-- dump date   	20111121_015612
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1045854000001	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1045854000002	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1045854000003	catalytic residues [active]
1045854000004	catalytic nucleophile [active]
1045854000005	Presynaptic Site I dimer interface [polypeptide binding]; other site
1045854000006	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1045854000007	Synaptic Flat tetramer interface [polypeptide binding]; other site
1045854000008	Synaptic Site I dimer interface [polypeptide binding]; other site
1045854000009	DNA binding site [nucleotide binding]
1045854000010	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1045854000011	DNA-binding interface [nucleotide binding]; DNA binding site
1045854000012	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
1045854000013	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
1045854000014	Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527
1045854000015	Initiator Replication protein; Region: Rep_3; cl03080
1045854000016	Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430
1045854000017	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
1045854000018	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
1045854000019	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
1045854000020	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854000021	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
1045854000022	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1045854000023	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1045854000024	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
1045854000025	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1045854000026	dimerization interface [polypeptide binding]; other site
1045854000027	putative DNA binding site [nucleotide binding]; other site
1045854000028	putative Zn2+ binding site [ion binding]; other site
1045854000029	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1045854000030	active site residue [active]
1045854000031	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1045854000032	catalytic residues [active]
1045854000033	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1045854000034	catalytic residues [active]
1045854000035	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1045854000036	catalytic residues [active]
1045854000037	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1045854000038	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854000039	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854000040	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1045854000041	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1045854000042	catalytic residues [active]
1045854000043	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1045854000044	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854000045	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
1045854000046	phosphate binding site [ion binding]; other site
1045854000047	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1045854000048	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1045854000049	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1045854000050	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1045854000051	putative NAD(P) binding site [chemical binding]; other site
1045854000052	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1045854000053	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1045854000054	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1045854000055	ligand binding site [chemical binding]; other site
1045854000056	flexible hinge region; other site
1045854000057	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854000058	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1045854000059	metal-binding site [ion binding]
1045854000060	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1045854000061	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1045854000062	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
1045854000063	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1045854000064	Zn binding site [ion binding]; other site
1045854000065	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1045854000066	Zn binding site [ion binding]; other site
1045854000067	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1045854000068	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1045854000069	active site
1045854000070	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
1045854000071	putative peptidoglycan binding site; other site
1045854000072	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins...; Region: GH25_BacA-like; cd06418
1045854000073	active site
1045854000074	YcfA-like protein; Region: YcfA; cl00752
1045854000075	PemK-like protein; Region: PemK; cl00995
1045854000076	Protein of unknown function (DUF1498); Region: DUF1498; cl01576
1045854000077	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228
1045854000078	nucleotide binding site/active site [active]
1045854000079	HIT family signature motif; other site
1045854000080	catalytic residue [active]
1045854000081	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1045854000082	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
1045854000083	NAD(P) binding site [chemical binding]; other site
1045854000084	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1045854000085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854000086	putative substrate translocation pore; other site
1045854000087	Cupin domain; Region: Cupin_2; cl09118
1045854000088	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1045854000089	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1045854000090	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
1045854000091	PYR/PP interface [polypeptide binding]; other site
1045854000092	tetramer interface [polypeptide binding]; other site
1045854000093	dimer interface [polypeptide binding]; other site
1045854000094	TPP binding site [chemical binding]; other site
1045854000095	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1045854000096	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014
1045854000097	TPP-binding site [chemical binding]; other site
1045854000098	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854000099	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1045854000100	Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382
1045854000101	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1045854000102	Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012
1045854000103	Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012
1045854000104	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
1045854000105	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
1045854000106	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1045854000107	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
1045854000108	SecY translocase; Region: SecY; pfam00344
1045854000109	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
1045854000110	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1045854000111	ATP binding site [chemical binding]; other site
1045854000112	putative Mg++ binding site [ion binding]; other site
1045854000113	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
1045854000114	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1045854000115	nucleotide binding region [chemical binding]; other site
1045854000116	ATP-binding site [chemical binding]; other site
1045854000117	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
1045854000118	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1045854000119	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
1045854000120	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1045854000121	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1045854000122	Sulfate transporter family; Region: Sulfate_transp; cl00967
1045854000123	Permease family; Region: Xan_ur_permease; pfam00860
1045854000124	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1045854000125	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1045854000126	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
1045854000127	Plastocyanin domain containing protein [General function prediction only]; Region: COG4633
1045854000128	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
1045854000129	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854000130	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
1045854000131	ligand binding site [chemical binding]; other site
1045854000132	flexible hinge region; other site
1045854000133	hypothetical protein; Provisional; Region: PRK07205
1045854000134	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1045854000135	active site
1045854000136	metal binding site [ion binding]; metal-binding site
1045854000137	Predicted membrane protein [Function unknown]; Region: COG1288
1045854000138	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
1045854000139	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854000140	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1045854000141	putative substrate translocation pore; other site
1045854000142	GTP-binding protein LepA; Provisional; Region: PRK05433
1045854000143	LepA subfamily.  LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome.  LepA is ubiquitous in bacteria and...; Region: LepA; cd01890
1045854000144	G1 box; other site
1045854000145	putative GEF interaction site [polypeptide binding]; other site
1045854000146	GTP/Mg2+ binding site [chemical binding]; other site
1045854000147	Switch I region; other site
1045854000148	G2 box; other site
1045854000149	G3 box; other site
1045854000150	Switch II region; other site
1045854000151	G4 box; other site
1045854000152	G5 box; other site
1045854000153	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787
1045854000154	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1045854000155	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1045854000156	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
1045854000157	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1045854000158	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1045854000159	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1045854000160	ABC-2 type transporter; Region: ABC2_membrane; cl11417
1045854000161	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1045854000162	The ABCA subfamily mediates the transport of a variety of lipid compounds.  Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency...; Region: ABC_subfamily_A; cd03263
1045854000163	Walker A/P-loop; other site
1045854000164	ATP binding site [chemical binding]; other site
1045854000165	Q-loop/lid; other site
1045854000166	ABC transporter signature motif; other site
1045854000167	Walker B; other site
1045854000168	D-loop; other site
1045854000169	H-loop/switch region; other site
1045854000170	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947
1045854000171	hypothetical protein; Provisional; Region: PRK08185
1045854000172	intersubunit interface [polypeptide binding]; other site
1045854000173	active site
1045854000174	zinc binding site [ion binding]; other site
1045854000175	Na+ binding site [ion binding]; other site
1045854000176	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl01869
1045854000177	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
1045854000178	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
1045854000179	peptidase T; Region: peptidase-T; TIGR01882
1045854000180	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1045854000181	metal binding site [ion binding]; metal-binding site
1045854000182	dimer interface [polypeptide binding]; other site
1045854000183	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1045854000184	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412
1045854000185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
1045854000186	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1045854000187	active site
1045854000188	multimer interface [polypeptide binding]; other site
1045854000189	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429
1045854000190	binding surface
1045854000191	TPR motif; other site
1045854000192	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
1045854000193	binding surface
1045854000194	TPR motif; other site
1045854000195	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
1045854000196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
1045854000197	binding surface
1045854000198	TPR motif; other site
1045854000199	cyanate transporter; Region: CynX; TIGR00896
1045854000200	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854000201	putative substrate translocation pore; other site
1045854000202	Protein of unknown function (DUF1393); Region: DUF1393; cl01942
1045854000203	bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427
1045854000204	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1045854000205	dimer interface [polypeptide binding]; other site
1045854000206	substrate binding site [chemical binding]; other site
1045854000207	ATP binding site [chemical binding]; other site
1045854000208	DNA polymerase I; Provisional; Region: PRK05755
1045854000209	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1045854000210	active site
1045854000211	metal binding site 1 [ion binding]; metal-binding site
1045854000212	putative 5' ssDNA interaction site; other site
1045854000213	metal binding site 3; metal-binding site
1045854000214	metal binding site 2 [ion binding]; metal-binding site
1045854000215	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1045854000216	putative DNA binding site [nucleotide binding]; other site
1045854000217	putative metal binding site [ion binding]; other site
1045854000218	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1045854000219	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1045854000220	active site
1045854000221	DNA binding site [nucleotide binding]
1045854000222	catalytic site [active]
1045854000223	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1045854000224	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
1045854000225	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1045854000226	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854000227	Walker A/P-loop; other site
1045854000228	ATP binding site [chemical binding]; other site
1045854000229	Q-loop/lid; other site
1045854000230	ABC transporter signature motif; other site
1045854000231	Walker B; other site
1045854000232	D-loop; other site
1045854000233	H-loop/switch region; other site
1045854000234	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1045854000235	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1045854000236	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1045854000237	putative NAD(P) binding site [chemical binding]; other site
1045854000238	dimer interface [polypeptide binding]; other site
1045854000239	DNA topoisomerase III; Provisional; Region: PRK07726
1045854000240	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by:...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1045854000241	active site
1045854000242	putative interdomain interaction site [polypeptide binding]; other site
1045854000243	putative metal-binding site [ion binding]; other site
1045854000244	putative nucleotide binding site [chemical binding]; other site
1045854000245	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
1045854000246	domain I; other site
1045854000247	DNA binding groove [nucleotide binding]
1045854000248	phosphate binding site [ion binding]; other site
1045854000249	domain II; other site
1045854000250	domain III; other site
1045854000251	nucleotide binding site [chemical binding]; other site
1045854000252	catalytic site [active]
1045854000253	domain IV; other site
1045854000254	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
1045854000255	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1045854000256	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381
1045854000257	active site
1045854000258	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1045854000259	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1045854000260	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854000261	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854000262	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1045854000263	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1045854000264	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
1045854000265	dimer interface [polypeptide binding]; other site
1045854000266	conserved gate region; other site
1045854000267	putative PBP binding loops; other site
1045854000268	ABC-ATPase subunit interface; other site
1045854000269	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1045854000270	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
1045854000271	substrate binding pocket [chemical binding]; other site
1045854000272	membrane-bound complex binding site; other site
1045854000273	hinge residues; other site
1045854000274	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
1045854000275	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1045854000276	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
1045854000277	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1045854000278	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
1045854000279	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1045854000280	active site
1045854000281	(T/H)XGH motif; other site
1045854000282	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
1045854000283	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453
1045854000284	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1045854000285	TypA (tyrosine phosphorylated protein A)/BipA subfamily.  BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants.  BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891
1045854000286	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
1045854000287	G1 box; other site
1045854000288	putative GEF interaction site [polypeptide binding]; other site
1045854000289	GTP/Mg2+ binding site [chemical binding]; other site
1045854000290	Switch I region; other site
1045854000291	G2 box; other site
1045854000292	G3 box; other site
1045854000293	Switch II region; other site
1045854000294	G4 box; other site
1045854000295	G5 box; other site
1045854000296	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1045854000297	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a...; Region: BipA_TypA_C; cd03710
1045854000298	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1,6-; Region: IMPase_like; cd01637
1045854000299	active site
1045854000300	Uncharacterised protein family (UPF0223); Region: UPF0223; cl11484
1045854000301	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487
1045854000302	active site
1045854000303	catalytic residues [active]
1045854000304	metal binding site [ion binding]; metal-binding site
1045854000305	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
1045854000306	Protein of unknown function (DUF1447); Region: DUF1447; cl11492
1045854000307	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1045854000308	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1045854000309	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1045854000310	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1045854000311	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
1045854000312	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1045854000313	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
1045854000314	DHHA2 domain; Region: DHHA2; pfam02833
1045854000315	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1045854000316	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
1045854000317	CAP-like domain; other site
1045854000318	Active site [active]
1045854000319	primary dimer interface [polypeptide binding]; other site
1045854000320	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1045854000321	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1045854000322	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1045854000323	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
1045854000324	anchoring element; other site
1045854000325	dimer interface [polypeptide binding]; other site
1045854000326	ATP binding site [chemical binding]; other site
1045854000327	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1045854000328	active site
1045854000329	putative metal-binding site [ion binding]; other site
1045854000330	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1045854000331	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1045854000332	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1045854000333	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1045854000334	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1045854000335	GTP1/OBG; Region: GTP1_OBG; pfam01018
1045854000336	Obg subfamily.  The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation.  Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898
1045854000337	G1 box; other site
1045854000338	GTP/Mg2+ binding site [chemical binding]; other site
1045854000339	Switch I region; other site
1045854000340	G2 box; other site
1045854000341	G3 box; other site
1045854000342	Switch II region; other site
1045854000343	G4 box; other site
1045854000344	G5 box; other site
1045854000345	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
1045854000346	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1045854000347	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1045854000348	GIY-YIG motif/motif A; other site
1045854000349	active site
1045854000350	catalytic site [active]
1045854000351	putative DNA binding site [nucleotide binding]; other site
1045854000352	metal binding site [ion binding]; metal-binding site
1045854000353	UvrB/uvrC motif; Region: UVR; pfam02151
1045854000354	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1045854000355	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
1045854000356	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1045854000357	catalytic core [active]
1045854000358	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1045854000359	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
1045854000360	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1045854000361	RimM N-terminal domain; Region: RimM; pfam01782
1045854000362	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959
1045854000363	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854000364	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854000365	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1045854000366	putative substrate translocation pore; other site
1045854000367	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854000368	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
1045854000369	signal recognition particle protein; Provisional; Region: PRK10867
1045854000370	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
1045854000371	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1045854000372	P loop; other site
1045854000373	GTP binding site [chemical binding]; other site
1045854000374	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1045854000375	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
1045854000376	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1045854000377	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1045854000378	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
1045854000379	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1045854000380	P loop; other site
1045854000381	GTP binding site [chemical binding]; other site
1045854000382	ribonuclease III; Reviewed; Region: rnc; PRK00102
1045854000383	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593
1045854000384	dimerization interface [polypeptide binding]; other site
1045854000385	active site
1045854000386	metal binding site [ion binding]; metal-binding site
1045854000387	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048
1045854000388	dsRNA binding site [nucleotide binding]; other site
1045854000389	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1045854000390	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
1045854000391	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1045854000392	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488
1045854000393	generic binding surface II; other site
1045854000394	ssDNA binding site; other site
1045854000395	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1045854000396	ATP binding site [chemical binding]; other site
1045854000397	putative Mg++ binding site [ion binding]; other site
1045854000398	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1045854000399	nucleotide binding region [chemical binding]; other site
1045854000400	Sulfate transporter family; Region: Sulfate_transp; cl00967
1045854000401	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
1045854000402	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
1045854000403	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1045854000404	active site
1045854000405	HIGH motif; other site
1045854000406	KMSK motif region; other site
1045854000407	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1045854000408	tRNA binding surface [nucleotide binding]; other site
1045854000409	anticodon binding site; other site
1045854000410	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1045854000411	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1045854000412	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1045854000413	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
1045854000414	Peptidase family M48; Region: Peptidase_M48; cl12018
1045854000415	LemA family; Region: LemA; cl00742
1045854000416	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1045854000417	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799
1045854000418	active site
1045854000419	substrate binding site [chemical binding]; other site
1045854000420	metal binding site [ion binding]; metal-binding site
1045854000421	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1045854000422	DAK2 domain; Region: Dak2; cl03685
1045854000423	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614
1045854000424	Protein of unknown function (DUF322); Region: DUF322; cl00574
1045854000425	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
1045854000426	Thiamine pyrophosphokinase; Region: TPK; cd07995
1045854000427	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
1045854000428	active site
1045854000429	dimerization interface [polypeptide binding]; other site
1045854000430	thiamine binding site [chemical binding]; other site
1045854000431	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429
1045854000432	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1045854000433	substrate binding site [chemical binding]; other site
1045854000434	hexamer interface [polypeptide binding]; other site
1045854000435	metal binding site [ion binding]; metal-binding site
1045854000436	GTPase RsgA; Reviewed; Region: PRK00098
1045854000437	YjeQ/EngC.  YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854
1045854000438	GTPase/OB domain interface [polypeptide binding]; other site
1045854000439	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1045854000440	GTP/Mg2+ binding site [chemical binding]; other site
1045854000441	G4 box; other site
1045854000442	G5 box; other site
1045854000443	G1 box; other site
1045854000444	Switch I region; other site
1045854000445	G2 box; other site
1045854000446	G3 box; other site
1045854000447	Switch II region; other site
1045854000448	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1045854000449	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1045854000450	active site
1045854000451	ATP binding site [chemical binding]; other site
1045854000452	substrate binding site [chemical binding]; other site
1045854000453	activation loop (A-loop); other site
1045854000454	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
1045854000455	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
1045854000456	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577
1045854000457	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
1045854000458	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1045854000459	Active site [active]
1045854000460	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1045854000461	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223
1045854000462	putative RNA binding site [nucleotide binding]; other site
1045854000463	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
1045854000464	S-adenosylmethionine binding site [chemical binding]; other site
1045854000465	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1045854000466	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1045854000467	putative active site [active]
1045854000468	substrate binding site [chemical binding]; other site
1045854000469	putative cosubstrate binding site; other site
1045854000470	catalytic site [active]
1045854000471	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1045854000472	substrate binding site [chemical binding]; other site
1045854000473	primosome assembly protein PriA; Validated; Region: PRK05580
1045854000474	primosome assembly protein PriA; Validated; Region: PRK05580
1045854000475	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1045854000476	ATP binding site [chemical binding]; other site
1045854000477	putative Mg++ binding site [ion binding]; other site
1045854000478	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854000479	Acetokinase family; Region: Acetate_kinase; cl01029
1045854000480	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
1045854000481	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1045854000482	Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830
1045854000483	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1045854000484	Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906
1045854000485	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854000486	Walker A motif; other site
1045854000487	ATP binding site [chemical binding]; other site
1045854000488	Walker B motif; other site
1045854000489	Domain of unknown function DUF28; Region: DUF28; cl00361
1045854000490	glycerol kinase; Provisional; Region: glpK; PRK00047
1045854000491	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1045854000492	N- and C-terminal domain interface [polypeptide binding]; other site
1045854000493	active site
1045854000494	MgATP binding site [chemical binding]; other site
1045854000495	catalytic site [active]
1045854000496	metal binding site [ion binding]; metal-binding site
1045854000497	glycerol binding site [chemical binding]; other site
