-- dump date 20111121_015623 -- class Genbank::misc_feature -- table misc_feature_note -- id note 150340000001 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 150340000002 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 150340000003 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 150340000004 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340000005 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 150340000006 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 150340000007 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 150340000008 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 150340000009 active site 150340000010 NTP binding site [chemical binding]; other site 150340000011 metal binding triad [ion binding]; metal-binding site 150340000012 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 150340000013 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 150340000014 Zn2+ binding site [ion binding]; other site 150340000015 Mg2+ binding site [ion binding]; other site 150340000016 Bacitracin resistance protein BacA; Region: BacA; cl00858 150340000017 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 150340000018 catalytic center binding site [active] 150340000019 ATP binding site [chemical binding]; other site 150340000020 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 150340000021 homooctamer interface [polypeptide binding]; other site 150340000022 active site 150340000023 Domain of unknown function (DUF205); Region: DUF205; cl00410 150340000024 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 150340000025 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 150340000026 UGMP family protein; Validated; Region: PRK09604 150340000027 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 150340000028 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 150340000029 GatB domain; Region: GatB_Yqey; cl11497 150340000030 DNA primase; Validated; Region: dnaG; PRK05667 150340000031 CHC2 zinc finger; Region: zf-CHC2; cl02597 150340000032 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 150340000033 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 150340000034 active site 150340000035 metal binding site [ion binding]; metal-binding site 150340000036 interdomain interaction site; other site 150340000037 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 150340000038 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 150340000039 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 150340000040 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 150340000041 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 150340000042 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 150340000043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 150340000044 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 150340000045 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 150340000046 DNA binding residues [nucleotide binding] 150340000047 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 150340000048 Protein of unknown function (DUF541); Region: SIMPL; cl01077 150340000049 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 150340000050 putative acyl-acceptor binding pocket; other site 150340000051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340000052 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 150340000053 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340000054 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_mannitol; cd05567 150340000055 active site 150340000056 P-loop; other site 150340000057 phosphorylation site [posttranslational modification] 150340000058 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 150340000059 active site 150340000060 phosphorylation site [posttranslational modification] 150340000061 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 150340000062 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 150340000063 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 150340000064 Mannitol repressor; Region: MtlR; cl11450 150340000065 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 150340000066 GAF domain; Region: GAF; cl00853 150340000067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340000068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340000069 Walker A motif; other site 150340000070 ATP binding site [chemical binding]; other site 150340000071 Walker B motif; other site 150340000072 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340000073 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 150340000074 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 150340000075 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 150340000076 dimerization domain swap beta strand [polypeptide binding]; other site 150340000077 regulatory protein interface [polypeptide binding]; other site 150340000078 active site 150340000079 regulatory phosphorylation site [posttranslational modification]; other site 150340000080 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 150340000081 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 150340000082 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 150340000083 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 150340000084 DAK2 domain; Region: Dak2; cl03685 150340000085 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 150340000086 Dak1 domain; Region: Dak1; pfam02733 150340000087 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 150340000088 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 150340000089 dimer interface [polypeptide binding]; other site 150340000090 active site 150340000091 metal binding site [ion binding]; metal-binding site 150340000092 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 150340000093 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340000094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340000095 dimer interface [polypeptide binding]; other site 150340000096 phosphorylation site [posttranslational modification] 150340000097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340000098 ATP binding site [chemical binding]; other site 150340000099 Mg2+ binding site [ion binding]; other site 150340000100 G-X-G motif; other site 150340000101 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 150340000102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340000103 active site 150340000104 phosphorylation site [posttranslational modification] 150340000105 intermolecular recognition site; other site 150340000106 dimerization interface [polypeptide binding]; other site 150340000107 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340000108 DNA binding site [nucleotide binding] 150340000109 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 150340000110 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 150340000111 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 150340000112 glutaminase active site [active] 150340000113 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 150340000114 dimer interface [polypeptide binding]; other site 150340000115 active site 150340000116 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 150340000117 dimer interface [polypeptide binding]; other site 150340000118 active site 150340000119 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 150340000120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340000121 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 150340000122 pyruvate kinase; Provisional; Region: PRK09206 150340000123 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 150340000124 domain interfaces; other site 150340000125 active site 150340000126 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 150340000127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340000128 DNA-binding site [nucleotide binding]; DNA binding site 150340000129 PAS domain S-box; Region: sensory_box; TIGR00229 150340000130 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340000131 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340000132 metal binding site [ion binding]; metal-binding site 150340000133 active site 150340000134 I-site; other site 150340000135 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 150340000136 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 150340000137 putative valine binding site [chemical binding]; other site 150340000138 dimer interface [polypeptide binding]; other site 150340000139 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 150340000140 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08979 150340000141 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 150340000142 PYR/PP interface [polypeptide binding]; other site 150340000143 dimer interface [polypeptide binding]; other site 150340000144 TPP binding site [chemical binding]; other site 150340000145 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 150340000146 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 150340000147 TPP-binding site [chemical binding]; other site 150340000148 dimer interface [polypeptide binding]; other site 150340000149 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 150340000150 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 150340000151 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 150340000152 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 150340000153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340000154 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 150340000155 putative substrate binding pocket [chemical binding]; other site 150340000156 putative dimerization interface [polypeptide binding]; other site 150340000157 conserved hypothetical protein; Region: MJ1255; TIGR00661 150340000158 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 150340000159 active site 150340000160 Bacterial SH3 domain; Region: SH3_3; cl02551 150340000161 2-isopropylmalate synthase; Validated; Region: PRK00915 150340000162 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 150340000163 active site 150340000164 catalytic residues [active] 150340000165 metal binding site [ion binding]; metal-binding site 150340000166 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 150340000167 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 150340000168 isocitrate dehydrogenase; Validated; Region: PRK06451 150340000169 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 150340000170 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 150340000171 substrate binding site [chemical binding]; other site 150340000172 ligand binding site [chemical binding]; other site 150340000173 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 150340000174 substrate binding site [chemical binding]; other site 150340000175 Protein of unknown function, DUF547; Region: DUF547; pfam04784 150340000176 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 150340000177 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 150340000178 putative metal binding site [ion binding]; other site 150340000179 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 150340000180 HSP70 interaction site [polypeptide binding]; other site 150340000181 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 150340000182 OstA-like protein; Region: OstA; cl00844 150340000183 Organic solvent tolerance protein; Region: OstA_C; pfam04453 150340000184 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 150340000185 SurA N-terminal domain; Region: SurA_N; pfam09312 150340000186 PPIC-type PPIASE domain; Region: Rotamase; cl08278 150340000187 PPIC-type PPIASE domain; Region: Rotamase; cl08278 150340000188 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 150340000189 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 150340000190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340000191 Protein of unknown function (DUF525); Region: DUF525; cl01119 150340000192 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 150340000193 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 150340000194 active site 150340000195 metal binding site [ion binding]; metal-binding site 150340000196 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209 150340000197 folate binding site [chemical binding]; other site 150340000198 NADP+ binding site [chemical binding]; other site 150340000199 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 150340000200 Uncharacterized conserved protein [Function unknown]; Region: COG2966 150340000201 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 150340000202 GTPase CgtA; Reviewed; Region: obgE; PRK12298 150340000203 GTP1/OBG; Region: GTP1_OBG; pfam01018 150340000204 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 150340000205 G1 box; other site 150340000206 GTP/Mg2+ binding site [chemical binding]; other site 150340000207 Switch I region; other site 150340000208 G2 box; other site 150340000209 G3 box; other site 150340000210 Switch II region; other site 150340000211 G4 box; other site 150340000212 G5 box; other site 150340000213 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 150340000214 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 150340000215 octaprenyl diphosphate synthase; Provisional; Region: PRK10888 150340000216 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 150340000217 substrate binding pocket [chemical binding]; other site 150340000218 chain length determination region; other site 150340000219 substrate-Mg2+ binding site; other site 150340000220 catalytic residues [active] 150340000221 aspartate-rich region 1; other site 150340000222 active site lid residues [active] 150340000223 aspartate-rich region 2; other site 150340000224 malate dehydrogenase; Provisional; Region: PRK05086 150340000225 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 150340000226 NAD binding site [chemical binding]; other site 150340000227 dimerization interface [polypeptide binding]; other site 150340000228 Substrate binding site [chemical binding]; other site 150340000229 arginine repressor; Provisional; Region: PRK05066 150340000230 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 150340000231 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 150340000232 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 150340000233 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 150340000234 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340000235 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340000236 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 150340000237 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 150340000238 Ligand Binding Site [chemical binding]; other site 150340000239 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 150340000240 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 150340000241 FMN binding site [chemical binding]; other site 150340000242 active site 150340000243 substrate binding site [chemical binding]; other site 150340000244 catalytic residue [active] 150340000245 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340000246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340000247 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340000248 putative effector binding pocket; other site 150340000249 dimerization interface [polypeptide binding]; other site 150340000250 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 150340000251 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340000252 Walker A/P-loop; other site 150340000253 ATP binding site [chemical binding]; other site 150340000254 Q-loop/lid; other site 150340000255 ABC transporter signature motif; other site 150340000256 Walker B; other site 150340000257 D-loop; other site 150340000258 H-loop/switch region; other site 150340000259 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 150340000260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340000261 dimer interface [polypeptide binding]; other site 150340000262 conserved gate region; other site 150340000263 putative PBP binding loops; other site 150340000264 ABC-ATPase subunit interface; other site 150340000265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340000266 dimer interface [polypeptide binding]; other site 150340000267 conserved gate region; other site 150340000268 putative PBP binding loops; other site 150340000269 ABC-ATPase subunit interface; other site 150340000270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340000271 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 150340000272 aromatic acid decarboxylase; Validated; Region: PRK05920 150340000273 Flavoprotein; Region: Flavoprotein; cl08021 150340000274 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 150340000275 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 150340000276 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 150340000277 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 150340000278 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1,7-...; Region: FBPase; cd00354 150340000279 AMP binding site [chemical binding]; other site 150340000280 metal binding site [ion binding]; metal-binding site 150340000281 active site 150340000282 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 150340000283 dimer interface [polypeptide binding]; other site 150340000284 substrate binding site [chemical binding]; other site 150340000285 metal binding sites [ion binding]; metal-binding site 150340000286 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 150340000287 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 150340000288 putative active site pocket [active] 150340000289 dimerization interface [polypeptide binding]; other site 150340000290 putative catalytic residue [active] 150340000291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 150340000292 Family of unknown function (DUF490); Region: DUF490; pfam04357 150340000293 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 150340000294 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 150340000295 Surface antigen; Region: Bac_surface_Ag; cl03097 150340000296 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 150340000297 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 150340000298 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl01158 150340000299 Protein of unknown function (DUF2607); Region: DUF2607; pfam10795 150340000300 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 150340000301 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 150340000302 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 150340000303 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 150340000304 Walker A/P-loop; other site 150340000305 ATP binding site [chemical binding]; other site 150340000306 Q-loop/lid; other site 150340000307 ABC transporter signature motif; other site 150340000308 Walker B; other site 150340000309 D-loop; other site 150340000310 H-loop/switch region; other site 150340000311 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 150340000312 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 150340000313 FtsX-like permease family; Region: FtsX; pfam02687 150340000314 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 150340000315 Protein of unknown function (DUF2806); Region: DUF2806; cl12560 150340000316 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 150340000317 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 150340000318 ligand-binding site [chemical binding]; other site 150340000319 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340000320 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340000321 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340000322 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340000323 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 150340000324 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 150340000325 CysD dimerization site [polypeptide binding]; other site 150340000326 G1 box; other site 150340000327 putative GEF interaction site [polypeptide binding]; other site 150340000328 GTP/Mg2+ binding site [chemical binding]; other site 150340000329 Switch I region; other site 150340000330 G2 box; other site 150340000331 G3 box; other site 150340000332 Switch II region; other site 150340000333 G4 box; other site 150340000334 G5 box; other site 150340000335 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 150340000336 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 150340000337 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 150340000338 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 150340000339 Active Sites [active] 150340000340 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 150340000341 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 150340000342 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 150340000343 active site 150340000344 metal binding site [ion binding]; metal-binding site 150340000345 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 150340000346 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 150340000347 ligand binding site [chemical binding]; other site 150340000348 flexible hinge region; other site 150340000349 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 150340000350 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 150340000351 ATP binding site [chemical binding]; other site 150340000352 Mg++ binding site [ion binding]; other site 150340000353 motif III; other site 150340000354 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340000355 nucleotide binding region [chemical binding]; other site 150340000356 ATP-binding site [chemical binding]; other site 150340000357 DbpA RNA binding domain; Region: DbpA; pfam03880 150340000358 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340000359 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 150340000360 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 150340000361 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 150340000362 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 150340000363 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 150340000364 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 150340000365 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 150340000366 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 150340000367 alphaNTD homodimer interface [polypeptide binding]; other site 150340000368 alphaNTD - beta interaction site [polypeptide binding]; other site 150340000369 alphaNTD - beta' interaction site [polypeptide binding]; other site 150340000370 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 150340000371 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 150340000372 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 150340000373 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 150340000374 RNA binding surface [nucleotide binding]; other site 150340000375 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 150340000376 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 150340000377 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 150340000378 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 150340000379 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 150340000380 SecY translocase; Region: SecY; pfam00344 150340000381 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 150340000382 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 150340000383 23S rRNA binding site [nucleotide binding]; other site 150340000384 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 150340000385 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 150340000386 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 150340000387 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 150340000388 5S rRNA interface [nucleotide binding]; other site 150340000389 23S rRNA interface [nucleotide binding]; other site 150340000390 L5 interface [polypeptide binding]; other site 150340000391 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 150340000392 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 150340000393 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 150340000394 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 150340000395 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 150340000396 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 150340000397 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 150340000398 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 150340000399 KOW motif; Region: KOW; cl00354 150340000400 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 150340000401 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 150340000402 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 150340000403 23S rRNA interface [nucleotide binding]; other site 150340000404 putative translocon interaction site; other site 150340000405 signal recognition particle (SRP54) interaction site; other site 150340000406 L23 interface [polypeptide binding]; other site 150340000407 trigger factor interaction site; other site 150340000408 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 150340000409 23S rRNA interface [nucleotide binding]; other site 150340000410 5S rRNA interface [nucleotide binding]; other site 150340000411 putative antibiotic binding site [chemical binding]; other site 150340000412 L25 interface [polypeptide binding]; other site 150340000413 L27 interface [polypeptide binding]; other site 150340000414 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 150340000415 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 150340000416 G-X-X-G motif; other site 150340000417 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 150340000418 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 150340000419 putative translocon binding site; other site 150340000420 protein-rRNA interface [nucleotide binding]; other site 150340000421 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 150340000422 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 150340000423 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 150340000424 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 150340000425 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 150340000426 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 150340000427 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 150340000428 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 150340000429 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 150340000430 primosome assembly protein PriA; Validated; Region: PRK05580 150340000431 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 150340000432 ATP binding site [chemical binding]; other site 150340000433 putative Mg++ binding site [ion binding]; other site 150340000434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340000435 nucleotide binding region [chemical binding]; other site 150340000436 ATP-binding site [chemical binding]; other site 150340000437 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 150340000438 DNA binding site [nucleotide binding] 150340000439 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 150340000440 domain linker motif; other site 150340000441 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 150340000442 dimerization interface [polypeptide binding]; other site 150340000443 ligand binding site [chemical binding]; other site 150340000444 Sporulation related domain; Region: SPOR; cl10051 150340000445 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 150340000446 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 150340000447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340000448 Walker A motif; other site 150340000449 ATP binding site [chemical binding]; other site 150340000450 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340000451 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 150340000452 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; COG1575 150340000453 UbiA prenyltransferase family; Region: UbiA; cl00337 150340000454 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 150340000455 Protein of unknown function (DUF904); Region: DUF904; cl11531 150340000456 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 150340000457 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 150340000458 putative active site [active] 150340000459 Predicted transcriptional regulator [Transcription]; Region: COG2345 150340000460 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340000461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340000462 Protein of unknown function (DUF3135); Region: DUF3135; pfam11333 150340000463 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 150340000464 catalytic site [active] 150340000465 metal binding site [ion binding]; metal-binding site 150340000466 Protein of unknown function (DUF805); Region: DUF805; cl01224 150340000467 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 150340000468 putative substrate binding pocket [chemical binding]; other site 150340000469 trimer interface [polypeptide binding]; other site 150340000470 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 150340000471 substrate binding site [chemical binding]; other site 150340000472 dimer interface [polypeptide binding]; other site 150340000473 catalytic triad [active] 150340000474 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 150340000475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340000476 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 150340000477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340000478 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 150340000479 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 150340000480 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 150340000481 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 150340000482 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 150340000483 NAD(P) binding site [chemical binding]; other site 150340000484 homodimer interface [polypeptide binding]; other site 150340000485 substrate binding site [chemical binding]; other site 150340000486 active site 150340000487 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 150340000488 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 150340000489 inhibitor-cofactor binding pocket; inhibition site 150340000490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340000491 catalytic residue [active] 150340000492 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 150340000493 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 150340000494 putative trimer interface [polypeptide binding]; other site 150340000495 putative CoA binding site [chemical binding]; other site 150340000496 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 150340000497 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 150340000498 putative ADP-binding pocket [chemical binding]; other site 150340000499 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 150340000500 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 150340000501 active site 150340000502 MatE; Region: MatE; cl10513 150340000503 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 150340000504 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 150340000505 NAD binding site [chemical binding]; other site 150340000506 substrate binding site [chemical binding]; other site 150340000507 homodimer interface [polypeptide binding]; other site 150340000508 active site 150340000509 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 150340000510 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 150340000511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340000512 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 150340000513 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 150340000514 Beta-Casp domain; Region: Beta-Casp; cl12567 150340000515 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 150340000516 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 150340000517 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 150340000518 Mg++ binding site [ion binding]; other site 150340000519 putative catalytic motif [active] 150340000520 substrate binding site [chemical binding]; other site 150340000521 NeuB family; Region: NeuB; cl00496 150340000522 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 150340000523 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 150340000524 Ligand binding site [chemical binding]; other site 150340000525 oligomer interface [polypeptide binding]; other site 150340000526 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 150340000527 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 150340000528 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 150340000529 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 150340000530 Vi polysaccharide export inner membrane protein VexD; Provisional; Region: PRK15178 150340000531 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 150340000532 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 150340000533 Walker A/P-loop; other site 150340000534 ATP binding site [chemical binding]; other site 150340000535 Q-loop/lid; other site 150340000536 ABC transporter signature motif; other site 150340000537 Walker B; other site 150340000538 D-loop; other site 150340000539 H-loop/switch region; other site 150340000540 ABC-2 type transporter; Region: ABC2_membrane; cl11417 150340000541 KpsF/GutQ family protein; Region: kpsF; TIGR00393 150340000542 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 150340000543 putative active site [active] 150340000544 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 150340000545 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 150340000546 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 150340000547 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 150340000548 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 150340000549 SLBB-domain like (DUF1017); Region: DUF1017; pfam06251 150340000550 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 150340000551 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 150340000552 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 150340000553 NADP binding site [chemical binding]; other site 150340000554 homopentamer interface [polypeptide binding]; other site 150340000555 substrate binding site [chemical binding]; other site 150340000556 active site 150340000557 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 150340000558 putative acyl-acceptor binding pocket; other site 150340000559 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 150340000560 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 150340000561 putative active site [active] 150340000562 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 150340000563 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 150340000564 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 150340000565 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 150340000566 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 150340000567 ligand binding site [chemical binding]; other site 150340000568 tetramer interface [polypeptide binding]; other site 150340000569 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 150340000570 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 150340000571 Substrate binding site [chemical binding]; other site 150340000572 metal binding site [ion binding]; metal-binding site 150340000573 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 150340000574 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 150340000575 putative trimer interface [polypeptide binding]; other site 150340000576 putative CoA binding site [chemical binding]; other site 150340000577 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 150340000578 NeuB family; Region: NeuB; cl00496 150340000579 SAF domain; Region: SAF; cl00555 150340000580 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 150340000581 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 150340000582 active site 150340000583 homodimer interface [polypeptide binding]; other site 150340000584 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 150340000585 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 150340000586 inhibitor-cofactor binding pocket; inhibition site 150340000587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340000588 catalytic residue [active] 150340000589 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 150340000590 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 150340000591 NAD(P) binding site [chemical binding]; other site 150340000592 homodimer interface [polypeptide binding]; other site 150340000593 substrate binding site [chemical binding]; other site 150340000594 active site 150340000595 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 150340000596 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 150340000597 inhibitor-cofactor binding pocket; inhibition site 150340000598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340000599 catalytic residue [active] 150340000600 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 150340000601 active site 150340000602 cosubstrate binding site; other site 150340000603 substrate binding site [chemical binding]; other site 150340000604 catalytic site [active] 150340000605 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cd08370 150340000606 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 150340000607 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 150340000608 substrate binding site [chemical binding]; other site 150340000609 tetramer interface [polypeptide binding]; other site 150340000610 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 150340000611 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 150340000612 NAD binding site [chemical binding]; other site 150340000613 substrate binding site [chemical binding]; other site 150340000614 homodimer interface [polypeptide binding]; other site 150340000615 active site 150340000616 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 150340000617 ATP binding site [chemical binding]; other site 150340000618 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 150340000619 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 150340000620 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 150340000621 putative active site [active] 150340000622 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 150340000623 putative metal binding site [ion binding]; other site 150340000624 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 150340000625 Substrate binding site [chemical binding]; other site 150340000626 metal binding site [ion binding]; metal-binding site 150340000627 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 150340000628 active site 150340000629 (T/H)XGH motif; other site 150340000630 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 150340000631 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 150340000632 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 150340000633 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 150340000634 DNA binding site [nucleotide binding] 150340000635 catalytic residue [active] 150340000636 H2TH interface [polypeptide binding]; other site 150340000637 putative catalytic residues [active] 150340000638 turnover-facilitating residue; other site 150340000639 intercalation triad [nucleotide binding]; other site 150340000640 8OG recognition residue [nucleotide binding]; other site 150340000641 putative reading head residues; other site 150340000642 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 150340000643 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 150340000644 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 150340000645 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 150340000646 hypothetical protein; Reviewed; Region: PRK00024 150340000647 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 150340000648 MPN+ (JAMM) motif; other site 150340000649 Zinc-binding site [ion binding]; other site 150340000650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 150340000651 Cache domain; Region: Cache_2; cl07034 150340000652 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 150340000653 dimerization interface [polypeptide binding]; other site 150340000654 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340000655 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340000656 phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, prokaryotic; Region: coaBC_dfp; TIGR00521 150340000657 Flavoprotein; Region: Flavoprotein; cl08021 150340000658 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 150340000659 division inhibitor protein; Provisional; Region: slmA; PRK09480 150340000660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 150340000661 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 150340000662 putative acyl-acceptor binding pocket; other site 150340000663 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 150340000664 ribonuclease PH; Reviewed; Region: rph; PRK00173 150340000665 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 150340000666 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 150340000667 hypothetical protein; Provisional; Region: PRK11820 150340000668 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 150340000669 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 150340000670 integrase; Provisional; Region: PRK09692 150340000671 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 150340000672 active site 150340000673 Int/Topo IB signature motif; other site 150340000674 Uncharacterized conserved protein [Function unknown]; Region: COG4938 150340000675 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340000676 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340000677 Walker B; other site 150340000678 D-loop; other site 150340000679 H-loop/switch region; other site 150340000680 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 150340000681 Protein of unknown function DUF262; Region: DUF262; cl14890 150340000682 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 150340000683 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 150340000684 cofactor binding site; other site 150340000685 DNA binding site [nucleotide binding] 150340000686 substrate interaction site [chemical binding]; other site 150340000687 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 150340000688 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 150340000689 active site 150340000690 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 150340000691 MPN+ (JAMM) motif; other site 150340000692 Zinc-binding site [ion binding]; other site 150340000693 Protein of unknown function (DUF2787); Region: DUF2787; pfam10980 150340000694 Protein of unknown function (DUF2787); Region: DUF2787; pfam10980 150340000695 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 150340000696 DNA binding site [nucleotide binding] 150340000697 Int/Topo IB signature motif; other site 150340000698 active site 150340000699 NC domain; Region: NC; pfam04970 150340000700 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 150340000701 tellurium resistance terB-like protein; Region: terB_like; cl11965 150340000702 metal binding site [ion binding]; metal-binding site 150340000703 Predicted transcriptional regulator [Transcription]; Region: COG2378 150340000704 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340000705 metal binding site [ion binding]; metal-binding site 150340000706 active site 150340000707 I-site; other site 150340000708 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 150340000709 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340000710 Walker A/P-loop; other site 150340000711 ATP binding site [chemical binding]; other site 150340000712 Q-loop/lid; other site 150340000713 ABC transporter signature motif; other site 150340000714 Walker B; other site 150340000715 D-loop; other site 150340000716 H-loop/switch region; other site 150340000717 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 150340000718 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340000719 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 150340000720 Walker A/P-loop; other site 150340000721 ATP binding site [chemical binding]; other site 150340000722 Q-loop/lid; other site 150340000723 ABC transporter signature motif; other site 150340000724 Walker B; other site 150340000725 D-loop; other site 150340000726 H-loop/switch region; other site 150340000727 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 150340000728 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 150340000729 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 150340000730 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 150340000731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340000732 dimer interface [polypeptide binding]; other site 150340000733 conserved gate region; other site 150340000734 putative PBP binding loops; other site 150340000735 ABC-ATPase subunit interface; other site 150340000736 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 150340000737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340000738 dimer interface [polypeptide binding]; other site 150340000739 conserved gate region; other site 150340000740 putative PBP binding loops; other site 150340000741 ABC-ATPase subunit interface; other site 150340000742 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 150340000743 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 150340000744 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 150340000745 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 150340000746 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 150340000747 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 150340000748 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 150340000749 Gram-negative bacterial tonB protein; Region: TonB; cl10048 150340000750 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 150340000751 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 150340000752 catalytic site [active] 150340000753 G-X2-G-X-G-K; other site 150340000754 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 150340000755 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 150340000756 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 150340000757 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 150340000758 synthetase active site [active] 150340000759 NTP binding site [chemical binding]; other site 150340000760 metal binding site [ion binding]; metal-binding site 150340000761 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 150340000762 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 150340000763 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 150340000764 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 150340000765 C-terminal; Region: SpoU_methylas_C; pfam12105 150340000766 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 150340000767 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 150340000768 ssDNA binding site; other site 150340000769 generic binding surface II; other site 150340000770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 150340000771 ATP binding site [chemical binding]; other site 150340000772 putative Mg++ binding site [ion binding]; other site 150340000773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340000774 nucleotide binding region [chemical binding]; other site 150340000775 ATP-binding site [chemical binding]; other site 150340000776 Permease family; Region: Xan_ur_permease; pfam00860 150340000777 Sulfate transporter family; Region: Sulfate_transp; cl00967 150340000778 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 150340000779 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340000780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340000781 dimer interface [polypeptide binding]; other site 150340000782 phosphorylation site [posttranslational modification] 150340000783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340000784 ATP binding site [chemical binding]; other site 150340000785 Mg2+ binding site [ion binding]; other site 150340000786 G-X-G motif; other site 150340000787 osmolarity response regulator; Provisional; Region: ompR; PRK09468 150340000788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340000789 active site 150340000790 phosphorylation site [posttranslational modification] 150340000791 intermolecular recognition site; other site 150340000792 dimerization interface [polypeptide binding]; other site 150340000793 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340000794 DNA binding site [nucleotide binding] 150340000795 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 150340000796 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 150340000797 domain; Region: GreA_GreB_N; pfam03449 150340000798 C-term; Region: GreA_GreB; pfam01272 150340000799 Protein of unknown function (DUF785); Region: DUF785; cl01682 150340000800 Protein of unknown function (DUF785); Region: DUF785; cl01682 150340000801 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 150340000802 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 150340000803 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 150340000804 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 150340000805 RNA binding site [nucleotide binding]; other site 150340000806 putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738 150340000807 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 150340000808 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 150340000809 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 150340000810 NifU-like domain; Region: NifU; cl00484 150340000811 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 150340000812 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 150340000813 dimer interface [polypeptide binding]; other site 150340000814 ADP-ribose binding site [chemical binding]; other site 150340000815 active site 150340000816 nudix motif; other site 150340000817 metal binding site [ion binding]; metal-binding site 150340000818 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 150340000819 active site 150340000820 Bacterial type II secretion system protein N; Region: GSPII_N; pfam01203 150340000821 General secretion pathway, M protein; Region: GspM; cl01222 150340000822 general secretion pathway protein L; Region: typeII_sec_gspL; TIGR01709 150340000823 GspL cytoplasmic actin-ATPase-like region; Region: GspL; pfam05134 150340000824 GspL periplasmic domain; Region: GspL_C; cl14909 150340000825 General secretion pathway protein K; Region: GspK; pfam03934 150340000826 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 150340000827 general secretion pathway protein J; Region: gspJ; TIGR01711 150340000828 Pseudopilin GspJ; Region: GspJ; pfam11612 150340000829 general secretion pathway protein I; Region: gspI; TIGR01707 150340000830 Bacterial type II secretion system protein I/J; Region: GSPII_IJ; pfam02501 150340000831 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 150340000832 general secretion pathway protein G; Region: typeII_sec_gspG; TIGR01710 150340000833 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 150340000834 general secretion pathway protein F; Region: GspF; TIGR02120 150340000835 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 150340000836 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 150340000837 general secretory pathway protein E; Region: type_II_gspE; TIGR02533 150340000838 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 150340000839 Walker A motif; other site 150340000840 ATP binding site [chemical binding]; other site 150340000841 Walker B motif; other site 150340000842 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 150340000843 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 150340000844 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 150340000845 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 150340000846 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 150340000847 general secretion pathway protein C; Region: typeII_sec_gspC; TIGR01713 150340000848 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 150340000849 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 150340000850 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 150340000851 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 150340000852 dimerization interface [polypeptide binding]; other site 150340000853 domain crossover interface; other site 150340000854 redox-dependent activation switch; other site 150340000855 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 150340000856 active site 150340000857 substrate-binding site [chemical binding]; other site 150340000858 metal-binding site [ion binding] 150340000859 ATP binding site [chemical binding]; other site 150340000860 AsmA family; Region: AsmA; pfam05170 150340000861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340000862 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 150340000863 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 150340000864 putative active site [active] 150340000865 dimerization interface [polypeptide binding]; other site 150340000866 putative tRNAtyr binding site [nucleotide binding]; other site 150340000867 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 150340000868 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 150340000869 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; cl01238 150340000870 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 150340000871 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 150340000872 G1 box; other site 150340000873 putative GEF interaction site [polypeptide binding]; other site 150340000874 GTP/Mg2+ binding site [chemical binding]; other site 150340000875 Switch I region; other site 150340000876 G2 box; other site 150340000877 G3 box; other site 150340000878 Switch II region; other site 150340000879 G4 box; other site 150340000880 G5 box; other site 150340000881 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 150340000882 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 150340000883 glutamine synthetase; Provisional; Region: glnA; PRK09469 150340000884 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 150340000885 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 150340000886 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 150340000887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340000888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 150340000889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340000890 ATP binding site [chemical binding]; other site 150340000891 Mg2+ binding site [ion binding]; other site 150340000892 G-X-G motif; other site 150340000893 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 150340000894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340000895 active site 150340000896 phosphorylation site [posttranslational modification] 150340000897 intermolecular recognition site; other site 150340000898 dimerization interface [polypeptide binding]; other site 150340000899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340000900 Walker A motif; other site 150340000901 ATP binding site [chemical binding]; other site 150340000902 Walker B motif; other site 150340000903 arginine finger; other site 150340000904 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340000905 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 150340000906 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340000907 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340000908 metal binding site [ion binding]; metal-binding site 150340000909 active site 150340000910 I-site; other site 150340000911 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340000912 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 150340000913 active site 150340000914 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 150340000915 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 150340000916 FeS/SAM binding site; other site 150340000917 HemN C-terminal region; Region: HemN_C; pfam06969 150340000918 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 150340000919 Protein of unknown function, DUF414; Region: DUF414; cl01172 150340000920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340000921 Cytochrome c; Region: Cytochrom_C; cl11414 150340000922 Cytochrome c; Region: Cytochrom_C; cl11414 150340000923 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 150340000924 G1 box; other site 150340000925 GTP/Mg2+ binding site [chemical binding]; other site 150340000926 Switch I region; other site 150340000927 G2 box; other site 150340000928 G3 box; other site 150340000929 Switch II region; other site 150340000930 G4 box; other site 150340000931 G5 box; other site 150340000932 DNA polymerase I; Provisional; Region: PRK05755 150340000933 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 150340000934 active site 150340000935 metal binding site 1 [ion binding]; metal-binding site 150340000936 putative 5' ssDNA interaction site; other site 150340000937 metal binding site 3; metal-binding site 150340000938 metal binding site 2 [ion binding]; metal-binding site 150340000939 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 150340000940 putative DNA binding site [nucleotide binding]; other site 150340000941 putative metal binding site [ion binding]; other site 150340000942 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 150340000943 active site 150340000944 catalytic site [active] 150340000945 substrate binding site [chemical binding]; other site 150340000946 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 150340000947 active site 150340000948 DNA binding site [nucleotide binding] 150340000949 catalytic site [active] 150340000950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340000951 Coenzyme A binding pocket [chemical binding]; other site 150340000952 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 150340000953 dimer interface [polypeptide binding]; other site 150340000954 allosteric magnesium binding site [ion binding]; other site 150340000955 active site 150340000956 aspartate-rich active site metal binding site; other site 150340000957 Schiff base residues; other site 150340000958 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 150340000959 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 150340000960 active site 150340000961 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 150340000962 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 150340000963 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 150340000964 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 150340000965 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 150340000966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 150340000967 SCP-2 sterol transfer family; Region: SCP2; cl01225 150340000968 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 150340000969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340000970 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 150340000971 RmuC family; Region: RmuC; pfam02646 150340000972 EamA-like transporter family; Region: EamA; cl01037 150340000973 EamA-like transporter family; Region: EamA; cl01037 150340000974 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 150340000975 PAS domain S-box; Region: sensory_box; TIGR00229 150340000976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 150340000977 putative active site [active] 150340000978 heme pocket [chemical binding]; other site 150340000979 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340000980 metal binding site [ion binding]; metal-binding site 150340000981 active site 150340000982 I-site; other site 150340000983 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340000984 Domain of unknown function DUF20; Region: UPF0118; cl00465 150340000985 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 150340000986 hypothetical protein; Provisional; Region: PRK12361 150340000987 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 150340000988 active site 150340000989 catalytic residues [active] 150340000990 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 150340000991 BON domain; Region: BON; cl02771 150340000992 BON domain; Region: BON; cl02771 150340000993 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 150340000994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340000995 Walker A motif; other site 150340000996 ATP binding site [chemical binding]; other site 150340000997 Walker B motif; other site 150340000998 arginine finger; other site 150340000999 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340001000 Predicted flavoproteins [General function prediction only]; Region: COG2081 150340001001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340001002 Universal stress protein B (UspB); Region: UspB; cl11669 150340001003 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 150340001004 Ferritin-like domain; Region: Ferritin; pfam00210 150340001005 ferroxidase diiron center [ion binding]; other site 150340001006 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 150340001007 Ligand Binding Site [chemical binding]; other site 150340001008 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 150340001009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340001010 PAS domain S-box; Region: sensory_box; TIGR00229 150340001011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 150340001012 putative active site [active] 150340001013 heme pocket [chemical binding]; other site 150340001014 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340001015 metal binding site [ion binding]; metal-binding site 150340001016 active site 150340001017 I-site; other site 150340001018 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340001019 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 150340001020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340001021 oligopeptidase A; Provisional; Region: PRK10911 150340001022 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 150340001023 active site 150340001024 Zn binding site [ion binding]; other site 150340001025 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 150340001026 glutathione reductase; Validated; Region: PRK06116 150340001027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340001028 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 150340001029 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 150340001030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340001031 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 150340001032 putative dimerization interface [polypeptide binding]; other site 150340001033 putative substrate binding pocket [chemical binding]; other site 150340001034 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 150340001035 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 150340001036 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 150340001037 active site 150340001038 intersubunit interface [polypeptide binding]; other site 150340001039 catalytic residue [active] 150340001040 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 150340001041 GntP family permease; Region: GntP_permease; cl15264 150340001042 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 150340001043 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 150340001044 ATP-binding site [chemical binding]; other site 150340001045 Gluconate-6-phosphate binding site [chemical binding]; other site 150340001046 Dehydratase family; Region: ILVD_EDD; cl00340 150340001047 6-phosphogluconate dehydratase; Region: edd; TIGR01196 150340001048 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 150340001049 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 150340001050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340001051 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340001052 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 150340001053 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 150340001054 DNA binding site [nucleotide binding] 150340001055 domain linker motif; other site 150340001056 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 150340001057 putative ligand binding site [chemical binding]; other site 150340001058 putative dimerization interface [polypeptide binding]; other site 150340001059 Catalytic domain of Protein Kinases; Region: PKc; cd00180 150340001060 active site 150340001061 ATP binding site [chemical binding]; other site 150340001062 substrate binding site [chemical binding]; other site 150340001063 activation loop (A-loop); other site 150340001064 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 150340001065 Sporulation related domain; Region: SPOR; cl10051 150340001066 dipeptide transporter; Provisional; Region: PRK10913 150340001067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340001068 dimer interface [polypeptide binding]; other site 150340001069 conserved gate region; other site 150340001070 putative PBP binding loops; other site 150340001071 ABC-ATPase subunit interface; other site 150340001072 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 150340001073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340001074 dimer interface [polypeptide binding]; other site 150340001075 conserved gate region; other site 150340001076 putative PBP binding loops; other site 150340001077 ABC-ATPase subunit interface; other site 150340001078 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 150340001079 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 150340001080 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 150340001081 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340001082 Walker A/P-loop; other site 150340001083 ATP binding site [chemical binding]; other site 150340001084 Q-loop/lid; other site 150340001085 ABC transporter signature motif; other site 150340001086 Walker B; other site 150340001087 D-loop; other site 150340001088 H-loop/switch region; other site 150340001089 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 150340001090 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340001091 Walker A/P-loop; other site 150340001092 ATP binding site [chemical binding]; other site 150340001093 Q-loop/lid; other site 150340001094 ABC transporter signature motif; other site 150340001095 Walker B; other site 150340001096 D-loop; other site 150340001097 H-loop/switch region; other site 150340001098 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 150340001099 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 150340001100 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 150340001101 motif II; other site 150340001102 Cytochrome c; Region: Cytochrom_C; cl11414 150340001103 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 150340001104 UvrD/REP helicase; Region: UvrD-helicase; cl14126 150340001105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 150340001106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 150340001107 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 150340001108 Outer membrane efflux protein; Region: OEP; pfam02321 150340001109 M28, and M42; Region: Zinc_peptidase_like; cl14876 150340001110 multidrug efflux protein; Reviewed; Region: PRK09579 150340001111 Membrane fusogenic activity; Region: BMFP; cl01115 150340001112 ketol-acid reductoisomerase; Validated; Region: PRK05225 150340001113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340001114 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 150340001115 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 150340001116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340001117 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 150340001118 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 150340001119 putative dimerization interface [polypeptide binding]; other site 150340001120 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 150340001121 Cation transport protein; Region: TrkH; cl10514 150340001122 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 150340001123 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 150340001124 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 150340001125 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 150340001126 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 150340001127 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 150340001128 substrate binding site [chemical binding]; other site 150340001129 oxyanion hole (OAH) forming residues; other site 150340001130 trimer interface [polypeptide binding]; other site 150340001131 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 150340001132 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 150340001133 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 150340001134 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 150340001135 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 150340001136 dimer interface [polypeptide binding]; other site 150340001137 active site 150340001138 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 150340001139 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 150340001140 NADP binding site [chemical binding]; other site 150340001141 dimer interface [polypeptide binding]; other site 150340001142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340001143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340001144 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 150340001145 substrate binding pocket [chemical binding]; other site 150340001146 dimerization interface [polypeptide binding]; other site 150340001147 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 150340001148 CPxP motif; other site 150340001149 Predicted membrane protein [Function unknown]; Region: COG2119 150340001150 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 150340001151 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 150340001152 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 150340001153 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 150340001154 dimer interface [polypeptide binding]; other site 150340001155 motif 1; other site 150340001156 active site 150340001157 motif 2; other site 150340001158 motif 3; other site 150340001159 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 150340001160 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 150340001161 alpha-amylase; Reviewed; Region: malS; PRK09505 150340001162 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 150340001163 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 150340001164 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 150340001165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340001166 homodimer interface [polypeptide binding]; other site 150340001167 catalytic residue [active] 150340001168 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 150340001169 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein...; Region: ACD_IbpA-B_like; cd06470 150340001170 putative dimer interface [polypeptide binding]; other site 150340001171 C-term; Region: GreA_GreB; pfam01272 150340001172 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 150340001173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 150340001174 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 150340001175 anchoring element; other site 150340001176 dimer interface [polypeptide binding]; other site 150340001177 ATP binding site [chemical binding]; other site 150340001178 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 150340001179 active site 150340001180 putative metal-binding site [ion binding]; other site 150340001181 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 150340001182 recombination protein F; Reviewed; Region: recF; PRK00064 150340001183 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340001184 Walker A/P-loop; other site 150340001185 ATP binding site [chemical binding]; other site 150340001186 Q-loop/lid; other site 150340001187 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340001188 ABC transporter signature motif; other site 150340001189 Walker B; other site 150340001190 D-loop; other site 150340001191 H-loop/switch region; other site 150340001192 DNA polymerase III subunit beta; Validated; Region: PRK05643 150340001193 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 150340001194 putative DNA binding surface [nucleotide binding]; other site 150340001195 dimer interface [polypeptide binding]; other site 150340001196 beta-clamp/clamp loader binding surface; other site 150340001197 beta-clamp/translesion DNA polymerase binding surface; other site 150340001198 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 150340001199 hypothetical protein; Validated; Region: PRK06672 150340001200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340001201 Walker A motif; other site 150340001202 ATP binding site [chemical binding]; other site 150340001203 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340001204 Walker B motif; other site 150340001205 arginine finger; other site 150340001206 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 150340001207 DnaA box-binding interface [nucleotide binding]; other site 150340001208 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 150340001209 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 150340001210 substrate binding pocket [chemical binding]; other site 150340001211 membrane-bound complex binding site; other site 150340001212 hinge residues; other site 150340001213 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 150340001214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340001215 dimer interface [polypeptide binding]; other site 150340001216 conserved gate region; other site 150340001217 putative PBP binding loops; other site 150340001218 ABC-ATPase subunit interface; other site 150340001219 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 150340001220 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 150340001221 Walker A/P-loop; other site 150340001222 ATP binding site [chemical binding]; other site 150340001223 Q-loop/lid; other site 150340001224 ABC transporter signature motif; other site 150340001225 Walker B; other site 150340001226 D-loop; other site 150340001227 H-loop/switch region; other site 150340001228 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 150340001229 Ribonuclease P; Region: Ribonuclease_P; cl00457 150340001230 Domain of unknown function DUF37; Region: DUF37; cl00506 150340001231 membrane protein insertase; Provisional; Region: PRK01318 150340001232 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 150340001233 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 150340001234 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 150340001235 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 150340001236 G4 box; other site 150340001237 GTP/Mg2+ binding site [chemical binding]; other site 150340001238 G5 box; other site 150340001239 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 150340001240 G1 box; other site 150340001241 G1 box; other site 150340001242 GTP/Mg2+ binding site [chemical binding]; other site 150340001243 Switch I region; other site 150340001244 Switch I region; other site 150340001245 G2 box; other site 150340001246 G2 box; other site 150340001247 Switch II region; other site 150340001248 G3 box; other site 150340001249 G3 box; other site 150340001250 Switch II region; other site 150340001251 G4 box; other site 150340001252 G5 box; other site 150340001253 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 150340001254 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 150340001255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340001256 glucose-inhibited division protein A; Region: gidA; TIGR00136 150340001257 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 150340001258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340001259 S-adenosylmethionine binding site [chemical binding]; other site 150340001260 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 150340001261 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 150340001262 ParB-like partition proteins; Region: parB_part; TIGR00180 150340001263 ParB-like nuclease domain; Region: ParBc; cl02129 150340001264 ATP synthase I chain; Region: ATP_synt_I; cl09170 150340001265 ATP synthase A chain; Region: ATP-synt_A; cl00413 150340001266 ATP synthase subunit C; Region: ATP-synt_C; cl00466 150340001267 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 150340001268 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 150340001269 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 150340001270 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 150340001271 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 150340001272 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 150340001273 beta subunit interaction interface [polypeptide binding]; other site 150340001274 Walker A motif; other site 150340001275 ATP binding site [chemical binding]; other site 150340001276 Walker B motif; other site 150340001277 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 150340001278 ATP synthase; Region: ATP-synt; cl00365 150340001279 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 150340001280 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 150340001281 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 150340001282 alpha subunit interaction interface [polypeptide binding]; other site 150340001283 Walker A motif; other site 150340001284 ATP binding site [chemical binding]; other site 150340001285 Walker B motif; other site 150340001286 inhibitor binding site; inhibition site 150340001287 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 150340001288 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 150340001289 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 150340001290 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 150340001291 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 150340001292 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 150340001293 Substrate binding site [chemical binding]; other site 150340001294 Mg++ binding site [ion binding]; other site 150340001295 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 150340001296 active site 150340001297 substrate binding site [chemical binding]; other site 150340001298 CoA binding site [chemical binding]; other site 150340001299 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 150340001300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340001301 dimer interface [polypeptide binding]; other site 150340001302 conserved gate region; other site 150340001303 putative PBP binding loops; other site 150340001304 ABC-ATPase subunit interface; other site 150340001305 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 150340001306 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 150340001307 substrate binding pocket [chemical binding]; other site 150340001308 membrane-bound complex binding site; other site 150340001309 hinge residues; other site 150340001310 putative transporter; Provisional; Region: PRK11043 150340001311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340001312 putative substrate translocation pore; other site 150340001313 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 150340001314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340001315 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340001316 dimerization interface [polypeptide binding]; other site 150340001317 threonine dehydratase; Reviewed; Region: PRK09224 150340001318 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 150340001319 tetramer interface [polypeptide binding]; other site 150340001320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340001321 catalytic residue [active] 150340001322 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 150340001323 putative Ile/Val binding site [chemical binding]; other site 150340001324 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 150340001325 putative Ile/Val binding site [chemical binding]; other site 150340001326 Dehydratase family; Region: ILVD_EDD; cl00340 150340001327 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 150340001328 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 150340001329 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 150340001330 homodimer interface [polypeptide binding]; other site 150340001331 substrate-cofactor binding pocket; other site 150340001332 catalytic residue [active] 150340001333 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 150340001334 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 150340001335 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 150340001336 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 150340001337 TPP-binding site [chemical binding]; other site 150340001338 dimer interface [polypeptide binding]; other site 150340001339 Mg chelatase-related protein; Region: TIGR00368 150340001340 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340001341 Protein of unknown function (DUF2860); Region: DUF2860; pfam11059 150340001342 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 150340001343 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 150340001344 putative acyl-acceptor binding pocket; other site 150340001345 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 150340001346 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 150340001347 catalytic residues [active] 150340001348 hinge region; other site 150340001349 alpha helical domain; other site 150340001350 Phosphotransferase enzyme family; Region: APH; pfam01636 150340001351 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 150340001352 active site 150340001353 ATP binding site [chemical binding]; other site 150340001354 substrate binding site [chemical binding]; other site 150340001355 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 150340001356 4Fe-4S binding domain; Region: Fer4_5; pfam12801 150340001357 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 150340001358 Protein of unknown function (DUF1040); Region: DUF1040; cl01176 150340001359 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 150340001360 SpoOM protein; Region: Spo0M; pfam07070 150340001361 Haemolysin-III related; Region: HlyIII; cl03831 150340001362 Protein of unknown function (DUF3157); Region: DUF3157; pfam11355 150340001363 Cation transport protein; Region: TrkH; cl10514 150340001364 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 150340001365 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 150340001366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340001367 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340001368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340001369 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340001370 16S rRNA methyltransferase B; Provisional; Region: PRK10901 150340001371 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 150340001372 putative RNA binding site [nucleotide binding]; other site 150340001373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340001374 S-adenosylmethionine binding site [chemical binding]; other site 150340001375 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 150340001376 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 150340001377 putative active site [active] 150340001378 substrate binding site [chemical binding]; other site 150340001379 putative cosubstrate binding site; other site 150340001380 catalytic site [active] 150340001381 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 150340001382 substrate binding site [chemical binding]; other site 150340001383 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 150340001384 active site 150340001385 catalytic residues [active] 150340001386 metal binding site [ion binding]; metal-binding site 150340001387 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 150340001388 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 150340001389 hypothetical protein; Provisional; Region: PRK10736 150340001390 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 150340001391 Protein of unknown function (DUF494); Region: DUF494; cl01103 150340001392 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 150340001393 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 150340001394 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 150340001395 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 150340001396 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 150340001397 AIR carboxylase; Region: AIRC; cl00310 150340001398 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 150340001399 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 150340001400 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 150340001401 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 150340001402 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 150340001403 shikimate binding site; other site 150340001404 NAD(P) binding site [chemical binding]; other site 150340001405 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 150340001406 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 150340001407 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 150340001408 trimer interface [polypeptide binding]; other site 150340001409 putative metal binding site [ion binding]; other site 150340001410 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 150340001411 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 150340001412 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 150340001413 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 150340001414 CrcB-like protein; Region: CRCB; cl09114 150340001415 ThiC family; Region: ThiC; cl08031 150340001416 thiamine-phosphate pyrophosphorylase; Reviewed; Region: thiE; PRK12290 150340001417 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 150340001418 thiamine phosphate binding site [chemical binding]; other site 150340001419 active site 150340001420 pyrophosphate binding site [ion binding]; other site 150340001421 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 150340001422 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 150340001423 ATP binding site [chemical binding]; other site 150340001424 substrate interface [chemical binding]; other site 150340001425 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 150340001426 thiS-thiF/thiG interaction site; other site 150340001427 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 150340001428 ThiS interaction site; other site 150340001429 putative active site [active] 150340001430 tetramer interface [polypeptide binding]; other site 150340001431 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 150340001432 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 150340001433 FeS/SAM binding site; other site 150340001434 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 150340001435 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 150340001436 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 150340001437 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline...; Region: APP; cd01085 150340001438 active site 150340001439 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 150340001440 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340001441 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 150340001442 substrate binding pocket [chemical binding]; other site 150340001443 dimerization interface [polypeptide binding]; other site 150340001444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340001445 Major Facilitator Superfamily; Region: MFS_1; pfam07690 150340001446 putative substrate translocation pore; other site 150340001447 DoxX; Region: DoxX; cl00976 150340001448 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 150340001449 hypothetical protein; Provisional; Region: PRK05409 150340001450 Protein of unknown function (DUF692); Region: DUF692; cl01263 150340001451 Predicted integral membrane protein (DUF2282); Region: DUF2282; cl02366 150340001452 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 150340001453 UvrD/REP helicase; Region: UvrD-helicase; cl14126 150340001454 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 150340001455 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 150340001456 LysE type translocator; Region: LysE; cl00565 150340001457 Cupin domain; Region: Cupin_2; cl09118 150340001458 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340001459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340001460 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 150340001461 EamA-like transporter family; Region: EamA; cl01037 150340001462 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 150340001463 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 150340001464 ATP binding site [chemical binding]; other site 150340001465 putative Mg++ binding site [ion binding]; other site 150340001466 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340001467 nucleotide binding region [chemical binding]; other site 150340001468 ATP-binding site [chemical binding]; other site 150340001469 RQC domain; Region: RQC; cl09632 150340001470 HRDC domain; Region: HRDC; cl02578 150340001471 Protein of unknown function (DUF3630); Region: DUF3630; pfam12305 150340001472 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 150340001473 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 150340001474 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 150340001475 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 150340001476 ATP binding site [chemical binding]; other site 150340001477 Mg++ binding site [ion binding]; other site 150340001478 motif III; other site 150340001479 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340001480 nucleotide binding region [chemical binding]; other site 150340001481 ATP-binding site [chemical binding]; other site 150340001482 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 150340001483 catalytic residues [active] 150340001484 transcription termination factor Rho; Provisional; Region: rho; PRK09376 150340001485 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 150340001486 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 150340001487 RNA binding site [nucleotide binding]; other site 150340001488 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 150340001489 multimer interface [polypeptide binding]; other site 150340001490 Walker A motif; other site 150340001491 ATP binding site [chemical binding]; other site 150340001492 Walker B motif; other site 150340001493 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 150340001494 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 150340001495 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 150340001496 catalytic loop [active] 150340001497 iron binding site [ion binding]; other site 150340001498 FMN reductase; Validated; Region: fre; PRK08051 150340001499 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD...; Region: flavin_oxioreductase; cd06189 150340001500 FAD binding pocket [chemical binding]; other site 150340001501 FAD binding motif [chemical binding]; other site 150340001502 phosphate binding motif [ion binding]; other site 150340001503 beta-alpha-beta structure motif; other site 150340001504 NAD binding pocket [chemical binding]; other site 150340001505 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 150340001506 HemY protein N-terminus; Region: HemY_N; pfam07219 150340001507 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 150340001508 HemX; Region: HemX; cl14667 150340001509 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 150340001510 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 150340001511 active site 150340001512 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 150340001513 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 150340001514 domain interfaces; other site 150340001515 active site 150340001516 adenylate cyclase; Provisional; Region: cyaA; PRK09450 150340001517 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 150340001518 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 150340001519 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cd00503 150340001520 putative iron binding site [ion binding]; other site 150340001521 diaminopimelate decarboxylase; Region: lysA; TIGR01048 150340001522 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 150340001523 active site 150340001524 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 150340001525 substrate binding site [chemical binding]; other site 150340001526 catalytic residues [active] 150340001527 dimer interface [polypeptide binding]; other site 150340001528 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 150340001529 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 150340001530 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 150340001531 Protein of unknown function, DUF484; Region: DUF484; cl01228 150340001532 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 150340001533 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 150340001534 Int/Topo IB signature motif; other site 150340001535 active site 150340001536 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 150340001537 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 150340001538 motif II; other site 150340001539 Uncharacterized conserved protein [Function unknown]; Region: COG3287 150340001540 FIST N domain; Region: FIST; cl10701 150340001541 FIST C domain; Region: FIST_C; pfam10442 150340001542 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340001543 metal binding site [ion binding]; metal-binding site 150340001544 active site 150340001545 I-site; other site 150340001546 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340001547 DTW domain; Region: DTW; cl01221 150340001548 Predicted membrane protein [Function unknown]; Region: COG3650 150340001549 EVE domain; Region: EVE; cl00728 150340001550 putative hydrolase; Provisional; Region: PRK10976 150340001551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 150340001552 active site 150340001553 motif I; other site 150340001554 motif II; other site 150340001555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 150340001556 lysophospholipase L2; Provisional; Region: PRK10749 150340001557 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 150340001558 LysE type translocator; Region: LysE; cl00565 150340001559 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 150340001560 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340001561 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 150340001562 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 150340001563 dimerization interface [polypeptide binding]; other site 150340001564 putative DNA binding site [nucleotide binding]; other site 150340001565 putative Zn2+ binding site [ion binding]; other site 150340001566 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 150340001567 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 150340001568 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 150340001569 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 150340001570 active site 150340001571 catalytic residues [active] 150340001572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340001573 putative substrate translocation pore; other site 150340001574 Major Facilitator Superfamily; Region: MFS_1; pfam07690 150340001575 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 150340001576 Acyltransferase family; Region: Acyl_transf_3; pfam01757 150340001577 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 150340001578 YhhN-like protein; Region: YhhN; cl01505 150340001579 Protein of unknown function (DUF2492); Region: DUF2492; cl11278 150340001580 MarC family integral membrane protein; Region: MarC; cl00919 150340001581 Protein of unknown function (DUF1145); Region: DUF1145; cl11481 150340001582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340001583 S-adenosylmethionine binding site [chemical binding]; other site 150340001584 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 150340001585 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 150340001586 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 150340001587 P loop; other site 150340001588 GTP binding site [chemical binding]; other site 150340001589 cell division protein FtsE; Provisional; Region: PRK10908 150340001590 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340001591 Walker A/P-loop; other site 150340001592 ATP binding site [chemical binding]; other site 150340001593 Q-loop/lid; other site 150340001594 ABC transporter signature motif; other site 150340001595 Walker B; other site 150340001596 D-loop; other site 150340001597 H-loop/switch region; other site 150340001598 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 150340001599 FtsX-like permease family; Region: FtsX; pfam02687 150340001600 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 150340001601 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 150340001602 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 150340001603 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 150340001604 DNA binding residues [nucleotide binding] 150340001605 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 150340001606 active site residue [active] 150340001607 intramembrane serine protease GlpG; Provisional; Region: PRK10907 150340001608 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 150340001609 Rhomboid family; Region: Rhomboid; cl11446 150340001610 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 150340001611 UTRA domain; Region: UTRA; cl01230 150340001612 UbiA prenyltransferase family; Region: UbiA; cl00337 150340001613 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 150340001614 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 150340001615 putative acyl-acceptor binding pocket; other site 150340001616 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340001617 LexA repressor; Validated; Region: PRK00215 150340001618 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88)...; Region: Peptidase_S24_S26; cl10465 150340001619 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 150340001620 Catalytic site [active] 150340001621 Leucine carboxyl methyltransferase; Region: LCM; cl01306 150340001622 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 150340001623 MatE; Region: MatE; cl10513 150340001624 MatE; Region: MatE; cl10513 150340001625 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 150340001626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340001627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340001628 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 150340001629 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 150340001630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 150340001631 Protein of unknown function (DUF1422); Region: DUF1422; cl11649 150340001632 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 150340001633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340001634 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 150340001635 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 150340001636 N-terminal plug; other site 150340001637 ligand-binding site [chemical binding]; other site 150340001638 MJ0570-related uncharacterized domain; Region: MJ0570_dom; TIGR00290 150340001639 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_IV; cd01994 150340001640 Ligand Binding Site [chemical binding]; other site 150340001641 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 150340001642 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cl02586 150340001643 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 150340001644 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 150340001645 domain interface [polypeptide binding]; other site 150340001646 putative active site [active] 150340001647 catalytic site [active] 150340001648 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 150340001649 domain interface [polypeptide binding]; other site 150340001650 putative active site [active] 150340001651 catalytic site [active] 150340001652 