site 391735011252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391735011253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735011254 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735011255 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 391735011256 putative ligand binding site [chemical binding]; other site 391735011257 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 391735011258 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735011259 TM-ABC transporter signature motif; other site 391735011260 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735011261 TM-ABC transporter signature motif; other site 391735011262 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735011263 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735011264 Walker A/P-loop; other site 391735011265 ATP binding site [chemical binding]; other site 391735011266 Q-loop/lid; other site 391735011267 ABC transporter signature motif; other site 391735011268 Walker B; other site 391735011269 D-loop; other site 391735011270 H-loop/switch region; other site 391735011271 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 391735011272 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391735011273 DctM-like transporters; Region: DctM; pfam06808 391735011274 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 391735011275 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 391735011276 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391735011277 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 391735011278 lipoyl attachment site [posttranslational modification]; other site 391735011279 glycine dehydrogenase; Provisional; Region: PRK05367 391735011280 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735011281 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735011282 catalytic residue [active] 391735011283 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 391735011284 tetramer interface [polypeptide binding]; other site 391735011285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735011286 catalytic residue [active] 391735011287 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 391735011288 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 391735011289 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 391735011290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735011291 putative substrate translocation pore; other site 391735011292 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 391735011293 active site 391735011294 catalytic triad [active] 391735011295 oxyanion hole [active] 391735011296 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 391735011297 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 391735011298 active site 391735011299 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 391735011300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735011301 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391735011302 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 391735011303 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011304 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 391735011305 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391735011306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735011308 dimer interface [polypeptide binding]; other site 391735011309 conserved gate region; other site 391735011310 putative PBP binding loops; other site 391735011311 ABC-ATPase subunit interface; other site 391735011312 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391735011313 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 391735011314 Walker A/P-loop; other site 391735011315 ATP binding site [chemical binding]; other site 391735011316 Q-loop/lid; other site 391735011317 ABC transporter signature motif; other site 391735011318 Walker B; other site 391735011319 D-loop; other site 391735011320 H-loop/switch region; other site 391735011321 cyanate hydratase; Validated; Region: PRK02866 391735011322 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 391735011323 oligomer interface [polypeptide binding]; other site 391735011324 active site 391735011325 Predicted ATPase [General function prediction only]; Region: COG1485 391735011326 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 391735011327 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735011328 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391735011329 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 391735011330 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391735011331 E3 interaction surface; other site 391735011332 lipoyl attachment site [posttranslational modification]; other site 391735011333 e3 binding domain; Region: E3_binding; pfam02817 391735011334 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 391735011335 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 391735011336 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 391735011337 TPP-binding site [chemical binding]; other site 391735011338 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 391735011339 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 391735011340 Domain of unknown function DUF20; Region: UPF0118; cl00465 391735011341 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 391735011342 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735011343 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 391735011344 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 391735011345 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 391735011346 classical (c) SDRs; Region: SDR_c; cd05233 391735011347 NAD(P) binding site [chemical binding]; other site 391735011348 active site 391735011349 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 391735011350 active site 391735011351 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735011352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735011353 Bacterial transcriptional regulator; Region: IclR; pfam01614 391735011354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735011355 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735011357 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735011359 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011360 hypothetical protein; Validated; Region: PRK06201 391735011361 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 391735011362 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391735011363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735011364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735011365 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391735011366 Walker A motif; other site 391735011367 ATP binding site [chemical binding]; other site 391735011368 Walker B motif; other site 391735011369 arginine finger; other site 391735011370 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011371 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 391735011372 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl04869 391735011373 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 391735011374 4Fe-4S binding domain; Region: Fer4; cl02805 391735011375 DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 391735011376 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 391735011377 molybdopterin cofactor binding site; other site 391735011378 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 391735011379 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD...; Region: MopB_CT_2; cd02783 391735011380 putative molybdopterin cofactor binding site; other site 391735011381 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 391735011382 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 391735011383 putative dimerization interface [polypeptide binding]; other site 391735011384 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 391735011385 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 391735011386 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 391735011387 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391735011388 PYR/PP interface [polypeptide binding]; other site 391735011389 dimer interface [polypeptide binding]; other site 391735011390 TPP binding site [chemical binding]; other site 391735011391 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391735011392 TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the desulfonation of 2-sulfoacetaldehyde into sulfite and acetyl...; Region: TPP_Xsc_like; cd02013 391735011393 TPP-binding site; other site 391735011394 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735011395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735011396 Bacterial transcriptional regulator; Region: IclR; pfam01614 391735011397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735011398 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011399 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011400 DUF35 OB-fold domain; Region: DUF35; pfam01796 391735011401 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391735011402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735011403 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735011404 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735011405 Walker A/P-loop; other site 391735011406 ATP binding site [chemical binding]; other site 391735011407 Q-loop/lid; other site 391735011408 ABC transporter signature motif; other site 391735011409 Walker B; other site 391735011410 D-loop; other site 391735011411 H-loop/switch region; other site 391735011412 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735011413 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735011414 Walker A/P-loop; other site 391735011415 ATP binding site [chemical binding]; other site 391735011416 Q-loop/lid; other site 391735011417 ABC transporter signature motif; other site 391735011418 Walker B; other site 391735011419 D-loop; other site 391735011420 H-loop/switch region; other site 391735011421 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735011422 TM-ABC transporter signature motif; other site 391735011423 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735011424 TM-ABC transporter signature motif; other site 391735011425 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735011426 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 391735011427 ligand binding site [chemical binding]; other site 391735011428 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 391735011429 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 391735011430 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391735011431 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 391735011432 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 391735011433 Walker A motif; other site 391735011434 ATP binding site [chemical binding]; other site 391735011435 Walker B motif; other site 391735011436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735011437 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 391735011438 Predicted esterase [General function prediction only]; Region: COG0627 391735011439 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735011440 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 391735011441 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 391735011442 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 391735011443 substrate binding site [chemical binding]; other site 391735011444 catalytic Zn binding site [ion binding]; other site 391735011445 NAD binding site [chemical binding]; other site 391735011446 structural Zn binding site [ion binding]; other site 391735011447 dimer interface [polypeptide binding]; other site 391735011448 Coenzyme A transferase; Region: CoA_trans; cl00773 391735011449 Coenzyme A transferase; Region: CoA_trans; cl00773 391735011450 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 391735011451 metal ion-dependent adhesion site (MIDAS); other site 391735011452 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 391735011453 metal ion-dependent adhesion site (MIDAS); other site 391735011454 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 391735011455 MoxR-like ATPases [General function prediction only]; Region: COG0714 391735011456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735011457 Walker A motif; other site 391735011458 ATP binding site [chemical binding]; other site 391735011459 Walker B motif; other site 391735011460 arginine finger; other site 391735011461 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391735011462 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 391735011463 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 391735011464 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 391735011465 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 391735011466 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 391735011467 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735011468 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 391735011469 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735011470 active site 391735011471 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735011472 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391735011473 tetramerization interface [polypeptide binding]; other site 391735011474 NAD(P) binding site [chemical binding]; other site 391735011475 catalytic residues [active] 391735011476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735011477 dimer interface [polypeptide binding]; other site 391735011478 conserved gate region; other site 391735011479 putative PBP binding loops; other site 391735011480 ABC-ATPase subunit interface; other site 391735011481 EBNA-3B; Provisional; Region: PHA03378 391735011482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735011483 dimer interface [polypeptide binding]; other site 391735011484 conserved gate region; other site 391735011485 putative PBP binding loops; other site 391735011486 ABC-ATPase subunit interface; other site 391735011487 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391735011488 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011489 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391735011490 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 391735011491 Walker A/P-loop; other site 391735011492 ATP binding site [chemical binding]; other site 391735011493 Q-loop/lid; other site 391735011494 ABC transporter signature motif; other site 391735011495 Walker B; other site 391735011496 D-loop; other site 391735011497 H-loop/switch region; other site 391735011498 TOBE domain; Region: TOBE_2; cl01440 391735011499 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 391735011500 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735011501 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735011502 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 391735011503 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391735011504 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391735011505 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391735011506 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 391735011507 active site 391735011508 dimer interface [polypeptide binding]; other site 391735011509 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391735011510 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011511 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 391735011512 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 391735011513 putative active site [active] 391735011514 putative FMN binding site [chemical binding]; other site 391735011515 putative substrate binding site [chemical binding]; other site 391735011516 putative catalytic residue [active] 391735011517 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 391735011518 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 391735011519 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 391735011520 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 391735011521 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391735011522 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 391735011523 [2Fe-2S] cluster binding site [ion binding]; other site 391735011524 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 391735011525 putative alpha subunit interface [polypeptide binding]; other site 391735011526 putative active site [active] 391735011527 putative substrate binding site [chemical binding]; other site 391735011528 Fe binding site [ion binding]; other site 391735011529 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391735011530 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 391735011531 FAD binding pocket [chemical binding]; other site 391735011532 FAD binding motif [chemical binding]; other site 391735011533 phosphate binding motif [ion binding]; other site 391735011534 beta-alpha-beta structure motif; other site 391735011535 NAD binding pocket [chemical binding]; other site 391735011536 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735011537 catalytic loop [active] 391735011538 iron binding site [ion binding]; other site 391735011539 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 391735011540 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 391735011541 Walker A/P-loop; other site 391735011542 ATP binding site [chemical binding]; other site 391735011543 Q-loop/lid; other site 391735011544 ABC transporter signature motif; other site 391735011545 Walker B; other site 391735011546 D-loop; other site 391735011547 H-loop/switch region; other site 391735011548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735011549 dimer interface [polypeptide binding]; other site 391735011550 conserved gate region; other site 391735011551 putative PBP binding loops; other site 391735011552 ABC-ATPase subunit interface; other site 391735011553 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391735011554 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391735011555 conserved cys residue [active] 391735011556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391735011557 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391735011558 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735011559 DNA-binding site [nucleotide binding]; DNA binding site 391735011560 FCD domain; Region: FCD; cl11656 391735011561 Transposase domain (DUF772); Region: DUF772; cl12084 391735011562 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 391735011563 PhoH-like protein; Region: PhoH; cl12134 391735011564 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 391735011565 RuvA N terminal domain; Region: RuvA_N; pfam01330 391735011566 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 391735011567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735011568 Walker A motif; other site 391735011569 ATP binding site [chemical binding]; other site 391735011570 Walker B motif; other site 391735011571 arginine finger; other site 391735011572 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 391735011573 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 391735011574 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 391735011575 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735011576 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735011577 Walker A/P-loop; other site 391735011578 ATP binding site [chemical binding]; other site 391735011579 Q-loop/lid; other site 391735011580 ABC transporter signature motif; other site 391735011581 Walker B; other site 391735011582 D-loop; other site 391735011583 H-loop/switch region; other site 391735011584 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735011585 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735011586 Walker A/P-loop; other site 391735011587 ATP binding site [chemical binding]; other site 391735011588 Q-loop/lid; other site 391735011589 ABC transporter signature motif; other site 391735011590 Walker B; other site 391735011591 D-loop; other site 391735011592 H-loop/switch region; other site 391735011593 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735011594 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 391735011595 putative ligand binding site [chemical binding]; other site 391735011596 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735011597 TM-ABC transporter signature motif; other site 391735011598 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735011599 TM-ABC transporter signature motif; other site 391735011600 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 391735011601 substrate binding site [chemical binding]; other site 391735011602 hinge regions; other site 391735011603 ADP binding site [chemical binding]; other site 391735011604 catalytic site [active] 391735011605 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 391735011606 AzlC protein; Region: AzlC; cl00570 391735011607 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 391735011608 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 391735011609 putative active site [active] 391735011610 substrate binding site [chemical binding]; other site 391735011611 putative cosubstrate binding site; other site 391735011612 catalytic site [active] 391735011613 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 391735011614 substrate binding site [chemical binding]; other site 391735011615 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 391735011616 active site 391735011617 catalytic residues [active] 391735011618 metal binding site [ion binding]; metal-binding site 391735011619 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 391735011620 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 391735011621 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 391735011622 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 391735011623 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 391735011624 Protein export membrane protein; Region: SecD_SecF; cl14618 391735011625 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 391735011626 Protein export membrane protein; Region: SecD_SecF; cl14618 391735011627 Preprotein translocase subunit; Region: YajC; cl00806 391735011628 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 391735011629 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 391735011630 dimer interface [polypeptide binding]; other site 391735011631 PYR/PP interface [polypeptide binding]; other site 391735011632 TPP binding site [chemical binding]; other site 391735011633 substrate binding site [chemical binding]; other site 391735011634 TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the...; Region: TPP_IOR_alpha; cd02008 391735011635 TPP-binding site; other site 391735011636 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 391735011637 Bacterial protein of unknown function (DUF894); Region: DUF894; pfam05977 391735011638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735011639 putative substrate translocation pore; other site 391735011640 enoyl-CoA hydratase; Provisional; Region: PRK08259 391735011641 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735011642 substrate binding site [chemical binding]; other site 391735011643 oxyanion hole (OAH) forming residues; other site 391735011644 trimer interface [polypeptide binding]; other site 391735011645 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735011646 TM-ABC transporter signature motif; other site 391735011647 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735011648 TM-ABC transporter signature motif; other site 391735011649 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735011650 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735011651 Walker A/P-loop; other site 