1045854000498	homotetramer interface [polypeptide binding]; other site
1045854000499	homodimer interface [polypeptide binding]; other site
1045854000500	FBP binding site [chemical binding]; other site
1045854000501	protein IIAGlc interface [polypeptide binding]; other site
1045854000502	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1045854000503	active site 1 [active]
1045854000504	dimer interface [polypeptide binding]; other site
1045854000505	hexamer interface [polypeptide binding]; other site
1045854000506	active site 2 [active]
1045854000507	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1045854000508	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1045854000509	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1045854000510	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
1045854000511	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
1045854000512	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1045854000513	ATP binding site [chemical binding]; other site
1045854000514	Mg++ binding site [ion binding]; other site
1045854000515	motif III; other site
1045854000516	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1045854000517	nucleotide binding region [chemical binding]; other site
1045854000518	ATP-binding site [chemical binding]; other site
1045854000519	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1045854000520	DHH family; Region: DHH; pfam01368
1045854000521	DHHA1 domain; Region: DHHA1; pfam02272
1045854000522	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1045854000523	active site
1045854000524	DNA polymerase IV; Validated; Region: PRK02406
1045854000525	DNA binding site [nucleotide binding]
1045854000526	Preprotein translocase subunit; Region: YajC; cl00806
1045854000527	Queuine tRNA-ribosyltransferase; Region: TGT; cl00409
1045854000528	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
1045854000529	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1045854000530	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1045854000531	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
1045854000532	Walker A motif; other site
1045854000533	ATP binding site [chemical binding]; other site
1045854000534	Walker B motif; other site
1045854000535	arginine finger; other site
1045854000536	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1045854000537	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1045854000538	RuvA N terminal domain; Region: RuvA_N; pfam01330
1045854000539	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1045854000540	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
1045854000541	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
1045854000542	DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
1045854000543	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1045854000544	RNA/DNA hybrid binding site [nucleotide binding]; other site
1045854000545	active site
1045854000546	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
1045854000547	YlqF.  Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856
1045854000548	GTP/Mg2+ binding site [chemical binding]; other site
1045854000549	G4 box; other site
1045854000550	G5 box; other site
1045854000551	G1 box; other site
1045854000552	Switch I region; other site
1045854000553	G2 box; other site
1045854000554	G3 box; other site
1045854000555	Switch II region; other site
1045854000556	Protein of unknown function (DUF1250); Region: DUF1250; cl11485
1045854000557	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548
1045854000558	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
1045854000559	active site
1045854000560	catalytic triad [active]
1045854000561	oxyanion hole [active]
1045854000562	Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577
1045854000563	Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577
1045854000564	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1045854000565	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854000566	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1045854000567	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854000568	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1045854000569	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1045854000570	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054
1045854000571	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
1045854000572	dimer interface [polypeptide binding]; other site
1045854000573	phosphorylation site [posttranslational modification]
1045854000574	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1045854000575	ATP binding site [chemical binding]; other site
1045854000576	Mg2+ binding site [ion binding]; other site
1045854000577	G-X-G motif; other site
1045854000578	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1045854000579	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
1045854000580	active site
1045854000581	phosphorylation site [posttranslational modification]
1045854000582	intermolecular recognition site; other site
1045854000583	dimerization interface [polypeptide binding]; other site
1045854000584	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
1045854000585	DNA binding site [nucleotide binding]
1045854000586	YibE/F-like protein; Region: YibE_F; cl02259
1045854000587	YibE/F-like protein; Region: YibE_F; cl02259
1045854000588	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1045854000589	primosomal protein DnaI; Reviewed; Region: PRK08939
1045854000590	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
1045854000591	Walker A motif; other site
1045854000592	ATP binding site [chemical binding]; other site
1045854000593	Walker B motif; other site
1045854000594	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1045854000595	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
1045854000596	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1045854000597	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1045854000598	CoA-binding site [chemical binding]; other site
1045854000599	ATP-binding [chemical binding]; other site
1045854000600	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1045854000601	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1045854000602	DNA binding site [nucleotide binding]
1045854000603	catalytic residue [active]
1045854000604	H2TH interface [polypeptide binding]; other site
1045854000605	putative catalytic residues [active]
1045854000606	turnover-facilitating residue; other site
1045854000607	intercalation triad [nucleotide binding]; other site
1045854000608	8OG recognition residue [nucleotide binding]; other site
1045854000609	putative reading head residues; other site
1045854000610	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1045854000611	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1045854000612	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
1045854000613	active site
1045854000614	catalytic residues [active]
1045854000615	DNA topoisomerase I; Validated; Region: PRK05582
1045854000616	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363
1045854000617	active site
1045854000618	interdomain interaction site; other site
1045854000619	putative metal-binding site [ion binding]; other site
1045854000620	nucleotide binding site [chemical binding]; other site
1045854000621	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186
1045854000622	domain I; other site
1045854000623	DNA binding groove [nucleotide binding]
1045854000624	phosphate binding site [ion binding]; other site
1045854000625	domain II; other site
1045854000626	domain III; other site
1045854000627	nucleotide binding site [chemical binding]; other site
1045854000628	catalytic site [active]
1045854000629	domain IV; other site
1045854000630	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
1045854000631	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977
1045854000632	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
1045854000633	S-adenosylmethionine binding site [chemical binding]; other site
1045854000634	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277
1045854000635	HIT family signature motif; other site
1045854000636	catalytic residue [active]
1045854000637	Protein of unknown function (DUF1304); Region: DUF1304; cl01533
1045854000638	TspO/MBR family; Region: TspO_MBR; cl01379
1045854000639	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1045854000640	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
1045854000641	active site
1045854000642	catalytic tetrad [active]
1045854000643	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1045854000644	trimer interface [polypeptide binding]; other site
1045854000645	active site
1045854000646	substrate binding site [chemical binding]; other site
1045854000647	CoA binding site [chemical binding]; other site
1045854000648	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1045854000649	classical (c) SDRs; Region: SDR_c; cd05233
1045854000650	NAD(P) binding site [chemical binding]; other site
1045854000651	active site
1045854000652	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1045854000653	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854000654	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1045854000655	dimerization interface [polypeptide binding]; other site
1045854000656	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450
1045854000657	conserved hypothetical integral membrane protein; Region: TIGR03766
1045854000658	CsbD-like; Region: CsbD; cl01272
1045854000659	CsbD-like; Region: CsbD; cl01272
1045854000660	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1045854000661	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1045854000662	Coenzyme A binding pocket [chemical binding]; other site
1045854000663	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1045854000664	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1045854000665	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
1045854000666	S-adenosylmethionine binding site [chemical binding]; other site
1045854000667	Protein of unknown function (DUF1696); Region: DUF1696; pfam08000
1045854000668	PQ loop repeat; Region: PQ-loop; cl12056
1045854000669	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; cl12126
1045854000670	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
1045854000671	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1045854000672	Coenzyme A binding pocket [chemical binding]; other site
1045854000673	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854000674	Walker A motif; other site
1045854000675	ATP binding site [chemical binding]; other site
1045854000676	Walker B motif; other site
1045854000677	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
1045854000678	Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691
1045854000679	YcfA-like protein; Region: YcfA; cl00752
1045854000680	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1045854000681	non-specific DNA binding site [nucleotide binding]; other site
1045854000682	salt bridge; other site
1045854000683	sequence-specific DNA binding site [nucleotide binding]; other site
1045854000684	Domain of unknown function (DUF955); Region: DUF955; cl01076
1045854000685	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
1045854000686	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
1045854000687	integron integrase; Region: integrase_gron; TIGR02249
1045854000688	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1045854000689	Phage integrase family; Region: Phage_integrase; pfam00589
1045854000690	Int/Topo IB signature motif; other site
1045854000691	catabolite control protein A; Region: ccpA; TIGR01481
1045854000692	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1045854000693	DNA binding site [nucleotide binding]
1045854000694	domain linker motif; other site
1045854000695	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1045854000696	dimerization interface [polypeptide binding]; other site
1045854000697	effector binding site; other site
1045854000698	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1045854000699	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1045854000700	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1045854000701	active site
1045854000702	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1045854000703	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1045854000704	dimer interface [polypeptide binding]; other site
1045854000705	putative radical transfer pathway; other site
1045854000706	diiron center [ion binding]; other site
1045854000707	tyrosyl radical; other site
1045854000708	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
1045854000709	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1045854000710	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1045854000711	active site
1045854000712	dimer interface [polypeptide binding]; other site
1045854000713	catalytic residues [active]
1045854000714	effector binding site; other site
1045854000715	R2 peptide binding site; other site
1045854000716	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976
1045854000717	catalytic residues [active]
1045854000718	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
1045854000719	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854000720	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1045854000721	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1045854000722	active site
1045854000723	HIGH motif; other site
1045854000724	nucleotide binding site [chemical binding]; other site
1045854000725	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1045854000726	active site
1045854000727	KMSKS motif; other site
1045854000728	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1045854000729	tRNA binding surface [nucleotide binding]; other site
1045854000730	anticodon binding site; other site
1045854000731	DivIVA protein; Region: DivIVA; pfam05103
1045854000732	DivIVA domain; Region: DivI1A_domain; TIGR03544
1045854000733	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1045854000734	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1045854000735	RNA binding surface [nucleotide binding]; other site
1045854000736	YGGT family; Region: YGGT; cl00508
1045854000737	Protein of unknown function (DUF552); Region: DUF552; cl00775
1045854000738	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201
1045854000739	nucleotide binding site [chemical binding]; other site
1045854000740	SulA interaction site; other site
1045854000741	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1045854000742	Cell division protein FtsA; Region: FtsA; cl11496
1045854000743	Cell division protein FtsA; Region: FtsA; cl11496
1045854000744	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1045854000745	Cell division protein FtsQ; Region: FtsQ; pfam03799
1045854000746	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1045854000747	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785
1045854000748	active site
1045854000749	homodimer interface [polypeptide binding]; other site
1045854000750	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1045854000751	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854000752	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1045854000753	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1045854000754	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852
1045854000755	Mg++ binding site [ion binding]; other site
1045854000756	putative catalytic motif [active]
1045854000757	putative substrate binding site [chemical binding]; other site
1045854000758	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1045854000759	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1045854000760	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
1045854000761	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1045854000762	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1045854000763	Septum formation initiator; Region: DivIC; cl11433
1045854000764	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1045854000765	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
1045854000766	cell division protein MraZ; Reviewed; Region: PRK00326
1045854000767	MraZ protein; Region: MraZ; pfam02381
1045854000768	MraZ protein; Region: MraZ; pfam02381
1045854000769	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
1045854000770	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
1045854000771	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
1045854000772	S-adenosylmethionine binding site [chemical binding]; other site
1045854000773	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
1045854000774	Amino acid permease; Region: AA_permease; pfam00324
1045854000775	Protein of unknown function (DUF1634); Region: DUF1634; cl01741
1045854000776	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
1045854000777	rod shape-determining protein MreC; Region: MreC; pfam04085
1045854000778	rod shape-determining protein MreB; Provisional; Region: PRK13927
1045854000779	Cell division protein FtsA; Region: FtsA; cl11496
1045854000780	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1045854000781	MPN+ (JAMM) motif; other site
1045854000782	Zinc-binding site [ion binding]; other site
1045854000783	Uncharacterized conserved protein [Function unknown]; Region: COG4748
1045854000784	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1045854000785	CAAX amino terminal protease self- immunity; Region: Abi; cl00558
1045854000786	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1045854000787	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
1045854000788	active site
1045854000789	motif I; other site
1045854000790	motif II; other site
1045854000791	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
1045854000792	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399
1045854000793	active site
1045854000794	trimer interface [polypeptide binding]; other site
1045854000795	allosteric site; other site
1045854000796	active site lid [active]
1045854000797	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1045854000798	Cupin domain; Region: Cupin_2; cl09118
1045854000799	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1045854000800	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1045854000801	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1045854000802	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
1045854000803	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228
1045854000804	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228
1045854000805	galactokinase; Provisional; Region: PRK05322
1045854000806	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1045854000807	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
1045854000808	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1045854000809	putative transporter; Provisional; Region: PRK11462
1045854000810	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1045854000811	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1045854000812	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1045854000813	Isochorismatase family; Region: Isochorismatase; pfam00857
1045854000814	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1045854000815	catalytic triad [active]
1045854000816	conserved cis-peptide bond; other site
1045854000817	DsrE/DsrF-like family; Region: DrsE; cl00672
1045854000818	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
1045854000819	GTP-binding protein LepA; Provisional; Region: PRK05433
1045854000820	LepA subfamily.  LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome.  LepA is ubiquitous in bacteria and...; Region: LepA; cd01890
1045854000821	G1 box; other site
1045854000822	putative GEF interaction site [polypeptide binding]; other site
1045854000823	GTP/Mg2+ binding site [chemical binding]; other site
1045854000824	Switch I region; other site
1045854000825	G2 box; other site
1045854000826	G3 box; other site
1045854000827	Switch II region; other site
1045854000828	G4 box; other site
1045854000829	G5 box; other site
1045854000830	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699
1045854000831	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1045854000832	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1045854000833	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
1045854000834	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
1045854000835	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1045854000836	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492
1045854000837	generic binding surface I; other site
1045854000838	generic binding surface II; other site
1045854000839	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
1045854000840	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1045854000841	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854000842	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1045854000843	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1045854000844	active site
1045854000845	metal binding site [ion binding]; metal-binding site
1045854000846	DNA binding site [nucleotide binding]
1045854000847	Protein of unknown function (DUF964); Region: DUF964; cl01483
1045854000848	Transglycosylase; Region: Transgly; cl07896
1045854000849	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1045854000850	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
1045854000851	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1045854000852	Arginine repressor [Transcription]; Region: ArgR; COG1438
1045854000853	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1045854000854	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1045854000855	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
1045854000856	Walker A/P-loop; other site
1045854000857	ATP binding site [chemical binding]; other site
1045854000858	Q-loop/lid; other site
1045854000859	ABC transporter signature motif; other site
1045854000860	Walker B; other site
1045854000861	D-loop; other site
1045854000862	H-loop/switch region; other site
1045854000863	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
1045854000864	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353
1045854000865	16S/18S rRNA binding site [nucleotide binding]; other site
1045854000866	S13e-L30e interaction site [polypeptide binding]; other site
1045854000867	25S rRNA binding site [nucleotide binding]; other site
1045854000868	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1045854000869	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1045854000870	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
1045854000871	Competence protein; Region: Competence; cl00471
1045854000872	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1045854000873	SLBB domain; Region: SLBB; pfam10531
1045854000874	comEA protein; Region: comE; TIGR01259
1045854000875	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1045854000876	Protein of unknown function (DUF1700); Region: DUF1700; cl01933
1045854000877	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854000878	Protein of unknown function (DUF1292); Region: DUF1292; cl01608
1045854000879	Protein of unknown function (DUF1292); Region: DUF1292; cl01608
1045854000880	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
1045854000881	Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857
1045854000882	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1045854000883	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673
1045854000884	motif 1; other site
1045854000885	active site
1045854000886	motif 2; other site
1045854000887	motif 3; other site
1045854000888	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
1045854000889	DHHA1 domain; Region: DHHA1; pfam02272
1045854000890	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854000891	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1045854000892	putative substrate translocation pore; other site
1045854000893	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1045854000894	MgtE intracellular N domain; Region: MgtE_N; cl15244
1045854000895	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1045854000896	Divalent cation transporter; Region: MgtE; cl00786
1045854000897	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1045854000898	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
1045854000899	active site
1045854000900	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
1045854000901	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1045854000902	synthetase active site [active]
1045854000903	NTP binding site [chemical binding]; other site
1045854000904	metal binding site [ion binding]; metal-binding site
1045854000905	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854000906	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1045854000907	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854000908	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1045854000909	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
1045854000910	Probable Catalytic site [active]
1045854000911	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
1045854000912	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071
1045854000913	catalytic site [active]
1045854000914	G-X2-G-X-G-K; other site
1045854000915	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1045854000916	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
1045854000917	Walker A/P-loop; other site
1045854000918	ATP binding site [chemical binding]; other site
1045854000919	Q-loop/lid; other site
1045854000920	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241
1045854000921	ABC transporter signature motif; other site
1045854000922	Walker B; other site
1045854000923	D-loop; other site
1045854000924	H-loop/switch region; other site
1045854000925	arginine repressor; Provisional; Region: PRK04280
1045854000926	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1045854000927	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1045854000928	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1045854000929	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1045854000930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
1045854000931	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1045854000932	substrate binding pocket [chemical binding]; other site
1045854000933	chain length determination region; other site
1045854000934	substrate-Mg2+ binding site; other site
1045854000935	aspartate-rich region 1; other site
1045854000936	catalytic residues [active]
1045854000937	active site lid residues [active]
1045854000938	aspartate-rich region 2; other site
1045854000939	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
1045854000940	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1045854000941	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489
1045854000942	generic binding surface II; other site
1045854000943	generic binding surface I; other site
1045854000944	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
1045854000945	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1045854000946	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1045854000947	homodimer interface [polypeptide binding]; other site
1045854000948	NADP binding site [chemical binding]; other site
1045854000949	substrate binding site [chemical binding]; other site
1045854000950	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1045854000951	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854000952	ATP binding site [chemical binding]; other site
1045854000953	putative Mg++ binding site [ion binding]; other site
1045854000954	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1045854000955	nucleotide binding region [chemical binding]; other site
1045854000956	ATP-binding site [chemical binding]; other site
1045854000957	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1045854000958	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854000959	TRAM domain; Region: TRAM; cl01282
1045854000960	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1045854000961	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
1045854000962	S-adenosylmethionine binding site [chemical binding]; other site
1045854000963	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
1045854000964	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1045854000965	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1045854000966	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1045854000967	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1045854000968	active site
1045854000969	HIGH motif; other site
1045854000970	nucleotide binding site [chemical binding]; other site
1045854000971	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1045854000972	active site
1045854000973	KMSKS motif; other site
1045854000974	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1045854000975	tRNA binding surface [nucleotide binding]; other site
1045854000976	anticodon binding site; other site
1045854000977	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1045854000978	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
1045854000979	dimer interface [polypeptide binding]; other site
1045854000980	conserved gate region; other site
1045854000981	putative PBP binding loops; other site
1045854000982	ABC-ATPase subunit interface; other site
1045854000983	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
1045854000984	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1045854000985	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
1045854000986	This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea.  This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily.  The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294
1045854000987	Walker A/P-loop; other site
1045854000988	ATP binding site [chemical binding]; other site
1045854000989	Q-loop/lid; other site
1045854000990	ABC transporter signature motif; other site
1045854000991	Walker B; other site
1045854000992	D-loop; other site
1045854000993	H-loop/switch region; other site
1045854000994	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141
1045854000995	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1045854000996	Ligand Binding Site [chemical binding]; other site
1045854000997	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
1045854000998	putative deacylase active site [active]
1045854000999	Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792
1045854001000	recombination factor protein RarA; Reviewed; Region: PRK13342
1045854001001	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
1045854001002	Walker A motif; other site
1045854001003	ATP binding site [chemical binding]; other site
1045854001004	Walker B motif; other site
1045854001005	arginine finger; other site