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340001653 FAD binding domain; Region: FAD_binding_4; pfam01565 150340001654 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 150340001655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340001656 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 150340001657 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 150340001658 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 150340001659 pantothenate kinase; Provisional; Region: PRK05439 150340001660 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 150340001661 ATP-binding site [chemical binding]; other site 150340001662 CoA-binding site [chemical binding]; other site 150340001663 Mg2+-binding site [ion binding]; other site 150340001664 elongation factor Tu; Reviewed; Region: PRK00049 150340001665 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 150340001666 G1 box; other site 150340001667 GEF interaction site [polypeptide binding]; other site 150340001668 GTP/Mg2+ binding site [chemical binding]; other site 150340001669 Switch I region; other site 150340001670 G2 box; other site 150340001671 G3 box; other site 150340001672 Switch II region; other site 150340001673 G4 box; other site 150340001674 G5 box; other site 150340001675 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 150340001676 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 150340001677 Antibiotic Binding Site [chemical binding]; other site 150340001678 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 150340001679 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 150340001680 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 150340001681 putative homodimer interface [polypeptide binding]; other site 150340001682 KOW motif; Region: KOW; cl00354 150340001683 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 150340001684 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 150340001685 23S rRNA interface [nucleotide binding]; other site 150340001686 L7/L12 interface [polypeptide binding]; other site 150340001687 putative thiostrepton binding site; other site 150340001688 L25 interface [polypeptide binding]; other site 150340001689 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 150340001690 mRNA/rRNA interface [nucleotide binding]; other site 150340001691 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 150340001692 23S rRNA interface [nucleotide binding]; other site 150340001693 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 150340001694 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 150340001695 core dimer interface [polypeptide binding]; other site 150340001696 peripheral dimer interface [polypeptide binding]; other site 150340001697 L10 interface [polypeptide binding]; other site 150340001698 L11 interface [polypeptide binding]; other site 150340001699 putative EF-Tu interaction site [polypeptide binding]; other site 150340001700 putative EF-G interaction site [polypeptide binding]; other site 150340001701 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 150340001702 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 150340001703 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 150340001704 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 150340001705 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 150340001706 RPB11 interaction site [polypeptide binding]; other site 150340001707 RPB12 interaction site [polypeptide binding]; other site 150340001708 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 150340001709 RPB3 interaction site [polypeptide binding]; other site 150340001710 RPB1 interaction site [polypeptide binding]; other site 150340001711 RPB11 interaction site [polypeptide binding]; other site 150340001712 RPB10 interaction site [polypeptide binding]; other site 150340001713 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 150340001714 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 150340001715 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 150340001716 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 150340001717 DNA-directed RNA polymerase, beta'' subunit; Region: rpoC2_cyan; TIGR02388 150340001718 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 150340001719 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 150340001720 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 150340001721 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 150340001722 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 150340001723 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 150340001724 DNA binding site [nucleotide binding] 150340001725 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 150340001726 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; cl11478 150340001727 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 150340001728 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 150340001729 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 150340001730 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 150340001731 putative NADH binding site [chemical binding]; other site 150340001732 putative active site [active] 150340001733 nudix motif; other site 150340001734 putative metal binding site [ion binding]; other site 150340001735 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 150340001736 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 150340001737 substrate binding site [chemical binding]; other site 150340001738 active site 150340001739 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 150340001740 putative uracil binding site [chemical binding]; other site 150340001741 putative active site [active] 150340001742 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 150340001743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340001744 Protein of unknown function (DUF416); Region: DUF416; cl01166 150340001745 Domain of unknown function DUF21; Region: DUF21; pfam01595 150340001746 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 150340001747 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 150340001748 IHF dimer interface [polypeptide binding]; other site 150340001749 IHF - DNA interface [nucleotide binding]; other site 150340001750 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 150340001751 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 150340001752 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 150340001753 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 150340001754 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 150340001755 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 150340001756 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 150340001757 purine monophosphate binding site [chemical binding]; other site 150340001758 dimer interface [polypeptide binding]; other site 150340001759 putative catalytic residues [active] 150340001760 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 150340001761 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 150340001762 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 150340001763 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 150340001764 DNA binding residues [nucleotide binding] 150340001765 dimer interface [polypeptide binding]; other site 150340001766 metal binding site [ion binding]; metal-binding site 150340001767 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 150340001768 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340001769 DNA binding site [nucleotide binding] 150340001770 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 150340001771 lysine decarboxylase CadA; Provisional; Region: PRK15400 150340001772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 150340001773 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and...; Region: Orn_deC_like; cd00615 150340001774 homodimer interface [polypeptide binding]; other site 150340001775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340001776 catalytic residue [active] 150340001777 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 150340001778 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 150340001779 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340001780 Walker A/P-loop; other site 150340001781 ATP binding site [chemical binding]; other site 150340001782 Q-loop/lid; other site 150340001783 ABC transporter signature motif; other site 150340001784 Walker B; other site 150340001785 D-loop; other site 150340001786 H-loop/switch region; other site 150340001787 ABC transporter; Region: ABC_tran_2; pfam12848 150340001788 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 150340001789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340001790 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 150340001791 putative substrate translocation pore; other site 150340001792 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340001793 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 150340001794 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 150340001795 FMN binding site [chemical binding]; other site 150340001796 active site 150340001797 catalytic residues [active] 150340001798 substrate binding site [chemical binding]; other site 150340001799 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 150340001800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340001801 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 150340001802 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 150340001803 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 150340001804 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 150340001805 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 150340001806 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 150340001807 carboxyltransferase (CT) interaction site; other site 150340001808 biotinylation site [posttranslational modification]; other site 150340001809 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 150340001810 active site 150340001811 trimer interface [polypeptide binding]; other site 150340001812 dimer interface [polypeptide binding]; other site 150340001813 acetyl-CoA synthetase; Provisional; Region: PRK00174 150340001814 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 150340001815 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 150340001816 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 150340001817 active site 150340001818 substrate binding site [chemical binding]; other site 150340001819 catalytic site [active] 150340001820 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 150340001821 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 150340001822 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 150340001823 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 150340001824 metal binding triad; other site 150340001825 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 150340001826 MFS_1 like family; Region: MFS_1_like; pfam12832 150340001827 Sodium:solute symporter family; Region: SSF; cl00456 150340001828 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340001829 PAS fold; Region: PAS_7; pfam12860 150340001830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340001831 dimer interface [polypeptide binding]; other site 150340001832 phosphorylation site [posttranslational modification] 150340001833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340001834 ATP binding site [chemical binding]; other site 150340001835 Mg2+ binding site [ion binding]; other site 150340001836 G-X-G motif; other site 150340001837 Response regulator receiver domain; Region: Response_reg; pfam00072 150340001838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340001839 active site 150340001840 phosphorylation site [posttranslational modification] 150340001841 intermolecular recognition site; other site 150340001842 dimerization interface [polypeptide binding]; other site 150340001843 fumarate hydratase; Reviewed; Region: fumC; PRK00485 150340001844 Class II fumarases; Region: Fumarase_classII; cd01362 150340001845 active site 150340001846 tetramer interface [polypeptide binding]; other site 150340001847 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 150340001848 Sodium:solute symporter family; Region: SSF; cl00456 150340001849 Predicted membrane protein [Function unknown]; Region: COG4327; cl01781 150340001850 potassium/proton antiporter; Reviewed; Region: PRK05326 150340001851 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 150340001852 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340001853 Transporter associated domain; Region: CorC_HlyC; cl08393 150340001854 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 150340001855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340001856 active site 150340001857 phosphorylation site [posttranslational modification] 150340001858 intermolecular recognition site; other site 150340001859 dimerization interface [polypeptide binding]; other site 150340001860 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 150340001861 DNA binding residues [nucleotide binding] 150340001862 dimerization interface [polypeptide binding]; other site 150340001863 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 150340001864 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 150340001865 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 150340001866 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 150340001867 DsbD alpha interface [polypeptide binding]; other site 150340001868 catalytic residues [active] 150340001869 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 150340001870 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 150340001871 Aspartase; Region: Aspartase; cd01357 150340001872 active sites [active] 150340001873 tetramer interface [polypeptide binding]; other site 150340001874 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 150340001875 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 150340001876 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 150340001877 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 150340001878 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 150340001879 two-component sensor protein; Provisional; Region: cpxA; PRK09470 150340001880 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340001881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340001882 dimer interface [polypeptide binding]; other site 150340001883 phosphorylation site [posttranslational modification] 150340001884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340001885 ATP binding site [chemical binding]; other site 150340001886 Mg2+ binding site [ion binding]; other site 150340001887 G-X-G motif; other site 150340001888 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 150340001889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340001890 active site 150340001891 phosphorylation site [posttranslational modification] 150340001892 intermolecular recognition site; other site 150340001893 dimerization interface [polypeptide binding]; other site 150340001894 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340001895 DNA binding site [nucleotide binding] 150340001896 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 150340001897 dimer interface [polypeptide binding]; other site 150340001898 Cation efflux family; Region: Cation_efflux; cl00316 150340001899 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 150340001900 6-phosphofructokinase; Provisional; Region: PRK03202 150340001901 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 150340001902 active site 150340001903 ADP/pyrophosphate binding site [chemical binding]; other site 150340001904 dimerization interface [polypeptide binding]; other site 150340001905 allosteric effector site; other site 150340001906 fructose-1,6-bisphosphate binding site; other site 150340001907 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 150340001908 MatE; Region: MatE; cl10513 150340001909 MatE; Region: MatE; cl10513 150340001910 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 150340001911 oligomerisation interface [polypeptide binding]; other site 150340001912 mobile loop; other site 150340001913 roof hairpin; other site 150340001914 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 150340001915 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 150340001916 ring oligomerisation interface [polypeptide binding]; other site 150340001917 ATP/Mg binding site [chemical binding]; other site 150340001918 stacking interactions; other site 150340001919 hinge regions; other site 150340001920 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 150340001921 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 150340001922 Presynaptic Site I dimer interface [polypeptide binding]; other site 150340001923 catalytic residues [active] 150340001924 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 150340001925 Synaptic Flat tetramer interface [polypeptide binding]; other site 150340001926 Synaptic Site I dimer interface [polypeptide binding]; other site 150340001927 DNA binding site [nucleotide binding] 150340001928 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 150340001929 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 150340001930 Phage integrase family; Region: Phage_integrase; pfam00589 150340001931 DNA binding site [nucleotide binding] 150340001932 Int/Topo IB signature motif; other site 150340001933 active site 150340001934 MgtC family; Region: MgtC; cl12207 150340001935 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 150340001936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 150340001937 FeS/SAM binding site; other site 150340001938 elongation factor P; Validated; Region: PRK00529 150340001939 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 150340001940 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 150340001941 RNA binding site [nucleotide binding]; other site 150340001942 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 150340001943 RNA binding site [nucleotide binding]; other site 150340001944 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 150340001945 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 150340001946 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 150340001947 Iron-sulfur protein interface; other site 150340001948 proximal quinone binding site [chemical binding]; other site 150340001949 C-subunit interface; other site 150340001950 distal quinone binding site; other site 150340001951 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 150340001952 D-subunit interface [polypeptide binding]; other site 150340001953 Iron-sulfur protein interface; other site 150340001954 proximal quinone binding site [chemical binding]; other site 150340001955 distal quinone binding site [chemical binding]; other site 150340001956 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 150340001957 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 150340001958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340001959 domain; Region: Succ_DH_flav_C; pfam02910 150340001960 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 150340001961 poxB regulator PoxA; Provisional; Region: PRK09350 150340001962 motif 1; other site 150340001963 dimer interface [polypeptide binding]; other site 150340001964 active site 150340001965 motif 2; other site 150340001966 motif 3; other site 150340001967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 150340001968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 150340001969 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 150340001970 Peptidase family M23; Region: Peptidase_M23; pfam01551 150340001971 serine acetyltransferase; Provisional; Region: cysE; PRK11132 150340001972 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 150340001973 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 150340001974 trimer interface [polypeptide binding]; other site 150340001975 active site 150340001976 substrate binding site [chemical binding]; other site 150340001977 CoA binding site [chemical binding]; other site 150340001978 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 150340001979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340001980 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 150340001981 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 150340001982 SecA binding site; other site 150340001983 Preprotein binding site; other site 150340001984 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 150340001985 active site residue [active] 150340001986 Sulfatase; Region: Sulfatase; cl10460 150340001987 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 150340001988 EamA-like transporter family; Region: EamA; cl01037 150340001989 EamA-like transporter family; Region: EamA; cl01037 150340001990 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 150340001991 transmembrane helices; other site 150340001992 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 150340001993 GTPase RsgA; Reviewed; Region: PRK12288 150340001994 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 150340001995 GTPase/OB domain interface [polypeptide binding]; other site 150340001996 GTPase/Zn-binding domain interface [polypeptide binding]; other site 150340001997 GTP/Mg2+ binding site [chemical binding]; other site 150340001998 G4 box; other site 150340001999 G5 box; other site 150340002000 G1 box; other site 150340002001 Switch I region; other site 150340002002 G2 box; other site 150340002003 G3 box; other site 150340002004 Switch II region; other site 150340002005 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 150340002006 putative active site [active] 150340002007 putative substrate binding site [chemical binding]; other site 150340002008 catalytic site [active] 150340002009 dimer interface [polypeptide binding]; other site 150340002010 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 150340002011 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 150340002012 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 150340002013 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 150340002014 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 150340002015 active site 150340002016 metal binding site [ion binding]; metal-binding site 150340002017 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 150340002018 putative peptidoglycan binding site; other site 150340002019 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 150340002020 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 150340002021 putative peptidoglycan binding site; other site 150340002022 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 150340002023 putative peptidoglycan binding site; other site 150340002024 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 150340002025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340002026 ATP binding site [chemical binding]; other site 150340002027 Mg2+ binding site [ion binding]; other site 150340002028 G-X-G motif; other site 150340002029 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 150340002030 ATP binding site [chemical binding]; other site 150340002031 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 150340002032 IPP transferase; Region: IPPT; cl00403 150340002033 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 150340002034 Sm1 motif; other site 150340002035 intra - hexamer interaction site; other site 150340002036 inter - hexamer interaction site [polypeptide binding]; other site 150340002037 nucleotide binding pocket [chemical binding]; other site 150340002038 Sm2 motif; other site 150340002039 GTPase HflX; Provisional; Region: PRK11058 150340002040 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 150340002041 G1 box; other site 150340002042 GTP/Mg2+ binding site [chemical binding]; other site 150340002043 Switch I region; other site 150340002044 G2 box; other site 150340002045 G3 box; other site 150340002046 Switch II region; other site 150340002047 G4 box; other site 150340002048 G5 box; other site 150340002049 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 150340002050 HflK protein; Region: hflK; TIGR01933 150340002051 FtsH protease regulator HflC; Provisional; Region: PRK11029 150340002052 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 150340002053 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275 150340002054 adenylosuccinate synthetase; Provisional; Region: PRK01117 150340002055 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 150340002056 GDP-binding site [chemical binding]; other site 150340002057 ACT binding site; other site 150340002058 IMP binding site; other site 150340002059 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 150340002060 Sel1 repeat; Region: Sel1; cl02723 150340002061 Sel1 repeat; Region: Sel1; cl02723 150340002062 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 150340002063 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 150340002064 heme-binding site [chemical binding]; other site 150340002065 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 150340002066 FAD binding pocket [chemical binding]; other site 150340002067 FAD binding motif [chemical binding]; other site 150340002068 phosphate binding motif [ion binding]; other site 150340002069 beta-alpha-beta structure motif; other site 150340002070 NAD binding pocket [chemical binding]; other site 150340002071 Heme binding pocket [chemical binding]; other site 150340002072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340002073 Rrf2 family protein; Region: rrf2_super; TIGR00738 150340002074 ribonuclease R; Region: RNase_R; TIGR02063 150340002075 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 150340002076 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 150340002077 RNB domain; Region: RNB; pfam00773 150340002078 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 150340002079 RNA binding site [nucleotide binding]; other site 150340002080 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 150340002081 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 150340002082 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 150340002083 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 150340002084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 150340002085 motif II; other site 150340002086 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 150340002087 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 150340002088 active site 150340002089 HIGH motif; other site 150340002090 dimer interface [polypeptide binding]; other site 150340002091 KMSKS motif; other site 150340002092 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 150340002093 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 150340002094 generic binding surface I; other site 150340002095 generic binding surface II; other site 150340002096 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 150340002097 putative catalytic site [active] 150340002098 putative metal binding site [ion binding]; other site 150340002099 putative phosphate binding site [ion binding]; other site 150340002100 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 150340002101 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 150340002102 inhibitor-cofactor binding pocket; inhibition site 150340002103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340002104 catalytic residue [active] 150340002105 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 150340002106 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 150340002107 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 150340002108 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 150340002109 NAD(P) binding site [chemical binding]; other site 150340002110 catalytic residues [active] 150340002111 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 150340002112 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 150340002113 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 150340002114 ligand binding site [chemical binding]; other site 150340002115 flexible hinge region; other site 150340002116 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 150340002117 putative switch regulator; other site 150340002118 non-specific DNA interactions [nucleotide binding]; other site 150340002119 DNA binding site [nucleotide binding] 150340002120 sequence specific DNA binding site [nucleotide binding]; other site 150340002121 putative cAMP binding site [chemical binding]; other site 150340002122 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340002123 Active site [active] 150340002124 Uncharacterised protein family (UPF0270); Region: UPF0270; cl01180 150340002125 putative hydrolase; Provisional; Region: PRK10985 150340002126 Protein of unknown function (DUF2390); Region: DUF2390; cl02376 150340002127 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 150340002128 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 150340002129 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 150340002130 ABC transporter; Region: ABC_tran_2; pfam12848 150340002131 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 150340002132 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 150340002133 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 150340002134 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 150340002135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340002136 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 150340002137 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 150340002138 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 150340002139 catalytic nucleophile [active] 150340002140 SlyX; Region: SlyX; cl01090 150340002141 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 150340002142 structural tetrad; other site 150340002143 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 150340002144 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 150340002145 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 150340002146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 150340002147 YheO-like PAS domain; Region: PAS_6; pfam08348 150340002148 DsrE/DsrF-like family; Region: DrsE; cl00672 150340002149 DsrE/DsrF-like family; Region: DrsE; cl00672 150340002150 DsrE/DsrF-like family; Region: DrsE; cl00672 150340002151 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 150340002152 S17 interaction site [polypeptide binding]; other site 150340002153 S8 interaction site; other site 150340002154 16S rRNA interaction site [nucleotide binding]; other site 150340002155 streptomycin interaction site [chemical binding]; other site 150340002156 23S rRNA interaction site [nucleotide binding]; other site 150340002157 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 150340002158 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 150340002159 elongation factor G; Reviewed; Region: PRK00007 150340002160 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 150340002161 G1 box; other site 150340002162 putative GEF interaction site [polypeptide binding]; other site 150340002163 GTP/Mg2+ binding site [chemical binding]; other site 150340002164 Switch I region; other site 150340002165 G2 box; other site 150340002166 G3 box; other site 150340002167 Switch II region; other site 150340002168 G4 box; other site 150340002169 G5 box; other site 150340002170 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 150340002171 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 150340002172 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 150340002173 elongation factor Tu; Reviewed; Region: PRK00049 150340002174 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 150340002175 G1 box; other site 150340002176 GEF interaction site [polypeptide binding]; other site 150340002177 GTP/Mg2+ binding site [chemical binding]; other site 150340002178 Switch I region; other site 150340002179 G2 box; other site 150340002180 G3 box; other site 150340002181 Switch II region; other site 150340002182 G4 box; other site 150340002183 G5 box; other site 150340002184 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 150340002185 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 150340002186 Antibiotic Binding Site [chemical binding]; other site 150340002187 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 150340002188 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 150340002189 Ferritin-like domain; Region: Ferritin; pfam00210 150340002190 heme binding site [chemical binding]; other site 150340002191 ferroxidase pore; other site 150340002192 ferroxidase diiron center [ion binding]; other site 150340002193 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 150340002194 Malic enzyme, N-terminal domain; Region: malic; pfam00390 150340002195 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 150340002196 putative NAD(P) binding site [chemical binding]; other site 150340002197 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox' sequence; Region: Met_repressor_MetJ; cd00490 150340002198 dimerization interface [polypeptide binding]; other site 150340002199 DNA binding site [nucleotide binding] 150340002200 corepressor binding sites; other site 150340002201 cystathionine gamma-synthase; Provisional; Region: PRK08861 150340002202 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 150340002203 homodimer interface [polypeptide binding]; other site 150340002204 substrate-cofactor binding pocket; other site 150340002205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340002206 catalytic residue [active] 150340002207 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 150340002208 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 150340002209 nucleotide binding site [chemical binding]; other site 150340002210 substrate binding site [chemical binding]; other site 150340002211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340002212 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 150340002213 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 150340002214 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 150340002215 FAD binding site [chemical binding]; other site 150340002216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340002217 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 150340002218 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 150340002219 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 150340002220 acetylornithine deacetylase; Provisional; Region: PRK05111 150340002221 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 150340002222 metal binding site [ion binding]; metal-binding site 150340002223 putative dimer interface [polypeptide binding]; other site 150340002224 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 150340002225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340002226 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 150340002227 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 150340002228 nucleotide binding site [chemical binding]; other site 150340002229 substrate binding site [chemical binding]; other site 150340002230 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 150340002231 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 150340002232 ANP binding site [chemical binding]; other site 150340002233 Substrate Binding Site II [chemical binding]; other site 150340002234 Substrate Binding Site I [chemical binding]; other site 150340002235 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 150340002236 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 150340002237 active sites [active] 150340002238 tetramer interface [polypeptide binding]; other site 150340002239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340002240 Coenzyme A binding pocket [chemical binding]; other site 150340002241 Protein of unknown function (DUF3624); Region: DUF3624; pfam12292 150340002242 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 150340002243 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 150340002244 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 150340002245 catalytic triad [active] 150340002246 dimer interface [polypeptide binding]; other site 150340002247 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 150340002248 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 150340002249 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340002250 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 150340002251 dimerization interface [polypeptide binding]; other site 150340002252 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 150340002253 Transglycosylase; Region: Transgly; cl07896 150340002254 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 150340002255 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 150340002256 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 150340002257 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 150340002258 Pilus assembly protein, PilO; Region: PilO; cl01234 150340002259 Pilus assembly protein, PilP; Region: PilP; cl01235 150340002260 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 150340002261 Secretin and TonB N terminus short domain; Region: STN; cl06624 150340002262 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 150340002263 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 150340002264 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 150340002265 magnesium binding site [ion binding]; other site 150340002266 putative shikimate binding site; other site 150340002267 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 150340002268 active site 150340002269 dimer interface [polypeptide binding]; other site 150340002270 metal binding site [ion binding]; metal-binding site 150340002271 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 150340002272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 150340002273 Sporulation related domain; Region: SPOR; cl10051 150340002274 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 150340002275 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 150340002276 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 150340002277 substrate binding site [chemical binding]; other site 150340002278 hexamer interface [polypeptide binding]; other site 150340002279 metal binding site [ion binding]; metal-binding site 150340002280 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 150340002281 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 150340002282 dimer interface [polypeptide binding]; other site 150340002283 ssDNA binding site [nucleotide binding]; other site 150340002284 tetramer (dimer of dimers) interface [polypeptide binding]; other site 150340002285 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 150340002286 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 150340002287 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 150340002288 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 150340002289 Protein of unknown function, DUF481; Region: DUF481; cl01213 150340002290 replicative DNA helicase; Provisional; Region: PRK08840 150340002291 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 150340002292 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 150340002293 Walker A motif; other site 150340002294 ATP binding site [chemical binding]; other site 150340002295 Walker B motif; other site 150340002296 DNA binding loops [nucleotide binding] 150340002297 alanine racemase; Reviewed; Region: alr; PRK00053 150340002298 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 150340002299 active site 150340002300 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 150340002301 substrate binding site [chemical binding]; other site 150340002302 catalytic residues [active] 150340002303 dimer interface [polypeptide binding]; other site 150340002304 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 150340002305 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 150340002306 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 150340002307 active site 150340002308 dimer interface [polypeptide binding]; other site 150340002309 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 150340002310 dimer interface [polypeptide binding]; other site 150340002311 active site 150340002312 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 150340002313 CheC-like family; Region: CheC; pfam04509 150340002314 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 150340002315 metal binding site 2 [ion binding]; metal-binding site 150340002316 putative DNA binding helix; other site 150340002317 metal binding site 1 [ion binding]; metal-binding site 150340002318 dimer interface [polypeptide binding]; other site 150340002319 structural Zn2+ binding site [ion binding]; other site 150340002320 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 150340002321 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 150340002322 FMN binding site [chemical binding]; other site 150340002323 active site 150340002324 catalytic residues [active] 150340002325 substrate binding site [chemical binding]; other site 150340002326 Phage shock protein G (Phageshock_PspG); Region: Phageshock_PspG; cl11511 150340002327 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 150340002328 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 150340002329 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 150340002330 FAD binding pocket [chemical binding]; other site 150340002331 FAD binding motif [chemical binding]; other site 150340002332 catalytic residues [active] 150340002333 NAD binding pocket [chemical binding]; other site 150340002334 phosphate binding motif [ion binding]; other site 150340002335 beta-alpha-beta structure motif; other site 150340002336 sulfite reductase subunit beta; Provisional; Region: PRK13504 150340002337 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 150340002338 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 150340002339 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 150340002340 Active Sites [active] 150340002341 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 150340002342 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 150340002343 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 150340002344 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 150340002345 substrate binding pocket [chemical binding]; other site 150340002346 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 150340002347 B12 binding site [chemical binding]; other site 150340002348 cobalt ligand [ion binding]; other site 150340002349 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 150340002350 aspartate kinase III; Validated; Region: PRK09084 150340002351 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 150340002352 nucleotide binding site [chemical binding]; other site 150340002353 substrate binding site [chemical binding]; other site 150340002354 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 150340002355 dimer interface [polypeptide binding]; other site 150340002356 allosteric regulatory binding pocket; other site 150340002357 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 150340002358 dimer interface [polypeptide binding]; other site 150340002359 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 150340002360 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-...; Region: AGAT_like; cd06451 150340002361 homodimer interface [polypeptide binding]; other site 150340002362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340002363 catalytic residue [active] 150340002364 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 150340002365 O-Antigen ligase; Region: Wzy_C; cl04850 150340002366 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 150340002367 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 150340002368 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 150340002369 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 150340002370 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 150340002371 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 150340002372 active site 150340002373 tetramer interface [polypeptide binding]; other site 150340002374 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 150340002375 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 150340002376 DNA binding residues [nucleotide binding] 150340002377 dimerization interface [polypeptide binding]; other site 150340002378 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 150340002379 dimer interface [polypeptide binding]; other site 150340002380 ssDNA binding site [nucleotide binding]; other site 150340002381 tetramer (dimer of dimers) interface [polypeptide binding]; other site 150340002382 putative single-stranded DNA-binding protein; Region: PHA01740 150340002383 regulatory protein CsrD; Provisional; Region: PRK11059 150340002384 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340002385 metal binding site [ion binding]; metal-binding site 150340002386 active site 150340002387 I-site; other site 150340002388 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340002389 General secretion pathway, M protein; Region: GspM; cl01222 150340002390 Secretin and TonB N terminus short domain; Region: STN; cl06624 150340002391 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 150340002392 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 150340002393 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340002394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340002395 TPR motif; other site 150340002396 binding surface 150340002397 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 150340002398 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 150340002399 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 150340002400 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 150340002401 Walker A motif; other site 150340002402 ATP binding site [chemical binding]; other site 150340002403 Walker B motif; other site 150340002404 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 150340002405 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 150340002406 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 150340002407 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 150340002408 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 150340002409 hypothetical protein; Provisional; Region: PRK10557 150340002410 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 150340002411 legume lectins; Region: lectin_L-type; cl14058 150340002412 homotetramer interaction site [polypeptide binding]; other site 150340002413 carbohydrate binding site [chemical binding]; other site 150340002414 metal binding site [ion binding]; metal-binding site 150340002415 rod shape-determining protein MreB; Provisional; Region: PRK13927 150340002416 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 150340002417 ATP binding site [chemical binding]; other site 150340002418 profilin binding site; other site 150340002419 rod shape-determining protein MreC; Provisional; Region: PRK13922 150340002420 rod shape-determining protein MreC; Region: MreC; pfam04085 150340002421 rod shape-determining protein MreD; Region: MreD; cl01087 150340002422 Maf-like protein; Region: Maf; pfam02545 150340002423 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 150340002424 active site 150340002425 dimer interface [polypeptide binding]; other site 150340002426 ribonuclease G; Provisional; Region: PRK11712 150340002427 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 150340002428 homodimer interface [polypeptide binding]; other site 150340002429 oligonucleotide binding site [chemical binding]; other site 150340002430 TIGR02099 family protein; Region: TIGR02099 150340002431 Predicted amidohydrolase [General function prediction only]; Region: COG0388 150340002432 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 150340002433 putative active site [active] 150340002434 catalytic triad [active] 150340002435 dimer interface [polypeptide binding]; other site 150340002436 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 150340002437 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 150340002438 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 150340002439 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 150340002440 putative active site [active] 150340002441 PhoH-like protein; Region: PhoH; cl12134 150340002442 ATP-dependent helicase HepA; Validated; Region: PRK04914 150340002443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 150340002444 ATP binding site [chemical binding]; other site 150340002445 putative Mg++ binding site [ion binding]; other site 150340002446 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340002447 nucleotide binding region [chemical binding]; other site 150340002448 ATP-binding site [chemical binding]; other site 150340002449 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 150340002450 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 150340002451 active site 150340002452 glycerate dehydrogenase; Provisional; Region: PRK06932 150340002453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340002454 Protein of unknown function (DUF615); Region: DUF615; cl01147 150340002455 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 150340002456 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 150340002457 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 150340002458 MgtE intracellular N domain; Region: MgtE_N; cl15244 150340002459 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 150340002460 Divalent cation transporter; Region: MgtE; cl00786 150340002461 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 150340002462 dimerization domain swap beta strand [polypeptide binding]; other site 150340002463 regulatory protein interface [polypeptide binding]; other site 150340002464 active site 150340002465 regulatory phosphorylation site [posttranslational modification]; other site 150340002466 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340002467 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 150340002468 active site 150340002469 phosphorylation site [posttranslational modification] 150340002470 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 150340002471 30S subunit binding site; other site 150340002472 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 150340002473 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 150340002474 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 150340002475 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 150340002476 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 150340002477 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 150340002478 Walker A/P-loop; other site 150340002479 ATP binding site [chemical binding]; other site 150340002480 Q-loop/lid; other site 150340002481 ABC transporter signature motif; other site 150340002482 Walker B; other site 150340002483 D-loop; other site 150340002484 H-loop/switch region; other site 150340002485 OstA-like protein; Region: OstA; cl00844 150340002486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 150340002487 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 150340002488 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 150340002489 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 150340002490 putative active site [active] 150340002491 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 150340002492 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 150340002493 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 150340002494 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 150340002495 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 150340002496 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 150340002497 Walker A/P-loop; other site 150340002498 ATP binding site [chemical binding]; other site 150340002499 Q-loop/lid; other site 150340002500 ABC transporter signature motif; other site 150340002501 Walker B; other site 150340002502 D-loop; other site 150340002503 H-loop/switch region; other site 150340002504 Domain of unknown function DUF140; Region: DUF140; cl00510 150340002505 mce related protein; Region: MCE; pfam02470 150340002506 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074 150340002507 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 150340002508 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 150340002509 BolA-like protein; Region: BolA; cl00386 150340002510 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 150340002511 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 150340002512 hinge; other site 150340002513 active site 150340002514 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 150340002515 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 150340002516 putative acyl-acceptor binding pocket; other site 150340002517 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 150340002518 homotrimer interaction site [polypeptide binding]; other site 150340002519 putative active site [active] 150340002520 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 150340002521 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 150340002522 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 150340002523 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 150340002524 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 150340002525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340002526 ornithine carbamoyltransferase; Validated; Region: PRK02102 150340002527 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 150340002528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340002529 Amidinotransferase; Region: Amidinotransf; cl12043 150340002530 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 150340002531 Protein of unknown function (DUF1260); Region: DUF1260; cl01170 150340002532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 150340002533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340002534 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 150340002535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340002536 Coenzyme A binding pocket [chemical binding]; other site 150340002537 Predicted membrane protein (DUF2061); Region: DUF2061; cl01257 150340002538 Predicted membrane protein (DUF2061); Region: DUF2061; cl01257 150340002539 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 150340002540 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 150340002541 HIGH motif; other site 150340002542 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 150340002543 active site 150340002544 KMSKS motif; other site 150340002545 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 150340002546 tRNA binding surface [nucleotide binding]; other site 150340002547 anticodon binding site; other site 150340002548 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 150340002549 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 150340002550 multifunctional aminopeptidase A; Provisional; Region: PRK00913 150340002551 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 150340002552 interface (dimer of trimers) [polypeptide binding]; other site 150340002553 Substrate-binding/catalytic site; other site 150340002554 Zn-binding sites [ion binding]; other site 150340002555 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 150340002556 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 150340002557 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 150340002558 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 150340002559 RDD family; Region: RDD; cl00746 150340002560 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 150340002561 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 150340002562 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 150340002563 putative NAD(P) binding site [chemical binding]; other site 150340002564 homotetramer interface [polypeptide binding]; other site 150340002565 active site 150340002566 homodimer interface [polypeptide binding]; other site 150340002567 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 150340002568 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 150340002569 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 150340002570 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 150340002571 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340002572 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 150340002573 active site 150340002574 methionine cluster; other site 150340002575 phosphorylation site [posttranslational modification] 150340002576 metal binding site [ion binding]; metal-binding site 150340002577 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 150340002578 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 150340002579 NAD binding site [chemical binding]; other site 150340002580 sugar binding site [chemical binding]; other site 150340002581 divalent metal binding site [ion binding]; other site 150340002582 tetramer (dimer of dimers) interface [polypeptide binding]; other site 150340002583 dimer interface [polypeptide binding]; other site 150340002584 YdjC-like protein; Region: YdjC; cl01344 150340002585 Transcriptional regulators [Transcription]; Region: PurR; COG1609 150340002586 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 150340002587 DNA binding site [nucleotide binding] 150340002588 domain linker motif; other site 150340002589 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 150340002590 dimerization interface (closed form) [polypeptide binding]; other site 150340002591 ligand binding site [chemical binding]; other site 150340002592 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 150340002593 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 150340002594 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 150340002595 Zn2+ binding site [ion binding]; other site 150340002596 Mg2+ binding site [ion binding]; other site 150340002597 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 150340002598 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 150340002599 tetramerization interface [polypeptide binding]; other site 150340002600 NAD(P) binding site [chemical binding]; other site 150340002601 catalytic residues [active] 150340002602 Cache domain; Region: Cache_2; cl07034 150340002603 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 150340002604 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340002605 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 150340002606 murein transglycosylase C; Provisional; Region: mltC; PRK11671 150340002607 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 150340002608 N-acetyl-D-glucosamine binding site [chemical binding]; other site 150340002609 catalytic residue [active] 150340002610 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 150340002611 adenine DNA glycosylase; Provisional; Region: PRK10880 150340002612 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 150340002613 minor groove reading motif; other site 150340002614 helix-hairpin-helix signature motif; other site 150340002615 substrate binding pocket [chemical binding]; other site 150340002616 active site 150340002617 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 150340002618 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 150340002619 DNA binding and oxoG recognition site [nucleotide binding] 150340002620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340002621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340002622 Glutaminase; Region: Glutaminase; cl00907 150340002623 HemN family oxidoreductase; Provisional; Region: PRK05660 150340002624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 150340002625 FeS/SAM binding site; other site 150340002626 HemN C-terminal region; Region: HemN_C; pfam06969 150340002627 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 150340002628 active site 150340002629 dimerization interface [polypeptide binding]; other site 150340002630 Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811 150340002631 YGGT family; Region: YGGT; cl00508 150340002632 YGGT family; Region: YGGT; cl00508 150340002633 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 150340002634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340002635 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 150340002636 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 150340002637 catalytic residue [active] 150340002638 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 150340002639 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 150340002640 Walker A motif; other site 150340002641 ATP binding site [chemical binding]; other site 150340002642 Walker B motif; other site 150340002643 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 150340002644 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 150340002645 Walker A motif; other site 150340002646 ATP binding site [chemical binding]; other site 150340002647 Walker B motif; other site 150340002648 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 150340002649 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 150340002650 glutathione synthetase; Provisional; Region: PRK05246 150340002651 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 150340002652 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 150340002653 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 150340002654 Endonuclease I; Region: Endonuclease_1; cl01003 150340002655 SprT homologues; Region: SprT; cl01182 150340002656 SprT-like family; Region: SprT-like; pfam10263 150340002657 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 150340002658 S-adenosylmethionine synthetase; Validated; Region: PRK05250 150340002659 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 150340002660 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 150340002661 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 150340002662 transketolase; Reviewed; Region: PRK12753 150340002663 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 150340002664 TPP-binding site [chemical binding]; other site 150340002665 dimer interface [polypeptide binding]; other site 150340002666 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 150340002667 PYR/PP interface [polypeptide binding]; other site 150340002668 dimer interface [polypeptide binding]; other site 150340002669 TPP binding site [chemical binding]; other site 150340002670 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 150340002671 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340002672 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340002673 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340002674 dimerization interface [polypeptide binding]; other site 150340002675 enterobactin receptor protein; Provisional; Region: PRK13483 150340002676 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 150340002677 N-terminal plug; other site 150340002678 ligand-binding site [chemical binding]; other site 150340002679 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 150340002680 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 150340002681 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 150340002682 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 150340002683 substrate binding site [chemical binding]; other site 150340002684 hinge regions; other site 150340002685 ADP binding site [chemical binding]; other site 150340002686 catalytic site [active] 150340002687 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 150340002688 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 150340002689 active site 150340002690 intersubunit interface [polypeptide binding]; other site 150340002691 zinc binding site [ion binding]; other site 150340002692 Na+ binding site [ion binding]; other site 150340002693 mechanosensitive channel MscS; Provisional; Region: PRK10334 150340002694 Conserved TM helix; Region: TM_helix; pfam05552 150340002695 Mechanosensitive ion channel; Region: MS_channel; pfam00924 150340002696 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 150340002697 putative deacylase active site [active] 150340002698 LysE type translocator; Region: LysE; cl00565 150340002699 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 150340002700 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340002701 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 150340002702 putative dimerization interface [polypeptide binding]; other site 150340002703 Protein of unknown function (DUF541); Region: SIMPL; cl01077 150340002704 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 150340002705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340002706 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 150340002707 L-serine binding site [chemical binding]; other site 150340002708 ACT domain interface; other site 150340002709 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 150340002710 tetramer (dimer of dimers) interface [polypeptide binding]; other site 150340002711 active site 150340002712 dimer interface [polypeptide binding]; other site 150340002713 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 150340002714 Cell division protein ZapA; Region: ZapA; cl01146 150340002715 Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173 150340002716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340002717 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 150340002718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340002719 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 150340002720 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 150340002721 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 150340002722 putative deacylase active site [active] 150340002723 putative global regulator; Reviewed; Region: PRK09559 150340002724 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 150340002725 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 150340002726 L-aspartate oxidase; Provisional; Region: PRK09077 150340002727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340002728 domain; Region: Succ_DH_flav_C; pfam02910 150340002729 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 150340002730 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 150340002731 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 150340002732 DNA binding residues [nucleotide binding] 150340002733 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 150340002734 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 150340002735 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 150340002736 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 150340002737 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 150340002738 GTP-binding protein LepA; Provisional; Region: PRK05433 150340002739 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 150340002740 Switch I region; other site 150340002741 G2 box; other site 150340002742 putative GEF interaction site [polypeptide binding]; other site 150340002743 G3 box; other site 150340002744 Switch II region; other site 150340002745 GTP/Mg2+ binding site [chemical binding]; other site 150340002746 G4 box; other site 150340002747 G5 box; other site 150340002748 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 150340002749 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 150340002750 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 150340002751 signal peptidase I; Provisional; Region: PRK10861 150340002752 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 150340002753 Catalytic site [active] 150340002754 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 150340002755 ribonuclease III; Reviewed; Region: rnc; PRK00102 150340002756 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 150340002757 dimerization interface [polypeptide binding]; other site 150340002758 active site 150340002759 metal binding site [ion binding]; metal-binding site 150340002760 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 150340002761 dsRNA binding site [nucleotide binding]; other site 150340002762 GTPase Era; Reviewed; Region: era; PRK00089 150340002763 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 150340002764 G1 box; other site 150340002765 GTP/Mg2+ binding site [chemical binding]; other site 150340002766 Switch I region; other site 150340002767 G2 box; other site 150340002768 Switch II region; other site 150340002769 G3 box; other site 150340002770 G4 box; other site 150340002771 G5 box; other site 150340002772 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 150340002773 Recombination protein O N terminal; Region: RecO_N; pfam11967 150340002774 Recombination protein O C terminal; Region: RecO_C; pfam02565 150340002775 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 150340002776 active site 150340002777 hydrophilic channel; other site 150340002778 dimerization interface [polypeptide binding]; other site 150340002779 catalytic residues [active] 150340002780 active site lid [active] 150340002781 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 150340002782 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 150340002783 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 150340002784 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340002785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340002786 dimer interface [polypeptide binding]; other site 150340002787 phosphorylation site [posttranslational modification] 150340002788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340002789 ATP binding site [chemical binding]; other site 150340002790 Mg2+ binding site [ion binding]; other site 150340002791 G-X-G motif; other site 150340002792 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 150340002793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340002794 active site 150340002795 phosphorylation site [posttranslational modification] 150340002796 intermolecular recognition site; other site 150340002797 dimerization interface [polypeptide binding]; other site 150340002798 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 150340002799 putative binding surface; other site 150340002800 active site 150340002801 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 150340002802 TRAM domain; Region: TRAM; cl01282 150340002803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340002804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340002805 S-adenosylmethionine binding site [chemical binding]; other site 150340002806 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 150340002807 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 150340002808 synthetase active site [active] 150340002809 NTP binding site [chemical binding]; other site 150340002810 metal binding site [ion binding]; metal-binding site 150340002811 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 150340002812 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 150340002813 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 150340002814 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 150340002815 CTP synthetase; Validated; Region: pyrG; PRK05380 150340002816 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 150340002817 Catalytic site [active] 150340002818 Active site [active] 150340002819 UTP binding site [chemical binding]; other site 150340002820 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 150340002821 active site 150340002822 putative oxyanion hole; other site 150340002823 catalytic triad [active] 150340002824 enolase; Provisional; Region: eno; PRK00077 150340002825 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 150340002826 dimer interface [polypeptide binding]; other site 150340002827 metal binding site [ion binding]; metal-binding site 150340002828 substrate binding pocket [chemical binding]; other site 150340002829 Septum formation initiator; Region: DivIC; cl11433 150340002830 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 150340002831 substrate binding site [chemical binding]; other site 150340002832 dimer interface [polypeptide binding]; other site 150340002833 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 150340002834 homotrimer interaction site [polypeptide binding]; other site 150340002835 zinc binding site [ion binding]; other site 150340002836 CDP-binding sites; other site 150340002837 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 150340002838 PseudoU_synth_EcTruD: Pseudouridine synthase, TruD family. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_EcTruD; cd02575 150340002839 Permutation of conserved domain; other site 150340002840 active site 150340002841 Survival protein SurE; Region: SurE; cl00448 150340002842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340002843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340002844 S-adenosylmethionine binding site [chemical binding]; other site 150340002845 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 150340002846 putative peptidoglycan binding site; other site 150340002847 Peptidase family M23; Region: Peptidase_M23; pfam01551 150340002848 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 150340002849 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 150340002850 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 150340002851 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 150340002852 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 150340002853 DNA binding residues [nucleotide binding] 150340002854 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 150340002855 MutS domain I; Region: MutS_I; pfam01624 150340002856 MutS domain II; Region: MutS_II; pfam05188 150340002857 MutS family domain IV; Region: MutS_IV; pfam05190 150340002858 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 150340002859 Walker A/P-loop; other site 150340002860 ATP binding site [chemical binding]; other site 150340002861 Q-loop/lid; other site 150340002862 ABC transporter signature motif; other site 150340002863 Walker B; other site 150340002864 D-loop; other site 150340002865 H-loop/switch region; other site 150340002866 Competence-damaged protein; Region: CinA; cl00666 150340002867 recombinase A; Provisional; Region: recA; PRK09354 150340002868 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 150340002869 hexamer interface [polypeptide binding]; other site 150340002870 Walker A motif; other site 150340002871 ATP binding site [chemical binding]; other site 150340002872 Walker B motif; other site 150340002873 RecX family; Region: RecX; cl00936 150340002874 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 150340002875 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 150340002876 motif 1; other site 150340002877 active site 150340002878 motif 2; other site 150340002879 motif 3; other site 150340002880 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 150340002881 DHHA1 domain; Region: DHHA1; pfam02272 150340002882 aspartate kinase; Validated; Region: PRK08841 150340002883 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 150340002884 putative nucleotide binding site [chemical binding]; other site 150340002885 putative catalytic residues [active] 150340002886 putative Mg ion binding site [ion binding]; other site 150340002887 putative aspartate binding site [chemical binding]; other site 150340002888 Global regulator protein family; Region: CsrA; cl00670 150340002889 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 150340002890 oxaloacetate decarboxylase; Provisional; Region: PRK14040 150340002891 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 150340002892 active site 150340002893 catalytic residues [active] 150340002894 metal binding site [ion binding]; metal-binding site 150340002895 homodimer binding site [polypeptide binding]; other site 150340002896 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 150340002897 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 150340002898 carboxyltransferase (CT) interaction site; other site 150340002899 biotinylation site [posttranslational modification]; other site 150340002900 subunit; Region: OAD_beta; cl00816 150340002901 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 150340002902 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 150340002903 putative NAD(P) binding site [chemical binding]; other site 150340002904 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 150340002905 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 150340002906 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 150340002907 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 150340002908 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 150340002909 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 150340002910 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 150340002911 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099 150340002912 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 150340002913 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 150340002914 Domain of unknown function DUF21; Region: DUF21; pfam01595 150340002915 hypothetical protein; Provisional; Region: PRK11573 150340002916 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 150340002917 Transporter associated domain; Region: CorC_HlyC; cl08393 150340002918 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 150340002919 signal recognition particle protein; Provisional; Region: PRK10867 150340002920 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 150340002921 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 150340002922 P loop; other site 150340002923 GTP binding site [chemical binding]; other site 150340002924 Signal peptide binding domain; Region: SRP_SPB; pfam02978 150340002925 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 150340002926 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 150340002927 RimM N-terminal domain; Region: RimM; pfam01782 150340002928 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 150340002929 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 150340002930 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 150340002931 Domain of unknown function (DUF329); Region: DUF329; cl01144 150340002932 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 150340002933 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 150340002934 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 150340002935 CoA-binding site [chemical binding]; other site 150340002936 ATP-binding [chemical binding]; other site 150340002937 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 150340002938 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 150340002939 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 150340002940 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 150340002941 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 150340002942 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 150340002943 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 150340002944 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 150340002945 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 150340002946 Walker A motif; other site 150340002947 ATP binding site [chemical binding]; other site 150340002948 Walker B motif; other site 150340002949 putative major pilin subunit; Provisional; Region: PRK10574 150340002950 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 150340002951 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 150340002952 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 150340002953 dimerization interface [polypeptide binding]; other site 150340002954 active site 150340002955 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 150340002956 substrate binding site [chemical binding]; other site 150340002957 amidase catalytic site [active] 150340002958 Zn binding residues [ion binding]; other site 150340002959 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 150340002960 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340002961 DNA-binding site [nucleotide binding]; DNA binding site 150340002962 FCD domain; Region: FCD; cl11656 150340002963 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 150340002964 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 150340002965 dimer interface [polypeptide binding]; other site 150340002966 TPP-binding site [chemical binding]; other site 150340002967 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 150340002968 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 150340002969 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 150340002970 E3 interaction surface; other site 150340002971 lipoyl attachment site [posttranslational modification]; other site 150340002972 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 150340002973 E3 interaction surface; other site 150340002974 lipoyl attachment site [posttranslational modification]; other site 150340002975 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 150340002976 E3 interaction surface; other site 150340002977 lipoyl attachment site [posttranslational modification]; other site 150340002978 e3 binding domain; Region: E3_binding; pfam02817 150340002979 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 150340002980 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 150340002981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340002982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340002983 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 150340002984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 150340002985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 150340002986 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 150340002987 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 150340002988 active site clefts [active] 150340002989 zinc binding site [ion binding]; other site 150340002990 dimer interface [polypeptide binding]; other site 150340002991 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 150340002992 Sulfate transporter family; Region: Sulfate_transp; cl00967 150340002993 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 150340002994 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 150340002995 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340002996 Walker A/P-loop; other site 150340002997 ATP binding site [chemical binding]; other site 150340002998 Q-loop/lid; other site 150340002999 ABC transporter signature motif; other site 150340003000 Walker B; other site 150340003001 D-loop; other site 150340003002 H-loop/switch region; other site 150340003003 ABC-2 type transporter; Region: ABC2_membrane; cl11417 150340003004 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 150340003005 putative acyl-acceptor binding pocket; other site 150340003006 pantoate--beta-alanine ligase; Region: panC; TIGR00018 150340003007 Pantoate-beta-alanine ligase; Region: PanC; cd00560 150340003008 active site 150340003009 ATP-binding site [chemical binding]; other site 150340003010 pantoate-binding site; other site 150340003011 HXXH motif; other site 150340003012 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 150340003013 oligomerization interface [polypeptide binding]; other site 150340003014 active site 150340003015 metal binding site [ion binding]; metal-binding site 150340003016 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 150340003017 catalytic center binding site [active] 150340003018 ATP binding site [chemical binding]; other site 150340003019 poly(A) polymerase; Region: pcnB; TIGR01942 150340003020 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 150340003021 active site 150340003022 NTP binding site [chemical binding]; other site 150340003023 metal binding triad [ion binding]; metal-binding site 150340003024 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 150340003025 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 150340003026 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 150340003027 active site 150340003028 nucleotide binding site [chemical binding]; other site 150340003029 HIGH motif; other site 150340003030 KMSKS motif; other site 150340003031 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 150340003032 Sugar fermentation stimulation protein; Region: SfsA; cl00647 150340003033 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 150340003034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 150340003035 ATP binding site [chemical binding]; other site 150340003036 putative Mg++ binding site [ion binding]; other site 150340003037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340003038 nucleotide binding region [chemical binding]; other site 150340003039 ATP-binding site [chemical binding]; other site 150340003040 Helicase associated domain (HA2); Region: HA2; cl04503 150340003041 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 150340003042 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 150340003043 Transglycosylase; Region: Transgly; cl07896 150340003044 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 150340003045 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 150340003046 nucleophile elbow; other site 150340003047 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 150340003048 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 150340003049 Surface antigen; Region: Bac_surface_Ag; cl03097 150340003050 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 150340003051 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change...; Region: AcnB_Swivel; cd01576 150340003052 substrate binding site [chemical binding]; other site 150340003053 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 150340003054 substrate binding site [chemical binding]; other site 150340003055 ligand binding site [chemical binding]; other site 150340003056 Uncharacterised protein family (UPF0231); Region: UPF0231; cl11474 150340003057 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 150340003058 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 150340003059 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340003060 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 150340003061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340003062 dimer interface [polypeptide binding]; other site 150340003063 conserved gate region; other site 150340003064 putative PBP binding loops; other site 150340003065 ABC-ATPase subunit interface; other site 150340003066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 150340003067 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 150340003068 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 150340003069 Walker A/P-loop; other site 150340003070 ATP binding site [chemical binding]; other site 150340003071 Q-loop/lid; other site 150340003072 ABC transporter signature motif; other site 150340003073 Walker B; other site 150340003074 D-loop; other site 150340003075 H-loop/switch region; other site 150340003076 TOBE domain; Region: TOBE_2; cl01440 150340003077 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 150340003078 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a...; Region: PGM_like2; cd05800 150340003079 active site 150340003080 substrate binding site [chemical binding]; other site 150340003081 metal binding site [ion binding]; metal-binding site 150340003082 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 150340003083 Putative carbohydrate binding domain; Region: CBM_X; cl05621 150340003084 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 150340003085 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 150340003086 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 150340003087 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 150340003088 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i); Region: GH20_chitobiase-like; cd06563 150340003089 active site 150340003090 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 150340003091 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 150340003092 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 150340003093 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 150340003094 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 150340003095 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340003096 Walker A/P-loop; other site 150340003097 ATP binding site [chemical binding]; other site 150340003098 Q-loop/lid; other site 150340003099 ABC transporter signature motif; other site 150340003100 Walker B; other site 150340003101 D-loop; other site 150340003102 H-loop/switch region; other site 150340003103 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 150340003104 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 150340003105 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340003106 Walker A/P-loop; other site 150340003107 ATP binding site [chemical binding]; other site 150340003108 Q-loop/lid; other site 150340003109 ABC transporter signature motif; other site 150340003110 Walker B; other site 150340003111 D-loop; other site 150340003112 H-loop/switch region; other site 150340003113 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 150340003114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340003115 dimer interface [polypeptide binding]; other site 150340003116 conserved gate region; other site 150340003117 putative PBP binding loops; other site 150340003118 ABC-ATPase subunit interface; other site 150340003119 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 150340003120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340003121 dimer interface [polypeptide binding]; other site 150340003122 conserved gate region; other site 150340003123 putative PBP binding loops; other site 150340003124 ABC-ATPase subunit interface; other site 150340003125 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 150340003126 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 150340003127 substrate binding site [chemical binding]; other site 150340003128 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 150340003129 dimerization interface [polypeptide binding]; other site 150340003130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340003131 dimer interface [polypeptide binding]; other site 150340003132 phosphorylation site [posttranslational modification] 150340003133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340003134 ATP binding site [chemical binding]; other site 150340003135 Mg2+ binding site [ion binding]; other site 150340003136 G-X-G motif; other site 150340003137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340003138 Response regulator receiver domain; Region: Response_reg; pfam00072 150340003139 active site 150340003140 phosphorylation site [posttranslational modification] 150340003141 intermolecular recognition site; other site 150340003142 dimerization interface [polypeptide binding]; other site 150340003143 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340003144 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 150340003145 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 150340003146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340003147 S-adenosylmethionine binding site [chemical binding]; other site 150340003148 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 150340003149 Domain of unknown function DUF20; Region: UPF0118; cl00465 150340003150 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 150340003151 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 150340003152 inhibitor-cofactor binding pocket; inhibition site 150340003153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340003154 catalytic residue [active] 150340003155 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 150340003156 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 150340003157 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 150340003158 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 150340003159 putative peptidase; Provisional; Region: PRK11649 150340003160 Peptidase family M23; Region: Peptidase_M23; pfam01551 150340003161 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 150340003162 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 150340003163 active site 150340003164 HIGH motif; other site 150340003165 dimer interface [polypeptide binding]; other site 150340003166 KMSKS motif; other site 150340003167 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 150340003168 Divalent cation transporter; Region: MgtE; cl00786 150340003169 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 150340003170 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 150340003171 trimer interface [polypeptide binding]; other site 150340003172 eyelet of channel; other site 150340003173 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 150340003174 domain; Region: GreA_GreB_N; pfam03449 150340003175 C-term; Region: GreA_GreB; pfam01272 150340003176 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 150340003177 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 150340003178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340003179 S-adenosylmethionine binding site [chemical binding]; other site 150340003180 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 150340003181 FtsH Extracellular; Region: FtsH_ext; pfam06480 150340003182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340003183 Walker A motif; other site 150340003184 ATP binding site [chemical binding]; other site 150340003185 Walker B motif; other site 150340003186 arginine finger; other site 150340003187 Peptidase family M41; Region: Peptidase_M41; pfam01434 150340003188 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 150340003189 dihydropteroate synthase; Region: DHPS; TIGR01496 150340003190 substrate binding pocket [chemical binding]; other site 150340003191 dimer interface [polypeptide binding]; other site 150340003192 inhibitor binding site; inhibition site 150340003193 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 150340003194 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 150340003195 active site 150340003196 substrate binding site [chemical binding]; other site 150340003197 metal binding site [ion binding]; metal-binding site 150340003198 Preprotein translocase SecG subunit; Region: SecG; cl09123 150340003199 ribosome maturation protein RimP; Reviewed; Region: PRK00092 150340003200 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 150340003201 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 150340003202 Sm1 motif; other site 150340003203 predicted subunit interaction site [polypeptide binding]; other site 150340003204 RNA binding pocket [nucleotide binding]; other site 150340003205 Sm2 motif; other site 150340003206 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 150340003207 NusA N-terminal domain; Region: NusA_N; pfam08529 150340003208 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 150340003209 RNA binding site [nucleotide binding]; other site 150340003210 homodimer interface [polypeptide binding]; other site 150340003211 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 150340003212 G-X-X-G motif; other site 150340003213 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 150340003214 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 150340003215 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 150340003216 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 150340003217 translation initiation factor IF-2; Region: IF-2; TIGR00487 150340003218 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 150340003219 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 150340003220 G1 box; other site 150340003221 putative GEF interaction site [polypeptide binding]; other site 150340003222 GTP/Mg2+ binding site [chemical binding]; other site 150340003223 Switch I region; other site 150340003224 G2 box; other site 150340003225 G3 box; other site 150340003226 Switch II region; other site 150340003227 G4 box; other site 150340003228 G5 box; other site 150340003229 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 150340003230 Translation-initiation factor 2; Region: IF-2; pfam11987 150340003231 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 150340003232 Ribosome-binding factor A; Region: RBFA; cl00542 150340003233 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 150340003234 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 150340003235 RNA binding site [nucleotide binding]; other site 150340003236 active site 150340003237 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 150340003238 16S/18S rRNA binding site [nucleotide binding]; other site 150340003239 S13e-L30e interaction site [polypeptide binding]; other site 150340003240 25S rRNA binding site [nucleotide binding]; other site 150340003241 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 150340003242 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 150340003243 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 150340003244 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 150340003245 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 150340003246 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 150340003247 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 150340003248 putative nucleic acid binding region [nucleotide binding]; other site 150340003249 G-X-X-G motif; other site 150340003250 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 150340003251 RNA binding site [nucleotide binding]; other site 150340003252 domain interface; other site 150340003253 lipoprotein NlpI; Provisional; Region: PRK11189 150340003254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340003255 binding surface 150340003256 TPR motif; other site 150340003257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340003258 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 150340003259 MatE; Region: MatE; cl10513 150340003260 MatE; Region: MatE; cl10513 150340003261 Peptidase family U32; Region: Peptidase_U32; cl03113 150340003262 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 150340003263 Peptidase family U32; Region: Peptidase_U32; cl03113 150340003264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340003265 PAS domain S-box; Region: sensory_box; TIGR00229 150340003266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340003267 metal binding site [ion binding]; metal-binding site 150340003268 active site 150340003269 I-site; other site 150340003270 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340003271 SCP-2 sterol transfer family; Region: SCP2; cl01225 150340003272 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340003273 Coenzyme A binding pocket [chemical binding]; other site 150340003274 DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436 150340003275 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 150340003276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340003277 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 150340003278 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 150340003279 G1 box; other site 150340003280 putative GEF interaction site [polypeptide binding]; other site 150340003281 GTP/Mg2+ binding site [chemical binding]; other site 150340003282 Switch I region; other site 150340003283 G2 box; other site 150340003284 G3 box; other site 150340003285 Switch II region; other site 150340003286 G4 box; other site 150340003287 G5 box; other site 150340003288 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 150340003289 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 150340003290 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 150340003291 active site 150340003292 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 150340003293 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 150340003294 Nucleoside recognition; Region: Gate; cl00486 150340003295 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 150340003296 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 150340003297 intersubunit interface [polypeptide binding]; other site 150340003298 active site 150340003299 catalytic residue [active] 150340003300 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 150340003301 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 150340003302 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 150340003303 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 150340003304 