391735011652 ATP binding site [chemical binding]; other site 391735011653 Q-loop/lid; other site 391735011654 ABC transporter signature motif; other site 391735011655 Walker B; other site 391735011656 D-loop; other site 391735011657 H-loop/switch region; other site 391735011658 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735011659 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735011660 Walker A/P-loop; other site 391735011661 ATP binding site [chemical binding]; other site 391735011662 Q-loop/lid; other site 391735011663 ABC transporter signature motif; other site 391735011664 Walker B; other site 391735011665 D-loop; other site 391735011666 H-loop/switch region; other site 391735011667 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 391735011668 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735011669 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735011670 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735011671 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391735011672 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391735011673 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735011674 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735011675 active site 391735011676 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391735011677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735011678 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735011679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735011680 NAD(P) binding site [chemical binding]; other site 391735011681 active site 391735011682 2-ketocyclohexanecarboxyl-CoA hydrolase; Region: badI; TIGR03210 391735011683 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735011684 substrate binding site [chemical binding]; other site 391735011685 oxyanion hole (OAH) forming residues; other site 391735011686 trimer interface [polypeptide binding]; other site 391735011687 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 391735011688 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 391735011689 active site 391735011690 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 391735011691 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735011692 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735011693 TM-ABC transporter signature motif; other site 391735011694 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735011695 TM-ABC transporter signature motif; other site 391735011696 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735011697 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735011698 Walker A/P-loop; other site 391735011699 ATP binding site [chemical binding]; other site 391735011700 Q-loop/lid; other site 391735011701 ABC transporter signature motif; other site 391735011702 Walker B; other site 391735011703 D-loop; other site 391735011704 H-loop/switch region; other site 391735011705 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735011706 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735011707 Walker A/P-loop; other site 391735011708 ATP binding site [chemical binding]; other site 391735011709 Q-loop/lid; other site 391735011710 ABC transporter signature motif; other site 391735011711 Walker B; other site 391735011712 D-loop; other site 391735011713 H-loop/switch region; other site 391735011714 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735011715 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 391735011716 putative ligand binding site [chemical binding]; other site 391735011717 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 391735011718 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 391735011719 dimer interface [polypeptide binding]; other site 391735011720 active site 391735011721 catalytic residue [active] 391735011722 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735011723 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 391735011724 putative NAD(P) binding site [chemical binding]; other site 391735011725 putative active site [active] 391735011726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735011727 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011728 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 391735011729 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391735011730 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735011731 Walker A/P-loop; other site 391735011732 ATP binding site [chemical binding]; other site 391735011733 Q-loop/lid; other site 391735011734 ABC transporter signature motif; other site 391735011735 Walker B; other site 391735011736 D-loop; other site 391735011737 H-loop/switch region; other site 391735011738 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735011739 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735011740 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735011741 Walker A/P-loop; other site 391735011742 ATP binding site [chemical binding]; other site 391735011743 Q-loop/lid; other site 391735011744 ABC transporter signature motif; other site 391735011745 Walker B; other site 391735011746 D-loop; other site 391735011747 H-loop/switch region; other site 391735011748 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735011749 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 391735011750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735011751 dimer interface [polypeptide binding]; other site 391735011752 conserved gate region; other site 391735011753 putative PBP binding loops; other site 391735011754 ABC-ATPase subunit interface; other site 391735011755 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735011756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735011757 dimer interface [polypeptide binding]; other site 391735011758 conserved gate region; other site 391735011759 putative PBP binding loops; other site 391735011760 ABC-ATPase subunit interface; other site 391735011761 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 391735011762 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735011763 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391735011764 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 391735011765 putative active site [active] 391735011766 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735011767 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 391735011768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735011769 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735011770 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391735011771 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735011772 DNA-binding site [nucleotide binding]; DNA binding site 391735011773 FCD domain; Region: FCD; cl11656 391735011774 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 391735011775 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 391735011776 cystathionine beta-lyase; Provisional; Region: PRK09028 391735011777 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735011778 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735011779 catalytic residue [active] 391735011780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735011781 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011782 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391735011783 active site residue [active] 391735011784 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative...; Region: 4RHOD_Repeat_2; cd01533 391735011785 active site residue [active] 391735011786 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 391735011787 active site residue [active] 391735011788 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391735011789 active site residue [active] 391735011790 Cysteine dioxygenase type I; Region: CDO_I; cl02350 391735011791 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735011792 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 391735011793 putative dimerization interface [polypeptide binding]; other site 391735011794 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735011795 NIMA-related protein kinase; Provisional; Region: PTZ00266 391735011796 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735011797 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 391735011798 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 391735011799 oligomeric interface; other site 391735011800 putative active site [active] 391735011801 homodimer interface [polypeptide binding]; other site 391735011802 allantoate amidohydrolase; Reviewed; Region: PRK12893 391735011803 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 391735011804 active site 391735011805 metal binding site [ion binding]; metal-binding site 391735011806 dimer interface [polypeptide binding]; other site 391735011807 phenylhydantoinase; Validated; Region: PRK08323 391735011808 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like...; Region: D-HYD; cd01314 391735011809 tetramer interface [polypeptide binding]; other site 391735011810 active site 391735011811 Sodium:solute symporter family; Region: SSF; cl00456 391735011812 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 391735011813 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 391735011814 homodimer interface [polypeptide binding]; other site 391735011815 active site 391735011816 FMN binding site [chemical binding]; other site 391735011817 substrate binding site [chemical binding]; other site 391735011818 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 391735011819 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 391735011820 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 391735011821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735011822 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 391735011823 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 391735011824 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 391735011825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 391735011826 FeS/SAM binding site; other site 391735011827 HemN C-terminal region; Region: HemN_C; pfam06969 391735011828 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 391735011829 active site 391735011830 dimerization interface [polypeptide binding]; other site 391735011831 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 391735011832 Protein phosphatase 2C; Region: PP2C; pfam00481 391735011833 Active site [active] 391735011834 Protein kinase domain; Region: Pkinase; pfam00069 391735011835 Catalytic domain of Protein Kinases; Region: PKc; cd00180 391735011836 active site 391735011837 ATP binding site [chemical binding]; other site 391735011838 substrate binding site [chemical binding]; other site 391735011839 activation loop (A-loop); other site 391735011840 hypothetical protein; Provisional; Region: PRK11820 391735011841 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 391735011842 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 391735011843 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 391735011844 Phage integrase family; Region: Phage_integrase; pfam00589 391735011845 active site 391735011846 Int/Topo IB signature motif; other site 391735011847 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391735011848 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391735011849 Fic family protein [Function unknown]; Region: COG3177 391735011850 Fic/DOC family; Region: Fic; cl00960 391735011851 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 391735011852 Predicted ATPase [General function prediction only]; Region: COG4637 391735011853 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735011854 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 391735011855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735011856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735011857 Uncharacterized conserved protein [Function unknown]; Region: COG4938 391735011858 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735011859 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735011860 ABC transporter signature motif; other site 391735011861 Walker B; other site 391735011862 D-loop; other site 391735011863 H-loop/switch region; other site 391735011864 UvrD/REP helicase; Region: UvrD-helicase; cl14126 391735011865 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 391735011866 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391735011867 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391735011868 DNA binding site [nucleotide binding] 391735011869 active site 391735011870 Int/Topo IB signature motif; other site 391735011871 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735011872 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735011873 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735011874 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 391735011875 active site 391735011876 substrate binding site [chemical binding]; other site 391735011877 catalytic site [active] 391735011878 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both synthetic (...; Region: POLBc; cl10023 391735011879 active site 391735011880 DNA polymerase II; Reviewed; Region: PRK05762 391735011881 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 391735011882 catalytic site [active] 391735011883 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170 391735011884 elongation factor G; Reviewed; Region: PRK12740 391735011885 G1 box; other site 391735011886 putative GEF interaction site [polypeptide binding]; other site 391735011887 GTP/Mg2+ binding site [chemical binding]; other site 391735011888 Switch I region; other site 391735011889 G2 box; other site 391735011890 G3 box; other site 391735011891 Switch II region; other site 391735011892 G4 box; other site 391735011893 G5 box; other site 391735011894 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 391735011895 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 391735011896 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 391735011897 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 391735011898 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735011899 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735011900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735011901 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011902 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735011903 enoyl-CoA hydratase; Provisional; Region: PRK09245 391735011904 substrate binding site [chemical binding]; other site 391735011905 oxyanion hole (OAH) forming residues; other site 391735011906 trimer interface [polypeptide binding]; other site 391735011907 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735011908 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735011909 active site 391735011910 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 391735011911 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391735011912 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735011913 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 391735011914 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 391735011915 carboxyltransferase (CT) interaction site; other site 391735011916 biotinylation site [posttranslational modification]; other site 391735011917 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 391735011918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735011919 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011920 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 391735011921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011922 dimerization interface [polypeptide binding]; other site 391735011923 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735011924 enoyl-CoA hydratase; Provisional; Region: PRK05995 391735011925 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735011926 substrate binding site [chemical binding]; other site 391735011927 oxyanion hole (OAH) forming residues; other site 391735011928 trimer interface [polypeptide binding]; other site 391735011929 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 391735011930 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391735011931 dimer interface [polypeptide binding]; other site 391735011932 active site 391735011933 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 391735011934 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 391735011935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735011936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011937 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 391735011938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735011939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011940 dimerization interface [polypeptide binding]; other site 391735011941 ornithine cyclodeaminase; Validated; Region: PRK06141 391735011942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735011943 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 391735011944 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate...; Region: MopB_Acetylene-hydratase; cd02759 391735011945 putative [Fe4-S4] binding site [ion binding]; other site 391735011946 putative molybdopterin cofactor binding site [chemical binding]; other site 391735011947 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 391735011948 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate...; Region: MopB_CT_Acetylene-hydratase; cd02781 391735011949 putative molybdopterin cofactor binding site; other site 391735011950 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391735011951 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 391735011952 FAD binding pocket [chemical binding]; other site 391735011953 FAD binding motif [chemical binding]; other site 391735011954 phosphate binding motif [ion binding]; other site 391735011955 beta-alpha-beta structure motif; other site 391735011956 NAD binding pocket [chemical binding]; other site 391735011957 Heme binding pocket [chemical binding]; other site 391735011958 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735011959 catalytic loop [active] 391735011960 iron binding site [ion binding]; other site 391735011961 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 391735011962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735011963 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735011964 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735011965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391735011966 Helix-turn-helix domain; Region: HTH_18; pfam12833 391735011967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735011968 DNA-binding site [nucleotide binding]; DNA binding site 391735011969 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391735011970 FCD domain; Region: FCD; cl11656 391735011971 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735011972 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391735011973 Predicted amidohydrolase [General function prediction only]; Region: COG0388 391735011974 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 391735011975 putative active site [active] 391735011976 catalytic triad [active] 391735011977 putative dimer interface [polypeptide binding]; other site 391735011978 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735011979 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735011980 Walker A/P-loop; other site 391735011981 ATP binding site [chemical binding]; other site 391735011982 Q-loop/lid; other site 391735011983 ABC transporter signature motif; other site 391735011984 Walker B; other site 391735011985 D-loop; other site 391735011986 H-loop/switch region; other site 391735011987 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735011988 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735011989 Walker A/P-loop; other site 391735011990 ATP binding site [chemical binding]; other site 391735011991 Q-loop/lid; other site 391735011992 ABC transporter signature motif; other site 391735011993 Walker B; other site 391735011994 D-loop; other site 391735011995 H-loop/switch region; other site 391735011996 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735011997 TM-ABC transporter signature motif; other site 391735011998 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735011999 TM-ABC transporter signature motif; other site 391735012000 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735012001 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 391735012002 putative ligand binding site [chemical binding]; other site 391735012003 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391735012004 PYR/PP interface [polypeptide binding]; other site 391735012005 dimer interface [polypeptide binding]; other site 391735012006 TPP binding site [chemical binding]; other site 391735012007 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391735012008 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 391735012009 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391735012010 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 391735012011 Cupin domain; Region: Cupin_2; cl09118 391735012012 Cupin domain; Region: Cupin_2; cl09118 391735012013 Flavin Reductases; Region: FlaRed; cl00801 391735012014 6-phosphofructokinase; Region: PLN02564 391735012015 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 391735012016 catalytic site [active] 391735012017 G-X2-G-X-G-K; other site 391735012018 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 391735012019 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 391735012020 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 391735012021 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 391735012022 synthetase active site [active] 391735012023 NTP binding site [chemical binding]; other site 391735012024 metal binding site [ion binding]; metal-binding site 391735012025 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 391735012026 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 391735012027 EVE domain; Region: EVE; cl00728 391735012028 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 391735012029 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 391735012030 active site 391735012031 dimer interface [polypeptide binding]; other site 391735012032 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 391735012033 dimer interface [polypeptide binding]; other site 391735012034 active site 391735012035 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 391735012036 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 391735012037 dimerization interface [polypeptide binding]; other site 391735012038 putative active cleft [active] 391735012039 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 391735012040 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 391735012041 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 391735012042 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 391735012043 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 391735012044 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 391735012045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735012046 ATP binding site [chemical binding]; other site 391735012047 Mg2+ binding site [ion binding]; other site 391735012048 G-X-G motif; other site 391735012049 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 391735012050 ATP binding site [chemical binding]; other site 391735012051 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 391735012052 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 391735012053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735012054 putative substrate translocation pore; other site 391735012055 IPP transferase; Region: IPPT; cl00403 391735012056 