1045854001006	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1045854001007	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1045854001008	RF3 subfamily.  Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria.  Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169
1045854001009	G1 box; other site
1045854001010	putative GEF interaction site [polypeptide binding]; other site
1045854001011	GTP/Mg2+ binding site [chemical binding]; other site
1045854001012	Switch I region; other site
1045854001013	G2 box; other site
1045854001014	G3 box; other site
1045854001015	Switch II region; other site
1045854001016	G4 box; other site
1045854001017	G5 box; other site
1045854001018	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1045854001019	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1045854001020	Active site [active]
1045854001021	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1045854001022	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854001023	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
1045854001024	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1045854001025	active site
1045854001026	catalytic tetrad [active]
1045854001027	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1045854001028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854001029	putative substrate translocation pore; other site
1045854001030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854001031	L-arabinose isomerase; Provisional; Region: PRK02929
1045854001032	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of...; Region: L-fuc_L-ara-isomerases; cl00947
1045854001033	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1045854001034	trimer interface [polypeptide binding]; other site
1045854001035	substrate binding site [chemical binding]; other site
1045854001036	Mn binding site [ion binding]; other site
1045854001037	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cd00398
1045854001038	intersubunit interface [polypeptide binding]; other site
1045854001039	active site
1045854001040	Zn2+ binding site [ion binding]; other site
1045854001041	L-ribulokinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
1045854001042	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1045854001043	putative N- and C-terminal domain interface [polypeptide binding]; other site
1045854001044	putative active site [active]
1045854001045	putative MgATP binding site [chemical binding]; other site
1045854001046	catalytic site [active]
1045854001047	metal binding site [ion binding]; metal-binding site
1045854001048	putative carbohydrate binding site [chemical binding]; other site
1045854001049	galactoside permease; Reviewed; Region: lacY; PRK09528
1045854001050	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854001051	putative substrate translocation pore; other site
1045854001052	Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616
1045854001053	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
1045854001054	active site
1045854001055	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1045854001056	DNA-binding site [nucleotide binding]; DNA binding site
1045854001057	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1045854001058	Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541
1045854001059	putative ligand binding site [chemical binding]; other site
1045854001060	putative dimerization interface [polypeptide binding]; other site
1045854001061	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1045854001062	metal binding site [ion binding]; metal-binding site
1045854001063	active site
1045854001064	I-site; other site
1045854001065	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
1045854001066	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
1045854001067	FemAB family; Region: FemAB; cl11444
1045854001068	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
1045854001069	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
1045854001070	pyruvate kinase; Provisional; Region: PRK05826
1045854001071	domain interfaces; other site
1045854001072	active site
1045854001073	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1045854001074	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854001075	Walker A/P-loop; other site
1045854001076	ATP binding site [chemical binding]; other site
1045854001077	Q-loop/lid; other site
1045854001078	ABC transporter signature motif; other site
1045854001079	Walker B; other site
1045854001080	D-loop; other site
1045854001081	H-loop/switch region; other site
1045854001082	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1045854001083	TM-ABC transporter signature motif; other site
1045854001084	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG2984
1045854001085	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1045854001086	zinc binding site [ion binding]; other site
1045854001087	putative ligand binding site [chemical binding]; other site
1045854001088	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1045854001089	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854001090	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1045854001091	putative substrate translocation pore; other site
1045854001092	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
1045854001093	putative peptidoglycan binding site; other site
1045854001094	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1045854001095	CrcB-like protein; Region: CRCB; cl09114
1045854001096	CrcB-like protein; Region: CRCB; cl09114
1045854001097	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1045854001098	Cation efflux family; Region: Cation_efflux; cl00316
1045854001099	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
1045854001100	putative peptidoglycan binding site; other site
1045854001101	pantothenate kinase; Provisional; Region: PRK05439
1045854001102	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025
1045854001103	ATP-binding site [chemical binding]; other site
1045854001104	CoA-binding site [chemical binding]; other site
1045854001105	Mg2+-binding site [ion binding]; other site
1045854001106	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1045854001107	UvrD/REP helicase; Region: UvrD-helicase; cl14126
1045854001108	Domain of unknown function (DUF956); Region: DUF956; cl01917
1045854001109	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
1045854001110	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
1045854001111	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006
1045854001112	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
1045854001113	active pocket/dimerization site; other site
1045854001114	active site
1045854001115	phosphorylation site [posttranslational modification]
1045854001116	Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cd00001
1045854001117	active site
1045854001118	phosphorylation site [posttranslational modification]
1045854001119	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
1045854001120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854001121	putative substrate translocation pore; other site
1045854001122	CutC family; Region: CutC; cl01218
1045854001123	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1045854001124	conserved hypothetical integral membrane protein; Region: TIGR03766
1045854001125	putative glycosyltransferase TIGR03111; Region: glyc2_xrt_Gpos1
1045854001126	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1045854001127	DXD motif; other site
1045854001128	exosortase family protein; Region: exosort_Gpos; TIGR03110
1045854001129	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides...; Region: GH20_hexosaminidase; cl02948
1045854001130	active site
1045854001131	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
1045854001132	potential frameshift: common BLAST hit: gi|116491922|ref|YP_803657.1| glycosyltransferase
1045854001133	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1045854001134	Sulfatase; Region: Sulfatase; cl10460
1045854001135	Protein of unknown function (DUF1797); Region: DUF1797; cl11550
1045854001136	Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219
1045854001137	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1045854001138	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1045854001139	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-...; Region: GT1_UGDG_like; cd03817
1045854001140	putative ADP-binding pocket [chemical binding]; other site
1045854001141	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1045854001142	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802
1045854001143	active site
1045854001144	substrate binding site [chemical binding]; other site
1045854001145	metal binding site [ion binding]; metal-binding site
1045854001146	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1045854001147	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1045854001148	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1045854001149	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1045854001150	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1045854001151	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1045854001152	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1045854001153	FAD binding domain; Region: FAD_binding_4; pfam01565
1045854001154	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1045854001155	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1045854001156	active site
1045854001157	catalytic site [active]
1045854001158	substrate binding site [chemical binding]; other site
1045854001159	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1045854001160	Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520
1045854001161	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
1045854001162	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1045854001163	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1045854001164	ligand binding site [chemical binding]; other site
1045854001165	active site
1045854001166	UGI interface [polypeptide binding]; other site
1045854001167	catalytic site [active]
1045854001168	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
1045854001169	PspC domain; Region: PspC; cl00864
1045854001170	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854001171	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1045854001172	metal binding site 2 [ion binding]; metal-binding site
1045854001173	putative DNA binding helix; other site
1045854001174	metal binding site 1 [ion binding]; metal-binding site
1045854001175	dimer interface [polypeptide binding]; other site
1045854001176	structural Zn2+ binding site [ion binding]; other site
1045854001177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
1045854001178	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
1045854001179	Walker A motif; other site
1045854001180	ATP binding site [chemical binding]; other site
1045854001181	Walker B motif; other site
1045854001182	Uncharacterized conserved protein [Function unknown]; Region: COG3410
1045854001183	putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151
1045854001184	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730
1045854001185	FMN binding site [chemical binding]; other site
1045854001186	substrate binding site [chemical binding]; other site
1045854001187	putative catalytic residue [active]
1045854001188	acetoin reductase; Validated; Region: PRK08643
1045854001189	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
1045854001190	NAD binding site [chemical binding]; other site
1045854001191	homotetramer interface [polypeptide binding]; other site
1045854001192	homodimer interface [polypeptide binding]; other site
1045854001193	active site
1045854001194	substrate binding site [chemical binding]; other site
1045854001195	Glycerate kinase family; Region: Gly_kinase; cl00841
1045854001196	methionine aminopeptidase; Reviewed; Region: PRK07281
1045854001197	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1045854001198	active site
1045854001199	Predicted transcriptional regulator [Transcription]; Region: COG2378
1045854001200	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1045854001201	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1045854001202	DNA binding residues [nucleotide binding]
1045854001203	putative dimer interface [polypeptide binding]; other site
1045854001204	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
1045854001205	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1045854001206	active site
1045854001207	catalytic tetrad [active]
1045854001208	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854001209	NAD(P) binding site [chemical binding]; other site
1045854001210	active site
1045854001211	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1045854001212	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854001213	putative substrate translocation pore; other site
1045854001214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854001215	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
1045854001216	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1045854001217	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
1045854001218	Walker A/P-loop; other site
1045854001219	ATP binding site [chemical binding]; other site
1045854001220	Q-loop/lid; other site
1045854001221	ABC transporter signature motif; other site
1045854001222	Walker B; other site
1045854001223	D-loop; other site
1045854001224	H-loop/switch region; other site
1045854001225	FtsX-like permease family; Region: FtsX; pfam02687
1045854001226	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
1045854001227	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
1045854001228	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
1045854001229	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1045854001230	replicative DNA helicase; Region: DnaB; TIGR00665
1045854001231	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1045854001232	Walker A motif; other site
1045854001233	ATP binding site [chemical binding]; other site
1045854001234	Walker B motif; other site
1045854001235	DNA binding loops [nucleotide binding]
1045854001236	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1045854001237	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1045854001238	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1045854001239	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1045854001240	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1045854001241	DHH family; Region: DHH; pfam01368
1045854001242	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
1045854001243	dimer interface [polypeptide binding]; other site
1045854001244	conserved gate region; other site
1045854001245	putative PBP binding loops; other site
1045854001246	ABC-ATPase subunit interface; other site
1045854001247	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1045854001248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
1045854001249	dimer interface [polypeptide binding]; other site
1045854001250	conserved gate region; other site
1045854001251	putative PBP binding loops; other site
1045854001252	ABC-ATPase subunit interface; other site
1045854001253	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1045854001254	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
1045854001255	substrate binding pocket [chemical binding]; other site
1045854001256	membrane-bound complex binding site; other site
1045854001257	hinge residues; other site
1045854001258	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1045854001259	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262
1045854001260	Walker A/P-loop; other site
1045854001261	ATP binding site [chemical binding]; other site
1045854001262	Q-loop/lid; other site
1045854001263	ABC transporter signature motif; other site
1045854001264	Walker B; other site
1045854001265	D-loop; other site
1045854001266	H-loop/switch region; other site
1045854001267	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1045854001268	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071
1045854001269	catalytic site [active]
1045854001270	G-X2-G-X-G-K; other site
1045854001271	dipeptidase PepV; Reviewed; Region: PRK07318
1045854001272	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1045854001273	active site
1045854001274	metal binding site [ion binding]; metal-binding site
1045854001275	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
1045854001276	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1045854001277	Walker A/P-loop; other site
1045854001278	ATP binding site [chemical binding]; other site
1045854001279	Q-loop/lid; other site
1045854001280	ABC transporter signature motif; other site
1045854001281	Walker B; other site
1045854001282	D-loop; other site
1045854001283	H-loop/switch region; other site
1045854001284	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1045854001285	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1045854001286	FtsX-like permease family; Region: FtsX; pfam02687
1045854001287	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1045854001288	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
1045854001289	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854001290	Walker A/P-loop; other site
1045854001291	ATP binding site [chemical binding]; other site
1045854001292	Q-loop/lid; other site
1045854001293	ABC transporter signature motif; other site
1045854001294	Walker B; other site
1045854001295	D-loop; other site
1045854001296	H-loop/switch region; other site
1045854001297	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1045854001298	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
1045854001299	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854001300	Walker A/P-loop; other site
1045854001301	ATP binding site [chemical binding]; other site
1045854001302	Q-loop/lid; other site
1045854001303	ABC transporter signature motif; other site
1045854001304	Walker B; other site
1045854001305	D-loop; other site
1045854001306	H-loop/switch region; other site
1045854001307	GTPases [General function prediction only]; Region: HflX; COG2262
1045854001308	HflX subfamily.  A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily.  The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878
1045854001309	G1 box; other site
1045854001310	GTP/Mg2+ binding site [chemical binding]; other site
1045854001311	Switch I region; other site
1045854001312	G2 box; other site
1045854001313	G3 box; other site
1045854001314	Switch II region; other site
1045854001315	G4 box; other site
1045854001316	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
1045854001317	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1045854001318	catalytic core [active]
1045854001319	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1045854001320	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1045854001321	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854001322	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
1045854001323	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1045854001324	substrate binding site [chemical binding]; other site
1045854001325	ATP binding site [chemical binding]; other site
1045854001326	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1045854001327	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1045854001328	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1045854001329	DNA binding site [nucleotide binding]
1045854001330	domain linker motif; other site
1045854001331	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
1045854001332	putative dimerization interface [polypeptide binding]; other site
1045854001333	putative ligand binding site [chemical binding]; other site
1045854001334	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
1045854001335	active site
1045854001336	DNA binding site [nucleotide binding]
1045854001337	putative phosphate binding site [ion binding]; other site
1045854001338	putative catalytic site [active]
1045854001339	metal binding site A [ion binding]; metal-binding site
1045854001340	AP binding site [nucleotide binding]; other site
1045854001341	metal binding site B [ion binding]; metal-binding site
1045854001342	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
1045854001343	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1045854001344	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854001345	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1045854001346	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
1045854001347	rod shape-determining protein MreB; Provisional; Region: PRK13930
1045854001348	Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528
1045854001349	ATP binding site [chemical binding]; other site
1045854001350	profilin binding site; other site
1045854001351	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1045854001352	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1045854001353	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1045854001354	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1045854001355	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1045854001356	active site
1045854001357	metal binding site [ion binding]; metal-binding site
1045854001358	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1045854001359	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
1045854001360	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564
1045854001361	thiamine phosphate binding site [chemical binding]; other site
1045854001362	active site
1045854001363	pyrophosphate binding site [ion binding]; other site
1045854001364	bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427
1045854001365	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1045854001366	dimer interface [polypeptide binding]; other site
1045854001367	substrate binding site [chemical binding]; other site
1045854001368	ATP binding site [chemical binding]; other site
1045854001369	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1045854001370	substrate binding site [chemical binding]; other site
1045854001371	multimerization interface [polypeptide binding]; other site
1045854001372	ATP binding site [chemical binding]; other site
1045854001373	Predicted membrane protein [Function unknown]; Region: COG1511
1045854001374	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1045854001375	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1045854001376	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1045854001377	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
1045854001378	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
1045854001379	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1045854001380	domain; Region: Glyco_hydro_2; pfam00703
1045854001381	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
1045854001382	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1045854001383	catalytic core [active]
1045854001384	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1045854001385	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1045854001386	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854001387	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854001388	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1045854001389	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1045854001390	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1045854001391	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854001392	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
1045854001393	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1045854001394	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
1045854001395	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
1045854001396	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
1045854001397	FemAB family; Region: FemAB; cl11444
1045854001398	peptide chain release factor 2; Provisional; Region: PRK05589
1045854001399	RF-1 domain; Region: RF-1; cl02875
1045854001400	RF-1 domain; Region: RF-1; cl02875
1045854001401	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1045854001402	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
1045854001403	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1045854001404	nucleotide binding region [chemical binding]; other site
1045854001405	ATP-binding site [chemical binding]; other site
1045854001406	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1045854001407	putative substrate binding site [chemical binding]; other site
1045854001408	putative ATP binding site [chemical binding]; other site
1045854001409	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1045854001410	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1045854001411	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1045854001412	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1045854001413	active site
1045854001414	HIGH motif; other site
1045854001415	dimer interface [polypeptide binding]; other site
1045854001416	KMSKS motif; other site
1045854001417	PemK-like protein; Region: PemK; cl00995
1045854001418	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
1045854001419	alanine racemase; Reviewed; Region: alr; PRK00053
1045854001420	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1045854001421	active site
1045854001422	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1045854001423	dimer interface [polypeptide binding]; other site
1045854001424	substrate binding site [chemical binding]; other site
1045854001425	catalytic residues [active]
1045854001426	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif (...; Region: DEADc; cd00268
1045854001427	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1045854001428	ATP binding site [chemical binding]; other site
1045854001429	Mg++ binding site [ion binding]; other site
1045854001430	motif III; other site
1045854001431	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1045854001432	nucleotide binding region [chemical binding]; other site
1045854001433	ATP-binding site [chemical binding]; other site
1045854001434	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369
1045854001435	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1045854001436	hinge; other site
1045854001437	active site
1045854001438	CTP synthetase; Validated; Region: pyrG; PRK05380
1045854001439	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113
1045854001440	Catalytic site [active]
1045854001441	Active site [active]
1045854001442	UTP binding site [chemical binding]; other site
1045854001443	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1045854001444	active site
1045854001445	putative oxyanion hole; other site
1045854001446	catalytic triad [active]
1045854001447	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319
1045854001448	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1045854001449	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1045854001450	NADP binding site [chemical binding]; other site
1045854001451	active site
1045854001452	putative substrate binding site [chemical binding]; other site
1045854001453	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1045854001454	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1045854001455	NAD binding site [chemical binding]; other site
1045854001456	substrate binding site [chemical binding]; other site
1045854001457	homodimer interface [polypeptide binding]; other site
1045854001458	active site
1045854001459	Cupin domain; Region: Cupin_2; cl09118
1045854001460	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1045854001461	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1045854001462	substrate binding site [chemical binding]; other site
1045854001463	tetramer interface [polypeptide binding]; other site
1045854001464	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1045854001465	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1045854001466	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
1045854001467	Probable Catalytic site [active]
1045854001468	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1045854001469	Domain of unknown function (DUF74); Region: DUF74; cl00426
1045854001470	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
1045854001471	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1045854001472	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1045854001473	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1045854001474	Zn2+ binding site [ion binding]; other site
1045854001475	Mg2+ binding site [ion binding]; other site
1045854001476	Domain of unknown function (DUF1934); Region: DUF1934; cl01870
1045854001477	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149
1045854001478	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987
1045854001479	protein binding site [polypeptide binding]; other site
1045854001480	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1045854001481	YycH protein; Region: YycI; cl02015
1045854001482	YycH protein; Region: YycH; pfam07435
1045854001483	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1045854001484	Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225
1045854001485	dimerization interface [polypeptide binding]; other site
1045854001486	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1045854001487	putative active site [active]
1045854001488	heme pocket [chemical binding]; other site
1045854001489	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
1045854001490	dimer interface [polypeptide binding]; other site
1045854001491	phosphorylation site [posttranslational modification]
1045854001492	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1045854001493	ATP binding site [chemical binding]; other site
1045854001494	Mg2+ binding site [ion binding]; other site
1045854001495	G-X-G motif; other site
1045854001496	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1045854001497	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
1045854001498	active site
1045854001499	phosphorylation site [posttranslational modification]
1045854001500	intermolecular recognition site; other site
1045854001501	dimerization interface [polypeptide binding]; other site
1045854001502	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
1045854001503	DNA binding site [nucleotide binding]
1045854001504	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
1045854001505	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1045854001506	ssDNA binding site [nucleotide binding]; other site
1045854001507	dimer interface [polypeptide binding]; other site
1045854001508	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1045854001509	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
1045854001510	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
1045854001511	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