Sulfatase; Region: Sulfatase; cl10460 150340003305 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 150340003306 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 150340003307 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 150340003308 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 150340003309 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 150340003310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 150340003311 PilZ domain; Region: PilZ; cl01260 150340003312 PilZ domain; Region: PilZ; cl01260 150340003313 DNA repair protein RadA; Provisional; Region: PRK11823 150340003314 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 150340003315 Walker A motif/ATP binding site; other site 150340003316 ATP binding site [chemical binding]; other site 150340003317 Walker B motif; other site 150340003318 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 150340003319 elongation factor G; Reviewed; Region: PRK00007 150340003320 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 150340003321 G1 box; other site 150340003322 putative GEF interaction site [polypeptide binding]; other site 150340003323 GTP/Mg2+ binding site [chemical binding]; other site 150340003324 Switch I region; other site 150340003325 G2 box; other site 150340003326 G3 box; other site 150340003327 Switch II region; other site 150340003328 G4 box; other site 150340003329 G5 box; other site 150340003330 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 150340003331 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 150340003332 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 150340003333 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 150340003334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340003335 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 150340003336 dimerization interface [polypeptide binding]; other site 150340003337 substrate binding pocket [chemical binding]; other site 150340003338 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 150340003339 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 150340003340 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340003341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340003342 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 150340003343 SAF domain; Region: SAF; cl00555 150340003344 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 150340003345 BON domain; Region: BON; cl02771 150340003346 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 150340003347 response regulator PleD; Reviewed; Region: pleD; PRK09581 150340003348 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly...; Region: CpaE_like; cd03111 150340003349 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 150340003350 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly...; Region: CpaE_like; cd03111 150340003351 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 150340003352 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 150340003353 ATP binding site [chemical binding]; other site 150340003354 Walker A motif; other site 150340003355 hexamer interface [polypeptide binding]; other site 150340003356 Walker B motif; other site 150340003357 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 150340003358 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 150340003359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340003360 binding surface 150340003361 TPR motif; other site 150340003362 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340003363 binding surface 150340003364 TPR motif; other site 150340003365 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 150340003366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340003367 binding surface 150340003368 TPR motif; other site 150340003369 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 150340003370 active site 150340003371 Chromate transporter; Region: Chromate_transp; pfam02417 150340003372 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 150340003373 Chromate transporter; Region: Chromate_transp; pfam02417 150340003374 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340003375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340003376 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 150340003377 putative substrate binding pocket [chemical binding]; other site 150340003378 putative dimerization interface [polypeptide binding]; other site 150340003379 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 150340003380 Domain of unknown function (DUF386); Region: DUF386; cl01047 150340003381 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 150340003382 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 150340003383 domain; Region: Glyco_hydro_2; pfam00703 150340003384 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 150340003385 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 150340003386 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 150340003387 DNA binding site [nucleotide binding] 150340003388 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 150340003389 putative dimerization interface [polypeptide binding]; other site 150340003390 putative ligand binding site [chemical binding]; other site 150340003391 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 150340003392 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 150340003393 NAD binding site [chemical binding]; other site 150340003394 homodimer interface [polypeptide binding]; other site 150340003395 active site 150340003396 substrate binding site [chemical binding]; other site 150340003397 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 150340003398 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 150340003399 dimer interface [polypeptide binding]; other site 150340003400 active site 150340003401 galactokinase; Provisional; Region: PRK05101 150340003402 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 150340003403 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 150340003404 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 150340003405 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 150340003406 active site 150340003407 catalytic residues [active] 150340003408 Transcriptional regulators [Transcription]; Region: PurR; COG1609 150340003409 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 150340003410 DNA binding site [nucleotide binding] 150340003411 domain linker motif; other site 150340003412 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 150340003413 putative dimerization interface [polypeptide binding]; other site 150340003414 putative ligand binding site [chemical binding]; other site 150340003415 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 150340003416 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895 150340003417 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 150340003418 putative transporter; Provisional; Region: PRK11462 150340003419 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 150340003420 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 150340003421 DNA binding site [nucleotide binding] 150340003422 domain linker motif; other site 150340003423 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 150340003424 dimerization interface (closed form) [polypeptide binding]; other site 150340003425 ligand binding site [chemical binding]; other site 150340003426 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 150340003427 dimer interface [polypeptide binding]; other site 150340003428 putative tRNA-binding site [nucleotide binding]; other site 150340003429 NnrS protein; Region: NnrS; cl01258 150340003430 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 150340003431 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 150340003432 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 150340003433 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 150340003434 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340003435 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 150340003436 glycerol kinase; Provisional; Region: glpK; PRK00047 150340003437 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 150340003438 N- and C-terminal domain interface [polypeptide binding]; other site 150340003439 active site 150340003440 MgATP binding site [chemical binding]; other site 150340003441 catalytic site [active] 150340003442 metal binding site [ion binding]; metal-binding site 150340003443 glycerol binding site [chemical binding]; other site 150340003444 homotetramer interface [polypeptide binding]; other site 150340003445 homodimer interface [polypeptide binding]; other site 150340003446 FBP binding site [chemical binding]; other site 150340003447 protein IIAGlc interface [polypeptide binding]; other site 150340003448 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 150340003449 amphipathic channel; other site 150340003450 Asn-Pro-Ala signature motifs; other site 150340003451 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 150340003452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340003453 putative substrate translocation pore; other site 150340003454 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 150340003455 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 150340003456 active site 150340003457 catalytic site [active] 150340003458 metal binding site [ion binding]; metal-binding site 150340003459 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 150340003460 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 150340003461 putative trimer interface [polypeptide binding]; other site 150340003462 putative CoA binding site [chemical binding]; other site 150340003463 YebG protein; Region: YebG; cl01217 150340003464 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 150340003465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340003466 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 150340003467 putative dimerization interface [polypeptide binding]; other site 150340003468 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 150340003469 C4-dicarboxylate transporter/malic acid transport protein; Region: C4dic_mal_tran; pfam03595 150340003470 gating phenylalanine in ion channel; other site 150340003471 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 150340003472 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 150340003473 Sulfatase; Region: Sulfatase; cl10460 150340003474 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 150340003475 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 150340003476 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 150340003477 UvrD/REP helicase; Region: UvrD-helicase; cl14126 150340003478 UvrD/REP helicase; Region: UvrD-helicase; cl14126 150340003479 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 150340003480 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 150340003481 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 150340003482 Putative ATPase (DUF699); Region: DUF699; pfam05127 150340003483 N-acetylglutamate synthase; Validated; Region: PRK05279 150340003484 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an N-...; Region: AAK_NAGS-ABP; cd04237 150340003485 putative feedback inhibition sensing region; other site 150340003486 putative nucleotide binding site [chemical binding]; other site 150340003487 putative substrate binding site [chemical binding]; other site 150340003488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340003489 Protein of unknown function (DUF2850); Region: DUF2850; pfam11012 150340003490 murein transglycosylase A; Provisional; Region: mltA; PRK11162 150340003491 MltA specific insert domain; Region: MltA; cl08398 150340003492 3D domain; Region: 3D; cl01439 150340003493 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 150340003494 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755 150340003495 putative ATP binding site [chemical binding]; other site 150340003496 putative substrate interface [chemical binding]; other site 150340003497 Fe-S metabolism associated domain; Region: SufE; cl00951 150340003498 PAS fold; Region: PAS_4; pfam08448 150340003499 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340003500 metal binding site [ion binding]; metal-binding site 150340003501 active site 150340003502 I-site; other site 150340003503 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 150340003504 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 150340003505 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 150340003506 catalytic residue [active] 150340003507 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 150340003508 conserved cys residue [active] 150340003509 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 150340003510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340003511 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 150340003512 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 150340003513 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 150340003514 RNA polymerase sigma factor; Provisional; Region: PRK12531 150340003515 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 150340003516 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 150340003517 DNA binding residues [nucleotide binding] 150340003518 Transcriptional activator [Transcription]; Region: ChrR; COG3806 150340003519 Cupin domain; Region: Cupin_2; cl09118 150340003520 muropeptide transporter; Reviewed; Region: ampG; PRK11902 150340003521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 150340003522 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 150340003523 substrate binding site [chemical binding]; other site 150340003524 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 150340003525 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 150340003526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340003527 S-adenosylmethionine binding site [chemical binding]; other site 150340003528 BolA-like protein; Region: BolA; cl00386 150340003529 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 150340003530 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 150340003531 RnfE family; Region: NQR2_RnfD_RnfE; cl00779 150340003532 FMN-binding domain; Region: FMN_bind; cl01081 150340003533 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 150340003534 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 150340003535 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 150340003536 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 150340003537 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+...; Region: NADH_quinone_reductase; cd06188 150340003538 FAD binding pocket [chemical binding]; other site 150340003539 FAD binding motif [chemical binding]; other site 150340003540 phosphate binding motif [ion binding]; other site 150340003541 beta-alpha-beta structure motif; other site 150340003542 NAD binding pocket [chemical binding]; other site 150340003543 ApbE family; Region: ApbE; cl00643 150340003544 Protein of unknown function (DUF539); Region: DUF539; cl01129 150340003545 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 150340003546 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 150340003547 active site 150340003548 DNA polymerase IV; Validated; Region: PRK02406 150340003549 DNA binding site [nucleotide binding] 150340003550 DEAD-like helicases superfamily; Region: DEXDc; smart00487 150340003551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 150340003552 ATP binding site [chemical binding]; other site 150340003553 putative Mg++ binding site [ion binding]; other site 150340003554 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340003555 nucleotide binding region [chemical binding]; other site 150340003556 ATP-binding site [chemical binding]; other site 150340003557 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 150340003558 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 150340003559 C-term; Region: GreA_GreB; pfam01272 150340003560 Protein of unknown function (DUF2884); Region: DUF2884; cl08135 150340003561 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 150340003562 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 150340003563 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 150340003564 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (...; Region: GH18_chitinase_D-like; cd02871 150340003565 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 150340003566 putative active site [active] 150340003567 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 150340003568 Uncharacterised protein family (UPF0253); Region: UPF0253; cl11640 150340003569 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 150340003570 putative metal binding site [ion binding]; other site 150340003571 prolyl-tRNA synthetase; Provisional; Region: PRK09194 150340003572 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 150340003573 dimer interface [polypeptide binding]; other site 150340003574 motif 1; other site 150340003575 active site 150340003576 motif 2; other site 150340003577 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 150340003578 putative deacylase active site [active] 150340003579 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 150340003580 active site 150340003581 motif 3; other site 150340003582 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 150340003583 anticodon binding site; other site 150340003584 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 150340003585 homodimer interaction site [polypeptide binding]; other site 150340003586 cofactor binding site; other site 150340003587 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 150340003588 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 150340003589 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340003590 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 150340003591 hypothetical protein; Provisional; Region: PRK06849 150340003592 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 150340003593 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 150340003594 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 150340003595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340003596 NAD(P) binding site [chemical binding]; other site 150340003597 active site 150340003598 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 150340003599 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 150340003600 dimer interface [polypeptide binding]; other site 150340003601 active site 150340003602 CoA binding pocket [chemical binding]; other site 150340003603 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 150340003604 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 150340003605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340003606 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 150340003607 Protein of unknown function (DUF3549); Region: DUF3549; pfam12069 150340003608 Domain of unknown function, DUF446; Region: DUF446; cl01187 150340003609 tRNA pseudouridine isomerase C: Pseudouridine synthases catalyze the isomerization of specific uridines in an tRNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. TruC makes psi65 in tRNAs. This psi residue is not...; Region: PseudoU_synth_TruC; cd02563 150340003610 probable active site [active] 150340003611 Protein of unknown function (DUF3461); Region: DUF3461; cl10125 150340003612 PII uridylyl-transferase; Provisional; Region: PRK05007 150340003613 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 150340003614 metal binding triad; other site 150340003615 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 150340003616 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 150340003617 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 150340003618 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 150340003619 methionine aminopeptidase; Reviewed; Region: PRK07281 150340003620 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 150340003621 active site 150340003622 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 150340003623 rRNA interaction site [nucleotide binding]; other site 150340003624 S8 interaction site; other site 150340003625 putative laminin-1 binding site; other site 150340003626 elongation factor Ts; Provisional; Region: tsf; PRK09377 150340003627 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 150340003628 Elongation factor TS; Region: EF_TS; pfam00889 150340003629 Elongation factor TS; Region: EF_TS; pfam00889 150340003630 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 150340003631 putative nucleotide binding site [chemical binding]; other site 150340003632 uridine monophosphate binding site [chemical binding]; other site 150340003633 homohexameric interface [polypeptide binding]; other site 150340003634 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 150340003635 hinge region; other site 150340003636 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 150340003637 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 150340003638 catalytic residue [active] 150340003639 putative FPP diphosphate binding site; other site 150340003640 putative FPP binding hydrophobic cleft; other site 150340003641 dimer interface [polypeptide binding]; other site 150340003642 putative IPP diphosphate binding site; other site 150340003643 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 150340003644 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 150340003645 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 150340003646 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 150340003647 zinc metallopeptidase RseP; Provisional; Region: PRK10779 150340003648 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 150340003649 active site 150340003650 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 150340003651 protein binding site [polypeptide binding]; other site 150340003652 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 150340003653 protein binding site [polypeptide binding]; other site 150340003654 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 150340003655 putative substrate binding region [chemical binding]; other site 150340003656 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 150340003657 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 150340003658 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 150340003659 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 150340003660 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 150340003661 Surface antigen; Region: Bac_surface_Ag; cl03097 150340003662 periplasmic chaperone; Provisional; Region: PRK10780 150340003663 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 150340003664 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 150340003665 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 150340003666 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 150340003667 trimer interface [polypeptide binding]; other site 150340003668 active site 150340003669 UDP-GlcNAc binding site [chemical binding]; other site 150340003670 lipid binding site [chemical binding]; lipid-binding site 150340003671 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 150340003672 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 150340003673 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 150340003674 active site 150340003675 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 150340003676 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 150340003677 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 150340003678 RNA/DNA hybrid binding site [nucleotide binding]; other site 150340003679 active site 150340003680 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 150340003681 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 150340003682 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 150340003683 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 150340003684 generic binding surface II; other site 150340003685 generic binding surface I; other site 150340003686 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 150340003687 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 150340003688 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 150340003689 Ligand Binding Site [chemical binding]; other site 150340003690 TilS substrate binding domain; Region: TilS; pfam09179 150340003691 B3/4 domain; Region: B3_4; cl11458 150340003692 Cytochrome c; Region: Cytochrom_C; cl11414 150340003693 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 150340003694 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 150340003695 Yip1 domain; Region: Yip1; cl12048 150340003696 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 150340003697 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 150340003698 N-acetyl-D-glucosamine binding site [chemical binding]; other site 150340003699 catalytic residue [active] 150340003700 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 150340003701 putative peptidoglycan binding site; other site 150340003702 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 150340003703 putative peptidoglycan binding site; other site 150340003704 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 150340003705 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 150340003706 putative peptidoglycan binding site; other site 150340003707 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 150340003708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340003709 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 150340003710 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 150340003711 RNA/DNA hybrid binding site [nucleotide binding]; other site 150340003712 active site 150340003713 Proteobacterial; Region: dnaQ_proteo; TIGR01406 150340003714 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 150340003715 active site 150340003716 substrate binding site [chemical binding]; other site 150340003717 catalytic site [active] 150340003718 TIGR03503 family protein; Region: TIGR03503 150340003719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340003720 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 150340003721 Sulfate transporter family; Region: Sulfate_transp; cl00967 150340003722 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 150340003723 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 150340003724 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 150340003725 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 150340003726 active site 150340003727 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 150340003728 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 150340003729 dimer interface [polypeptide binding]; other site 150340003730 active site 150340003731 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 150340003732 putative active site [active] 150340003733 putative dimer interface [polypeptide binding]; other site 150340003734 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 150340003735 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 150340003736 active site 150340003737 substrate binding site [chemical binding]; other site 150340003738 cosubstrate binding site; other site 150340003739 catalytic site [active] 150340003740 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 150340003741 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 150340003742 dimerization interface [polypeptide binding]; other site 150340003743 putative ATP binding site [chemical binding]; other site 150340003744 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 150340003745 Permease family; Region: Xan_ur_permease; pfam00860 150340003746 Sulfate transporter family; Region: Sulfate_transp; cl00967 150340003747 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; cl01278 150340003748 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 150340003749 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 150340003750 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 150340003751 catalytic residues [active] 150340003752 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 150340003753 Peptidase family M48; Region: Peptidase_M48; cl12018 150340003754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340003755 binding surface 150340003756 TPR motif; other site 150340003757 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 150340003758 CPxP motif; other site 150340003759 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 150340003760 Domain of unknown function DUF20; Region: UPF0118; cl00465 150340003761 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 150340003762 catalytic triad [active] 150340003763 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 150340003764 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 150340003765 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 150340003766 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 150340003767 dihydrodipicolinate synthase; Region: dapA; TIGR00674 150340003768 dimer interface [polypeptide binding]; other site 150340003769 active site 150340003770 catalytic residue [active] 150340003771 lipoprotein; Provisional; Region: PRK11679 150340003772 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 150340003773 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 150340003774 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 150340003775 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 150340003776 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 150340003777 metal binding site [ion binding]; metal-binding site 150340003778 dimer interface [polypeptide binding]; other site 150340003779 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 150340003780 putative catalytic residues [active] 150340003781 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 150340003782 Protein of unknown function (DUF2956); Region: DUF2956; pfam11169 150340003783 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 150340003784 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 150340003785 flagellin; Reviewed; Region: PRK08869 150340003786 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 150340003787 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 150340003788 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 150340003789 flagellin; Reviewed; Region: PRK08869 150340003790 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 150340003791 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 150340003792 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 150340003793 flagellin; Reviewed; Region: PRK08869 150340003794 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 150340003795 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 150340003796 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 150340003797 FlaG protein; Region: FlaG; cl00591 150340003798 flagellar capping protein; Validated; Region: fliD; PRK08724 150340003799 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 150340003800 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 150340003801 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 150340003802 Flagellar protein FliT; Region: FliT; cl05125 150340003803 Flagellar protein FliS; Region: FliS; cl00654 150340003804 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 150340003805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 150340003806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340003807 Walker A motif; other site 150340003808 ATP binding site [chemical binding]; other site 150340003809 Walker B motif; other site 150340003810 arginine finger; other site 150340003811 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340003812 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 150340003813 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340003814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340003815 dimer interface [polypeptide binding]; other site 150340003816 phosphorylation site [posttranslational modification] 150340003817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340003818 ATP binding site [chemical binding]; other site 150340003819 Mg2+ binding site [ion binding]; other site 150340003820 G-X-G motif; other site 150340003821 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 150340003822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340003823 active site 150340003824 phosphorylation site [posttranslational modification] 150340003825 intermolecular recognition site; other site 150340003826 dimerization interface [polypeptide binding]; other site 150340003827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340003828 Walker A motif; other site 150340003829 ATP binding site [chemical binding]; other site 150340003830 Walker B motif; other site 150340003831 arginine finger; other site 150340003832 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340003833 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 150340003834 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 150340003835 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 150340003836 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 150340003837 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 150340003838 MgtE intracellular N domain; Region: MgtE_N; cl15244 150340003839 FliG C-terminal domain; Region: FliG_C; pfam01706 150340003840 flagellar assembly protein H; Validated; Region: fliH; PRK05687 150340003841 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 150340003842 Flagellar assembly protein FliH; Region: FliH; pfam02108 150340003843 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972 150340003844 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 150340003845 Walker A motif/ATP binding site; other site 150340003846 Walker B motif; other site 150340003847 Flagellar FliJ protein; Region: FliJ; cl09161 150340003848 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 150340003849 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 150340003850 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 150340003851 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 150340003852 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 150340003853 flagellar motor switch protein; Validated; Region: fliN; PRK05698 150340003854 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 150340003855 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 150340003856 FliP family; Region: FliP; cl00593 150340003857 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 150340003858 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 150340003859 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 150340003860 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 150340003861 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 150340003862 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 150340003863 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 150340003864 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 150340003865 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 150340003866 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 150340003867 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 150340003868 P-loop; other site 150340003869 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 150340003870 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 150340003871 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 150340003872 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 150340003873 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 150340003874 DNA binding residues [nucleotide binding] 150340003875 Response regulator receiver domain; Region: Response_reg; pfam00072 150340003876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340003877 active site 150340003878 phosphorylation site [posttranslational modification] 150340003879 intermolecular recognition site; other site 150340003880 dimerization interface [polypeptide binding]; other site 150340003881 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 150340003882 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 150340003883 putative binding surface; other site 150340003884 active site 150340003885 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 150340003886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340003887 ATP binding site [chemical binding]; other site 150340003888 Mg2+ binding site [ion binding]; other site 150340003889 G-X-G motif; other site 150340003890 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 150340003891 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 150340003892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340003893 active site 150340003894 phosphorylation site [posttranslational modification] 150340003895 intermolecular recognition site; other site 150340003896 CheB methylesterase; Region: CheB_methylest; pfam01339 150340003897 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 150340003898 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 150340003899 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 150340003900 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 150340003901 Magnesium ion binding site [ion binding]; other site 150340003902 DNA translocase FtsK; Provisional; Region: PRK10263 150340003903 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 150340003904 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 150340003905 putative CheA interaction surface; other site 150340003906 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 150340003907 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 150340003908 CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH); Region: ABC_CcmA_heme_exporter; cd03231 150340003909 Walker A/P-loop; other site 150340003910 ATP binding site [chemical binding]; other site 150340003911 Q-loop/lid; other site 150340003912 ABC transporter signature motif; other site 150340003913 Walker B; other site 150340003914 D-loop; other site 150340003915 H-loop/switch region; other site 150340003916 CcmB protein; Region: CcmB; cl01016 150340003917 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 150340003918 Heme exporter protein D (CcmD); Region: CcmD; cl11475 150340003919 CcmE; Region: CcmE; cl00994 150340003920 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 150340003921 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 150340003922 catalytic residues [active] 150340003923 central insert; other site 150340003924 Cytochrome C biogenesis protein; Region: CcmH; cl01179 150340003925 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 150340003926 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 150340003927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340003928 binding surface 150340003929 TPR motif; other site 150340003930 VacJ like lipoprotein; Region: VacJ; cl01073 150340003931 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 150340003932 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 150340003933 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 150340003934 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 150340003935 Protein of unknown function (DUF3379); Region: DUF3379; pfam11859 150340003936 RNA polymerase sigma factor; Provisional; Region: PRK11924 150340003937 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 150340003938 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 150340003939 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 150340003940 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 150340003941 dimer interface [polypeptide binding]; other site 150340003942 active site 150340003943 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 150340003944 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 150340003945 substrate binding site [chemical binding]; other site 150340003946 oxyanion hole (OAH) forming residues; other site 150340003947 trimer interface [polypeptide binding]; other site 150340003948 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 150340003949 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 150340003950 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 150340003951 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 150340003952 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 150340003953 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 150340003954 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 150340003955 catalytic core [active] 150340003956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 150340003957 Smr domain; Region: Smr; cl02619 150340003958 HemK family putative methylases; Region: hemK_fam; TIGR00536 150340003959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340003960 S-adenosylmethionine binding site [chemical binding]; other site 150340003961 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 150340003962 Tetramer interface [polypeptide binding]; other site 150340003963 Active site [active] 150340003964 FMN-binding site [chemical binding]; other site 150340003965 Predicted membrane protein [Function unknown]; Region: COG2860 150340003966 UPF0126 domain; Region: UPF0126; pfam03458 150340003967 UPF0126 domain; Region: UPF0126; pfam03458 150340003968 Protein of unknown function, DUF462; Region: DUF462; cl01190 150340003969 YfcL protein; Region: YfcL; pfam08891 150340003970 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 150340003971 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 150340003972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340003973 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 150340003974 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 150340003975 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 150340003976 dimer interface [polypeptide binding]; other site 150340003977 active site 150340003978 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 150340003979 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340003980 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 150340003981 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 150340003982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340003983 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 150340003984 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 150340003985 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 150340003986 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 150340003987 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 150340003988 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 150340003989 dimerization interface 3.5A [polypeptide binding]; other site 150340003990 active site 150340003991 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 150340003992 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 150340003993 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 150340003994 cell division protein DedD; Provisional; Region: PRK11633 150340003995 Sporulation related domain; Region: SPOR; cl10051 150340003996 Colicin V production protein; Region: Colicin_V; cl00567 150340003997 amidophosphoribosyltransferase; Provisional; Region: PRK09246 150340003998 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 150340003999 active site 150340004000 tetramer interface [polypeptide binding]; other site 150340004001 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 150340004002 transcriptional regulator; Provisional; Region: PRK10632 150340004003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340004004 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340004005 putative effector binding pocket; other site 150340004006 dimerization interface [polypeptide binding]; other site 150340004007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340004008 active site 150340004009 response regulator of RpoS; Provisional; Region: PRK10693 150340004010 phosphorylation site [posttranslational modification] 150340004011 intermolecular recognition site; other site 150340004012 dimerization interface [polypeptide binding]; other site 150340004013 Protein of unknown function (DUF454); Region: DUF454; cl01063 150340004014 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 150340004015 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 150340004016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340004017 Walker A motif; other site 150340004018 ATP binding site [chemical binding]; other site 150340004019 Walker B motif; other site 150340004020 arginine finger; other site 150340004021 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 150340004022 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 150340004023 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 150340004024 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 150340004025 RecR protein; Region: RecR; pfam02132 150340004026 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 150340004027 putative active site [active] 150340004028 putative metal-binding site [ion binding]; other site 150340004029 tetramer interface [polypeptide binding]; other site 150340004030 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 150340004031 RHS Repeat; Region: RHS_repeat; cl11982 150340004032 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 150340004033 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 150340004034 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 150340004035 amphipathic channel; other site 150340004036 Asn-Pro-Ala signature motifs; other site 150340004037 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 150340004038 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 150340004039 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 150340004040 homotrimer interaction site [polypeptide binding]; other site 150340004041 putative active site [active] 150340004042 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 150340004043 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 150340004044 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 150340004045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 150340004046 YheO-like PAS domain; Region: PAS_6; pfam08348 150340004047 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 150340004048 Flagellin N-methylase; Region: FliB; cl00497 150340004049 Protein of unknown function (DUF812); Region: DUF812; pfam05667 150340004050 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 150340004051 Mechanosensitive ion channel; Region: MS_channel; pfam00924 150340004052 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 150340004053 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 150340004054 dimer interface [polypeptide binding]; other site 150340004055 active site 150340004056 metal binding site [ion binding]; metal-binding site 150340004057 glutathione binding site [chemical binding]; other site 150340004058 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 150340004059 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cd00016 150340004060 dimer interface [polypeptide binding]; other site 150340004061 active site 150340004062 Protein of unknown function, DUF399; Region: DUF399; cl01139 150340004063 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 150340004064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340004065 S-adenosylmethionine binding site [chemical binding]; other site 150340004066 Cache domain; Region: Cache_1; pfam02743 150340004067 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340004068 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340004069 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 150340004070 active site 150340004071 phosphate binding residues; other site 150340004072 catalytic residues [active] 150340004073 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 150340004074 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 150340004075 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 150340004076 SelR domain; Region: SelR; cl00369 150340004077 Protein of unknown function (DUF2989); Region: DUF2989; pfam11207 150340004078 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 150340004079 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 150340004080 active site/substrate binding site [active] 150340004081 tetramer interface [polypeptide binding]; other site 150340004082 protease 4; Provisional; Region: PRK10949 150340004083 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 150340004084 tandem repeat interface [polypeptide binding]; other site 150340004085 oligomer interface [polypeptide binding]; other site 150340004086 active site residues [active] 150340004087 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 150340004088 tandem repeat interface [polypeptide binding]; other site 150340004089 oligomer interface [polypeptide binding]; other site 150340004090 active site residues [active] 150340004091 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 150340004092 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 150340004093 active site 150340004094 FMN binding site [chemical binding]; other site 150340004095 2,4-decadienoyl-CoA binding site; other site 150340004096 catalytic residue [active] 150340004097 4Fe-4S cluster binding site [ion binding]; other site 150340004098 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 150340004099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340004100 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a beta-...; Region: Arsenite_oxidase; cd02135 150340004101 putative FMN binding site [chemical binding]; other site 150340004102 DNA topoisomerase III; Provisional; Region: PRK07726 150340004103 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362 150340004104 active site 150340004105 putative interdomain interaction site [polypeptide binding]; other site 150340004106 putative metal-binding site [ion binding]; other site 150340004107 putative nucleotide binding site [chemical binding]; other site 150340004108 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 150340004109 domain I; other site 150340004110 DNA binding groove [nucleotide binding] 150340004111 phosphate binding site [ion binding]; other site 150340004112 domain II; other site 150340004113 domain III; other site 150340004114 nucleotide binding site [chemical binding]; other site 150340004115 catalytic site [active] 150340004116 domain IV; other site 150340004117 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 150340004118 NADP binding site [chemical binding]; other site 150340004119 homodimer interface [polypeptide binding]; other site 150340004120 active site 150340004121 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 150340004122 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 150340004123 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 150340004124 Sulfatase; Region: Sulfatase; cl10460 150340004125 Protein of unknown function (DUF1414); Region: DUF1414; cl01175 150340004126 nucleoid-associated protein NdpA; Validated; Region: PRK00378 150340004127 Nucleoid-associated protein [General function prediction only]; Region: COG3081 150340004128 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 150340004129 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 150340004130 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340004131 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 150340004132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340004133 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 150340004134 Ion transport protein; Region: Ion_trans; pfam00520 150340004135 Ion channel; Region: Ion_trans_2; cl11596 150340004136 Double zinc ribbon; Region: DZR; pfam12773 150340004137 MarC family integral membrane protein; Region: MarC; cl00919 150340004138 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 150340004139 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 150340004140 putative catalytic cysteine [active] 150340004141 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 150340004142 putative active site [active] 150340004143 metal binding site [ion binding]; metal-binding site 150340004144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340004145 NAD(P) binding site [chemical binding]; other site 150340004146 active site 150340004147 Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993 150340004148 superoxide dismutase; Provisional; Region: PRK10543 150340004149 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 150340004150 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 150340004151 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 150340004152 putative GSH binding site [chemical binding]; other site 150340004153 catalytic residues [active] 150340004154 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 150340004155 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 150340004156 catalytic residues [active] 150340004157 Predicted permease [General function prediction only]; Region: COG2056 150340004158 GntP family permease; Region: GntP_permease; cl15264 150340004159 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340004160 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 150340004161 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 150340004162 dimer interface [polypeptide binding]; other site 150340004163 putative active site [active] 150340004164 putative substrate binding site [chemical binding]; other site 150340004165 catalytic site [active] 150340004166 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340004167 ligand binding site [chemical binding]; other site 150340004168 Protein of unknown function (DUF2753); Region: DUF2753; pfam10952 150340004169 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 150340004170 dimer interface [polypeptide binding]; other site 150340004171 active site 150340004172 glutathione binding site [chemical binding]; other site 150340004173 metal binding site [ion binding]; metal-binding site 150340004174 endonuclease III; Provisional; Region: PRK10702 150340004175 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 150340004176 minor groove reading motif; other site 150340004177 helix-hairpin-helix signature motif; other site 150340004178 substrate binding pocket [chemical binding]; other site 150340004179 active site 150340004180 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 150340004181 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 150340004182 FMN-binding domain; Region: FMN_bind; cl01081 150340004183 RnfE family; Region: NQR2_RnfD_RnfE; cl00779 150340004184 C subunit; Region: rnfC; TIGR01945 150340004185 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 150340004186 SLBB domain; Region: SLBB; pfam10531 150340004187 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 150340004188 ferredoxin; Provisional; Region: PRK08764 150340004189 Putative Fe-S cluster; Region: FeS; pfam04060 150340004190 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 150340004191 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 150340004192 excinuclease ABC subunit B; Provisional; Region: PRK05298 150340004193 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 150340004194 ATP binding site [chemical binding]; other site 150340004195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340004196 nucleotide binding region [chemical binding]; other site 150340004197 ATP-binding site [chemical binding]; other site 150340004198 Ultra-violet resistance protein B; Region: UvrB; pfam12344 150340004199 UvrB/uvrC motif; Region: UVR; pfam02151 150340004200 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 150340004201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340004202 active site 150340004203 phosphorylation site [posttranslational modification] 150340004204 intermolecular recognition site; other site 150340004205 dimerization interface [polypeptide binding]; other site 150340004206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340004207 Walker A motif; other site 150340004208 ATP binding site [chemical binding]; other site 150340004209 Walker B motif; other site 150340004210 arginine finger; other site 150340004211 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340004212 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 150340004213 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 150340004214 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 150340004215 phosphate binding site [ion binding]; other site 150340004216 putative substrate binding pocket [chemical binding]; other site 150340004217 dimer interface [polypeptide binding]; other site 150340004218 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 150340004219 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 150340004220 FeS/SAM binding site; other site 150340004221 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 150340004222 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 150340004223 MPT binding site; other site 150340004224 trimer interface [polypeptide binding]; other site 150340004225 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 150340004226 trimer interface [polypeptide binding]; other site 150340004227 dimer interface [polypeptide binding]; other site 150340004228 putative active site [active] 150340004229 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 150340004230 MoaE interaction surface [polypeptide binding]; other site 150340004231 MoeB interaction surface [polypeptide binding]; other site 150340004232 thiocarboxylated glycine; other site 150340004233 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 150340004234 MoaE homodimer interface [polypeptide binding]; other site 150340004235 MoaD interaction [polypeptide binding]; other site 150340004236 active site residues [active] 150340004237 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 150340004238 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 150340004239 peptide binding site [polypeptide binding]; other site 150340004240 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 150340004241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340004242 dimer interface [polypeptide binding]; other site 150340004243 conserved gate region; other site 150340004244 putative PBP binding loops; other site 150340004245 ABC-ATPase subunit interface; other site 150340004246 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 150340004247 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 150340004248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340004249 dimer interface [polypeptide binding]; other site 150340004250 conserved gate region; other site 150340004251 putative PBP binding loops; other site 150340004252 ABC-ATPase subunit interface; other site 150340004253 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 150340004254 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340004255 Walker A/P-loop; other site 150340004256 ATP binding site [chemical binding]; other site 150340004257 Q-loop/lid; other site 150340004258 ABC transporter signature motif; other site 150340004259 Walker B; other site 150340004260 D-loop; other site 150340004261 H-loop/switch region; other site 150340004262 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 150340004263 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 150340004264 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340004265 Walker A/P-loop; other site 150340004266 ATP binding site [chemical binding]; other site 150340004267 Q-loop/lid; other site 150340004268 ABC transporter signature motif; other site 150340004269 Walker B; other site 150340004270 D-loop; other site 150340004271 H-loop/switch region; other site 150340004272 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 150340004273 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 150340004274 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 150340004275 putative dimer interface [polypeptide binding]; other site 150340004276 N-terminal domain interface [polypeptide binding]; other site 150340004277 putative substrate binding pocket (H-site) [chemical binding]; other site 150340004278 Predicted membrane protein [Function unknown]; Region: COG3174 150340004279 phosphate acetyltransferase; Reviewed; Region: PRK05632 150340004280 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 150340004281 DRTGG domain; Region: DRTGG; cl12147 150340004282 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 150340004283 Acetokinase family; Region: Acetate_kinase; cl01029 150340004284 Protein of unknown function, DUF412; Region: DUF412; cl01183 150340004285 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984 150340004286 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 150340004287 zinc binding site [ion binding]; other site 150340004288 putative ligand binding site [chemical binding]; other site 150340004289 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 150340004290 TM-ABC transporter signature motif; other site 150340004291 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 150340004292 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340004293 Walker A/P-loop; other site 150340004294 ATP binding site [chemical binding]; other site 150340004295 Q-loop/lid; other site 150340004296 ABC transporter signature motif; other site 150340004297 Walker B; other site 150340004298 D-loop; other site 150340004299 H-loop/switch region; other site 150340004300 maltodextrin glucosidase; Provisional; Region: PRK10785 150340004301 CD and pullulan-degrading enzymes N-terminus domain. Members of this subgroup include: Cyclomaltodextrinase (CDase), maltogenic amylase, and neopullulanase all of which are capable of hydrolyzing all or two of the following three types of substrates:...; Region: CD_pullulan_degrading_enzymes_N_term; cd02857 150340004302 homodimer; other site 150340004303 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 150340004304 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340004305 metal binding site [ion binding]; metal-binding site 150340004306 active site 150340004307 I-site; other site 150340004308 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 150340004309 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 150340004310 FMN binding site [chemical binding]; other site 150340004311 active site 150340004312 catalytic residues [active] 150340004313 substrate binding site [chemical binding]; other site 150340004314 Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173 150340004315 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 150340004316 SEC-C motif; Region: SEC-C; cl12132 150340004317 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 150340004318 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340004319 fatty acid metabolism regulator; Provisional; Region: PRK04984 150340004320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340004321 DNA-binding site [nucleotide binding]; DNA binding site 150340004322 FCD domain; Region: FCD; cl11656 150340004323 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 150340004324 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 150340004325 active site 150340004326 HIGH motif; other site 150340004327 KMSKS motif; other site 150340004328 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 150340004329 tRNA binding surface [nucleotide binding]; other site 150340004330 anticodon binding site; other site 150340004331 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 150340004332 putative tRNA-binding site [nucleotide binding]; other site 150340004333 dimer interface [polypeptide binding]; other site 150340004334 antiporter inner membrane protein; Provisional; Region: PRK11670 150340004335 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 150340004336 Walker A motif; other site 150340004337 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 150340004338 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023 150340004339 ATP-binding site [chemical binding]; other site 150340004340 Sugar specificity; other site 150340004341 Pyrimidine base specificity; other site 150340004342 AsmA family; Region: AsmA; pfam05170 150340004343 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340004344 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 150340004345 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 150340004346 homodimer interface [polypeptide binding]; other site 150340004347 Walker A motif; other site 150340004348 ATP binding site [chemical binding]; other site 150340004349 hydroxycobalamin binding site [chemical binding]; other site 150340004350 Walker B motif; other site 150340004351 Low molecular weight phosphatase family; Region: LMWPc; cd00115 150340004352 Active site [active] 150340004353 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 150340004354 Sulfate transporter family; Region: Sulfate_transp; cl00967 150340004355 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 150340004356 ribonuclease E; Reviewed; Region: rne; PRK10811 150340004357 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 150340004358 homodimer interface [polypeptide binding]; other site 150340004359 oligonucleotide binding site [chemical binding]; other site 150340004360 ribonuclease E; Reviewed; Region: rne; PRK10811 150340004361 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 150340004362 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 150340004363 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 150340004364 active site 150340004365 Maf-like protein; Region: Maf; pfam02545 150340004366 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 150340004367 active site 150340004368 dimer interface [polypeptide binding]; other site 150340004369 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 150340004370 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 150340004371 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 150340004372 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 150340004373 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 150340004374 dimer interface [polypeptide binding]; other site 150340004375 active site 150340004376 CoA binding pocket [chemical binding]; other site 150340004377 Acyl transferase domain; Region: Acyl_transf_1; cl08282 150340004378 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 150340004379 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 150340004380 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 150340004381 NAD(P) binding site [chemical binding]; other site 150340004382 homotetramer interface [polypeptide binding]; other site 150340004383 homodimer interface [polypeptide binding]; other site 150340004384 active site 150340004385 Phosphopantetheine attachment site; Region: PP-binding; cl09936 150340004386 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08722 150340004387 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 150340004388 dimer interface [polypeptide binding]; other site 150340004389 active site 150340004390 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 150340004391 Aminotransferase class IV; Region: Aminotran_4; pfam01063 150340004392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340004393 catalytic residue [active] 150340004394 YceG-like family; Region: YceG; pfam02618 150340004395 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 150340004396 dimerization interface [polypeptide binding]; other site 150340004397 thymidylate kinase; Validated; Region: tmk; PRK00698 150340004398 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 150340004399 TMP-binding site; other site 150340004400 ATP-binding site [chemical binding]; other site 150340004401 DNA polymerase III subunit delta'; Validated; Region: PRK06090 150340004402 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340004403 C terminal; Region: DNApol3-delta_C; pfam09115 150340004404 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 150340004405 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 150340004406 active site 150340004407 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 150340004408 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340004409 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cl00164 150340004410 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 150340004411 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 150340004412 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 150340004413 active site 150340004414 nucleophile elbow; other site 150340004415 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 150340004416 pyruvate kinase; Provisional; Region: PRK05826 150340004417 domain interfaces; other site 150340004418 active site 150340004419 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 150340004420 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 150340004421 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 150340004422 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 150340004423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340004424 active site 150340004425 phosphorylation site [posttranslational modification] 150340004426 intermolecular recognition site; other site 150340004427 dimerization interface [polypeptide binding]; other site 150340004428 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 150340004429 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 150340004430 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 150340004431 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 150340004432 generic binding surface II; other site 150340004433 generic binding surface I; other site 150340004434 DNA Polymerase Y-family; Region: PolY_like; cd03468 150340004435 active site 150340004436 DNA binding site [nucleotide binding] 150340004437 Cell division inhibitor SulA; Region: SulA; cl01880 150340004438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340004439 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 150340004440 NAD(P) binding site [chemical binding]; other site 150340004441 active site 150340004442 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 150340004443 putative inner membrane peptidase; Provisional; Region: PRK11778 150340004444 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 150340004445 tandem repeat interface [polypeptide binding]; other site 150340004446 oligomer interface [polypeptide binding]; other site 150340004447 active site residues [active] 150340004448 cytidylate kinase; Provisional; Region: cmk; PRK00023 150340004449 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 150340004450 CMP-binding site; other site 150340004451 The sites determining sugar specificity; other site 150340004452 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 150340004453 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 150340004454 RNA binding site [nucleotide binding]; other site 150340004455 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 150340004456 RNA binding site [nucleotide binding]; other site 150340004457 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 150340004458 RNA binding site [nucleotide binding]; other site 150340004459 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec4; cd05689 150340004460 RNA binding site [nucleotide binding]; other site 150340004461 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 150340004462 RNA binding site [nucleotide binding]; other site 150340004463 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 150340004464 RNA binding site [nucleotide binding]; other site 150340004465 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 150340004466 IHF dimer interface [polypeptide binding]; other site 150340004467 IHF - DNA interface [nucleotide binding]; other site 150340004468 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 150340004469 tetratricopeptide repeat protein; Provisional; Region: PRK11788 150340004470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340004471 binding surface 150340004472 TPR motif; other site 150340004473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340004474 binding surface 150340004475 TPR motif; other site 150340004476 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 150340004477 active site 150340004478 dimer interface [polypeptide binding]; other site 150340004479 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 150340004480 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 150340004481 Protein of unknown function (DUF330); Region: DUF330; cl01135 150340004482 paraquat-inducible protein B; Provisional; Region: PRK10807 150340004483 mce related protein; Region: MCE; pfam02470 150340004484 mce related protein; Region: MCE; pfam02470 150340004485 mce related protein; Region: MCE; pfam02470 150340004486 Paraquat-inducible protein A; Region: PqiA; pfam04403 150340004487 Paraquat-inducible protein A; Region: PqiA; pfam04403 150340004488 Cytochrome c [Energy production and conversion]; Region: COG3258 150340004489 Cytochrome c; Region: Cytochrom_C; cl11414 150340004490 Cytochrome c; Region: Cytochrom_C; cl11414 150340004491 Cytochrome c; Region: Cytochrom_C; cl11414 150340004492 tetrathionate reductase subunit A; Provisional; Region: PRK14991 150340004493 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 150340004494 putative [Fe4-S4] binding site [ion binding]; other site 150340004495 putative molybdopterin cofactor binding site [chemical binding]; other site 150340004496 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 150340004497 putative molybdopterin cofactor binding site; other site 150340004498 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl01295 150340004499 tetrathionate reductase subunit B; Provisional; Region: PRK14993 150340004500 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 150340004501 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 150340004502 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 150340004503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340004504 dimer interface [polypeptide binding]; other site 150340004505 phosphorylation site [posttranslational modification] 150340004506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340004507 ATP binding site [chemical binding]; other site 150340004508 Mg2+ binding site [ion binding]; other site 150340004509 G-X-G motif; other site 150340004510 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 150340004511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340004512 active site 150340004513 phosphorylation site [posttranslational modification] 150340004514 intermolecular recognition site; other site 150340004515 dimerization interface [polypeptide binding]; other site 150340004516 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 150340004517 DNA binding residues [nucleotide binding] 150340004518 dimerization interface [polypeptide binding]; other site 150340004519 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 150340004520 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 150340004521 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 150340004522 DsbD alpha interface [polypeptide binding]; other site 150340004523 catalytic residues [active] 150340004524 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif...; Region: TlpA_like_ScsD_MtbDsbE; cd03011 150340004525 catalytic residues [active] 150340004526 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 150340004527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340004528 S-adenosylmethionine binding site [chemical binding]; other site 150340004529 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 150340004530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340004531 S-adenosylmethionine binding site [chemical binding]; other site 150340004532 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 150340004533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340004534 Coenzyme A binding pocket [chemical binding]; other site 150340004535 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 150340004536 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 150340004537 Outer membrane efflux protein; Region: OEP; pfam02321 150340004538 Outer membrane efflux protein; Region: OEP; pfam02321 150340004539 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 150340004540 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 150340004541 FtsX-like permease family; Region: FtsX; pfam02687 150340004542 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 150340004543 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 150340004544 FtsX-like permease family; Region: FtsX; pfam02687 150340004545 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 150340004546 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 150340004547 Walker A/P-loop; other site 150340004548 ATP binding site [chemical binding]; other site 150340004549 Q-loop/lid; other site 150340004550 ABC transporter signature motif; other site 150340004551 Walker B; other site 150340004552 D-loop; other site 150340004553 H-loop/switch region; other site 150340004554 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 150340004555 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 150340004556 methionine synthase; Provisional; Region: PRK01207 150340004557 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 150340004558 substrate binding site [chemical binding]; other site 150340004559 THF binding site; other site 150340004560 zinc-binding site [ion binding]; other site 150340004561 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 150340004562 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 150340004563 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340004564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340004565 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340004566 putative effector binding pocket; other site 150340004567 dimerization interface [polypeptide binding]; other site 150340004568 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 150340004569 catalytic triad [active] 150340004570 dimer interface [polypeptide binding]; other site 150340004571 conserved cis-peptide bond; other site 150340004572 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 150340004573 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 150340004574 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs...; Region: LRR_RI; cl15309 150340004575 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 150340004576 Substrate binding site [chemical binding]; other site 150340004577 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 150340004578 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 150340004579 active site 150340004580 ATP binding site [chemical binding]; other site 150340004581 substrate binding site [chemical binding]; other site 150340004582 activation loop (A-loop); other site 150340004583 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 150340004584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340004585 dimer interface [polypeptide binding]; other site 150340004586 phosphorylation site [posttranslational modification] 150340004587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340004588 ATP binding site [chemical binding]; other site 150340004589 Mg2+ binding site [ion binding]; other site 150340004590 G-X-G motif; other site 150340004591 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 150340004592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340004593 active site 150340004594 phosphorylation site [posttranslational modification] 150340004595 intermolecular recognition site; other site 150340004596 dimerization interface [polypeptide binding]; other site 150340004597 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340004598 DNA binding site [nucleotide binding] 150340004599 Cache domain; Region: Cache_1; pfam02743 150340004600 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340004601 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340004602 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340004603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340004604 hypothetical protein; Provisional; Region: PRK01254 150340004605 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 150340004606 PAS fold; Region: PAS; pfam00989 150340004607 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340004608 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340004609 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 150340004610 FOG: CBS domain [General function prediction only]; Region: COG0517 150340004611 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 150340004612 putative dimerization interface [polypeptide binding]; other site 150340004613 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 150340004614 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 150340004615 THF binding site; other site 150340004616 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 150340004617 substrate binding site [chemical binding]; other site 150340004618 THF binding site; other site 150340004619 zinc-binding site [ion binding]; other site 150340004620 YCII-related domain; Region: YCII; cl00999 150340004621 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 150340004622 Intracellular septation protein A; Region: IspA; cl01098 150340004623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 150340004624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340004625 ATP binding site [chemical binding]; other site 150340004626 Mg2+ binding site [ion binding]; other site 150340004627 G-X-G motif; other site 150340004628 Response regulator receiver domain; Region: Response_reg; pfam00072 150340004629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340004630 active site 150340004631 phosphorylation site [posttranslational modification] 150340004632 intermolecular recognition site; other site 150340004633 dimerization interface [polypeptide binding]; other site 150340004634 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 150340004635 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 150340004636 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 150340004637 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 150340004638 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 150340004639 ligand binding site [chemical binding]; other site 150340004640 flexible hinge region; other site 150340004641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340004642 tryptophan synthase; Region: PLN02591 150340004643 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 150340004644 substrate binding site [chemical binding]; other site 150340004645 active site 150340004646 catalytic residues [active] 150340004647 heterodimer interface [polypeptide binding]; other site 150340004648 tryptophan synthase, beta chain; Region: PLN02618 150340004649 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 150340004650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340004651 catalytic residue [active] 150340004652 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 150340004653 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 150340004654 active site 150340004655 ribulose/triose binding site [chemical binding]; other site 150340004656 phosphate binding site [ion binding]; other site 150340004657 substrate (anthranilate) binding pocket [chemical binding]; other site 150340004658 product (indole) binding pocket [chemical binding]; other site 150340004659 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 150340004660 active site 150340004661 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 150340004662 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 150340004663 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 150340004664 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 150340004665 Glutamine amidotransferase class-I; Region: GATase; pfam00117 150340004666 glutamine binding [chemical binding]; other site 150340004667 catalytic triad [active] 150340004668 anthranilate synthase component I; Provisional; Region: PRK13564 150340004669 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 150340004670 chorismate binding enzyme; Region: Chorismate_bind; cl10555 150340004671 Tryptophan operon leader peptide; Region: Trp_leader2; pfam08056 150340004672 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 150340004673 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 150340004674 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 150340004675 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 150340004676 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 150340004677 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 150340004678 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 150340004679 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 150340004680 probable active site [active] 150340004681 Protein of unknown function, DUF440; Region: DUF440; cl11472 150340004682 elongation factor P; Provisional; Region: PRK04542 150340004683 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 150340004684 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 150340004685 RNA binding site [nucleotide binding]; other site 150340004686 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 150340004687 RNA binding site [nucleotide binding]; other site 150340004688 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 150340004689 metal binding triad [ion binding]; metal-binding site 150340004690 DNA polymerase II; Reviewed; Region: PRK05762 150340004691 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 150340004692 active site 150340004693 catalytic site [active] 150340004694 substrate binding site [chemical binding]; other site 150340004695 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 150340004696 active site 150340004697 metal-binding site 150340004698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340004699 active site 150340004700 phosphorylation site [posttranslational modification] 150340004701 intermolecular recognition site; other site 150340004702 dimerization interface [polypeptide binding]; other site 150340004703 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 150340004704 DNA binding residues [nucleotide binding] 150340004705 dimerization interface [polypeptide binding]; other site 150340004706 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 150340004707 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 150340004708 active site 150340004709 catalytic site [active] 150340004710 putative DNA binding site [nucleotide binding]; other site 150340004711 GIY-YIG motif/motif A; other site 150340004712 metal binding site [ion binding]; metal-binding site 150340004713 UvrB/uvrC motif; Region: UVR; pfam02151 150340004714 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 150340004715 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 150340004716 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 150340004717 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 150340004718 inhibitor-cofactor binding pocket; inhibition site 150340004719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340004720 catalytic residue [active] 150340004721 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 150340004722 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 150340004723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340004724 catalytic residue [active] 150340004725 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 150340004726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340004727 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 150340004728 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 150340004729 dimer interface [polypeptide binding]; other site 150340004730 active site 150340004731 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 150340004732 catalytic residues [active] 150340004733 substrate binding site [chemical binding]; other site 150340004734 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 150340004735 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 150340004736 hypothetical protein; Provisional; Region: PRK03673 150340004737 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 150340004738 putative MPT binding site; other site 150340004739 Competence-damaged protein; Region: CinA; cl00666 150340004740 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 150340004741 catalytic loop [active] 150340004742 iron binding site [ion binding]; other site 150340004743 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 150340004744 dimer interface [polypeptide binding]; other site 150340004745 putative radical transfer pathway; other site 150340004746 diiron center [ion binding]; other site 150340004747 tyrosyl radical; other site 150340004748 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 150340004749 ATP cone domain; Region: ATP-cone; pfam03477 150340004750 Class I ribonucleotide reductase; Region: RNR_I; cd01679 150340004751 active site 150340004752 dimer interface [polypeptide binding]; other site 150340004753 catalytic residues [active] 150340004754 effector binding site; other site 150340004755 R2 peptide binding site; other site 150340004756 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 150340004757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340004758 S-adenosylmethionine binding site [chemical binding]; other site 150340004759 DNA gyrase subunit A; Validated; Region: PRK05560 150340004760 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 150340004761 CAP-like domain; other site 150340004762 Active site [active] 150340004763 primary dimer interface [polypeptide binding]; other site 150340004764 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 150340004765 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 150340004766 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 150340004767 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 150340004768 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 150340004769 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 150340004770 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 150340004771 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; cl10556 150340004772 Cytochrome c552; Region: Cytochrom_C552; pfam02335 150340004773 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 150340004774 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 150340004775 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 150340004776 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 150340004777 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl01295 150340004778 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 150340004779 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 150340004780 Cytochrome C biogenesis protein; Region: CcmH; cl01179 150340004781 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 150340004782 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 150340004783 dimerization interface [polypeptide binding]; other site 150340004784 active site 150340004785 Imelysin; Region: Peptidase_M75; cl09159 150340004786 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 150340004787 Imelysin; Region: Peptidase_M75; cl09159 150340004788 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 150340004789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 150340004790 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 150340004791 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 150340004792 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 150340004793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 150340004794 Peptidase M15; Region: Peptidase_M15_3; cl01194 150340004795 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 150340004796 Protein of unknown function (DUF2982); Region: DUF2982; pfam11201 150340004797 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 150340004798 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 150340004799 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340004800 DctM-like transporters; Region: DctM; pfam06808 150340004801 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 150340004802 Cache domain; Region: Cache_2; cl07034 150340004803 Histidine kinase; Region: HisKA_3; pfam07730 150340004804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340004805 ATP binding site [chemical binding]; other site 150340004806 Mg2+ binding site [ion binding]; other site 150340004807 G-X-G motif; other site 150340004808 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 150340004809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340004810 active site 150340004811 phosphorylation site [posttranslational modification] 150340004812 intermolecular recognition site; other site 150340004813 dimerization interface [polypeptide binding]; other site 150340004814 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 150340004815 DNA binding residues [nucleotide binding] 150340004816 dimerization interface [polypeptide binding]; other site 150340004817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340004818 BCCT family transporter; Region: BCCT; cl00569 150340004819 Cache domain; Region: Cache_1; pfam02743 150340004820 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340004821 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340004822 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 150340004823 active site 150340004824 substrate binding site [chemical binding]; other site 150340004825 catalytic site [active] 150340004826 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 150340004827 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 150340004828 ligand binding site [chemical binding]; other site 150340004829 flexible hinge region; other site 150340004830 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain...; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 150340004831 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 150340004832 metal binding triad; other site 150340004833 Surface antigen; Region: Surface_Ag_2; cl01155 150340004834 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 150340004835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340004836 homodimer interface [polypeptide binding]; other site 150340004837 catalytic residue [active] 150340004838 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 150340004839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340004840 DNA-binding site [nucleotide binding]; DNA binding site 150340004841 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 150340004842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340004843 homodimer interface [polypeptide binding]; other site 150340004844 catalytic residue [active] 150340004845 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 150340004846 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318 150340004847 putative dimer interface [polypeptide binding]; other site 150340004848 putative anticodon binding site; other site 150340004849 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 150340004850 homodimer interface [polypeptide binding]; other site 150340004851 motif 1; other site 150340004852 motif 2; other site 150340004853 active site 150340004854 motif 3; other site 150340004855 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 150340004856 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340004857 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340004858 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340004859 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 150340004860 active site 150340004861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340004862 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 150340004863 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340004864 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 150340004865 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 150340004866 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 150340004867 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 150340004868 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 150340004869 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 150340004870 putative active site [active] 150340004871 putative CoA binding site [chemical binding]; other site 150340004872 nudix motif; other site 150340004873 metal binding site [ion binding]; metal-binding site 150340004874 Heme NO binding; Region: HNOB; cl15268 150340004875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 150340004876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340004877 dimer interface [polypeptide binding]; other site 150340004878 phosphorylation site [posttranslational modification] 150340004879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340004880 ATP binding site [chemical binding]; other site 150340004881 Mg2+ binding site [ion binding]; other site 150340004882 G-X-G motif; other site 150340004883 Response regulator receiver domain; Region: Response_reg; pfam00072 150340004884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340004885 active site 150340004886 phosphorylation site [posttranslational modification] 150340004887 intermolecular recognition site; other site 150340004888 dimerization interface [polypeptide binding]; other site 150340004889 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 150340004890 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 150340004891 chorismate binding enzyme; Region: Chorismate_bind; cl10555 150340004892 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 150340004893 Fumarase C-terminus; Region: Fumerase_C; cl00795 150340004894 YcjX-like family, DUF463; Region: DUF463; cl01193 150340004895 hypothetical protein; Provisional; Region: PRK05415 150340004896 Domain of unknown function (DUF697); Region: DUF697; cl12064 150340004897 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 150340004898 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 150340004899 putative aromatic amino acid binding site; other site 150340004900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340004901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340004902 Walker A motif; other site 150340004903 ATP binding site [chemical binding]; other site 150340004904 Walker B motif; other site 150340004905 arginine finger; other site 150340004906 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 150340004907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340004908 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 150340004909 Protein of unknown function (DUF2947); Region: DUF2947; pfam11163 150340004910 integron integrase; Region: integrase_gron; TIGR02249 150340004911 DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and a secondary target called the attC (or 59-base element)...; Region: INT_IntI; cd01193 150340004912 Int/Topo IB signature motif; other site 150340004913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340004914 sugar efflux transporter B; Provisional; Region: PRK15011 150340004915 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 150340004916 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 150340004917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340004918 Coenzyme A binding pocket [chemical binding]; other site 150340004919 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 150340004920 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 150340004921 nudix motif; other site 150340004922 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 150340004923 putative active site [active] 150340004924 Protein of unknown function (DUF3265); Region: DUF3265; pfam11665 150340004925 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 150340004926 active site 150340004927 metal binding site [ion binding]; metal-binding site 150340004928 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 150340004929 Protein of unknown function (DUF3265); Region: DUF3265; pfam11665 150340004930 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 150340004931 active site 150340004932 metal binding site [ion binding]; metal-binding site 150340004933 Protein of unknown function (DUF3265); Region: DUF3265; pfam11665 150340004934 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 150340004935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340004936 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 