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 391735012057 putative active site [active] 391735012058 putative metal binding site [ion binding]; other site 391735012059 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 391735012060 substrate binding site [chemical binding]; other site 391735012061 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 391735012062 substrate binding site [chemical binding]; other site 391735012063 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 391735012064 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391735012065 active site 391735012066 HIGH motif; other site 391735012067 nucleotide binding site [chemical binding]; other site 391735012068 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391735012069 active site 391735012070 KMSKS motif; other site 391735012071 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 391735012072 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735012073 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 391735012074 Domain of unknown function DUF28; Region: DUF28; cl00361 391735012075 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 391735012076 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 391735012077 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735012078 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 391735012079 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 391735012080 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012081 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012082 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012083 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012084 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012085 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012086 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012087 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 391735012088 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735012089 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735012090 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 391735012091 dimer interface [polypeptide binding]; other site 391735012092 glycine-pyridoxal phosphate binding site [chemical binding]; other site 391735012093 active site 391735012094 folate binding site [chemical binding]; other site 391735012095 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 391735012096 ATP cone domain; Region: ATP-cone; pfam03477 391735012097 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 391735012098 active site 391735012099 dimerization interface [polypeptide binding]; other site 391735012100 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 391735012101 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 391735012102 Cupin domain; Region: Cupin_2; cl09118 391735012103 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391735012104 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735012105 Walker A/P-loop; other site 391735012106 ATP binding site [chemical binding]; other site 391735012107 Q-loop/lid; other site 391735012108 ABC transporter signature motif; other site 391735012109 Walker B; other site 391735012110 D-loop; other site 391735012111 H-loop/switch region; other site 391735012112 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735012113 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735012114 Walker A/P-loop; other site 391735012115 ATP binding site [chemical binding]; other site 391735012116 Q-loop/lid; other site 391735012117 ABC transporter signature motif; other site 391735012118 Walker B; other site 391735012119 D-loop; other site 391735012120 H-loop/switch region; other site 391735012121 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735012122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735012123 dimer interface [polypeptide binding]; other site 391735012124 conserved gate region; other site 391735012125 putative PBP binding loops; other site 391735012126 ABC-ATPase subunit interface; other site 391735012127 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735012128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735012129 dimer interface [polypeptide binding]; other site 391735012130 conserved gate region; other site 391735012131 putative PBP binding loops; other site 391735012132 ABC-ATPase subunit interface; other site 391735012133 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 391735012134 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735012135 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391735012136 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735012137 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391735012138 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 391735012139 metal binding site [ion binding]; metal-binding site 391735012140 putative dimer interface [polypeptide binding]; other site 391735012141 serine O-acetyltransferase; Region: cysE; TIGR01172 391735012142 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 391735012143 trimer interface [polypeptide binding]; other site 391735012144 active site 391735012145 substrate binding site [chemical binding]; other site 391735012146 CoA binding site [chemical binding]; other site 391735012147 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 391735012148 MPT binding site; other site 391735012149 trimer interface [polypeptide binding]; other site 391735012150 Protein of unknown function (DUF615); Region: DUF615; cl01147 391735012151 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 391735012152 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 391735012153 galactarate dehydratase; Region: galactar-dH20; TIGR03248 391735012154 SAF domain; Region: SAF; cl00555 391735012155 SAF domain; Region: SAF; cl00555 391735012156 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735012157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 391735012158 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 391735012159 DUF35 OB-fold domain; Region: DUF35; pfam01796 391735012160 lipid-transfer protein; Provisional; Region: PRK07855 391735012161 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 391735012162 active site 391735012163 enoyl-CoA hydratase; Provisional; Region: PRK06494 391735012164 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735012165 substrate binding site [chemical binding]; other site 391735012166 oxyanion hole (OAH) forming residues; other site 391735012167 trimer interface [polypeptide binding]; other site 391735012168 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 391735012169 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735012170 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735012171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735012172 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735012173 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 391735012174 Integrase core domain; Region: rve; cl01316 391735012175 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735012176 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391735012177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735012178 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735012179 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 391735012180 putative catalytic cysteine [active] 391735012181 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391735012182 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735012183 choline dehydrogenase; Validated; Region: PRK02106 391735012184 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735012185 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391735012186 metabolite-proton symporter; Region: 2A0106; TIGR00883 391735012187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735012188 putative substrate translocation pore; other site 391735012189 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391735012190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735012191 dimer interface [polypeptide binding]; other site 391735012192 conserved gate region; other site 391735012193 putative PBP binding loops; other site 391735012194 ABC-ATPase subunit interface; other site 391735012195 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 391735012196 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 391735012197 Walker A/P-loop; other site 391735012198 ATP binding site [chemical binding]; other site 391735012199 Q-loop/lid; other site 391735012200 ABC transporter signature motif; other site 391735012201 Walker B; other site 391735012202 D-loop; other site 391735012203 H-loop/switch region; other site 391735012204 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 391735012205 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735012206 substrate binding pocket [chemical binding]; other site 391735012207 membrane-bound complex binding site; other site 391735012208 hinge residues; other site 391735012209 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391735012210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735012211 DNA-binding site [nucleotide binding]; DNA binding site 391735012212 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391735012213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735012214 homodimer interface [polypeptide binding]; other site 391735012215 catalytic residue [active] 391735012216 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735012217 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391735012218 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391735012219 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 391735012220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735012221 dimer interface [polypeptide binding]; other site 391735012222 conserved gate region; other site 391735012223 putative PBP binding loops; other site 391735012224 ABC-ATPase subunit interface; other site 391735012225 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391735012226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735012227 dimer interface [polypeptide binding]; other site 391735012228 conserved gate region; other site 391735012229 putative PBP binding loops; other site 391735012230 ABC-ATPase subunit interface; other site 391735012231 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735012232 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735012233 Walker A/P-loop; other site 391735012234 ATP binding site [chemical binding]; other site 391735012235 Q-loop/lid; other site 391735012236 ABC transporter signature motif; other site 391735012237 Walker B; other site 391735012238 D-loop; other site 391735012239 H-loop/switch region; other site 391735012240 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735012241 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 391735012242 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735012243 Walker A/P-loop; other site 391735012244 ATP binding site [chemical binding]; other site 391735012245 Q-loop/lid; other site 391735012246 ABC transporter signature motif; other site 391735012247 Walker B; other site 391735012248 D-loop; other site 391735012249 H-loop/switch region; other site 391735012250 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735012251 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 391735012252 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 391735012253 active site 391735012254 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 391735012255 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 391735012256 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735012257 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735012258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735012259 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391735012260 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391735012261 DNA binding site [nucleotide binding] 391735012262 domain linker motif; other site 391735012263 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 391735012264 putative dimerization interface [polypeptide binding]; other site 391735012265 putative ligand binding site [chemical binding]; other site 391735012266 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391735012267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391735012268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391735012269 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 391735012270 dimer interface [polypeptide binding]; other site 391735012271 catalytic triad [active] 391735012272 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 391735012273 active site 391735012274 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735012275 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735012276 active site 391735012277 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 391735012278 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 391735012279 putative active site [active] 391735012280 putative substrate binding site [chemical binding]; other site 391735012281 ATP binding site [chemical binding]; other site 391735012282 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391735012283 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391735012284 ligand binding site [chemical binding]; other site 391735012285 flexible hinge region; other site 391735012286 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 391735012287 thiamine phosphate binding site [chemical binding]; other site 391735012288 active site 391735012289 pyrophosphate binding site [ion binding]; other site 391735012290 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 391735012291 ThiS interaction site; other site 391735012292 putative active site [active] 391735012293 tetramer interface [polypeptide binding]; other site 391735012294 Ubiquitin-like proteins; Region: UBQ; cl00155 391735012295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735012296 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 391735012297 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 391735012298 dimer interface [polypeptide binding]; other site 391735012299 substrate binding site [chemical binding]; other site 391735012300 ATP binding site [chemical binding]; other site 391735012301 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 391735012302 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735012303 Ferredoxin [Energy production and conversion]; Region: COG1146 391735012304 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 391735012305 HipA N-terminal domain; Region: couple_hipA; TIGR03071 391735012306 HipA-like N-terminal domain; Region: HipA_N; pfam07805 391735012307 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391735012308 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735012309 DNA-binding site [nucleotide binding]; DNA binding site 391735012310 FCD domain; Region: FCD; cl11656 391735012311 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 391735012312 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 391735012313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735012314 dimer interface [polypeptide binding]; other site 391735012315 conserved gate region; other site 391735012316 putative PBP binding loops; other site 391735012317 ABC-ATPase subunit interface; other site 391735012318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735012319 dimer interface [polypeptide binding]; other site 391735012320 conserved gate region; other site 391735012321 putative PBP binding loops; other site 391735012322 ABC-ATPase subunit interface; other site 391735012323 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391735012324 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735012325 Walker A/P-loop; other site 391735012326 ATP binding site [chemical binding]; other site 391735012327 Q-loop/lid; other site 391735012328 ABC transporter signature motif; other site 391735012329 Walker B; other site 391735012330 D-loop; other site 391735012331 H-loop/switch region; other site 391735012332 TOBE domain; Region: TOBE_2; cl01440 391735012333 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391735012334 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735012335 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735012336 TM-ABC transporter signature motif; other site 391735012337 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 391735012338 ligand binding site [chemical binding]; other site 391735012339 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 391735012340 ligand binding site [chemical binding]; other site 391735012341 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735012342 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735012343 Walker A/P-loop; other site 391735012344 ATP binding site [chemical binding]; other site 391735012345 Q-loop/lid; other site 391735012346 ABC transporter signature motif; other site 391735012347 Walker B; other site 391735012348 D-loop; other site 391735012349 H-loop/switch region; other site 391735012350 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735012351 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391735012352 TM-ABC transporter signature motif; other site 391735012353 sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034 391735012354 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 391735012355 G1 box; other site 391735012356 GTP/Mg2+ binding site [chemical binding]; other site 391735012357 G2 box; other site 391735012358 Switch I region; other site 391735012359 G3 box; other site 391735012360 Switch II region; other site 391735012361 G4 box; other site 391735012362 G5 box; other site 391735012363 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 391735012364 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 391735012365 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 391735012366 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 391735012367 Active Sites [active] 391735012368 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 391735012369 Active Sites [active] 391735012370 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 391735012371 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 391735012372 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391735012373 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391735012374 LysE type translocator; Region: LysE; cl00565 391735012375 alanine racemase; Reviewed; Region: dadX; PRK03646 391735012376 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 391735012377 active site 391735012378 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391735012379 substrate binding site [chemical binding]; other site 391735012380 catalytic residues [active] 391735012381 dimer interface [polypeptide binding]; other site 391735012382 lysophospholipid transporter LplT; Provisional; Region: PRK11195 391735012383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735012384 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 391735012385 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012386 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012387 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 391735012388 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 391735012389 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 391735012390 putative metal dependent hydrolase; Provisional; Region: PRK11598 391735012391 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 391735012392 Sulfatase; Region: Sulfatase; cl10460 391735012393 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 391735012394 dimer interface [polypeptide binding]; other site 391735012395 Citrate synthase; Region: Citrate_synt; pfam00285 391735012396 active site 391735012397 citrylCoA binding site [chemical binding]; other site 391735012398 NADH binding [chemical binding]; other site 391735012399 cationic pore residues; other site 391735012400 oxalacetate/citrate binding site [chemical binding]; other site 391735012401 coenzyme A binding site [chemical binding]; other site 391735012402 catalytic triad [active] 391735012403 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 391735012404 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 391735012405 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735012406 domain; Region: Succ_DH_flav_C; pfam02910 391735012407 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 391735012408 SdhC subunit interface [polypeptide binding]; other site 391735012409 proximal heme binding site [chemical binding]; other site 391735012410 cardiolipin binding site; other site 391735012411 Iron-sulfur protein interface; other site 391735012412 proximal quinone binding site [chemical binding]; other site 391735012413 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 391735012414 Iron-sulfur protein interface; other site 391735012415 proximal quinone binding site [chemical binding]; other site 391735012416 SdhD (CybS) interface [polypeptide binding]; other site 391735012417 proximal heme binding site [chemical binding]; other site 391735012418 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391735012419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735012420 DNA-binding site [nucleotide binding]; DNA binding site 391735012421 UTRA domain; Region: UTRA; cl06649 391735012422 malate dehydrogenase; Provisional; Region: PRK05442 391735012423 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 391735012424 NAD(P) binding site [chemical binding]; other site 391735012425 dimer interface [polypeptide binding]; other site 391735012426 malate binding site [chemical binding]; other site 391735012427 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 391735012428 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change...; Region: AcnB_Swivel; cd01576 391735012429 substrate binding site [chemical binding]; other site 391735012430 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 391735012431 substrate binding site [chemical binding]; other site 391735012432 ligand binding site [chemical binding]; other site 391735012433 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 391735012434 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 391735012435 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391735012436 ATP binding site [chemical binding]; other site 391735012437 putative Mg++ binding site [ion binding]; other site 391735012438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391735012439 nucleotide binding region [chemical binding]; other site 391735012440 ATP-binding site [chemical binding]; other site 391735012441 TRCF domain; Region: TRCF; pfam03461 391735012442 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 391735012443 substrate binding site [chemical binding]; other site 391735012444 dimer interface [polypeptide binding]; other site 391735012445 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 391735012446 homotrimer interaction site [polypeptide binding]; other site 391735012447 zinc binding site [ion binding]; other site 391735012448 CDP-binding sites; other site 391735012449 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 391735012450 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 391735012451 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 391735012452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735012453 ATP binding site [chemical binding]; other site 391735012454 Mg2+ binding site [ion binding]; other site 391735012455 G-X-G motif; other site 391735012456 osmolarity response regulator; Provisional; Region: ompR; PRK09468 391735012457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735012458 active site 391735012459 