1045854001512	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1045854001513	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1045854001514	Substrate binding site [chemical binding]; other site
1045854001515	Mg++ binding site [ion binding]; other site
1045854001516	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1045854001517	active site
1045854001518	substrate binding site [chemical binding]; other site
1045854001519	CoA binding site [chemical binding]; other site
1045854001520	pur operon repressor; Provisional; Region: PRK09213
1045854001521	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1045854001522	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
1045854001523	glycerol kinase; Provisional; Region: glpK; PRK00047
1045854001524	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1045854001525	N- and C-terminal domain interface [polypeptide binding]; other site
1045854001526	active site
1045854001527	MgATP binding site [chemical binding]; other site
1045854001528	catalytic site [active]
1045854001529	metal binding site [ion binding]; metal-binding site
1045854001530	glycerol binding site [chemical binding]; other site
1045854001531	homotetramer interface [polypeptide binding]; other site
1045854001532	homodimer interface [polypeptide binding]; other site
1045854001533	FBP binding site [chemical binding]; other site
1045854001534	protein IIAGlc interface [polypeptide binding]; other site
1045854001535	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1045854001536	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1045854001537	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1045854001538	helicase-exonuclease AddAB, AddA subunit; Region: addA_Gpos; TIGR02785
1045854001539	UvrD/REP helicase; Region: UvrD-helicase; cl14126
1045854001540	UvrD/REP helicase; Region: UvrD-helicase; cl14126
1045854001541	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1045854001542	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1045854001543	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1045854001544	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1045854001545	nucleoside/Zn binding site; other site
1045854001546	dimer interface [polypeptide binding]; other site
1045854001547	catalytic motif [active]
1045854001548	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
1045854001549	S-adenosylmethionine binding site [chemical binding]; other site
1045854001550	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1045854001551	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1045854001552	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1045854001553	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
1045854001554	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1045854001555	NAD binding site [chemical binding]; other site
1045854001556	substrate binding site [chemical binding]; other site
1045854001557	catalytic Zn binding site [ion binding]; other site
1045854001558	tetramer interface [polypeptide binding]; other site
1045854001559	structural Zn binding site [ion binding]; other site
1045854001560	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
1045854001561	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1045854001562	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1045854001563	alphaNTD - beta interaction site [polypeptide binding]; other site
1045854001564	alphaNTD homodimer interface [polypeptide binding]; other site
1045854001565	alphaNTD - beta' interaction site [polypeptide binding]; other site
1045854001566	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
1045854001567	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
1045854001568	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
1045854001569	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
1045854001570	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
1045854001571	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1045854001572	rRNA binding site [nucleotide binding]; other site
1045854001573	predicted 30S ribosome binding site; other site
1045854001574	adenylate kinase; Reviewed; Region: adk; PRK00279
1045854001575	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1045854001576	AMP-binding site [chemical binding]; other site
1045854001577	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1045854001578	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1045854001579	SecY translocase; Region: SecY; pfam00344
1045854001580	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
1045854001581	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658
1045854001582	23S rRNA binding site [nucleotide binding]; other site
1045854001583	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1045854001584	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1045854001585	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1045854001586	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1045854001587	5S rRNA interface [nucleotide binding]; other site
1045854001588	L27 interface [polypeptide binding]; other site
1045854001589	23S rRNA interface [nucleotide binding]; other site
1045854001590	L5 interface [polypeptide binding]; other site
1045854001591	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1045854001592	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1045854001593	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1045854001594	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
1045854001595	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1045854001596	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1045854001597	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1045854001598	KOW motif; Region: KOW; cl00354
1045854001599	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
1045854001600	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
1045854001601	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427
1045854001602	23S rRNA interface [nucleotide binding]; other site
1045854001603	putative translocon interaction site; other site
1045854001604	signal recognition particle (SRP54) interaction site; other site
1045854001605	L23 interface [polypeptide binding]; other site
1045854001606	trigger factor interaction site; other site
1045854001607	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1045854001608	23S rRNA interface [nucleotide binding]; other site
1045854001609	5S rRNA interface [nucleotide binding]; other site
1045854001610	putative antibiotic binding site [chemical binding]; other site
1045854001611	L25 interface [polypeptide binding]; other site
1045854001612	L27 interface [polypeptide binding]; other site
1045854001613	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1045854001614	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The...; Region: 30S_S3_KH; cd02412
1045854001615	G-X-X-G motif; other site
1045854001616	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1045854001617	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1045854001618	putative translocon binding site; other site
1045854001619	protein-rRNA interface [nucleotide binding]; other site
1045854001620	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
1045854001621	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1045854001622	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1045854001623	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1045854001624	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
1045854001625	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
1045854001626	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
1045854001627	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
1045854001628	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1045854001629	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
1045854001630	FkbH-like domain; Region: FkbH; TIGR01686
1045854001631	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
1045854001632	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1045854001633	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (; Region: GT1_wlbH_like; cd03798
1045854001634	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1045854001635	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1045854001636	MatE; Region: MatE; cl10513
1045854001637	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1045854001638	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647
1045854001639	trimer interface [polypeptide binding]; other site
1045854001640	CoA binding site [chemical binding]; other site
1045854001641	active site
1045854001642	Chain length determinant protein; Region: Wzz; cl01623
1045854001643	Bacterial sugar transferase; Region: Bac_transf; cl00939
1045854001644	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1045854001645	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1045854001646	catalytic residues [active]
1045854001647	catalytic nucleophile [active]
1045854001648	Presynaptic Site I dimer interface [polypeptide binding]; other site
1045854001649	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1045854001650	Synaptic Flat tetramer interface [polypeptide binding]; other site
1045854001651	Synaptic Site I dimer interface [polypeptide binding]; other site
1045854001652	DNA binding site [nucleotide binding]
1045854001653	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
1045854001654	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1045854001655	active site
1045854001656	homodimer interface [polypeptide binding]; other site
1045854001657	UGMP family protein; Validated; Region: PRK09604
1045854001658	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
1045854001659	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1045854001660	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1045854001661	Coenzyme A binding pocket [chemical binding]; other site
1045854001662	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1045854001663	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1045854001664	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1045854001665	Coenzyme A binding pocket [chemical binding]; other site
1045854001666	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
1045854001667	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004
1045854001668	active site
1045854001669	catalytic site [active]
1045854001670	Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557
1045854001671	D-lactate dehydrogenase; Validated; Region: PRK08605
1045854001672	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854001673	D-lactate dehydrogenase; Validated; Region: PRK08605
1045854001674	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854001675	seryl-tRNA synthetase; Provisional; Region: PRK05431
1045854001676	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1045854001677	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1045854001678	dimer interface [polypeptide binding]; other site
1045854001679	active site
1045854001680	motif 1; other site
1045854001681	motif 2; other site
1045854001682	motif 3; other site
1045854001683	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1045854001684	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673
1045854001685	Substrate-binding site [chemical binding]; other site
1045854001686	Substrate specificity [chemical binding]; other site
1045854001687	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1045854001688	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
1045854001689	ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401
1045854001690	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1045854001691	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
1045854001692	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1045854001693	alpha subunit interaction interface [polypeptide binding]; other site
1045854001694	Walker A motif; other site
1045854001695	ATP binding site [chemical binding]; other site
1045854001696	Walker B motif; other site
1045854001697	inhibitor binding site; inhibition site
1045854001698	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1045854001699	ATP synthase; Region: ATP-synt; cl00365
1045854001700	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1045854001701	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
1045854001702	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1045854001703	beta subunit interaction interface [polypeptide binding]; other site
1045854001704	Walker A motif; other site
1045854001705	ATP binding site [chemical binding]; other site
1045854001706	Walker B motif; other site
1045854001707	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1045854001708	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
1045854001709	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1045854001710	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
1045854001711	ATP synthase subunit C; Region: ATP-synt_C; cl00466
1045854001712	ATP synthase A chain; Region: ATP-synt_A; cl00413
1045854001713	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
1045854001714	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1045854001715	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378
1045854001716	dimer interface [polypeptide binding]; other site
1045854001717	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1045854001718	active site
1045854001719	folate binding site [chemical binding]; other site
1045854001720	yrdC domain; Region: Sua5_yciO_yrdC; cl00305
1045854001721	SUA5 domain; Region: SUA5; pfam03481
1045854001722	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1045854001723	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
1045854001724	S-adenosylmethionine binding site [chemical binding]; other site
1045854001725	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1045854001726	RF-1 domain; Region: RF-1; cl02875
1045854001727	RF-1 domain; Region: RF-1; cl02875
1045854001728	Thymidine kinase; Region: TK; cl00631
1045854001729	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1045854001730	catalytic triad [active]
1045854001731	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1045854001732	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1045854001733	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1045854001734	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
1045854001735	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
1045854001736	active site
1045854001737	Zn binding site [ion binding]; other site
1045854001738	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
1045854001739	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1045854001740	non-specific DNA binding site [nucleotide binding]; other site
1045854001741	salt bridge; other site
1045854001742	sequence-specific DNA binding site [nucleotide binding]; other site
1045854001743	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1045854001744	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
1045854001745	S-adenosylmethionine binding site [chemical binding]; other site
1045854001746	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1045854001747	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
1045854001748	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854001749	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1045854001750	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1045854001751	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
1045854001752	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1045854001753	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1045854001754	MatE; Region: MatE; cl10513
1045854001755	MatE; Region: MatE; cl10513
1045854001756	Beta-lactamase; Region: Beta-lactamase; cl01009
1045854001757	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1045854001758	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1045854001759	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1045854001760	HIGH motif; other site
1045854001761	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1045854001762	active site
1045854001763	KMSKS motif; other site
1045854001764	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1045854001765	tRNA binding surface [nucleotide binding]; other site
1045854001766	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1045854001767	active site
1045854001768	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1045854001769	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
1045854001770	S-adenosylmethionine binding site [chemical binding]; other site
1045854001771	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1045854001772	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
1045854001773	Peptidase family C69; Region: Peptidase_C69; cl01920
1045854001774	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1045854001775	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
1045854001776	LytTr DNA-binding domain; Region: LytTR; cl04498
1045854001777	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base...; Region: nuc_hydro_TvIAG; cd02647
1045854001778	active site
1045854001779	dimerization interface [polypeptide binding]; other site
1045854001780	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1045854001781	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
1045854001782	Walker A/P-loop; other site
1045854001783	ATP binding site [chemical binding]; other site
1045854001784	Q-loop/lid; other site
1045854001785	ABC transporter signature motif; other site
1045854001786	Walker B; other site
1045854001787	D-loop; other site
1045854001788	H-loop/switch region; other site
1045854001789	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1045854001790	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1045854001791	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1045854001792	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1045854001793	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1045854001794	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
1045854001795	Response regulator receiver domain; Region: Response_reg; pfam00072
1045854001796	active site
1045854001797	phosphorylation site [posttranslational modification]
1045854001798	intermolecular recognition site; other site
1045854001799	dimerization interface [polypeptide binding]; other site
1045854001800	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1045854001801	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1045854001802	ATP binding site [chemical binding]; other site
1045854001803	Mg2+ binding site [ion binding]; other site
1045854001804	G-X-G motif; other site
1045854001805	Predicted membrane protein [Function unknown]; Region: COG1288
1045854001806	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
1045854001807	Sugar transport protein; Region: Sugar_transport; pfam06800
1045854001808	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
1045854001809	pfkB family carbohydrate kinase; Region: PfkB; pfam00294
1045854001810	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174
1045854001811	substrate binding site [chemical binding]; other site
1045854001812	dimer interface [polypeptide binding]; other site
1045854001813	ATP binding site [chemical binding]; other site
1045854001814	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
1045854001815	transmembrane helices; other site
1045854001816	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161
1045854001817	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1045854001818	Protein of unknown function (DUF419); Region: DUF419; cl15265
1045854001819	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1045854001820	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854001821	Walker A/P-loop; other site
1045854001822	ATP binding site [chemical binding]; other site
1045854001823	Q-loop/lid; other site
1045854001824	ABC transporter signature motif; other site
1045854001825	Walker B; other site
1045854001826	D-loop; other site
1045854001827	H-loop/switch region; other site
1045854001828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
1045854001829	dimer interface [polypeptide binding]; other site
1045854001830	conserved gate region; other site
1045854001831	ABC-ATPase subunit interface; other site
1045854001832	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
1045854001833	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1045854001834	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854001835	Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243
1045854001836	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1045854001837	putative NAD(P) binding site [chemical binding]; other site
1045854001838	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1045854001839	peripheral dimer interface [polypeptide binding]; other site
1045854001840	core dimer interface [polypeptide binding]; other site
1045854001841	L10 interface [polypeptide binding]; other site
1045854001842	L11 interface [polypeptide binding]; other site
1045854001843	putative EF-Tu interaction site [polypeptide binding]; other site
1045854001844	putative EF-G interaction site [polypeptide binding]; other site
1045854001845	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797
1045854001846	23S rRNA interface [nucleotide binding]; other site
1045854001847	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1045854001848	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403
1045854001849	mRNA/rRNA interface [nucleotide binding]; other site
1045854001850	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1045854001851	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1045854001852	23S rRNA interface [nucleotide binding]; other site
1045854001853	L7/L12 interface [polypeptide binding]; other site
1045854001854	putative thiostrepton binding site; other site
1045854001855	L25 interface [polypeptide binding]; other site
1045854001856	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1045854001857	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1045854001858	putative homodimer interface [polypeptide binding]; other site
1045854001859	KOW motif; Region: KOW; cl00354
1045854001860	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
1045854001861	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
1045854001862	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1045854001863	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
1045854001864	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1045854001865	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
1045854001866	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
1045854001867	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cl00258
1045854001868	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1045854001869	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1045854001870	active site
1045854001871	HIGH motif; other site
1045854001872	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1045854001873	KMSKS motif; other site
1045854001874	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1045854001875	tRNA binding surface [nucleotide binding]; other site
1045854001876	anticodon binding site; other site
1045854001877	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1045854001878	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553
1045854001879	homodimer interface [polypeptide binding]; other site
1045854001880	NAD binding pocket [chemical binding]; other site
1045854001881	ATP binding pocket [chemical binding]; other site
1045854001882	Mg binding site [ion binding]; other site
1045854001883	active-site loop [active]
1045854001884	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1045854001885	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570
1045854001886	active site
1045854001887	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
1045854001888	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260
1045854001889	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1045854001890	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258
1045854001891	Walker A/P-loop; other site
1045854001892	ATP binding site [chemical binding]; other site
1045854001893	Q-loop/lid; other site
1045854001894	ABC transporter signature motif; other site
1045854001895	Walker B; other site
1045854001896	D-loop; other site
1045854001897	H-loop/switch region; other site
1045854001898	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
1045854001899	dimer interface [polypeptide binding]; other site
1045854001900	conserved gate region; other site
1045854001901	putative PBP binding loops; other site
1045854001902	ABC-ATPase subunit interface; other site
1045854001903	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
1045854001904	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1045854001905	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1045854001906	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002
1045854001907	putative deacylase active site [active]
1045854001908	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1045854001909	Haemolysin-III related; Region: HlyIII; cl03831
1045854001910	putative phosphoketolase; Provisional; Region: PRK05261
1045854001911	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629
1045854001912	TPP-binding site [chemical binding]; other site
1045854001913	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
1045854001914	XFP C-terminal domain; Region: XFP_C; pfam09363
1045854001915	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
1045854001916	Sodium:solute symporter family; Region: SSF; cl00456
1045854001917	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1045854001918	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1045854001919	DNA-binding site [nucleotide binding]; DNA binding site
1045854001920	UTRA domain; Region: UTRA; cl01230
1045854001921	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854001922	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1045854001923	putative substrate translocation pore; other site
1045854001924	conserved hypothetical integral membrane protein; Region: TIGR03766
1045854001925	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
1045854001926	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
1045854001927	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
1045854001928	putative Ca2+ binding sites [ion binding]; other site
1045854001929	domain interaction interfaces; other site
1045854001930	putative ligand binding motif; other site
1045854001931	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
1045854001932	putative Ca2+ binding sites [ion binding]; other site
1045854001933	domain interaction interfaces; other site
1045854001934	putative ligand binding motif; other site
1045854001935	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
1045854001936	putative Ca2+ binding sites [ion binding]; other site
1045854001937	domain interaction interfaces; other site
1045854001938	putative ligand binding motif; other site
1045854001939	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
1045854001940	putative Ca2+ binding sites [ion binding]; other site
1045854001941	domain interaction interfaces; other site
1045854001942	putative ligand binding motif; other site
1045854001943	MAEBL; Provisional; Region: PTZ00121
1045854001944	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1045854001945	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854001946	Walker A/P-loop; other site
1045854001947	ATP binding site [chemical binding]; other site
1045854001948	Q-loop/lid; other site
1045854001949	ABC transporter signature motif; other site
1045854001950	Walker B; other site
1045854001951	D-loop; other site
1045854001952	H-loop/switch region; other site
1045854001953	ABC transporter; Region: ABC_tran_2; pfam12848
1045854001954	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
1045854001955	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550
1045854001956	ABC-ATPase subunit  interface; other site
1045854001957	dimer interface [polypeptide binding]; other site
1045854001958	putative PBP binding regions; other site
1045854001959	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1045854001960	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854001961	Walker A/P-loop; other site
1045854001962	ATP binding site [chemical binding]; other site
1045854001963	Q-loop/lid; other site
1045854001964	ABC transporter signature motif; other site
1045854001965	Walker B; other site
1045854001966	D-loop; other site
1045854001967	H-loop/switch region; other site
1045854001968	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262
1045854001969	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1045854001970	intersubunit interface [polypeptide binding]; other site
1045854001971	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854001972	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1045854001973	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1045854001974	catalytic triad [active]
1045854001975	catalytic triad [active]
1045854001976	oxyanion hole [active]
1045854001977	Protein of unknown function (DUF975); Region: DUF975; cl10504
1045854001978	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1045854001979	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
1045854001980	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1045854001981	DNA binding residues [nucleotide binding]
1045854001982	putative dimer interface [polypeptide binding]; other site
1045854001983	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1045854001984	classical (c) SDRs; Region: SDR_c; cd05233
1045854001985	NAD(P) binding site [chemical binding]; other site
1045854001986	active site
1045854001987	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1045854001988	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1045854001989	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1045854001990	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
1045854001991	dimer interface [polypeptide binding]; other site
1045854001992	phosphorylation site [posttranslational modification]
1045854001993	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1045854001994	ATP binding site [chemical binding]; other site
1045854001995	Mg2+ binding site [ion binding]; other site
1045854001996	G-X-G motif; other site
1045854001997	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1045854001998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
1045854001999	active site
1045854002000	phosphorylation site [posttranslational modification]
1045854002001	intermolecular recognition site; other site
1045854002002	dimerization interface [polypeptide binding]; other site
1045854002003	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
1045854002004	DNA binding site [nucleotide binding]
1045854002005	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
1045854002006	GTP-binding protein YchF; Reviewed; Region: PRK09601