150340004937 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 150340004938 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 150340004939 active site 150340004940 metal binding site [ion binding]; metal-binding site 150340004941 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 150340004942 GIY-YIG motif/motif A; other site 150340004943 active site 150340004944 catalytic site [active] 150340004945 metal binding site [ion binding]; metal-binding site 150340004946 Protein of unknown function (DUF3265); Region: DUF3265; pfam11665 150340004947 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 150340004948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340004949 Coenzyme A binding pocket [chemical binding]; other site 150340004950 Protein of unknown function (DUF3265); Region: DUF3265; pfam11665 150340004951 Protein of unknown function (DUF2007); Region: DUF2007; pfam09413 150340004952 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 150340004953 Protein of unknown function (DUF3265); Region: DUF3265; pfam11665 150340004954 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 150340004955 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340004956 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340004957 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 150340004958 putative active site [active] 150340004959 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 150340004960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340004961 Cupin domain; Region: Cupin_2; cl09118 150340004962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340004963 Protein of unknown function (DUF3265); Region: DUF3265; pfam11665 150340004964 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 150340004965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340004966 Predicted transcriptional regulator [Transcription]; Region: COG2378 150340004967 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 150340004968 HsdM N-terminal domain; Region: HsdM_N; pfam12161 150340004969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340004970 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 150340004971 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 150340004972 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 150340004973 Protein of unknown function DUF262; Region: DUF262; cl14890 150340004974 Protein of unknown function DUF262; Region: DUF262; cl14890 150340004975 Protein of unknown function DUF262; Region: DUF262; cl14890 150340004976 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 150340004977 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 150340004978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 150340004979 ATP binding site [chemical binding]; other site 150340004980 putative Mg++ binding site [ion binding]; other site 150340004981 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 150340004982 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 150340004983 ligand binding site [chemical binding]; other site 150340004984 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 150340004985 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 150340004986 ATP binding site [chemical binding]; other site 150340004987 putative Mg++ binding site [ion binding]; other site 150340004988 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340004989 Restriction endonuclease; Region: Mrr_cat; cl00747 150340004990 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 150340004991 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 150340004992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 150340004993 integrase; Provisional; Region: PRK09692 150340004994 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 150340004995 active site 150340004996 Int/Topo IB signature motif; other site 150340004997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340004998 Protein of unknown function (DUF3265); Region: DUF3265; pfam11665 150340004999 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 150340005000 nucleotide binding site/active site [active] 150340005001 HIT family signature motif; other site 150340005002 catalytic residue [active] 150340005003 LysE type translocator; Region: LysE; cl00565 150340005004 preprotein translocase subunit SecA; Reviewed; Region: PRK13107 150340005005 SEC-C motif; Region: SEC-C; cl12132 150340005006 Phd_YefM; Region: PhdYeFM; cl09153 150340005007 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 150340005008 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 150340005009 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340005010 Coenzyme A binding pocket [chemical binding]; other site 150340005011 Protein of unknown function (DUF3265); Region: DUF3265; pfam11665 150340005012 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 150340005013 Protein of unknown function (DUF3265); Region: DUF3265; pfam11665 150340005014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340005015 S-adenosylmethionine binding site [chemical binding]; other site 150340005016 Protein of unknown function (DUF3265); Region: DUF3265; pfam11665 150340005017 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 150340005018 ligand binding site [chemical binding]; other site 150340005019 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 150340005020 Protein of unknown function (DUF3265); Region: DUF3265; pfam11665 150340005021 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 150340005022 Protein of unknown function (DUF3265); Region: DUF3265; pfam11665 150340005023 integrase; Provisional; Region: PRK09692 150340005024 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 150340005025 Phage integrase family; Region: Phage_integrase; pfam00589 150340005026 DNA binding site [nucleotide binding] 150340005027 Int/Topo IB signature motif; other site 150340005028 active site 150340005029 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 150340005030 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; cl15276 150340005031 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 150340005032 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340005033 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 150340005034 putative active site [active] 150340005035 putative metal-binding site [ion binding]; other site 150340005036 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 150340005037 UvrD/REP helicase; Region: UvrD-helicase; cl14126 150340005038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340005039 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 150340005040 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 150340005041 putative C-terminal domain interface [polypeptide binding]; other site 150340005042 putative GSH binding site (G-site) [chemical binding]; other site 150340005043 putative dimer interface [polypeptide binding]; other site 150340005044 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 150340005045 dimer interface [polypeptide binding]; other site 150340005046 substrate binding pocket (H-site) [chemical binding]; other site 150340005047 N-terminal domain interface [polypeptide binding]; other site 150340005048 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340005049 Protein of unknown function (DUF2007); Region: DUF2007; pfam09413 150340005050 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 150340005051 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 150340005052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340005053 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 150340005054 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 150340005055 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 150340005056 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 150340005057 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 150340005058 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 150340005059 LysE type translocator; Region: LysE; cl00565 150340005060 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 150340005061 Predicted membrane protein [Function unknown]; Region: COG1289 150340005062 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 150340005063 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 150340005064 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 150340005065 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340005066 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 150340005067 dimerization interface [polypeptide binding]; other site 150340005068 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 150340005069 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 150340005070 ABC-2 type transporter; Region: ABC2_membrane; cl11417 150340005071 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 150340005072 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 150340005073 ABC-2 type transporter; Region: ABC2_membrane; cl11417 150340005074 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 150340005075 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 150340005076 Outer membrane efflux protein; Region: OEP; pfam02321 150340005077 Outer membrane efflux protein; Region: OEP; pfam02321 150340005078 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 150340005079 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340005080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340005081 ATP binding site [chemical binding]; other site 150340005082 Mg2+ binding site [ion binding]; other site 150340005083 G-X-G motif; other site 150340005084 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 150340005085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340005086 active site 150340005087 phosphorylation site [posttranslational modification] 150340005088 intermolecular recognition site; other site 150340005089 dimerization interface [polypeptide binding]; other site 150340005090 Transcriptional regulator; Region: CitT; pfam12431 150340005091 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 150340005092 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 150340005093 N-terminal plug; other site 150340005094 ligand-binding site [chemical binding]; other site 150340005095 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340005096 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340005097 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 150340005098 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 150340005099 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 150340005100 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 150340005101 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 150340005102 putative active site [active] 150340005103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340005104 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 150340005105 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 150340005106 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 150340005107 GAF domain; Region: GAF; cl00853 150340005108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340005109 Walker A motif; other site 150340005110 ATP binding site [chemical binding]; other site 150340005111 Walker B motif; other site 150340005112 arginine finger; other site 150340005113 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340005114 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 150340005115 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 150340005116 NAD(P) binding site [chemical binding]; other site 150340005117 catalytic residues [active] 150340005118 Tir chaperone protein (CesT); Region: CesT; cl08444 150340005119 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl09836 150340005120 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340005121 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340005122 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340005123 Tir chaperone protein (CesT); Region: CesT; cl08444 150340005124 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 150340005125 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 150340005126 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 150340005127 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 150340005128 Protein of unknown function (DUF1895); Region: DUF1895; cl07553 150340005129 Type III secretion needle MxiH like; Region: MxiH; cl09641 150340005130 Bacterial type II secretion system chaperone protein (type_III_yscG); Region: Type_III_YscG; cl09712 150340005131 YopR Core; Region: YopR_core; cl07585 150340005132 Type III secretion needle MxiH like; Region: MxiH; cl09641 150340005133 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 150340005134 YOP proteins translocation protein K (YscK); Region: YscK; pfam06578 150340005135 type III secretion system protein; Reviewed; Region: PRK06937 150340005136 Flagellar assembly protein FliH; Region: FliH; pfam02108 150340005137 Tir chaperone protein (CesT); Region: CesT; cl08444 150340005138 effector protein; Provisional; Region: PRK14052 150340005139 Tir chaperone protein (CesT); Region: CesT; cl08444 150340005140 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 150340005141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340005142 NAD(P) binding site [chemical binding]; other site 150340005143 active site 150340005144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340005145 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 150340005146 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 150340005147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 150340005148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 150340005149 Type III secretory pathway, component EscU [Intracellular trafficking and secretion]; Region: EscU; COG4792 150340005150 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 150340005151 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 150340005152 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 150340005153 FliP family; Region: FliP; cl00593 150340005154 type III secretion system protein; Validated; Region: PRK06933 150340005155 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 150340005156 type III secretion system needle length determinant; Region: type_III_yscP; TIGR02514 150340005157 Type III secretion protein YscO; Region: YscO; pfam07321 150340005158 type III secretion system ATPase; Provisional; Region: PRK06936 150340005159 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 150340005160 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 150340005161 Walker A motif/ATP binding site; other site 150340005162 Walker B motif; other site 150340005163 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 150340005164 HrpJ-like domain; Region: HrpJ; pfam07201 150340005165 TyeA; Region: TyeA; cl07611 150340005166 type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503 150340005167 Type III secretion system YscX (type_III_YscX); Region: Type_III_YscX; cl09710 150340005168 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340005169 binding surface 150340005170 TPR motif; other site 150340005171 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 150340005172 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 150340005173 Type III secretion system regulator (LcrR); Region: LcrR; cl09838 150340005174 LcrG protein; Region: LcrG; cl06311 150340005175 V antigen (LcrV) protein; Region: LcrV; pfam04792 150340005176 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 150340005177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340005178 binding surface 150340005179 TPR motif; other site 150340005180 Uncharacterized conserved protein [Function unknown]; Region: COG5613 150340005181 YopD protein; Region: YopD; pfam05844 150340005182 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 150340005183 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 150340005184 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 150340005185 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340005186 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 150340005187 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 150340005188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 150340005189 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 150340005190 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 150340005191 Transcriptional regulators [Transcription]; Region: GntR; COG1802 150340005192 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340005193 DNA-binding site [nucleotide binding]; DNA binding site 150340005194 FCD domain; Region: FCD; cl11656 150340005195 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 150340005196 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 150340005197 tetramer interface [polypeptide binding]; other site 150340005198 active site 150340005199 Mg2+/Mn2+ binding site [ion binding]; other site 150340005200 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 150340005201 dimer interface [polypeptide binding]; other site 150340005202 Citrate synthase; Region: Citrate_synt; pfam00285 150340005203 active site 150340005204 citrylCoA binding site [chemical binding]; other site 150340005205 oxalacetate/citrate binding site [chemical binding]; other site 150340005206 coenzyme A binding site [chemical binding]; other site 150340005207 catalytic triad [active] 150340005208 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 150340005209 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 150340005210 substrate binding site [chemical binding]; other site 150340005211 ligand binding site [chemical binding]; other site 150340005212 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 150340005213 substrate binding site [chemical binding]; other site 150340005214 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 150340005215 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 150340005216 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 150340005217 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 150340005218 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 150340005219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340005220 Coenzyme A binding pocket [chemical binding]; other site 150340005221 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cd00190 150340005222 cleavage site 150340005223 active site 150340005224 substrate binding sites [chemical binding]; other site 150340005225 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 150340005226 chitin/cellulose binding site [chemical binding]; other site 150340005227 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 150340005228 active site 150340005229 sugar phosphate phosphatase; Provisional; Region: PRK10513 150340005230 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 150340005231 active site 150340005232 motif I; other site 150340005233 motif II; other site 150340005234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 150340005235 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 150340005236 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 150340005237 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 150340005238 Ligand Binding Site [chemical binding]; other site 150340005239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340005240 TPR motif; other site 150340005241 binding surface 150340005242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340005243 TPR motif; other site 150340005244 binding surface 150340005245 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340005246 metal binding site [ion binding]; metal-binding site 150340005247 active site 150340005248 I-site; other site 150340005249 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 150340005250 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340005251 ligand binding site [chemical binding]; other site 150340005252 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 150340005253 Outer membrane efflux protein; Region: OEP; pfam02321 150340005254 Outer membrane efflux protein; Region: OEP; pfam02321 150340005255 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 150340005256 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 150340005257 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 150340005258 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 150340005259 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 150340005260 Calx-beta domain; Region: Calx-beta; cl02522 150340005261 Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium; plays a role in cell...; Region: CA; cl02468 150340005262 Ca2+ binding site [ion binding]; other site 150340005263 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 150340005264 metal ion-dependent adhesion site (MIDAS); other site 150340005265 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 150340005266 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340005267 ligand binding site [chemical binding]; other site 150340005268 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 150340005269 Outer membrane efflux protein; Region: OEP; pfam02321 150340005270 Outer membrane efflux protein; Region: OEP; pfam02321 150340005271 sodium/calcium exchanger 1; Region: caca; TIGR00845 150340005272 Calx-beta domain; Region: Calx-beta; cl02522 150340005273 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 150340005274 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 150340005275 PUA domain; Region: PUA; cl00607 150340005276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340005277 S-adenosylmethionine binding site [chemical binding]; other site 150340005278 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340005279 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340005280 Acylphosphatase; Region: Acylphosphatase; cl00551 150340005281 DsrC like protein; Region: DsrC; cl01101 150340005282 YccA-like proteins; Region: YccA_like; cd10433 150340005283 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 150340005284 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 150340005285 Walker A/P-loop; other site 150340005286 ATP binding site [chemical binding]; other site 150340005287 Q-loop/lid; other site 150340005288 ABC transporter signature motif; other site 150340005289 Walker B; other site 150340005290 D-loop; other site 150340005291 H-loop/switch region; other site 150340005292 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 150340005293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340005294 dimer interface [polypeptide binding]; other site 150340005295 conserved gate region; other site 150340005296 putative PBP binding loops; other site 150340005297 ABC-ATPase subunit interface; other site 150340005298 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 150340005299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 150340005300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340005301 dimer interface [polypeptide binding]; other site 150340005302 conserved gate region; other site 150340005303 putative PBP binding loops; other site 150340005304 ABC-ATPase subunit interface; other site 150340005305 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 150340005306 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 150340005307 substrate binding pocket [chemical binding]; other site 150340005308 membrane-bound complex binding site; other site 150340005309 hinge residues; other site 150340005310 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 150340005311 precorrin-2 dehydrogenase; Validated; Region: PRK06719 150340005312 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 150340005313 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 150340005314 Protein of unknown function (DUF520); Region: DUF520; cl00723 150340005315 NeuB family; Region: NeuB; cl00496 150340005316 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 150340005317 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 150340005318 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 150340005319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340005320 Uncharacterized conserved protein [Function unknown]; Region: COG3270 150340005321 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 150340005322 mce related protein; Region: MCE; pfam02470 150340005323 mce related protein; Region: MCE; pfam02470 150340005324 mce related protein; Region: MCE; pfam02470 150340005325 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 150340005326 mce related protein; Region: MCE; pfam02470 150340005327 mce related protein; Region: MCE; pfam02470 150340005328 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 150340005329 Paraquat-inducible protein A; Region: PqiA; pfam04403 150340005330 Paraquat-inducible protein A; Region: PqiA; pfam04403 150340005331 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 150340005332 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 150340005333 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340005334 Walker A/P-loop; other site 150340005335 ATP binding site [chemical binding]; other site 150340005336 Q-loop/lid; other site 150340005337 ABC transporter signature motif; other site 150340005338 Walker B; other site 150340005339 D-loop; other site 150340005340 H-loop/switch region; other site 150340005341 GAF domain; Region: GAF; cl00853 150340005342 ProP expression regulator; Provisional; Region: PRK04950 150340005343 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 150340005344 carboxy-terminal protease; Provisional; Region: PRK11186 150340005345 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 150340005346 protein binding site [polypeptide binding]; other site 150340005347 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 150340005348 Catalytic dyad [active] 150340005349 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 150340005350 aminopeptidase N; Provisional; Region: pepN; PRK14015 150340005351 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 150340005352 active site 150340005353 Zn binding site [ion binding]; other site 150340005354 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 150340005355 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 150340005356 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 150340005357 quinone interaction residues [chemical binding]; other site 150340005358 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 150340005359 active site 150340005360 catalytic residues [active] 150340005361 FMN binding site [chemical binding]; other site 150340005362 substrate binding site [chemical binding]; other site 150340005363 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 150340005364 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 150340005365 THUMP domain; Region: THUMP; cl12076 150340005366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340005367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340005368 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 150340005369 ABC transporter ATPase component; Reviewed; Region: PRK11147 150340005370 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 150340005371 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 150340005372 ABC transporter; Region: ABC_tran_2; pfam12848 150340005373 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 150340005374 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 150340005375 gammaproteobacterial enzyme C-terminal transmembrane domain; Region: gamma_C_targ; TIGR03501 150340005376 Ribosome modulation factor; Region: RMF; cl01207 150340005377 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 150340005378 active site 1 [active] 150340005379 dimer interface [polypeptide binding]; other site 150340005380 active site 2 [active] 150340005381 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 150340005382 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 150340005383 Organiser of macrodomain of Terminus of chromosome; Region: MatP; cl11476 150340005384 Protein of unknown function (DUF3634); Region: DUF3634; pfam12321 150340005385 putative transcription regulator; Region: PHA01082 150340005386 RecD/TraA family; Region: recD_rel; TIGR01448 150340005387 chromosome segregation protein; Provisional; Region: PRK03918 150340005388 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 150340005389 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 150340005390 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 150340005391 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 150340005392 Zonular occludens toxin (Zot); Region: Zot; cl01706 150340005393 minor coat protein; Region: VI; PHA00094 150340005394 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; cl15276 150340005395 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 150340005396 active site 150340005397 substrate binding site [chemical binding]; other site 150340005398 catalytic site [active] 150340005399 hypothetical protein; Region: PHA01083 150340005400 Phage related protein; Region: DUF3693; pfam12472 150340005401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340005402 dimer interface [polypeptide binding]; other site 150340005403 phosphorylation site [posttranslational modification] 150340005404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340005405 ATP binding site [chemical binding]; other site 150340005406 Mg2+ binding site [ion binding]; other site 150340005407 G-X-G motif; other site 150340005408 Response regulator receiver domain; Region: Response_reg; pfam00072 150340005409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340005410 active site 150340005411 phosphorylation site [posttranslational modification] 150340005412 intermolecular recognition site; other site 150340005413 dimerization interface [polypeptide binding]; other site 150340005414 Uncharacterized conserved protein [Function unknown]; Region: COG3287 150340005415 FIST N domain; Region: FIST; cl10701 150340005416 FIST C domain; Region: FIST_C; pfam10442 150340005417 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the...; Region: cbb3_Oxidase_I; cd01661 150340005418 Low-spin heme binding site [chemical binding]; other site 150340005419 Putative water exit pathway; other site 150340005420 Binuclear center (active site) [active] 150340005421 Putative proton exit pathway; other site 150340005422 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 150340005423 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of...; Region: cbb3_Oxidase_CcoQ; cl00282 150340005424 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 150340005425 Cytochrome c; Region: Cytochrom_C; cl11414 150340005426 Cytochrome c; Region: Cytochrom_C; cl11414 150340005427 Cytochrome c; Region: Cytochrom_C; cl11414 150340005428 FixH; Region: FixH; cl01254 150340005429 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 150340005430 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 150340005431 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 150340005432 metal-binding site [ion binding] 150340005433 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 150340005434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 150340005435 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 150340005436 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 150340005437 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 150340005438 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 150340005439 ligand binding site [chemical binding]; other site 150340005440 flexible hinge region; other site 150340005441 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 150340005442 putative switch regulator; other site 150340005443 non-specific DNA interactions [nucleotide binding]; other site 150340005444 DNA binding site [nucleotide binding] 150340005445 sequence specific DNA binding site [nucleotide binding]; other site 150340005446 putative cAMP binding site [chemical binding]; other site 150340005447 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 150340005448 Ligand Binding Site [chemical binding]; other site 150340005449 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 150340005450 Ligand Binding Site [chemical binding]; other site 150340005451 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 150340005452 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 150340005453 Ligand Binding Site [chemical binding]; other site 150340005454 Protein of unknown function (DUF2987); Region: DUF2987; pfam11205 150340005455 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 150340005456 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 150340005457 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 150340005458 Walker A/P-loop; other site 150340005459 ATP binding site [chemical binding]; other site 150340005460 Q-loop/lid; other site 150340005461 ABC transporter signature motif; other site 150340005462 Walker B; other site 150340005463 D-loop; other site 150340005464 H-loop/switch region; other site 150340005465 TOBE domain; Region: TOBE_2; cl01440 150340005466 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 150340005467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340005468 dimer interface [polypeptide binding]; other site 150340005469 conserved gate region; other site 150340005470 putative PBP binding loops; other site 150340005471 ABC-ATPase subunit interface; other site 150340005472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340005473 dimer interface [polypeptide binding]; other site 150340005474 conserved gate region; other site 150340005475 putative PBP binding loops; other site 150340005476 ABC-ATPase subunit interface; other site 150340005477 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340005478 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 150340005479 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 150340005480 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340005481 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes...; Region: SIRT5_Af1_CobB; cd01412 150340005482 NAD+ binding site [chemical binding]; other site 150340005483 substrate binding site [chemical binding]; other site 150340005484 Zn binding site [ion binding]; other site 150340005485 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 150340005486 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 150340005487 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 150340005488 RHS Repeat; Region: RHS_repeat; cl11982 150340005489 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 150340005490 RHS Repeat; Region: RHS_repeat; cl11982 150340005491 RHS protein; Region: RHS; pfam03527 150340005492 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 150340005493 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 150340005494 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 150340005495 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 150340005496 [4Fe-4S] binding site [ion binding]; other site 150340005497 molybdopterin cofactor binding site; other site 150340005498 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 150340005499 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 150340005500 molybdopterin cofactor binding site; other site 150340005501 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 150340005502 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 150340005503 Ferredoxin [Energy production and conversion]; Region: COG1146 150340005504 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 150340005505 hypothetical protein; Provisional; Region: PRK13795 150340005506 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 150340005507 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 150340005508 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 150340005509 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 150340005510 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 150340005511 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340005512 Walker A/P-loop; other site 150340005513 ATP binding site [chemical binding]; other site 150340005514 ABC transporter signature motif; other site 150340005515 Walker B; other site 150340005516 D-loop; other site 150340005517 H-loop/switch region; other site 150340005518 ABC transporter; Region: ABC_tran_2; pfam12848 150340005519 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 150340005520 two component system sensor kinase SsrA; Provisional; Region: PRK15347 150340005521 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340005522 dimer interface [polypeptide binding]; other site 150340005523 phosphorylation site [posttranslational modification] 150340005524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340005525 ATP binding site [chemical binding]; other site 150340005526 Mg2+ binding site [ion binding]; other site 150340005527 G-X-G motif; other site 150340005528 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 150340005529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340005530 active site 150340005531 phosphorylation site [posttranslational modification] 150340005532 intermolecular recognition site; other site 150340005533 dimerization interface [polypeptide binding]; other site 150340005534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340005535 Walker A motif; other site 150340005536 ATP binding site [chemical binding]; other site 150340005537 Walker B motif; other site 150340005538 arginine finger; other site 150340005539 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340005540 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 150340005541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340005542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340005543 dimer interface [polypeptide binding]; other site 150340005544 conserved gate region; other site 150340005545 putative PBP binding loops; other site 150340005546 ABC-ATPase subunit interface; other site 150340005547 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 150340005548 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 150340005549 Walker A/P-loop; other site 150340005550 ATP binding site [chemical binding]; other site 150340005551 Q-loop/lid; other site 150340005552 ABC transporter signature motif; other site 150340005553 Walker B; other site 150340005554 D-loop; other site 150340005555 H-loop/switch region; other site 150340005556 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 150340005557 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 150340005558 GTP binding site [chemical binding]; other site 150340005559 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional; Region: PRK14491 150340005560 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa...; Region: MobB; cd03116 150340005561 Walker A motif; other site 150340005562 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 150340005563 dimer interface [polypeptide binding]; other site 150340005564 putative functional site; other site 150340005565 putative MPT binding site; other site 150340005566 Protein of unknown function (DUF2960); Region: DUF2960; pfam11173 150340005567 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 150340005568 fructokinase; Reviewed; Region: PRK09557 150340005569 DTW domain; Region: DTW; cl01221 150340005570 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 150340005571 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 150340005572 nudix motif; other site 150340005573 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340005574 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340005575 NlpC/P60 family; Region: NLPC_P60; cl11438 150340005576 Protein of unknown function (DUF3802); Region: DUF3802; pfam12290 150340005577 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340005578 metal binding site [ion binding]; metal-binding site 150340005579 active site 150340005580 I-site; other site 150340005581 Response regulator receiver domain; Region: Response_reg; pfam00072 150340005582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340005583 active site 150340005584 phosphorylation site [posttranslational modification] 150340005585 intermolecular recognition site; other site 150340005586 dimerization interface [polypeptide binding]; other site 150340005587 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 150340005588 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 150340005589 Phosphotransferase enzyme family; Region: APH; pfam01636 150340005590 active site 150340005591 ATP binding site [chemical binding]; other site 150340005592 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 150340005593 Lumazine binding domain; Region: Lum_binding; pfam00677 150340005594 Lumazine binding domain; Region: Lum_binding; pfam00677 150340005595 multidrug efflux protein; Reviewed; Region: PRK01766 150340005596 MatE; Region: MatE; cl10513 150340005597 MatE; Region: MatE; cl10513 150340005598 Protein of unknown function (DUF3080); Region: DUF3080; pfam11279 150340005599 DNA ligase; Provisional; Region: PRK09125 150340005600 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 150340005601 DNA binding site [nucleotide binding] 150340005602 active site 150340005603 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 150340005604 DNA binding site [nucleotide binding] 150340005605 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 150340005606 anti sigma factor interaction site; other site 150340005607 regulatory phosphorylation site [posttranslational modification]; other site 150340005608 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340005609 ligand binding site [chemical binding]; other site 150340005610 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 150340005611 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 150340005612 SLBB domain; Region: SLBB; pfam10531 150340005613 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 150340005614 SLBB domain; Region: SLBB; pfam10531 150340005615 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 150340005616 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 150340005617 SLBB domain; Region: SLBB; pfam10531 150340005618 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 150340005619 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 150340005620 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 150340005621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340005622 active site 150340005623 phosphorylation site [posttranslational modification] 150340005624 intermolecular recognition site; other site 150340005625 dimerization interface [polypeptide binding]; other site 150340005626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340005627 Walker A motif; other site 150340005628 ATP binding site [chemical binding]; other site 150340005629 Walker B motif; other site 150340005630 arginine finger; other site 150340005631 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340005632 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 150340005633 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 150340005634 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 150340005635 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 150340005636 putative ADP-binding pocket [chemical binding]; other site 150340005637 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 150340005638 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 150340005639 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 150340005640 O-Antigen ligase; Region: Wzy_C; cl04850 150340005641 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 150340005642 putative homodimer interface [polypeptide binding]; other site 150340005643 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 150340005644 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 150340005645 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 150340005646 putative ADP-binding pocket [chemical binding]; other site 150340005647 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 150340005648 DXD motif; other site 150340005649 Bacterial sugar transferase; Region: Bac_transf; cl00939 150340005650 Predicted kinase [General function prediction only]; Region: COG0645 150340005651 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340005652 Active site [active] 150340005653 BCCT family transporter; Region: BCCT; cl00569 150340005654 Surface antigen; Region: Surface_Ag_2; cl01155 150340005655 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 150340005656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 150340005657 ATP binding site [chemical binding]; other site 150340005658 putative Mg++ binding site [ion binding]; other site 150340005659 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340005660 nucleotide binding region [chemical binding]; other site 150340005661 ATP-binding site [chemical binding]; other site 150340005662 Helicase associated domain (HA2); Region: HA2; cl04503 150340005663 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 150340005664 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 150340005665 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 150340005666 MltA-interacting protein MipA; Region: MipA; cl01504 150340005667 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 150340005668 metal binding site [ion binding]; metal-binding site 150340005669 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 150340005670 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 150340005671 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 150340005672 putative metal binding site [ion binding]; other site 150340005673 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 150340005674 active site 150340005675 substrate binding site [chemical binding]; other site 150340005676 catalytic site [active] 150340005677 CHASE domain; Region: CHASE; cl01369 150340005678 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340005679 metal binding site [ion binding]; metal-binding site 150340005680 active site 150340005681 I-site; other site 150340005682 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 150340005683 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 150340005684 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 150340005685 DNA-K related protein; Region: DUF3731; pfam12531 150340005686 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 150340005687 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 150340005688 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 150340005689 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 150340005690 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 150340005691 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 150340005692 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340005693 Walker A/P-loop; other site 150340005694 ATP binding site [chemical binding]; other site 150340005695 Q-loop/lid; other site 150340005696 ABC transporter signature motif; other site 150340005697 Walker B; other site 150340005698 D-loop; other site 150340005699 H-loop/switch region; other site 150340005700 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 150340005701 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 150340005702 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340005703 Walker A/P-loop; other site 150340005704 ATP binding site [chemical binding]; other site 150340005705 Q-loop/lid; other site 150340005706 ABC transporter signature motif; other site 150340005707 Walker B; other site 150340005708 D-loop; other site 150340005709 H-loop/switch region; other site 150340005710 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 150340005711 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 150340005712 N-terminal plug; other site 150340005713 ligand-binding site [chemical binding]; other site 150340005714 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 150340005715 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 150340005716 ABC-ATPase subunit interface; other site 150340005717 dimer interface [polypeptide binding]; other site 150340005718 putative PBP binding regions; other site 150340005719 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 150340005720 ABC-ATPase subunit interface; other site 150340005721 dimer interface [polypeptide binding]; other site 150340005722 putative PBP binding regions; other site 150340005723 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 150340005724 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 150340005725 siderophore binding site; other site 150340005726 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 150340005727 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 150340005728 Walker A/P-loop; other site 150340005729 ATP binding site [chemical binding]; other site 150340005730 Q-loop/lid; other site 150340005731 ABC transporter signature motif; other site 150340005732 Walker B; other site 150340005733 D-loop; other site 150340005734 H-loop/switch region; other site 150340005735 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 150340005736 Zn2+ binding site [ion binding]; other site 150340005737 Mg2+ binding site [ion binding]; other site 150340005738 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 150340005739 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 150340005740 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 150340005741 putative active site [active] 150340005742 metal binding site [ion binding]; metal-binding site 150340005743 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 150340005744 Zn2+ binding site [ion binding]; other site 150340005745 Mg2+ binding site [ion binding]; other site 150340005746 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 150340005747 Zn2+ binding site [ion binding]; other site 150340005748 Mg2+ binding site [ion binding]; other site 150340005749 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 150340005750 Integral membrane protein TerC family; Region: TerC; cl10468 150340005751 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340005752 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 150340005753 substrate binding pocket [chemical binding]; other site 150340005754 dimerization interface [polypeptide binding]; other site 150340005755 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 150340005756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 150340005757 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 150340005758 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 150340005759 FeS/SAM binding site; other site 150340005760 hypothetical protein; Provisional; Region: PRK10977 150340005761 Glycine radical; Region: Gly_radical; cl12026 150340005762 LysE type translocator; Region: LysE; cl00565 150340005763 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 150340005764 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 150340005765 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 150340005766 Zn2+ binding site [ion binding]; other site 150340005767 Mg2+ binding site [ion binding]; other site 150340005768 PAS domain S-box; Region: sensory_box; TIGR00229 150340005769 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340005770 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340005771 metal binding site [ion binding]; metal-binding site 150340005772 active site 150340005773 I-site; other site 150340005774 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340005775 Response regulator receiver domain; Region: Response_reg; pfam00072 150340005776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340005777 active site 150340005778 phosphorylation site [posttranslational modification] 150340005779 intermolecular recognition site; other site 150340005780 dimerization interface [polypeptide binding]; other site 150340005781 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 150340005782 ligand binding site [chemical binding]; other site 150340005783 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 150340005784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340005785 ATP binding site [chemical binding]; other site 150340005786 Mg2+ binding site [ion binding]; other site 150340005787 G-X-G motif; other site 150340005788 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 150340005789 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 150340005790 transmembrane helices; other site 150340005791 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 150340005792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340005793 Coenzyme A binding pocket [chemical binding]; other site 150340005794 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 150340005795 Cache domain; Region: Cache_1; pfam02743 150340005796 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340005797 metal binding site [ion binding]; metal-binding site 150340005798 active site 150340005799 I-site; other site 150340005800 Domain of unknown function (DUF336); Region: DUF336; cl01249 150340005801 putative oxidoreductase; Provisional; Region: PRK11579 150340005802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340005803 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 150340005804 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 150340005805 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340005806 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 150340005807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 150340005808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340005809 binding surface 150340005810 TPR motif; other site 150340005811 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 150340005812 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 150340005813 FeS/SAM binding site; other site 150340005814 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 150340005815 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 150340005816 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 150340005817 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 150340005818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340005819 binding surface 150340005820 TPR motif; other site 150340005821 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 150340005822 Sulfatase; Region: Sulfatase; cl10460 150340005823 aspartate kinase; Validated; Region: PRK09181 150340005824 AAK_AK-Ectoine: Amino Acid Kinase Superfamily (AAK), AK-Ectoine; this CD includes the N-terminal catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway found in Methylomicrobium...; Region: AAK_AK-Ectoine; cd04248 150340005825 putative catalytic residues [active] 150340005826 putative nucleotide binding site [chemical binding]; other site 150340005827 putative aspartate binding site [chemical binding]; other site 150340005828 ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_1; cd04910 150340005829 allosteric regulatory residue; other site 150340005830 ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_2; cd04915 150340005831 Cupin domain; Region: Cupin_2; cl09118 150340005832 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 150340005833 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 150340005834 inhibitor-cofactor binding pocket; inhibition site 150340005835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340005836 catalytic residue [active] 150340005837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340005838 Coenzyme A binding pocket [chemical binding]; other site 150340005839 BCCT family transporter; Region: BCCT; cl00569 150340005840 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 150340005841 active site 150340005842 substrate binding site [chemical binding]; other site 150340005843 catalytic site [active] 150340005844 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 150340005845 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 150340005846 ligand binding site [chemical binding]; other site 150340005847 flexible hinge region; other site 150340005848 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain...; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 150340005849 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 150340005850 metal binding triad; other site 150340005851 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 150340005852 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 150340005853 Walker A/P-loop; other site 150340005854 ATP binding site [chemical binding]; other site 150340005855 Q-loop/lid; other site 150340005856 ABC transporter signature motif; other site 150340005857 Walker B; other site 150340005858 D-loop; other site 150340005859 H-loop/switch region; other site 150340005860 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 150340005861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340005862 dimer interface [polypeptide binding]; other site 150340005863 conserved gate region; other site 150340005864 putative PBP binding loops; other site 150340005865 ABC-ATPase subunit interface; other site 150340005866 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 150340005867 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 150340005868 Thermostable hemolysin; Region: T_hemolysin; pfam12261 150340005869 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 150340005870 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 150340005871 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 150340005872 heme binding pocket [chemical binding]; other site 150340005873 heme ligand [chemical binding]; other site 150340005874 classical (c) SDRs; Region: SDR_c; cd05233 150340005875 NAD(P) binding site [chemical binding]; other site 150340005876 active site 150340005877 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 150340005878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 150340005879 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 150340005880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340005881 active site 150340005882 phosphorylation site [posttranslational modification] 150340005883 intermolecular recognition site; other site 150340005884 dimerization interface [polypeptide binding]; other site 150340005885 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340005886 DNA binding site [nucleotide binding] 150340005887 sensor protein QseC; Provisional; Region: PRK10337 150340005888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340005889 dimer interface [polypeptide binding]; other site 150340005890 phosphorylation site [posttranslational modification] 150340005891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340005892 ATP binding site [chemical binding]; other site 150340005893 Mg2+ binding site [ion binding]; other site 150340005894 G-X-G motif; other site 150340005895 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 150340005896 Sulfatase; Region: Sulfatase; cl10460 150340005897 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 150340005898 putative dimer interface [polypeptide binding]; other site 150340005899 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 150340005900 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 150340005901 LysE type translocator; Region: LysE; cl00565 150340005902 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 150340005903 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 150340005904 active site 150340005905 Zn binding site [ion binding]; other site 150340005906 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 150340005907 putative acyl-acceptor binding pocket; other site 150340005908 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 150340005909 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 150340005910 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 150340005911 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 150340005912 proposed active site lysine [active] 150340005913 conserved cys residue [active] 150340005914 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 150340005915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340005916 binding surface 150340005917 TPR motif; other site 150340005918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340005919 binding surface 150340005920 TPR motif; other site 150340005921 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 150340005922 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340005923 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340005924 metal binding site [ion binding]; metal-binding site 150340005925 active site 150340005926 I-site; other site 150340005927 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340005928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340005929 dimer interface [polypeptide binding]; other site 150340005930 two-component VirA-like sensor kinase; Provisional; Region: PRK13837 150340005931 phosphorylation site [posttranslational modification] 150340005932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340005933 ATP binding site [chemical binding]; other site 150340005934 Mg2+ binding site [ion binding]; other site 150340005935 G-X-G motif; other site 150340005936 Response regulator receiver domain; Region: Response_reg; pfam00072 150340005937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340005938 active site 150340005939 phosphorylation site [posttranslational modification] 150340005940 intermolecular recognition site; other site 150340005941 dimerization interface [polypeptide binding]; other site 150340005942 Response regulator receiver domain; Region: Response_reg; pfam00072 150340005943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340005944 active site 150340005945 phosphorylation site [posttranslational modification] 150340005946 intermolecular recognition site; other site 150340005947 dimerization interface [polypeptide binding]; other site 150340005948 maltose O-acetyltransferase; Provisional; Region: PRK10092 150340005949 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 150340005950 active site 150340005951 substrate binding site [chemical binding]; other site 150340005952 trimer interface [polypeptide binding]; other site 150340005953 CoA binding site [chemical binding]; other site 150340005954 Protein of unknown function (DUF962); Region: DUF962; cl01879 150340005955 Protein of unknown function (DUF419); Region: DUF419; cl15265 150340005956 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340005957 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 150340005958 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 150340005959 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340005960 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 150340005961 Flagellin N-methylase; Region: FliB; cl00497 150340005962 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 150340005963 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 150340005964 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens...; Region: GST_N_Zeta; cd03042 150340005965 maleylacetoacetate isomerase; Region: maiA; TIGR01262 150340005966 C-terminal domain interface [polypeptide binding]; other site 150340005967 GSH binding site (G-site) [chemical binding]; other site 150340005968 putative dimer interface [polypeptide binding]; other site 150340005969 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 150340005970 dimer interface [polypeptide binding]; other site 150340005971 N-terminal domain interface [polypeptide binding]; other site 150340005972 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 150340005973 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 150340005974 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 150340005975 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 150340005976 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 150340005977 dimer interface [polypeptide binding]; other site 150340005978 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 150340005979 active site 150340005980 Fe binding site [ion binding]; other site 150340005981 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 150340005982 peptidase T-like protein; Region: PepT-like; TIGR01883 150340005983 metal binding site [ion binding]; metal-binding site 150340005984 putative dimer interface [polypeptide binding]; other site 150340005985 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 150340005986 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 150340005987 peptide binding site [polypeptide binding]; other site 150340005988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340005989 dimer interface [polypeptide binding]; other site 150340005990 conserved gate region; other site 150340005991 putative PBP binding loops; other site 150340005992 ABC-ATPase subunit interface; other site 150340005993 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 150340005994 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 150340005995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340005996 dimer interface [polypeptide binding]; other site 150340005997 conserved gate region; other site 150340005998 putative PBP binding loops; other site 150340005999 ABC-ATPase subunit interface; other site 150340006000 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 150340006001 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340006002 Walker A/P-loop; other site 150340006003 ATP binding site [chemical binding]; other site 150340006004 Q-loop/lid; other site 150340006005 ABC transporter signature motif; other site 150340006006 Walker B; other site 150340006007 D-loop; other site 150340006008 H-loop/switch region; other site 150340006009 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 150340006010 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 150340006011 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340006012 Walker A/P-loop; other site 150340006013 ATP binding site [chemical binding]; other site 150340006014 Q-loop/lid; other site 150340006015 ABC transporter signature motif; other site 150340006016 Walker B; other site 150340006017 D-loop; other site 150340006018 H-loop/switch region; other site 150340006019 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 150340006020 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 150340006021 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 150340006022 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline...; Region: APP; cd01085 150340006023 active site 150340006024 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 150340006025 Collagenase; Region: Peptidase_M9; pfam01752 150340006026 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 150340006027 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 150340006028 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 150340006029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340006030 dimer interface [polypeptide binding]; other site 150340006031 conserved gate region; other site 150340006032 putative PBP binding loops; other site 150340006033 ABC-ATPase subunit interface; other site 150340006034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340006035 dimer interface [polypeptide binding]; other site 150340006036 conserved gate region; other site 150340006037 putative PBP binding loops; other site 150340006038 ABC-ATPase subunit interface; other site 150340006039 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 150340006040 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 150340006041 Walker A/P-loop; other site 150340006042 ATP binding site [chemical binding]; other site 150340006043 Q-loop/lid; other site 150340006044 ABC transporter signature motif; other site 150340006045 Walker B; other site 150340006046 D-loop; other site 150340006047 H-loop/switch region; other site 150340006048 TOBE domain; Region: TOBE_2; cl01440 150340006049 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 150340006050 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 150340006051 inhibitor site; inhibition site 150340006052 active site 150340006053 dimer interface [polypeptide binding]; other site 150340006054 catalytic residue [active] 150340006055 ornithine cyclodeaminase; Validated; Region: PRK06141 150340006056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340006057 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 150340006058 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 150340006059 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 150340006060 Proline racemase; Region: Pro_racemase; pfam05544 150340006061 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 150340006062 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 150340006063 dimer interface [polypeptide binding]; other site 150340006064 NADP binding site [chemical binding]; other site 150340006065 catalytic residues [active] 150340006066 Transcriptional regulators [Transcription]; Region: GntR; COG1802 150340006067 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340006068 DNA-binding site [nucleotide binding]; DNA binding site 150340006069 FCD domain; Region: FCD; cl11656 150340006070 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 150340006071 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117 150340006072 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 150340006073 Catalytic dyad [active] 150340006074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340006075 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 150340006076 Protein of unknown function DUF45; Region: DUF45; cl00636 150340006077 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 150340006078 catalytic residues [active] 150340006079 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 150340006080 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340006081 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 150340006082 dimerization interface [polypeptide binding]; other site 150340006083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340006084 Major Facilitator Superfamily; Region: MFS_1; pfam07690 150340006085 putative substrate translocation pore; other site 150340006086 Protein of unknown function (DUF1415); Region: DUF1415; cl01301 150340006087 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 150340006088 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 150340006089 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 150340006090 Walker A/P-loop; other site 150340006091 ATP binding site [chemical binding]; other site 150340006092 Q-loop/lid; other site 150340006093 ABC transporter signature motif; other site 150340006094 Walker B; other site 150340006095 D-loop; other site 150340006096 H-loop/switch region; other site 150340006097 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 150340006098 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 150340006099 ABC-ATPase subunit interface; other site 150340006100 dimer interface [polypeptide binding]; other site 150340006101 putative PBP binding regions; other site 150340006102 Peptidase M14 Succinylglutamate desuccinylase (ASTE, also known as N-succinyl-L-glutamate amidohydrolase, N2-succinylglutamate desuccinylase, and SGDS; EC 3.5.1.96) belongs to the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily...; Region: M14_ASTE; cd03855 150340006103 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 150340006104 putative active site [active] 150340006105 Zn-binding site [ion binding]; other site 150340006106 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 150340006107 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 150340006108 active site 150340006109 Zn binding site [ion binding]; other site 150340006110 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 150340006111 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 150340006112 catalytic core [active] 150340006113 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 150340006114 homotrimer interface [polypeptide binding]; other site 150340006115 Walker A motif; other site 150340006116 GTP binding site [chemical binding]; other site 150340006117 Walker B motif; other site 150340006118 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 150340006119 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 150340006120 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 150340006121 putative dimer interface [polypeptide binding]; other site 150340006122 active site pocket [active] 150340006123 putative cataytic base [active] 150340006124 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 150340006125 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 150340006126 NAD binding site [chemical binding]; other site 150340006127 active site 150340006128 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 150340006129 exonuclease I; Provisional; Region: sbcB; PRK11779 150340006130 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 150340006131 active site 150340006132 substrate binding site [chemical binding]; other site 150340006133 catalytic site [active] 150340006134 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 150340006135 LrgA family; Region: LrgA; cl00608 150340006136 LrgB-like family; Region: LrgB; cl00596 150340006137 cytidine deaminase; Provisional; Region: PRK09027 150340006138 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 150340006139 active site 150340006140 catalytic motif [active] 150340006141 Zn binding site [ion binding]; other site 150340006142 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 150340006143 active site 150340006144 catalytic motif [active] 150340006145 Zn binding site [ion binding]; other site 150340006146 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 150340006147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340006148 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 150340006149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340006150 Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins; Region: NT_Pol-beta-like; cl11966 150340006151 metal binding triad [ion binding]; metal-binding site 150340006152 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 150340006153 IHF dimer interface [polypeptide binding]; other site 150340006154 IHF - DNA interface [nucleotide binding]; other site 150340006155 Membrane transport protein; Region: Mem_trans; cl09117 150340006156 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 150340006157 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 150340006158 putative tRNA-binding site [nucleotide binding]; other site 150340006159 B3/4 domain; Region: B3_4; cl11458 150340006160 tRNA synthetase B5 domain; Region: B5; cl08394 150340006161 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 150340006162 dimer interface [polypeptide binding]; other site 150340006163 motif 1; other site 150340006164 motif 3; other site 150340006165 motif 2; other site 150340006166 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 150340006167 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 150340006168 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 150340006169 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 150340006170 dimer interface [polypeptide binding]; other site 150340006171 motif 1; other site 150340006172 active site 150340006173 motif 2; other site 150340006174 motif 3; other site 150340006175 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 150340006176 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 150340006177 Protein export membrane protein; Region: SecD_SecF; cl14618 150340006178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 150340006179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 150340006180 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 150340006181 Domain of unknown function (DUF74); Region: DUF74; cl00426 150340006182 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 150340006183 23S rRNA binding site [nucleotide binding]; other site 150340006184 L21 binding site [polypeptide binding]; other site 150340006185 L13 binding site [polypeptide binding]; other site 150340006186 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 150340006187 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 150340006188 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 150340006189 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 150340006190 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 150340006191 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 150340006192 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 150340006193 active site 150340006194 dimer interface [polypeptide binding]; other site 150340006195 motif 1; other site 150340006196 motif 2; other site 150340006197 motif 3; other site 150340006198 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 150340006199 anticodon binding site; other site 150340006200 Protein of unknown function (DUF3187); Region: DUF3187; pfam11383 150340006201 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 150340006202 SpoOM protein; Region: Spo0M; pfam07070 150340006203 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 150340006204 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340006205 DNA-binding site [nucleotide binding]; DNA binding site 150340006206 UTRA domain; Region: UTRA; cl01230 150340006207 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 150340006208 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 150340006209 active site 150340006210 Arginase family; Region: Arginase; cl00306 150340006211 urocanate hydratase; Provisional; Region: PRK05414 150340006212 urocanate hydratase; Region: hutU; TIGR01228 150340006213 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 150340006214 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 150340006215 active sites [active] 150340006216 tetramer interface [polypeptide binding]; other site 150340006217 Protein of unknown function (DUF3581); Region: DUF3581; pfam12119 150340006218 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 150340006219 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 150340006220 FAD binding domain; Region: FAD_binding_4; pfam01565 150340006221 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 150340006222 Protein of unknown function (DUF3334); Region: DUF3334; pfam11813 150340006223 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 150340006224 putative outer membrane lipoprotein; Provisional; Region: PRK10510 150340006225 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340006226 ligand binding site [chemical binding]; other site 150340006227 proteasome-activating nucleotidase; Provisional; Region: PRK03992 150340006228 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 150340006229 Cell division inhibitor SulA; Region: SulA; cl01880 150340006230 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 150340006231 ATP binding site [chemical binding]; other site 150340006232 active site 150340006233 substrate binding site [chemical binding]; other site 150340006234 PhoD-like phosphatase; Region: PhoD; pfam09423 150340006235 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 150340006236 putative active site [active] 150340006237 putative metal binding site [ion binding]; other site 150340006238 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 150340006239 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 150340006240 ATP binding site [chemical binding]; other site 150340006241 putative Mg++ binding site [ion binding]; other site 150340006242 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340006243 nucleotide binding region [chemical binding]; other site 150340006244 ATP-binding site [chemical binding]; other site 150340006245 Helicase associated domain (HA2); Region: HA2; cl04503 150340006246 malate dehydrogenase; Provisional; Region: PRK13529 150340006247 Malic enzyme, N-terminal domain; Region: malic; pfam00390 150340006248 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 150340006249 NAD(P) binding site [chemical binding]; other site 150340006250 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 150340006251 putative active site [active] 150340006252 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 150340006253 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 150340006254 transmembrane helices; other site 150340006255 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340006256 metal binding site [ion binding]; metal-binding site 150340006257 active site 150340006258 I-site; other site 150340006259 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 150340006260 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 150340006261 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 150340006262 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 150340006263 catalytic residue [active] 150340006264 Uncharacterized protein conserved in bacteria (DUF2257); Region: DUF2257; cl01794 150340006265 thioredoxin reductase; Provisional; Region: PRK10262 150340006266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340006267 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 150340006268 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 150340006269 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340006270 Walker A/P-loop; other site 150340006271 ATP binding site [chemical binding]; other site 150340006272 Q-loop/lid; other site 150340006273 ABC transporter signature motif; other site 150340006274 Walker B; other site 150340006275 D-loop; other site 150340006276 H-loop/switch region; other site 150340006277 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 150340006278 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 150340006279 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340006280 Walker A/P-loop; other site 150340006281 ATP binding site [chemical binding]; other site 150340006282 Q-loop/lid; other site 150340006283 ABC transporter signature motif; other site 150340006284 Walker B; other site 150340006285 D-loop; other site 150340006286 H-loop/switch region; other site 150340006287 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 150340006288 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 150340006289 catalytic residue [active] 150340006290 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active...; Region: PSAT_like; cd00611 150340006291 homodimer interface [polypeptide binding]; other site 150340006292 substrate-cofactor binding pocket; other site 150340006293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340006294 catalytic residue [active] 150340006295 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 150340006296 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 150340006297 ligand binding site [chemical binding]; other site 150340006298 flexible hinge region; other site 150340006299 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 150340006300 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340006301 dimer interface [polypeptide binding]; other site 150340006302 phosphorylation site [posttranslational modification] 150340006303 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 150340006304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340006305 ATP binding site [chemical binding]; other site 150340006306 Mg2+ binding site [ion binding]; other site 150340006307 G-X-G motif; other site 150340006308 Response regulator receiver domain; Region: Response_reg; pfam00072 150340006309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340006310 active site 150340006311 phosphorylation site [posttranslational modification] 150340006312 intermolecular recognition site; other site 150340006313 dimerization interface [polypeptide binding]; other site 150340006314 TfoX N-terminal domain; Region: TfoX_N; cl01167 150340006315 TfoX N-terminal domain; Region: TfoX_N; cl01167 150340006316 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 150340006317 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 150340006318 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 150340006319 glutaredoxin 2; Provisional; Region: PRK10387 150340006320 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 150340006321 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 150340006322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 150340006323 catalytic residue [active] 150340006324 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 150340006325 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 150340006326 putative active site [active] 150340006327 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 150340006328 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 150340006329 putative active site [active] 150340006330 metal binding site [ion binding]; metal-binding site 150340006331 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 150340006332 GSH binding site [chemical binding]; other site 150340006333 catalytic residues [active] 150340006334 putative transporter; Provisional; Region: PRK04972 150340006335 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 150340006336 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340006337 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340006338 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 150340006339 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 150340006340 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 150340006341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340006342 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 150340006343 acyl-CoA dehydrogenase; Reviewed; Region: PRK13026 150340006344 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 150340006345 active site 150340006346 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 150340006347 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 150340006348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 150340006349 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 150340006350 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 150340006351 FtsX-like permease family; Region: FtsX; pfam02687 150340006352 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 150340006353 FtsX-like permease family; Region: FtsX; pfam02687 150340006354 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 150340006355 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 150340006356 Walker A/P-loop; other site 150340006357 ATP binding site [chemical binding]; other site 150340006358 Q-loop/lid; other site 150340006359 ABC transporter signature motif; other site 150340006360 Walker B; other site 150340006361 D-loop; other site 150340006362 H-loop/switch region; other site 150340006363 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 150340006364 MatE; Region: MatE; cl10513 150340006365 MatE; Region: MatE; cl10513 150340006366 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 150340006367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340006368 NAD(P) binding site [chemical binding]; other site 150340006369 active site 150340006370 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 150340006371 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl09485 150340006372 Cytochrome c; Region: Cytochrom_C; cl11414 150340006373 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 150340006374 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 150340006375 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 150340006376 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 150340006377 Protein of unknown function (DUF3374); Region: DUF3374; cl11904 150340006378 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 150340006379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340006380 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 150340006381 putative substrate translocation pore; other site 150340006382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340006383 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 150340006384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 150340006385 RNA binding surface [nucleotide binding]; other site 150340006386 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 150340006387 active site 150340006388 uracil binding [chemical binding]; other site 150340006389 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 150340006390 ATP binding site [chemical binding]; other site 150340006391 putative Mg++ binding site [ion binding]; other site 150340006392 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340006393 nucleotide binding region [chemical binding]; other site 150340006394 ATP-binding site [chemical binding]; other site 150340006395 Double zinc ribbon; Region: DZR; pfam12773 150340006396 Predicted membrane protein [Function unknown]; Region: COG3212 150340006397 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 150340006398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340006399 active site 150340006400 phosphorylation site [posttranslational modification] 150340006401 intermolecular recognition site; other site 150340006402 dimerization interface [polypeptide binding]; other site 150340006403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340006404 DNA binding site [nucleotide binding] 150340006405 sensor protein PhoQ; Provisional; Region: PRK10815 150340006406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340006407 ATP binding site [chemical binding]; other site 150340006408 Mg2+ binding site [ion binding]; other site 150340006409 G-X-G motif; other site 150340006410 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 150340006411 5S rRNA interface [nucleotide binding]; other site 150340006412 CTC domain interface [polypeptide binding]; other site 150340006413 L16 interface [polypeptide binding]; other site 150340006414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340006415 Coenzyme A binding pocket [chemical binding]; other site 150340006416 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 150340006417 active site 150340006418 metal binding site [ion binding]; metal-binding site 150340006419 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 150340006420 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 150340006421 META domain; Region: META; cl01245 150340006422 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340006423 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 150340006424 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 150340006425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 150340006426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340006427 dimer interface [polypeptide binding]; other site 150340006428 conserved gate region; other site 150340006429 putative PBP binding loops; other site 150340006430 ABC-ATPase subunit interface; other site 150340006431 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 150340006432 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340006433 Walker A/P-loop; other site 150340006434 ATP binding site [chemical binding]; other site 150340006435 Q-loop/lid; other site 150340006436 ABC transporter signature motif; other site 150340006437 Walker B; other site 150340006438 D-loop; other site 150340006439 H-loop/switch region; other site 150340006440 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 150340006441 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 150340006442 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 150340006443 GAF domain; Region: GAF; cl00853 150340006444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340006445 Walker A motif; other site 150340006446 ATP binding site [chemical binding]; other site 150340006447 Walker B motif; other site 150340006448 arginine finger; other site 150340006449 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340006450 hybrid cluster protein; Provisional; Region: PRK05290 150340006451 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 150340006452 ACS interaction site; other site 150340006453 CODH interaction site; other site 150340006454 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 150340006455 hybrid metal cluster; other site 150340006456 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 150340006457 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 150340006458 FAD binding pocket [chemical binding]; other site 150340006459 FAD binding motif [chemical binding]; other site 150340006460 phosphate binding motif [ion binding]; other site 150340006461 beta-alpha-beta structure motif; other site 150340006462 NAD binding pocket [chemical binding]; other site 150340006463 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 150340006464 catalytic loop [active] 150340006465 iron binding site [ion binding]; other site 150340006466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340006467 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 150340006468 active site 150340006469 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 150340006470 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 150340006471 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 150340006472 putative active site [active] 150340006473 catalytic site [active] 150340006474 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 150340006475 putative active site [active] 150340006476 catalytic site [active] 150340006477 cystathionine beta-lyase; Provisional; Region: PRK09028 150340006478 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 150340006479 homodimer interface [polypeptide binding]; other site 150340006480 substrate-cofactor binding pocket; other site 150340006481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340006482 catalytic residue [active] 150340006483 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 150340006484 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 150340006485 lipase chaperone; Provisional; Region: PRK01294 150340006486 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 150340006487 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 150340006488 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 150340006489 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 150340006490 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 150340006491 PspC domain; Region: PspC; cl00864 150340006492 phage shock protein C; Region: phageshock_pspC; TIGR02978 150340006493 Phage shock protein B; Region: PspB; cl05946 150340006494 phage shock protein PspA; Provisional; Region: PRK10698 150340006495 phage shock protein A; Region: phageshock_pspA; TIGR02977 150340006496 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 150340006497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340006498 Walker A motif; other site 150340006499 ATP binding site [chemical binding]; other site 150340006500 Walker B motif; other site 150340006501 arginine finger; other site 150340006502 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 150340006503 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 150340006504 peptide binding site [polypeptide binding]; other site 150340006505 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168 150340006506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340006507 dimer interface [polypeptide binding]; other site 150340006508 conserved gate region; other site 150340006509 putative PBP binding loops; other site 150340006510 ABC-ATPase subunit interface; other site 150340006511 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 150340006512 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 150340006513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340006514 dimer interface [polypeptide binding]; other site 150340006515 conserved gate region; other site 150340006516 putative PBP binding loops; other site 150340006517 ABC-ATPase subunit interface; other site 150340006518 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170 150340006519 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340006520 Walker A/P-loop; other site 150340006521 ATP binding site [chemical binding]; other site 150340006522 Q-loop/lid; other site 150340006523 ABC transporter signature motif; other site 150340006524 Walker B; other site 150340006525 D-loop; other site 150340006526 H-loop/switch region; other site 150340006527 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 150340006528 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 150340006529 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340006530 Walker A/P-loop; other site 150340006531 ATP binding site [chemical binding]; other site 150340006532 Q-loop/lid; other site 150340006533 ABC transporter signature motif; other site 150340006534 Walker B; other site 150340006535 D-loop; other site 150340006536 H-loop/switch region; other site 150340006537 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 150340006538 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 150340006539 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 150340006540 DHHA2 domain; Region: DHHA2; pfam02833 150340006541 Protein of unknown function (DUF2899); Region: DUF2899; pfam11449 150340006542 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 150340006543 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 150340006544 catalytic site [active] 150340006545 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 150340006546 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 150340006547 molybdopterin cofactor binding site [chemical binding]; other site 150340006548 substrate binding site [chemical binding]; other site 150340006549 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 150340006550 molybdopterin cofactor binding site; other site 150340006551 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 150340006552 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl09485 150340006553 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 150340006554 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 150340006555 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 150340006556 Phosphate-starvation-inducible E; Region: PsiE; cl01264 150340006557 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 150340006558 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 150340006559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340006560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340006561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 150340006562 dimerization interface [polypeptide binding]; other site 150340006563 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 150340006564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340006565 NAD(P) binding site [chemical binding]; other site 150340006566 active site 150340006567 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 150340006568 putative active site [active] 150340006569 Thymidine kinase; Region: TK; cl00631 150340006570 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 150340006571 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 150340006572 active site 150340006573 HIGH motif; other site 150340006574 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 150340006575 KMSKS motif; other site 150340006576 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 150340006577 tRNA binding surface [nucleotide binding]; other site 150340006578 anticodon binding site; other site 150340006579 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 150340006580 substrate binding site [chemical binding]; other site 150340006581 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 150340006582 putative active site [active] 150340006583 putative metal binding site [ion binding]; other site 150340006584 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 150340006585 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340006586 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 150340006587 hypothetical protein; Provisional; Region: PRK02250 150340006588 SEC-C motif; Region: SEC-C; cl12132 150340006589 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 150340006590 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 150340006591 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 150340006592 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 150340006593 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 150340006594 substrate binding site [chemical binding]; other site 150340006595 glutamase interaction surface [polypeptide binding]; other site 150340006596 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 150340006597 