phosphorylation site [posttranslational modification] 391735012460 intermolecular recognition site; other site 391735012461 dimerization interface [polypeptide binding]; other site 391735012462 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 391735012463 DNA binding site [nucleotide binding] 391735012464 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 391735012465 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 391735012466 NAD binding site [chemical binding]; other site 391735012467 homotetramer interface [polypeptide binding]; other site 391735012468 homodimer interface [polypeptide binding]; other site 391735012469 substrate binding site [chemical binding]; other site 391735012470 active site 391735012471 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391735012472 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 391735012473 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 391735012474 synthetase active site [active] 391735012475 NTP binding site [chemical binding]; other site 391735012476 metal binding site [ion binding]; metal-binding site 391735012477 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 391735012478 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 391735012479 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391735012480 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 391735012481 putative active site [active] 391735012482 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 391735012483 substrate binding pocket [chemical binding]; other site 391735012484 substrate-Mg2+ binding site; other site 391735012485 aspartate-rich region 1; other site 391735012486 aspartate-rich region 2; other site 391735012487 trigger factor; Provisional; Region: tig; PRK01490 391735012488 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 391735012489 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 391735012490 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 391735012491 oligomer interface [polypeptide binding]; other site 391735012492 active site residues [active] 391735012493 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 391735012494 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 391735012495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735012496 Walker A motif; other site 391735012497 ATP binding site [chemical binding]; other site 391735012498 Walker B motif; other site 391735012499 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 391735012500 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 391735012501 Found in ATP-dependent protease La (LON); Region: LON; cl01056 391735012502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735012503 Walker A motif; other site 391735012504 ATP binding site [chemical binding]; other site 391735012505 Walker B motif; other site 391735012506 arginine finger; other site 391735012507 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 391735012508 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 391735012509 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391735012510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735012511 homodimer interface [polypeptide binding]; other site 391735012512 catalytic residue [active] 391735012513 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 391735012514 putative active site pocket [active] 391735012515 4-fold oligomerization interface [polypeptide binding]; other site 391735012516 metal binding residues [ion binding]; metal-binding site 391735012517 3-fold/trimer interface [polypeptide binding]; other site 391735012518 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 391735012519 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 391735012520 putative active site [active] 391735012521 oxyanion strand; other site 391735012522 catalytic triad [active] 391735012523 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 391735012524 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 391735012525 catalytic residues [active] 391735012526 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 391735012527 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 391735012528 substrate binding site [chemical binding]; other site 391735012529 glutamase interaction surface [polypeptide binding]; other site 391735012530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 391735012531 nucleotide binding region [chemical binding]; other site 391735012532 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391735012533 CoenzymeA binding site [chemical binding]; other site 391735012534 subunit interaction site [polypeptide binding]; other site 391735012535 PHB binding site; other site 391735012536 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391735012537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391735012538 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 391735012539 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391735012540 CoenzymeA binding site [chemical binding]; other site 391735012541 subunit interaction site [polypeptide binding]; other site 391735012542 PHB binding site; other site 391735012543 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 391735012544 phosphate binding site [ion binding]; other site 391735012545 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)...; Region: TLP_HIUase; cd05822 391735012546 active site 391735012547 homotetramer interface [polypeptide binding]; other site 391735012548 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 391735012549 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 391735012550 putative bifunctional OHCU decarboxylase/allantoate amidohydrolase; Provisional; Region: PRK13590 391735012551 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 391735012552 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 391735012553 active site 391735012554 metal binding site [ion binding]; metal-binding site 391735012555 dimer interface [polypeptide binding]; other site 391735012556 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 391735012557 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 391735012558 putative metal binding site [ion binding]; other site 391735012559 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 391735012560 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 391735012561 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 391735012562 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 391735012563 flagellar capping protein; Reviewed; Region: fliD; PRK08032 391735012564 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 391735012565 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 391735012566 flagellin; Provisional; Region: PRK12806 391735012567 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 391735012568 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 391735012569 flagellin; Provisional; Region: PRK12806 391735012570 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 391735012571 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 391735012572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 391735012573 TPR motif; other site 391735012574 binding surface 391735012575 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 391735012576 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 391735012577 GAF domain; Region: GAF; cl00853 391735012578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735012579 Walker A motif; other site 391735012580 ATP binding site [chemical binding]; other site 391735012581 Walker B motif; other site 391735012582 arginine finger; other site 391735012583 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 391735012584 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 391735012585 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 391735012586 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 391735012587 ring oligomerisation interface [polypeptide binding]; other site 391735012588 ATP/Mg binding site [chemical binding]; other site 391735012589 stacking interactions; other site 391735012590 hinge regions; other site 391735012591 Domain of unknown function DUF59; Region: DUF59; cl00941 391735012592 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cd01292 391735012593 active site 391735012594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735012595 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735012596 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735012597 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 391735012598 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 391735012599 dimerization interface [polypeptide binding]; other site 391735012600 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 391735012601 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391735012602 catalytic loop [active] 391735012603 iron binding site [ion binding]; other site 391735012604 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212 391735012605 FAD binding pocket [chemical binding]; other site 391735012606 FAD binding motif [chemical binding]; other site 391735012607 phosphate binding motif [ion binding]; other site 391735012608 beta-alpha-beta structure motif; other site 391735012609 NAD binding pocket [chemical binding]; other site 391735012610 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 391735012611 dimerization interface [polypeptide binding]; other site 391735012612 putative path to active site cavity [active] 391735012613 diiron center [ion binding]; other site 391735012614 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 391735012615 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 391735012616 NAD binding site [chemical binding]; other site 391735012617 substrate binding site [chemical binding]; other site 391735012618 catalytic Zn binding site [ion binding]; other site 391735012619 structural Zn binding site [ion binding]; other site 391735012620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735012621 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391735012622 extended (e) SDRs; Region: SDR_e; cd08946 391735012623 NAD(P) binding site [chemical binding]; other site 391735012624 substrate binding site [chemical binding]; other site 391735012625 active site 391735012626 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 391735012627 trimer interface [polypeptide binding]; other site 391735012628 active site 391735012629 substrate binding site [chemical binding]; other site 391735012630 CoA binding site [chemical binding]; other site 391735012631 Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421 391735012632 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 391735012633 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 391735012634 Cupin domain; Region: Cupin_2; cl09118 391735012635 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 391735012636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735012637 NAD(P) binding site [chemical binding]; other site 391735012638 active site 391735012639 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 391735012640 substrate binding site [chemical binding]; other site 391735012641 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 391735012642 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 391735012643 flagellar motor protein MotB; Validated; Region: motB; PRK09041 391735012644 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391735012645 ligand binding site [chemical binding]; other site 391735012646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735012647 Response regulator receiver domain; Region: Response_reg; pfam00072 391735012648 active site 391735012649 phosphorylation site [posttranslational modification] 391735012650 intermolecular recognition site; other site 391735012651 dimerization interface [polypeptide binding]; other site 391735012652 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 391735012653 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391735012654 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 391735012655 putative ligand binding site [chemical binding]; other site 391735012656 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 391735012657 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391735012658 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735012659 Walker A/P-loop; other site 391735012660 ATP binding site [chemical binding]; other site 391735012661 Q-loop/lid; other site 391735012662 ABC transporter signature motif; other site 391735012663 Walker B; other site 391735012664 D-loop; other site 391735012665 H-loop/switch region; other site 391735012666 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735012667 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 391735012668 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391735012669 TM-ABC transporter signature motif; other site 391735012670 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391735012671 TM-ABC transporter signature motif; other site 391735012672 cytosine deaminase; Provisional; Region: PRK05985 391735012673 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 391735012674 active site 391735012675 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012676 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012677 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012678 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012679 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012680 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012681 Equine herpesvirus glycoprotein gp2; Region: Herpes_gp2; pfam05955 391735012682 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012683 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012684 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012685 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012686 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012687 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735012688 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 391735012689 Lumazine binding domain; Region: Lum_binding; pfam00677 391735012690 Lumazine binding domain; Region: Lum_binding; pfam00677 391735012691 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735012692 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735012693 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391735012694 dimerization interface [polypeptide binding]; other site 391735012695 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 391735012696 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 391735012697 inhibitor-cofactor binding pocket; inhibition site 391735012698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735012699 catalytic residue [active] 391735012700 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 391735012701 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735012702 tetrameric interface [polypeptide binding]; other site 391735012703 NAD binding site [chemical binding]; other site 391735012704 catalytic residues [active] 391735012705 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 391735012706 intersubunit interface [polypeptide binding]; other site 391735012707 active site 391735012708 Zn2+ binding site [ion binding]; other site 391735012709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735012710 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735012711 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 391735012712 Proline dehydrogenase; Region: Pro_dh; cl03282 391735012713 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391735012714 NAD(P) binding site [chemical binding]; other site 391735012715 catalytic residues [active] 391735012716 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391735012717 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 391735012718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735012719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735012720 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 391735012721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735012722 putative substrate translocation pore; other site 391735012723 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 391735012724 putative phosphate binding site [ion binding]; other site 391735012725 putative catalytic site [active] 391735012726 active site 391735012727 metal binding site A [ion binding]; metal-binding site 391735012728 DNA binding site [nucleotide binding] 391735012729 putative AP binding site [nucleotide binding]; other site 391735012730 putative metal binding site B [ion binding]; other site 391735012731 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 391735012732 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 391735012733 THF binding site; other site 391735012734 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 391735012735 substrate binding site [chemical binding]; other site 391735012736 THF binding site; other site 391735012737 zinc-binding site [ion binding]; other site 391735012738 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 391735012739 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735012740 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 391735012741 putative dimerization interface [polypeptide binding]; other site 391735012742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 391735012743 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 391735012744 Domain of unknown function (DUF955); Region: DUF955; cl01076 391735012745 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 391735012746 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 391735012747 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 391735012748 oxalacetate binding site [chemical binding]; other site 391735012749 citrylCoA binding site [chemical binding]; other site 391735012750 coenzyme A binding site [chemical binding]; other site 391735012751 catalytic triad [active] 391735012752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735012753 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 391735012754 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 391735012755 hinge; other site 391735012756 active site 391735012757 BolA-like protein; Region: BolA; cl00386 391735012758 ABC-2 type transporter; Region: ABC2_membrane; cl11417 391735012759 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391735012760 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263 391735012761 Walker A/P-loop; other site 391735012762 ATP binding site [chemical binding]; other site 391735012763 Q-loop/lid; other site 391735012764 ABC transporter signature motif; other site 391735012765 Walker B; other site 391735012766 D-loop; other site 391735012767 H-loop/switch region; other site 391735012768 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 391735012769 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735012770 substrate binding site [chemical binding]; other site 391735012771 oxyanion hole (OAH) forming residues; other site 391735012772 trimer interface [polypeptide binding]; other site 391735012773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735012774 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391735012775 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 391735012776 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391735012777 dimer interface [polypeptide binding]; other site 391735012778 active site 391735012779 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 391735012780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 391735012781 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 391735012782 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 391735012783 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 391735012784 nucleotide binding pocket [chemical binding]; other site 391735012785 K-X-D-G motif; other site 391735012786 catalytic site [active] 391735012787 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 391735012788 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 391735012789 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 391735012790 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 391735012791 Dimer interface [polypeptide binding]; other site 391735012792 BRCT sequence motif; other site 391735012793 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 391735012794 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 391735012795 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 391735012796 Walker A/P-loop; other site 391735012797 ATP binding site [chemical binding]; other site 391735012798 Q-loop/lid; other site 391735012799 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 391735012800 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 391735012801 Q-loop/lid; other site 391735012802 ABC transporter signature motif; other site 391735012803 Walker B; other site 391735012804 D-loop; other site 391735012805 H-loop/switch region; other site 391735012806 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735012807 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391735012808 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735012809 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735012810 Walker A/P-loop; other site 391735012811 ATP binding site [chemical binding]; other site 391735012812 Q-loop/lid; other site 391735012813 ABC transporter signature motif; other site 391735012814 Walker B; other site 391735012815 D-loop; other site 391735012816 H-loop/switch region; other site 391735012817 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735012818 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735012819 Walker A/P-loop; other site 391735012820 ATP binding site [chemical binding]; other site 391735012821 Q-loop/lid; other site 391735012822 ABC transporter signature motif; other site 391735012823 Walker B; other site 391735012824 D-loop; other site 391735012825 H-loop/switch region; other site 391735012826 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735012827 TM-ABC transporter signature motif; other site 391735012828 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735012829 TM-ABC transporter signature motif; other site 391735012830 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 391735012831 ligand binding site [chemical binding]; other site 391735012832 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391735012833 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735012834 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 391735012835 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 391735012836 homotrimer interaction site [polypeptide binding]; other site 391735012837 putative active site [active] 391735012838 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 391735012839 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 391735012840 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391735012841 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 391735012842 DNA binding residues [nucleotide binding] 391735012843 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735012844 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735012845 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735012846 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735012847 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 391735012848 nucleophile elbow; other site 391735012849 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 391735012850 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 391735012851 active site 391735012852 HIGH motif; other site 391735012853 KMSKS motif; other site 391735012854 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 391735012855 