1045854002007	YchF subfamily.  YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1.  Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900
1045854002008	G1 box; other site
1045854002009	GTP/Mg2+ binding site [chemical binding]; other site
1045854002010	Switch I region; other site
1045854002011	G2 box; other site
1045854002012	Switch II region; other site
1045854002013	G3 box; other site
1045854002014	G4 box; other site
1045854002015	G5 box; other site
1045854002016	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1045854002017	Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864
1045854002018	ParB-like nuclease domain; Region: ParBc; cl02129
1045854002019	ParB-like partition proteins; Region: parB_part; TIGR00180
1045854002020	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1045854002021	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
1045854002022	P-loop; other site
1045854002023	Magnesium ion binding site [ion binding]; other site
1045854002024	Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444
1045854002025	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042
1045854002026	Magnesium ion binding site [ion binding]; other site
1045854002027	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1045854002028	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
1045854002029	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1045854002030	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801
1045854002031	FMN binding site [chemical binding]; other site
1045854002032	active site
1045854002033	catalytic residues [active]
1045854002034	substrate binding site [chemical binding]; other site
1045854002035	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1045854002036	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1045854002037	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1045854002038	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1045854002039	Domain of unknown function DUF20; Region: UPF0118; cl00465
1045854002040	Acylphosphatase; Region: Acylphosphatase; cl00551
1045854002041	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1045854002042	substrate binding site [chemical binding]; other site
1045854002043	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1045854002044	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1045854002045	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
1045854002046	classical (c) SDRs; Region: SDR_c; cd05233
1045854002047	NAD(P) binding site [chemical binding]; other site
1045854002048	active site
1045854002049	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1045854002050	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1045854002051	DNA binding residues [nucleotide binding]
1045854002052	putative dimer interface [polypeptide binding]; other site
1045854002053	TRAM domain; Region: TRAM; cl01282
1045854002054	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
1045854002055	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
1045854002056	Protein of unknown function (DUF1393); Region: DUF1393; cl01942
1045854002057	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1045854002058	GMP synthase; Reviewed; Region: guaA; PRK00074
1045854002059	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1045854002060	AMP/PPi binding site [chemical binding]; other site
1045854002061	candidate oxyanion hole; other site
1045854002062	catalytic triad [active]
1045854002063	potential glutamine specificity residues [chemical binding]; other site
1045854002064	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1045854002065	ATP Binding subdomain [chemical binding]; other site
1045854002066	Dimerization subdomain; other site
1045854002067	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-...; Region: ClC_like; cd01033
1045854002068	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
1045854002069	putative ion selectivity filter; other site
1045854002070	putative pore gating glutamate residue; other site
1045854002071	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1045854002072	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1045854002073	NADP binding site [chemical binding]; other site
1045854002074	Predicted transcriptional regulator [Transcription]; Region: COG1959
1045854002075	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854002076	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854002077	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1045854002078	putative substrate translocation pore; other site
1045854002079	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1045854002080	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854002081	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
1045854002082	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
1045854002083	metal binding site [ion binding]; metal-binding site
1045854002084	dimer interface [polypeptide binding]; other site
1045854002085	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
1045854002086	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1045854002087	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
1045854002088	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854002089	NAD(P) binding site [chemical binding]; other site
1045854002090	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1045854002091	active site
1045854002092	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
1045854002093	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
1045854002094	active site
1045854002095	catalytic tetrad [active]
1045854002096	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1045854002097	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1045854002098	RNA/DNA hybrid binding site [nucleotide binding]; other site
1045854002099	active site
1045854002100	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1045854002101	Cation transport protein; Region: TrkH; cl10514
1045854002102	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1045854002103	Cation transport protein; Region: TrkH; cl10514
1045854002104	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679
1045854002105	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1045854002106	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1045854002107	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1045854002108	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854002109	Walker A/P-loop; other site
1045854002110	ATP binding site [chemical binding]; other site
1045854002111	Q-loop/lid; other site
1045854002112	ABC transporter signature motif; other site
1045854002113	Walker B; other site
1045854002114	D-loop; other site
1045854002115	H-loop/switch region; other site
1045854002116	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1045854002117	non-specific DNA binding site [nucleotide binding]; other site
1045854002118	salt bridge; other site
1045854002119	sequence-specific DNA binding site [nucleotide binding]; other site
1045854002120	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
1045854002121	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
1045854002122	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1045854002123	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1045854002124	ligand binding site [chemical binding]; other site
1045854002125	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
1045854002126	RelB antitoxin; Region: RelB; cl01171
1045854002127	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1045854002128	non-specific DNA binding site [nucleotide binding]; other site
1045854002129	salt bridge; other site
1045854002130	sequence-specific DNA binding site [nucleotide binding]; other site
1045854002131	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
1045854002132	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1045854002133	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1045854002134	catalytic residues [active]
1045854002135	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1045854002136	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854002137	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854002138	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1045854002139	catalytic residues [active]
1045854002140	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1045854002141	catalytic residues [active]
1045854002142	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1045854002143	catalytic residues [active]
1045854002144	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1045854002145	dimerization interface [polypeptide binding]; other site
1045854002146	putative DNA binding site [nucleotide binding]; other site
1045854002147	putative Zn2+ binding site [ion binding]; other site
1045854002148	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1045854002149	active site residue [active]
1045854002150	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1045854002151	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
1045854002152	ligand binding site [chemical binding]; other site
1045854002153	flexible hinge region; other site
1045854002154	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854002155	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1045854002156	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1045854002157	Protein of unknown function (DUF3533); Region: DUF3533; pfam12051
1045854002158	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1045854002159	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1045854002160	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1045854002161	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1045854002162	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1045854002163	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
1045854002164	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1045854002165	active site
1045854002166	catalytic tetrad [active]
1045854002167	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1045854002168	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854002169	Protein of unknown function, DUF606; Region: DUF606; cl01273
1045854002170	Protein of unknown function, DUF606; Region: DUF606; cl01273
1045854002171	Collagen binding domain; Region: Collagen_bind; pfam05737
1045854002172	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
1045854002173	putative Ca2+ binding sites [ion binding]; other site
1045854002174	domain interaction interfaces; other site
1045854002175	putative ligand binding motif; other site
1045854002176	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
1045854002177	putative Ca2+ binding sites [ion binding]; other site
1045854002178	domain interaction interfaces; other site
1045854002179	putative ligand binding motif; other site
1045854002180	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
1045854002181	domain interaction interfaces; other site
1045854002182	putative Ca2+ binding sites [ion binding]; other site
1045854002183	putative ligand binding motif; other site
1045854002184	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
1045854002185	domain interaction interfaces; other site
1045854002186	putative Ca2+ binding sites [ion binding]; other site
1045854002187	putative ligand binding motif; other site
1045854002188	Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619
1045854002189	domain interaction interfaces; other site
1045854002190	putative Ca2+ binding sites [ion binding]; other site
1045854002191	putative ligand binding motif; other site
1045854002192	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1045854002193	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854002194	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1045854002195	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1045854002196	putative NAD(P) binding site [chemical binding]; other site
1045854002197	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1045854002198	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1045854002199	putative active site [active]
1045854002200	putative FMN binding site [chemical binding]; other site
1045854002201	putative substrate binding site [chemical binding]; other site
1045854002202	putative catalytic residue [active]
1045854002203	Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788
1045854002204	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1045854002205	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1045854002206	DNA binding residues [nucleotide binding]
1045854002207	putative dimer interface [polypeptide binding]; other site
1045854002208	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1045854002209	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854002210	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1045854002211	dimerization interface [polypeptide binding]; other site
1045854002212	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854002213	NmrA-like family; Region: NmrA; pfam05368
1045854002214	NAD(P) binding site [chemical binding]; other site
1045854002215	active site
1045854002216	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
1045854002217	MgtC family; Region: MgtC; cl12207
1045854002218	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1045854002219	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1045854002220	putative NAD(P) binding site [chemical binding]; other site
1045854002221	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1045854002222	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1045854002223	recombination factor protein RarA; Reviewed; Region: PRK13342
1045854002224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
1045854002225	Walker A motif; other site
1045854002226	ATP binding site [chemical binding]; other site
1045854002227	Walker B motif; other site
1045854002228	arginine finger; other site
1045854002229	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1045854002230	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1045854002231	DNA binding residues [nucleotide binding]
1045854002232	GA module; Region: GA; cl08325
1045854002233	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1045854002234	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1045854002235	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1045854002236	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1045854002237	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467
1045854002238	active site
1045854002239	Cupin domain; Region: Cupin_2; cl09118
1045854002240	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1045854002241	Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788
1045854002242	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1045854002243	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854002244	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1045854002245	dimerization interface [polypeptide binding]; other site
1045854002246	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1045854002247	Ligand binding site [chemical binding]; other site
1045854002248	metal binding site [ion binding]; metal-binding site
1045854002249	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1045854002250	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854002251	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110
1045854002252	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
1045854002253	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88)...; Region: Peptidase_S24_S26; cd06462
1045854002254	Catalytic site [active]
1045854002255	Peptidase S26; Region: Peptidase_S26; pfam10502
1045854002256	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1045854002257	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1045854002258	Ribonuclease P; Region: Ribonuclease_P; cl00457
1045854002259	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
1045854002260	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1045854002261	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
1045854002262	Walker A motif; other site
1045854002263	ATP binding site [chemical binding]; other site
1045854002264	Walker B motif; other site
1045854002265	arginine finger; other site
1045854002266	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1045854002267	DnaA box-binding interface [nucleotide binding]; other site
1045854002268	DNA polymerase III subunit beta; Validated; Region: PRK05643
1045854002269	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140
1045854002270	putative DNA binding surface [nucleotide binding]; other site
1045854002271	dimer interface [polypeptide binding]; other site
1045854002272	beta-clamp/clamp loader binding surface; other site
1045854002273	beta-clamp/translesion DNA polymerase binding surface; other site
1045854002274	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1045854002275	recombination protein F; Reviewed; Region: recF; PRK00064
1045854002276	RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage.  When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242
1045854002277	Walker A/P-loop; other site
1045854002278	ATP binding site [chemical binding]; other site
1045854002279	Q-loop/lid; other site
1045854002280	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854002281	ABC transporter signature motif; other site
1045854002282	Walker B; other site
1045854002283	D-loop; other site
1045854002284	H-loop/switch region; other site
1045854002285	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1045854002286	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1045854002287	ATP binding site [chemical binding]; other site
1045854002288	Mg2+ binding site [ion binding]; other site
1045854002289	G-X-G motif; other site
1045854002290	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822
1045854002291	anchoring element; other site
1045854002292	dimer interface [polypeptide binding]; other site
1045854002293	ATP binding site [chemical binding]; other site
1045854002294	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1045854002295	active site
1045854002296	putative metal-binding site [ion binding]; other site
1045854002297	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1045854002298	DNA gyrase subunit A; Validated; Region: PRK05560
1045854002299	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187
1045854002300	CAP-like domain; other site
1045854002301	Active site [active]
1045854002302	primary dimer interface [polypeptide binding]; other site
1045854002303	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1045854002304	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1045854002305	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1045854002306	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1045854002307	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1045854002308	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1045854002309	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1045854002310	Sulfatase; Region: Sulfatase; cl10460
1045854002311	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1045854002312	DNA binding residues [nucleotide binding]
1045854002313	putative dimer interface [polypeptide binding]; other site
1045854002314	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
1045854002315	homodimer interface [polypeptide binding]; other site
1045854002316	NAD binding site [chemical binding]; other site
1045854002317	catalytic residues [active]
1045854002318	substrate binding pocket [chemical binding]; other site
1045854002319	flexible flap; other site
1045854002320	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1045854002321	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1045854002322	active site
1045854002323	HIGH motif; other site
1045854002324	KMSKS motif; other site
1045854002325	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1045854002326	tRNA binding surface [nucleotide binding]; other site
1045854002327	anticodon binding site; other site
1045854002328	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1045854002329	dimer interface [polypeptide binding]; other site
1045854002330	putative tRNA-binding site [nucleotide binding]; other site
1045854002331	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1045854002332	putative deoxyribonuclease YjjV; Provisional; Region: PRK11449
1045854002333	active site
1045854002334	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1045854002335	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in...; Region: TOPRIM_RNase_M5_like; cd01027
1045854002336	putative active site [active]
1045854002337	putative metal binding site [ion binding]; other site
1045854002338	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
1045854002339	S-adenosylmethionine binding site [chemical binding]; other site
1045854002340	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1045854002341	Domain of unknown function DUF21; Region: DUF21; pfam01595
1045854002342	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1045854002343	Transporter associated domain; Region: CorC_HlyC; cl08393
1045854002344	Protein of unknown function (DUF1021); Region: DUF1021; cl01852
1045854002345	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1045854002346	catalytic motif [active]
1045854002347	Zn binding site [ion binding]; other site
1045854002348	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1045854002349	dimerization interface [polypeptide binding]; other site
1045854002350	active site
1045854002351	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1045854002352	Protein of unknown function (DUF1700); Region: DUF1700; cl01933
1045854002353	Bacitracin resistance protein BacA; Region: BacA; cl00858
1045854002354	Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918
1045854002355	Amidinotransferase; Region: Amidinotransf; cl12043
1045854002356	Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235
1045854002357	ornithine carbamoyltransferase; Validated; Region: PRK02102
1045854002358	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1045854002359	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854002360	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
1045854002361	carbamate kinase; Reviewed; Region: PRK12686
1045854002362	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1045854002363	putative substrate binding site [chemical binding]; other site
1045854002364	nucleotide binding site [chemical binding]; other site
1045854002365	nucleotide binding site [chemical binding]; other site
1045854002366	homodimer interface [polypeptide binding]; other site
1045854002367	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
1045854002368	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1045854002369	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1045854002370	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1045854002371	Ligand binding site [chemical binding]; other site
1045854002372	Putative Catalytic site [active]
1045854002373	DXD motif; other site
1045854002374	conserved hypothetical integral membrane protein; Region: TIGR03766
1045854002375	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1045854002376	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1045854002377	Ligand binding site [chemical binding]; other site
1045854002378	Putative Catalytic site [active]
1045854002379	DXD motif; other site
1045854002380	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
1045854002381	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1045854002382	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1045854002383	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
1045854002384	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200
1045854002385	amphipathic channel; other site
1045854002386	Asn-Pro-Ala signature motifs; other site
1045854002387	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1045854002388	tetramer interfaces [polypeptide binding]; other site
1045854002389	binuclear metal-binding site [ion binding]; other site
1045854002390	Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one  highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216
1045854002391	tetramer interface [polypeptide binding]; other site
1045854002392	active site/substrate binding site [active]
1045854002393	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839
1045854002394	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1045854002395	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
1045854002396	active site
1045854002397	phosphorylation site [posttranslational modification]
1045854002398	intermolecular recognition site; other site
1045854002399	dimerization interface [polypeptide binding]; other site
1045854002400	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
1045854002401	DNA binding site [nucleotide binding]
1045854002402	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1045854002403	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
1045854002404	dimer interface [polypeptide binding]; other site
1045854002405	phosphorylation site [posttranslational modification]
1045854002406	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1045854002407	ATP binding site [chemical binding]; other site
1045854002408	Mg2+ binding site [ion binding]; other site
1045854002409	G-X-G motif; other site
1045854002410	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1045854002411	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1045854002412	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1045854002413	catalytic residues [active]
1045854002414	Protein of unknown function (DUF805); Region: DUF805; cl01224
1045854002415	FOG: CBS domain [General function prediction only]; Region: COG0517
1045854002416	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205
1045854002417	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1045854002418	putative active site [active]
1045854002419	catalytic residue [active]
1045854002420	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1045854002421	CarD-like/TRCF domain; Region: CarD_TRCF; cl00588
1045854002422	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1045854002423	ATP binding site [chemical binding]; other site
1045854002424	putative Mg++ binding site [ion binding]; other site
1045854002425	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1045854002426	nucleotide binding region [chemical binding]; other site
1045854002427	ATP-binding site [chemical binding]; other site
1045854002428	TRCF domain; Region: TRCF; cl04088
1045854002429	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1045854002430	MatE; Region: MatE; cl10513
1045854002431	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1045854002432	RNA binding surface [nucleotide binding]; other site
1045854002433	Septum formation initiator; Region: DivIC; cl11433
1045854002434	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1045854002435	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1045854002436	Ligand Binding Site [chemical binding]; other site
1045854002437	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
1045854002438	FtsH Extracellular; Region: FtsH_ext; pfam06480
1045854002439	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1045854002440	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
1045854002441	Walker A motif; other site
1045854002442	ATP binding site [chemical binding]; other site
1045854002443	Walker B motif; other site
1045854002444	arginine finger; other site
1045854002445	Peptidase family M41; Region: Peptidase_M41; pfam01434
1045854002446	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base...; Region: nuc_hydro_CaPnhB; cd02650
1045854002447	active site
1045854002448	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1045854002449	active site
1045854002450	tetramer interface [polypeptide binding]; other site
1045854002451	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1045854002452	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1045854002453	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1045854002454	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1045854002455	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1045854002456	DNA binding site [nucleotide binding]
1045854002457	domain linker motif; other site
1045854002458	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1045854002459	dimerization interface [polypeptide binding]; other site
1045854002460	ligand binding site [chemical binding]; other site
1045854002461	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1045854002462	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1045854002463	active site
1045854002464	dimer interface [polypeptide binding]; other site
1045854002465	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1045854002466	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1045854002467	dimerization interface [polypeptide binding]; other site
1045854002468	domain crossover interface; other site
1045854002469	redox-dependent activation switch; other site
1045854002470	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1045854002471	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322
1045854002472	dimer interface [polypeptide binding]; other site
1045854002473	putative anticodon binding site; other site
1045854002474	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1045854002475	motif 1; other site
1045854002476	active site
1045854002477	motif 2; other site
1045854002478	motif 3; other site
1045854002479	Peptidase family C69; Region: Peptidase_C69; cl01920
1045854002480	Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524
1045854002481	Amino acid permease; Region: AA_permease; pfam00324
1045854002482	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1045854002483	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013
1045854002484	putative active site [active]
1045854002485	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854002486	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
1045854002487	potential protein location (hypothetical protein WKK_04200 [Weissella koreensis KACC 15510]) that overlaps RNA (tRNA-R)
1045854002488	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850
1045854002489	Clp protease ATP binding subunit; Region: clpC; CHL00095
1045854002490	Clp amino terminal domain; Region: Clp_N; pfam02861
1045854002491	Clp amino terminal domain; Region: Clp_N; pfam02861
1045854002492	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
1045854002493	Walker A motif; other site
1045854002494	ATP binding site [chemical binding]; other site
1045854002495	Walker B motif; other site
1045854002496	arginine finger; other site
1045854002497	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
1045854002498	Walker A motif; other site
1045854002499	ATP binding site [chemical binding]; other site