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 150340006598 catalytic residues [active] 150340006599 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 150340006600 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 150340006601 putative active site [active] 150340006602 oxyanion strand; other site 150340006603 catalytic triad [active] 150340006604 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 150340006605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 150340006606 active site 150340006607 motif I; other site 150340006608 motif II; other site 150340006609 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 150340006610 putative active site pocket [active] 150340006611 4-fold oligomerization interface [polypeptide binding]; other site 150340006612 metal binding residues [ion binding]; metal-binding site 150340006613 3-fold/trimer interface [polypeptide binding]; other site 150340006614 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 150340006615 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 150340006616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340006617 homodimer interface [polypeptide binding]; other site 150340006618 catalytic residue [active] 150340006619 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 150340006620 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 150340006621 NAD binding site [chemical binding]; other site 150340006622 dimerization interface [polypeptide binding]; other site 150340006623 product binding site; other site 150340006624 substrate binding site [chemical binding]; other site 150340006625 zinc binding site [ion binding]; other site 150340006626 catalytic residues [active] 150340006627 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 150340006628 ATP phosphoribosyltransferase; Region: HisG; cl15266 150340006629 HisG, C-terminal domain; Region: HisG_C; cl06867 150340006630 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 150340006631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340006632 Walker A motif; other site 150340006633 ATP binding site [chemical binding]; other site 150340006634 Walker B motif; other site 150340006635 arginine finger; other site 150340006636 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340006637 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340006638 Domain in histone-like proteins of HNS family; Region: HNS; cl09251 150340006639 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 150340006640 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 150340006641 substrate binding site [chemical binding]; other site 150340006642 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 150340006643 ATP binding site [chemical binding]; other site 150340006644 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 150340006645 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 150340006646 Protein of unknown function (DUF489); Region: DUF489; cl01097 150340006647 adenylosuccinate lyase; Provisional; Region: PRK09285 150340006648 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 150340006649 tetramer interface [polypeptide binding]; other site 150340006650 active site 150340006651 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 150340006652 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 150340006653 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 150340006654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340006655 S-adenosylmethionine binding site [chemical binding]; other site 150340006656 Protein of unknown function (DUF1365); Region: DUF1365; cl01388 150340006657 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 150340006658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340006659 short chain dehydrogenase; Provisional; Region: PRK06101 150340006660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340006661 NAD(P) binding site [chemical binding]; other site 150340006662 active site 150340006663 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 150340006664 Peptidase family M48; Region: Peptidase_M48; cl12018 150340006665 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 150340006666 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 150340006667 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 150340006668 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 150340006669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340006670 S-adenosylmethionine binding site [chemical binding]; other site 150340006671 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 150340006672 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 150340006673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 150340006674 catalytic residue [active] 150340006675 biotin synthase; Provisional; Region: PRK15108 150340006676 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 150340006677 FeS/SAM binding site; other site 150340006678 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 150340006679 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 150340006680 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 150340006681 inhibitor-cofactor binding pocket; inhibition site 150340006682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340006683 catalytic residue [active] 150340006684 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 150340006685 seryl-tRNA synthetase; Provisional; Region: PRK05431 150340006686 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 150340006687 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 150340006688 dimer interface [polypeptide binding]; other site 150340006689 active site 150340006690 motif 1; other site 150340006691 motif 2; other site 150340006692 motif 3; other site 150340006693 recombination factor protein RarA; Reviewed; Region: PRK13342 150340006694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340006695 Walker A motif; other site 150340006696 ATP binding site [chemical binding]; other site 150340006697 Walker B motif; other site 150340006698 arginine finger; other site 150340006699 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 150340006700 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 150340006701 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 150340006702 DNA translocase FtsK; Provisional; Region: PRK10263 150340006703 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340006704 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 150340006705 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 150340006706 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340006707 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 150340006708 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 150340006709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340006710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340006711 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 150340006712 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340006713 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 150340006714 substrate binding site [chemical binding]; other site 150340006715 dimerization interface [polypeptide binding]; other site 150340006716 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 150340006717 active site 150340006718 dinuclear metal binding site [ion binding]; other site 150340006719 dimerization interface [polypeptide binding]; other site 150340006720 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 150340006721 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340006722 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340006723 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 150340006724 putative catalytic site [active] 150340006725 metal binding site A [ion binding]; metal-binding site 150340006726 phosphate binding site [ion binding]; other site 150340006727 metal binding site C [ion binding]; metal-binding site 150340006728 metal binding site B [ion binding]; metal-binding site 150340006729 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 150340006730 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 150340006731 active site 150340006732 HIGH motif; other site 150340006733 dimer interface [polypeptide binding]; other site 150340006734 KMSKS motif; other site 150340006735 Membrane transport protein; Region: Mem_trans; cl09117 150340006736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340006737 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 150340006738 Protein export membrane protein; Region: SecD_SecF; cl14618 150340006739 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 150340006740 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 150340006741 dimerization interface [polypeptide binding]; other site 150340006742 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340006743 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340006744 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 150340006745 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 150340006746 Q-loop/lid; other site 150340006747 ABC transporter signature motif; other site 150340006748 Walker B; other site 150340006749 D-loop; other site 150340006750 H-loop/switch region; other site 150340006751 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 150340006752 multiple promoter invertase; Provisional; Region: mpi; PRK13413 150340006753 catalytic residues [active] 150340006754 catalytic nucleophile [active] 150340006755 Presynaptic Site I dimer interface [polypeptide binding]; other site 150340006756 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 150340006757 Synaptic Flat tetramer interface [polypeptide binding]; other site 150340006758 Synaptic Site I dimer interface [polypeptide binding]; other site 150340006759 DNA binding site [nucleotide binding] 150340006760 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 150340006761 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 150340006762 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 150340006763 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 150340006764 DNA binding site [nucleotide binding] 150340006765 Int/Topo IB signature motif; other site 150340006766 active site 150340006767 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 150340006768 Cache domain; Region: Cache_1; pfam02743 150340006769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340006770 dimer interface [polypeptide binding]; other site 150340006771 phosphorylation site [posttranslational modification] 150340006772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340006773 ATP binding site [chemical binding]; other site 150340006774 Mg2+ binding site [ion binding]; other site 150340006775 G-X-G motif; other site 150340006776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340006777 Response regulator receiver domain; Region: Response_reg; pfam00072 150340006778 active site 150340006779 phosphorylation site [posttranslational modification] 150340006780 intermolecular recognition site; other site 150340006781 dimerization interface [polypeptide binding]; other site 150340006782 Uncharacterised protein family (UPF0149); Region: UPF0149; cl01173 150340006783 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 150340006784 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 150340006785 Predicted membrane protein [Function unknown]; Region: COG3766 150340006786 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 150340006787 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 150340006788 Ion channel; Region: Ion_trans_2; cl11596 150340006789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340006790 Quinolinate synthetase A protein; Region: NadA; cl00420 150340006791 tol-pal system protein YbgF; Provisional; Region: PRK10803 150340006792 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 150340006793 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340006794 ligand binding site [chemical binding]; other site 150340006795 translocation protein TolB; Provisional; Region: tolB; PRK04792 150340006796 TolB amino-terminal domain; Region: TolB_N; pfam04052 150340006797 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 150340006798 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 150340006799 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 150340006800 TolA protein; Region: tolA_full; TIGR02794 150340006801 Gram-negative bacterial tonB protein; Region: TonB; cl10048 150340006802 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 150340006803 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 150340006804 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 150340006805 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 150340006806 active site 150340006807 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451 150340006808 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 150340006809 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 150340006810 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 150340006811 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 150340006812 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 150340006813 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 150340006814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340006815 Walker A motif; other site 150340006816 ATP binding site [chemical binding]; other site 150340006817 Walker B motif; other site 150340006818 arginine finger; other site 150340006819 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 150340006820 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 150340006821 RuvA N terminal domain; Region: RuvA_N; pfam01330 150340006822 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 150340006823 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 150340006824 active site 150340006825 putative DNA-binding cleft [nucleotide binding]; other site 150340006826 dimer interface [polypeptide binding]; other site 150340006827 Domain of unknown function DUF28; Region: DUF28; cl00361 150340006828 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 150340006829 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 150340006830 dimer interface [polypeptide binding]; other site 150340006831 anticodon binding site; other site 150340006832 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 150340006833 homodimer interface [polypeptide binding]; other site 150340006834 motif 1; other site 150340006835 active site 150340006836 motif 2; other site 150340006837 GAD domain; Region: GAD; pfam02938 150340006838 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 150340006839 active site 150340006840 motif 3; other site 150340006841 Protein of unknown function DUF72; Region: DUF72; cl00777 150340006842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340006843 S-adenosylmethionine binding site [chemical binding]; other site 150340006844 tRNA mo(5)U34 methyltransferase; Provisional; Region: PRK15068 150340006845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340006846 Protein of unknown function (DUF785); Region: DUF785; cl01682 150340006847 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 150340006848 cell division protein MukB; Provisional; Region: mukB; PRK04863 150340006849 MukB N-terminal; Region: MukB; pfam04310 150340006850 MukE-like family; Region: MukE; cl11471 150340006851 KicB killing factor; Region: KicB; cl11468 150340006852 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 150340006853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340006854 S-adenosylmethionine binding site [chemical binding]; other site 150340006855 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 150340006856 putative active site [active] 150340006857 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 150340006858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340006859 active site 150340006860 phosphorylation site [posttranslational modification] 150340006861 intermolecular recognition site; other site 150340006862 dimerization interface [polypeptide binding]; other site 150340006863 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340006864 DNA binding site [nucleotide binding] 150340006865 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 150340006866 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 150340006867 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 150340006868 DNA binding site [nucleotide binding] 150340006869 domain linker motif; other site 150340006870 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 150340006871 dimerization interface [polypeptide binding]; other site 150340006872 ligand binding site [chemical binding]; other site 150340006873 TfoX N-terminal domain; Region: TfoX_N; cl01167 150340006874 TfoX N-terminal domain; Region: TfoX_N; cl01167 150340006875 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 150340006876 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 150340006877 glycogen synthase; Provisional; Region: glgA; PRK00654 150340006878 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 150340006879 ADP-binding pocket [chemical binding]; other site 150340006880 homodimer interface [polypeptide binding]; other site 150340006881 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 150340006882 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 150340006883 ligand binding site [chemical binding]; other site 150340006884 oligomer interface [polypeptide binding]; other site 150340006885 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 150340006886 dimer interface [polypeptide binding]; other site 150340006887 N-terminal domain interface [polypeptide binding]; other site 150340006888 sulfate 1 binding site; other site 150340006889 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 150340006890 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 150340006891 active site 150340006892 interdomain interaction site; other site 150340006893 putative metal-binding site [ion binding]; other site 150340006894 nucleotide binding site [chemical binding]; other site 150340006895 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 150340006896 domain I; other site 150340006897 DNA binding groove [nucleotide binding] 150340006898 phosphate binding site [ion binding]; other site 150340006899 domain II; other site 150340006900 domain III; other site 150340006901 nucleotide binding site [chemical binding]; other site 150340006902 catalytic site [active] 150340006903 domain IV; other site 150340006904 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 150340006905 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 150340006906 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 150340006907 Protein of unknown function (DUF2498); Region: DUF2498; cl11671 150340006908 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 150340006909 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 150340006910 hinge; other site 150340006911 active site 150340006912 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 150340006913 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl01006 150340006914 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 150340006915 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 150340006916 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 150340006917 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 150340006918 rRNA binding site [nucleotide binding]; other site 150340006919 predicted 30S ribosome binding site; other site 150340006920 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 150340006921 Clp amino terminal domain; Region: Clp_N; pfam02861 150340006922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340006923 Walker A motif; other site 150340006924 ATP binding site [chemical binding]; other site 150340006925 Walker B motif; other site 150340006926 arginine finger; other site 150340006927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340006928 Walker A motif; other site 150340006929 ATP binding site [chemical binding]; other site 150340006930 Walker B motif; other site 150340006931 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 150340006932 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 150340006933 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 150340006934 DNA-binding site [nucleotide binding]; DNA binding site 150340006935 RNA-binding motif; other site 150340006936 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 150340006937 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 150340006938 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 150340006939 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 150340006940 active site 150340006941 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 150340006942 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 150340006943 trimer interface [polypeptide binding]; other site 150340006944 eyelet of channel; other site 150340006945 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 150340006946 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340006947 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340006948 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 150340006949 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 150340006950 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 150340006951 Protein of unknown function (DUF2496); Region: DUF2496; cl11670 150340006952 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 150340006953 putative phosphate binding site [ion binding]; other site 150340006954 putative catalytic site [active] 150340006955 active site 150340006956 metal binding site A [ion binding]; metal-binding site 150340006957 DNA binding site [nucleotide binding] 150340006958 putative AP binding site [nucleotide binding]; other site 150340006959 putative metal binding site B [ion binding]; other site 150340006960 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 150340006961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340006962 dimer interface [polypeptide binding]; other site 150340006963 conserved gate region; other site 150340006964 putative PBP binding loops; other site 150340006965 ABC-ATPase subunit interface; other site 150340006966 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 150340006967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340006968 dimer interface [polypeptide binding]; other site 150340006969 conserved gate region; other site 150340006970 putative PBP binding loops; other site 150340006971 ABC-ATPase subunit interface; other site 150340006972 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 150340006973 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 150340006974 substrate binding pocket [chemical binding]; other site 150340006975 membrane-bound complex binding site; other site 150340006976 hinge residues; other site 150340006977 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 150340006978 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 150340006979 Walker A/P-loop; other site 150340006980 ATP binding site [chemical binding]; other site 150340006981 Q-loop/lid; other site 150340006982 ABC transporter signature motif; other site 150340006983 Walker B; other site 150340006984 D-loop; other site 150340006985 H-loop/switch region; other site 150340006986 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 150340006987 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 150340006988 Pyruvate formate lyase 1; Region: PFL1; cd01678 150340006989 coenzyme A binding site [chemical binding]; other site 150340006990 active site 150340006991 catalytic residues [active] 150340006992 glycine loop; other site 150340006993 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 150340006994 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 150340006995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 150340006996 FeS/SAM binding site; other site 150340006997 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 150340006998 YfbU domain; Region: YfbU; cl01137 150340006999 PrkA family serine protein kinase; Provisional; Region: PRK15455 150340007000 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340007001 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 150340007002 Protein of unknown function (DUF444); Region: DUF444; pfam04285 150340007003 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 150340007004 SpoVR family protein; Provisional; Region: PRK11767 150340007005 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 150340007006 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 150340007007 Ligand binding site [chemical binding]; other site 150340007008 oligomer interface [polypeptide binding]; other site 150340007009 Trm112p-like protein; Region: Trm112p; cl01066 150340007010 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 150340007011 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 150340007012 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 150340007013 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 150340007014 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 150340007015 Walker A/P-loop; other site 150340007016 ATP binding site [chemical binding]; other site 150340007017 Q-loop/lid; other site 150340007018 ABC transporter signature motif; other site 150340007019 Walker B; other site 150340007020 D-loop; other site 150340007021 H-loop/switch region; other site 150340007022 ComEC family competence protein; Provisional; Region: PRK11539 150340007023 Competence protein; Region: Competence; cl00471 150340007024 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 150340007025 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 150340007026 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 150340007027 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 150340007028 FtsX-like permease family; Region: FtsX; pfam02687 150340007029 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 150340007030 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 150340007031 Walker A/P-loop; other site 150340007032 ATP binding site [chemical binding]; other site 150340007033 Q-loop/lid; other site 150340007034 ABC transporter signature motif; other site 150340007035 Walker B; other site 150340007036 D-loop; other site 150340007037 H-loop/switch region; other site 150340007038 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 150340007039 FtsX-like permease family; Region: FtsX; pfam02687 150340007040 transcription-repair coupling factor; Provisional; Region: PRK10689 150340007041 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 150340007042 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 150340007043 ATP binding site [chemical binding]; other site 150340007044 putative Mg++ binding site [ion binding]; other site 150340007045 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340007046 nucleotide binding region [chemical binding]; other site 150340007047 ATP-binding site [chemical binding]; other site 150340007048 TRCF domain; Region: TRCF; cl04088 150340007049 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 150340007050 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 150340007051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340007052 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 150340007053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340007054 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 150340007055 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 150340007056 Phosphotransferase enzyme family; Region: APH; pfam01636 150340007057 active site 150340007058 substrate binding site [chemical binding]; other site 150340007059 ATP binding site [chemical binding]; other site 150340007060 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 150340007061 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 150340007062 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 150340007063 putative dimer interface [polypeptide binding]; other site 150340007064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 150340007065 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 150340007066 nucleotide binding site/active site [active] 150340007067 HIT family signature motif; other site 150340007068 catalytic residue [active] 150340007069 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340007070 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340007071 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340007072 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 150340007073 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 150340007074 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 150340007075 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 150340007076 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 150340007077 metal-binding site [ion binding] 150340007078 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 150340007079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 150340007080 FOG: CBS domain [General function prediction only]; Region: COG0517 150340007081 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_16; cd04629 150340007082 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 150340007083 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 150340007084 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 150340007085 substrate binding pocket [chemical binding]; other site 150340007086 membrane-bound complex binding site; other site 150340007087 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 150340007088 substrate binding pocket [chemical binding]; other site 150340007089 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 150340007090 membrane-bound complex binding site; other site 150340007091 hinge residues; other site 150340007092 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340007093 metal binding site [ion binding]; metal-binding site 150340007094 active site 150340007095 I-site; other site 150340007096 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 150340007097 DNA binding site [nucleotide binding] 150340007098 active site 150340007099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 150340007100 acyl-CoA thioesterase II; Provisional; Region: PRK10526 150340007101 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 150340007102 active site 150340007103 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 150340007104 catalytic triad [active] 150340007105 dimer interface [polypeptide binding]; other site 150340007106 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 150340007107 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340007108 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 150340007109 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 150340007110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 150340007111 catalytic residue [active] 150340007112 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 150340007113 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 150340007114 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 150340007115 Tim44-like domain; Region: Tim44; cl09208 150340007116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 150340007117 H+ Antiporter protein; Region: 2A0121; TIGR00900 150340007118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340007119 putative substrate translocation pore; other site 150340007120 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 150340007121 putative acyl-acceptor binding pocket; other site 150340007122 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 150340007123 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 150340007124 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 150340007125 O-succinylbenzoate synthase; Provisional; Region: PRK05105 150340007126 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway...; Region: OSBS; cd03320 150340007127 active site 150340007128 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 150340007129 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 150340007130 substrate binding site [chemical binding]; other site 150340007131 oxyanion hole (OAH) forming residues; other site 150340007132 trimer interface [polypeptide binding]; other site 150340007133 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 150340007134 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 150340007135 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 150340007136 dimer interface [polypeptide binding]; other site 150340007137 tetramer interface [polypeptide binding]; other site 150340007138 PYR/PP interface [polypeptide binding]; other site 150340007139 TPP binding site [chemical binding]; other site 150340007140 TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key role in the menaquinone biosynthetic pathway, converting...; Region: TPP_SHCHC_synthase; cd02009 150340007141 TPP-binding site; other site 150340007142 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 150340007143 chorismate binding enzyme; Region: Chorismate_bind; cl10555 150340007144 tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264 150340007145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 150340007146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340007147 homodimer interface [polypeptide binding]; other site 150340007148 catalytic residue [active] 150340007149 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 150340007150 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 150340007151 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 150340007152 DTW domain; Region: DTW; cl01221 150340007153 Rhomboid family; Region: Rhomboid; cl11446 150340007154 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 150340007155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340007156 periplasmic folding chaperone; Provisional; Region: PRK10788 150340007157 SurA N-terminal domain; Region: SurA_N; pfam09312 150340007158 PPIC-type PPIASE domain; Region: Rotamase; cl08278 150340007159 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 150340007160 IHF dimer interface [polypeptide binding]; other site 150340007161 IHF - DNA interface [nucleotide binding]; other site 150340007162 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 150340007163 Found in ATP-dependent protease La (LON); Region: LON; smart00464 150340007164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340007165 Walker A motif; other site 150340007166 ATP binding site [chemical binding]; other site 150340007167 Walker B motif; other site 150340007168 arginine finger; other site 150340007169 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 150340007170 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 150340007171 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 150340007172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340007173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340007174 Walker A motif; other site 150340007175 ATP binding site [chemical binding]; other site 150340007176 Walker B motif; other site 150340007177 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 150340007178 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 150340007179 oligomer interface [polypeptide binding]; other site 150340007180 active site residues [active] 150340007181 trigger factor; Provisional; Region: tig; PRK01490 150340007182 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 150340007183 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 150340007184 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 150340007185 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 150340007186 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340007187 dimer interface [polypeptide binding]; other site 150340007188 phosphorylation site [posttranslational modification] 150340007189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340007190 ATP binding site [chemical binding]; other site 150340007191 Mg2+ binding site [ion binding]; other site 150340007192 G-X-G motif; other site 150340007193 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 150340007194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340007195 active site 150340007196 phosphorylation site [posttranslational modification] 150340007197 intermolecular recognition site; other site 150340007198 dimerization interface [polypeptide binding]; other site 150340007199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340007200 Walker A motif; other site 150340007201 ATP binding site [chemical binding]; other site 150340007202 Walker B motif; other site 150340007203 arginine finger; other site 150340007204 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340007205 DctM-like transporters; Region: DctM; pfam06808 150340007206 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340007207 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 150340007208 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 150340007209 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 150340007210 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 150340007211 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 150340007212 REJ domain; Region: REJ; pfam02010 150340007213 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 150340007214 Cation transport protein; Region: TrkH; cl10514 150340007215 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 150340007216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340007217 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340007218 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 150340007219 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 150340007220 ATP binding site [chemical binding]; other site 150340007221 Mg++ binding site [ion binding]; other site 150340007222 motif III; other site 150340007223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340007224 nucleotide binding region [chemical binding]; other site 150340007225 ATP-binding site [chemical binding]; other site 150340007226 Domain of unknown function DUF21; Region: DUF21; pfam01595 150340007227 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 150340007228 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 150340007229 Transporter associated domain; Region: CorC_HlyC; cl08393 150340007230 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 150340007231 N-acetyl-D-glucosamine binding site [chemical binding]; other site 150340007232 catalytic residue [active] 150340007233 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 150340007234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340007235 O-methyltransferase; Region: Methyltransf_2; pfam00891 150340007236 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 150340007237 putative acyl-acceptor binding pocket; other site 150340007238 Phosphopantetheine attachment site; Region: PP-binding; cl09936 150340007239 Phosphopantetheine attachment site; Region: PP-binding; cl09936 150340007240 Predicted membrane protein [Function unknown]; Region: COG4648 150340007241 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 150340007242 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 150340007243 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 150340007244 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 150340007245 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 150340007246 Ligand binding site [chemical binding]; other site 150340007247 Putative Catalytic site [active] 150340007248 DXD motif; other site 150340007249 Predicted acyltransferase [General function prediction only]; Region: COG4261 150340007250 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 150340007251 putative acyl-acceptor binding pocket; other site 150340007252 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 150340007253 active sites [active] 150340007254 tetramer interface [polypeptide binding]; other site 150340007255 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 150340007256 active site 150340007257 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 150340007258 Predicted exporter [General function prediction only]; Region: COG4258 150340007259 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 150340007260 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 150340007261 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 150340007262 dimer interface [polypeptide binding]; other site 150340007263 active site 150340007264 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 150340007265 putative active site 1 [active] 150340007266 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 150340007267 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 150340007268 NAD(P) binding site [chemical binding]; other site 150340007269 homotetramer interface [polypeptide binding]; other site 150340007270 homodimer interface [polypeptide binding]; other site 150340007271 active site 150340007272 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 150340007273 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 150340007274 dimer interface [polypeptide binding]; other site 150340007275 active site 150340007276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340007277 S-adenosylmethionine binding site [chemical binding]; other site 150340007278 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 150340007279 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 150340007280 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 150340007281 homodimer interface [polypeptide binding]; other site 150340007282 NADP binding site [chemical binding]; other site 150340007283 substrate binding site [chemical binding]; other site 150340007284 Nucleoside recognition; Region: Gate; cl00486 150340007285 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 150340007286 transcriptional activator TtdR; Provisional; Region: PRK09801 150340007287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340007288 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340007289 putative effector binding pocket; other site 150340007290 dimerization interface [polypeptide binding]; other site 150340007291 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 150340007292 lytic murein transglycosylase; Region: MltB_2; TIGR02283 150340007293 YcgL domain; Region: YcgL; cl01189 150340007294 septum formation inhibitor; Reviewed; Region: minC; PRK04804 150340007295 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 150340007296 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 150340007297 cell division inhibitor MinD; Provisional; Region: PRK10818 150340007298 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 150340007299 Switch I; other site 150340007300 Switch II; other site 150340007301 Septum formation topological specificity factor MinE; Region: MinE; cl00538 150340007302 ribonuclease D; Provisional; Region: PRK10829 150340007303 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 150340007304 putative active site [active] 150340007305 catalytic site [active] 150340007306 putative substrate binding site [chemical binding]; other site 150340007307 HRDC domain; Region: HRDC; cl02578 150340007308 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 150340007309 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 150340007310 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 150340007311 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 150340007312 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 150340007313 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 150340007314 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340007315 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 150340007316 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 150340007317 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 150340007318 putative active site [active] 150340007319 putative substrate binding site [chemical binding]; other site 150340007320 putative cosubstrate binding site; other site 150340007321 catalytic site [active] 150340007322 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cd00190 150340007323 cleavage site 150340007324 active site 150340007325 substrate binding sites [chemical binding]; other site 150340007326 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 150340007327 putative metal binding site [ion binding]; other site 150340007328 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 150340007329 arginyl-tRNA synthetase; Region: argS; TIGR00456 150340007330 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 150340007331 active site 150340007332 HIGH motif; other site 150340007333 KMSK motif region; other site 150340007334 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 150340007335 tRNA binding surface [nucleotide binding]; other site 150340007336 anticodon binding site; other site 150340007337 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 150340007338 FeoC like transcriptional regulator; Region: FeoC; cl07573 150340007339 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 150340007340 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 150340007341 G1 box; other site 150340007342 GTP/Mg2+ binding site [chemical binding]; other site 150340007343 Switch I region; other site 150340007344 G2 box; other site 150340007345 G3 box; other site 150340007346 Switch II region; other site 150340007347 G4 box; other site 150340007348 G5 box; other site 150340007349 Nucleoside recognition; Region: Gate; cl00486 150340007350 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 150340007351 Nucleoside recognition; Region: Gate; cl00486 150340007352 FeoA domain; Region: FeoA; cl00838 150340007353 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 150340007354 Helix-turn-helix domain; Region: HTH_18; pfam12833 150340007355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340007356 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 150340007357 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 150340007358 metal binding site [ion binding]; metal-binding site 150340007359 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 150340007360 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 150340007361 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 150340007362 dimer interface [polypeptide binding]; other site 150340007363 putative PBP binding regions; other site 150340007364 ABC-ATPase subunit interface; other site 150340007365 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 150340007366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340007367 CoA-ligase; Region: Ligase_CoA; pfam00549 150340007368 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 150340007369 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 150340007370 CoA-ligase; Region: Ligase_CoA; pfam00549 150340007371 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 150340007372 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 150340007373 E3 interaction surface; other site 150340007374 lipoyl attachment site [posttranslational modification]; other site 150340007375 e3 binding domain; Region: E3_binding; pfam02817 150340007376 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 150340007377 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 150340007378 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 150340007379 TPP-binding site [chemical binding]; other site 150340007380 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 150340007381 dimer interface [polypeptide binding]; other site 150340007382 PYR/PP interface [polypeptide binding]; other site 150340007383 TPP binding site [chemical binding]; other site 150340007384 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 150340007385 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 150340007386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340007387 domain; Region: Succ_DH_flav_C; pfam02910 150340007388 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 150340007389 SdhC subunit interface [polypeptide binding]; other site 150340007390 proximal heme binding site [chemical binding]; other site 150340007391 cardiolipin binding site; other site 150340007392 Iron-sulfur protein interface; other site 150340007393 proximal quinone binding site [chemical binding]; other site 150340007394 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 150340007395 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 150340007396 dimer interface [polypeptide binding]; other site 150340007397 Citrate synthase; Region: Citrate_synt; pfam00285 150340007398 active site 150340007399 citrylCoA binding site [chemical binding]; other site 150340007400 NADH binding [chemical binding]; other site 150340007401 cationic pore residues; other site 150340007402 oxalacetate/citrate binding site [chemical binding]; other site 150340007403 coenzyme A binding site [chemical binding]; other site 150340007404 catalytic triad [active] 150340007405 Uncharacterized conserved protein [Function unknown]; Region: COG0327 150340007406 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 150340007407 Domain of unknown function (DUF1853); Region: DUF1853; cl01545 150340007408 phosphoglucomutase; Validated; Region: PRK07564 150340007409 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 150340007410 active site 150340007411 substrate binding site [chemical binding]; other site 150340007412 metal binding site [ion binding]; metal-binding site 150340007413 SeqA protein; Region: SeqA; cl11470 150340007414 acyl-CoA esterase; Provisional; Region: PRK10673 150340007415 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 150340007416 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 150340007417 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 150340007418 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 150340007419 CoenzymeA binding site [chemical binding]; other site 150340007420 subunit interaction site [polypeptide binding]; other site 150340007421 PHB binding site; other site 150340007422 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 150340007423 metal binding site 2 [ion binding]; metal-binding site 150340007424 putative DNA binding helix; other site 150340007425 metal binding site 1 [ion binding]; metal-binding site 150340007426 dimer interface [polypeptide binding]; other site 150340007427 structural Zn2+ binding site [ion binding]; other site 150340007428 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 150340007429 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 150340007430 active site 150340007431 HIGH motif; other site 150340007432 nucleotide binding site [chemical binding]; other site 150340007433 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 150340007434 KMSKS motif; other site 150340007435 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 150340007436 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 150340007437 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340007438 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340007439 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 150340007440 active site turn [active] 150340007441 phosphorylation site [posttranslational modification] 150340007442 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 150340007443 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 150340007444 active site 150340007445 dimer interface [polypeptide binding]; other site 150340007446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340007447 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 150340007448 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 150340007449 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 150340007450 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 150340007451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340007452 asparagine synthetase B; Provisional; Region: asnB; PRK09431 150340007453 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 150340007454 active site 150340007455 dimer interface [polypeptide binding]; other site 150340007456 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 150340007457 Ligand Binding Site [chemical binding]; other site 150340007458 Molecular Tunnel; other site 150340007459 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 150340007460 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 150340007461 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 150340007462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340007463 putative substrate translocation pore; other site 150340007464 ferrochelatase; Reviewed; Region: hemH; PRK00035 150340007465 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 150340007466 C-terminal domain interface [polypeptide binding]; other site 150340007467 active site 150340007468 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 150340007469 active site 150340007470 N-terminal domain interface [polypeptide binding]; other site 150340007471 adenylate kinase; Reviewed; Region: adk; PRK00279 150340007472 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 150340007473 AMP-binding site [chemical binding]; other site 150340007474 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 150340007475 heat shock protein 90; Provisional; Region: PRK05218 150340007476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 150340007477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340007478 DNA binding site [nucleotide binding] 150340007479 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 150340007480 Rdx family; Region: Rdx; cl01407 150340007481 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 150340007482 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 150340007483 active site 150340007484 metal binding site [ion binding]; metal-binding site 150340007485 homotetramer interface [polypeptide binding]; other site 150340007486 FOG: CBS domain [General function prediction only]; Region: COG0517 150340007487 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_17; cd04630 150340007488 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 150340007489 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 150340007490 TIGR01777 family protein; Region: yfcH 150340007491 putative NAD(P) binding site [chemical binding]; other site 150340007492 putative active site [active] 150340007493 short chain dehydrogenase; Provisional; Region: PRK05693 150340007494 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 150340007495 NADP binding site [chemical binding]; other site 150340007496 active site 150340007497 steroid binding site; other site 150340007498 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 150340007499 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 150340007500 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 150340007501 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 150340007502 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 150340007503 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 150340007504 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 150340007505 nucleotide binding pocket [chemical binding]; other site 150340007506 K-X-D-G motif; other site 150340007507 catalytic site [active] 150340007508 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 150340007509 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 150340007510 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 150340007511 Dimer interface [polypeptide binding]; other site 150340007512 BRCT sequence motif; other site 150340007513 cell division protein ZipA; Provisional; Region: PRK04335 150340007514 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 150340007515 FtsZ protein binding site [polypeptide binding]; other site 150340007516 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 150340007517 cysteine synthases; Region: cysKM; TIGR01136 150340007518 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 150340007519 dimer interface [polypeptide binding]; other site 150340007520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340007521 catalytic residue [active] 150340007522 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 150340007523 dimerization domain swap beta strand [polypeptide binding]; other site 150340007524 regulatory protein interface [polypeptide binding]; other site 150340007525 active site 150340007526 regulatory phosphorylation site [posttranslational modification]; other site 150340007527 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 150340007528 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 150340007529 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 150340007530 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 150340007531 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cd00210 150340007532 HPr interaction site; other site 150340007533 glycerol kinase (GK) interaction site [polypeptide binding]; other site 150340007534 active site 150340007535 phosphorylation site [posttranslational modification] 150340007536 flagellin; Reviewed; Region: PRK08869 150340007537 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 150340007538 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 150340007539 flagellin; Reviewed; Region: PRK08869 150340007540 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 150340007541 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 150340007542 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 150340007543 flagellin; Reviewed; Region: PRK08869 150340007544 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 150340007545 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 150340007546 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 150340007547 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 150340007548 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08871 150340007549 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 150340007550 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 150340007551 Rod binding protein; Region: Rod-binding; cl01626 150340007552 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 150340007553 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 150340007554 Flagellar L-ring protein; Region: FlgH; cl00905 150340007555 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 150340007556 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 150340007557 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 150340007558 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 150340007559 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 150340007560 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 150340007561 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 150340007562 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 150340007563 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 150340007564 Flagellar hook capping protein; Region: FlgD; cl04347 150340007565 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 150340007566 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 150340007567 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 150340007568 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 150340007569 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 150340007570 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 150340007571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340007572 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 150340007573 Response regulator receiver domain; Region: Response_reg; pfam00072 150340007574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340007575 active site 150340007576 phosphorylation site [posttranslational modification] 150340007577 intermolecular recognition site; other site 150340007578 dimerization interface [polypeptide binding]; other site 150340007579 SAF domain; Region: SAF; cl00555 150340007580 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 150340007581 FlgN protein; Region: FlgN; cl09176 150340007582 Protein of unknown function, DUF400; Region: DUF400; cl01141 150340007583 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 150340007584 Surface antigen; Region: Surface_Ag_2; cl01155 150340007585 outer membrane protein A; Reviewed; Region: PRK10808 150340007586 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340007587 ligand binding site [chemical binding]; other site 150340007588 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 150340007589 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 150340007590 active site 150340007591 HIGH motif; other site 150340007592 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 150340007593 active site 150340007594 KMSKS motif; other site 150340007595 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 150340007596 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 150340007597 trimer interface [polypeptide binding]; other site 150340007598 eyelet of channel; other site 150340007599 copper exporting ATPase; Provisional; Region: copA; PRK10671 150340007600 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 150340007601 copper exporting ATPase; Provisional; Region: copA; PRK10671 150340007602 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 150340007603 metal-binding site [ion binding] 150340007604 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 150340007605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 150340007606 Protein of unknown function, DUF; Region: DUF411; cl01142 150340007607 Putative carbohydrate binding domain; Region: CHB_HEX; cl03918 150340007608 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 150340007609 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 150340007610 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_Sm-chitobiase-like; cd06569 150340007611 active site 150340007612 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 150340007613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 150340007614 TraB family; Region: TraB; cl12050 150340007615 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 150340007616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 150340007617 Smr domain; Region: Smr; cl02619 150340007618 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 150340007619 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 150340007620 RNA binding surface [nucleotide binding]; other site 150340007621 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 150340007622 probable active site [active] 150340007623 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 150340007624 putative deacylase active site [active] 150340007625 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 150340007626 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 150340007627 active site 150340007628 metal binding site [ion binding]; metal-binding site 150340007629 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 150340007630 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 150340007631 NeuB family; Region: NeuB; cl00496 150340007632 Uncharacterized conserved protein [Function unknown]; Region: COG2912 150340007633 hypothetical protein; Provisional; Region: PRK10941 150340007634 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 150340007635 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 150340007636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340007637 peptide chain release factor 1; Validated; Region: prfA; PRK00591 150340007638 RF-1 domain; Region: RF-1; cl02875 150340007639 RF-1 domain; Region: RF-1; cl02875 150340007640 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 150340007641 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 150340007642 tRNA; other site 150340007643 putative tRNA binding site [nucleotide binding]; other site 150340007644 putative NADP binding site [chemical binding]; other site 150340007645 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 150340007646 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 150340007647 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 150340007648 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 150340007649 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 150340007650 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 150340007651 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK04923 150340007652 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 150340007653 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 150340007654 putative active site [active] 150340007655 catalytic residue [active] 150340007656 GTP-binding protein YchF; Reviewed; Region: PRK09601 150340007657 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 150340007658 G1 box; other site 150340007659 GTP/Mg2+ binding site [chemical binding]; other site 150340007660 Switch I region; other site 150340007661 G2 box; other site 150340007662 Switch II region; other site 150340007663 G3 box; other site 150340007664 G4 box; other site 150340007665 G5 box; other site 150340007666 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 150340007667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340007668 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 150340007669 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 150340007670 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 150340007671 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 150340007672 FeS/SAM binding site; other site 150340007673 TRAM domain; Region: TRAM; cl01282 150340007674 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 150340007675 PhoH-like protein; Region: PhoH; cl12134 150340007676 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 150340007677 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 150340007678 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 150340007679 Transporter associated domain; Region: CorC_HlyC; cl08393 150340007680 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 150340007681 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 150340007682 putative active site [active] 150340007683 catalytic triad [active] 150340007684 putative dimer interface [polypeptide binding]; other site 150340007685 hypothetical protein; Provisional; Region: PRK11032 150340007686 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 150340007687 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 150340007688 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 150340007689 HIGH motif; other site 150340007690 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 150340007691 active site 150340007692 KMSKS motif; other site 150340007693 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 150340007694 tRNA binding surface [nucleotide binding]; other site 150340007695 Lipopolysaccharide-assembly; Region: LptE; cl01125 150340007696 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 150340007697 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 150340007698 Domain of unknown function DUF143; Region: DUF143; cl00519 150340007699 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 150340007700 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 150340007701 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 150340007702 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 150340007703 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 150340007704 rare lipoprotein A; Provisional; Region: PRK10672 150340007705 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 150340007706 Sporulation related domain; Region: SPOR; cl10051 150340007707 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 150340007708 Beta-lactamase; Region: Beta-lactamase; cl01009 150340007709 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 150340007710 Protein of unknown function (DUF493); Region: DUF493; cl01102 150340007711 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 150340007712 lipoyl synthase; Provisional; Region: PRK05481 150340007713 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 150340007714 FeS/SAM binding site; other site 150340007715 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 150340007716 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 150340007717 dimer interface [polypeptide binding]; other site 150340007718 glycine-pyridoxal phosphate binding site [chemical binding]; other site 150340007719 active site 150340007720 folate binding site [chemical binding]; other site 150340007721 Uncharacterized conserved protein [Function unknown]; Region: COG1284 150340007722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340007723 DNA binding site [nucleotide binding] 150340007724 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 150340007725 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 150340007726 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 150340007727 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 150340007728 active site turn [active] 150340007729 phosphorylation site [posttranslational modification] 150340007730 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340007731 trehalose repressor; Provisional; Region: treR; PRK09492 150340007732 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 150340007733 DNA binding site [nucleotide binding] 150340007734 domain linker motif; other site 150340007735 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 150340007736 dimerization interface [polypeptide binding]; other site 150340007737 ligand binding site [chemical binding]; other site 150340007738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 150340007739 active site 150340007740 motif I; other site 150340007741 motif II; other site 150340007742 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 150340007743 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 150340007744 Walker A/P-loop; other site 150340007745 ATP binding site [chemical binding]; other site 150340007746 Q-loop/lid; other site 150340007747 ABC transporter signature motif; other site 150340007748 Walker B; other site 150340007749 D-loop; other site 150340007750 H-loop/switch region; other site 150340007751 NIL domain; Region: NIL; cl09633 150340007752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340007753 dimer interface [polypeptide binding]; other site 150340007754 conserved gate region; other site 150340007755 ABC-ATPase subunit interface; other site 150340007756 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 150340007757 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; cl02380 150340007758 Syd protein; Region: Syd; cl06405 150340007759 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 150340007760 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 150340007761 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 150340007762 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340007763 metal binding site [ion binding]; metal-binding site 150340007764 active site 150340007765 I-site; other site 150340007766 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 150340007767 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 150340007768 flap endonuclease-like protein; Provisional; Region: PRK09482 150340007769 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 150340007770 active site 150340007771 metal binding site 1 [ion binding]; metal-binding site 150340007772 putative 5' ssDNA interaction site; other site 150340007773 metal binding site 3; metal-binding site 150340007774 metal binding site 2 [ion binding]; metal-binding site 150340007775 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 150340007776 putative DNA binding site [nucleotide binding]; other site 150340007777 putative metal binding site [ion binding]; other site 150340007778 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 150340007779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340007780 Protein of unknown function (DUF423); Region: DUF423; cl01008 150340007781 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 150340007782 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 150340007783 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340007784 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 150340007785 dimerization interface [polypeptide binding]; other site 150340007786 substrate binding pocket [chemical binding]; other site 150340007787 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 150340007788 THUMP domain; Region: THUMP; cl12076 150340007789 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 150340007790 Ligand Binding Site [chemical binding]; other site 150340007791 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 150340007792 active site residue [active] 150340007793 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 150340007794 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340007795 ligand binding site [chemical binding]; other site 150340007796 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 150340007797 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 150340007798 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 150340007799 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 150340007800 substrate binding pocket [chemical binding]; other site 150340007801 chain length determination region; other site 150340007802 substrate-Mg2+ binding site; other site 150340007803 catalytic residues [active] 150340007804 aspartate-rich region 1; other site 150340007805 active site lid residues [active] 150340007806 aspartate-rich region 2; other site 150340007807 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 150340007808 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 150340007809 TPP-binding site; other site 150340007810 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 150340007811 PYR/PP interface [polypeptide binding]; other site 150340007812 dimer interface [polypeptide binding]; other site 150340007813 TPP binding site [chemical binding]; other site 150340007814 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 150340007815 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 150340007816 tetramer interfaces [polypeptide binding]; other site 150340007817 binuclear metal-binding site [ion binding]; other site 150340007818 thiamine monophosphate kinase; Provisional; Region: PRK05731 150340007819 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 150340007820 ATP binding site [chemical binding]; other site 150340007821 dimerization interface [polypeptide binding]; other site 150340007822 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 150340007823 putative RNA binding site [nucleotide binding]; other site 150340007824 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 150340007825 homopentamer interface [polypeptide binding]; other site 150340007826 active site 150340007827 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 150340007828 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 150340007829 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 150340007830 dimerization interface [polypeptide binding]; other site 150340007831 active site 150340007832 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 150340007833 Lumazine binding domain; Region: Lum_binding; pfam00677 150340007834 Lumazine binding domain; Region: Lum_binding; pfam00677 150340007835 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 150340007836 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 150340007837 catalytic motif [active] 150340007838 Zn binding site [ion binding]; other site 150340007839 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 150340007840 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 150340007841 ATP cone domain; Region: ATP-cone; pfam03477 150340007842 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 150340007843 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 150340007844 putative catalytic cysteine [active] 150340007845 gamma-glutamyl kinase; Provisional; Region: PRK05429 150340007846 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 150340007847 nucleotide binding site [chemical binding]; other site 150340007848 homotetrameric interface [polypeptide binding]; other site 150340007849 putative phosphate binding site [ion binding]; other site 150340007850 putative allosteric binding site; other site 150340007851 PUA domain; Region: PUA; cl00607 150340007852 Transcriptional regulator Crl; Region: Crl; cl11653 150340007853 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 150340007854 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 150340007855 Sulfate transporter family; Region: Sulfate_transp; cl00967 150340007856 Permease family; Region: Xan_ur_permease; pfam00860 150340007857 aminoacyl-histidine dipeptidase; Region: aa-his-dipept; TIGR01893 150340007858 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 150340007859 metal binding site [ion binding]; metal-binding site 150340007860 dimer interface [polypeptide binding]; other site 150340007861 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 150340007862 Predicted deacylase [General function prediction only]; Region: COG3608 150340007863 A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the...; Region: M14_ASTE_ASPA_like_1; cd06251 150340007864 putative active site [active] 150340007865 Zn-binding site [ion binding]; other site 150340007866 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 150340007867 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 150340007868 N-terminal plug; other site 150340007869 ligand-binding site [chemical binding]; other site 150340007870 Protein of unknown function (DUF3622); Region: DUF3622; pfam12286 150340007871 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 150340007872 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 150340007873 dimerization interface [polypeptide binding]; other site 150340007874 ATP binding site [chemical binding]; other site 150340007875 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal...; Region: PurM-like; cl10019 150340007876 dimerization interface [polypeptide binding]; other site 150340007877 ATP binding site [chemical binding]; other site 150340007878 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 150340007879 putative active site [active] 150340007880 catalytic triad [active] 150340007881 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 150340007882 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 150340007883 substrate binding pocket [chemical binding]; other site 150340007884 membrane-bound complex binding site; other site 150340007885 hinge residues; other site 150340007886 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 150340007887 N-acetyl-D-glucosamine binding site [chemical binding]; other site 150340007888 catalytic residue [active] 150340007889 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 150340007890 nucleoside/Zn binding site; other site 150340007891 dimer interface [polypeptide binding]; other site 150340007892 catalytic motif [active] 150340007893 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340007894 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 150340007895 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 150340007896 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 150340007897 hypothetical protein; Provisional; Region: PRK10557 150340007898 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 150340007899 Type II transport protein GspH; Region: GspH; pfam12019 150340007900 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 150340007901 chaperone protein DnaJ; Provisional; Region: PRK10767 150340007902 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 150340007903 HSP70 interaction site [polypeptide binding]; other site 150340007904 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 150340007905 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 150340007906 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 150340007907 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 150340007908 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 150340007909 dimer interface [polypeptide binding]; other site 150340007910 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 150340007911 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 150340007912 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 150340007913 Protein of unknown function (DUF3103); Region: DUF3103; pfam11301 150340007914 recombination and repair protein; Provisional; Region: PRK10869 150340007915 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 150340007916 Walker A/P-loop; other site 150340007917 ATP binding site [chemical binding]; other site 150340007918 Q-loop/lid; other site 150340007919 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 150340007920 ABC transporter signature motif; other site 150340007921 Walker B; other site 150340007922 D-loop; other site 150340007923 H-loop/switch region; other site 150340007924 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 150340007925 Uncharacterised protein family (UPF0125); Region: UPF0125; cl01096 150340007926 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 150340007927 putative coenzyme Q binding site [chemical binding]; other site 150340007928 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 150340007929 SmpB-tmRNA interface; other site 150340007930 integrase; Provisional; Region: PRK09692 150340007931 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 150340007932 active site 150340007933 Int/Topo IB signature motif; other site 150340007934 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 150340007935 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 150340007936 putative active site [active] 150340007937 putative NTP binding site [chemical binding]; other site 150340007938 putative nucleic acid binding site [nucleotide binding]; other site 150340007939 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 150340007940 ATP binding site [chemical binding]; other site 150340007941 substrate binding site [chemical binding]; other site 150340007942 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 150340007943 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 150340007944 N-glycosylase/DNA lyase; Provisional; Region: PRK01229 150340007945 helix-hairpin-helix signature motif; other site 150340007946 multiple promoter invertase; Provisional; Region: mpi; PRK13413 150340007947 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 150340007948 catalytic residues [active] 150340007949 catalytic nucleophile [active] 150340007950 Presynaptic Site I dimer interface [polypeptide binding]; other site 150340007951 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 150340007952 Synaptic Flat tetramer interface [polypeptide binding]; other site 150340007953 Synaptic Site I dimer interface [polypeptide binding]; other site 150340007954 DNA binding site [nucleotide binding] 150340007955 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 150340007956 Int/Topo IB signature motif; other site 150340007957 active site 150340007958 DNA binding site [nucleotide binding] 150340007959 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 150340007960 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 150340007961 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 150340007962 active site flap/lid [active] 150340007963 nucleophilic elbow; other site 150340007964 catalytic triad [active] 150340007965 Surface antigen; Region: Surface_Ag_2; cl01155 150340007966 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 150340007967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340007968 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340007969 dimerization interface [polypeptide binding]; other site 150340007970 Predicted amidohydrolase [General function prediction only]; Region: COG0388 150340007971 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 150340007972 putative active site [active] 150340007973 catalytic triad [active] 150340007974 putative dimer interface [polypeptide binding]; other site 150340007975 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 150340007976 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 150340007977 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340007978 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340007979 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 150340007980 hypothetical protein; Provisional; Region: PRK07483 150340007981 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 150340007982 inhibitor-cofactor binding pocket; inhibition site 150340007983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340007984 catalytic residue [active] 150340007985 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 150340007986 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 150340007987 homodimer interface [polypeptide binding]; other site 150340007988 substrate-cofactor binding pocket; other site 150340007989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340007990 catalytic residue [active] 150340007991 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 150340007992 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 150340007993 active site 150340007994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340007995 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 150340007996 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 150340007997 dimerization interface [polypeptide binding]; other site 150340007998 substrate binding pocket [chemical binding]; other site 150340007999 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 150340008000 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 150340008001 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 150340008002 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 150340008003 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 150340008004 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but...; Region: chitinase_glyco_hydro_19; cd00325 150340008005 putative sugar binding site [chemical binding]; other site 150340008006 catalytic residues [active] 150340008007 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 150340008008 chitin/cellulose binding site [chemical binding]; other site 150340008009 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 150340008010 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340008011 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340008012 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 150340008013 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 150340008014 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 150340008015 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193 150340008016 Hexameric Replicative Helicase RepA. RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125 150340008017 Walker A motif; other site 150340008018 NTP binding site [chemical binding]; other site 150340008019 hexamer interface [polypeptide binding]; other site 150340008020 Walker B motif; other site 150340008021 integrase; Provisional; Region: PRK09692 150340008022 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 150340008023 active site 150340008024 Int/Topo IB signature motif; other site 150340008025 GMP synthase; Reviewed; Region: guaA; PRK00074 150340008026 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 150340008027 AMP/PPi binding site [chemical binding]; other site 150340008028 candidate oxyanion hole; other site 150340008029 catalytic triad [active] 150340008030 potential glutamine specificity residues [chemical binding]; other site 150340008031 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 150340008032 ATP Binding subdomain [chemical binding]; other site 150340008033 Ligand Binding sites [chemical binding]; other site 150340008034 Dimerization subdomain; other site 150340008035 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 150340008036 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 150340008037 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 150340008038 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 150340008039 active site 150340008040 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 150340008041 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 150340008042 generic binding surface II; other site 150340008043 generic binding surface I; other site 150340008044 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 150340008045 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 150340008046 GTP-binding protein Der; Reviewed; Region: PRK00093 150340008047 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 150340008048 G1 box; other site 150340008049 GTP/Mg2+ binding site [chemical binding]; other site 150340008050 Switch I region; other site 150340008051 G2 box; other site 150340008052 Switch II region; other site 150340008053 G3 box; other site 150340008054 G4 box; other site 150340008055 G5 box; other site 150340008056 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 150340008057 G1 box; other site 150340008058 GTP/Mg2+ binding site [chemical binding]; other site 150340008059 Switch I region; other site 150340008060 G2 box; other site 150340008061 G3 box; other site 150340008062 Switch II region; other site 150340008063 G4 box; other site 150340008064 G5 box; other site 150340008065 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 150340008066 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 150340008067 Trp docking motif; other site 150340008068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 150340008069 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 150340008070 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 150340008071 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 150340008072 dimer interface [polypeptide binding]; other site 150340008073 motif 1; other site 150340008074 active site 150340008075 motif 2; other site 150340008076 motif 3; other site 150340008077 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 150340008078 anticodon binding site; other site 150340008079 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 150340008080 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 150340008081 cytoskeletal protein RodZ; Provisional; Region: PRK10856 150340008082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 150340008083 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 150340008084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 150340008085 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 150340008086 active site 150340008087 multimer interface [polypeptide binding]; other site 150340008088 aminopeptidase B; Provisional; Region: PRK05015 150340008089 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 150340008090 interface (dimer of trimers) [polypeptide binding]; other site 150340008091 Substrate-binding/catalytic site; other site 150340008092 Zn-binding sites [ion binding]; other site 150340008093 Protein of unknown function (DUF528); Region: DUF528; cl01123 150340008094 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 150340008095 catalytic loop [active] 150340008096 iron binding site [ion binding]; other site 150340008097 chaperone protein HscA; Provisional; Region: hscA; PRK05183 150340008098 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 150340008099 co-chaperone HscB; Provisional; Region: hscB; PRK05014 150340008100 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 150340008101 HSP70 interaction site [polypeptide binding]; other site 150340008102 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 150340008103 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 150340008104 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 150340008105 trimerization site [polypeptide binding]; other site 150340008106 active site 150340008107 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 150340008108 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 150340008109 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 150340008110 catalytic residue [active] 150340008111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340008112 Rrf2 family protein; Region: rrf2_super; TIGR00738 150340008113 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 150340008114 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 150340008115 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 150340008116 active site 150340008117 dimerization interface [polypeptide binding]; other site 150340008118 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 150340008119 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 150340008120 Protein export membrane protein; Region: SecD_SecF; cl14618 150340008121 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 150340008122 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 150340008123 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 150340008124 Protein export membrane protein; Region: SecD_SecF; cl14618 150340008125 Preprotein translocase subunit; Region: YajC; cl00806 150340008126 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 150340008127 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 150340008128 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 150340008129 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cd00190 150340008130 active site 150340008131 substrate binding sites [chemical binding]; other site 150340008132 FOG: CBS domain [General function prediction only]; Region: COG0517 150340008133 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_15; cd04803 150340008134 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 150340008135 tetramer interface [polypeptide binding]; other site 150340008136 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 150340008137 active site 150340008138 Mg2+/Mn2+ binding site [ion binding]; other site 150340008139 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 150340008140 malate synthase A; Region: malate_syn_A; TIGR01344 150340008141 active site 150340008142 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 150340008143 dimerization interface [polypeptide binding]; other site 150340008144 peroxidase; Provisional; Region: PRK15000 150340008145 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 150340008146 dimer interface [polypeptide binding]; other site 150340008147 decamer (pentamer of dimers) interface [polypeptide binding]; other site 150340008148 catalytic triad [active] 150340008149 peroxidatic and resolving cysteines [active] 150340008150 CutC family; Region: CutC; cl01218 150340008151 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 150340008152 transcriptional regulator PhoU; Provisional; Region: PRK11115 150340008153 PhoU domain; Region: PhoU; pfam01895 150340008154 PhoU domain; Region: PhoU; pfam01895 150340008155 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 150340008156 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 150340008157 Walker A/P-loop; other site 150340008158 ATP binding site [chemical binding]; other site 150340008159 Q-loop/lid; other site 150340008160 ABC transporter signature motif; other site 150340008161 Walker B; other site 150340008162 D-loop; other site 150340008163 H-loop/switch region; other site 150340008164 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 150340008165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340008166 dimer interface [polypeptide binding]; other site 150340008167 conserved gate region; other site 150340008168 putative PBP binding loops; other site 150340008169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 150340008170 ABC-ATPase subunit interface; other site 150340008171 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 150340008172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340008173 dimer interface [polypeptide binding]; other site 150340008174 conserved gate region; other site 150340008175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340008176 ABC-ATPase subunit interface; other site 150340008177 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 150340008178 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 150340008179 domain interface [polypeptide binding]; other site 150340008180 active site 150340008181 catalytic site [active] 150340008182 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 150340008183 domain interface [polypeptide binding]; other site 150340008184 active site 150340008185 catalytic site [active] 150340008186 exopolyphosphatase; Provisional; Region: PRK10854 150340008187 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 150340008188 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340008189 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 150340008190 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 150340008191 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340008192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340008193 dimer interface [polypeptide binding]; other site 150340008194 phosphorylation site [posttranslational modification] 150340008195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340008196 ATP binding site [chemical binding]; other site 150340008197 Mg2+ binding site [ion binding]; other site 150340008198 G-X-G motif; other site 150340008199 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 150340008200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340008201 active site 150340008202 phosphorylation site [posttranslational modification] 150340008203 intermolecular recognition site; other site 150340008204 dimerization interface [polypeptide binding]; other site 150340008205 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340008206 DNA binding site [nucleotide binding] 150340008207 Putative exonuclease, RdgC; Region: RdgC; cl01122 150340008208 putative protease; Provisional; Region: PRK15452 150340008209 Peptidase family U32; Region: Peptidase_U32; cl03113 150340008210 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 150340008211 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 150340008212 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 150340008213 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 150340008214 Clp amino terminal domain; Region: Clp_N; pfam02861 150340008215 Clp amino terminal domain; Region: Clp_N; pfam02861 150340008216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340008217 Walker A motif; other site 150340008218 ATP binding site [chemical binding]; other site 150340008219 Walker B motif; other site 150340008220 arginine finger; other site 150340008221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340008222 Walker A motif; other site 150340008223 ATP binding site [chemical binding]; other site 150340008224 Walker B motif; other site 150340008225 arginine finger; other site 150340008226 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 150340008227 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 150340008228 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 150340008229 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 150340008230 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 150340008231 RNA binding surface [nucleotide binding]; other site 150340008232 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 150340008233 active site 150340008234 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 150340008235 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 150340008236 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 150340008237 substrate binding pocket [chemical binding]; other site 150340008238 membrane-bound complex binding site; other site 150340008239 hinge residues; other site 150340008240 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 150340008241 N-acetyl-D-glucosamine binding site [chemical binding]; other site 150340008242 catalytic residue [active] 150340008243 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 150340008244 30S subunit binding site; other site 150340008245 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 150340008246 Chorismate mutase type II; Region: CM_2; cl00693 150340008247 Prephenate dehydratase; Region: PDT; pfam00800 150340008248 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 150340008249 putative L-Phe binding site [chemical binding]; other site 150340008250 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 150340008251 Trp repressor protein; Region: Trp_repressor; cl01121 