-- dump date 20111121_015534 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 292805000001 SEQ_END SEQ_END NC_006833.1 1080084 1080084 DR NC_006833.1; contig end 1080084..1080084 Wolbachia endosymbiont strain TRS of Brugia malayi YP_197835.1 CDS Wbm0001 NC_006833.1 111 1154 D uroporphyrinogen-III decarboxylase 111..1154 Wolbachia endosymbiont strain TRS of Brugia malayi 3266947 YP_197836.1 CDS Wbm0002 NC_006833.1 1216 2409 D aspartate aminotransferase 1216..2409 Wolbachia endosymbiont strain TRS of Brugia malayi 3266742 YP_197837.1 CDS Wbm0003 NC_006833.1 2921 3112 R hypothetical protein complement(2921..3112) Wolbachia endosymbiont strain TRS of Brugia malayi 3266884 YP_197838.1 CDS Wbm0004 NC_006833.1 3826 5037 D major facilitator superfamily permease 3826..5037 Wolbachia endosymbiont strain TRS of Brugia malayi 3266234 YP_197839.1 CDS glyA NC_006833.1 5087 6364 D catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 5087..6364 Wolbachia endosymbiont strain TRS of Brugia malayi 3266592 YP_197840.1 CDS Wbm0006 NC_006833.1 7472 8665 R hypothetical protein complement(7472..8665) Wolbachia endosymbiont strain TRS of Brugia malayi 3266554 YP_197841.1 CDS era NC_006833.1 8826 9710 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 8826..9710 Wolbachia endosymbiont strain TRS of Brugia malayi 3266231 YP_197842.1 CDS Wbm0008 NC_006833.1 9703 10530 D 3'-5' exonuclease 9703..10530 Wolbachia endosymbiont strain TRS of Brugia malayi 3266262 YP_197843.1 CDS Wbm0009 NC_006833.1 11373 11558 R hypothetical protein complement(11373..11558) Wolbachia endosymbiont strain TRS of Brugia malayi 3266630 YP_197844.1 CDS Wbm0010 NC_006833.1 12128 14086 D outer membrane protein 12128..14086 Wolbachia endosymbiont strain TRS of Brugia malayi 3266620 YP_197845.1 CDS Wbm0011 NC_006833.1 16618 17835 R major facilitator superfamily permease complement(16618..17835) Wolbachia endosymbiont strain TRS of Brugia malayi 3266585 YP_197846.1 CDS aspS NC_006833.1 17935 19761 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(17935..19761) Wolbachia endosymbiont strain TRS of Brugia malayi 3266719 YP_197847.1 CDS Wbm0013 NC_006833.1 20038 20367 D hypothetical protein 20038..20367 Wolbachia endosymbiont strain TRS of Brugia malayi 3266458 YP_197848.1 CDS Wbm0014 NC_006833.1 20371 20991 D ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 20371..20991 Wolbachia endosymbiont strain TRS of Brugia malayi 3267071 YP_197849.1 CDS Wbm0015 NC_006833.1 21396 22517 R cell division membrane protein, FtsW complement(21396..22517) Wolbachia endosymbiont strain TRS of Brugia malayi 3267033 YP_197850.1 CDS Wbm0016 NC_006833.1 22569 24032 R subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; putative monovalent cation/H+ antiporter subunit D complement(22569..24032) Wolbachia endosymbiont strain TRS of Brugia malayi 3267145 YP_197851.1 CDS Wbm0017 NC_006833.1 24097 24411 D NADH:ubiquinone oxidoreductase subunit 24097..24411 Wolbachia endosymbiont strain TRS of Brugia malayi 3266605 YP_197852.1 CDS Wbm0018 NC_006833.1 24414 24869 D ABC-type transport system involved in resistance to organic solvents, periplasmic component 24414..24869 Wolbachia endosymbiont strain TRS