tRNA binding surface [nucleotide binding]; other site 391735012856 anticodon binding site; other site 391735012857 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 391735012858 dimer interface [polypeptide binding]; other site 391735012859 putative tRNA-binding site [nucleotide binding]; other site 391735012860 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 391735012861 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 391735012862 dimer interface [polypeptide binding]; other site 391735012863 phosphorylation site [posttranslational modification] 391735012864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735012865 ATP binding site [chemical binding]; other site 391735012866 Mg2+ binding site [ion binding]; other site 391735012867 G-X-G motif; other site 391735012868 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391735012869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735012870 active site 391735012871 phosphorylation site [posttranslational modification] 391735012872 intermolecular recognition site; other site 391735012873 dimerization interface [polypeptide binding]; other site 391735012874 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 391735012875 Clp amino terminal domain; Region: Clp_N; pfam02861 391735012876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735012877 Walker A motif; other site 391735012878 ATP binding site [chemical binding]; other site 391735012879 Walker B motif; other site 391735012880 arginine finger; other site 391735012881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735012882 Walker A motif; other site 391735012883 ATP binding site [chemical binding]; other site 391735012884 Walker B motif; other site 391735012885 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 391735012886 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 391735012887 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 391735012888 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 391735012889 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 391735012890 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 391735012891 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 391735012892 generic binding surface II; other site 391735012893 generic binding surface I; other site 391735012894 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 391735012895 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 391735012896 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl09250 391735012897 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 391735012898 Active site [active] 391735012899 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391735012900 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391735012901 FAD binding domain; Region: FAD_binding_4; pfam01565 391735012902 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391735012903 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735012904 DNA-binding site [nucleotide binding]; DNA binding site 391735012905 FCD domain; Region: FCD; cl11656 391735012906 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 391735012907 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735012908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735012909 dimer interface [polypeptide binding]; other site 391735012910 conserved gate region; other site 391735012911 putative PBP binding loops; other site 391735012912 ABC-ATPase subunit interface; other site 391735012913 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391735012914 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391735012915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735012916 dimer interface [polypeptide binding]; other site 391735012917 conserved gate region; other site 391735012918 putative PBP binding loops; other site 391735012919 ABC-ATPase subunit interface; other site 391735012920 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 391735012921 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735012922 Walker A/P-loop; other site 391735012923 ATP binding site [chemical binding]; other site 391735012924 Q-loop/lid; other site 391735012925 ABC transporter signature motif; other site 391735012926 Walker B; other site 391735012927 D-loop; other site 391735012928 H-loop/switch region; other site 391735012929 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735012930 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735012931 Walker A/P-loop; other site 391735012932 ATP binding site [chemical binding]; other site 391735012933 Q-loop/lid; other site 391735012934 ABC transporter signature motif; other site 391735012935 Walker B; other site 391735012936 D-loop; other site 391735012937 H-loop/switch region; other site 391735012938 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735012939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735012940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735012941 galactonate dehydratase; Provisional; Region: PRK14017 391735012942 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues...; Region: MR_like; cd03316 391735012943 active site pocket [active] 391735012944 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735012945 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 391735012946 NAD(P) binding site [chemical binding]; other site 391735012947 catalytic residues [active] 391735012948 catalytic residues [active] 391735012949 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391735012950 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391735012951 DNA binding site [nucleotide binding] 391735012952 domain linker motif; other site 391735012953 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 391735012954 putative dimerization interface [polypeptide binding]; other site 391735012955 putative ligand binding site [chemical binding]; other site 391735012956 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391735012957 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735012958 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391735012959 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 391735012960 Walker A/P-loop; other site 391735012961 ATP binding site [chemical binding]; other site 391735012962 Q-loop/lid; other site 391735012963 ABC transporter signature motif; other site 391735012964 Walker B; other site 391735012965 D-loop; other site 391735012966 H-loop/switch region; other site 391735012967 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391735012968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735012969 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 391735012970 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391735012971 PYR/PP interface [polypeptide binding]; other site 391735012972 dimer interface [polypeptide binding]; other site 391735012973 TPP binding site [chemical binding]; other site 391735012974 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391735012975 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 391735012976 TPP-binding site [chemical binding]; other site 391735012977 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735012978 classical (c) SDRs; Region: SDR_c; cd05233 391735012979 NAD(P) binding site [chemical binding]; other site 391735012980 active site 391735012981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735012982 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735012983 classical (c) SDRs; Region: SDR_c; cd05233 391735012984 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735012985 NAD(P) binding site [chemical binding]; other site 391735012986 active site 391735012987 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391735012988 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391735012989 DNA binding site [nucleotide binding] 391735012990 domain linker motif; other site 391735012991 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 391735012992 putative dimerization interface [polypeptide binding]; other site 391735012993 putative ligand binding site [chemical binding]; other site 391735012994 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391735012995 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735012996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735012997 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391735012998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735012999 dimer interface [polypeptide binding]; other site 391735013000 conserved gate region; other site 391735013001 putative PBP binding loops; other site 391735013002 ABC-ATPase subunit interface; other site 391735013003 choline dehydrogenase; Validated; Region: PRK02106 391735013004 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391735013005 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735013006 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391735013007 tetramerization interface [polypeptide binding]; other site 391735013008 NAD(P) binding site [chemical binding]; other site 391735013009 catalytic residues [active] 391735013010 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391735013011 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 391735013012 Walker A/P-loop; other site 391735013013 ATP binding site [chemical binding]; other site 391735013014 Q-loop/lid; other site 391735013015 ABC transporter signature motif; other site 391735013016 Walker B; other site 391735013017 D-loop; other site 391735013018 H-loop/switch region; other site 391735013019 TOBE domain; Region: TOBE_2; cl01440 391735013020 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 391735013021 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 391735013022 Dehydratase family; Region: ILVD_EDD; cl00340 391735013023 putative transposase OrfB; Reviewed; Region: PHA02517 391735013024 Integrase core domain; Region: rve; cl01316 391735013025 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 391735013026 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 391735013027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735013028 putative substrate translocation pore; other site 391735013029 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735013030 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391735013031 catalytic residue [active] 391735013032 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735013033 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 391735013034 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391735013035 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735013036 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735013037 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 391735013038 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 391735013039 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 391735013040 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391735013041 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 391735013042 putative hydrophobic ligand binding site [chemical binding]; other site 391735013043 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 391735013044 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 391735013045 MoxR-like ATPases [General function prediction only]; Region: COG0714 391735013046 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 391735013047 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 391735013048 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391735013049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735013050 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013051 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 391735013052 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 391735013053 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 391735013054 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 391735013055 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391735013056 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391735013057 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 391735013058 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391735013059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735013060 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391735013061 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735013063 dimer interface [polypeptide binding]; other site 391735013064 conserved gate region; other site 391735013065 putative PBP binding loops; other site 391735013066 ABC-ATPase subunit interface; other site 391735013067 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391735013068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735013069 dimer interface [polypeptide binding]; other site 391735013070 conserved gate region; other site 391735013071 putative PBP binding loops; other site 391735013072 ABC-ATPase subunit interface; other site 391735013073 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391735013074 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 391735013075 MutS domain I; Region: MutS_I; pfam01624 391735013076 MutS domain II; Region: MutS_II; pfam05188 391735013077 MutS family domain IV; Region: MutS_IV; pfam05190 391735013078 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735013079 Walker A/P-loop; other site 391735013080 ATP binding site [chemical binding]; other site 391735013081 Q-loop/lid; other site 391735013082 ABC transporter signature motif; other site 391735013083 Walker B; other site 391735013084 D-loop; other site 391735013085 H-loop/switch region; other site 391735013086 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 391735013087 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 391735013088 Protein of unknown function, DUF484; Region: DUF484; cl01228 391735013089 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 391735013090 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391735013091 DNA binding site [nucleotide binding] 391735013092 Int/Topo IB signature motif; other site 391735013093 active site 391735013094 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 391735013095 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 391735013096 P-loop, Walker A motif; other site 391735013097 Base recognition motif; other site 391735013098 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 391735013099 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 391735013100 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 391735013101 active site 391735013102 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 391735013103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735013104 Walker A motif; other site 391735013105 ATP binding site [chemical binding]; other site 391735013106 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735013107 MraZ protein; Region: MraZ; pfam02381 391735013108 MraZ protein; Region: MraZ; pfam02381 391735013109 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 391735013110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735013111 Septum formation initiator; Region: DivIC; cl11433 391735013112 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 391735013113 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 391735013114 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 391735013115 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 391735013116 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391735013117 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391735013118 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391735013119 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 391735013120 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391735013121 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 391735013122 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 391735013123 Mg++ binding site [ion binding]; other site 391735013124 putative catalytic motif [active] 391735013125 putative substrate binding site [chemical binding]; other site 391735013126 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 391735013127 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391735013128 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 391735013129 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 391735013130 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 391735013131 active site 391735013132 homodimer interface [polypeptide binding]; other site 391735013133 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 391735013134 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391735013135 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391735013136 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391735013137 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 391735013138 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 391735013139 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735013140 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 391735013141 Cell division protein FtsQ; Region: FtsQ; pfam03799 391735013142 cell division protein FtsA; Region: ftsA; TIGR01174 391735013143 Cell division protein FtsA; Region: FtsA; cl11496 391735013144 Cell division protein FtsA; Region: FtsA; cl11496 391735013145 cell division protein FtsZ; Validated; Region: PRK09330 391735013146 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 391735013147 nucleotide binding site [chemical binding]; other site 391735013148 SulA interaction site; other site 391735013149 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735013150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735013151 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 391735013152 putative substrate binding pocket [chemical binding]; other site 391735013153 dimerization interface [polypeptide binding]; other site 391735013154 LamB/YcsF family; Region: LamB_YcsF; cl00664 391735013155 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 391735013156 carboxyltransferase (CT) interaction site; other site 391735013157 biotinylation site [posttranslational modification]; other site 391735013158 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 391735013159 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391735013160 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735013161 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 391735013162 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 391735013163 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 391735013164 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 391735013165 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 391735013166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735013167 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391735013168 putative substrate translocation pore; other site 391735013169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735013170 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 391735013171 active site 391735013172 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 391735013173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735013174 Walker A motif; other site 391735013175 ATP binding site [chemical binding]; other site 391735013176 Walker B motif; other site 391735013177 arginine finger; other site 391735013178 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 391735013179 Fic family protein [Function unknown]; Region: COG3177 391735013180 Fic/DOC family; Region: Fic; cl00960 391735013181 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391735013182 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 391735013183 putative active site [active] 391735013184 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 391735013185 catalytic nucleophile [active] 391735013186 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 391735013187 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735013188 Walker A/P-loop; other site 391735013189 ATP binding site [chemical binding]; other site 391735013190 Q-loop/lid; other site 391735013191 ABC transporter signature motif; other site 391735013192 Walker B; other site 391735013193 D-loop; other site 391735013194 H-loop/switch region; other site 391735013195 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735013196 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735013197 Walker A/P-loop; other site 391735013198 ATP binding site [chemical binding]; other site 391735013199 Q-loop/lid; other site 391735013200 ABC transporter signature motif; other site 391735013201 Walker B; other site 391735013202 D-loop; other site 391735013203 H-loop/switch region; other site 391735013204 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735013205 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 391735013206 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 391735013207 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 391735013208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735013209 dimer interface [polypeptide binding]; other site 391735013210 conserved gate region; other site 391735013211 putative PBP binding loops; other site 391735013212 ABC-ATPase subunit interface; other site 391735013213 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 391735013214 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391735013215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735013216 dimer interface [polypeptide binding]; other site 391735013217 conserved gate region; other site 391735013218 putative PBP binding loops; other site 391735013219 ABC-ATPase subunit interface; other site 391735013220 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 391735013221 homodimer interface [polypeptide binding]; other site 391735013222 homotetramer interface [polypeptide binding]; other site 391735013223 active site pocket [active] 391735013224 cleavage site 391735013225 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 391735013226 SxDxEG motif; other site 391735013227 active site 391735013228 metal binding site [ion binding]; metal-binding site 391735013229 homopentamer interface [polypeptide binding]; other site 391735013230 fumarate hydratase; Reviewed; Region: fumC; PRK00485 391735013231 Class II fumarases; Region: Fumarase_classII; cd01362 391735013232 active site 391735013233 tetramer interface [polypeptide binding]; other site 391735013234 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013235 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 391735013236 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 391735013237 tetramer interface [polypeptide binding]; other site 391735013238 active site 391735013239 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391735013240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735013241 DNA-binding site [nucleotide binding]; DNA binding site 391735013242 UTRA domain; Region: UTRA; cl06649 391735013243 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735013244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735013245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391735013246 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391735013247 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391735013248 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 391735013249 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 391735013250 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735013251 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 391735013252 inter-subunit interface; other site 391735013253 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 391735013254 iron-sulfur cluster [ion binding]; other site 391735013255 [2Fe-2S] cluster binding site [ion binding]; other site 391735013256 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 