150340008252 lytic murein transglycosylase; Provisional; Region: PRK11619 150340008253 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 150340008254 N-acetyl-D-glucosamine binding site [chemical binding]; other site 150340008255 catalytic residue [active] 150340008256 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 150340008257 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 150340008258 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340008259 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 150340008260 ABC transporter; Region: ABC_tran_2; pfam12848 150340008261 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 150340008262 PilZ domain; Region: PilZ; cl01260 150340008263 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 150340008264 Peptidase family M23; Region: Peptidase_M23; pfam01551 150340008265 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 150340008266 Chorismate mutase type II; Region: CM_2; cl00693 150340008267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340008268 NeuB family; Region: NeuB; cl00496 150340008269 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 150340008270 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 150340008271 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 150340008272 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 150340008273 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 150340008274 putative active site [active] 150340008275 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 150340008276 Carbon starvation protein CstA; Region: CstA; cl00856 150340008277 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 150340008278 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 150340008279 GAF domain; Region: GAF; cl00853 150340008280 Histidine kinase; Region: His_kinase; pfam06580 150340008281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 150340008282 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 150340008283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340008284 active site 150340008285 phosphorylation site [posttranslational modification] 150340008286 intermolecular recognition site; other site 150340008287 dimerization interface [polypeptide binding]; other site 150340008288 LytTr DNA-binding domain; Region: LytTR; cl04498 150340008289 Low molecular weight phosphatase family; Region: LMWPc; cl00105 150340008290 LytB protein; Region: LYTB; cl00507 150340008291 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 150340008292 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 150340008293 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 150340008294 lipoprotein signal peptidase; Provisional; Region: PRK14787 150340008295 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 150340008296 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 150340008297 active site 150340008298 HIGH motif; other site 150340008299 nucleotide binding site [chemical binding]; other site 150340008300 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 150340008301 active site 150340008302 KMSKS motif; other site 150340008303 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 150340008304 tRNA binding surface [nucleotide binding]; other site 150340008305 anticodon binding site; other site 150340008306 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 150340008307 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 150340008308 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 150340008309 active site 150340008310 Riboflavin kinase; Region: Flavokinase; cl03312 150340008311 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 150340008312 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 150340008313 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 150340008314 dimerization interface [polypeptide binding]; other site 150340008315 putative DNA binding site [nucleotide binding]; other site 150340008316 putative Zn2+ binding site [ion binding]; other site 150340008317 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 150340008318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340008319 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 150340008320 putative dimerization interface [polypeptide binding]; other site 150340008321 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 150340008322 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 150340008323 conserved hypothetical protein; Region: QEGLA; TIGR02421 150340008324 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 150340008325 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 150340008326 dimerization interface [polypeptide binding]; other site 150340008327 active site 150340008328 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 150340008329 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 150340008330 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 150340008331 GAF domain; Region: GAF; cl00853 150340008332 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 150340008333 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 150340008334 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 150340008335 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where...; Region: Ap4A_hydrolase_plant_like; cd03671 150340008336 putative active site [active] 150340008337 Ap4A binding site [chemical binding]; other site 150340008338 nudix motif; other site 150340008339 putative metal binding site [ion binding]; other site 150340008340 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex; Region: MutH_Sau3AI; cd00583 150340008341 putative DNA-binding cleft [nucleotide binding]; other site 150340008342 putative DNA clevage site; other site 150340008343 molecular lever; other site 150340008344 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 150340008345 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 150340008346 active site 150340008347 catalytic tetrad [active] 150340008348 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 150340008349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340008350 Walker A motif; other site 150340008351 ATP binding site [chemical binding]; other site 150340008352 Walker B motif; other site 150340008353 arginine finger; other site 150340008354 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340008355 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 150340008356 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 150340008357 dimer interface [polypeptide binding]; other site 150340008358 putative anticodon binding site; other site 150340008359 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 150340008360 motif 1; other site 150340008361 active site 150340008362 motif 2; other site 150340008363 motif 3; other site 150340008364 RF-1 domain; Region: RF-1; cl02875 150340008365 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 150340008366 RF-1 domain; Region: RF-1; cl02875 150340008367 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 150340008368 DHH family; Region: DHH; pfam01368 150340008369 DHHA1 domain; Region: DHHA1; pfam02272 150340008370 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 150340008371 dimerization domain [polypeptide binding]; other site 150340008372 dimer interface [polypeptide binding]; other site 150340008373 catalytic residues [active] 150340008374 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 150340008375 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 150340008376 Int/Topo IB signature motif; other site 150340008377 active site 150340008378 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 150340008379 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 150340008380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340008381 S-adenosylmethionine binding site [chemical binding]; other site 150340008382 helicase 45; Provisional; Region: PTZ00424 150340008383 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 150340008384 ATP binding site [chemical binding]; other site 150340008385 Mg++ binding site [ion binding]; other site 150340008386 motif III; other site 150340008387 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340008388 nucleotide binding region [chemical binding]; other site 150340008389 ATP-binding site [chemical binding]; other site 150340008390 Protein of unknown function (DUF328); Region: DUF328; cl01143 150340008391 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 150340008392 Protein of unknown function (DUF3545); Region: DUF3545; pfam12065 150340008393 Uncharacterized conserved protein [Function unknown]; Region: COG3945 150340008394 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 150340008395 ligand binding site [chemical binding]; other site 150340008396 active site 150340008397 UGI interface [polypeptide binding]; other site 150340008398 catalytic site [active] 150340008399 endonuclease IV; Provisional; Region: PRK01060 150340008400 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 150340008401 AP (apurinic/apyrimidinic) site pocket; other site 150340008402 DNA interaction; other site 150340008403 Metal-binding active site; metal-binding site 150340008404 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 150340008405 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 150340008406 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 150340008407 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 150340008408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 150340008409 catalytic residue [active] 150340008410 homoserine kinase; Provisional; Region: PRK01212 150340008411 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 150340008412 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 150340008413 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 150340008414 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli AKI-...; Region: AAK_AK-HSDH; cd04257 150340008415 putative catalytic residues [active] 150340008416 putative nucleotide binding site [chemical binding]; other site 150340008417 putative aspartate binding site [chemical binding]; other site 150340008418 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 150340008419 dimer interface [polypeptide binding]; other site 150340008420 putative threonine allosteric regulatory site; other site 150340008421 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 150340008422 putative threonine allosteric regulatory site; other site 150340008423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340008424 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 150340008425 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 150340008426 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 150340008427 two-component response regulator; Provisional; Region: PRK11173 150340008428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340008429 active site 150340008430 phosphorylation site [posttranslational modification] 150340008431 intermolecular recognition site; other site 150340008432 dimerization interface [polypeptide binding]; other site 150340008433 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340008434 DNA binding site [nucleotide binding] 150340008435 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 150340008436 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 150340008437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 150340008438 putative active site [active] 150340008439 heme pocket [chemical binding]; other site 150340008440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340008441 dimer interface [polypeptide binding]; other site 150340008442 phosphorylation site [posttranslational modification] 150340008443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340008444 ATP binding site [chemical binding]; other site 150340008445 Mg2+ binding site [ion binding]; other site 150340008446 G-X-G motif; other site 150340008447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340008448 active site 150340008449 phosphorylation site [posttranslational modification] 150340008450 intermolecular recognition site; other site 150340008451 dimerization interface [polypeptide binding]; other site 150340008452 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 150340008453 putative binding surface; other site 150340008454 active site 150340008455 PAS domain S-box; Region: sensory_box; TIGR00229 150340008456 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 150340008457 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340008458 metal binding site [ion binding]; metal-binding site 150340008459 active site 150340008460 I-site; other site 150340008461 radical SAM protein, TIGR01212 family; Region: TIGR01212 150340008462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 150340008463 FeS/SAM binding site; other site 150340008464 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 150340008465 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 150340008466 active site 150340008467 dimer interface [polypeptide binding]; other site 150340008468 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 150340008469 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 150340008470 active site 150340008471 FMN binding site [chemical binding]; other site 150340008472 substrate binding site [chemical binding]; other site 150340008473 3Fe-4S cluster binding site [ion binding]; other site 150340008474 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 150340008475 domain interface; other site 150340008476 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 150340008477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340008478 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 150340008479 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 150340008480 active site 150340008481 dimer interface [polypeptide binding]; other site 150340008482 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 150340008483 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 150340008484 active site 150340008485 FMN binding site [chemical binding]; other site 150340008486 substrate binding site [chemical binding]; other site 150340008487 3Fe-4S cluster binding site [ion binding]; other site 150340008488 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 150340008489 domain interface; other site 150340008490 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 150340008491 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 150340008492 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 150340008493 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 150340008494 5'-methylthioadenosine nucleosidase; Region: PLN02584 150340008495 CobD/Cbib protein; Region: CobD_Cbib; cl00561 150340008496 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 150340008497 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal...; Region: BtuF; cd01144 150340008498 cobalamin binding residues [chemical binding]; other site 150340008499 putative BtuC binding residues; other site 150340008500 dimer interface [polypeptide binding]; other site 150340008501 hypothetical protein; Provisional; Region: PRK10578 150340008502 UPF0126 domain; Region: UPF0126; pfam03458 150340008503 UPF0126 domain; Region: UPF0126; pfam03458 150340008504 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 150340008505 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 150340008506 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 150340008507 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 150340008508 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 150340008509 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 150340008510 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 150340008511 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 150340008512 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 150340008513 IMP binding site; other site 150340008514 dimer interface [polypeptide binding]; other site 150340008515 interdomain contacts; other site 150340008516 partial ornithine binding site; other site 150340008517 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 150340008518 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 150340008519 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 150340008520 catalytic site [active] 150340008521 subunit interface [polypeptide binding]; other site 150340008522 dihydrodipicolinate reductase; Provisional; Region: PRK00048 150340008523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340008524 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 150340008525 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 150340008526 active site 150340008527 8-oxo-dGMP binding site [chemical binding]; other site 150340008528 nudix motif; other site 150340008529 metal binding site [ion binding]; metal-binding site 150340008530 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 150340008531 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340008532 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 150340008533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340008534 nucleotide binding region [chemical binding]; other site 150340008535 ATP-binding site [chemical binding]; other site 150340008536 SEC-C motif; Region: SEC-C; cl12132 150340008537 Protein of unknown function (DUF721); Region: DUF721; cl02324 150340008538 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 150340008539 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 150340008540 cell division protein FtsZ; Validated; Region: PRK09330 150340008541 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 150340008542 nucleotide binding site [chemical binding]; other site 150340008543 SulA interaction site; other site 150340008544 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 150340008545 Cell division protein FtsA; Region: FtsA; cl11496 150340008546 Cell division protein FtsA; Region: FtsA; cl11496 150340008547 cell division protein FtsQ; Provisional; Region: PRK10775 150340008548 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 150340008549 Cell division protein FtsQ; Region: FtsQ; pfam03799 150340008550 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 150340008551 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 150340008552 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 150340008553 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 150340008554 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 150340008555 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 150340008556 active site 150340008557 homodimer interface [polypeptide binding]; other site 150340008558 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 150340008559 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04663 150340008560 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 150340008561 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 150340008562 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 150340008563 Mg++ binding site [ion binding]; other site 150340008564 putative catalytic motif [active] 150340008565 putative substrate binding site [chemical binding]; other site 150340008566 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 150340008567 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 150340008568 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 150340008569 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 150340008570 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 150340008571 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 150340008572 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 150340008573 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 150340008574 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 150340008575 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 150340008576 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 150340008577 Septum formation initiator; Region: DivIC; cl11433 150340008578 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 150340008579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340008580 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 150340008581 Predicted methyltransferases [General function prediction only]; Region: COG0313 150340008582 LppC putative lipoprotein; Region: LppC; pfam04348 150340008583 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 150340008584 putative ligand binding site [chemical binding]; other site 150340008585 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 150340008586 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 150340008587 dimer interface [polypeptide binding]; other site 150340008588 active site 150340008589 outer membrane lipoprotein; Provisional; Region: PRK11023 150340008590 BON domain; Region: BON; cl02771 150340008591 BON domain; Region: BON; cl02771 150340008592 Stringent starvation protein B; Region: SspB; cl01120 150340008593 stringent starvation protein A; Provisional; Region: sspA; PRK09481 150340008594 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 150340008595 C-terminal domain interface [polypeptide binding]; other site 150340008596 putative GSH binding site (G-site) [chemical binding]; other site 150340008597 dimer interface [polypeptide binding]; other site 150340008598 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 150340008599 dimer interface [polypeptide binding]; other site 150340008600 N-terminal domain interface [polypeptide binding]; other site 150340008601 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 150340008602 cytochrome b; Provisional; Region: CYTB; MTH00145 150340008603 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cd00284 150340008604 Qi binding site; other site 150340008605 intrachain domain interface; other site 150340008606 interchain domain interface [polypeptide binding]; other site 150340008607 heme bH binding site [chemical binding]; other site 150340008608 heme bL binding site [chemical binding]; other site 150340008609 Qo binding site; other site 150340008610 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: cytochrome_b_C; cd00290 150340008611 interchain domain interface [polypeptide binding]; other site 150340008612 intrachain domain interface; other site 150340008613 Qi binding site; other site 150340008614 Qo binding site; other site 150340008615 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 150340008616 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 150340008617 [2Fe-2S] cluster binding site [ion binding]; other site 150340008618 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 150340008619 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 150340008620 23S rRNA interface [nucleotide binding]; other site 150340008621 L3 interface [polypeptide binding]; other site 150340008622 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 150340008623 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 150340008624 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 150340008625 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 150340008626 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 150340008627 protein binding site [polypeptide binding]; other site 150340008628 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 150340008629 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 150340008630 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 150340008631 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 150340008632 protein binding site [polypeptide binding]; other site 150340008633 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 150340008634 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 150340008635 CAP-like domain; other site 150340008636 Active site [active] 150340008637 primary dimer interface [polypeptide binding]; other site 150340008638 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 150340008639 TopoisomeraseII; Region: TOP2c; smart00433 150340008640 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 150340008641 anchoring element; other site 150340008642 dimer interface [polypeptide binding]; other site 150340008643 ATP binding site [chemical binding]; other site 150340008644 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 150340008645 active site 150340008646 metal binding site [ion binding]; metal-binding site 150340008647 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 150340008648 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 150340008649 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 150340008650 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 150340008651 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 150340008652 active site 150340008653 metal binding site [ion binding]; metal-binding site 150340008654 hexamer interface [polypeptide binding]; other site 150340008655 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 150340008656 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 150340008657 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 150340008658 dimer interface [polypeptide binding]; other site 150340008659 ADP-ribose binding site [chemical binding]; other site 150340008660 active site 150340008661 nudix motif; other site 150340008662 metal binding site [ion binding]; metal-binding site 150340008663 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 150340008664 Outer membrane efflux protein; Region: OEP; pfam02321 150340008665 Outer membrane efflux protein; Region: OEP; pfam02321 150340008666 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 150340008667 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 150340008668 putative ribose interaction site [chemical binding]; other site 150340008669 putative ADP binding site [chemical binding]; other site 150340008670 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 150340008671 active site 150340008672 nucleotide binding site [chemical binding]; other site 150340008673 HIGH motif; other site 150340008674 KMSKS motif; other site 150340008675 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 150340008676 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 150340008677 metal binding triad; other site 150340008678 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 150340008679 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 150340008680 metal binding triad; other site 150340008681 capsid maturational protease; Provisional; Region: PHA03369 150340008682 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340008683 Ion transport protein; Region: Ion_trans; pfam00520 150340008684 Ion channel; Region: Ion_trans_2; cl11596 150340008685 Uncharacterized conserved protein [Function unknown]; Region: COG3025 150340008686 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 150340008687 putative active site [active] 150340008688 putative metal binding residues [ion binding]; other site 150340008689 signature motif; other site 150340008690 putative triphosphate binding site [ion binding]; other site 150340008691 CHAD domain; Region: CHAD; cl10506 150340008692 TIGR00153 family protein; Region: TIGR00153 150340008693 Phosphate transporter family; Region: PHO4; cl00396 150340008694 Phosphate transporter family; Region: PHO4; cl00396 150340008695 nitrite reductase subunit NirD; Provisional; Region: PRK14989 150340008696 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 150340008697 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 150340008698 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain...; Region: Rieske_NirD; cd03529 150340008699 Domain of unknown function (DUF296); Region: DUF296; cl00720 150340008700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 150340008701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 150340008702 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 150340008703 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 150340008704 putative C-terminal domain interface [polypeptide binding]; other site 150340008705 putative GSH binding site (G-site) [chemical binding]; other site 150340008706 putative dimer interface [polypeptide binding]; other site 150340008707 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 150340008708 putative N-terminal domain interface [polypeptide binding]; other site 150340008709 putative dimer interface [polypeptide binding]; other site 150340008710 putative substrate binding pocket (H-site) [chemical binding]; other site 150340008711 Response regulator receiver domain; Region: Response_reg; pfam00072 150340008712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340008713 active site 150340008714 phosphorylation site [posttranslational modification] 150340008715 intermolecular recognition site; other site 150340008716 dimerization interface [polypeptide binding]; other site 150340008717 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 150340008718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 150340008719 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 150340008720 Catalytic domain of Protein Kinases; Region: PKc; cd00180 150340008721 active site 150340008722 ATP binding site [chemical binding]; other site 150340008723 substrate binding site [chemical binding]; other site 150340008724 activation loop (A-loop); other site 150340008725 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 150340008726 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 150340008727 phosphopeptide binding site; other site 150340008728 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 150340008729 Bacterial protein of unknown function (DUF876); Region: DUF876; cl01406 150340008730 hypothetical protein; Provisional; Region: PRK07033 150340008731 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 150340008732 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340008733 ligand binding site [chemical binding]; other site 150340008734 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 150340008735 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 150340008736 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 150340008737 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 150340008738 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 150340008739 Active site [active] 150340008740 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 150340008741 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 150340008742 Protein of unknown function (DUF770); Region: DUF770; cl01402 150340008743 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 150340008744 Protein of unknown function (DUF877); Region: DUF877; pfam05943 150340008745 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 150340008746 Protein of unknown function (DUF877); Region: DUF877; pfam05943 150340008747 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 150340008748 ImpE protein; Region: ImpE; pfam07024 150340008749 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 150340008750 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 150340008751 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 150340008752 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 150340008753 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 150340008754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340008755 Walker A motif; other site 150340008756 ATP binding site [chemical binding]; other site 150340008757 Walker B motif; other site 150340008758 arginine finger; other site 150340008759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340008760 Walker A motif; other site 150340008761 ATP binding site [chemical binding]; other site 150340008762 Walker B motif; other site 150340008763 arginine finger; other site 150340008764 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 150340008765 Protein of unknown function (DUF796); Region: DUF796; cl01226 150340008766 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 150340008767 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 150340008768 Uncharacterized conserved protein [Function unknown]; Region: COG4104 150340008769 PAAR motif; Region: PAAR_motif; pfam05488 150340008770 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 150340008771 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 150340008772 active site 150340008773 metal binding site [ion binding]; metal-binding site 150340008774 DNA binding site [nucleotide binding] 150340008775 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 150340008776 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 150340008777 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 150340008778 Walker A/P-loop; other site 150340008779 ATP binding site [chemical binding]; other site 150340008780 Q-loop/lid; other site 150340008781 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 150340008782 ABC transporter signature motif; other site 150340008783 Walker B; other site 150340008784 D-loop; other site 150340008785 H-loop/switch region; other site 150340008786 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 150340008787 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340008788 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 150340008789 putative dimerization interface [polypeptide binding]; other site 150340008790 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 150340008791 DctM-like transporters; Region: DctM; pfam06808 150340008792 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340008793 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 150340008794 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 150340008795 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 150340008796 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 150340008797 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 150340008798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340008799 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 150340008800 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 150340008801 homotrimer interaction site [polypeptide binding]; other site 150340008802 putative active site [active] 150340008803 Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; Region: CY; cl09238 150340008804 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 150340008805 A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the...; Region: M14_ASTE_ASPA_like_1; cd06251 150340008806 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 150340008807 putative active site [active] 150340008808 Zn-binding site [ion binding]; other site 150340008809 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340008810 Predicted membrane protein [Function unknown]; Region: COG1288 150340008811 Cytochrome c; Region: Cytochrom_C; cl11414 150340008812 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 150340008813 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 150340008814 tetramer interface [polypeptide binding]; other site 150340008815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340008816 catalytic residue [active] 150340008817 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 150340008818 dimer interface [polypeptide binding]; other site 150340008819 ADP-ribose binding site [chemical binding]; other site 150340008820 active site 150340008821 nudix motif; other site 150340008822 metal binding site [ion binding]; metal-binding site 150340008823 regulatory ATPase RavA; Provisional; Region: PRK13531 150340008824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340008825 Walker A motif; other site 150340008826 ATP binding site [chemical binding]; other site 150340008827 Walker B motif; other site 150340008828 arginine finger; other site 150340008829 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 150340008830 hypothetical protein; Provisional; Region: yieM; PRK10997 150340008831 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: VWA_YIEM_type; cd01462 150340008832 metal ion-dependent adhesion site (MIDAS); other site 150340008833 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340008834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340008835 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340008836 putative effector binding pocket; other site 150340008837 dimerization interface [polypeptide binding]; other site 150340008838 D-lactate dehydrogenase; Provisional; Region: PRK11183 150340008839 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 150340008840 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 150340008841 AzlC protein; Region: AzlC; cl00570 150340008842 alanine racemase; Reviewed; Region: PRK13340 150340008843 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; Region: PLPDE_III_AR2; cd06826 150340008844 active site 150340008845 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 150340008846 dimer interface [polypeptide binding]; other site 150340008847 substrate binding site [chemical binding]; other site 150340008848 catalytic residues [active] 150340008849 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 150340008850 Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565 150340008851 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340008852 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340008853 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340008854 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 150340008855 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 150340008856 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 150340008857 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 150340008858 active site flap/lid [active] 150340008859 nucleophilic elbow; other site 150340008860 catalytic triad [active] 150340008861 CHAD domain; Region: CHAD; cl10506 150340008862 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 150340008863 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 150340008864 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 150340008865 PAS fold; Region: PAS_3; pfam08447 150340008866 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 150340008867 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340008868 metal binding site [ion binding]; metal-binding site 150340008869 active site 150340008870 I-site; other site 150340008871 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 150340008872 C-term; Region: GreA_GreB; pfam01272 150340008873 nitrite reductase subunit NirD; Provisional; Region: PRK14989 150340008874 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 150340008875 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 150340008876 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 150340008877 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain...; Region: Rieske_NirD; cd03529 150340008878 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 150340008879 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 150340008880 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 150340008881 putative metal binding site [ion binding]; other site 150340008882 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 150340008883 siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950 150340008884 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 150340008885 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 150340008886 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 150340008887 N-terminal plug; other site 150340008888 ligand-binding site [chemical binding]; other site 150340008889 Protein of unknown function (DUF2986); Region: DUF2986; pfam11661 150340008890 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 150340008891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340008892 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 150340008893 putative MFS family transporter protein; Provisional; Region: PRK03633 150340008894 thioredoxin 2; Provisional; Region: PRK10996 150340008895 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 150340008896 catalytic residues [active] 150340008897 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 150340008898 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 150340008899 dimer interface [polypeptide binding]; other site 150340008900 active site 150340008901 CoA binding pocket [chemical binding]; other site 150340008902 Protein of unknown function (DUF1501); Region: DUF1501; cl01699 150340008903 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 150340008904 Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643 150340008905 tetramerization interface [polypeptide binding]; other site 150340008906 substrate binding pocket [chemical binding]; other site 150340008907 catalytic residues [active] 150340008908 inhibitor binding sites; inhibition site 150340008909 NADP(H) binding site [chemical binding]; other site 150340008910 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 150340008911 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 150340008912 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 150340008913 regulatory protein UhpC; Provisional; Region: PRK11663 150340008914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340008915 putative substrate translocation pore; other site 150340008916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340008917 sensory histidine kinase UhpB; Provisional; Region: PRK11644 150340008918 MASE1; Region: MASE1; pfam05231 150340008919 Histidine kinase; Region: HisKA_3; pfam07730 150340008920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 150340008921 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 150340008922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340008923 active site 150340008924 phosphorylation site [posttranslational modification] 150340008925 intermolecular recognition site; other site 150340008926 dimerization interface [polypeptide binding]; other site 150340008927 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 150340008928 DNA binding residues [nucleotide binding] 150340008929 dimerization interface [polypeptide binding]; other site 150340008930 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 150340008931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340008932 putative substrate translocation pore; other site 150340008933 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 150340008934 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340008935 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340008936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 150340008937 dimerization interface [polypeptide binding]; other site 150340008938 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 150340008939 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 150340008940 putative molybdopterin cofactor binding site [chemical binding]; other site 150340008941 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787 150340008942 putative molybdopterin cofactor binding site; other site 150340008943 Electron transfer DM13; Region: DM13; cl02735 150340008944 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 150340008945 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 150340008946 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 150340008947 aspartate racemase; Region: asp_race; TIGR00035 150340008948 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 150340008949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340008950 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 150340008951 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar rhodanese-...; Region: RHOD_Pyr_redox; cd01524 150340008952 active site residue [active] 150340008953 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 150340008954 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 150340008955 dimerization interface [polypeptide binding]; other site 150340008956 putative DNA binding site [nucleotide binding]; other site 150340008957 putative Zn2+ binding site [ion binding]; other site 150340008958 YeeE/YedE family (DUF395); Region: DUF395; cl01018 150340008959 YeeE/YedE family (DUF395); Region: DUF395; cl01018 150340008960 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 150340008961 Protein export membrane protein; Region: SecD_SecF; cl14618 150340008962 Protein export membrane protein; Region: SecD_SecF; cl14618 150340008963 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 150340008964 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 150340008965 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 150340008966 putative catalytic site [active] 150340008967 putative metal binding site [ion binding]; other site 150340008968 putative phosphate binding site [ion binding]; other site 150340008969 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 150340008970 ATP cone domain; Region: ATP-cone; pfam03477 150340008971 Class III ribonucleotide reductase; Region: RNR_III; cd01675 150340008972 effector binding site; other site 150340008973 active site 150340008974 Zn binding site [ion binding]; other site 150340008975 glycine loop; other site 150340008976 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 150340008977 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 150340008978 FeS/SAM binding site; other site 150340008979 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 150340008980 MatE; Region: MatE; cl10513 150340008981 MatE; Region: MatE; cl10513 150340008982 Cupin domain; Region: Cupin_2; cl09118 150340008983 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340008984 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340008985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340008986 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 150340008987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340008988 homodimer interface [polypeptide binding]; other site 150340008989 catalytic residue [active] 150340008990 Protein of unknown function (DUF785); Region: DUF785; cl01682 150340008991 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 150340008992 cobyric acid synthase; Provisional; Region: PRK00784 150340008993 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 150340008994 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 150340008995 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 150340008996 catalytic triad [active] 150340008997 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340008998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340008999 dimer interface [polypeptide binding]; other site 150340009000 conserved gate region; other site 150340009001 putative PBP binding loops; other site 150340009002 ABC-ATPase subunit interface; other site 150340009003 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 150340009004 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340009005 Walker A/P-loop; other site 150340009006 ATP binding site [chemical binding]; other site 150340009007 Q-loop/lid; other site 150340009008 ABC transporter signature motif; other site 150340009009 Walker B; other site 150340009010 D-loop; other site 150340009011 H-loop/switch region; other site 150340009012 TOBE domain; Region: TOBE_2; cl01440 150340009013 Protein of unknown function (DUF3069); Region: DUF3069; pfam11269 150340009014 Response regulator receiver domain; Region: Response_reg; pfam00072 150340009015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340009016 active site 150340009017 phosphorylation site [posttranslational modification] 150340009018 intermolecular recognition site; other site 150340009019 dimerization interface [polypeptide binding]; other site 150340009020 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340009021 metal binding site [ion binding]; metal-binding site 150340009022 active site 150340009023 I-site; other site 150340009024 Protein of unknown function (DUF3233); Region: DUF3233; pfam11557 150340009025 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340009026 metal binding site [ion binding]; metal-binding site 150340009027 active site 150340009028 I-site; other site 150340009029 Late competence development protein ComFB; Region: ComFB; pfam10719 150340009030 Transcriptional activator HlyU; Region: HlyU; cl02273 150340009031 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 150340009032 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 150340009033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340009034 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 150340009035 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 150340009036 Domain of unknown function (DUF3404); Region: DUF3404; pfam11884 150340009037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 150340009038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 150340009039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340009040 ATP binding site [chemical binding]; other site 150340009041 Mg2+ binding site [ion binding]; other site 150340009042 G-X-G motif; other site 150340009043 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 150340009044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340009045 active site 150340009046 phosphorylation site [posttranslational modification] 150340009047 intermolecular recognition site; other site 150340009048 dimerization interface [polypeptide binding]; other site 150340009049 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340009050 DNA binding site [nucleotide binding] 150340009051 Protein of unknown function (DUF2861); Region: DUF2861; pfam11060 150340009052 Uncharacterised protein family (UPF0181); Region: UPF0181; cl11477 150340009053 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 150340009054 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340009055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340009056 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340009057 dimerization interface [polypeptide binding]; other site 150340009058 putative transcription regulator; Region: PHA01082 150340009059 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 150340009060 putative homodimer interface [polypeptide binding]; other site 150340009061 putative active site [active] 150340009062 catalytic site [active] 150340009063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340009064 putative assembly protein; Region: PHA00350 150340009065 Zonular occludens toxin (Zot); Region: Zot; cl01706 150340009066 hypothetical protein; Region: PHA01159 150340009067 Protein of unknown function (DUF1293); Region: DUF1293; cl11645 150340009068 DNA replication initiation protein; Region: PHA00202 150340009069 Replication initiation factor; Region: Rep_trans; pfam02486 150340009070 hypothetical protein; Region: PHA01083 150340009071 Phage related protein; Region: DUF3693; pfam12472 150340009072 translation initiation factor Sui1; Validated; Region: PRK06824 150340009073 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cl00229 150340009074 Predicted RNA interaction site [nucleotide binding]; other site 150340009075 putative binding site; other site 150340009076 Mutations affecting start-site selection; other site 150340009077 Protein of unknown function (DUF3319); Region: DUF3319; pfam11782 150340009078 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 150340009079 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 150340009080 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 150340009081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 150340009082 Sporulation related domain; Region: SPOR; cl10051 150340009083 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 150340009084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340009085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340009086 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340009087 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 150340009088 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340009089 dimerization interface [polypeptide binding]; other site 150340009090 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 150340009091 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 150340009092 N-terminal plug; other site 150340009093 ligand-binding site [chemical binding]; other site 150340009094 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 150340009095 UDP-glucose 4-epimerase; Region: PLN02240 150340009096 NAD binding site [chemical binding]; other site 150340009097 homodimer interface [polypeptide binding]; other site 150340009098 active site 150340009099 substrate binding site [chemical binding]; other site 150340009100 sensory histidine kinase AtoS; Provisional; Region: PRK11360 150340009101 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 150340009102 dimerization interface [polypeptide binding]; other site 150340009103 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340009104 PAS domain S-box; Region: sensory_box; TIGR00229 150340009105 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 150340009106 putative active site [active] 150340009107 heme pocket [chemical binding]; other site 150340009108 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340009109 metal binding site [ion binding]; metal-binding site 150340009110 active site 150340009111 I-site; other site 150340009112 LamB/YcsF family; Region: LamB_YcsF; cl00664 150340009113 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 150340009114 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 150340009115 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 150340009116 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 150340009117 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 150340009118 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 150340009119 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 150340009120 Walker A/P-loop; other site 150340009121 ATP binding site [chemical binding]; other site 150340009122 Q-loop/lid; other site 150340009123 ABC transporter signature motif; other site 150340009124 Walker B; other site 150340009125 D-loop; other site 150340009126 H-loop/switch region; other site 150340009127 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 150340009128 active site 150340009129 catalytic triad [active] 150340009130 oxyanion hole [active] 150340009131 switch loop; other site 150340009132 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 150340009133 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 150340009134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340009135 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 150340009136 GAF domain; Region: GAF; cl00853 150340009137 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340009138 metal binding site [ion binding]; metal-binding site 150340009139 active site 150340009140 I-site; other site 150340009141 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340009142 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 150340009143 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340009144 Walker A/P-loop; other site 150340009145 ATP binding site [chemical binding]; other site 150340009146 Q-loop/lid; other site 150340009147 ABC transporter signature motif; other site 150340009148 Walker B; other site 150340009149 D-loop; other site 150340009150 H-loop/switch region; other site 150340009151 DNA-J related protein; Region: DNAJ_related; pfam12339 150340009152 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 150340009153 HSP70 interaction site [polypeptide binding]; other site 150340009154 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 150340009155 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 150340009156 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 150340009157 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 150340009158 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 150340009159 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 150340009160 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 150340009161 Protein of unknown function (DUF3389); Region: DUF3389; pfam11869 150340009162 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 150340009163 CoenzymeA binding site [chemical binding]; other site 150340009164 subunit interaction site [polypeptide binding]; other site 150340009165 PHB binding site; other site 150340009166 Peptidase family M48; Region: Peptidase_M48; cl12018 150340009167 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 150340009168 active site 150340009169 putative substrate binding region [chemical binding]; other site 150340009170 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 150340009171 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 150340009172 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 150340009173 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 150340009174 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 150340009175 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 150340009176 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 150340009177 PhnA protein; Region: PhnA; pfam03831 150340009178 Integral membrane protein TerC family; Region: TerC; cl10468 150340009179 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 150340009180 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 150340009181 active site 150340009182 metal binding site [ion binding]; metal-binding site 150340009183 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 150340009184 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 150340009185 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 150340009186 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 150340009187 putative active site [active] 150340009188 putative metal-binding site [ion binding]; other site 150340009189 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 150340009190 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 150340009191 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340009192 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 150340009193 putative dimerization interface [polypeptide binding]; other site 150340009194 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 150340009195 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 150340009196 YceI-like domain; Region: YceI; cl01001 150340009197 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 150340009198 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 150340009199 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340009200 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 150340009201 DEAD-like helicases superfamily; Region: DEXDc; smart00487 150340009202 ATP binding site [chemical binding]; other site 150340009203 Mg++ binding site [ion binding]; other site 150340009204 motif III; other site 150340009205 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340009206 nucleotide binding region [chemical binding]; other site 150340009207 ATP-binding site [chemical binding]; other site 150340009208 Protein of unknown function, DUF479; Region: DUF479; cl01203 150340009209 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340009210 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340009211 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340009212 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 150340009213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 150340009214 motif II; other site 150340009215 CreA protein; Region: CreA; cl01154 150340009216 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 150340009217 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 150340009218 substrate binding site [chemical binding]; other site 150340009219 ATP binding site [chemical binding]; other site 150340009220 formate--tetrahydrofolate ligase; Provisional; Region: PRK13506 150340009221 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 150340009222 Potassium binding sites [ion binding]; other site 150340009223 Cesium cation binding sites [ion binding]; other site 150340009224 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 150340009225 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 150340009226 ligand binding site [chemical binding]; other site 150340009227 oligomer interface [polypeptide binding]; other site 150340009228 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 150340009229 dimer interface [polypeptide binding]; other site 150340009230 N-terminal domain interface [polypeptide binding]; other site 150340009231 sulfate 1 binding site; other site 150340009232 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 150340009233 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 150340009234 chitin/cellulose binding site [chemical binding]; other site 150340009235 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 150340009236 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548 150340009237 active site 150340009238 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 150340009239 Chitinase C; Region: ChiC; pfam06483 150340009240 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 150340009241 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 150340009242 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340009243 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340009244 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 150340009245 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 150340009246 dimer interface [polypeptide binding]; other site 150340009247 active site 150340009248 metal binding site [ion binding]; metal-binding site 150340009249 YhhN-like protein; Region: YhhN; cl01505 150340009250 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 150340009251 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 150340009252 Walker A/P-loop; other site 150340009253 ATP binding site [chemical binding]; other site 150340009254 Q-loop/lid; other site 150340009255 ABC transporter signature motif; other site 150340009256 Walker B; other site 150340009257 D-loop; other site 150340009258 H-loop/switch region; other site 150340009259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340009260 dimer interface [polypeptide binding]; other site 150340009261 conserved gate region; other site 150340009262 putative PBP binding loops; other site 150340009263 ABC-ATPase subunit interface; other site 150340009264 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 150340009265 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 150340009266 substrate binding pocket [chemical binding]; other site 150340009267 membrane-bound complex binding site; other site 150340009268 hinge residues; other site 150340009269 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 150340009270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340009271 dimer interface [polypeptide binding]; other site 150340009272 conserved gate region; other site 150340009273 putative PBP binding loops; other site 150340009274 ABC-ATPase subunit interface; other site 150340009275 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340009276 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 150340009277 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 150340009278 putative catalytic site [active] 150340009279 putative metal binding site [ion binding]; other site 150340009280 putative phosphate binding site [ion binding]; other site 150340009281 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 150340009282 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 150340009283 DNA binding site [nucleotide binding] 150340009284 domain linker motif; other site 150340009285 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 150340009286 dimerization interface [polypeptide binding]; other site 150340009287 ligand binding site [chemical binding]; other site 150340009288 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 150340009289 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 150340009290 active site 150340009291 phosphorylation site [posttranslational modification] 150340009292 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 150340009293 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 150340009294 dimerization domain swap beta strand [polypeptide binding]; other site 150340009295 regulatory protein interface [polypeptide binding]; other site 150340009296 active site 150340009297 regulatory phosphorylation site [posttranslational modification]; other site 150340009298 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 150340009299 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 150340009300 putative substrate binding site [chemical binding]; other site 150340009301 putative ATP binding site [chemical binding]; other site 150340009302 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 150340009303 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 150340009304 P-loop; other site 150340009305 active site 150340009306 phosphorylation site [posttranslational modification] 150340009307 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 150340009308 P-loop; other site 150340009309 active site 150340009310 phosphorylation site [posttranslational modification] 150340009311 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340009312 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 150340009313 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 150340009314 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 150340009315 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 150340009316 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 150340009317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 150340009318 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 150340009319 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 150340009320 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 150340009321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 150340009322 non-specific DNA binding site [nucleotide binding]; other site 150340009323 salt bridge; other site 150340009324 sequence-specific DNA binding site [nucleotide binding]; other site 150340009325 Cupin domain; Region: Cupin_2; cl09118 150340009326 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 150340009327 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 150340009328 dimer interface [polypeptide binding]; other site 150340009329 glycine-pyridoxal phosphate binding site [chemical binding]; other site 150340009330 active site 150340009331 folate binding site [chemical binding]; other site 150340009332 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 150340009333 lipoyl attachment site [posttranslational modification]; other site 150340009334 glycine dehydrogenase; Provisional; Region: PRK05367 150340009335 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 150340009336 tetramer interface [polypeptide binding]; other site 150340009337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340009338 catalytic residue [active] 150340009339 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 150340009340 tetramer interface [polypeptide binding]; other site 150340009341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340009342 catalytic residue [active] 150340009343 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 150340009344 Uncharacterized conserved protein [Function unknown]; Region: COG2128 150340009345 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 150340009346 Helix-turn-helix domain; Region: HTH_18; pfam12833 150340009347 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 150340009348 active site 150340009349 substrate binding site [chemical binding]; other site 150340009350 catalytic site [active] 150340009351 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 150340009352 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 150340009353 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 150340009354 Walker A/P-loop; other site 150340009355 ATP binding site [chemical binding]; other site 150340009356 Q-loop/lid; other site 150340009357 ABC transporter signature motif; other site 150340009358 Walker B; other site 150340009359 D-loop; other site 150340009360 H-loop/switch region; other site 150340009361 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 150340009362 thioester reductase domain; Region: Thioester-redct; TIGR01746 150340009363 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among Gram-...; Region: OMPLA; cd00541 150340009364 dimerization interface [polypeptide binding]; other site 150340009365 substrate binding site [chemical binding]; other site 150340009366 active site 150340009367 calcium binding site [ion binding]; other site 150340009368 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 150340009369 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 150340009370 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 150340009371 DNA binding residues [nucleotide binding] 150340009372 putative dimer interface [polypeptide binding]; other site 150340009373 putative metal binding residues [ion binding]; other site 150340009374 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 150340009375 active site 150340009376 catalytic residues [active] 150340009377 metal binding site [ion binding]; metal-binding site 150340009378 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 150340009379 Protein of unknown function (DUF2999); Region: DUF2999; pfam11212 150340009380 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 150340009381 dimerization interface [polypeptide binding]; other site 150340009382 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; cl01238 150340009383 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 150340009384 MgtE intracellular N domain; Region: MgtE_N; cl15244 150340009385 Divalent cation transporter; Region: MgtE; cl00786 150340009386 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 150340009387 Ligand Binding Site [chemical binding]; other site 150340009388 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 150340009389 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 150340009390 CoenzymeA binding site [chemical binding]; other site 150340009391 subunit interaction site [polypeptide binding]; other site 150340009392 PHB binding site; other site 150340009393 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 150340009394 dimer interface [polypeptide binding]; other site 150340009395 active site 150340009396 metal binding site [ion binding]; metal-binding site 150340009397 glutathione binding site [chemical binding]; other site 150340009398 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 150340009399 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 150340009400 FMN binding site [chemical binding]; other site 150340009401 active site 150340009402 substrate binding site [chemical binding]; other site 150340009403 catalytic residue [active] 150340009404 Nitrogen fixation protein NifW; Region: NifW; cl03935 150340009405 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 150340009406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340009407 RES domain; Region: RES; cl02411 150340009408 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 150340009409 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 150340009410 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 150340009411 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 150340009412 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 150340009413 dimer interface [polypeptide binding]; other site 150340009414 active site 150340009415 heme binding site [chemical binding]; other site 150340009416 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 150340009417 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 150340009418 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 150340009419 active site 150340009420 FMN binding site [chemical binding]; other site 150340009421 substrate binding site [chemical binding]; other site 150340009422 3Fe-4S cluster binding site [ion binding]; other site 150340009423 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 150340009424 putative deacylase active site [active] 150340009425 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 150340009426 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 150340009427 NAD(P) binding site [chemical binding]; other site 150340009428 catalytic residues [active] 150340009429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340009430 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 150340009431 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_36; cd04695 150340009432 nudix motif; other site 150340009433 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 150340009434 EamA-like transporter family; Region: EamA; cl01037 150340009435 EamA-like transporter family; Region: EamA; cl01037 150340009436 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 150340009437 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 150340009438 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 150340009439 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 150340009440 active site 150340009441 Zn binding site [ion binding]; other site 150340009442 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 150340009443 MAPEG family; Region: MAPEG; cl09190 150340009444 Predicted permeases [General function prediction only]; Region: RarD; COG2962 150340009445 EamA-like transporter family; Region: EamA; cl01037 150340009446 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 150340009447 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 150340009448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340009449 active site 150340009450 phosphorylation site [posttranslational modification] 150340009451 intermolecular recognition site; other site 150340009452 dimerization interface [polypeptide binding]; other site 150340009453 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 150340009454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340009455 active site 150340009456 phosphorylation site [posttranslational modification] 150340009457 intermolecular recognition site; other site 150340009458 dimerization interface [polypeptide binding]; other site 150340009459 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 150340009460 DNA binding residues [nucleotide binding] 150340009461 dimerization interface [polypeptide binding]; other site 150340009462 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340009463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340009464 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340009465 metal binding site [ion binding]; metal-binding site 150340009466 active site 150340009467 I-site; other site 150340009468 Response regulator receiver domain; Region: Response_reg; pfam00072 150340009469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340009470 active site 150340009471 phosphorylation site [posttranslational modification] 150340009472 intermolecular recognition site; other site 150340009473 dimerization interface [polypeptide binding]; other site 150340009474 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340009475 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 150340009476 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 150340009477 GTP/Mg2+ binding site [chemical binding]; other site 150340009478 G4 box; other site 150340009479 G5 box; other site 150340009480 G1 box; other site 150340009481 Switch I region; other site 150340009482 G2 box; other site 150340009483 G3 box; other site 150340009484 Switch II region; other site 150340009485 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 150340009486 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 150340009487 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 150340009488 catalytic residue [active] 150340009489 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 150340009490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340009491 ATP binding site [chemical binding]; other site 150340009492 Mg2+ binding site [ion binding]; other site 150340009493 G-X-G motif; other site 150340009494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340009495 active site 150340009496 phosphorylation site [posttranslational modification] 150340009497 intermolecular recognition site; other site 150340009498 dimerization interface [polypeptide binding]; other site 150340009499 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 150340009500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 150340009501 motif II; other site 150340009502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340009503 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 150340009504 Di-iron ligands [ion binding]; other site 150340009505 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 150340009506 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; cl15274 150340009507 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 150340009508 LemA family; Region: LemA; cl00742 150340009509 Peptidase family M48; Region: Peptidase_M48; cl12018 150340009510 Major Facilitator Superfamily; Region: MFS_1; pfam07690 150340009511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340009512 putative substrate translocation pore; other site 150340009513 VRR-NUC domain; Region: VRR_NUC; cl08494 150340009514 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 150340009515 lipid kinase; Reviewed; Region: PRK13054 150340009516 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 150340009517 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 150340009518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340009519 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 150340009520 putative substrate binding pocket [chemical binding]; other site 150340009521 putative dimerization interface [polypeptide binding]; other site 150340009522 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 150340009523 catalytic motif [active] 150340009524 Zn binding site [ion binding]; other site 150340009525 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 150340009526 metal ion-dependent adhesion site (MIDAS); other site 150340009527 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_BatA_type; cd01467 150340009528 metal ion-dependent adhesion site (MIDAS); other site 150340009529 Protein of unknown function DUF58; Region: DUF58; pfam01882 150340009530 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 150340009531 metal ion-dependent adhesion site (MIDAS); other site 150340009532 MoxR-like ATPases [General function prediction only]; Region: COG0714 150340009533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340009534 Walker A motif; other site 150340009535 ATP binding site [chemical binding]; other site 150340009536 Walker B motif; other site 150340009537 arginine finger; other site 150340009538 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340009539 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 150340009540 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 150340009541 FeS/SAM binding site; other site 150340009542 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 150340009543 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 150340009544 Sulfatase; Region: Sulfatase; cl10460 150340009545 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340009546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340009547 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340009548 dimerization interface [polypeptide binding]; other site 150340009549 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 150340009550 Sulfatase; Region: Sulfatase; cl10460 150340009551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340009552 DNA binding site [nucleotide binding] 150340009553 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 150340009554 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 150340009555 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340009556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340009557 dimer interface [polypeptide binding]; other site 150340009558 phosphorylation site [posttranslational modification] 150340009559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340009560 ATP binding site [chemical binding]; other site 150340009561 Mg2+ binding site [ion binding]; other site 150340009562 G-X-G motif; other site 150340009563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340009564 active site 150340009565 phosphorylation site [posttranslational modification] 150340009566 intermolecular recognition site; other site 150340009567 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 150340009568 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 150340009569 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 150340009570 putative ligand binding site [chemical binding]; other site 150340009571 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 150340009572 active site 150340009573 dimer interfaces [polypeptide binding]; other site 150340009574 catalytic residues [active] 150340009575 DNA helicase IV; Provisional; Region: helD; PRK11054 150340009576 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 150340009577 UvrD/REP helicase; Region: UvrD-helicase; cl14126 150340009578 hypothetical membrane protein, TIGR01666; Region: YCCS 150340009579 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 150340009580 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009581 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009582 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009583 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009584 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009585 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009586 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009587 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009588 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009589 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009590 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009591 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009592 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009593 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009594 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009595 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009596 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 150340009597 type 1 secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 150340009598 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 150340009599 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 150340009600 N-terminal plug; other site 150340009601 ligand-binding site [chemical binding]; other site 150340009602 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340009603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340009604 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 150340009605 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 150340009606 DNA binding residues [nucleotide binding] 150340009607 dimer interface [polypeptide binding]; other site 150340009608 copper binding site [ion binding]; other site 150340009609 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 150340009610 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 150340009611 Walker A/P-loop; other site 150340009612 ATP binding site [chemical binding]; other site 150340009613 Q-loop/lid; other site 150340009614 ABC transporter signature motif; other site 150340009615 Walker B; other site 150340009616 D-loop; other site 150340009617 H-loop/switch region; other site 150340009618 ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605 150340009619 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 150340009620 ABC-ATPase subunit interface; other site 150340009621 dimer interface [polypeptide binding]; other site 150340009622 putative PBP binding regions; other site 150340009623 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 150340009624 ABC-ATPase subunit interface; other site 150340009625 dimer interface [polypeptide binding]; other site 150340009626 putative PBP binding regions; other site 150340009627 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 150340009628 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 150340009629 putative ligand binding residues [chemical binding]; other site 150340009630 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 150340009631 ligand binding site [chemical binding]; other site 150340009632 flexible hinge region; other site 150340009633 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 150340009634 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 150340009635 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 150340009636 transcriptional repressor RbsR; Provisional; Region: PRK10423 150340009637 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 150340009638 DNA binding site [nucleotide binding] 150340009639 domain linker motif; other site 150340009640 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 150340009641 dimerization interface [polypeptide binding]; other site 150340009642 ligand binding site [chemical binding]; other site 150340009643 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 150340009644 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 150340009645 substrate binding site [chemical binding]; other site 150340009646 dimer interface [polypeptide binding]; other site 150340009647 ATP binding site [chemical binding]; other site 150340009648 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 150340009649 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 150340009650 ligand binding site [chemical binding]; other site 150340009651 dimerization interface [polypeptide binding]; other site 150340009652 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 150340009653 TM-ABC transporter signature motif; other site 150340009654 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 150340009655 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 150340009656 Walker A/P-loop; other site 150340009657 ATP binding site [chemical binding]; other site 150340009658 Q-loop/lid; other site 150340009659 ABC transporter signature motif; other site 150340009660 Walker B; other site 150340009661 D-loop; other site 150340009662 H-loop/switch region; other site 150340009663 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 150340009664 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 150340009665 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 150340009666 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340009667 metal binding site [ion binding]; metal-binding site 150340009668 active site 150340009669 I-site; other site 150340009670 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340009671 U5 snRNP spliceosome subunit [RNA processing and modification]; Region: PRP8; COG5178 150340009672 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 150340009673 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 150340009674 lipoprotein LpqB; Provisional; Region: PRK13616 150340009675 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 150340009676 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 150340009677 glutamate dehydrogenase; Provisional; Region: PRK09414 150340009678 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 150340009679 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 150340009680 NAD(P) binding site [chemical binding]; other site 150340009681 OsmC-like protein; Region: OsmC; cl00767 150340009682 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340009683 dimer interface [polypeptide binding]; other site 150340009684 phosphorylation site [posttranslational modification] 150340009685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340009686 ATP binding site [chemical binding]; other site 150340009687 Mg2+ binding site [ion binding]; other site 150340009688 G-X-G motif; other site 150340009689 Response regulator receiver domain; Region: Response_reg; pfam00072 150340009690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340009691 active site 150340009692 phosphorylation site [posttranslational modification] 150340009693 intermolecular recognition site; other site 150340009694 dimerization interface [polypeptide binding]; other site 150340009695 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 150340009696 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 150340009697 CHASE4 domain; Region: CHASE4; cl01308 150340009698 PAS domain S-box; Region: sensory_box; TIGR00229 150340009699 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340009700 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340009701 metal binding site [ion binding]; metal-binding site 150340009702 active site 150340009703 I-site; other site 150340009704 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340009705 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 150340009706 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 150340009707 dimer interface [polypeptide binding]; other site 150340009708 active site residues [active] 150340009709 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 150340009710 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 150340009711 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 150340009712 dimer interface [polypeptide binding]; other site 150340009713 FMN binding site [chemical binding]; other site 150340009714 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 150340009715 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340009716 Walker A/P-loop; other site 150340009717 ATP binding site [chemical binding]; other site 150340009718 Q-loop/lid; other site 150340009719 ABC transporter signature motif; other site 150340009720 Walker B; other site 150340009721 D-loop; other site 150340009722 H-loop/switch region; other site 150340009723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340009724 dimer interface [polypeptide binding]; other site 150340009725 conserved gate region; other site 150340009726 putative PBP binding loops; other site 150340009727 ABC-ATPase subunit interface; other site 150340009728 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 150340009729 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 150340009730 choline dehydrogenase; Validated; Region: PRK02106 150340009731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340009732 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 150340009733 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 150340009734 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 150340009735 tetrameric interface [polypeptide binding]; other site 150340009736 NAD binding site [chemical binding]; other site 150340009737 catalytic residues [active] 150340009738 transcriptional regulator BetI; Validated; Region: PRK00767 150340009739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 150340009740 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340009741 metal binding site [ion binding]; metal-binding site 150340009742 active site 150340009743 I-site; other site 150340009744 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 150340009745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340009746 NAD(P) binding site [chemical binding]; other site 150340009747 active site 150340009748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340009749 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 150340009750 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 150340009751 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 150340009752 substrate binding site [chemical binding]; other site 150340009753 oxyanion hole (OAH) forming residues; other site 150340009754 trimer interface [polypeptide binding]; other site 150340009755 enoyl-CoA hydratase; Provisional; Region: PRK09076 150340009756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 150340009757 substrate binding site [chemical binding]; other site 150340009758 oxyanion hole (OAH) forming residues; other site 150340009759 trimer interface [polypeptide binding]; other site 150340009760 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 150340009761 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 150340009762 substrate binding pocket [chemical binding]; other site 150340009763 FAD binding site [chemical binding]; other site 150340009764 catalytic base [active] 150340009765 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 150340009766 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 150340009767 tetrameric interface [polypeptide binding]; other site 150340009768 NAD binding site [chemical binding]; other site 150340009769 catalytic residues [active] 150340009770 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 150340009771 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 150340009772 dimer interface [polypeptide binding]; other site 150340009773 active site 150340009774 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 150340009775 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 150340009776 DNA binding residues [nucleotide binding] 150340009777 putative dimer interface [polypeptide binding]; other site 150340009778 isovaleryl-CoA dehydrogenase; Region: PLN02519 150340009779 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 150340009780 substrate binding site [chemical binding]; other site 150340009781 FAD binding site [chemical binding]; other site 150340009782 catalytic base [active] 150340009783 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 150340009784 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 150340009785 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 150340009786 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 150340009787 enoyl-CoA hydratase; Provisional; Region: PRK05995 150340009788 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 150340009789 substrate binding site [chemical binding]; other site 150340009790 oxyanion hole (OAH) forming residues; other site 150340009791 trimer interface [polypeptide binding]; other site 150340009792 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 150340009793 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 150340009794 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 150340009795 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 150340009796 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 150340009797 carboxyltransferase (CT) interaction site; other site 150340009798 biotinylation site [posttranslational modification]; other site 150340009799 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 150340009800 active site 150340009801 catalytic residues [active] 150340009802 metal binding site [ion binding]; metal-binding site 150340009803 PAS fold; Region: PAS_4; pfam08448 150340009804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 150340009805 putative active site [active] 150340009806 heme pocket [chemical binding]; other site 150340009807 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 150340009808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340009809 dimer interface [polypeptide binding]; other site 150340009810 phosphorylation site [posttranslational modification] 150340009811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340009812 ATP binding site [chemical binding]; other site 150340009813 Mg2+ binding site [ion binding]; other site 150340009814 G-X-G motif; other site 150340009815 Response regulator receiver domain; Region: Response_reg; pfam00072 150340009816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340009817 active site 150340009818 phosphorylation site [posttranslational modification] 150340009819 intermolecular recognition site; other site 150340009820 dimerization interface [polypeptide binding]; other site 150340009821 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 150340009822 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 150340009823 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 150340009824 active site 150340009825 substrate binding site [chemical binding]; other site 150340009826 trimer interface [polypeptide binding]; other site 150340009827 CoA binding site [chemical binding]; other site 150340009828 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 150340009829 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340009830 DNA-binding site [nucleotide binding]; DNA binding site 150340009831 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 150340009832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340009833 homodimer interface [polypeptide binding]; other site 150340009834 catalytic residue [active] 150340009835 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 150340009836 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 150340009837 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 150340009838 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 150340009839 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 150340009840 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 150340009841 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 150340009842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 150340009843 motif II; other site 150340009844 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 150340009845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340009846 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340009847 dimerization interface [polypeptide binding]; other site 150340009848 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 150340009849 acetolactate synthase; Reviewed; Region: PRK08617 150340009850 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 150340009851 PYR/PP interface [polypeptide binding]; other site 150340009852 dimer interface [polypeptide binding]; other site 150340009853 TPP binding site [chemical binding]; other site 150340009854 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 150340009855 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 150340009856 TPP-binding site [chemical binding]; other site 150340009857 dimer interface [polypeptide binding]; other site 150340009858 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 150340009859 classical (c) SDRs; Region: SDR_c; cd05233 150340009860 NAD(P) binding site [chemical binding]; other site 150340009861 active site 150340009862 BCCT family transporter; Region: BCCT; cl00569 150340009863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340009864 S-adenosylmethionine binding site [chemical binding]; other site 150340009865 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 150340009866 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 150340009867 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 150340009868 Walker A/P-loop; other site 150340009869 ATP binding site [chemical binding]; other site 150340009870 Q-loop/lid; other site 150340009871 ABC transporter signature motif; other site 150340009872 Walker B; other site 150340009873 D-loop; other site 150340009874 H-loop/switch region; other site 150340009875 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 150340009876 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 150340009877 putative ligand binding site [chemical binding]; other site 150340009878 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 150340009879 TM-ABC transporter signature motif; other site 150340009880 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 150340009881 TM-ABC transporter signature motif; other site 150340009882 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 150340009883 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 150340009884 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 150340009885 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 150340009886 Walker A/P-loop; other site 150340009887 ATP binding site [chemical binding]; other site 150340009888 Q-loop/lid; other site 150340009889 ABC transporter signature motif; other site 150340009890 Walker B; other site 150340009891 D-loop; other site 150340009892 H-loop/switch region; other site 150340009893 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 150340009894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340009895 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 150340009896 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 150340009897 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 150340009898 Ligand binding site [chemical binding]; other site 150340009899 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 