1045854002500	Walker B motif; other site
1045854002501	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
1045854002502	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
1045854002503	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591
1045854002504	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1045854002505	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1045854002506	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1045854002507	RPB1 interaction site [polypeptide binding]; other site
1045854002508	RPB12 interaction site [polypeptide binding]; other site
1045854002509	RPB10 interaction site [polypeptide binding]; other site
1045854002510	RPB11 interaction site [polypeptide binding]; other site
1045854002511	RPB3 interaction site [polypeptide binding]; other site
1045854002512	RPB12 interaction site [polypeptide binding]; other site
1045854002513	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1045854002514	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1045854002515	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
1045854002516	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1045854002517	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1045854002518	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1045854002519	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1045854002520	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1045854002521	G-loop; other site
1045854002522	DNA binding site [nucleotide binding]
1045854002523	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1045854002524	dimer interface [polypeptide binding]; other site
1045854002525	catalytic triad [active]
1045854002526	peroxidatic and resolving cysteines [active]
1045854002527	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1045854002528	Coenzyme A binding pocket [chemical binding]; other site
1045854002529	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1045854002530	intersubunit interface [polypeptide binding]; other site
1045854002531	active site
1045854002532	catalytic residue [active]
1045854002533	Sulfatase; Region: Sulfatase; cl10460
1045854002534	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1045854002535	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
1045854002536	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1045854002537	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1045854002538	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
1045854002539	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1045854002540	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1045854002541	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1045854002542	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1045854002543	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1045854002544	putative NAD(P) binding site [chemical binding]; other site
1045854002545	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
1045854002546	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1045854002547	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1045854002548	active site
1045854002549	Zn binding site [ion binding]; other site
1045854002550	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1045854002551	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1045854002552	putative catalytic cysteine [active]
1045854002553	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1045854002554	putative active site [active]
1045854002555	metal binding site [ion binding]; metal-binding site
1045854002556	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1045854002557	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
1045854002558	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
1045854002559	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
1045854002560	Walker A/P-loop; other site
1045854002561	ATP binding site [chemical binding]; other site
1045854002562	Q-loop/lid; other site
1045854002563	ABC transporter signature motif; other site
1045854002564	Walker B; other site
1045854002565	D-loop; other site
1045854002566	H-loop/switch region; other site
1045854002567	Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370
1045854002568	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
1045854002569	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
1045854002570	Walker A/P-loop; other site
1045854002571	ATP binding site [chemical binding]; other site
1045854002572	Q-loop/lid; other site
1045854002573	ABC transporter signature motif; other site
1045854002574	Walker B; other site
1045854002575	D-loop; other site
1045854002576	H-loop/switch region; other site
1045854002577	Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370
1045854002578	Cobalt transport protein; Region: CbiQ; cl00463
1045854002579	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1045854002580	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570
1045854002581	dimerization interface 3.5A [polypeptide binding]; other site
1045854002582	active site
1045854002583	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1045854002584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
1045854002585	Walker A motif; other site
1045854002586	ATP binding site [chemical binding]; other site
1045854002587	Walker B motif; other site
1045854002588	arginine finger; other site
1045854002589	recombination protein RecR; Reviewed; Region: recR; PRK00076
1045854002590	RecR protein; Region: RecR; pfam02132
1045854002591	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1045854002592	putative active site [active]
1045854002593	putative metal-binding site [ion binding]; other site
1045854002594	tetramer interface [polypeptide binding]; other site
1045854002595	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
1045854002596	thymidylate kinase; Validated; Region: tmk; PRK00698
1045854002597	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672
1045854002598	TMP-binding site; other site
1045854002599	ATP-binding site [chemical binding]; other site
1045854002600	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412
1045854002601	DNA polymerase III subunit delta'; Validated; Region: PRK08058
1045854002602	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854002603	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304
1045854002604	Predicted methyltransferases [General function prediction only]; Region: COG0313
1045854002605	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
1045854002606	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586
1045854002607	active site
1045854002608	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1045854002609	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1045854002610	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1045854002611	NAD binding site [chemical binding]; other site
1045854002612	homodimer interface [polypeptide binding]; other site
1045854002613	active site
1045854002614	substrate binding site [chemical binding]; other site
1045854002615	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
1045854002616	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1045854002617	active site
1045854002618	catalytic tetrad [active]
1045854002619	L-lactate permease; Region: Lactate_perm; cl00701
1045854002620	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1045854002621	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
1045854002622	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1045854002623	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1045854002624	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1045854002625	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1045854002626	potential protein location (hypothetical protein WKK_04390 [Weissella koreensis KACC 15510]) that overlaps RNA (tRNA-F)
1045854002627	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1045854002628	23S rRNA interface [nucleotide binding]; other site
1045854002629	L3 interface [polypeptide binding]; other site
1045854002630	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
1045854002631	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854002632	NAD(P) binding site [chemical binding]; other site
1045854002633	active site
1045854002634	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
1045854002635	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1045854002636	catalytic Zn binding site [ion binding]; other site
1045854002637	NAD(P) binding site [chemical binding]; other site
1045854002638	structural Zn binding site [ion binding]; other site
1045854002639	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1045854002640	Protein of unknown function (DUF554); Region: DUF554; cl00784
1045854002641	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1045854002642	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854002643	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1045854002644	dimerization interface [polypeptide binding]; other site
1045854002645	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
1045854002646	Active site [active]
1045854002647	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
1045854002648	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1045854002649	catalytic Zn binding site [ion binding]; other site
1045854002650	NAD(P) binding site [chemical binding]; other site
1045854002651	structural Zn binding site [ion binding]; other site
1045854002652	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1045854002653	putative transporter; Provisional; Region: PRK11462
1045854002654	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1045854002655	putative alpha-glucosidase; Provisional; Region: PRK10658
1045854002656	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
1045854002657	active site
1045854002658	homotrimer interface [polypeptide binding]; other site
1045854002659	catalytic site [active]
1045854002660	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
1045854002661	Cupin domain; Region: Cupin_2; cl09118
1045854002662	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1045854002663	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1045854002664	MatE; Region: MatE; cl10513
1045854002665	MatE; Region: MatE; cl10513
1045854002666	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1045854002667	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854002668	putative substrate translocation pore; other site
1045854002669	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854002670	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1045854002671	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
1045854002672	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
1045854002673	D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1045854002674	N- and C-terminal domain interface [polypeptide binding]; other site
1045854002675	D-xylulose kinase; Region: XylB; TIGR01312
1045854002676	active site
1045854002677	catalytic site [active]
1045854002678	metal binding site [ion binding]; metal-binding site
1045854002679	xylulose binding site [chemical binding]; other site
1045854002680	putative ATP binding site [chemical binding]; other site
1045854002681	homodimer interface [polypeptide binding]; other site
1045854002682	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1045854002683	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
1045854002684	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
1045854002685	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
1045854002686	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1045854002687	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
1045854002688	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1045854002689	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1045854002690	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
1045854002691	Natural resistance-associated macrophage protein; Region: Nramp; cl00836
1045854002692	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1045854002693	Ligand Binding Site [chemical binding]; other site
1045854002694	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854002695	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1045854002696	Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933
1045854002697	putative substrate binding pocket [chemical binding]; other site
1045854002698	dimer interface [polypeptide binding]; other site
1045854002699	phosphate binding site [ion binding]; other site
1045854002700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1045854002701	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1045854002702	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1045854002703	oligomer interface [polypeptide binding]; other site
1045854002704	active site residues [active]
1045854002705	Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674
1045854002706	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1045854002707	putative metal binding site [ion binding]; other site
1045854002708	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1045854002709	dimerization interface [polypeptide binding]; other site
1045854002710	putative DNA binding site [nucleotide binding]; other site
1045854002711	putative Zn2+ binding site [ion binding]; other site
1045854002712	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
1045854002713	Cadmium resistance transporter; Region: Cad; cl04177
1045854002714	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1045854002715	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1045854002716	active site
1045854002717	substrate binding site [chemical binding]; other site
1045854002718	trimer interface [polypeptide binding]; other site
1045854002719	CoA binding site [chemical binding]; other site
1045854002720	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
1045854002721	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1045854002722	Walker A motif; other site
1045854002723	ATP binding site [chemical binding]; other site
1045854002724	Walker B motif; other site
1045854002725	arginine finger; other site
1045854002726	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
1045854002727	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
1045854002728	Walker A motif; other site
1045854002729	ATP binding site [chemical binding]; other site
1045854002730	Walker B motif; other site
1045854002731	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
1045854002732	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1045854002733	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1045854002734	trimer interface [polypeptide binding]; other site
1045854002735	active site
1045854002736	DNA repair protein RadA; Provisional; Region: PRK11823
1045854002737	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1045854002738	Walker A motif/ATP binding site; other site
1045854002739	ATP binding site [chemical binding]; other site
1045854002740	Walker B motif; other site
1045854002741	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1045854002742	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1045854002743	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1045854002744	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1045854002745	putative active site [active]
1045854002746	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1045854002747	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1045854002748	active site
1045854002749	HIGH motif; other site
1045854002750	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1045854002751	active site
1045854002752	KMSKS motif; other site
1045854002753	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1045854002754	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1045854002755	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1045854002756	dimer interface [polypeptide binding]; other site
1045854002757	motif 1; other site
1045854002758	active site
1045854002759	motif 2; other site
1045854002760	motif 3; other site
1045854002761	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1045854002762	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1045854002763	putative tRNA-binding site [nucleotide binding]; other site
1045854002764	B3/4 domain; Region: B3_4; cl11458
1045854002765	tRNA synthetase B5 domain; Region: B5; cl08394
1045854002766	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1045854002767	dimer interface [polypeptide binding]; other site
1045854002768	motif 1; other site
1045854002769	motif 3; other site
1045854002770	motif 2; other site
1045854002771	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
1045854002772	YceG-like family; Region: YceG; pfam02618
1045854002773	proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675
1045854002774	dimerization interface [polypeptide binding]; other site
1045854002775	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
1045854002776	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131
1045854002777	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1045854002778	domain; Region: GreA_GreB_N; pfam03449
1045854002779	C-term; Region: GreA_GreB; pfam01272
1045854002780	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1045854002781	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1045854002782	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
1045854002783	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
1045854002784	Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543
1045854002785	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1045854002786	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
1045854002787	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
1045854002788	putative peptidoglycan binding site; other site
1045854002789	NlpC/P60 family; Region: NLPC_P60; cl11438
1045854002790	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447
1045854002791	nudix motif; other site
1045854002792	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1045854002793	active site residue [active]
1045854002794	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
1045854002795	IPP transferase; Region: IPPT; cl00403
1045854002796	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1045854002797	DNA binding residues [nucleotide binding]
1045854002798	putative dimer interface [polypeptide binding]; other site
1045854002799	glutamine synthetase, type I; Region: GlnA; TIGR00653
1045854002800	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1045854002801	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1045854002802	EamA-like transporter family; Region: EamA; cl01037
1045854002803	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1045854002804	EamA-like transporter family; Region: EamA; cl01037
1045854002805	QueT transporter; Region: QueT; cl01932
1045854002806	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
1045854002807	classical (c) SDRs; Region: SDR_c; cd05233
1045854002808	NAD(P) binding site [chemical binding]; other site
1045854002809	active site
1045854002810	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
1045854002811	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1045854002812	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1045854002813	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
1045854002814	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1045854002815	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
1045854002816	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1045854002817	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
1045854002818	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1045854002819	active site
1045854002820	dimer interface [polypeptide binding]; other site
1045854002821	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1045854002822	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1045854002823	DNA-binding site [nucleotide binding]; DNA binding site
1045854002824	UTRA domain; Region: UTRA; cl01230
1045854002825	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1045854002826	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1045854002827	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1045854002828	RNA binding surface [nucleotide binding]; other site
1045854002829	Sulfate transporter family; Region: Sulfate_transp; cl00967
1045854002830	Permease family; Region: Xan_ur_permease; pfam00860
1045854002831	adenylosuccinate synthetase; Provisional; Region: PRK01117
1045854002832	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108
1045854002833	GDP-binding site [chemical binding]; other site
1045854002834	ACT binding site; other site
1045854002835	IMP binding site; other site
1045854002836	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
1045854002837	GtrA-like protein; Region: GtrA; cl00971
1045854002838	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
1045854002839	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1045854002840	active site
1045854002841	motif I; other site
1045854002842	motif II; other site
1045854002843	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
1045854002844	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1045854002845	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1045854002846	catalytic residue [active]
1045854002847	putative FPP diphosphate  binding site; other site
1045854002848	putative FPP binding hydrophobic cleft; other site
1045854002849	dimer interface [polypeptide binding]; other site
1045854002850	putative IPP diphosphate binding site; other site
1045854002851	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
1045854002852	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1045854002853	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779
1045854002854	dimer interface [polypeptide binding]; other site
1045854002855	motif 1; other site
1045854002856	active site
1045854002857	motif 2; other site
1045854002858	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334
1045854002859	putative deacylase active site [active]
1045854002860	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1045854002861	active site
1045854002862	motif 3; other site
1045854002863	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861
1045854002864	anticodon binding site; other site
1045854002865	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
1045854002866	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1045854002867	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1045854002868	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1045854002869	generic binding surface II; other site
1045854002870	generic binding surface I; other site
1045854002871	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
1045854002872	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1045854002873	active site
1045854002874	substrate binding site [chemical binding]; other site
1045854002875	catalytic site [active]
1045854002876	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
1045854002877	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
1045854002878	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1045854002879	ATP binding site [chemical binding]; other site
1045854002880	putative Mg++ binding site [ion binding]; other site
1045854002881	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1045854002882	nucleotide binding region [chemical binding]; other site
1045854002883	ATP-binding site [chemical binding]; other site
1045854002884	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
1045854002885	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552
1045854002886	30S subunit binding site; other site
1045854002887	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1045854002888	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1045854002889	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1045854002890	active site
1045854002891	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
1045854002892	putative active site [active]
1045854002893	putative metal binding site [ion binding]; other site
1045854002894	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1045854002895	active site
1045854002896	metal binding site [ion binding]; metal-binding site
1045854002897	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1045854002898	Protein of unknown function (DUF1027); Region: DUF1027; cl09961
1045854002899	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
1045854002900	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
1045854002901	active site
1045854002902	motif I; other site
1045854002903	motif II; other site
1045854002904	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
1045854002905	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1045854002906	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1045854002907	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
1045854002908	dimer interface [polypeptide binding]; other site
1045854002909	conserved gate region; other site
1045854002910	putative PBP binding loops; other site
1045854002911	ABC-ATPase subunit interface; other site
1045854002912	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1045854002913	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
1045854002914	dimer interface [polypeptide binding]; other site
1045854002915	conserved gate region; other site
1045854002916	putative PBP binding loops; other site
1045854002917	ABC-ATPase subunit interface; other site
1045854002918	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
1045854002919	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
1045854002920	Walker A/P-loop; other site
1045854002921	ATP binding site [chemical binding]; other site
1045854002922	Q-loop/lid; other site
1045854002923	ABC transporter signature motif; other site
1045854002924	Walker B; other site
1045854002925	D-loop; other site
1045854002926	H-loop/switch region; other site
1045854002927	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
1045854002928	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
1045854002929	Walker A/P-loop; other site
1045854002930	ATP binding site [chemical binding]; other site
1045854002931	Q-loop/lid; other site
1045854002932	ABC transporter signature motif; other site
1045854002933	Walker B; other site
1045854002934	D-loop; other site
1045854002935	H-loop/switch region; other site
1045854002936	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1045854002937	PhoU domain; Region: PhoU; pfam01895
1045854002938	PhoU domain; Region: PhoU; pfam01895
1045854002939	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1045854002940	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1045854002941	septation ring formation regulator EzrA; Provisional; Region: PRK04778
1045854002942	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
1045854002943	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1045854002944	active site
1045854002945	HIGH motif; other site
1045854002946	dimer interface [polypeptide binding]; other site
1045854002947	KMSKS motif; other site
1045854002948	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1045854002949	Preprotein translocase SecG subunit; Region: SecG; cl09123
1045854002950	ribonuclease R; Region: RNase_R; TIGR02063
1045854002951	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
1045854002952	RNB domain; Region: RNB; pfam00773
1045854002953	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471
1045854002954	RNA binding site [nucleotide binding]; other site
1045854002955	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1045854002956	SmpB-tmRNA interface; other site
1045854002957	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1045854002958	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854002959	putative substrate translocation pore; other site
1045854002960	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
1045854002961	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1045854002962	Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935
1045854002963	active site
1045854002964	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
1045854002965	DNA-binding site [nucleotide binding]; DNA binding site
1045854002966	RNA-binding motif; other site
1045854002967	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
1045854002968	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1045854002969	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1045854002970	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
1045854002971	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1045854002972	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1045854002973	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1045854002974	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
1045854002975	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685
1045854002976	RNA binding site [nucleotide binding]; other site
1045854002977	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1045854002978	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
1045854002979	potential protein location (hypothetical protein WKK_04990 [Weissella koreensis KACC 15510]) that overlaps RNA (tRNA-M)
1045854002980	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1045854002981	phosphodiesterase; Provisional; Region: PRK12704
1045854002982	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
1045854002983	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1045854002984	Zn2+ binding site [ion binding]; other site
1045854002985	Mg2+ binding site [ion binding]; other site
1045854002986	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1045854002987	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1045854002988	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
1045854002989	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1045854002990	Coenzyme A binding pocket [chemical binding]; other site
1045854002991	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1045854002992	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1045854002993	nudix motif; other site
1045854002994	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1045854002995	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1045854002996	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1045854002997	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854002998	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1045854002999	B3/4 domain; Region: B3_4; cl11458
1045854003000	Permease family; Region: Xan_ur_permease; pfam00860
1045854003001	Sulfate transporter family; Region: Sulfate_transp; cl00967
1045854003002	Domain of unknown function DUF20; Region: UPF0118; cl00465
1045854003003	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293
1045854003004	cytosine deaminase; Provisional; Region: PRK05985
1045854003005	active site
1045854003006	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