391735013257 putative alpha subunit interface [polypeptide binding]; other site 391735013258 putative active site [active] 391735013259 putative substrate binding site [chemical binding]; other site 391735013260 Fe binding site [ion binding]; other site 391735013261 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735013262 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735013263 Walker A/P-loop; other site 391735013264 ATP binding site [chemical binding]; other site 391735013265 Q-loop/lid; other site 391735013266 ABC transporter signature motif; other site 391735013267 Walker B; other site 391735013268 D-loop; other site 391735013269 H-loop/switch region; other site 391735013270 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735013271 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735013272 Walker A/P-loop; other site 391735013273 ATP binding site [chemical binding]; other site 391735013274 Q-loop/lid; other site 391735013275 ABC transporter signature motif; other site 391735013276 Walker B; other site 391735013277 D-loop; other site 391735013278 H-loop/switch region; other site 391735013279 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735013280 TM-ABC transporter signature motif; other site 391735013281 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735013282 TM-ABC transporter signature motif; other site 391735013283 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735013284 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 391735013285 putative ligand binding site [chemical binding]; other site 391735013286 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 391735013287 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 391735013288 active site 391735013289 dimer interface [polypeptide binding]; other site 391735013290 metal binding site [ion binding]; metal-binding site 391735013291 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 391735013292 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 391735013293 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 391735013294 dimer interface [polypeptide binding]; other site 391735013295 active site 391735013296 LysR family transcriptional regulator; Provisional; Region: PRK14997 391735013297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735013298 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391735013299 putative effector binding pocket; other site 391735013300 dimerization interface [polypeptide binding]; other site 391735013301 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735013302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735013303 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 391735013304 putative dimerization interface [polypeptide binding]; other site 391735013305 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735013306 enoyl-CoA hydratase; Provisional; Region: PRK06143 391735013307 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735013308 substrate binding site [chemical binding]; other site 391735013309 oxyanion hole (OAH) forming residues; other site 391735013310 trimer interface [polypeptide binding]; other site 391735013311 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 391735013312 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735013313 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735013314 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735013315 active site 391735013316 Coenzyme A transferase; Region: CoA_trans; cl00773 391735013317 Coenzyme A transferase; Region: CoA_trans; cl00773 391735013318 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735013319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735013320 NAD(P) binding site [chemical binding]; other site 391735013321 active site 391735013322 thiolase; Provisional; Region: PRK06158 391735013323 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 391735013324 active site 391735013325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735013326 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013327 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 391735013328 dimer interface [polypeptide binding]; other site 391735013329 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 391735013330 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391735013331 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 391735013332 Zn binding site [ion binding]; other site 391735013333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735013334 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013335 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 391735013336 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735013337 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 391735013338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cl10457 391735013339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735013340 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 391735013341 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013342 dimerization interface [polypeptide binding]; other site 391735013343 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735013344 Uncharacterized conserved protein [Function unknown]; Region: COG5361 391735013345 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 391735013346 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 391735013347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735013348 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735013350 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013351 Transposase domain (DUF772); Region: DUF772; cl12084 391735013352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735013353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735013354 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 391735013355 substrate binding pocket [chemical binding]; other site 391735013356 dimerization interface [polypeptide binding]; other site 391735013357 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 391735013358 trimer interface [polypeptide binding]; other site 391735013359 eyelet of channel; other site 391735013360 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 391735013361 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735013362 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 391735013363 ligand binding site [chemical binding]; other site 391735013364 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735013365 TM-ABC transporter signature motif; other site 391735013366 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735013367 TM-ABC transporter signature motif; other site 391735013368 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735013369 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735013370 Walker A/P-loop; other site 391735013371 ATP binding site [chemical binding]; other site 391735013372 Q-loop/lid; other site 391735013373 ABC transporter signature motif; other site 391735013374 Walker B; other site 391735013375 D-loop; other site 391735013376 H-loop/switch region; other site 391735013377 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735013378 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735013379 Walker A/P-loop; other site 391735013380 ATP binding site [chemical binding]; other site 391735013381 Q-loop/lid; other site 391735013382 ABC transporter signature motif; other site 391735013383 Walker B; other site 391735013384 D-loop; other site 391735013385 H-loop/switch region; other site 391735013386 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 391735013387 Zn binding site [ion binding]; other site 391735013388 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391735013389 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 391735013390 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 391735013391 substrate binding site [chemical binding]; other site 391735013392 ligand binding site [chemical binding]; other site 391735013393 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391735013394 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved...; Region: MR_like_1; cd03326 391735013395 putative active site pocket [active] 391735013396 metal binding site [ion binding]; metal-binding site 391735013397 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 391735013398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735013399 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 391735013400 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 391735013401 substrate binding site [chemical binding]; other site 391735013402 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013403 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 391735013404 active site 391735013405 NTP binding site [chemical binding]; other site 391735013406 metal binding triad [ion binding]; metal-binding site 391735013407 Domain of unknown function (DUF955); Region: DUF955; cl01076 391735013408 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; cl11557 391735013409 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 391735013410 active site 391735013411 nucleophile elbow; other site 391735013412 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 391735013413 ATP binding site [chemical binding]; other site 391735013414 substrate interface [chemical binding]; other site 391735013415 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391735013416 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391735013417 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl02583 391735013418 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391735013419 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_5; cd06281 391735013420 putative dimerization interface [polypeptide binding]; other site 391735013421 putative ligand binding site [chemical binding]; other site 391735013422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735013423 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013424 acyl-CoA synthetase; Validated; Region: PRK06188 391735013425 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735013426 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735013427 classical (c) SDRs; Region: SDR_c; cd05233 391735013428 NAD(P) binding site [chemical binding]; other site 391735013429 active site 391735013430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735013431 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013432 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA)...; Region: CCL_ACL-C; cd06100 391735013433 active site 391735013434 oxalacetate binding site [chemical binding]; other site 391735013435 citrylCoA binding site [chemical binding]; other site 391735013436 coenzyme A binding site [chemical binding]; other site 391735013437 catalytic triad [active] 391735013438 Putative cyclase; Region: Cyclase; cl00814 391735013439 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391735013440 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391735013441 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 391735013442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735013443 Walker A motif; other site 391735013444 ATP binding site [chemical binding]; other site 391735013445 Walker B motif; other site 391735013446 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 391735013447 putative transposase OrfB; Reviewed; Region: PHA02517 391735013448 Integrase core domain; Region: rve; cl01316 391735013449 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735013450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735013451 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391735013452 dimerization interface [polypeptide binding]; other site 391735013453 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 391735013454 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 391735013455 Glutamate binding site [chemical binding]; other site 391735013456 NAD binding site [chemical binding]; other site 391735013457 catalytic residues [active] 391735013458 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 391735013459 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 391735013460 inhibitor site; inhibition site 391735013461 active site 391735013462 dimer interface [polypeptide binding]; other site 391735013463 catalytic residue [active] 391735013464 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391735013465 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013466 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391735013467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735013468 dimer interface [polypeptide binding]; other site 391735013469 conserved gate region; other site 391735013470 putative PBP binding loops; other site 391735013471 ABC-ATPase subunit interface; other site 391735013472 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391735013473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735013474 dimer interface [polypeptide binding]; other site 391735013475 conserved gate region; other site 391735013476 putative PBP binding loops; other site 391735013477 ABC-ATPase subunit interface; other site 391735013478 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391735013479 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735013480 Walker A/P-loop; other site 391735013481 ATP binding site [chemical binding]; other site 391735013482 Q-loop/lid; other site 391735013483 ABC transporter signature motif; other site 391735013484 Walker B; other site 391735013485 D-loop; other site 391735013486 H-loop/switch region; other site 391735013487 TOBE domain; Region: TOBE_2; cl01440 391735013488 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391735013489 FAD binding domain; Region: FAD_binding_4; pfam01565 391735013490 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 391735013491 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 391735013492 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 391735013493 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 391735013494 Ligand binding site [chemical binding]; other site 391735013495 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391735013496 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391735013497 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735013498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391735013499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391735013500 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 391735013501 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735013502 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391735013503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735013504 DNA-binding site [nucleotide binding]; DNA binding site 391735013505 FCD domain; Region: FCD; cl11656 391735013506 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735013507 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 391735013508 putative ligand binding site [chemical binding]; other site 391735013509 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735013510 TM-ABC transporter signature motif; other site 391735013511 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735013512 TM-ABC transporter signature motif; other site 391735013513 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391735013514 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735013515 Walker A/P-loop; other site 391735013516 ATP binding site [chemical binding]; other site 391735013517 Q-loop/lid; other site 391735013518 ABC transporter signature motif; other site 391735013519 Walker B; other site 391735013520 D-loop; other site 391735013521 H-loop/switch region; other site 391735013522 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735013523 Walker A/P-loop; other site 391735013524 ATP binding site [chemical binding]; other site 391735013525 Q-loop/lid; other site 391735013526 ABC transporter signature motif; other site 391735013527 Walker B; other site 391735013528 D-loop; other site 391735013529 H-loop/switch region; other site 391735013530 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391735013531 classical (c) SDRs; Region: SDR_c; cd05233 391735013532 NAD(P) binding site [chemical binding]; other site 391735013533 active site 391735013534 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 391735013535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735013536 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391735013537 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 391735013538 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735013539 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 391735013540 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 391735013541 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 391735013542 putative transposase OrfB; Reviewed; Region: PHA02517 391735013543 Integrase core domain; Region: rve; cl01316 391735013544 Phage-related minor tail protein [Function unknown]; Region: COG5281 391735013545 Mu-like prophage protein [General function prediction only]; Region: COG3941; cl09192 391735013546 Phd_YefM; Region: PhdYeFM; cl09153 391735013547 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 391735013548 oligomeric interface; other site 391735013549 putative active site [active] 391735013550 homodimer interface [polypeptide binding]; other site 391735013551 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 391735013552 active site 391735013553 substrate binding site [chemical binding]; other site 391735013554 trimer interface [polypeptide binding]; other site 391735013555 CoA binding site [chemical binding]; other site 391735013556 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 391735013557 Chlorophyllase enzyme; Region: Chlorophyllase2; cl14889 391735013558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391735013559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391735013560 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 391735013561 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391735013562 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391735013563 active site 391735013564 HIGH motif; other site 391735013565 nucleotide binding site [chemical binding]; other site 391735013566 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391735013567 active site 391735013568 KMSKS motif; other site 391735013569 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391735013570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391735013571 DNA-binding site [nucleotide binding]; DNA binding site 391735013572 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391735013573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735013574 homodimer interface [polypeptide binding]; other site 391735013575 catalytic residue [active] 391735013576 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735013577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735013578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013579 dimerization interface [polypeptide binding]; other site 391735013580 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735013581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735013582 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391735013583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735013584 dimer interface [polypeptide binding]; other site 391735013585 conserved gate region; other site 391735013586 putative PBP binding loops; other site 391735013587 ABC-ATPase subunit interface; other site 391735013588 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391735013589 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735013590 Walker A/P-loop; other site 391735013591 ATP binding site [chemical binding]; other site 391735013592 Q-loop/lid; other site 391735013593 ABC transporter signature motif; other site 391735013594 Walker B; other site 391735013595 D-loop; other site 391735013596 H-loop/switch region; other site 391735013597 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735013598 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735013599 Walker A/P-loop; other site 391735013600 ATP binding site [chemical binding]; other site 391735013601 Q-loop/lid; other site 391735013602 ABC transporter signature motif; other site 391735013603 Walker B; other site 391735013604 D-loop; other site 391735013605 H-loop/switch region; other site 391735013606 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735013607 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391735013608 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 391735013609 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 391735013610 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391735013611 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 391735013612 metal binding site [ion binding]; metal-binding site 391735013613 putative dimer interface [polypeptide binding]; other site 391735013614 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 391735013615 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 391735013616 metal binding site [ion binding]; metal-binding site 391735013617 putative dimer interface [polypeptide binding]; other site 391735013618 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 391735013619 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735013620 Walker A/P-loop; other site 391735013621 ATP binding site [chemical binding]; other site 391735013622 Q-loop/lid; other site 391735013623 ABC transporter signature motif; other site 391735013624 Walker B; other site 391735013625 D-loop; other site 391735013626 H-loop/switch region; other site 391735013627 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735013628 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735013629 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735013630 Walker A/P-loop; other site 391735013631 ATP binding site [chemical binding]; other site 391735013632 Q-loop/lid; other site 391735013633 ABC transporter signature motif; other site 391735013634 Walker B; other site 391735013635 D-loop; other site 391735013636 H-loop/switch region; other site 391735013637 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735013638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 391735013639 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735013640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735013641 dimer interface [polypeptide binding]; other site 391735013642 conserved gate region; other site 391735013643 putative PBP binding loops; other site 391735013644 ABC-ATPase subunit interface; other site 391735013645 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 391735013646 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391735013647 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735013648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735013649 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013650 dimerization interface [polypeptide binding]; other site 391735013651 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391735013652 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391735013653 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 391735013654 substrate binding pocket [chemical binding]; other site 391735013655 membrane-bound complex binding site; other site 391735013656 hinge residues; other site 391735013657 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735013658 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 391735013659 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 391735013660 N-terminal plug; other site 391735013661 ligand-binding site [chemical binding]; other site 391735013662 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 