of Brugia malayi 3266548 YP_197853.1 CDS Wbm0019 NC_006833.1 25805 28072 R polynucleotide phosphorylase/polyadenylase complement(25805..28072) Wolbachia endosymbiont strain TRS of Brugia malayi 3267097 YP_197854.1 CDS rpsO NC_006833.1 28087 28359 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(28087..28359) Wolbachia endosymbiont strain TRS of Brugia malayi 3266877 YP_197855.1 CDS Wbm0021 NC_006833.1 30740 31900 R cysteine sulfinate desulfinase/cysteine desulfurase complement(30740..31900) Wolbachia endosymbiont strain TRS of Brugia malayi 3266886 YP_197856.1 CDS Wbm0022 NC_006833.1 32034 32732 D alpha/beta fold family hydrolase 32034..32732 Wolbachia endosymbiont strain TRS of Brugia malayi 3266252 YP_197857.1 CDS Wbm0023 NC_006833.1 32933 33607 R peptide ABC transporter ATPase complement(32933..33607) Wolbachia endosymbiont strain TRS of Brugia malayi 3266256 YP_197858.1 CDS Wbm0024 NC_006833.1 33647 34096 R HesB/YadR/YfhF family protein complement(33647..34096) Wolbachia endosymbiont strain TRS of Brugia malayi 3267130 YP_197859.1 CDS Wbm0025 NC_006833.1 34144 35343 D dGTP triphosphohydrolase 34144..35343 Wolbachia endosymbiont strain TRS of Brugia malayi 3266653 YP_197860.1 CDS Wbm0026 NC_006833.1 35343 36479 D pyrimidine deaminase and reductase 35343..36479 Wolbachia endosymbiont strain TRS of Brugia malayi 3266874 YP_197861.1 CDS Wbm0027 NC_006833.1 36685 36879 R hypothetical protein complement(36685..36879) Wolbachia endosymbiont strain TRS of Brugia malayi 3266857 YP_197862.1 CDS Wbm0028 NC_006833.1 37566 38837 D catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 37566..38837 Wolbachia endosymbiont strain TRS of Brugia malayi 3267141 YP_197863.1 CDS Wbm0029 NC_006833.1 39212 39460 D hypothetical protein 39212..39460 Wolbachia endosymbiont strain TRS of Brugia malayi 3266657 YP_197864.1 CDS Wbm0030 NC_006833.1 39561 39791 D hypothetical protein 39561..39791 Wolbachia endosymbiont strain TRS of Brugia malayi 3266561 YP_197865.1 CDS Wbm0031 NC_006833.1 40246 41400 R parvulin-like peptidyl-prolyl isomerase, SurA complement(40246..41400) Wolbachia endosymbiont strain TRS of Brugia malayi 3266759 YP_197866.1 CDS trmE NC_006833.1 41626 42954 D in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 41626..42954 Wolbachia endosymbiont strain TRS of Brugia malayi 3266362 YP_197867.1 CDS Wbm0033 NC_006833.1 44876 45070 D hypothetical protein 44876..45070 Wolbachia endosymbiont strain TRS of Brugia malayi 3266241 YP_197868.1 CDS Wbm0034 NC_006833.1 45666 46010 D hypothetical protein 45666..46010 Wolbachia endosymbiont strain TRS of Brugia malayi 3266609 YP_197869.1 CDS Wbm0035 NC_006833.1 45991 46203 D hypothetical protein 45991..46203 Wolbachia endosymbiont strain TRS of Brugia malayi 3266240 YP_197870.1 CDS Wbm0036 NC_006833.1 46596 46871 D hypothetical protein 46596..46871 Wolbachia endosymbiont strain TRS of Brugia malayi 3267008 YP_197871.1 CDS Wbm0037 NC_006833.1 47028 49478 D topoisomerase IA, TopA 47028..49478 Wolbachia endosymbiont strain TRS of Brugia malayi 3266612 YP_197872.1 CDS Wbm0038 NC_006833.1 49542 50351 R sulfurtransferase complement(49542..50351) Wolbachia endosymbiont strain TRS of Brugia malayi 3266648 