1045854003007	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
1045854003008	DNA binding site [nucleotide binding]
1045854003009	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
1045854003010	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1045854003011	active site
1045854003012	catalytic residues [active]
1045854003013	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1045854003014	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1045854003015	active site
1045854003016	dimer interface [polypeptide binding]; other site
1045854003017	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1045854003018	dimer interface [polypeptide binding]; other site
1045854003019	active site
1045854003020	Domain of unknown function (DUF368); Region: DUF368; cl00893
1045854003021	elongation factor P; Validated; Region: PRK00529
1045854003022	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1045854003023	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470
1045854003024	RNA binding site [nucleotide binding]; other site
1045854003025	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794
1045854003026	RNA binding site [nucleotide binding]; other site
1045854003027	Protein of unknown function (DUF322); Region: DUF322; cl00574
1045854003028	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223
1045854003029	putative RNA binding site [nucleotide binding]; other site
1045854003030	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1045854003031	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1045854003032	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1045854003033	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
1045854003034	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1045854003035	23S rRNA binding site [nucleotide binding]; other site
1045854003036	L21 binding site [polypeptide binding]; other site
1045854003037	L13 binding site [polypeptide binding]; other site
1045854003038	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1045854003039	S17 interaction site [polypeptide binding]; other site
1045854003040	S8 interaction site; other site
1045854003041	16S rRNA interaction site [nucleotide binding]; other site
1045854003042	streptomycin interaction site [chemical binding]; other site
1045854003043	23S rRNA interaction site [nucleotide binding]; other site
1045854003044	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1045854003045	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
1045854003046	elongation factor G; Reviewed; Region: PRK12739
1045854003047	Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase).  The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA.  This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886
1045854003048	G1 box; other site
1045854003049	putative GEF interaction site [polypeptide binding]; other site
1045854003050	GTP/Mg2+ binding site [chemical binding]; other site
1045854003051	Switch I region; other site
1045854003052	G2 box; other site
1045854003053	G3 box; other site
1045854003054	Switch II region; other site
1045854003055	G4 box; other site
1045854003056	G5 box; other site
1045854003057	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088
1045854003058	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434
1045854003059	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713
1045854003060	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1045854003061	PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D.  PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300
1045854003062	Walker A/P-loop; other site
1045854003063	ATP binding site [chemical binding]; other site
1045854003064	Q-loop/lid; other site
1045854003065	ABC transporter signature motif; other site
1045854003066	Walker B; other site
1045854003067	D-loop; other site
1045854003068	H-loop/switch region; other site
1045854003069	TOBE domain; Region: TOBE_2; cl01440
1045854003070	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1045854003071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
1045854003072	dimer interface [polypeptide binding]; other site
1045854003073	conserved gate region; other site
1045854003074	putative PBP binding loops; other site
1045854003075	ABC-ATPase subunit interface; other site
1045854003076	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1045854003077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
1045854003078	dimer interface [polypeptide binding]; other site
1045854003079	conserved gate region; other site
1045854003080	putative PBP binding loops; other site
1045854003081	ABC-ATPase subunit interface; other site
1045854003082	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1045854003083	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1045854003084	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1045854003085	active site
1045854003086	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1045854003087	Ligand Binding Site [chemical binding]; other site
1045854003088	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854003089	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1045854003090	putative substrate translocation pore; other site
1045854003091	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854003092	Membrane protein of unknown function; Region: DUF360; cl00850
1045854003093	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1045854003094	DRTGG domain; Region: DRTGG; cl12147
1045854003095	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918
1045854003096	Hpr binding site; other site
1045854003097	active site
1045854003098	homohexamer subunit interaction site [polypeptide binding]; other site
1045854003099	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1045854003100	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854003101	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1045854003102	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1045854003103	active site
1045854003104	tetramer interface [polypeptide binding]; other site
1045854003105	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1045854003106	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854003107	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854003108	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1045854003109	dimerization domain swap beta strand [polypeptide binding]; other site
1045854003110	regulatory protein interface [polypeptide binding]; other site
1045854003111	active site
1045854003112	regulatory phosphorylation site [posttranslational modification]; other site
1045854003113	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1045854003114	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1045854003115	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
1045854003116	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
1045854003117	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1045854003118	substrate binding site [chemical binding]; other site
1045854003119	dimer interface [polypeptide binding]; other site
1045854003120	catalytic triad [active]
1045854003121	enolase; Provisional; Region: eno; PRK00077
1045854003122	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1045854003123	dimer interface [polypeptide binding]; other site
1045854003124	metal binding site [ion binding]; metal-binding site
1045854003125	substrate binding pocket [chemical binding]; other site
1045854003126	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
1045854003127	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1045854003128	non-specific DNA binding site [nucleotide binding]; other site
1045854003129	salt bridge; other site
1045854003130	sequence-specific DNA binding site [nucleotide binding]; other site
1045854003131	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
1045854003132	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267
1045854003133	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1045854003134	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1045854003135	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1045854003136	substrate binding site [chemical binding]; other site
1045854003137	hinge regions; other site
1045854003138	ADP binding site [chemical binding]; other site
1045854003139	catalytic site [active]
1045854003140	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
1045854003141	putative peptidoglycan binding site; other site
1045854003142	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
1045854003143	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
1045854003144	active site
1045854003145	motif I; other site
1045854003146	motif II; other site
1045854003147	GTPase YqeH; Provisional; Region: PRK13796
1045854003148	YqeH.  YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855
1045854003149	GTP/Mg2+ binding site [chemical binding]; other site
1045854003150	G4 box; other site
1045854003151	G5 box; other site
1045854003152	G1 box; other site
1045854003153	Switch I region; other site
1045854003154	G2 box; other site
1045854003155	G3 box; other site
1045854003156	Switch II region; other site
1045854003157	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
1045854003158	Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057
1045854003159	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1045854003160	active site
1045854003161	(T/H)XGH motif; other site
1045854003162	Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713
1045854003163	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1045854003164	Zn2+ binding site [ion binding]; other site
1045854003165	Mg2+ binding site [ion binding]; other site
1045854003166	Domain of unknown function DUF143; Region: DUF143; cl00519
1045854003167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
1045854003168	S-adenosylmethionine binding site [chemical binding]; other site
1045854003169	hypothetical protein; Provisional; Region: PRK13670
1045854003170	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1045854003171	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
1045854003172	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1045854003173	MutS domain I; Region: MutS_I; pfam01624
1045854003174	MutS domain II; Region: MutS_II; pfam05188
1045854003175	MutS family domain IV; Region: MutS_IV; pfam05190
1045854003176	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
1045854003177	Walker A/P-loop; other site
1045854003178	ATP binding site [chemical binding]; other site
1045854003179	Q-loop/lid; other site
1045854003180	ABC transporter signature motif; other site
1045854003181	Walker B; other site
1045854003182	D-loop; other site
1045854003183	H-loop/switch region; other site
1045854003184	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1045854003185	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1045854003186	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854003187	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1045854003188	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
1045854003189	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
1045854003190	ABC transporter; Region: ABC_tran_2; pfam12848
1045854003191	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
1045854003192	RecX family; Region: RecX; cl00936
1045854003193	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1045854003194	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1045854003195	C-terminal domain; Region: primase_Cterm; TIGR01613
1045854003196	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1045854003197	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
1045854003198	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
1045854003199	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1045854003200	Predicted transcriptional regulator [Transcription]; Region: COG1395
1045854003201	non-specific DNA binding site [nucleotide binding]; other site
1045854003202	salt bridge; other site
1045854003203	sequence-specific DNA binding site [nucleotide binding]; other site
1045854003204	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1045854003205	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1045854003206	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1045854003207	DNA binding site [nucleotide binding]
1045854003208	Int/Topo IB signature motif; other site
1045854003209	active site
1045854003210	Protein of unknown function (DUF402); Region: DUF402; cl00979
1045854003211	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
1045854003212	hypothetical protein; Validated; Region: PRK07682
1045854003213	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1045854003214	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1045854003215	homodimer interface [polypeptide binding]; other site
1045854003216	catalytic residue [active]
1045854003217	Predicted membrane protein [Function unknown]; Region: COG4684
1045854003218	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1045854003219	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
1045854003220	Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268
1045854003221	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1045854003222	Potassium binding sites [ion binding]; other site
1045854003223	Cesium cation binding sites [ion binding]; other site
1045854003224	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1045854003225	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
1045854003226	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320
1045854003227	oligomerisation interface [polypeptide binding]; other site
1045854003228	mobile loop; other site
1045854003229	roof hairpin; other site
1045854003230	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1045854003231	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1045854003232	ring oligomerisation interface [polypeptide binding]; other site
1045854003233	ATP/Mg binding site [chemical binding]; other site
1045854003234	stacking interactions; other site
1045854003235	hinge regions; other site
1045854003236	Protein of unknown function (DUF1393); Region: DUF1393; cl01942
1045854003237	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1045854003238	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1045854003239	ATP binding site [chemical binding]; other site
1045854003240	Mg2+ binding site [ion binding]; other site
1045854003241	G-X-G motif; other site
1045854003242	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1045854003243	ATP binding site [chemical binding]; other site
1045854003244	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
1045854003245	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
1045854003246	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1045854003247	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1045854003248	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
1045854003249	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1045854003250	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667
1045854003251	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
1045854003252	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1045854003253	active site
1045854003254	dimer interface [polypeptide binding]; other site
1045854003255	motif 1; other site
1045854003256	motif 2; other site
1045854003257	motif 3; other site
1045854003258	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1045854003259	anticodon binding site; other site
1045854003260	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1045854003261	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This...; Region: ABC_cobalt_CbiO_domain1; cd03225
1045854003262	Walker A/P-loop; other site
1045854003263	ATP binding site [chemical binding]; other site
1045854003264	Q-loop/lid; other site
1045854003265	ABC transporter signature motif; other site
1045854003266	Walker B; other site
1045854003267	D-loop; other site
1045854003268	H-loop/switch region; other site
1045854003269	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854003270	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540
1045854003271	Walker A/P-loop; other site
1045854003272	ATP binding site [chemical binding]; other site
1045854003273	Q-loop/lid; other site
1045854003274	ABC transporter signature motif; other site
1045854003275	Walker B; other site
1045854003276	D-loop; other site
1045854003277	H-loop/switch region; other site
1045854003278	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
1045854003279	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
1045854003280	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
1045854003281	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
1045854003282	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
1045854003283	active site
1045854003284	catalytic tetrad [active]
1045854003285	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
1045854003286	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1045854003287	active site
1045854003288	motif I; other site
1045854003289	motif II; other site
1045854003290	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
1045854003291	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
1045854003292	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
1045854003293	S-adenosylmethionine binding site [chemical binding]; other site
1045854003294	Uncharacterized conserved protein [Function unknown]; Region: COG3270
1045854003295	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
1045854003296	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1045854003297	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426
1045854003298	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1045854003299	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1045854003300	GatB domain; Region: GatB_Yqey; cl11497
1045854003301	putative lipid kinase; Reviewed; Region: PRK13055
1045854003302	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
1045854003303	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1045854003304	Domain of unknown function DUF20; Region: UPF0118; cl00465
1045854003305	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1045854003306	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1045854003307	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1045854003308	active site
1045854003309	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927
1045854003310	RNA binding site [nucleotide binding]; other site
1045854003311	potential protein location (hypothetical protein WKK_05565 [Weissella koreensis KACC 15510]) that overlaps RNA (tRNA-T)
1045854003312	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
1045854003313	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743
1045854003314	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
1045854003315	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458
1045854003316	DNA-binding site [nucleotide binding]; DNA binding site
1045854003317	RNA-binding motif; other site
1045854003318	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424
1045854003319	dimer interface [polypeptide binding]; other site
1045854003320	active site
1045854003321	ADP-ribose binding site [chemical binding]; other site
1045854003322	nudix motif; other site
1045854003323	metal binding site [ion binding]; metal-binding site
1045854003324	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1045854003325	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1045854003326	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members...; Region: Sm_like; cl00259
1045854003327	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members...; Region: Sm_like; cl00259
1045854003328	Sm1 motif; other site
1045854003329	D3 - B interaction site; other site
1045854003330	D1 - D2 interaction site; other site
1045854003331	Hfq - Hfq interaction site; other site
1045854003332	RNA binding pocket [nucleotide binding]; other site
1045854003333	Sm2 motif; other site
1045854003334	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members...; Region: Sm_like; cl00259
1045854003335	Sm1 motif; other site
1045854003336	D3 - B interaction site; other site
1045854003337	D1 - D2 interaction site; other site
1045854003338	Hfq - Hfq interaction site; other site
1045854003339	RNA binding pocket [nucleotide binding]; other site
1045854003340	Sm2 motif; other site
1045854003341	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1045854003342	NusA N-terminal domain; Region: NusA_N; pfam08529
1045854003343	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455
1045854003344	RNA binding site [nucleotide binding]; other site
1045854003345	homodimer interface [polypeptide binding]; other site
1045854003346	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1045854003347	G-X-X-G motif; other site
1045854003348	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1045854003349	putative RNA binding cleft [nucleotide binding]; other site
1045854003350	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1045854003351	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1045854003352	translation initiation factor IF-2; Region: IF-2; TIGR00487
1045854003353	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1045854003354	IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily.  IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits.  As seen in other GTPases...; Region: IF2_eIF5B; cd01887
1045854003355	G1 box; other site
1045854003356	putative GEF interaction site [polypeptide binding]; other site
1045854003357	GTP/Mg2+ binding site [chemical binding]; other site
1045854003358	Switch I region; other site
1045854003359	G2 box; other site
1045854003360	G3 box; other site
1045854003361	Switch II region; other site
1045854003362	G4 box; other site
1045854003363	G5 box; other site
1045854003364	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702
1045854003365	Translation-initiation factor 2; Region: IF-2; pfam11987
1045854003366	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692
1045854003367	Ribosome-binding factor A; Region: RBFA; cl00542
1045854003368	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1045854003369	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854003370	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
1045854003371	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
1045854003372	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1045854003373	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1045854003374	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1045854003375	elongation factor Tu; Reviewed; Region: PRK00049
1045854003376	EF-Tu subfamily.  This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts.  It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884
1045854003377	G1 box; other site
1045854003378	GEF interaction site [polypeptide binding]; other site
1045854003379	GTP/Mg2+ binding site [chemical binding]; other site
1045854003380	Switch I region; other site
1045854003381	G2 box; other site
1045854003382	G3 box; other site
1045854003383	Switch II region; other site
1045854003384	G4 box; other site
1045854003385	G5 box; other site
1045854003386	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1045854003387	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707
1045854003388	Antibiotic Binding Site [chemical binding]; other site
1045854003389	trigger factor; Provisional; Region: tig; PRK01490
1045854003390	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
1045854003391	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1045854003392	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1045854003393	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
1045854003394	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009
1045854003395	Walker A motif; other site
1045854003396	ATP binding site [chemical binding]; other site
1045854003397	Walker B motif; other site
1045854003398	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
1045854003399	The YihA (EngB) subfamily.  This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control.  YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876
1045854003400	G1 box; other site
1045854003401	GTP/Mg2+ binding site [chemical binding]; other site
1045854003402	Switch I region; other site
1045854003403	G2 box; other site
1045854003404	G3 box; other site
1045854003405	Switch II region; other site
1045854003406	G4 box; other site
1045854003407	G5 box; other site
1045854003408	Cell division protein ZapA; Region: ZapA; cl01146
1045854003409	Colicin V production protein; Region: Colicin_V; cl00567
1045854003410	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1045854003411	MutS2 homologs in bacteria and eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280
1045854003412	Walker A/P-loop; other site
1045854003413	ATP binding site [chemical binding]; other site
1045854003414	Q-loop/lid; other site
1045854003415	ABC transporter signature motif; other site
1045854003416	Walker B; other site
1045854003417	D-loop; other site
1045854003418	H-loop/switch region; other site
1045854003419	Smr domain; Region: Smr; cl02619
1045854003420	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660
1045854003421	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1045854003422	active site
1045854003423	catalytic tetrad [active]
1045854003424	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1045854003425	Flavoprotein; Region: Flavoprotein; cl08021
1045854003426	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
1045854003427	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
1045854003428	'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827
1045854003429	dimer interface [polypeptide binding]; other site
1045854003430	active site
1045854003431	Hydroxymethylglutaryl-coenzyme A synthase C terminal; Region: HMG_CoA_synt_C; pfam08540
1045854003432	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450
1045854003433	Bacterial SH3 domain; Region: SH3_3; cl02551
1045854003434	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1045854003435	active site
1045854003436	metal binding site [ion binding]; metal-binding site
1045854003437	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1045854003438	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
1045854003439	dimer interface [polypeptide binding]; other site
1045854003440	motif 1; other site
1045854003441	active site
1045854003442	motif 2; other site
1045854003443	motif 3; other site
1045854003444	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1045854003445	anticodon binding site; other site
1045854003446	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1045854003447	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1045854003448	dimer interface [polypeptide binding]; other site
1045854003449	anticodon binding site; other site
1045854003450	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
1045854003451	homodimer interface [polypeptide binding]; other site
1045854003452	motif 1; other site
1045854003453	active site
1045854003454	motif 2; other site
1045854003455	GAD domain; Region: GAD; pfam02938
1045854003456	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1045854003457	active site
1045854003458	motif 3; other site
1045854003459	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1045854003460	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1045854003461	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
1045854003462	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
1045854003463	GatB domain; Region: GatB_Yqey; cl11497
1045854003464	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
1045854003465	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
1045854003466	GTPase Era; Reviewed; Region: era; PRK00089
1045854003467	Era subfamily.  Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria.  It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163
1045854003468	G1 box; other site
1045854003469	GTP/Mg2+ binding site [chemical binding]; other site
1045854003470	Switch I region; other site
1045854003471	G2 box; other site
1045854003472	Switch II region; other site
1045854003473	G3 box; other site
1045854003474	G4 box; other site
1045854003475	G5 box; other site
1045854003476	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098
1045854003477	Recombination protein O N terminal; Region: RecO_N; pfam11967
1045854003478	DNA repair protein RecO; Region: reco; TIGR00613
1045854003479	Recombination protein O C terminal; Region: RecO_C; pfam02565
1045854003480	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
1045854003481	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
1045854003482	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573
1045854003483	RNA binding site [nucleotide binding]; other site
1045854003484	active site
1045854003485	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1045854003486	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1045854003487	active site
1045854003488	Riboflavin kinase; Region: Flavokinase; cl03312
1045854003489	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1045854003490	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1045854003491	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1045854003492	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220
1045854003493	Walker A/P-loop; other site
1045854003494	ATP binding site [chemical binding]; other site
1045854003495	Q-loop/lid; other site
1045854003496	ABC transporter signature motif; other site
1045854003497	Walker B; other site
1045854003498	D-loop; other site
1045854003499	H-loop/switch region; other site
1045854003500	ABC-2 type transporter; Region: ABC2_membrane; cl11417
1045854003501	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1045854003502	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
1045854003503	Probable Catalytic site [active]
1045854003504	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1045854003505	gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1045854003506	N- and C-terminal domain interface [polypeptide binding]; other site
1045854003507	putative active site [active]
1045854003508	catalytic site [active]
1045854003509	metal binding site [ion binding]; metal-binding site
1045854003510	carbohydrate binding site [chemical binding]; other site
1045854003511	ATP binding site [chemical binding]; other site
1045854003512	GntP family permease; Region: GntP_permease; cl15264
1045854003513	gluconate transporter; Region: gntP; TIGR00791
1045854003514	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1045854003515	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1045854003516	putative active site [active]
1045854003517	catalytic site [active]
1045854003518	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1045854003519	putative active site [active]
1045854003520	catalytic site [active]