391735013663 benzoate transport; Region: 2A0115; TIGR00895 391735013664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735013665 putative substrate translocation pore; other site 391735013666 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 391735013667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735013668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735013669 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391735013670 dimerization interface [polypeptide binding]; other site 391735013671 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 391735013672 hypothetical protein; Provisional; Region: PRK08185 391735013673 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 391735013674 intersubunit interface [polypeptide binding]; other site 391735013675 active site 391735013676 zinc binding site [ion binding]; other site 391735013677 Na+ binding site [ion binding]; other site 391735013678 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 391735013679 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 391735013680 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 391735013681 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 391735013682 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 391735013683 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735013684 ABC transporter signature motif; other site 391735013685 Walker B; other site 391735013686 D-loop; other site 391735013687 H-loop/switch region; other site 391735013688 TOBE domain; Region: TOBE_2; cl01440 391735013689 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 391735013690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735013691 dimer interface [polypeptide binding]; other site 391735013692 conserved gate region; other site 391735013693 putative PBP binding loops; other site 391735013694 ABC-ATPase subunit interface; other site 391735013695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735013696 dimer interface [polypeptide binding]; other site 391735013697 conserved gate region; other site 391735013698 putative PBP binding loops; other site 391735013699 ABC-ATPase subunit interface; other site 391735013700 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391735013701 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013702 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 391735013703 active site 391735013704 Zn-binding site [ion binding]; other site 391735013705 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 391735013706 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 391735013707 ATP binding site [chemical binding]; other site 391735013708 Mg++ binding site [ion binding]; other site 391735013709 motif III; other site 391735013710 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391735013711 nucleotide binding region [chemical binding]; other site 391735013712 ATP-binding site [chemical binding]; other site 391735013713 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 391735013714 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 391735013715 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735013716 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 391735013717 ABC transporter; Region: ABC_tran_2; pfam12848 391735013718 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 391735013719 Protein of unknown function (DUF1631); Region: DUF1631; pfam07793 391735013720 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 391735013721 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 391735013722 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391735013723 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 391735013724 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391735013725 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391735013726 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391735013727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 391735013728 S-adenosylmethionine binding site [chemical binding]; other site 391735013729 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 391735013730 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 391735013731 active site 391735013732 (T/H)XGH motif; other site 391735013733 diaminopimelate decarboxylase; Provisional; Region: PRK11165 391735013734 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 391735013735 active site 391735013736 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391735013737 substrate binding site [chemical binding]; other site 391735013738 catalytic residues [active] 391735013739 dimer interface [polypeptide binding]; other site 391735013740 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013741 Fatty acid desaturase; Region: FA_desaturase; pfam00487 391735013742 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 391735013743 Creatinine amidohydrolase; Region: Creatininase; cl00618 391735013744 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391735013745 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 391735013746 Cell division protein ZapA; Region: ZapA; cl01146 391735013747 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 391735013748 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 391735013749 N-terminal plug; other site 391735013750 ligand-binding site [chemical binding]; other site 391735013751 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 391735013752 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 391735013753 intersubunit interface [polypeptide binding]; other site 391735013754 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 391735013755 dimer interface [polypeptide binding]; other site 391735013756 putative PBP binding regions; other site 391735013757 ABC-ATPase subunit interface; other site 391735013758 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 391735013759 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 391735013760 homodimer interface [polypeptide binding]; other site 391735013761 Walker A motif; other site 391735013762 ATP binding site [chemical binding]; other site 391735013763 hydroxycobalamin binding site [chemical binding]; other site 391735013764 Walker B motif; other site 391735013765 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 391735013766 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 391735013767 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 391735013768 catalytic triad [active] 391735013769 EBNA-3B; Provisional; Region: PHA03378 391735013770 Peptidase family M23; Region: Peptidase_M23; pfam01551 391735013771 O-Antigen ligase; Region: Wzy_C; cl04850 391735013772 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 391735013773 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 391735013774 Pilin (bacterial filament); Region: Pilin; pfam00114 391735013775 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 391735013776 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 391735013777 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 391735013778 phosphopeptide binding site; other site 391735013779 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 391735013780 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 391735013781 tandem repeat interface [polypeptide binding]; other site 391735013782 oligomer interface [polypeptide binding]; other site 391735013783 active site residues [active] 391735013784 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 391735013785 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 391735013786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 391735013787 motif II; other site 391735013788 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 391735013789 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 391735013790 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 391735013791 active site 391735013792 ribonuclease E; Reviewed; Region: rne; PRK10811 391735013793 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 391735013794 homodimer interface [polypeptide binding]; other site 391735013795 oligonucleotide binding site [chemical binding]; other site 391735013796 Protein of unknown function (DUF328); Region: DUF328; cl01143 391735013797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 391735013798 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 391735013799 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 391735013800 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 391735013801 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 391735013802 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 391735013803 dimerization interface [polypeptide binding]; other site 391735013804 active site 391735013805 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 391735013806 homopentamer interface [polypeptide binding]; other site 391735013807 active site 391735013808 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 391735013809 putative RNA binding site [nucleotide binding]; other site 391735013810 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 391735013811 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 391735013812 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 391735013813 TolA protein; Region: tolA_full; TIGR02794 391735013814 TolA protein; Region: tolA_full; TIGR02794 391735013815 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 391735013816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735013817 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013818 Cupin domain; Region: Cupin_2; cl09118 391735013819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735013820 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013821 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 391735013822 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 391735013823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735013824 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735013826 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013827 CoA-transferase family III; Region: CoA_transf_3; cl00778 391735013828 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391735013829 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735013830 active site 391735013831 Uncharacterized conserved protein [Function unknown]; Region: COG3777 391735013832 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391735013833 active site 2 [active] 391735013834 active site 1 [active] 391735013835 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a...; Region: RNase_Sa; cd00607 391735013836 active site 391735013837 barstar interaction site; other site 391735013838 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 391735013839 putative RNAase interaction site [polypeptide binding]; other site 391735013840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 391735013841 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 391735013842 SurA N-terminal domain; Region: SurA_N; pfam09312 391735013843 PPIC-type PPIASE domain; Region: Rotamase; cl08278 391735013844 PPIC-type PPIASE domain; Region: Rotamase; cl08278 391735013845 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 391735013846 Organic solvent tolerance protein; Region: OstA_C; pfam04453 391735013847 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 391735013848 Phosphotransferase enzyme family; Region: APH; pfam01636 391735013849 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 391735013850 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391735013851 DctM-like transporters; Region: DctM; pfam06808 391735013852 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 391735013853 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 391735013854 classical (c) SDRs; Region: SDR_c; cd05233 391735013855 NAD(P) binding site [chemical binding]; other site 391735013856 active site 391735013857 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391735013858 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735013859 Walker A/P-loop; other site 391735013860 ATP binding site [chemical binding]; other site 391735013861 Q-loop/lid; other site 391735013862 ABC transporter signature motif; other site 391735013863 Walker B; other site 391735013864 D-loop; other site 391735013865 H-loop/switch region; other site 391735013866 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391735013867 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735013868 Walker A/P-loop; other site 391735013869 ATP binding site [chemical binding]; other site 391735013870 Q-loop/lid; other site 391735013871 ABC transporter signature motif; other site 391735013872 Walker B; other site 391735013873 D-loop; other site 391735013874 H-loop/switch region; other site 391735013875 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735013876 TM-ABC transporter signature motif; other site 391735013877 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735013878 TM-ABC transporter signature motif; other site 391735013879 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735013880 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 391735013881 putative ligand binding site [chemical binding]; other site 391735013882 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 391735013883 rRNA binding site [nucleotide binding]; other site 391735013884 predicted 30S ribosome binding site; other site 391735013885 LysE type translocator; Region: LysE; cl00565 391735013886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735013887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735013888 MltA specific insert domain; Region: MltA; pfam03562 391735013889 3D domain; Region: 3D; cl01439 391735013890 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 391735013891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 391735013892 active site 391735013893 phosphorylation site [posttranslational modification] 391735013894 intermolecular recognition site; other site 391735013895 dimerization interface [polypeptide binding]; other site 391735013896 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 391735013897 dimerization interface [polypeptide binding]; other site 391735013898 DNA binding residues [nucleotide binding] 391735013899 60S ribosomal protein L19-like protein; Provisional; Region: PTZ00436 391735013900 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 391735013901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391735013902 putative active site [active] 391735013903 heme pocket [chemical binding]; other site 391735013904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 391735013905 dimer interface [polypeptide binding]; other site 391735013906 phosphorylation site [posttranslational modification] 391735013907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391735013908 ATP binding site [chemical binding]; other site 391735013909 Mg2+ binding site [ion binding]; other site 391735013910 G-X-G motif; other site 391735013911 TIGR02099 family protein; Region: TIGR02099 391735013912 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391735013913 metal binding triad; other site 391735013914 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 391735013915 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 391735013916 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391735013917 metal binding triad; other site 391735013918 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391735013919 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391735013920 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391735013921 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 391735013922 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 391735013923 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 391735013924 Cytochrome c; Region: Cytochrom_C; cl11414 391735013925 Cytochrome c; Region: Cytochrom_C; cl11414 391735013926 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 391735013927 G1 box; other site 391735013928 GTP/Mg2+ binding site [chemical binding]; other site 391735013929 Switch I region; other site 391735013930 G2 box; other site 391735013931 G3 box; other site 391735013932 Switch II region; other site 391735013933 G4 box; other site 391735013934 G5 box; other site 391735013935 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 391735013936 putative acyl-acceptor binding pocket; other site 391735013937 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 391735013938 putative acyl-acceptor binding pocket; other site 391735013939 S-adenosylmethionine synthetase; Validated; Region: PRK05250 391735013940 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 391735013941 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 391735013942 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 391735013943 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 391735013944 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391735013945 active site 391735013946 nucleotide binding site [chemical binding]; other site 391735013947 HIGH motif; other site 391735013948 KMSKS motif; other site 391735013949 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 391735013950 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 391735013951 active site 391735013952 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 391735013953 dimer interface [polypeptide binding]; other site 391735013954 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 391735013955 Ligand Binding Site [chemical binding]; other site 391735013956 Molecular Tunnel; other site 391735013957 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391735013958 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391735013959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735013960 NAD(P) binding site [chemical binding]; other site 391735013961 active site 391735013962 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 391735013963 ligand binding site [chemical binding]; other site 391735013964 tetramer interface [polypeptide binding]; other site 391735013965 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 391735013966 NeuB family; Region: NeuB; cl00496 391735013967 SAF domain; Region: SAF; cl00555 391735013968 FemAB family; Region: FemAB; cl11444 391735013969 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 391735013970 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 391735013971 active site 391735013972 homodimer interface [polypeptide binding]; other site 391735013973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 391735013974 S-adenosylmethionine binding site [chemical binding]; other site 391735013975 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 391735013976 FOG: CBS domain [General function prediction only]; Region: COG0517 391735013977 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 391735013978 Substrate binding site [chemical binding]; other site 391735013979 metal binding site [ion binding]; metal-binding site 391735013980 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 391735013981 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 391735013982 inhibitor-cofactor binding pocket; inhibition site 391735013983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735013984 catalytic residue [active] 391735013985 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 391735013986 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391735013987 NAD binding site [chemical binding]; other site 391735013988 substrate binding site [chemical binding]; other site 391735013989 active site 391735013990 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 391735013991 glutamase interaction surface [polypeptide binding]; other site 391735013992 substrate binding site [chemical binding]; other site 391735013993 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 391735013994 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 391735013995 putative active site [active] 391735013996 oxyanion strand; other site 391735013997 catalytic triad [active] 391735013998 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 391735013999 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 391735014000 NAD(P) binding site [chemical binding]; other site 391735014001 homodimer interface [polypeptide binding]; other site 391735014002 substrate binding site [chemical binding]; other site 391735014003 active site 391735014004 Found in ATP-dependent protease La (LON); Region: LON; cl01056 391735014005 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 391735014006 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 391735014007 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735014008 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 391735014009 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 391735014010 substrate binding site [chemical binding]; other site 391735014011 active site 391735014012 catalytic residues [active] 391735014013 heterodimer interface [polypeptide binding]; other site 391735014014 tryptophan synthase, beta chain; Region: PLN02618 391735014015 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 391735014016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735014017 catalytic residue [active] 391735014018 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 391735014019 active site 391735014020 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 391735014021 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 391735014022 dimerization interface 3.5A [polypeptide binding]; other site 391735014023 active site 391735014024 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 391735014025 FimV N-terminal domain; Region: FimV_core; TIGR03505 391735014026 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 391735014027 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 391735014028 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 391735014029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735014030 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 391735014031 PAS fold; Region: PAS; pfam00989 391735014032 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391735014033 putative active site [active] 391735014034 heme pocket [chemical binding]; other site 391735014035 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391735014036 metal binding site [ion binding]; metal-binding site 391735014037 active site 391735014038 I-site; other site 391735014039 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 391735014040 transcriptional activator FtrB; Provisional; Region: ftrB; PRK09392 391735014041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735014042 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These...; Region: MopB_3; cd02766 391735014043 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 391735014044 putative [4Fe-4S] binding site [ion binding]; other site 391735014045 putative molybdopterin cofactor binding site [chemical binding]; other site 391735014046 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 391735014047 putative molybdopterin cofactor binding site; other site 391735014048 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735014049 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 391735014050 putative ligand binding site [chemical binding]; other site 391735014051 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735014052 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735014053 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735014054 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391735014055 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 391735014056 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391735014057 metal binding site [ion binding]; metal-binding site 391735014058 