YP_197873.1 CDS Wbm0039 NC_006833.1 50473 52071 D ABC-type Fe3+ transport system, permease component 50473..52071 Wolbachia endosymbiont strain TRS of Brugia malayi 3267138 YP_197874.1 CDS apaG NC_006833.1 52095 52499 R protein associated with Co2+ and Mg2+ efflux; ApaG complement(52095..52499) Wolbachia endosymbiont strain TRS of Brugia malayi 3266479 YP_197875.1 CDS Wbm0041 NC_006833.1 52604 53677 D phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) 52604..53677 Wolbachia endosymbiont strain TRS of Brugia malayi 3267042 YP_197876.1 CDS Wbm0042 NC_006833.1 54209 55252 R aspartate-semialdehyde dehydrogenase complement(54209..55252) Wolbachia endosymbiont strain TRS of Brugia malayi 3267070 YP_197877.1 CDS Wbm0043 NC_006833.1 55395 55808 D hypothetical protein 55395..55808 Wolbachia endosymbiont strain TRS of Brugia malayi 3266878 YP_197878.1 CDS Wbm0044 NC_006833.1 55843 57120 R amino acid transporter complement(55843..57120) Wolbachia endosymbiont strain TRS of Brugia malayi 3267098 YP_197879.1 CDS Wbm0045 NC_006833.1 57222 58457 R amino acid transporter complement(57222..58457) Wolbachia endosymbiont strain TRS of Brugia malayi 3266882 YP_197880.1 CDS ispH NC_006833.1 58809 59738 R catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase complement(58809..59738) Wolbachia endosymbiont strain TRS of Brugia malayi 3266846 YP_197881.1 CDS Wbm0047 NC_006833.1 61327 61674 R hypothetical protein complement(61327..61674) Wolbachia endosymbiont strain TRS of Brugia malayi 3266621 YP_197882.1 CDS Wbm0048 NC_006833.1 61803 62495 R isoprenoid biosynthesis protein with amidotransferase-like domain complement(61803..62495) Wolbachia endosymbiont strain TRS of Brugia malayi 3266984 YP_197883.1 CDS Wbm0049 NC_006833.1 63711 65054 R Signal recognition particle GTPase complement(63711..65054) Wolbachia endosymbiont strain TRS of Brugia malayi 3267065 YP_197884.1 CDS Wbm0050 NC_006833.1 65039 66544 R subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; putative monovalent cation/H+ antiporter subunit D complement(65039..66544) Wolbachia endosymbiont strain TRS of Brugia malayi 3266249 YP_197885.1 CDS Wbm0051 NC_006833.1 69301 72618 R NADPH-dependent glutamate synthase beta chain complement(69301..72618) Wolbachia endosymbiont strain TRS of Brugia malayi 3266471 YP_197886.1 CDS fabZ NC_006833.1 72664 73104 R in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase complement(72664..73104) Wolbachia endosymbiont strain TRS of Brugia malayi 3266357 YP_197887.1 CDS Wbm0053 NC_006833.1 73122 73682 R Outer membrane protein complement(73122..73682) Wolbachia endosymbiont strain TRS of Brugia malayi 3267086 YP_197888.1 CDS Wbm0054 NC_006833.1 73683 76019 R Outer membrane protein/protective antigen OMA87 complement(73683..76019) Wolbachia endosymbiont strain TRS of Brugia malayi 3266608 YP_197889.1 CDS Wbm0055 NC_006833.1 76027 77151 R membrane-associated Zn-dependent protease complement(76027..77151) Wolbachia endosymbiont strain TRS of Brugia malayi 3266473 YP_197890.1 CDS Wbm0056 NC_006833.1 77248 77529 D hypothetical protein 77248..77529 Wolbachia endosymbiont strain TRS of Brugia malayi 3266838 YP_197891.1 CDS Wbm0057 NC_006833.1 77507 