150340009900 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 150340009901 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 150340009902 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 150340009903 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 150340009904 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 150340009905 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340009906 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 150340009907 active site turn [active] 150340009908 phosphorylation site [posttranslational modification] 150340009909 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 150340009910 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 150340009911 NAD binding site [chemical binding]; other site 150340009912 sugar binding site [chemical binding]; other site 150340009913 divalent metal binding site [ion binding]; other site 150340009914 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 150340009915 dimer interface [polypeptide binding]; other site 150340009916 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 150340009917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340009918 DNA-binding site [nucleotide binding]; DNA binding site 150340009919 UTRA domain; Region: UTRA; cl01230 150340009920 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 150340009921 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 150340009922 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 150340009923 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 150340009924 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 150340009925 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 150340009926 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 150340009927 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 150340009928 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 150340009929 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 150340009930 universal stress protein UspE; Provisional; Region: PRK11175 150340009931 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 150340009932 Ligand Binding Site [chemical binding]; other site 150340009933 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 150340009934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340009935 NAD(P) binding site [chemical binding]; other site 150340009936 active site 150340009937 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340009938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340009939 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340009940 putative effector binding pocket; other site 150340009941 dimerization interface [polypeptide binding]; other site 150340009942 Cupin domain; Region: Cupin_2; cl09118 150340009943 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340009944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340009945 Major Facilitator Superfamily; Region: MFS_1; pfam07690 150340009946 putative substrate translocation pore; other site 150340009947 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 150340009948 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 150340009949 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 150340009950 Bacterial protein of unknown function (DUF876); Region: DUF876; cl01406 150340009951 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 150340009952 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 150340009953 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 150340009954 phosphopeptide binding site; other site 150340009955 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 150340009956 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 150340009957 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 150340009958 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 150340009959 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 150340009960 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 150340009961 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 150340009962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340009963 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 150340009964 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 150340009965 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 150340009966 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 150340009967 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 150340009968 Protein of unknown function (DUF877); Region: DUF877; pfam05943 150340009969 Protein of unknown function (DUF770); Region: DUF770; cl01402 150340009970 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 150340009971 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 150340009972 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 150340009973 Catalytic domain of Protein Kinases; Region: PKc; cd00180 150340009974 active site 150340009975 ATP binding site [chemical binding]; other site 150340009976 substrate binding site [chemical binding]; other site 150340009977 activation loop (A-loop); other site 150340009978 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 150340009979 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 150340009980 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 150340009981 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 150340009982 Protein of unknown function (DUF796); Region: DUF796; cl01226 150340009983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340009984 Walker A motif; other site 150340009985 ATP binding site [chemical binding]; other site 150340009986 Walker B motif; other site 150340009987 arginine finger; other site 150340009988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340009989 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 150340009990 Walker A motif; other site 150340009991 ATP binding site [chemical binding]; other site 150340009992 Walker B motif; other site 150340009993 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 150340009994 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 150340009995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340009996 Walker A motif; other site 150340009997 ATP binding site [chemical binding]; other site 150340009998 Walker B motif; other site 150340009999 arginine finger; other site 150340010000 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340010001 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340010002 ligand binding site [chemical binding]; other site 150340010003 putative peptidase; Provisional; Region: PRK11649 150340010004 Peptidase family M23; Region: Peptidase_M23; pfam01551 150340010005 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340010006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010007 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340010008 putative effector binding pocket; other site 150340010009 dimerization interface [polypeptide binding]; other site 150340010010 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 150340010011 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 150340010012 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 150340010013 dimer interface [polypeptide binding]; other site 150340010014 PYR/PP interface [polypeptide binding]; other site 150340010015 TPP binding site [chemical binding]; other site 150340010016 substrate binding site [chemical binding]; other site 150340010017 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 150340010018 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 150340010019 TPP-binding site [chemical binding]; other site 150340010020 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 150340010021 trimer interface [polypeptide binding]; other site 150340010022 active site 150340010023 substrate binding site [chemical binding]; other site 150340010024 CoA binding site [chemical binding]; other site 150340010025 Beta-lactamase; Region: Beta-lactamase; cl01009 150340010026 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 150340010027 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 150340010028 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340010029 DNA-binding site [nucleotide binding]; DNA binding site 150340010030 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 150340010031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340010032 homodimer interface [polypeptide binding]; other site 150340010033 catalytic residue [active] 150340010034 Equine herpesvirus glycoprotein gp2; Region: Herpes_gp2; pfam05955 150340010035 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 150340010036 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 150340010037 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 150340010038 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 150340010039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340010040 binding surface 150340010041 TPR motif; other site 150340010042 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 150340010043 FAD binding domain; Region: FAD_binding_4; pfam01565 150340010044 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 150340010045 active site 150340010046 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 150340010047 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 150340010048 active site 150340010049 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 150340010050 putative carbohydrate kinase; Provisional; Region: PRK10565 150340010051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 150340010052 putative substrate binding site [chemical binding]; other site 150340010053 putative ATP binding site [chemical binding]; other site 150340010054 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340010055 PAS fold; Region: PAS_4; pfam08448 150340010056 Response regulator receiver domain; Region: Response_reg; pfam00072 150340010057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340010058 active site 150340010059 phosphorylation site [posttranslational modification] 150340010060 intermolecular recognition site; other site 150340010061 dimerization interface [polypeptide binding]; other site 150340010062 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 150340010063 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 150340010064 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 150340010065 active site 150340010066 catalytic tetrad [active] 150340010067 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 150340010068 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-...; Region: EriC; cd01031 150340010069 Cl- selectivity filter; other site 150340010070 Cl- binding residues [ion binding]; other site 150340010071 pore gating glutamate residue; other site 150340010072 dimer interface [polypeptide binding]; other site 150340010073 H+/Cl- coupling transport residue; other site 150340010074 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 150340010075 C4-dicarboxylate transporter/malic acid transport protein; Region: C4dic_mal_tran; pfam03595 150340010076 gating phenylalanine in ion channel; other site 150340010077 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 150340010078 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 150340010079 homodecamer interface [polypeptide binding]; other site 150340010080 GTP cyclohydrolase I; Provisional; Region: PLN03044 150340010081 active site 150340010082 putative catalytic site residues [active] 150340010083 zinc binding site [ion binding]; other site 150340010084 GTP-CH-I/GFRP interaction surface; other site 150340010085 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 150340010086 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 150340010087 dimer interface [polypeptide binding]; other site 150340010088 putative functional site; other site 150340010089 putative MPT binding site; other site 150340010090 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 150340010091 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 150340010092 ATP binding site [chemical binding]; other site 150340010093 substrate interface [chemical binding]; other site 150340010094 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 150340010095 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 150340010096 active site residue [active] 150340010097 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 150340010098 active site residue [active] 150340010099 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340010100 metal binding site [ion binding]; metal-binding site 150340010101 active site 150340010102 I-site; other site 150340010103 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340010104 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 150340010105 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 150340010106 transaldolase-like protein; Provisional; Region: PTZ00411 150340010107 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 150340010108 active site 150340010109 dimer interface [polypeptide binding]; other site 150340010110 catalytic residue [active] 150340010111 transketolase; Reviewed; Region: PRK12753 150340010112 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 150340010113 TPP-binding site [chemical binding]; other site 150340010114 dimer interface [polypeptide binding]; other site 150340010115 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 150340010116 PYR/PP interface [polypeptide binding]; other site 150340010117 dimer interface [polypeptide binding]; other site 150340010118 TPP binding site [chemical binding]; other site 150340010119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 150340010120 PAS domain S-box; Region: sensory_box; TIGR00229 150340010121 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340010122 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340010123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340010124 Major Facilitator Superfamily; Region: MFS_1; pfam07690 150340010125 putative substrate translocation pore; other site 150340010126 NeuB family; Region: NeuB; cl00496 150340010127 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 150340010128 Surface antigen; Region: Surface_Ag_2; cl01155 150340010129 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340010130 ligand binding site [chemical binding]; other site 150340010131 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 150340010132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 150340010133 motif II; other site 150340010134 RF-1 domain; Region: RF-1; cl02875 150340010135 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 150340010136 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340010137 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340010138 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340010139 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 150340010140 Protein export membrane protein; Region: SecD_SecF; cl14618 150340010141 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 150340010142 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 150340010143 catalytic motif [active] 150340010144 Zn binding site [ion binding]; other site 150340010145 peptidase T; Region: peptidase-T; TIGR01882 150340010146 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 150340010147 metal binding site [ion binding]; metal-binding site 150340010148 dimer interface [polypeptide binding]; other site 150340010149 transcriptional regulator NarP; Provisional; Region: PRK10403 150340010150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340010151 active site 150340010152 phosphorylation site [posttranslational modification] 150340010153 intermolecular recognition site; other site 150340010154 dimerization interface [polypeptide binding]; other site 150340010155 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 150340010156 DNA binding residues [nucleotide binding] 150340010157 dimerization interface [polypeptide binding]; other site 150340010158 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 150340010159 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340010160 Histidine kinase; Region: HisKA_3; pfam07730 150340010161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340010162 ATP binding site [chemical binding]; other site 150340010163 Mg2+ binding site [ion binding]; other site 150340010164 G-X-G motif; other site 150340010165 ferredoxin-type protein; Provisional; Region: PRK10194 150340010166 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 150340010167 NapD protein; Region: NapD; cl01163 150340010168 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 150340010169 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 150340010170 [4Fe-4S] binding site [ion binding]; other site 150340010171 molybdopterin cofactor binding site; other site 150340010172 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 150340010173 molybdopterin cofactor binding site; other site 150340010174 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 150340010175 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl09485 150340010176 Protein of unknown function (Duf2374); Region: DUF2374; cl09797 150340010177 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 150340010178 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 150340010179 Phasin protein; Region: Phasin_2; cl11491 150340010180 putative acyltransferase; Provisional; Region: PRK05790 150340010181 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 150340010182 dimer interface [polypeptide binding]; other site 150340010183 active site 150340010184 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 150340010185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340010186 NAD(P) binding site [chemical binding]; other site 150340010187 active site 150340010188 LysE type translocator; Region: LysE; cl00565 150340010189 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13021 150340010190 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 150340010191 Protein export membrane protein; Region: SecD_SecF; cl14618 150340010192 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933 150340010193 Protein export membrane protein; Region: SecD_SecF; cl14618 150340010194 Bacterial SH3 domain; Region: SH3_3; cl02551 150340010195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340010196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340010197 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 150340010198 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010199 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 150340010200 Flagellar protein YcgR; Region: YcgR_2; pfam12945 150340010201 PilZ domain; Region: PilZ; cl01260 150340010202 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 150340010203 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 150340010204 transcriptional regulator SlyA; Provisional; Region: PRK03573 150340010205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010206 LuxQ, periplasmic; Region: LuxQ-periplasm; pfam09308 150340010207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 150340010208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340010209 dimer interface [polypeptide binding]; other site 150340010210 phosphorylation site [posttranslational modification] 150340010211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340010212 ATP binding site [chemical binding]; other site 150340010213 Mg2+ binding site [ion binding]; other site 150340010214 G-X-G motif; other site 150340010215 Response regulator receiver domain; Region: Response_reg; pfam00072 150340010216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340010217 active site 150340010218 phosphorylation site [posttranslational modification] 150340010219 intermolecular recognition site; other site 150340010220 dimerization interface [polypeptide binding]; other site 150340010221 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 150340010222 Periplasmic binding protein (LuxP) of autoinducer-2 (AI-2) receptor LuxPQ from Vibrio harveyi and its close homologs; Region: PBP1_LuxPQ_Quorum_Sensing; cd06303 150340010223 ligand binding site [chemical binding]; other site 150340010224 subunit interaction site [polypeptide binding]; other site 150340010225 calcium binding site [ion binding]; other site 150340010226 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 150340010227 GIY-YIG motif/motif A; other site 150340010228 putative active site [active] 150340010229 putative metal binding site [ion binding]; other site 150340010230 Protein of unknown function, DUF480; Region: DUF480; cl01209 150340010231 hypothetical protein; Provisional; Region: PRK11239 150340010232 Protein of unknown function (DUF496); Region: DUF496; cl09955 150340010233 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 150340010234 MatE; Region: MatE; cl10513 150340010235 MatE; Region: MatE; cl10513 150340010236 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 150340010237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 150340010238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340010239 ATP binding site [chemical binding]; other site 150340010240 Mg2+ binding site [ion binding]; other site 150340010241 G-X-G motif; other site 150340010242 Response regulator receiver domain; Region: Response_reg; pfam00072 150340010243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340010244 active site 150340010245 phosphorylation site [posttranslational modification] 150340010246 intermolecular recognition site; other site 150340010247 dimerization interface [polypeptide binding]; other site 150340010248 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 150340010249 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 150340010250 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 150340010251 LysE type translocator; Region: LysE; cl00565 150340010252 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340010253 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010254 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 150340010255 substrate binding pocket [chemical binding]; other site 150340010256 dimerization interface [polypeptide binding]; other site 150340010257 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 150340010258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010259 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 150340010260 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 150340010261 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340010262 DNA-binding site [nucleotide binding]; DNA binding site 150340010263 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 150340010264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340010265 homodimer interface [polypeptide binding]; other site 150340010266 catalytic residue [active] 150340010267 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 150340010268 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340010269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 150340010270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340010271 ATP binding site [chemical binding]; other site 150340010272 Mg2+ binding site [ion binding]; other site 150340010273 G-X-G motif; other site 150340010274 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 150340010275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340010276 active site 150340010277 phosphorylation site [posttranslational modification] 150340010278 intermolecular recognition site; other site 150340010279 dimerization interface [polypeptide binding]; other site 150340010280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340010281 DNA binding site [nucleotide binding] 150340010282 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 150340010283 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340010284 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340010285 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 150340010286 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 150340010287 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 150340010288 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 150340010289 MgtE intracellular N domain; Region: MgtE_N; cl15244 150340010290 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 150340010291 Divalent cation transporter; Region: MgtE; cl00786 150340010292 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 150340010293 Sodium:solute symporter family; Region: SSF; cl00456 150340010294 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 150340010295 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 150340010296 active site 150340010297 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 150340010298 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 150340010299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 150340010300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340010301 putative substrate translocation pore; other site 150340010302 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 150340010303 putative acyl-acceptor binding pocket; other site 150340010304 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 150340010305 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 150340010306 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 150340010307 catalytic residues [active] 150340010308 dimer interface [polypeptide binding]; other site 150340010309 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 150340010310 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 150340010311 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 150340010312 catalytic residues [active] 150340010313 hinge region; other site 150340010314 alpha helical domain; other site 150340010315 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 150340010316 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 150340010317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340010318 active site 150340010319 phosphorylation site [posttranslational modification] 150340010320 intermolecular recognition site; other site 150340010321 dimerization interface [polypeptide binding]; other site 150340010322 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340010323 DNA binding site [nucleotide binding] 150340010324 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 150340010325 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340010326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 150340010327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340010328 ATP binding site [chemical binding]; other site 150340010329 Mg2+ binding site [ion binding]; other site 150340010330 G-X-G motif; other site 150340010331 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 150340010332 putative metal dependent hydrolase; Provisional; Region: PRK11598 150340010333 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 150340010334 Sulfatase; Region: Sulfatase; cl10460 150340010335 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 150340010336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340010337 hypothetical protein; Provisional; Region: PRK11770 150340010338 Domain of unknown function (DUF307); Region: DUF307; pfam03733 150340010339 Domain of unknown function (DUF307); Region: DUF307; pfam03733 150340010340 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 150340010341 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 150340010342 active site 150340010343 nucleophile elbow; other site 150340010344 Pirin-related protein [General function prediction only]; Region: COG1741 150340010345 Cupin domain; Region: Cupin_2; cl09118 150340010346 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 150340010347 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 150340010348 DNA-binding site [nucleotide binding]; DNA binding site 150340010349 RNA-binding motif; other site 150340010350 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 150340010351 active site 150340010352 purine riboside binding site [chemical binding]; other site 150340010353 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 150340010354 catalytic triad [active] 150340010355 dimer interface [polypeptide binding]; other site 150340010356 Sporulation related domain; Region: SPOR; cl10051 150340010357 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 150340010358 Beta-lactamase; Region: Beta-lactamase; cl01009 150340010359 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 150340010360 putative S-transferase; Provisional; Region: PRK11752 150340010361 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen...; Region: GST_N_Ure2p_like; cd03048 150340010362 C-terminal domain interface [polypeptide binding]; other site 150340010363 GSH binding site (G-site) [chemical binding]; other site 150340010364 dimer interface [polypeptide binding]; other site 150340010365 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 150340010366 dimer interface [polypeptide binding]; other site 150340010367 N-terminal domain interface [polypeptide binding]; other site 150340010368 active site 150340010369 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 150340010370 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 150340010371 substrate binding [chemical binding]; other site 150340010372 active site 150340010373 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 150340010374 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 150340010375 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 150340010376 putative substrate binding site [chemical binding]; other site 150340010377 putative ATP binding site [chemical binding]; other site 150340010378 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 150340010379 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 150340010380 active site turn [active] 150340010381 phosphorylation site [posttranslational modification] 150340010382 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340010383 Transcriptional regulators [Transcription]; Region: PurR; COG1609 150340010384 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 150340010385 DNA binding site [nucleotide binding] 150340010386 domain linker motif; other site 150340010387 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 150340010388 dimerization interface [polypeptide binding]; other site 150340010389 ligand binding site [chemical binding]; other site 150340010390 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel beta-...; Region: Maltoporin-like; cd01346 150340010391 trimer interface; other site 150340010392 sugar binding site [chemical binding]; other site 150340010393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340010394 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 150340010395 NAD(P) binding site [chemical binding]; other site 150340010396 active site 150340010397 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cl00462 150340010398 Periplasmic binding protein TroA_c. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145 150340010399 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 150340010400 putative ligand binding site [chemical binding]; other site 150340010401 organic solvent tolerance protein; Provisional; Region: PRK04423 150340010402 Cupin domain; Region: Cupin_2; cl09118 150340010403 Cupin domain; Region: Cupin_2; cl09118 150340010404 Protein of unknown function (DUF465); Region: DUF465; cl01070 150340010405 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340010406 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340010407 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340010408 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 150340010409 aspartate aminotransferase; Provisional; Region: PRK07681 150340010410 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 150340010411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340010412 homodimer interface [polypeptide binding]; other site 150340010413 catalytic residue [active] 150340010414 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 150340010415 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 150340010416 N-glycosyltransferase; Provisional; Region: PRK11204 150340010417 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 150340010418 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 150340010419 DXD motif; other site 150340010420 DNA polymerase II large subunit; Provisional; Region: PRK14714 150340010421 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 150340010422 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 150340010423 DEAD-like helicases superfamily; Region: DEXDc; smart00487 150340010424 ATP binding site [chemical binding]; other site 150340010425 Mg++ binding site [ion binding]; other site 150340010426 motif III; other site 150340010427 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340010428 nucleotide binding region [chemical binding]; other site 150340010429 ATP-binding site [chemical binding]; other site 150340010430 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 150340010431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340010432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340010434 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340010435 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010436 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340010437 putative effector binding pocket; other site 150340010438 dimerization interface [polypeptide binding]; other site 150340010439 glutaredoxin 2; Provisional; Region: PRK10387 150340010440 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 150340010441 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 150340010442 dimer interface [polypeptide binding]; other site 150340010443 substrate binding pocket (H-site) [chemical binding]; other site 150340010444 N-terminal domain interface [polypeptide binding]; other site 150340010445 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 150340010446 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 150340010447 FMN binding site [chemical binding]; other site 150340010448 active site 150340010449 substrate binding site [chemical binding]; other site 150340010450 catalytic residue [active] 150340010451 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 150340010452 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 150340010453 putative NAD(P) binding site [chemical binding]; other site 150340010454 catalytic Zn binding site [ion binding]; other site 150340010455 Cupin domain; Region: Cupin_2; cl09118 150340010456 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 150340010457 classical (c) SDRs; Region: SDR_c; cd05233 150340010458 NAD(P) binding site [chemical binding]; other site 150340010459 active site 150340010460 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 150340010461 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340010462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340010463 DctM-like transporters; Region: DctM; pfam06808 150340010464 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340010465 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 150340010466 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 150340010467 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340010468 DNA-binding site [nucleotide binding]; DNA binding site 150340010469 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 150340010470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340010471 homodimer interface [polypeptide binding]; other site 150340010472 catalytic residue [active] 150340010473 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 150340010474 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 150340010475 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 150340010476 active site 150340010477 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 150340010478 A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the...; Region: M14_ASTE_ASPA_like_2; cd06252 150340010479 putative active site [active] 150340010480 Zn-binding site [ion binding]; other site 150340010481 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 150340010482 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 150340010483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010484 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 150340010485 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 150340010486 tetramerization interface [polypeptide binding]; other site 150340010487 NAD(P) binding site [chemical binding]; other site 150340010488 catalytic residues [active] 150340010489 hypothetical protein; Provisional; Region: PRK07482 150340010490 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 150340010491 inhibitor-cofactor binding pocket; inhibition site 150340010492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340010493 catalytic residue [active] 150340010494 hypothetical protein; Provisional; Region: PRK06815 150340010495 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 150340010496 tetramer interface [polypeptide binding]; other site 150340010497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340010498 catalytic residue [active] 150340010499 ectoine utilization protein EutC; Validated; Region: PRK08291 150340010500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340010501 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 150340010502 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 150340010503 LysE type translocator; Region: LysE; cl00565 150340010504 Ribosome recycling factor; Region: RRF_GI; pfam12614 150340010505 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340010506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010507 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 150340010508 dimerization interface [polypeptide binding]; other site 150340010509 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 150340010510 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 150340010511 GDP-binding site [chemical binding]; other site 150340010512 ACT binding site; other site 150340010513 IMP binding site; other site 150340010514 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cd00411 150340010515 active site/substrate binding site [active] 150340010516 tetramer interface [polypeptide binding]; other site 150340010517 Domain of unknown function (DUF299); Region: DUF299; cl00780 150340010518 phosphoenolpyruvate synthase; Validated; Region: PRK06464 150340010519 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 150340010520 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 150340010521 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 150340010522 Family of unknown function (DUF500); Region: DUF500; cl01109 150340010523 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 150340010524 DNA binding residues [nucleotide binding] 150340010525 dimerization interface [polypeptide binding]; other site 150340010526 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 150340010527 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 150340010528 active site 150340010529 HIGH motif; other site 150340010530 dimer interface [polypeptide binding]; other site 150340010531 KMSKS motif; other site 150340010532 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 150340010533 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340010534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010535 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340010536 dimerization interface [polypeptide binding]; other site 150340010537 putative effector binding pocket; other site 150340010538 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 150340010539 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 150340010540 NodT family; Region: outer_NodT; TIGR01845 150340010541 Outer membrane efflux protein; Region: OEP; pfam02321 150340010542 Outer membrane efflux protein; Region: OEP; pfam02321 150340010543 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 150340010544 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 150340010545 BCCT family transporter; Region: BCCT; cl00569 150340010546 transcriptional regulator protein; Region: phnR; TIGR03337 150340010547 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340010548 DNA-binding site [nucleotide binding]; DNA binding site 150340010549 UTRA domain; Region: UTRA; cl01230 150340010550 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340010551 Sulfatase; Region: Sulfatase; cl10460 150340010552 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 150340010553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340010554 dimer interface [polypeptide binding]; other site 150340010555 conserved gate region; other site 150340010556 putative PBP binding loops; other site 150340010557 ABC-ATPase subunit interface; other site 150340010558 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 150340010559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340010560 dimer interface [polypeptide binding]; other site 150340010561 conserved gate region; other site 150340010562 putative PBP binding loops; other site 150340010563 ABC-ATPase subunit interface; other site 150340010564 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 150340010565 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340010566 Walker A/P-loop; other site 150340010567 ATP binding site [chemical binding]; other site 150340010568 Q-loop/lid; other site 150340010569 ABC transporter signature motif; other site 150340010570 Walker B; other site 150340010571 D-loop; other site 150340010572 H-loop/switch region; other site 150340010573 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 150340010574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 150340010575 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 150340010576 Protein export membrane protein; Region: SecD_SecF; cl14618 150340010577 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 150340010578 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 150340010579 putative active site [active] 150340010580 catalytic site [active] 150340010581 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 150340010582 putative active site [active] 150340010583 catalytic site [active] 150340010584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340010585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340010586 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 150340010587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340010588 TPR motif; other site 150340010589 binding surface 150340010590 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 150340010591 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 150340010592 DNA binding residues [nucleotide binding] 150340010593 dimer interface [polypeptide binding]; other site 150340010594 [2Fe-2S] cluster binding site [ion binding]; other site 150340010595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340010596 H+ Antiporter protein; Region: 2A0121; TIGR00900 150340010597 putative substrate translocation pore; other site 150340010598 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 150340010599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010600 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340010601 dimerization interface [polypeptide binding]; other site 150340010602 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 150340010603 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism...; Region: L-Ala-DL-Glu_epimerase; cd03319 150340010604 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 150340010605 active site 150340010606 elongation factor G; Reviewed; Region: PRK13351 150340010607 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170 150340010608 G1 box; other site 150340010609 putative GEF interaction site [polypeptide binding]; other site 150340010610 GTP/Mg2+ binding site [chemical binding]; other site 150340010611 Switch I region; other site 150340010612 G2 box; other site 150340010613 G3 box; other site 150340010614 Switch II region; other site 150340010615 G4 box; other site 150340010616 G5 box; other site 150340010617 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 150340010618 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 150340010619 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 150340010620 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 150340010621 Protein of unknown function (DUF539); Region: DUF539; cl01129 150340010622 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 150340010623 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 150340010624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340010625 dimer interface [polypeptide binding]; other site 150340010626 conserved gate region; other site 150340010627 putative PBP binding loops; other site 150340010628 ABC-ATPase subunit interface; other site 150340010629 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 150340010630 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 150340010631 Walker A/P-loop; other site 150340010632 ATP binding site [chemical binding]; other site 150340010633 Q-loop/lid; other site 150340010634 ABC transporter signature motif; other site 150340010635 Walker B; other site 150340010636 D-loop; other site 150340010637 H-loop/switch region; other site 150340010638 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 150340010639 Uncharacterized lipoprotein NlpE involved in copper resistance; Region: NlpE; cl01138 150340010640 MltA-interacting protein MipA; Region: MipA; cl01504 150340010641 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 150340010642 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 150340010643 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 150340010644 Surface antigen; Region: Surface_Ag_2; cl01155 150340010645 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 150340010646 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340010648 dimerization interface [polypeptide binding]; other site 150340010649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340010650 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 150340010651 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 150340010652 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: PncB_like; cd01401 150340010653 active site 150340010654 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 150340010655 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 150340010656 Isochorismatase family; Region: Isochorismatase; pfam00857 150340010657 catalytic triad [active] 150340010658 metal binding site [ion binding]; metal-binding site 150340010659 conserved cis-peptide bond; other site 150340010660 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 150340010661 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 150340010662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010663 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 150340010664 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 150340010665 putative metal binding site [ion binding]; other site 150340010666 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 150340010667 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 150340010668 active site 150340010669 phosphorylation site [posttranslational modification] 150340010670 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340010671 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 150340010672 P-loop; other site 150340010673 active site 150340010674 phosphorylation site [posttranslational modification] 150340010675 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 150340010676 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 150340010677 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 150340010678 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 150340010679 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 150340010680 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 150340010681 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 150340010682 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 150340010683 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 150340010684 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 150340010685 Nitronate monooxygenase; Region: NMO; pfam03060 150340010686 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 150340010687 FMN binding site [chemical binding]; other site 150340010688 substrate binding site [chemical binding]; other site 150340010689 putative catalytic residue [active] 150340010690 ethanolamine permease; Region: 2A0305; TIGR00908 150340010691 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 150340010692 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 150340010693 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 150340010694 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205 150340010695 transcriptional regulator EutR; Provisional; Region: PRK10130 150340010696 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340010697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340010698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 150340010699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 150340010700 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 150340010701 active site 150340010702 metal binding site [ion binding]; metal-binding site 150340010703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340010704 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 150340010705 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 150340010706 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 150340010707 ring oligomerisation interface [polypeptide binding]; other site 150340010708 ATP/Mg binding site [chemical binding]; other site 150340010709 stacking interactions; other site 150340010710 hinge regions; other site 150340010711 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 150340010712 oligomerisation interface [polypeptide binding]; other site 150340010713 mobile loop; other site 150340010714 roof hairpin; other site 150340010715 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 150340010716 active site residue [active] 150340010717 Protein of unknown function (DUF3012); Region: DUF3012; pfam11216 150340010718 Protein of unknown function (DUF3012); Region: DUF3012; pfam11216 150340010719 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 150340010720 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal...; Region: IDI-2_FMN; cd02811 150340010721 homotetramer interface [polypeptide binding]; other site 150340010722 FMN binding site [chemical binding]; other site 150340010723 homodimer contacts [polypeptide binding]; other site 150340010724 putative active site [active] 150340010725 putative substrate binding site [chemical binding]; other site 150340010726 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 150340010727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340010728 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 150340010729 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 150340010730 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 150340010731 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 150340010732 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 150340010733 Rod binding protein; Region: Rod-binding; cl01626 150340010734 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 150340010735 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 150340010736 Flagellar L-ring protein; Region: FlgH; cl00905 150340010737 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 150340010738 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 150340010739 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 150340010740 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 150340010741 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 150340010742 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 150340010743 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 150340010744 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 150340010745 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 150340010746 Flagellar hook capping protein; Region: FlgD; cl04347 150340010747 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 150340010748 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 150340010749 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 150340010750 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 150340010751 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 150340010752 SAF domain; Region: SAF; cl00555 150340010753 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 150340010754 FlgN protein; Region: FlgN; cl09176 150340010755 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 150340010756 N-acetyl-D-glucosamine binding site [chemical binding]; other site 150340010757 catalytic residue [active] 150340010758 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686 150340010759 nudix motif; other site 150340010760 Domain of unknown function (DUF333); Region: DUF333; pfam03891 150340010761 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 150340010762 putative active site [active] 150340010763 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 150340010764 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 150340010765 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 150340010766 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 150340010767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 150340010768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340010770 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340010771 dimerization interface [polypeptide binding]; other site 150340010772 Phosphotransferase enzyme family; Region: APH; pfam01636 150340010773 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 150340010774 active site 150340010775 ATP binding site [chemical binding]; other site 150340010776 substrate binding site [chemical binding]; other site 150340010777 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 150340010778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010779 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 150340010780 dimerization interface [polypeptide binding]; other site 150340010781 substrate binding pocket [chemical binding]; other site 150340010782 outer membrane protein A; Reviewed; Region: PRK10808 150340010783 Surface antigen; Region: Surface_Ag_2; cl01155 150340010784 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340010785 ligand binding site [chemical binding]; other site 150340010786 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 150340010787 A bacterial subgroup of the Peptidase M14-like domain of Nna-1 (Nervous system Nuclear protein induced by Axotomy), also known as ATP/GTP binding protein (AGTPBP-1) and cytosolic carboxypeptidase (CCP)-like proteins. The Peptidase M14 family of...; Region: M14_Nna1_like_1; cd06234 150340010788 putative active site [active] 150340010789 Zn-binding site [ion binding]; other site 150340010790 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 150340010791 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 150340010792 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 150340010793 Protein of unknown function (DUF535); Region: DUF535; cl01128 150340010794 Surface antigen; Region: Surface_Ag_2; cl01155 150340010795 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 150340010796 transcriptional regulator protein; Region: phnR; TIGR03337 150340010797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340010798 DNA-binding site [nucleotide binding]; DNA binding site 150340010799 UTRA domain; Region: UTRA; cl01230 150340010800 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 150340010801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340010802 dimer interface [polypeptide binding]; other site 150340010803 conserved gate region; other site 150340010804 putative PBP binding loops; other site 150340010805 ABC-ATPase subunit interface; other site 150340010806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340010807 dimer interface [polypeptide binding]; other site 150340010808 conserved gate region; other site 150340010809 putative PBP binding loops; other site 150340010810 ABC-ATPase subunit interface; other site 150340010811 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 150340010812 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340010813 Walker A/P-loop; other site 150340010814 ATP binding site [chemical binding]; other site 150340010815 Q-loop/lid; other site 150340010816 ABC transporter signature motif; other site 150340010817 Walker B; other site 150340010818 D-loop; other site 150340010819 H-loop/switch region; other site 150340010820 TOBE domain; Region: TOBE_2; cl01440 150340010821 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 150340010822 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340010823 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 150340010824 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 150340010825 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 150340010826 catalytic residue [active] 150340010827 4-aminobutyrate aminotransferase; Provisional; Region: PRK06082 150340010828 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 150340010829 inhibitor-cofactor binding pocket; inhibition site 150340010830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340010831 catalytic residue [active] 150340010832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 150340010833 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 150340010834 Transcriptional regulators [Transcription]; Region: PurR; COG1609 150340010835 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 150340010836 DNA binding site [nucleotide binding] 150340010837 domain linker motif; other site 150340010838 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 150340010839 putative ligand binding site [chemical binding]; other site 150340010840 putative dimerization interface [polypeptide binding]; other site 150340010841 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 150340010842 active site 150340010843 phosphorylation site [posttranslational modification] 150340010844 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 150340010845 P-loop; other site 150340010846 active site 150340010847 phosphorylation site [posttranslational modification] 150340010848 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 150340010849 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 150340010850 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 150340010851 active site 150340010852 catalytic residues [active] 150340010853 PA_VapT_like: Protease-associated domain containing proteins like VapT from Vibrio metschnikovii strain RH530. This group contains various PA domain-containing proteins similar to V. metschnikovii VapT, including the serine alkaline protease SapSh from...; Region: PA_VapT_like; cd04817 150340010854 PA/subtilisin-like domain interface [polypeptide binding]; other site 150340010855 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 150340010856 catalytic residues [active] 150340010857 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 150340010858 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 150340010859 active site 150340010860 catalytic triad [active] 150340010861 oxyanion hole [active] 150340010862 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 150340010863 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 150340010864 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 150340010865 active site 150340010866 zinc binding site [ion binding]; other site 150340010867 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl01158 150340010868 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 150340010869 dimer interface [polypeptide binding]; other site 150340010870 ADP-ribose binding site [chemical binding]; other site 150340010871 active site 150340010872 nudix motif; other site 150340010873 metal binding site [ion binding]; metal-binding site 150340010874 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 150340010875 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 150340010876 motif II; other site 150340010877 transcriptional regulator; Provisional; Region: PRK10632 150340010878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010879 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340010880 putative effector binding pocket; other site 150340010881 dimerization interface [polypeptide binding]; other site 150340010882 Predicted transcriptional regulator [Transcription]; Region: COG2378 150340010883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010884 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 150340010885 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families...; Region: ZnMc; cl00064 150340010886 active site 150340010887 maltose O-acetyltransferase; Provisional; Region: PRK10092 150340010888 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 150340010889 active site 150340010890 substrate binding site [chemical binding]; other site 150340010891 trimer interface [polypeptide binding]; other site 150340010892 CoA binding site [chemical binding]; other site 150340010893 OsmC-like protein; Region: OsmC; cl00767 150340010894 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 150340010895 SelR domain; Region: SelR; cl00369 150340010896 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 150340010897 NADP binding site [chemical binding]; other site 150340010898 homodimer interface [polypeptide binding]; other site 150340010899 active site 150340010900 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 150340010901 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 150340010902 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 150340010903 DNA photolyase; Region: DNA_photolyase; pfam00875 150340010904 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 150340010905 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340010906 metal binding site [ion binding]; metal-binding site 150340010907 active site 150340010908 I-site; other site 150340010909 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 150340010910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 150340010911 Domain of unknown function (DUF955); Region: DUF955; cl01076 150340010912 Protein of unknown function (DUF3612); Region: DUF3612; pfam12268 150340010913 CHASE domain; Region: CHASE; cl01369 150340010914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340010915 metal binding site [ion binding]; metal-binding site 150340010916 active site 150340010917 I-site; other site 150340010918 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 150340010919 Domain of unknown function (DUF3541); Region: DUF3541; pfam12060 150340010920 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 150340010921 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 150340010922 Nucleoside recognition; Region: Gate; cl00486 150340010923 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 150340010924 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 150340010925 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 150340010926 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 150340010927 substrate binding site [chemical binding]; other site 150340010928 tetramer interface [polypeptide binding]; other site 150340010929 catalytic residue [active] 150340010930 RnfE family; Region: NQR2_RnfD_RnfE; cl00779 150340010931 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 150340010932 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 150340010933 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 150340010934 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 150340010935 Predicted dehydrogenase [General function prediction only]; Region: COG0579 150340010936 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340010937 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 150340010938 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 150340010939 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 150340010940 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 150340010941 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340010942 metal binding site [ion binding]; metal-binding site 150340010943 active site 150340010944 I-site; other site 150340010945 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 150340010946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340010947 active site 150340010948 phosphorylation site [posttranslational modification] 150340010949 intermolecular recognition site; other site 150340010950 dimerization interface [polypeptide binding]; other site 150340010951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340010952 Walker A motif; other site 150340010953 ATP binding site [chemical binding]; other site 150340010954 Walker B motif; other site 150340010955 arginine finger; other site 150340010956 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340010957 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 150340010958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 150340010959 putative active site [active] 150340010960 heme pocket [chemical binding]; other site 150340010961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340010962 dimer interface [polypeptide binding]; other site 150340010963 phosphorylation site [posttranslational modification] 150340010964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340010965 ATP binding site [chemical binding]; other site 150340010966 Mg2+ binding site [ion binding]; other site 150340010967 G-X-G motif; other site 150340010968 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 150340010969 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 150340010970 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 150340010971 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 150340010972 Protein with unknown function (DUF469); Region: DUF469; cl01237 150340010973 Cupin domain; Region: Cupin_2; cl09118 150340010974 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340010975 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340010976 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 150340010977 dimerization interface [polypeptide binding]; other site 150340010978 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 150340010979 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 150340010980 Protein of unknown function (DUF785); Region: DUF785; cl01682 150340010981 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 150340010982 arginine decarboxylase; Provisional; Region: PRK05354 150340010983 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 150340010984 dimer interface [polypeptide binding]; other site 150340010985 active site 150340010986 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 150340010987 catalytic residues [active] 150340010988 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 150340010989 Arginase family; Region: Arginase; cl00306 150340010990 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 150340010991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340010992 putative substrate translocation pore; other site 150340010993 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 150340010994 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 150340010995 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 150340010996 trimer interface [polypeptide binding]; other site 150340010997 eyelet of channel; other site 150340010998 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 150340010999 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 150340011000 ABC-ATPase subunit interface; other site 150340011001 dimer interface [polypeptide binding]; other site 150340011002 putative PBP binding regions; other site 150340011003 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 150340011004 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 150340011005 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 150340011006 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 150340011007 metal binding site [ion binding]; metal-binding site 150340011008 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 150340011009 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670 150340011010 Predicted periplasmic protein (DUF2271); Region: DUF2271; cl01469 150340011011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 150340011012 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 150340011013 Gram-negative bacterial tonB protein; Region: TonB; cl10048 150340011014 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 150340011015 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 150340011016 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 150340011017 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 150340011018 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 150340011019 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 150340011020 N-terminal plug; other site 150340011021 ligand-binding site [chemical binding]; other site 150340011022 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340011023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340011024 dimer interface [polypeptide binding]; other site 150340011025 phosphorylation site [posttranslational modification] 150340011026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340011027 ATP binding site [chemical binding]; other site 150340011028 Mg2+ binding site [ion binding]; other site 150340011029 G-X-G motif; other site 150340011030 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 150340011031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340011032 active site 150340011033 phosphorylation site [posttranslational modification] 150340011034 intermolecular recognition site; other site 150340011035 dimerization interface [polypeptide binding]; other site 150340011036 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340011037 DNA binding site [nucleotide binding] 150340011038 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 150340011039 LDH/MDH dimer interface [polypeptide binding]; other site 150340011040 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 150340011041 NAD(P) binding site [chemical binding]; other site 150340011042 substrate binding site [chemical binding]; other site 150340011043 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 150340011044 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 150340011045 putative active site [active] 150340011046 catalytic site [active] 150340011047 putative metal binding site [ion binding]; other site 150340011048 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 150340011049 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 150340011050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340011051 Protein of unknown function (DUF2810); Region: DUF2810; cl08159 150340011052 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 150340011053 Protein of unknown function (DUF358); Region: DUF358; cl00827 150340011054 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 150340011055 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 150340011056 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 150340011057 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 150340011058 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 150340011059 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 150340011060 dimer interface [polypeptide binding]; other site 150340011061 substrate binding site [chemical binding]; other site 150340011062 ATP binding site [chemical binding]; other site 150340011063 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 150340011064 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 150340011065 Walker A/P-loop; other site 150340011066 ATP binding site [chemical binding]; other site 150340011067 Q-loop/lid; other site 150340011068 ABC transporter signature motif; other site 150340011069 Walker B; other site 150340011070 D-loop; other site 150340011071 H-loop/switch region; other site 150340011072 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 150340011073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340011074 dimer interface [polypeptide binding]; other site 150340011075 conserved gate region; other site 150340011076 ABC-ATPase subunit interface; other site 150340011077 NMT1/THI5 like; Region: NMT1; pfam09084 150340011078 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 150340011079 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 150340011080 substrate binding site [chemical binding]; other site 150340011081 multimerization interface [polypeptide binding]; other site 150340011082 ATP binding site [chemical binding]; other site 150340011083 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 150340011084 thiamine phosphate binding site [chemical binding]; other site 150340011085 active site 150340011086 pyrophosphate binding site [ion binding]; other site 150340011087 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 150340011088 active site 150340011089 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 150340011090 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 150340011091 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 150340011092 molybdopterin cofactor binding site [chemical binding]; other site 150340011093 substrate binding site [chemical binding]; other site 150340011094 The MopB_CT_DMSOR-like CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-like; cd02777 150340011095 molybdopterin cofactor binding site; other site 150340011096 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 150340011097 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl09485 150340011098 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 150340011099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340011100 short chain dehydrogenase; Provisional; Region: PRK06123 150340011101 classical (c) SDRs; Region: SDR_c; cd05233 150340011102 NAD(P) binding site [chemical binding]; other site 150340011103 active site 150340011104 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 150340011105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340011106 Coenzyme A binding pocket [chemical binding]; other site 150340011107 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 150340011108 active site 150340011109 motif I; other site 150340011110 motif II; other site 150340011111 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 150340011112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340011113 Coenzyme A binding pocket [chemical binding]; other site 150340011114 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 150340011115 EamA-like transporter family; Region: EamA; cl01037 150340011116 EamA-like transporter family; Region: EamA; cl01037 150340011117 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 150340011118 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340011119 DNA-binding site [nucleotide binding]; DNA binding site 150340011120 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 150340011121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340011122 homodimer interface [polypeptide binding]; other site 150340011123 catalytic residue [active] 150340011124 Glycerate kinase family; Region: Gly_kinase; cl00841 150340011125 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 150340011126 GntP family permease; Region: GntP_permease; cl15264 150340011127 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 150340011128 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 150340011129 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340011130 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 150340011131 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 150340011132 active site 150340011133 Zn binding site [ion binding]; other site 150340011134 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 150340011135 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 150340011136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 150340011137 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 150340011138 active site 150340011139 metal binding site [ion binding]; metal-binding site 150340011140 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340011141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011142 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340011143 dimerization interface [polypeptide binding]; other site 150340011144 Uncharacterized conserved protein [Function unknown]; Region: COG5361 150340011145 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 150340011146 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 150340011147 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340011148 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011149 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340011150 dimerization interface [polypeptide binding]; other site 150340011151 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 150340011152 dimer interface [polypeptide binding]; other site 150340011153 metal binding site [ion binding]; metal-binding site 150340011154 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 150340011155 putative ADP-ribose binding site [chemical binding]; other site 150340011156 putative active site [active] 150340011157 alpha-glucosidase; Provisional; Region: PRK10137 150340011158 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 150340011159 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 150340011160 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 150340011161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340011162 Major Facilitator Superfamily; Region: MFS_1; pfam07690 150340011163 putative substrate translocation pore; other site 150340011164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340011165 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 150340011166 Outer membrane efflux protein; Region: OEP; pfam02321 150340011167 Surface antigen; Region: Surface_Ag_2; cl01155 150340011168 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 150340011169 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 150340011170 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 150340011171 Cupin domain; Region: Cupin_2; cl09118 150340011172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 150340011173 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 150340011174 Chitin binding domain; Region: Chitin_bind_3; cl03871 150340011175 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 150340011176 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 150340011177 chitin/cellulose binding site [chemical binding]; other site 150340011178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011179 LysE type translocator; Region: LysE; cl00565 150340011180 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 150340011181 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 150340011182 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 150340011183 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 150340011184 FAD binding pocket [chemical binding]; other site 150340011185 FAD binding motif [chemical binding]; other site 150340011186 phosphate binding motif [ion binding]; other site 150340011187 NAD binding pocket [chemical binding]; other site 150340011188 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 150340011189 Sodium:solute symporter family; Region: SSF; cl00456 150340011190 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 150340011191 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 150340011192 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 150340011193 active site 150340011194 intersubunit interface [polypeptide binding]; other site 150340011195 catalytic residue [active] 150340011196 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 150340011197 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 150340011198 substrate binding site [chemical binding]; other site 150340011199 ATP binding site [chemical binding]; other site 150340011200 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 150340011201 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 150340011202 hypothetical protein; Provisional; Region: PRK09273 150340011203 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 150340011204 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 150340011205 Cupin domain; Region: Cupin_2; cl09118 150340011206 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 150340011207 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 150340011208 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 150340011209 NADP binding site [chemical binding]; other site 150340011210 homodimer interface [polypeptide binding]; other site 150340011211 active site 150340011212 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 150340011213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011214 Bacterial transcriptional regulator; Region: IclR; pfam01614 150340011215 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 150340011216 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 150340011217 ligand binding site [chemical binding]; other site 150340011218 flexible hinge region; other site 150340011219 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain...; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc; cd04587 150340011220 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 150340011221 metal binding triad; other site 150340011222 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 150340011223 active site 150340011224 substrate binding site [chemical binding]; other site 150340011225 catalytic site [active] 150340011226 LysR family transcriptional regulator; Provisional; Region: PRK14997 150340011227 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011228 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340011229 dimerization interface [polypeptide binding]; other site 150340011230 N-acetyltransferase; Region: Acetyltransf_2; cl00949 150340011231 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 150340011232 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 150340011233 substrate binding site [chemical binding]; other site 150340011234 catalytic Zn binding site [ion binding]; other site 150340011235 NAD binding site [chemical binding]; other site 150340011236 structural Zn binding site [ion binding]; other site 150340011237 dimer interface [polypeptide binding]; other site 150340011238 Predicted esterase [General function prediction only]; Region: COG0627 150340011239 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 150340011240 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 150340011241 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340011242 metal binding site [ion binding]; metal-binding site 150340011243 active site 150340011244 I-site; other site 150340011245 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 150340011246 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 150340011247 active site 150340011248 motif I; other site 150340011249 motif II; other site 150340011250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 150340011251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340011252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011253 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340011254 putative effector binding pocket; other site 150340011255 dimerization interface [polypeptide binding]; other site 150340011256 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 150340011257 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 150340011258 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 150340011259 catalytic residues [active] 150340011260 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 150340011261 active site 150340011262 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 150340011263 MatE; Region: MatE; cl10513 150340011264 MatE; Region: MatE; cl10513 150340011265 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340011266 metal binding site [ion binding]; metal-binding site 150340011267 active site 150340011268 I-site; other site 150340011269 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 150340011270 Protein of unknown function (DUF2850); Region: DUF2850; pfam11012 150340011271 Chitinase N-terminus domain. Chitinases hydrolyze the abundant natural biopolymer chitin, producing smaller chito-oligosaccharides. Chitin consists of multiple N-acetyl-D-glucosamine (NAG) residues connected via beta-1,4-glycosidic linkages and is an...; Region: Chitinase_N_term; cd02848 150340011272 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 150340011273 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548 150340011274 active site 150340011275 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 150340011276 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 150340011277 chitin/cellulose binding site [chemical binding]; other site 150340011278 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 150340011279 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 150340011280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 150340011281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 150340011282 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 150340011283 Acyltransferase family; Region: Acyl_transf_3; pfam01757 150340011284 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340011285 transmembrane helices; other site 150340011286 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 150340011287 Uncharacterized conserved protein [Function unknown]; Region: COG1284 150340011288 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 150340011289 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 150340011290 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 150340011291 DNA binding site [nucleotide binding] 150340011292 active site 150340011293 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 150340011294 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 150340011295 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340011296 AlkA N-terminal domain; Region: AlkA_N; cl05528 150340011297 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 150340011298 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 150340011299 minor groove reading motif; other site 150340011300 helix-hairpin-helix signature motif; other site 150340011301 active site 150340011302 DoxX; Region: DoxX; cl00976 150340011303 Pirin-related protein [General function prediction only]; Region: COG1741 150340011304 Cupin domain; Region: Cupin_2; cl09118 150340011305 transcriptional regulator HdfR; Provisional; Region: PRK03601 150340011306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340011308 Protein of unknown function, DUF; Region: DUF413; cl10479 150340011309 Protein of unknown function (DUF3081); Region: DUF3081; pfam11280 150340011310 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 150340011311 active site 150340011312 trimer interface [polypeptide binding]; other site 150340011313 allosteric site; other site 150340011314 active site lid [active] 150340011315 hexamer (dimer of trimers) interface [polypeptide binding]; other site 150340011316 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 150340011317 Predicted transcriptional regulators [Transcription]; Region: COG1725 150340011318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 150340011319 DNA-binding site [nucleotide binding]; DNA binding site 150340011320 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 150340011321 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 150340011322 Walker A/P-loop; other site 150340011323 ATP binding site [chemical binding]; other site 150340011324 Q-loop/lid; other site 150340011325 ABC transporter signature motif; other site 150340011326 Walker B; other site 150340011327 D-loop; other site 150340011328 H-loop/switch region; other site 150340011329 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 150340011330 Protein of unknown function, DUF393; Region: DUF393; cl01136 150340011331 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 150340011332 Cache domain; Region: Cache_2; cl07034 150340011333 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340011334 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340011335 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 150340011336 substrate binding site [chemical binding]; other site 150340011337 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 150340011338 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 150340011339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340011340 active site 150340011341 phosphorylation site [posttranslational modification] 150340011342 intermolecular recognition site; other site 150340011343 dimerization interface [polypeptide binding]; other site 150340011344 LytTr DNA-binding domain; Region: LytTR; cl04498 150340011345 Histidine kinase; Region: His_kinase; pfam06580 150340011346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340011347 ATP binding site [chemical binding]; other site 150340011348 Mg2+ binding site [ion binding]; other site 150340011349 G-X-G motif; other site 150340011350 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 150340011351 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 150340011352 FtsX-like permease family; Region: FtsX; pfam02687 150340011353 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 150340011354 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 150340011355 Walker A/P-loop; other site 150340011356 ATP binding site [chemical binding]; other site 150340011357 Q-loop/lid; other site 150340011358 ABC transporter signature motif; other site 150340011359 Walker B; other site 150340011360 D-loop; other site 150340011361 H-loop/switch region; other site 150340011362 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 150340011363 Domain of unknown function DUF28; Region: DUF28; cl00361 150340011364 Protein of unknown function (DUF3283); Region: DUF3283; pfam11686 150340011365 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 150340011366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340011367 dimer interface [polypeptide binding]; other site 150340011368 phosphorylation site [posttranslational modification] 150340011369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340011370 ATP binding site [chemical binding]; other site 150340011371 Mg2+ binding site [ion binding]; other site 150340011372 G-X-G motif; other site 150340011373 Response regulator receiver domain; Region: Response_reg; pfam00072 150340011374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340011375 active site 150340011376 phosphorylation site [posttranslational modification] 150340011377 intermolecular recognition site; other site 150340011378 dimerization interface [polypeptide binding]; other site 150340011379 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 150340011380 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 150340011381 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 150340011382 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 150340011383 dimerization interface [polypeptide binding]; other site 150340011384 active site 150340011385 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 150340011386 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340011387 Walker A/P-loop; other site 150340011388 ATP binding site [chemical binding]; other site 150340011389 Q-loop/lid; other site 150340011390 ABC transporter signature motif; other site 150340011391 Walker B; other site 150340011392 D-loop; other site 150340011393 H-loop/switch region; other site 150340011394 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 150340011395 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 150340011396 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340011397 Walker A/P-loop; other site 150340011398 ATP binding site [chemical binding]; other site 150340011399 Q-loop/lid; other site 150340011400 ABC transporter signature motif; other site 150340011401 Walker B; other site 150340011402 D-loop; other site 150340011403 H-loop/switch region; other site 150340011404 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 150340011405 Protein of unknown function (DUF3346); Region: DUF3346; pfam11826 150340011406 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 150340011407 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 150340011408 P-loop; other site 150340011409 Magnesium ion binding site [ion binding]; other site 150340011410 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 150340011411 Magnesium ion binding site [ion binding]; other site 150340011412 plasmid-partitioning protein; Provisional; Region: PRK13698 150340011413 ParB-like nuclease domain; Region: ParBc; cl02129 150340011414 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 150340011415 Putative ATPase (DUF699); Region: DUF699; pfam05127 150340011416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340011417 Coenzyme A binding pocket [chemical binding]; other site 150340011418 Protein of unknown function (DUF342); Region: DUF342; pfam03961 150340011419 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 150340011420 trimer interface [polypeptide binding]; other site 150340011421 active site 150340011422 substrate binding site [chemical binding]; other site 150340011423 CoA binding site [chemical binding]; other site 150340011424 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340011425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011426 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340011427 dimerization interface [polypeptide binding]; other site 150340011428 putative effector binding pocket; other site 150340011429 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 150340011430 trimer interface [polypeptide binding]; other site 150340011431 eyelet of channel; other site 150340011432 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 150340011433 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 150340011434 active site turn [active] 150340011435 phosphorylation site [posttranslational modification] 150340011436 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340011437 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 150340011438 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 150340011439 putative active site [active] 150340011440 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 150340011441 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 150340011442 putative active site [active] 150340011443 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A (MpaA) and related proteins. MpaA is a member of the M14 family of metallocarboxypeptidases (MCPs), however it has an exceptional type of activity, it hydrolyzes the gamma-D-...; Region: M14_MpaA_like; cd06904 150340011444 putative active site [active] 150340011445 Zn-binding site [ion binding]; other site 150340011446 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 150340011447 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 150340011448 peptide binding site [polypeptide binding]; other site 150340011449 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 150340011450 Mechanosensitive ion channel; Region: MS_channel; pfam00924 150340011451 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 150340011452 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 150340011453 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 150340011454 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 150340011455 Walker A/P-loop; other site 150340011456 ATP binding site [chemical binding]; other site 150340011457 Q-loop/lid; other site 150340011458 ABC transporter signature motif; other site 150340011459 Walker B; other site 150340011460 D-loop; other site 150340011461 H-loop/switch region; other site 150340011462 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340011463 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340011464 metal binding site [ion binding]; metal-binding site 150340011465 active site 150340011466 I-site; other site 150340011467 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340011468 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 150340011469 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 150340011470 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 150340011471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340011472 active site 150340011473 phosphorylation site [posttranslational modification] 150340011474 intermolecular recognition site; other site 150340011475 dimerization interface [polypeptide binding]; other site 150340011476 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340011477 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 150340011478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 150340011479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340011480 ATP binding site [chemical binding]; other site 150340011481 Mg2+ binding site [ion binding]; other site 150340011482 G-X-G motif; other site 150340011483 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 150340011484 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 150340011485 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 150340011486 PAS fold; Region: PAS_4; pfam08448 150340011487 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 150340011488 DNA binding residues [nucleotide binding] 150340011489 dimerization interface [polypeptide binding]; other site 150340011490 transcriptional activator RhaS; Provisional; Region: PRK13503 150340011491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340011492 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340011493 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 150340011494 Proline dehydrogenase; Region: Pro_dh; cl03282 150340011495 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 150340011496 Glutamate binding site [chemical binding]; other site 150340011497 NAD binding site [chemical binding]; other site 150340011498 catalytic residues [active] 150340011499 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 150340011500 NAD(P) binding site [chemical binding]; other site 150340011501 catalytic residues [active] 150340011502 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 150340011503 Sodium:solute symporter family; Region: SSF; cl00456 150340011504 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 150340011505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340011506 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 150340011507 RNA/DNA binding site [nucleotide binding]; other site 150340011508 RRM dimerization site [polypeptide binding]; other site 150340011509 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 150340011510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340011511 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 150340011512 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011513 Protein of unknown function (DUF445); Region: DUF445; pfam04286 150340011514 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 150340011515 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 150340011516 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 150340011517 Walker A/P-loop; other site 150340011518 ATP binding site [chemical binding]; other site 150340011519 Q-loop/lid; other site 150340011520 ABC transporter signature motif; other site 150340011521 Walker B; other site 150340011522 D-loop; other site 150340011523 H-loop/switch region; other site 150340011524 Amidinotransferase; Region: Amidinotransf; cl12043 150340011525 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 150340011526 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 150340011527 Cupin domain; Region: Cupin_2; cl09118 150340011528 Domain of unknown function (DUF369); Region: DUF369; cl00950 150340011529 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 150340011530 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 150340011531 Cupin domain; Region: Cupin_2; cl09118 150340011532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 150340011533 MOSC domain; Region: MOSC; pfam03473 150340011534 3-alpha domain; Region: 3-alpha; pfam03475 150340011535 Cupin domain; Region: Cupin_2; cl09118 150340011536 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340011537 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340011538 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 150340011539 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 150340011540 NADP binding site [chemical binding]; other site 150340011541 dimer interface [polypeptide binding]; other site 150340011542 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 150340011543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 150340011544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 150340011545 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 150340011546 conserved cys residue [active] 150340011547 transcriptional regulator; Provisional; Region: PRK10632 150340011548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011549 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340011550 putative effector binding pocket; other site 150340011551 dimerization interface [polypeptide binding]; other site 150340011552 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 150340011553 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 150340011554 active site 150340011555 metal binding site [ion binding]; metal-binding site 150340011556 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 150340011557 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the...; Region: AhpF_NTD_N; cd02974 150340011558 catalytic residue [active] 150340011559 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 150340011560 catalytic residues [active] 150340011561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340011562 peroxiredoxin; Region: AhpC; TIGR03137 150340011563 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 150340011564 dimer interface [polypeptide binding]; other site 150340011565 decamer (pentamer of dimers) interface [polypeptide binding]; other site 150340011566 catalytic triad [active] 150340011567 peroxidatic and resolving cysteines [active] 150340011568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011569 OsmC-like protein; Region: OsmC; cl00767 150340011570 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 150340011571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340011572 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 150340011573 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 150340011574 FtsX-like permease family; Region: FtsX; pfam02687 150340011575 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 150340011576 FtsX-like permease family; Region: FtsX; pfam02687 150340011577 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 150340011578 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 150340011579 Walker A/P-loop; other site 150340011580 ATP binding site [chemical binding]; other site 150340011581 Q-loop/lid; other site 150340011582 ABC transporter signature motif; other site 150340011583 Walker B; other site 150340011584 D-loop; other site 150340011585 H-loop/switch region; other site 150340011586 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 150340011587 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 150340011588 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 150340011589 Ligand binding site [chemical binding]; other site 150340011590 Putative Catalytic site [active] 150340011591 DXD motif; other site 150340011592 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 150340011593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 150340011594 Peptidase family U32; Region: Peptidase_U32; cl03113 150340011595 Peptidase family U32; Region: Peptidase_U32; cl03113 150340011596 Domain of unknown function DUF302; Region: DUF302; cl01364 150340011597 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340011598 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 150340011599 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 150340011600 active site turn [active] 150340011601 phosphorylation site [posttranslational modification] 150340011602 osmolarity response regulator; Provisional; Region: ompR; PRK09468 150340011603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340011604 active site 150340011605 phosphorylation site [posttranslational modification] 150340011606 intermolecular recognition site; other site 150340011607 dimerization interface [polypeptide binding]; other site 150340011608 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340011609 DNA binding site [nucleotide binding] 150340011610 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 150340011611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340011612 ATP binding site [chemical binding]; other site 150340011613 Mg2+ binding site [ion binding]; other site 150340011614 G-X-G motif; other site 150340011615 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 150340011616 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340011617 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 150340011618 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 150340011619 dimer interface [polypeptide binding]; other site 150340011620 active site 150340011621 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 150340011622 catalytic residues [active] 150340011623 substrate binding site [chemical binding]; other site 150340011624 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 150340011625 IucA / IucC family; Region: IucA_IucC; pfam04183 150340011626 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 150340011627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340011628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 150340011629 putative substrate translocation pore; other site 150340011630 IucA / IucC family; Region: IucA_IucC; pfam04183 150340011631 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 150340011632 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 150340011633 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 150340011634 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 150340011635 N-terminal plug; other site 150340011636 ligand-binding site [chemical binding]; other site 150340011637 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 150340011638 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 150340011639 N-terminal plug; other site 150340011640 ligand-binding site [chemical binding]; other site 150340011641 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 150340011642 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 150340011643 siderophore binding site; other site 150340011644 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 150340011645 ABC-ATPase subunit interface; other site 150340011646 dimer interface [polypeptide binding]; other site 150340011647 putative PBP binding regions; other site 150340011648 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 150340011649 ABC-ATPase subunit interface; other site 150340011650 dimer interface [polypeptide binding]; other site 150340011651 putative PBP binding regions; other site 150340011652 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 150340011653 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 150340011654 Walker A/P-loop; other site 150340011655 ATP binding site [chemical binding]; other site 150340011656 Q-loop/lid; other site 150340011657 ABC transporter signature motif; other site 150340011658 Walker B; other site 150340011659 D-loop; other site 150340011660 H-loop/switch region; other site 150340011661 Cache domain; Region: Cache_1; pfam02743 150340011662 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 150340011663 dimerization interface [polypeptide binding]; other site 150340011664 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340011665 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340011666 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 150340011667 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 150340011668 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 150340011669 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 150340011670 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 150340011671 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 150340011672 Peptidase family M23; Region: Peptidase_M23; pfam01551 150340011673 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 150340011674 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 150340011675 putative lipid binding site [chemical binding]; other site 150340011676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340011677 putative substrate translocation pore; other site 150340011678 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 150340011679 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 150340011680 catalytic residues [active] 150340011681 catalytic nucleophile [active] 150340011682 Presynaptic Site I dimer interface [polypeptide binding]; other site 150340011683 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 150340011684 Synaptic Flat tetramer interface [polypeptide binding]; other site 150340011685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011686 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 150340011687 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 150340011688 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 150340011689 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel beta-...; Region: Maltoporin-like; cd01346 150340011690 trimer interface; other site 150340011691 sugar binding site [chemical binding]; other site 150340011692 Maltose operon periplasmic protein precursor (MalM); Region: MalM; cl11647 150340011693 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 150340011694 maltodextrin glucosidase; Provisional; Region: PRK10785 150340011695 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 150340011696 Endonuclease I; Region: Endonuclease_1; cl01003 150340011697 Bacterial pullanase-associated domain; Region: PUD; pfam03714 150340011698 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 150340011699 Pullulanase domain N-terminus. Pullulanase (AKA dextrinase; alpha-dextrin endo-1,6-alpha glucosidase) is an enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-...; Region: Pullulanase_N_term; cd02860 150340011700 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 150340011701 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 150340011702 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 150340011703 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 150340011704 Sel1 repeat; Region: Sel1; cl02723 150340011705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 150340011706 ornithine decarboxylase; Provisional; Region: PRK13578 150340011707 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and...; Region: Orn_deC_like; cd00615 150340011708 homodimer interface [polypeptide binding]; other site 150340011709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340011710 catalytic residue [active] 150340011711 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 150340011712 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 150340011713 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 150340011714 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 150340011715 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 150340011716 pyridoxal binding site [chemical binding]; other site 150340011717 dimer interface [polypeptide binding]; other site 150340011718 ATP binding site [chemical binding]; other site 150340011719 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 150340011720 GTPase RsgA; Reviewed; Region: PRK01889 150340011721 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 150340011722 GTPase/OB domain interface [polypeptide binding]; other site 150340011723 GTPase/Zn-binding domain interface [polypeptide binding]; other site 150340011724 GTP/Mg2+ binding site [chemical binding]; other site 150340011725 G4 box; other site 150340011726 G5 box; other site 150340011727 G1 box; other site 150340011728 Switch I region; other site 150340011729 G2 box; other site 150340011730 G3 box; other site 150340011731 Switch II region; other site 150340011732 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cl00164 150340011733 active site turn [active] 150340011734 phosphorylation site [posttranslational modification] 150340011735 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 150340011736 Cu(I) binding site [ion binding]; other site 150340011737 Domain of unknown function (DUF368); Region: DUF368; cl00893 150340011738 transcriptional regulator MalT; Provisional; Region: PRK04841 150340011739 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 150340011740 DNA binding residues [nucleotide binding] 150340011741 dimerization interface [polypeptide binding]; other site 150340011742 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 150340011743 homodimer interface [polypeptide binding]; other site 150340011744 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 150340011745 active site pocket [active] 150340011746 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 150340011747 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 150340011748 glycogen branching enzyme; Provisional; Region: PRK05402 150340011749 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 150340011750 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 150340011751 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 150340011752 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 150340011753 Transglycosylase; Region: Transgly; cl07896 150340011754 alpha-amylase; Reviewed; Region: malS; PRK09505 150340011755 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 150340011756 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 150340011757 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a...; Region: DsbA_Com1_like; cd03023 150340011758 catalytic residues [active] 150340011759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 150340011760 Nucleoside recognition; Region: Gate; cl00486 150340011761 Nucleoside recognition; Region: Gate; cl00486 150340011762 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 150340011763 hypothetical protein; Provisional; Region: PRK07338 150340011764 metal binding site [ion binding]; metal-binding site 150340011765 dimer interface [polypeptide binding]; other site 150340011766 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 150340011767 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 150340011768 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 150340011769 tyrosine kinase; Provisional; Region: PRK11519 150340011770 Chain length determinant protein; Region: Wzz; cl01623 150340011771 Chain length determinant protein; Region: Wzz; cl01623 150340011772 Chain length determinant protein; Region: Wzz; cl01623 150340011773 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 150340011774 P loop; other site 150340011775 Nucleotide binding site [chemical binding]; other site 150340011776 DTAP/Switch II; other site 150340011777 Switch I; other site 150340011778 Low molecular weight phosphatase family; Region: LMWPc; cd00115 150340011779 polysaccharide export protein Wza; Provisional; Region: PRK15078 150340011780 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 150340011781 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH...; Region: NfsA_FRP; cd02146 150340011782 dimer interface [polypeptide binding]; other site 150340011783 FMN binding site [chemical binding]; other site 150340011784 NADPH bind site [chemical binding]; other site 150340011785 MarC family integral membrane protein; Region: MarC; cl00919 150340011786 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 150340011787 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 150340011788 active site 150340011789 nucleophile elbow; other site 150340011790 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 150340011791 Chitin binding domain; Region: Chitin_bind_3; cl03871 150340011792 Fasciclin domain; Region: Fasciclin; cl02663 150340011793 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 150340011794 DNA photolyase; Region: DNA_photolyase; pfam00875 150340011795 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 150340011796 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 150340011797 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 150340011798 active site residue [active] 150340011799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340011800 Coenzyme A binding pocket [chemical binding]; other site 150340011801 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 150340011802 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 150340011803 Beta-lactamase; Region: Beta-lactamase; cl01009 150340011804 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 150340011805 trehalose synthase; Region: treS_nterm; TIGR02456 150340011806 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 150340011807 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 150340011808 putative ligand binding site [chemical binding]; other site 150340011809 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340011810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340011811 Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370 150340011812 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 150340011813 dimer interface [polypeptide binding]; other site 150340011814 FMN binding site [chemical binding]; other site 150340011815 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 150340011816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340011817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011818 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340011819 putative effector binding pocket; other site 150340011820 dimerization interface [polypeptide binding]; other site 150340011821 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 150340011822 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 150340011823 active site 150340011824 ferredoxin-NADP reductase; Provisional; Region: PRK10926 150340011825 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 150340011826 FAD binding pocket [chemical binding]; other site 150340011827 FAD binding motif [chemical binding]; other site 150340011828 phosphate binding motif [ion binding]; other site 150340011829 beta-alpha-beta structure motif; other site 150340011830 NAD binding pocket [chemical binding]; other site 150340011831 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 150340011832 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 150340011833 Domain of unknown function DUF20; Region: UPF0118; cl00465 150340011834 Ion channel; Region: Ion_trans_2; cl11596 150340011835 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 150340011836 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 150340011837 NodT family; Region: outer_NodT; TIGR01845 150340011838 Outer membrane efflux protein; Region: OEP; pfam02321 150340011839 Outer membrane efflux protein; Region: OEP; pfam02321 150340011840 Fusaric acid resistance protein family; Region: FUSC; pfam04632 150340011841 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 150340011842 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011843 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 150340011844 substrate binding pocket [chemical binding]; other site 150340011845 dimerization interface [polypeptide binding]; other site 150340011846 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 150340011847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340011848 putative substrate translocation pore; other site 150340011849 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340011850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340011851 Coenzyme A binding pocket [chemical binding]; other site 150340011852 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 150340011853 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 150340011854 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 150340011855 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 150340011856 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 150340011857 active site 150340011858 intersubunit interactions; other site 150340011859 catalytic residue [active] 150340011860 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 150340011861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 150340011862 pyruvate formate-lyase; Region: PFL2-3; TIGR01774 150340011863 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 150340011864 dimer interface [polypeptide binding]; other site 150340011865 active site 150340011866 glycine loop; other site 150340011867 Uncharacterized conserved protein [Function unknown]; Region: COG3268 150340011868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340011869 NAD(P) binding site [chemical binding]; other site 150340011870 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 150340011871 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 150340011872 putative NAD(P) binding site [chemical binding]; other site 150340011873 putative active site [active] 150340011874 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 150340011875 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 150340011876 DNA binding residues [nucleotide binding] 150340011877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 150340011878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 150340011879 HPP family; Region: HPP; pfam04982 150340011880 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 150340011881 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 150340011882 hypothetical protein; Validated; Region: PRK06778 150340011883 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340011884 ligand binding site [chemical binding]; other site 150340011885 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 150340011886 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 150340011887 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 150340011888 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 150340011889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 150340011890 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 150340011891 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 150340011892 Flagellar protein FliS; Region: FliS; cl00654 150340011893 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 150340011894 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 150340011895 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 150340011896 Thiamine pyrophosphokinase; Region: TPK; cl09135 150340011897 flagellin; Provisional; Region: PRK12802 150340011898 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 150340011899 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 150340011900 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 150340011901 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 150340011902 FHIPEP family; Region: FHIPEP; pfam00771 150340011903 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 150340011904 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 150340011905 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 150340011906 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 150340011907 FliP family; Region: FliP; cl00593 150340011908 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 150340011909 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 150340011910 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 150340011911 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340011912 ligand binding site [chemical binding]; other site 150340011913 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 150340011914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340011915 active site 150340011916 phosphorylation site [posttranslational modification] 150340011917 intermolecular recognition site; other site 150340011918 dimerization interface [polypeptide binding]; other site 150340011919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340011920 Walker A motif; other site 150340011921 ATP binding site [chemical binding]; other site 150340011922 Walker B motif; other site 150340011923 arginine finger; other site 150340011924 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 150340011925 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 150340011926 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 150340011927 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 150340011928 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 150340011929 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 150340011930 FliG C-terminal domain; Region: FliG_C; pfam01706 150340011931 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 150340011932 Flagellar assembly protein FliH; Region: FliH; pfam02108 150340011933 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 150340011934 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 150340011935 Walker A motif/ATP binding site; other site 150340011936 Walker B motif; other site 150340011937 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 150340011938 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cd00190 150340011939 cleavage site 150340011940 active site 150340011941 substrate binding sites [chemical binding]; other site 150340011942 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 150340011943 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011944 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340011945 dimerization interface [polypeptide binding]; other site 150340011946 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 150340011947 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 150340011948 putative hydrophobic ligand binding site [chemical binding]; other site 150340011949 putative hydrolase; Validated; Region: PRK09248 150340011950 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 150340011951 Cytochrome b562; Region: Cytochrom_B562; cl01546 150340011952 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 150340011953 putative metal binding site [ion binding]; other site 150340011954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340011955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340011956 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340011957 putative effector binding pocket; other site 150340011958 dimerization interface [polypeptide binding]; other site 150340011959 Spondin_N; Region: Spond_N; pfam06468 150340011960 Spondin_N; Region: Spond_N; pfam06468 150340011961 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 150340011962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340011963 active site 150340011964 phosphorylation site [posttranslational modification] 150340011965 intermolecular recognition site; other site 150340011966 dimerization interface [polypeptide binding]; other site 150340011967 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340011968 DNA binding site [nucleotide binding] 150340011969 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 150340011970 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 150340011971 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 150340011972 E-class dimer interface [polypeptide binding]; other site 150340011973 P-class dimer interface [polypeptide binding]; other site 150340011974 active site 150340011975 Cu2+ binding site [ion binding]; other site 150340011976 Zn2+ binding site [ion binding]; other site 150340011977 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 150340011978 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 150340011979 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 150340011980 catalytic residue [active] 150340011981 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 150340011982 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 150340011983 substrate binding pocket [chemical binding]; other site 150340011984 membrane-bound complex binding site; other site 150340011985 hinge residues; other site 150340011986 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340011987 metal binding site [ion binding]; metal-binding site 150340011988 active site 150340011989 I-site; other site 150340011990 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340011991 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 150340011992 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 150340011993 substrate-cofactor binding pocket; other site 150340011994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340011995 catalytic residue [active] 150340011996 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 150340011997 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 150340011998 NAD(P) binding site [chemical binding]; other site 150340011999 Spore Coat Protein U domain; Region: SCPU; cl02253 150340012000 Spore Coat Protein U domain; Region: SCPU; cl02253 150340012001 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 150340012002 putative fimbrial chaperone protein; Provisional; Region: PRK09918 150340012003 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 150340012004 Spore Coat Protein U domain; Region: SCPU; cl02253 150340012005 Spore Coat Protein U domain; Region: SCPU; cl02253 150340012006 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 150340012007 active site 150340012008 zinc binding site [ion binding]; other site 150340012009 mechanosensitive channel MscS; Provisional; Region: PRK10334 150340012010 Mechanosensitive ion channel; Region: MS_channel; pfam00924 150340012011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 150340012012 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 150340012013 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 150340012014 active site 150340012015 substrate binding site [chemical binding]; other site 150340012016 FMN binding site [chemical binding]; other site 150340012017 putative catalytic residues [active] 150340012018 L-lactate permease; Region: Lactate_perm; cl00701 150340012019 glycolate transporter; Provisional; Region: PRK09695 150340012020 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340012021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340012022 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340012023 putative effector binding pocket; other site 150340012024 dimerization interface [polypeptide binding]; other site 150340012025 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 150340012026 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 150340012027 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 150340012028 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340012029 Walker A/P-loop; other site 150340012030 ATP binding site [chemical binding]; other site 150340012031 Q-loop/lid; other site 150340012032 ABC transporter signature motif; other site 150340012033 Walker B; other site 150340012034 D-loop; other site 150340012035 H-loop/switch region; other site 150340012036 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 150340012037 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 150340012038 Walker A/P-loop; other site 150340012039 ATP binding site [chemical binding]; other site 150340012040 Q-loop/lid; other site 150340012041 ABC transporter signature motif; other site 150340012042 Walker B; other site 150340012043 D-loop; other site 150340012044 H-loop/switch region; other site 150340012045 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 150340012046 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 150340012047 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 150340012048 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340012049 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340012050 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340012051 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 150340012052 trimer interface [polypeptide binding]; other site 150340012053 eyelet of channel; other site 150340012054 Flagellar protein YcgR; Region: YcgR_2; pfam12945 150340012055 PilZ domain; Region: PilZ; cl01260 150340012056 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340012057 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 150340012058 putative acetyltransferase YhhY; Provisional; Region: PRK10140 150340012059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340012060 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 150340012061 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 150340012062 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 150340012063 4Fe-4S binding domain; Region: Fer4_5; pfam12801 150340012064 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 150340012065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340012066 Cobalt transport protein; Region: CbiQ; cl00463 150340012067 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 150340012068 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 150340012069 Walker A/P-loop; other site 150340012070 ATP binding site [chemical binding]; other site 150340012071 Q-loop/lid; other site 150340012072 ABC transporter signature motif; other site 150340012073 Walker B; other site 150340012074 D-loop; other site 150340012075 H-loop/switch region; other site 150340012076 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 150340012077 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 150340012078 Walker A/P-loop; other site 150340012079 ATP binding site [chemical binding]; other site 150340012080 Q-loop/lid; other site 150340012081 ABC transporter signature motif; other site 150340012082 Walker B; other site 150340012083 D-loop; other site 150340012084 H-loop/switch region; other site 150340012085 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 150340012086 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 150340012087 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 150340012088 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340012089 metal binding site [ion binding]; metal-binding site 150340012090 active site 150340012091 I-site; other site 150340012092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 150340012093 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 150340012094 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 150340012095 Protein of unknown function (DUF523); Region: DUF523; cl00733 150340012096 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 150340012097 transcriptional regulator MirA; Provisional; Region: PRK15043 150340012098 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 150340012099 DNA binding residues [nucleotide binding] 150340012100 DNA photolyase; Region: DNA_photolyase; pfam00875 150340012101 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 150340012102 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 150340012103 L,D-transpeptidase; Provisional; Region: PRK10260 150340012104 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 150340012105 putative peptidoglycan binding site; other site 150340012106 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 150340012107 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 150340012108 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 150340012109 ATP binding site [chemical binding]; other site 150340012110 Mg++ binding site [ion binding]; other site 150340012111 motif III; other site 150340012112 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340012113 nucleotide binding region [chemical binding]; other site 150340012114 ATP-binding site [chemical binding]; other site 150340012115 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 150340012116 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 150340012117 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 150340012118 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 150340012119 N-terminal plug; other site 150340012120 ligand-binding site [chemical binding]; other site 150340012121 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 150340012122 Zn binding site [ion binding]; other site 150340012123 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 150340012124 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 150340012125 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340012126 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340012127 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340012128 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340012129 dimerization interface [polypeptide binding]; other site 150340012130 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 150340012131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340012132 dimer interface [polypeptide binding]; other site 150340012133 conserved gate region; other site 150340012134 putative PBP binding loops; other site 150340012135 ABC-ATPase subunit interface; other site 150340012136 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 150340012137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340012138 dimer interface [polypeptide binding]; other site 150340012139 conserved gate region; other site 150340012140 putative PBP binding loops; other site 150340012141 ABC-ATPase subunit interface; other site 150340012142 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14253 150340012143 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 150340012144 Walker A/P-loop; other site 150340012145 ATP binding site [chemical binding]; other site 150340012146 Q-loop/lid; other site 150340012147 ABC transporter signature motif; other site 150340012148 Walker B; other site 150340012149 D-loop; other site 150340012150 H-loop/switch region; other site 150340012151 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340012152 metal binding site [ion binding]; metal-binding site 150340012153 active site 150340012154 I-site; other site 150340012155 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 150340012156 metal ion-dependent adhesion site (MIDAS); other site 150340012157 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 150340012158 Aerotolerance regulator N-terminal; Region: BatA; cl06567 150340012159 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_BatA_type; cd01467 150340012160 metal ion-dependent adhesion site (MIDAS); other site 150340012161 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 150340012162 Protein of unknown function DUF58; Region: DUF58; pfam01882 150340012163 MoxR-like ATPases [General function prediction only]; Region: COG0714 150340012164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340012165 Walker A motif; other site 150340012166 ATP binding site [chemical binding]; other site 150340012167 Walker B motif; other site 150340012168 arginine finger; other site 150340012169 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340012170 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 150340012171 dimerization interface [polypeptide binding]; other site 150340012172 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340012173 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340012174 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 150340012175 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 150340012176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 150340012177 DNA binding residues [nucleotide binding] 150340012178 dimerization interface [polypeptide binding]; other site 150340012179 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 150340012180 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 150340012181 DNA binding residues [nucleotide binding] 150340012182 dimerization interface [polypeptide binding]; other site 150340012183 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 150340012184 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 150340012185 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 150340012186 Walker A/P-loop; other site 150340012187 ATP binding site [chemical binding]; other site 150340012188 Q-loop/lid; other site 150340012189 ABC transporter signature motif; other site 150340012190 Walker B; other site 150340012191 D-loop; other site 150340012192 H-loop/switch region; other site 150340012193 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 150340012194 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 150340012195 Mechanosensitive ion channel; Region: MS_channel; pfam00924 150340012196 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 150340012197 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 150340012198 ABC-ATPase subunit interface; other site 150340012199 dimer interface [polypeptide binding]; other site 150340012200 putative PBP binding regions; other site 150340012201 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 150340012202 ABC-ATPase subunit interface; other site 150340012203 dimer interface [polypeptide binding]; other site 150340012204 putative PBP binding regions; other site 150340012205 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 150340012206 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor...; Region: FhuD; cd01146 150340012207 siderophore binding site; other site 150340012208 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 150340012209 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 150340012210 Walker A/P-loop; other site 150340012211 ATP binding site [chemical binding]; other site 150340012212 Q-loop/lid; other site 150340012213 ABC transporter signature motif; other site 150340012214 Walker B; other site 150340012215 D-loop; other site 150340012216 H-loop/switch region; other site 150340012217 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 150340012218 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 150340012219 N-terminal plug; other site 150340012220 ligand-binding site [chemical binding]; other site 150340012221 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 150340012222 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 150340012223 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 150340012224 Walker A/P-loop; other site 150340012225 ATP binding site [chemical binding]; other site 150340012226 Q-loop/lid; other site 150340012227 ABC transporter signature motif; other site 150340012228 Walker B; other site 150340012229 D-loop; other site 150340012230 H-loop/switch region; other site 150340012231 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 150340012232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340012233 dimer interface [polypeptide binding]; other site 150340012234 phosphorylation site [posttranslational modification] 150340012235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 150340012236 ATP binding site [chemical binding]; other site 150340012237 Mg2+ binding site [ion binding]; other site 150340012238 G-X-G motif; other site 150340012239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 150340012240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340012241 active site 150340012242 phosphorylation site [posttranslational modification] 150340012243 intermolecular recognition site; other site 150340012244 dimerization interface [polypeptide binding]; other site 150340012245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340012246 DNA binding site [nucleotide binding] 150340012247 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 150340012248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340012249 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 150340012250 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 150340012251 Cation transport protein; Region: TrkH; cl10514 150340012252 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 150340012253 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340012254 HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 150340012255 dimerization interface [polypeptide binding]; other site 150340012256 substrate binding pocket [chemical binding]; other site 150340012257 BCCT family transporter; Region: BCCT; cl00569 150340012258 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 150340012259 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 150340012260 [2Fe-2S] cluster binding site [ion binding]; other site 150340012261 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 150340012262 alpha subunit interface [polypeptide binding]; other site 150340012263 active site 150340012264 substrate binding site [chemical binding]; other site 150340012265 Fe binding site [ion binding]; other site 150340012266 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 150340012267 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 150340012268 NAD(P) binding site [chemical binding]; other site 150340012269 catalytic residues [active] 150340012270 Rubredoxin [Energy production and conversion]; Region: COG1773 150340012271 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 150340012272 iron binding site [ion binding]; other site 150340012273 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 150340012274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340012275 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 150340012276 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 150340012277 Cupin domain; Region: Cupin_2; cl09118 150340012278 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340012279 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340012280 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 150340012281 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 150340012282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 150340012283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 150340012284 motif II; other site 150340012285 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 150340012286 GAF domain; Region: GAF; cl00853 150340012287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 150340012288 Walker A motif; other site 150340012289 ATP binding site [chemical binding]; other site 150340012290 Walker B motif; other site 150340012291 arginine finger; other site 150340012292 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 150340012293 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 150340012294 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 150340012295 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 150340012296 iron binding site [ion binding]; other site 150340012297 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 150340012298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340012299 Domain of unknown function (DUF1971); Region: DUF1971; cl01451 150340012300 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 150340012301 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 150340012302 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 150340012303 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 150340012304 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 150340012305 active site 150340012306 phosphorylation site [posttranslational modification] 150340012307 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 150340012308 P-loop; other site 150340012309 active site 150340012310 phosphorylation site [posttranslational modification] 150340012311 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340012312 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340012313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340012314 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 150340012315 dimerization domain swap beta strand [polypeptide binding]; other site 150340012316 regulatory protein interface [polypeptide binding]; other site 150340012317 active site 150340012318 regulatory phosphorylation site [posttranslational modification]; other site 150340012319 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 150340012320 active site 150340012321 phosphorylation site [posttranslational modification] 150340012322 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 150340012323 P-loop; other site 150340012324 active site 150340012325 phosphorylation site [posttranslational modification] 150340012326 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 150340012327 active site 150340012328 phosphorylation site [posttranslational modification] 150340012329 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340012330 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 150340012331 P-loop; other site 150340012332 active site 150340012333 phosphorylation site [posttranslational modification] 150340012334 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 150340012335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340012336 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 150340012337 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 150340012338 tetramer interface [polypeptide binding]; other site 150340012339 heme binding pocket [chemical binding]; other site 150340012340 NADPH binding site [chemical binding]; other site 150340012341 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 150340012342 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins...; Region: GST_N_GTT1_like; cd03046 150340012343 putative C-terminal domain interface [polypeptide binding]; other site 150340012344 putative GSH binding site (G-site) [chemical binding]; other site 150340012345 putative dimer interface [polypeptide binding]; other site 150340012346 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 150340012347 putative N-terminal domain interface [polypeptide binding]; other site 150340012348 putative dimer interface [polypeptide binding]; other site 150340012349 putative substrate binding pocket (H-site) [chemical binding]; other site 150340012350 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 150340012351 Prostaglandin dehydrogenases; Region: PGDH; cd05288 150340012352 NAD(P) binding site [chemical binding]; other site 150340012353 substrate binding site [chemical binding]; other site 150340012354 dimer interface [polypeptide binding]; other site 150340012355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 150340012356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 150340012357 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function...; Region: ASCH_yqfb_like; cd06552 150340012358 MatE; Region: MatE; cl10513 150340012359 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 150340012360 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 150340012361 Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364 150340012362 O-Antigen ligase; Region: Wzy_C; cl04850 150340012363 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 150340012364 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 150340012365 putative ADP-binding pocket [chemical binding]; other site 150340012366 Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364 150340012367 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 150340012368 Chain length determinant protein; Region: Wzz; cl01623 150340012369 Chain length determinant protein; Region: Wzz; cl01623 150340012370 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 150340012371 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 150340012372 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 150340012373 SLBB domain; Region: SLBB; pfam10531 150340012374 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 150340012375 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 150340012376 Bacterial sugar transferase; Region: Bac_transf; cl00939 150340012377 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 150340012378 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 150340012379 Walker A/P-loop; other site 150340012380 ATP binding site [chemical binding]; other site 150340012381 Q-loop/lid; other site 150340012382 ABC transporter signature motif; other site 150340012383 Walker B; other site 150340012384 D-loop; other site 150340012385 H-loop/switch region; other site 150340012386 TOBE domain; Region: TOBE_2; cl01440 150340012387 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340012388 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 150340012389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340012390 dimer interface [polypeptide binding]; other site 150340012391 conserved gate region; other site 150340012392 putative PBP binding loops; other site 150340012393 ABC-ATPase subunit interface; other site 150340012394 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 150340012395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340012396 dimer interface [polypeptide binding]; other site 150340012397 conserved gate region; other site 150340012398 putative PBP binding loops; other site 150340012399 ABC-ATPase subunit interface; other site 150340012400 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 150340012401 EamA-like transporter family; Region: EamA; cl01037 150340012402 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 150340012403 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340012404 A functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site...; Region: Peptidase_M14-like_4; cd06231 150340012405 putative active site [active] 150340012406 Zn-binding site [ion binding]; other site 150340012407 Protein of unknown function (DUF808); Region: DUF808; cl01002 150340012408 Dihydroorotase [Nucleotide transport and metabolism]; Region: PyrC; COG0418 150340012409 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 150340012410 active site 150340012411 substrate binding pocket [chemical binding]; other site 150340012412 dimer interface [polypeptide binding]; other site 150340012413 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 150340012414 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 150340012415 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 150340012416 MOSC domain; Region: MOSC; pfam03473 150340012417 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 150340012418 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 150340012419 FAD binding pocket [chemical binding]; other site 150340012420 FAD binding motif [chemical binding]; other site 150340012421 phosphate binding motif [ion binding]; other site 150340012422 beta-alpha-beta structure motif; other site 150340012423 NAD binding pocket [chemical binding]; other site 150340012424 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 150340012425 catalytic loop [active] 150340012426 iron binding site [ion binding]; other site 150340012427 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 150340012428 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 150340012429 homodimer interface [polypeptide binding]; other site 150340012430 NAD binding pocket [chemical binding]; other site 150340012431 ATP binding pocket [chemical binding]; other site 150340012432 Mg binding site [ion binding]; other site 150340012433 active-site loop [active] 150340012434 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 150340012435 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 150340012436 active site 150340012437 (T/H)XGH motif; other site 150340012438 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 150340012439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340012440 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 150340012441 putative acyl-acceptor binding pocket; other site 150340012442 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 150340012443 Protein of unknown function (DUF406); Region: DUF406; cl11449 150340012444 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 150340012445 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 150340012446 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 150340012447 Walker A/P-loop; other site 150340012448 ATP binding site [chemical binding]; other site 150340012449 Q-loop/lid; other site 150340012450 ABC transporter signature motif; other site 150340012451 Walker B; other site 150340012452 D-loop; other site 150340012453 H-loop/switch region; other site 150340012454 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 150340012455 ABC-ATPase subunit interface; other site 150340012456 dimer interface [polypeptide binding]; other site 150340012457 putative PBP binding regions; other site 150340012458 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 150340012459 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 150340012460 putative hemin binding site; other site 150340012461 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 150340012462 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 150340012463 Gram-negative bacterial tonB protein; Region: TonB; cl10048 150340012464 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 150340012465 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 150340012466 ChuX-like family; Region: DUF1008; cl01509 150340012467 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 150340012468 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 150340012469 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 150340012470 Response regulator receiver domain; Region: Response_reg; pfam00072 150340012471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340012472 active site 150340012473 phosphorylation site [posttranslational modification] 150340012474 intermolecular recognition site; other site 150340012475 dimerization interface [polypeptide binding]; other site 150340012476 PPIC-type PPIASE domain; Region: Rotamase; cl08278 150340012477 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 150340012478 putative homotetramer interface [polypeptide binding]; other site 150340012479 putative homodimer interface [polypeptide binding]; other site 150340012480 putative metal binding site [ion binding]; other site 150340012481 putative homodimer-homodimer interface [polypeptide binding]; other site 150340012482 putative allosteric switch controlling residues; other site 150340012483 High-affinity nickel-transport protein; Region: NicO; cl00964 150340012484 High-affinity nickel-transport protein; Region: NicO; cl00964 150340012485 hypothetical protein; Provisional; Region: PRK09272 150340012486 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 150340012487 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 150340012488 dimerization interface [polypeptide binding]; other site 150340012489 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340012490 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340012491 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340012492 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340012493 putative effector binding pocket; other site 150340012494 dimerization interface [polypeptide binding]; other site 150340012495 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 150340012496 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 150340012497 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 150340012498 Collagenase; Region: Peptidase_M9; pfam01752 150340012499 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 150340012500 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 150340012501 Pas factor saposin fold; Region: Pas_Saposin; pfam09016 150340012502 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 150340012503 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 150340012504 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 150340012505 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 150340012506 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 150340012507 dimerization interface [polypeptide binding]; other site 150340012508 putative DNA binding site [nucleotide binding]; other site 150340012509 putative Zn2+ binding site [ion binding]; other site 150340012510 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 150340012511 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 150340012512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340012513 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 150340012514 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 150340012515 Ligand Binding Site [chemical binding]; other site 150340012516 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 150340012517 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 150340012518 ABC transporter; Region: ABC_tran_2; pfam12848 150340012519 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340012520 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 150340012521 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 150340012522 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 150340012523 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 150340012524 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 150340012525 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 150340012526 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 150340012527 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 150340012528 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 150340012529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340012530 GAF domain; Region: GAF; cl00853 150340012531 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340012532 metal binding site [ion binding]; metal-binding site 150340012533 active site 150340012534 I-site; other site 150340012535 Beta-lactamase; Region: Beta-lactamase; cl01009 150340012536 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 150340012537 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 150340012538 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 150340012539 FAD binding pocket [chemical binding]; other site 150340012540 FAD binding motif [chemical binding]; other site 150340012541 phosphate binding motif [ion binding]; other site 150340012542 beta-alpha-beta structure motif; other site 150340012543 NAD binding pocket [chemical binding]; other site 150340012544 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 150340012545 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 150340012546 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 150340012547 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 150340012548 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 150340012549 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 150340012550 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 150340012551 Outer membrane efflux protein; Region: OEP; pfam02321 150340012552 Outer membrane efflux protein; Region: OEP; pfam02321 150340012553 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 150340012554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340012555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340012556 hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512 150340012557 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_Formate-Dh-H; cd02753 150340012558 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 150340012559 [4Fe-4S] binding site [ion binding]; other site 150340012560 molybdopterin cofactor binding site; other site 150340012561 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_CT_Formate-Dh_H; cd02790 150340012562 molybdopterin cofactor binding site; other site 150340012563 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 150340012564 putative catalytic site [active] 150340012565 putative metal binding site [ion binding]; other site 150340012566 putative phosphate binding site [ion binding]; other site 150340012567 ABC-2 type transporter; Region: ABC2_membrane; cl11417 150340012568 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 150340012569 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340012570 Walker A/P-loop; other site 150340012571 ATP binding site [chemical binding]; other site 150340012572 Q-loop/lid; other site 150340012573 ABC transporter signature motif; other site 150340012574 Walker B; other site 150340012575 D-loop; other site 150340012576 H-loop/switch region; other site 150340012577 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 150340012578 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 150340012579 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 150340012580 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 150340012581 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 150340012582 substrate binding site [chemical binding]; other site 150340012583 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340012584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340012585 Membrane transport protein; Region: Mem_trans; cl09117 150340012586 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 150340012587 putative DNA binding site [nucleotide binding]; other site 150340012588 putative Zn2+ binding site [ion binding]; other site 150340012589 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 150340012590 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 150340012591 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 150340012592 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 150340012593 active site 150340012594 phosphorylation site [posttranslational modification] 150340012595 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 150340012596 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_mannitol; cd05567 150340012597 active site 150340012598 P-loop; other site 150340012599 phosphorylation site [posttranslational modification] 150340012600 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 150340012601 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 150340012602 putative NAD(P) binding site [chemical binding]; other site 150340012603 catalytic Zn binding site [ion binding]; other site 150340012604 Mannitol repressor; Region: MtlR; cl11450 150340012605 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340012606 Active site [active] 150340012607 putative hydrolase; Validated; Region: PRK09248 150340012608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 150340012609 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 150340012610 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 150340012611 Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581 150340012612 Cache domain; Region: Cache_1; pfam02743 150340012613 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340012614 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340012615 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340012616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 150340012617 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 150340012618 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 150340012619 putative peptidase; Provisional; Region: PRK11649 150340012620 Peptidase family M23; Region: Peptidase_M23; pfam01551 150340012621 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340012622 metal binding site [ion binding]; metal-binding site 150340012623 active site 150340012624 I-site; other site 150340012625 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340012626 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340012627 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340012628 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 150340012629 putative effector binding pocket; other site 150340012630 dimerization interface [polypeptide binding]; other site 150340012631 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 150340012632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 150340012633 putative substrate translocation pore; other site 150340012634 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 150340012635 GSH binding site [chemical binding]; other site 150340012636 catalytic residues [active] 150340012637 EamA-like transporter family; Region: EamA; cl01037 150340012638 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 150340012639 trimer interface [polypeptide binding]; other site 150340012640 eyelet of channel; other site 150340012641 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface...; Region: gram_neg_porins; cd00342 150340012642 eyelet of channel; other site 150340012643 trimer interface [polypeptide binding]; other site 150340012644 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 150340012645 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 150340012646 AzlC protein; Region: AzlC; cl00570 150340012647 Cupin domain; Region: Cupin_2; cl09118 150340012648 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340012649 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340012650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340012651 LysE type translocator; Region: LysE; cl00565 150340012652 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340012653 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 150340012654 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 150340012655 active site 150340012656 substrate binding site [chemical binding]; other site 150340012657 metal binding site [ion binding]; metal-binding site 150340012658 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 150340012659 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 150340012660 Cytochrome c; Region: Cytochrom_C; cl11414 150340012661 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 150340012662 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 150340012663 Subunit I/III interface [polypeptide binding]; other site 150340012664 D-pathway; other site 150340012665 Subunit I/VIIc interface [polypeptide binding]; other site 150340012666 Subunit I/IV interface [polypeptide binding]; other site 150340012667 Subunit I/II interface [polypeptide binding]; other site 150340012668 Low-spin heme (heme a) binding site [chemical binding]; other site 150340012669 Subunit I/VIIa interface [polypeptide binding]; other site 150340012670 Subunit I/VIa interface [polypeptide binding]; other site 150340012671 Dimer interface; other site 150340012672 Putative water exit pathway; other site 150340012673 Binuclear center (heme a3/CuB) [ion binding]; other site 150340012674 K-pathway; other site 150340012675 Subunit I/Vb interface [polypeptide binding]; other site 150340012676 Putative proton exit pathway; other site 150340012677 Subunit I/VIb interface; other site 150340012678 Subunit I/VIc interface [polypeptide binding]; other site 150340012679 Electron transfer pathway; other site 150340012680 Subunit I/VIIIb interface [polypeptide binding]; other site 150340012681 Subunit I/VIIb interface [polypeptide binding]; other site 150340012682 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 150340012683 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 150340012684 Subunit III/VIIa interface [polypeptide binding]; other site 150340012685 Phospholipid binding site [chemical binding]; other site 150340012686 Subunit I/III interface [polypeptide binding]; other site 150340012687 Subunit III/VIb interface [polypeptide binding]; other site 150340012688 Subunit III/VIa interface; other site 150340012689 Subunit III/Vb interface [polypeptide binding]; other site 150340012690 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 150340012691 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 150340012692 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 150340012693 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 150340012694 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 150340012695 UbiA prenyltransferase family; Region: UbiA; cl00337 150340012696 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 150340012697 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 150340012698 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 150340012699 catalytic residues [active] 150340012700 hinge region; other site 150340012701 alpha helical domain; other site 150340012702 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340012703 ligand binding site [chemical binding]; other site 150340012704 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 150340012705 YaeQ protein; Region: YaeQ; cl01913 150340012706 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 150340012707 DNA-binding site [nucleotide binding]; DNA binding site 150340012708 RNA-binding motif; other site 150340012709 Domain of unknown function; Region: DUF331; cl01149 150340012710 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 150340012711 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 150340012712 substrate binding pocket [chemical binding]; other site 150340012713 membrane-bound complex binding site; other site 150340012714 hinge residues; other site 150340012715 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340012716 metal binding site [ion binding]; metal-binding site 150340012717 active site 150340012718 I-site; other site 150340012719 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 150340012720 FtsX-like permease family; Region: FtsX; pfam02687 150340012721 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 150340012722 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 150340012723 FtsX-like permease family; Region: FtsX; pfam02687 150340012724 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 150340012725 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 150340012726 Walker A/P-loop; other site 150340012727 ATP binding site [chemical binding]; other site 150340012728 Q-loop/lid; other site 150340012729 ABC transporter signature motif; other site 150340012730 Walker B; other site 150340012731 D-loop; other site 150340012732 H-loop/switch region; other site 150340012733 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 150340012734 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 150340012735 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 150340012736 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340012737 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340012738 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 150340012739 dimerization interface [polypeptide binding]; other site 150340012740 DPS ferroxidase diiron center [ion binding]; other site 150340012741 ion pore; other site 150340012742 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 150340012743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 150340012744 active site 150340012745 motif I; other site 150340012746 motif II; other site 150340012747 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 150340012748 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 150340012749 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 150340012750 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 150340012751 dimer interface [polypeptide binding]; other site 150340012752 active site 150340012753 metal binding site [ion binding]; metal-binding site 150340012754 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 150340012755 conserved cys residue [active] 150340012756 aromatic amino acid exporter; Provisional; Region: PRK11689 150340012757 EamA-like transporter family; Region: EamA; cl01037 150340012758 Cation efflux family; Region: Cation_efflux; cl00316 150340012759 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340012760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340012761 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 150340012762 dimerization interface [polypeptide binding]; other site 150340012763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 150340012764 S-adenosylmethionine binding site [chemical binding]; other site 150340012765 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 150340012766 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 150340012767 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH)...; Region: pro_PheOH; cd03348 150340012768 cofactor binding site; other site 150340012769 metal binding site [ion binding]; metal-binding site 150340012770 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 150340012771 aromatic arch; other site 150340012772 DCoH dimer interaction site [polypeptide binding]; other site 150340012773 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 150340012774 DCoH tetramer interaction site [polypeptide binding]; other site 150340012775 substrate binding site [chemical binding]; other site 150340012776 HopJ type III effector protein; Region: HopJ; pfam08888 150340012777 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 150340012778 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 150340012779 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 150340012780 calcium binding site 2 [ion binding]; other site 150340012781 active site 150340012782 catalytic triad [active] 150340012783 calcium binding site 1 [ion binding]; other site 150340012784 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 150340012785 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 150340012786 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 150340012787 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 150340012788 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 150340012789 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340012790 helicase 45; Provisional; Region: PTZ00424 150340012791 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 150340012792 ATP binding site [chemical binding]; other site 150340012793 Mg++ binding site [ion binding]; other site 150340012794 motif III; other site 150340012795 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340012796 nucleotide binding region [chemical binding]; other site 150340012797 ATP-binding site [chemical binding]; other site 150340012798 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 150340012799 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 150340012800 tryptophan synthase, beta chain; Region: PLN02618 150340012801 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 150340012802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 150340012803 catalytic residue [active] 150340012804 ribonuclease R; Region: RNase_R; TIGR02063 150340012805 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 150340012806 RNB domain; Region: RNB; pfam00773 150340012807 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 150340012808 RNA binding site [nucleotide binding]; other site 150340012809 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 150340012810 DNA-binding site [nucleotide binding]; DNA binding site 150340012811 RNA-binding motif; other site 150340012812 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 150340012813 putative substrate binding pocket [chemical binding]; other site 150340012814 AC domain interface; other site 150340012815 catalytic triad [active] 150340012816 AB domain interface; other site 150340012817 interchain disulfide; other site 150340012818 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 150340012819 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 150340012820 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 150340012821 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 150340012822 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 150340012823 ATP binding site [chemical binding]; other site 150340012824 Mg++ binding site [ion binding]; other site 150340012825 motif III; other site 150340012826 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340012827 nucleotide binding region [chemical binding]; other site 150340012828 ATP-binding site [chemical binding]; other site 150340012829 Arginase family; Region: Arginase; cl00306 150340012830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340012831 Transcriptional regulator [Transcription]; Region: IclR; COG1414 150340012832 Bacterial transcriptional regulator; Region: IclR; pfam01614 150340012833 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 150340012834 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340012835 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 150340012836 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 150340012837 Walker A/P-loop; other site 150340012838 ATP binding site [chemical binding]; other site 150340012839 Q-loop/lid; other site 150340012840 ABC transporter signature motif; other site 150340012841 Walker B; other site 150340012842 D-loop; other site 150340012843 H-loop/switch region; other site 150340012844 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 150340012845 Walker A/P-loop; other site 150340012846 ATP binding site [chemical binding]; other site 150340012847 Q-loop/lid; other site 150340012848 ABC transporter signature motif; other site 150340012849 Walker B; other site 150340012850 D-loop; other site 150340012851 H-loop/switch region; other site 150340012852 PAS fold; Region: PAS_3; pfam08447 150340012853 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 150340012854 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 150340012855 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340012856 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 150340012857 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 150340012858 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 150340012859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 150340012860 non-specific DNA binding site [nucleotide binding]; other site 150340012861 salt bridge; other site 150340012862 sequence-specific DNA binding site [nucleotide binding]; other site 150340012863 multiple promoter invertase; Provisional; Region: mpi; PRK13413 150340012864 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 150340012865 catalytic residues [active] 150340012866 catalytic nucleophile [active] 150340012867 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 150340012868 putative active site [active] 150340012869 putative catalytic site [active] 150340012870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 150340012871 dimerization interface [polypeptide binding]; other site 150340012872 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 150340012873 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 150340012874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340012875 exoribonuclease II; Provisional; Region: PRK05054 150340012876 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 150340012877 RNB domain; Region: RNB; pfam00773 150340012878 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 150340012879 helicase 45; Provisional; Region: PTZ00424 150340012880 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 150340012881 ATP binding site [chemical binding]; other site 150340012882 Mg++ binding site [ion binding]; other site 150340012883 motif III; other site 150340012884 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 150340012885 nucleotide binding region [chemical binding]; other site 150340012886 ATP-binding site [chemical binding]; other site 150340012887 DbpA RNA binding domain; Region: DbpA; pfam03880 150340012888 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340012889 metal binding site [ion binding]; metal-binding site 150340012890 active site 150340012891 I-site; other site 150340012892 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 150340012893 Acetokinase family; Region: Acetate_kinase; cl01029 150340012894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 150340012895 putative active site [active] 150340012896 heme pocket [chemical binding]; other site 150340012897 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 150340012898 PAS fold; Region: PAS_3; pfam08447 150340012899 putative active site [active] 150340012900 heme pocket [chemical binding]; other site 150340012901 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 150340012902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340012903 dimer interface [polypeptide binding]; other site 150340012904 conserved gate region; other site 150340012905 ABC-ATPase subunit interface; other site 150340012906 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 150340012907 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 150340012908 Walker A/P-loop; other site 150340012909 ATP binding site [chemical binding]; other site 150340012910 Q-loop/lid; other site 150340012911 ABC transporter signature motif; other site 150340012912 Walker B; other site 150340012913 D-loop; other site 150340012914 H-loop/switch region; other site 150340012915 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 150340012916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 150340012917 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 150340012918 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 150340012919 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 150340012920 Predicted amidohydrolase [General function prediction only]; Region: COG0388 150340012921 putative active site [active] 150340012922 catalytic triad [active] 150340012923 putative dimer interface [polypeptide binding]; other site 150340012924 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 150340012925 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 150340012926 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 150340012927 conserved cys residue [active] 150340012928 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 150340012929 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 150340012930 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 150340012931 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 150340012932 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 150340012933 active site 150340012934 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 150340012935 FAD binding domain; Region: FAD_binding_4; pfam01565 150340012936 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 150340012937 EamA-like transporter family; Region: EamA; cl01037 150340012938 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 150340012939 active site 150340012940 catalytic residues [active] 150340012941 metal binding site [ion binding]; metal-binding site 150340012942 enoyl-CoA hydratase; Provisional; Region: PRK05995 150340012943 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 150340012944 substrate binding site [chemical binding]; other site 150340012945 oxyanion hole (OAH) forming residues; other site 150340012946 trimer interface [polypeptide binding]; other site 150340012947 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 150340012948 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 150340012949 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 150340012950 substrate binding site [chemical binding]; other site 150340012951 FAD binding site [chemical binding]; other site 150340012952 catalytic base [active] 150340012953 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 150340012954 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 150340012955 DNA binding residues [nucleotide binding] 150340012956 putative dimer interface [polypeptide binding]; other site 150340012957 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 150340012958 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 150340012959 dimer interface [polypeptide binding]; other site 150340012960 active site 150340012961 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 150340012962 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 150340012963 tetrameric interface [polypeptide binding]; other site 150340012964 NAD binding site [chemical binding]; other site 150340012965 catalytic residues [active] 150340012966 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 150340012967 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 150340012968 substrate binding pocket [chemical binding]; other site 150340012969 FAD binding site [chemical binding]; other site 150340012970 catalytic base [active] 150340012971 enoyl-CoA hydratase; Provisional; Region: PRK09076 150340012972 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 150340012973 substrate binding site [chemical binding]; other site 150340012974 oxyanion hole (OAH) forming residues; other site 150340012975 trimer interface [polypeptide binding]; other site 150340012976 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 150340012977 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 150340012978 substrate binding site [chemical binding]; other site 150340012979 oxyanion hole (OAH) forming residues; other site 150340012980 trimer interface [polypeptide binding]; other site 150340012981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340012982 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 150340012983 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 150340012984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340012985 NAD(P) binding site [chemical binding]; other site 150340012986 active site 150340012987 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 150340012988 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 150340012989 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 150340012990 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 150340012991 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 150340012992 D-pathway; other site 150340012993 Putative ubiquinol binding site [chemical binding]; other site 150340012994 Low-spin heme (heme b) binding site [chemical binding]; other site 150340012995 Putative water exit pathway; other site 150340012996 Binuclear center (heme o3/CuB) [ion binding]; other site 150340012997 K-pathway; other site 150340012998 Putative proton exit pathway; other site 150340012999 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 150340013000 Subunit I/III interface [polypeptide binding]; other site 150340013001 Subunit III/IV interface [polypeptide binding]; other site 150340013002 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 150340013003 UbiA prenyltransferase family; Region: UbiA; cl00337 150340013004 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 150340013005 FAD binding domain; Region: FAD_binding_4; pfam01565 150340013006 Berberine and berberine like; Region: BBE; pfam08031 150340013007 Transcriptional regulator [Transcription]; Region: LysR; COG0583 150340013008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 150340013009 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 150340013010 putative dimerization interface [polypeptide binding]; other site 150340013011 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 150340013012 homotrimer interaction site [polypeptide binding]; other site 150340013013 putative active site [active] 150340013014 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 150340013015 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 150340013016 NAD(P) binding site [chemical binding]; other site 150340013017 catalytic residues [active] 150340013018 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 150340013019 active site 150340013020 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 150340013021 Protein of unknown function (DUF3726); Region: DUF3726; pfam12525 150340013022 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 150340013023 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 150340013024 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 150340013025 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 150340013026 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 150340013027 Walker A/P-loop; other site 150340013028 ATP binding site [chemical binding]; other site 150340013029 Q-loop/lid; other site 150340013030 ABC transporter signature motif; other site 150340013031 Walker B; other site 150340013032 D-loop; other site 150340013033 H-loop/switch region; other site 150340013034 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 150340013035 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 150340013036 substrate binding pocket [chemical binding]; other site 150340013037 membrane-bound complex binding site; other site 150340013038 hinge residues; other site 150340013039 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 150340013040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340013041 dimer interface [polypeptide binding]; other site 150340013042 conserved gate region; other site 150340013043 putative PBP binding loops; other site 150340013044 ABC-ATPase subunit interface; other site 150340013045 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 150340013046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340013047 dimer interface [polypeptide binding]; other site 150340013048 conserved gate region; other site 150340013049 putative PBP binding loops; other site 150340013050 ABC-ATPase subunit interface; other site 150340013051 Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+...; Region: 3,4-PCD; cd03459 150340013052 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 150340013053 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 150340013054 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 150340013055 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 150340013056 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 150340013057 ligand binding site [chemical binding]; other site 150340013058 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 150340013059 Outer membrane efflux protein; Region: OEP; pfam02321 150340013060 Outer membrane efflux protein; Region: OEP; pfam02321 150340013061 VCBS repeat; Region: VCBS_repeat; TIGR01965 150340013062 VCBS repeat; Region: VCBS_repeat; TIGR01965 150340013063 VCBS repeat; Region: VCBS_repeat; TIGR01965 150340013064 VCBS repeat; Region: VCBS_repeat; TIGR01965 150340013065 VCBS repeat; Region: VCBS_repeat; TIGR01965 150340013066 VCBS repeat; Region: VCBS_repeat; TIGR01965 150340013067 VCBS repeat; Region: VCBS_repeat; TIGR01965 150340013068 VCBS repeat; Region: VCBS_repeat; TIGR01965 150340013069 VCBS repeat; Region: VCBS_repeat; TIGR01965 150340013070 VCBS repeat; Region: VCBS_repeat; TIGR01965 150340013071 Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium; plays a role in cell...; Region: CA; cl02468 150340013072 Ca2+ binding site [ion binding]; other site 150340013073 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 150340013074 Cadherin repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion; these domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium; plays a role in cell...; Region: CA; cl02468 150340013075 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 150340013076 type 1 secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 150340013077 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 150340013078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 150340013079 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 150340013080 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 150340013081 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 150340013082 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 150340013083 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 150340013084 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 150340013085 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 150340013086 E3 interaction surface; other site 150340013087 lipoyl attachment site [posttranslational modification]; other site 150340013088 e3 binding domain; Region: E3_binding; pfam02817 150340013089 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 150340013090 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 150340013091 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 150340013092 alpha subunit interface [polypeptide binding]; other site 150340013093 TPP binding site [chemical binding]; other site 150340013094 heterodimer interface [polypeptide binding]; other site 150340013095 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 150340013096 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 150340013097 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 150340013098 TPP-binding site [chemical binding]; other site 150340013099 tetramer interface [polypeptide binding]; other site 150340013100 heterodimer interface [polypeptide binding]; other site 150340013101 phosphorylation loop region [posttranslational modification] 150340013102 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562 150340013103 putative chaperone; Provisional; Region: PRK11678 150340013104 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 150340013105 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 150340013106 Protein of unknown function (DUF461); Region: DUF461; cl01071 150340013107 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 150340013108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 150340013109 active site 150340013110 phosphorylation site [posttranslational modification] 150340013111 intermolecular recognition site; other site 150340013112 dimerization interface [polypeptide binding]; other site 150340013113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 150340013114 DNA binding site [nucleotide binding] 150340013115 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 150340013116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 150340013117 dimer interface [polypeptide binding]; other site 150340013118 phosphorylation site [posttranslational modification] 150340013119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 150340013120 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 150340013121 putative hydrophobic ligand binding site [chemical binding]; other site 150340013122 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 150340013123 Peptidase S8 family domain in Protein convertases; Region: Peptidases_S8_Protein_convertases_Kexins_Furin-lik; cd04059 150340013124 calcium binding site 1 [ion binding]; other site 150340013125 active site 150340013126 catalytic triad [active] 150340013127 calcium binding site 2 [ion binding]; other site 150340013128 calcium binding site 3 [ion binding]; other site 150340013129 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 150340013130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 150340013131 TPR motif; other site 150340013132 binding surface 150340013133 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 150340013134 metal binding site [ion binding]; metal-binding site 150340013135 active site 150340013136 I-site; other site 150340013137 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 150340013138 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 150340013139 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 150340013140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 150340013141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 150340013142 Coenzyme A binding pocket [chemical binding]; other site 150340013143 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 150340013144 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 150340013145 molybdopterin cofactor binding site; other site 150340013146 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 150340013147 molybdopterin cofactor binding site; other site 150340013148 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 150340013149 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 150340013150 hypothetical protein; Validated; Region: PRK09071 150340013151 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 150340013152 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 150340013153 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 150340013154 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 150340013155 ANTAR domain; Region: ANTAR; cl04297 150340013156 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 150340013157 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 150340013158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 150340013159 dimer interface [polypeptide binding]; other site 150340013160 conserved gate region; other site 150340013161 putative PBP binding loops; other site 150340013162 ABC-ATPase subunit interface; other site 150340013163 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 150340013164 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 150340013165 Walker A/P-loop; other site 150340013166 ATP binding site [chemical binding]; other site 150340013167 Q-loop/lid; other site 150340013168 ABC transporter signature motif; other site 150340013169 Walker B; other site 150340013170 D-loop; other site 150340013171 H-loop/switch region; other site