putative dimer interface [polypeptide binding]; other site 391735014059 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 391735014060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 391735014061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 391735014062 motif II; other site 391735014063 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 391735014064 Integrase core domain; Region: rve; cl01316 391735014065 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 391735014066 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 391735014067 superoxide dismutase; Provisional; Region: PRK10543 391735014068 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 391735014069 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 391735014070 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 391735014071 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 391735014072 generic binding surface II; other site 391735014073 generic binding surface I; other site 391735014074 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 391735014075 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 391735014076 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 391735014077 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 391735014078 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 391735014079 Trm112p-like protein; Region: Trm112p; cl01066 391735014080 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 391735014081 Ligand binding site [chemical binding]; other site 391735014082 oligomer interface [polypeptide binding]; other site 391735014083 adenylate kinase; Reviewed; Region: adk; PRK00279 391735014084 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 391735014085 AMP-binding site [chemical binding]; other site 391735014086 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 391735014087 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 391735014088 active site/substrate binding site [active] 391735014089 tetramer interface [polypeptide binding]; other site 391735014090 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 391735014091 Protein of unknown function (DUF433); Region: DUF433; cl01030 391735014092 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 391735014093 ANTAR domain; Region: ANTAR; pfam03861 391735014094 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735014095 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 391735014096 ligand binding site [chemical binding]; other site 391735014097 regulator interaction site; other site 391735014098 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 391735014099 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 391735014100 metal ion-dependent adhesion site (MIDAS); other site 391735014101 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 391735014102 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 391735014103 Walker A motif; other site 391735014104 ATP binding site [chemical binding]; other site 391735014105 Walker B motif; other site 391735014106 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 391735014107 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 391735014108 Predicted amidohydrolase [General function prediction only]; Region: COG0388 391735014109 multimer interface [polypeptide binding]; other site 391735014110 active site 391735014111 catalytic triad [active] 391735014112 dimer interface [polypeptide binding]; other site 391735014113 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 391735014114 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 391735014115 Walker A/P-loop; other site 391735014116 ATP binding site [chemical binding]; other site 391735014117 Q-loop/lid; other site 391735014118 ABC transporter signature motif; other site 391735014119 Walker B; other site 391735014120 D-loop; other site 391735014121 H-loop/switch region; other site 391735014122 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 391735014123 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 391735014124 Walker A/P-loop; other site 391735014125 ATP binding site [chemical binding]; other site 391735014126 Q-loop/lid; other site 391735014127 ABC transporter signature motif; other site 391735014128 Walker B; other site 391735014129 D-loop; other site 391735014130 H-loop/switch region; other site 391735014131 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391735014132 TM-ABC transporter signature motif; other site 391735014133 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391735014134 TM-ABC transporter signature motif; other site 391735014135 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735014136 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 391735014137 putative ligand binding site [chemical binding]; other site 391735014138 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 391735014139 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391735014140 tetramer interface [polypeptide binding]; other site 391735014141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735014142 catalytic residue [active] 391735014143 LexA repressor; Validated; Region: PRK00215 391735014144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735014145 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 391735014146 Catalytic site [active] 391735014147 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 391735014148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735014149 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735014150 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 391735014151 dimerization interface [polypeptide binding]; other site 391735014152 ligand binding site [chemical binding]; other site 391735014153 formate dehydrogenase; Provisional; Region: PRK07574 391735014154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735014155 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391735014156 non-specific DNA binding site [nucleotide binding]; other site 391735014157 salt bridge; other site 391735014158 sequence-specific DNA binding site [nucleotide binding]; other site 391735014159 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391735014160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735014161 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391735014162 dimerization interface [polypeptide binding]; other site 391735014163 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391735014164 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 391735014165 dimerization interface [polypeptide binding]; other site 391735014166 ligand binding site [chemical binding]; other site 391735014167 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 391735014168 multifunctional aminopeptidase A; Provisional; Region: PRK00913 391735014169 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 391735014170 interface (dimer of trimers) [polypeptide binding]; other site 391735014171 Substrate-binding/catalytic site; other site 391735014172 Zn-binding sites [ion binding]; other site 391735014173 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 391735014174 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 391735014175 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 391735014176 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 391735014177 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 391735014178 putative active site [active] 391735014179 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 391735014180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735014181 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 391735014182 substrate binding site [chemical binding]; other site 391735014183 dimerization interface [polypeptide binding]; other site 391735014184 methionine aminotransferase; Validated; Region: PRK09082 391735014185 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391735014186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391735014187 homodimer interface [polypeptide binding]; other site 391735014188 catalytic residue [active] 391735014189 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 391735014190 putative metal binding site [ion binding]; other site 391735014191 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391735014192 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 391735014193 C-terminal domain interface [polypeptide binding]; other site 391735014194 GSH binding site (G-site) [chemical binding]; other site 391735014195 dimer interface [polypeptide binding]; other site 391735014196 Glutathione S-transferase (GST) family, C-terminal alpha helical domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and...; Region: GST_C_family; cd00299 391735014197 N-terminal domain interface [polypeptide binding]; other site 391735014198 dimer interface [polypeptide binding]; other site 391735014199 substrate binding pocket (H-site) [chemical binding]; other site 391735014200 Protein of unknown function (DUF461); Region: DUF461; cl01071 391735014201 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 391735014202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 391735014203 FIST N domain; Region: FIST; pfam08495 391735014204 FIST C domain; Region: FIST_C; pfam10442 391735014205 Domain of unknown function DUF21; Region: DUF21; pfam01595 391735014206 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 391735014207 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 391735014208 Transporter associated domain; Region: CorC_HlyC; pfam03471 391735014209 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 391735014210 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 391735014211 active site 391735014212 HIGH motif; other site 391735014213 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 391735014214 KMSKS motif; other site 391735014215 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 391735014216 tRNA binding surface [nucleotide binding]; other site 391735014217 anticodon binding site; other site 391735014218 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391735014219 endonuclease III; Region: ENDO3c; smart00478 391735014220 minor groove reading motif; other site 391735014221 helix-hairpin-helix signature motif; other site 391735014222 substrate binding pocket [chemical binding]; other site 391735014223 active site 391735014224 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 391735014225 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 391735014226 TilS substrate binding domain; Region: TilS; pfam09179 391735014227 aspartate kinase; Reviewed; Region: PRK06635 391735014228 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 391735014229 putative nucleotide binding site [chemical binding]; other site 391735014230 putative catalytic residues [active] 391735014231 putative Mg ion binding site [ion binding]; other site 391735014232 putative aspartate binding site [chemical binding]; other site 391735014233 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 391735014234 putative allosteric regulatory site; other site 391735014235 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 391735014236 HipA-like N-terminal domain; Region: HipA_N; pfam07805 391735014237 HipA-like C-terminal domain; Region: HipA_C; pfam07804 391735014238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391735014239 non-specific DNA binding site [nucleotide binding]; other site 391735014240 salt bridge; other site 391735014241 sequence-specific DNA binding site [nucleotide binding]; other site 391735014242 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; cl09893 391735014243 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 391735014244 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 391735014245 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 391735014246 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 391735014247 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391735014248 NAD binding site [chemical binding]; other site 391735014249 catalytic residues [active] 391735014250 substrate binding site [chemical binding]; other site 391735014251 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 391735014252 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 391735014253 iron-sulfur cluster [ion binding]; other site 391735014254 [2Fe-2S] cluster binding site [ion binding]; other site 391735014255 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 391735014256 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 391735014257 Trp docking motif; other site 391735014258 'Velcro' closure; other site 391735014259 active site 391735014260 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 391735014261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 391735014262 Walker A motif; other site 391735014263 ATP binding site [chemical binding]; other site 391735014264 Walker B motif; other site 391735014265 arginine finger; other site 391735014266 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 391735014267 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 391735014268 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391735014269 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391735014270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391735014271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735014272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391735014273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391735014274 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 391735014275 trimer interface [polypeptide binding]; other site 391735014276 eyelet of channel; other site 391735014277 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 391735014278 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 391735014279 active site 391735014280 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 391735014281 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391735014282 active site 391735014283 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 391735014284 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 391735014285 substrate binding site [chemical binding]; other site 391735014286 oxyanion hole (OAH) forming residues; other site 391735014287 trimer interface [polypeptide binding]; other site 391735014288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391735014289 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391735014290 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391735014291 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 391735014292 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391735014293 dimer interface [polypeptide binding]; other site 391735014294 active site 391735014295 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 391735014296 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 391735014297 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391735014298 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735014299 Walker A/P-loop; other site 391735014300 ATP binding site [chemical binding]; other site 391735014301 Q-loop/lid; other site 391735014302 ABC transporter signature motif; other site 391735014303 Walker B; other site 391735014304 D-loop; other site 391735014305 H-loop/switch region; other site 391735014306 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735014307 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391735014308 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 391735014309 Walker A/P-loop; other site 391735014310 ATP binding site [chemical binding]; other site 391735014311 Q-loop/lid; other site 391735014312 ABC transporter signature motif; other site 391735014313 Walker B; other site 391735014314 D-loop; other site 391735014315 H-loop/switch region; other site 391735014316 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391735014317 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 391735014318 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391735014319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735014320 dimer interface [polypeptide binding]; other site 391735014321 conserved gate region; other site 391735014322 putative PBP binding loops; other site 391735014323 ABC-ATPase subunit interface; other site 391735014324 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391735014325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 391735014326 dimer interface [polypeptide binding]; other site 391735014327 conserved gate region; other site 391735014328 putative PBP binding loops; other site 391735014329 ABC-ATPase subunit interface; other site 391735014330 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 391735014331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391735014332 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 391735014333 substrate binding site [chemical binding]; other site 391735014334 Protein of unknown function (DUF521); Region: DUF521; pfam04412 391735014335 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 391735014336 substrate binding site [chemical binding]; other site 391735014337 ligand binding site [chemical binding]; other site 391735014338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391735014339 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735014340 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 391735014341 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 391735014342 Trp docking motif; other site 391735014343 'Velcro' closure; other site 391735014344 active site 391735014345 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 391735014346 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735014347 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 391735014348 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 391735014349 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 391735014350 Walker A/P-loop; other site 391735014351 ATP binding site [chemical binding]; other site 391735014352 Q-loop/lid; other site 391735014353 ABC transporter signature motif; other site 391735014354 Walker B; other site 391735014355 D-loop; other site 391735014356 H-loop/switch region; other site 391735014357 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 391735014358 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 391735014359 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 391735014360 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 391735014361 ligand binding site [chemical binding]; other site 391735014362 ABC-2 type transporter; Region: ABC2_membrane; cl11417 391735014363 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391735014364 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 391735014365 active site 391735014366 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 391735014367 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 391735014368 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 391735014369 Cytochrome c; Region: Cytochrom_C; cl11414 391735014370 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 391735014371 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391735014372 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 391735014373 Ligand Binding Site [chemical binding]; other site 391735014374 CreA protein; Region: CreA; cl01154 391735014375 cyanophycin synthetase; Provisional; Region: PRK14016 391735014376 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735014377 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391735014378 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391735014379 cyanophycin synthetase; Provisional; Region: PRK14016 391735014380 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 391735014381 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 391735014382 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 391735014383 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 391735014384 Walker A/P-loop; other site 391735014385 ATP binding site [chemical binding]; other site 391735014386 Q-loop/lid; other site 391735014387 ABC transporter signature motif; other site 391735014388 Walker B; other site 391735014389 D-loop; other site 391735014390 H-loop/switch region; other site 391735014391 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 391735014392 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 391735014393 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735014394 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 391735014395 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 391735014396 RelB antitoxin; Region: RelB; cl01171 391735014397 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 391735014398 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 391735014399 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 391735014400 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391735014401 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 391735014402 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391735014403 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 391735014404 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391735014405 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 391735014406 Walker A/P-loop; other site 391735014407 ATP binding site [chemical binding]; other site 391735014408 Q-loop/lid; other site 391735014409 ABC transporter signature motif; other site 391735014410 Walker B; other site 391735014411 D-loop; other site 391735014412 H-loop/switch region; other site 391735014413 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 391735014414 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391735014415 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391735014416 TM-ABC transporter signature motif; other site 391735014417 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391735014418 TM-ABC transporter signature motif; other site 391735014419 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 391735014420 putative ligand binding site [chemical binding]; other site 391735014421 ribonucleotide reductase-like protein; Provisional; Region: PRK06948 391735014422 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 391735014423 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 391735014424 active site 391735014425 dimer interface [polypeptide binding]; other site 391735014426 effector binding site; other site 391735014427 Flavin Reductases; Region: FlaRed; cl00801 391735014428 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 391735014429 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 391735014430 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 391735014431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 391735014432 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391735014433 dimerization interface [polypeptide binding]; other site 391735014434 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 391735014435 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 391735014436 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 391735014437 G1 box; other site 391735014438 GTP/Mg2+ binding site [chemical binding]; other site 391735014439 Switch I region; other site 391735014440 G2 box; other site 391735014441 Switch II region; other site 391735014442 G3 box; other site 391735014443 G4 box; other site 391735014444 G5 box; other site 391735014445 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 391735014446 membrane protein insertase; Provisional; Region: PRK01318 391735014447 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 391735014448 Domain of unknown function DUF37; Region: DUF37; cl00506 391735014449 Ribonuclease P; Region: Ribonuclease_P; cl00457 391735014450 Ribosomal protein L34; Region: Ribosomal_L34; cl00370