77824 R hypothetical protein complement(77507..77824) Wolbachia endosymbiont strain TRS of Brugia malayi 3267090 YP_197892.1 CDS Wbm0058 NC_006833.1 77897 78175 R nucleoid DNA-binding protein complement(77897..78175) Wolbachia endosymbiont strain TRS of Brugia malayi 3266232 YP_197893.1 CDS rpsA NC_006833.1 78199 79851 R in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 complement(78199..79851) Wolbachia endosymbiont strain TRS of Brugia malayi 3266261 YP_197894.1 CDS Wbm0060 NC_006833.1 80188 80397 D hypothetical protein 80188..80397 Wolbachia endosymbiont strain TRS of Brugia malayi 3266985 YP_197895.1 CDS Wbm0061 NC_006833.1 81876 83705 D stress response membrane GTPase 81876..83705 Wolbachia endosymbiont strain TRS of Brugia malayi 3266769 YP_197896.1 CDS Wbm0062 NC_006833.1 83770 84465 D hypothetical protein 83770..84465 Wolbachia endosymbiont strain TRS of Brugia malayi 3266672 YP_197897.1 CDS Wbm0063 NC_006833.1 84582 85589 D chromosome partitioning ATPase 84582..85589 Wolbachia endosymbiont strain TRS of Brugia malayi 3266314 YP_197898.1 CDS Wbm0064 NC_006833.1 85660 86817 D 2-polyprenyl-6-methoxyphenol hydroxylase, FAD-dependent oxidoreductase 85660..86817 Wolbachia endosymbiont strain TRS of Brugia malayi 3266879 YP_197899.1 CDS Wbm0065 NC_006833.1 88576 88923 R hypothetical protein complement(88576..88923) Wolbachia endosymbiont strain TRS of Brugia malayi 3266547 YP_197900.1 CDS Wbm0066 NC_006833.1 89017 89241 R hypothetical protein complement(89017..89241) Wolbachia endosymbiont strain TRS of Brugia malayi 3266771 YP_197901.1 CDS Wbm0067 NC_006833.1 89238 89459 R hypothetical protein complement(89238..89459) Wolbachia endosymbiont strain TRS of Brugia malayi 3266625 YP_197902.1 CDS Wbm0068 NC_006833.1 90084 90389 R hypothetical protein complement(90084..90389) Wolbachia endosymbiont strain TRS of Brugia malayi 3266610 YP_197903.1 CDS Wbm0069 NC_006833.1 90508 90753 R hypothetical protein complement(90508..90753) Wolbachia endosymbiont strain TRS of Brugia malayi 3266334 YP_197904.1 CDS Wbm0070 NC_006833.1 92860 94146 D Mg2+/Co2+ transporter 92860..94146 Wolbachia endosymbiont strain TRS of Brugia malayi 3266549 YP_197905.1 CDS Wbm0071 NC_006833.1 94156 94413 D hypothetical protein 94156..94413 Wolbachia endosymbiont strain TRS of Brugia malayi 3266472 YP_197906.1 CDS Wbm0072 NC_006833.1 94414 94977 D 3-polyprenyl-4-hydroxybenzoate decarboxylase 94414..94977 Wolbachia endosymbiont strain TRS of Brugia malayi 3266229 YP_197907.1 CDS Wbm0073 NC_006833.1 94981 95868 D catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 94981..95868 Wolbachia endosymbiont strain TRS of Brugia malayi 3266414 YP_197908.1 CDS Wbm0074 NC_006833.1 95919 96713 D xylanase/chitin deacetylase 95919..96713 Wolbachia endosymbiont strain TRS of Brugia malayi 3266432 YP_197909.1 CDS Wbm0075 NC_006833.1 96704 98269 D cell division protein FtsI 96704..98269 Wolbachia endosymbiont strain TRS of Brugia malayi 3266450 YP_197910.1 CDS Wbm0076 NC_006833.1 98390 99568 D WAS family protein 98390..99568 Wolbachia endosymbiont strain TRS of Brugia malayi 3266230 YP_197911.1 CDS Wbm0077 NC_006833.1 99667 100944 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 