1045854003521	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1045854003522	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1045854003523	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1045854003524	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1045854003525	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1045854003526	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258
1045854003527	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1045854003528	Competence-damaged protein; Region: CinA; cl00666
1045854003529	recombinase A; Provisional; Region: recA; PRK09354
1045854003530	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1045854003531	hexamer interface [polypeptide binding]; other site
1045854003532	Walker A motif; other site
1045854003533	ATP binding site [chemical binding]; other site
1045854003534	Walker B motif; other site
1045854003535	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1045854003536	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1045854003537	methionine aminopeptidase; Reviewed; Region: PRK07281
1045854003538	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1045854003539	active site
1045854003540	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
1045854003541	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
1045854003542	Domain of unknown function (DUF205); Region: DUF205; cl00410
1045854003543	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1045854003544	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1045854003545	DHH family; Region: DHH; pfam01368
1045854003546	DHHA1 domain; Region: DHHA1; pfam02272
1045854003547	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
1045854003548	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
1045854003549	Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722
1045854003550	Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536
1045854003551	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1045854003552	putative acyl-acceptor binding pocket; other site
1045854003553	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1045854003554	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440
1045854003555	S-adenosylmethionine binding site [chemical binding]; other site
1045854003556	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1045854003557	GIY-YIG motif/motif A; other site
1045854003558	putative active site [active]
1045854003559	putative metal binding site [ion binding]; other site
1045854003560	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1045854003561	rRNA interaction site [nucleotide binding]; other site
1045854003562	S8 interaction site; other site
1045854003563	putative laminin-1 binding site; other site
1045854003564	elongation factor Ts; Provisional; Region: tsf; PRK09377
1045854003565	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
1045854003566	Elongation factor TS; Region: EF_TS; pfam00889
1045854003567	Elongation factor TS; Region: EF_TS; pfam00889
1045854003568	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254
1045854003569	putative nucleotide binding site [chemical binding]; other site
1045854003570	uridine monophosphate binding site [chemical binding]; other site
1045854003571	homohexameric interface [polypeptide binding]; other site
1045854003572	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
1045854003573	hinge region; other site
1045854003574	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1045854003575	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714
1045854003576	glutaminase active site [active]
1045854003577	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1045854003578	dimer interface [polypeptide binding]; other site
1045854003579	active site
1045854003580	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1045854003581	dimer interface [polypeptide binding]; other site
1045854003582	active site
1045854003583	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1045854003584	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7...; Region: dNK; cd01673
1045854003585	Substrate-binding site [chemical binding]; other site
1045854003586	Substrate specificity [chemical binding]; other site
1045854003587	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1045854003588	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
1045854003589	motif II; other site
1045854003590	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1045854003591	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515
1045854003592	active site
1045854003593	dimerization interface [polypeptide binding]; other site
1045854003594	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1045854003595	active site
1045854003596	metal binding site [ion binding]; metal-binding site
1045854003597	homotetramer interface [polypeptide binding]; other site
1045854003598	Domain of unknown function (DUF1831); Region: DUF1831; pfam08866
1045854003599	adenylosuccinate lyase; Provisional; Region: PRK07492
1045854003600	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1045854003601	tetramer interface [polypeptide binding]; other site
1045854003602	active site
1045854003603	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1045854003604	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1045854003605	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
1045854003606	catalytic core [active]
1045854003607	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189
1045854003608	binding surface
1045854003609	TPR motif; other site
1045854003610	RecD/TraA family; Region: recD_rel; TIGR01448
1045854003611	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1045854003612	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1045854003613	active site
1045854003614	NTP binding site [chemical binding]; other site
1045854003615	metal binding triad [ion binding]; metal-binding site
1045854003616	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1045854003617	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1045854003618	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1045854003619	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1045854003620	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
1045854003621	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1045854003622	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
1045854003623	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
1045854003624	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
1045854003625	Competence protein CoiA-like family; Region: CoiA; cl11541
1045854003626	oligoendopeptidase F; Region: pepF; TIGR00181
1045854003627	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1045854003628	active site
1045854003629	Zn binding site [ion binding]; other site
1045854003630	glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388
1045854003631	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1045854003632	dimer interface [polypeptide binding]; other site
1045854003633	motif 1; other site
1045854003634	active site
1045854003635	motif 2; other site
1045854003636	motif 3; other site
1045854003637	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1045854003638	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1045854003639	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854003640	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
1045854003641	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854003642	putative substrate translocation pore; other site
1045854003643	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1045854003644	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261
1045854003645	dimer interface [polypeptide binding]; other site
1045854003646	conserved gate region; other site
1045854003647	putative PBP binding loops; other site
1045854003648	ABC-ATPase subunit interface; other site
1045854003649	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1045854003650	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854003651	Walker A/P-loop; other site
1045854003652	ATP binding site [chemical binding]; other site
1045854003653	Q-loop/lid; other site
1045854003654	ABC transporter signature motif; other site
1045854003655	Walker B; other site
1045854003656	D-loop; other site
1045854003657	H-loop/switch region; other site
1045854003658	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1045854003659	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134
1045854003660	substrate binding pocket [chemical binding]; other site
1045854003661	membrane-bound complex binding site; other site
1045854003662	hinge residues; other site
1045854003663	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854003664	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1045854003665	putative substrate translocation pore; other site
1045854003666	Transglycosylase; Region: Transgly; cl07896
1045854003667	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1045854003668	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039
1045854003669	Recombination protein U; Region: RecU; cl01314
1045854003670	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
1045854003671	cell division protein GpsB; Provisional; Region: PRK14127
1045854003672	DivIVA domain; Region: DivI1A_domain; TIGR03544
1045854003673	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1045854003674	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011
1045854003675	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1045854003676	UvrD/REP helicase; Region: UvrD-helicase; cl14126
1045854003677	UvrD/REP helicase; Region: UvrD-helicase; cl14126
1045854003678	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1045854003679	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1045854003680	nucleotide binding pocket [chemical binding]; other site
1045854003681	K-X-D-G motif; other site
1045854003682	catalytic site [active]
1045854003683	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1045854003684	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1045854003685	Y-family of DNA polymerases; Region: PolY; cl12025
1045854003686	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027
1045854003687	Dimer interface [polypeptide binding]; other site
1045854003688	BRCT sequence motif; other site
1045854003689	CamS sex pheromone cAM373 precursor; Region: CamS; cl11554
1045854003690	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
1045854003691	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854003692	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1045854003693	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
1045854003694	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854003695	Walker A/P-loop; other site
1045854003696	ATP binding site [chemical binding]; other site
1045854003697	Q-loop/lid; other site
1045854003698	ABC transporter signature motif; other site
1045854003699	Walker B; other site
1045854003700	D-loop; other site
1045854003701	H-loop/switch region; other site
1045854003702	excinuclease ABC subunit B; Provisional; Region: PRK05298
1045854003703	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1045854003704	ATP binding site [chemical binding]; other site
1045854003705	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1045854003706	nucleotide binding region [chemical binding]; other site
1045854003707	ATP-binding site [chemical binding]; other site
1045854003708	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1045854003709	UvrB/uvrC motif; Region: UVR; pfam02151
1045854003710	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1045854003711	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1045854003712	RNA binding surface [nucleotide binding]; other site
1045854003713	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869
1045854003714	active site
1045854003715	Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309
1045854003716	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1045854003717	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
1045854003718	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1045854003719	catalytic site [active]
1045854003720	subunit interface [polypeptide binding]; other site
1045854003721	carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369
1045854003722	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087
1045854003723	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1045854003724	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
1045854003725	Protein of unknown function (DUF322); Region: DUF322; cl00574
1045854003726	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1045854003727	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1045854003728	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1045854003729	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal...; Region: IDI-2_FMN; cd02811
1045854003730	homotetramer interface [polypeptide binding]; other site
1045854003731	FMN binding site [chemical binding]; other site
1045854003732	homodimer contacts [polypeptide binding]; other site
1045854003733	putative active site [active]
1045854003734	putative substrate binding site [chemical binding]; other site
1045854003735	Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
1045854003736	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
1045854003737	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
1045854003738	mevalonate kinase; Region: mevalon_kin; TIGR00549
1045854003739	GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256
1045854003740	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
1045854003741	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1045854003742	active site
1045854003743	substrate binding site [chemical binding]; other site
1045854003744	catalytic site [active]
1045854003745	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854003746	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854003747	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
1045854003748	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1045854003749	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1045854003750	putative dimer interface [polypeptide binding]; other site
1045854003751	putative anticodon binding site; other site
1045854003752	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776
1045854003753	homodimer interface [polypeptide binding]; other site
1045854003754	motif 1; other site
1045854003755	motif 2; other site
1045854003756	active site
1045854003757	motif 3; other site
1045854003758	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1045854003759	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099
1045854003760	Walker A/P-loop; other site
1045854003761	ATP binding site [chemical binding]; other site
1045854003762	Q-loop/lid; other site
1045854003763	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
1045854003764	ABC transporter signature motif; other site
1045854003765	Walker B; other site
1045854003766	D-loop; other site
1045854003767	ABC transporter; Region: ABC_tran_2; pfam12848
1045854003768	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221
1045854003769	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cd00209
1045854003770	folate binding site [chemical binding]; other site
1045854003771	NADP+ binding site [chemical binding]; other site
1045854003772	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
1045854003773	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1045854003774	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
1045854003775	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
1045854003776	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485
1045854003777	generic binding surface II; other site
1045854003778	generic binding surface I; other site
1045854003779	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1045854003780	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
1045854003781	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1045854003782	synthetase active site [active]
1045854003783	NTP binding site [chemical binding]; other site
1045854003784	metal binding site [ion binding]; metal-binding site
1045854003785	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668
1045854003786	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1045854003787	RelB antitoxin; Region: RelB; cl01171
1045854003788	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1045854003789	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1045854003790	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1045854003791	RNA binding surface [nucleotide binding]; other site
1045854003792	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
1045854003793	active site
1045854003794	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
1045854003795	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1045854003796	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1045854003797	ATP binding site [chemical binding]; other site
1045854003798	putative Mg++ binding site [ion binding]; other site
1045854003799	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1045854003800	nucleotide binding region [chemical binding]; other site
1045854003801	ATP-binding site [chemical binding]; other site
1045854003802	cytidylate kinase; Provisional; Region: cmk; PRK00023
1045854003803	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1045854003804	CMP-binding site; other site
1045854003805	The sites determining sugar specificity; other site
1045854003806	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1045854003807	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1045854003808	RNA binding site [nucleotide binding]; other site
1045854003809	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1045854003810	RNA binding site [nucleotide binding]; other site
1045854003811	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
1045854003812	RNA binding site [nucleotide binding]; other site
1045854003813	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692
1045854003814	RNA binding site [nucleotide binding]; other site
1045854003815	GTP-binding protein Der; Reviewed; Region: PRK00093
1045854003816	EngA1 subfamily.  This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894
1045854003817	G1 box; other site
1045854003818	GTP/Mg2+ binding site [chemical binding]; other site
1045854003819	Switch I region; other site
1045854003820	G2 box; other site
1045854003821	Switch II region; other site
1045854003822	G3 box; other site
1045854003823	G4 box; other site
1045854003824	G5 box; other site
1045854003825	EngA2 subfamily.  This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains.  Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895
1045854003826	G1 box; other site
1045854003827	GTP/Mg2+ binding site [chemical binding]; other site
1045854003828	Switch I region; other site
1045854003829	G2 box; other site
1045854003830	G3 box; other site
1045854003831	Switch II region; other site
1045854003832	G4 box; other site
1045854003833	G5 box; other site
1045854003834	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591
1045854003835	IHF dimer interface [polypeptide binding]; other site
1045854003836	IHF - DNA interface [nucleotide binding]; other site
1045854003837	Sugar transport protein; Region: Sugar_transport; pfam06800
1045854003838	sugar phosphate phosphatase; Provisional; Region: PRK10513
1045854003839	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427
1045854003840	active site
1045854003841	motif I; other site
1045854003842	motif II; other site
1045854003843	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
1045854003844	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1045854003845	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1045854003846	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1045854003847	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1045854003848	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1045854003849	tetramer interface [polypeptide binding]; other site
1045854003850	TPP-binding site [chemical binding]; other site
1045854003851	heterodimer interface [polypeptide binding]; other site
1045854003852	phosphorylation loop region [posttranslational modification]
1045854003853	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1045854003854	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1045854003855	alpha subunit interface [polypeptide binding]; other site
1045854003856	TPP binding site [chemical binding]; other site
1045854003857	heterodimer interface [polypeptide binding]; other site
1045854003858	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1045854003859	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1045854003860	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1045854003861	E3 interaction surface; other site
1045854003862	lipoyl attachment site [posttranslational modification]; other site
1045854003863	e3 binding domain; Region: E3_binding; pfam02817
1045854003864	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
1045854003865	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1045854003866	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854003867	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1045854003868	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1045854003869	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1045854003870	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1045854003871	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892
1045854003872	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1045854003873	Chain length determinant protein; Region: Wzz; cl01623
1045854003874	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1045854003875	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1045854003876	Nucleotide binding site [chemical binding]; other site
1045854003877	DTAP/Switch II; other site
1045854003878	Bacterial sugar transferase; Region: Bac_transf; cl00939
1045854003879	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1045854003880	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854003881	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1045854003882	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1045854003883	dimerization interface [polypeptide binding]; other site
1045854003884	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
1045854003885	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1045854003886	metal binding site [ion binding]; metal-binding site
1045854003887	active site
1045854003888	I-site; other site
1045854003889	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
1045854003890	NlpC/P60 family; Region: NLPC_P60; cl11438
1045854003891	Domain of unknown function (DUF74); Region: DUF74; cl00426
1045854003892	CHC2 zinc finger; Region: zf-CHC2; cl02597
1045854003893	DNA primase; Validated; Region: dnaG; PRK05667
1045854003894	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1045854003895	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1045854003896	active site
1045854003897	metal binding site [ion binding]; metal-binding site
1045854003898	interdomain interaction site; other site
1045854003899	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1045854003900	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1045854003901	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1045854003902	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1045854003903	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1045854003904	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171
1045854003905	DNA binding residues [nucleotide binding]
1045854003906	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1045854003907	HrcA protein C terminal domain; Region: HrcA; pfam01628
1045854003908	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446
1045854003909	dimer interface [polypeptide binding]; other site
1045854003910	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1045854003911	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1045854003912	chaperone protein DnaJ; Provisional; Region: PRK14294
1045854003913	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257
1045854003914	HSP70 interaction site [polypeptide binding]; other site
1045854003915	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
1045854003916	DnaJ C terminal domain; Region: DnaJ_C; pfam01556
1045854003917	Bacterial sugar transferase; Region: Bac_transf; cl00939
1045854003918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1045854003919	H+ Antiporter protein; Region: 2A0121; TIGR00900
1045854003920	putative substrate translocation pore; other site
1045854003921	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1045854003922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156
1045854003923	active site
1045854003924	phosphorylation site [posttranslational modification]
1045854003925	intermolecular recognition site; other site
1045854003926	dimerization interface [polypeptide binding]; other site
1045854003927	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383
1045854003928	DNA binding site [nucleotide binding]
1045854003929	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1045854003930	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1045854003931	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082
1045854003932	dimer interface [polypeptide binding]; other site
1045854003933	phosphorylation site [posttranslational modification]
1045854003934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1045854003935	ATP binding site [chemical binding]; other site
1045854003936	Mg2+ binding site [ion binding]; other site
1045854003937	G-X-G motif; other site
1045854003938	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage...; Region: UMPK; cd02023
1045854003939	ATP-binding site [chemical binding]; other site
1045854003940	Sugar specificity; other site
1045854003941	Pyrimidine base specificity; other site
1045854003942	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1045854003943	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1045854003944	oligomer interface [polypeptide binding]; other site
1045854003945	active site
1045854003946	metal binding site [ion binding]; metal-binding site
1045854003947	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1045854003948	putative tRNA-binding site [nucleotide binding]; other site
1045854003949	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1045854003950	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1045854003951	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1045854003952	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1045854003953	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1045854003954	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1045854003955	NAD(P) binding site [chemical binding]; other site
1045854003956	putative active site [active]
1045854003957	putative acyltransferase; Provisional; Region: PRK05790
1045854003958	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1045854003959	dimer interface [polypeptide binding]; other site
1045854003960	active site
1045854003961	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1045854003962	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1045854003963	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1045854003964	metal binding site [ion binding]; metal-binding site
1045854003965	active site
1045854003966	I-site; other site
1045854003967	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
1045854003968	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues...; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1045854003969	active site
1045854003970	homodimer interface [polypeptide binding]; other site
1045854003971	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
1045854003972	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1045854003973	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1045854003974	DXD motif; other site
1045854003975	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
1045854003976	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1045854003977	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1045854003978	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854003979	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1045854003980	dimerization interface [polypeptide binding]; other site
1045854003981	malate dehydrogenase; Provisional; Region: PRK13529
1045854003982	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1045854003983	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1045854003984	NAD(P) binding site [chemical binding]; other site
1045854003985	2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386
1045854003986	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854003987	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200
1045854003988	amphipathic channel; other site
1045854003989	Asn-Pro-Ala signature motifs; other site
1045854003990	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1045854003991	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
1045854003992	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1045854003993	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1045854003994	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
1045854003995	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
1045854003996	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1045854003997	nucleotide binding region [chemical binding]; other site
1045854003998	ATP-binding site [chemical binding]; other site
1045854003999	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
1045854004000	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
1045854004001	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
1045854004002	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
1045854004003	SecY translocase; Region: SecY; pfam00344
1045854004004	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1045854004005	Zn binding site [ion binding]; other site
1045854004006	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1045854004007	Zn binding site [ion binding]; other site
1045854004008	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1045854004009	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1045854004010	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391
1045854004011	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1045854004012	metal-binding site [ion binding]
1045854004013	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1045854004014	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1045854004015	ligand binding site [chemical binding]; other site
1045854004016	flexible hinge region; other site
1045854004017	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088
1045854004018	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252