99667..100944 Wolbachia endosymbiont strain TRS of Brugia malayi 3266484 YP_197912.1 CDS acpS NC_006833.1 100941 101318 D Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 100941..101318 Wolbachia endosymbiont strain TRS of Brugia malayi 3266425 YP_197913.1 CDS Wbm0079 NC_006833.1 101341 102132 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(101341..102132) Wolbachia endosymbiont strain TRS of Brugia malayi 3267028 YP_197914.1 CDS smpB NC_006833.1 102139 102588 R binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein complement(102139..102588) Wolbachia endosymbiont strain TRS of Brugia malayi 3266749 YP_197915.1 CDS Wbm0081 NC_006833.1 103118 103330 D hypothetical protein 103118..103330 Wolbachia endosymbiont strain TRS of Brugia malayi 3266431 YP_197916.1 CDS Wbm0082 NC_006833.1 104274 104864 R hypothetical protein complement(104274..104864) Wolbachia endosymbiont strain TRS of Brugia malayi 3266623 YP_197917.1 CDS Wbm0083 NC_006833.1 104921 105517 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(104921..105517) Wolbachia endosymbiont strain TRS of Brugia malayi 3266952 YP_197918.1 CDS Wbm0084 NC_006833.1 105533 105739 R hypothetical protein complement(105533..105739) Wolbachia endosymbiont strain TRS of Brugia malayi 3266632 YP_197919.1 CDS Wbm0085 NC_006833.1 105960 106247 R hypothetical protein complement(105960..106247) Wolbachia endosymbiont strain TRS of Brugia malayi 3266470 YP_197920.1 CDS Wbm0086 NC_006833.1 106982 107209 R hypothetical protein complement(106982..107209) Wolbachia endosymbiont strain TRS of Brugia malayi 3266324 YP_197921.1 CDS pheS NC_006833.1 107354 108397 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 107354..108397 Wolbachia endosymbiont strain TRS of Brugia malayi 3266233 YP_197922.1 CDS Wbm0088 NC_006833.1 108416 109636 D N-acetylglucosamine-1-phosphate uridyltransferase 108416..109636 Wolbachia endosymbiont strain TRS of Brugia malayi 3266604 YP_197923.1 CDS Wbm0089 NC_006833.1 111715 112182 R hypothetical protein complement(111715..112182) Wolbachia endosymbiont strain TRS of Brugia malayi 3266954 YP_197924.1 CDS Wbm0090 NC_006833.1 112667 112864 R hypothetical protein complement(112667..112864) Wolbachia endosymbiont strain TRS of Brugia malayi 3266237 YP_197925.1 CDS Wbm0091 NC_006833.1 113096 113338 R hypothetical protein complement(113096..113338) Wolbachia endosymbiont strain TRS of Brugia malayi 3266236 YP_197926.1 CDS Wbm0092 NC_006833.1 113479 114093 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25/general stress protein Ctc 113479..114093 Wolbachia endosymbiont strain TRS of Brugia malayi 3266454 YP_197927.1 CDS Wbm0093 NC_006833.1 114093 114641 D Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 114093..114641 Wolbachia endosymbiont strain TRS of Brugia malayi 3266462 YP_197928.1 CDS Wbm0094 NC_006833.1 115628 115867 D hypothetical protein 115628..115867 Wolbachia endosymbiont strain TRS of Brugia malayi 3266524 YP_197929.1 CDS Wbm0095 NC_006833.1 115943 116149 D hypothetical protein 115943..116149 Wolbachia endosymbiont strain TRS of Brugia malayi 3266298 YP_197930.1 CDS Wbm0096 NC_006833.1 116557 116988 D membrane protein WF-2 116557..116988 Wolbachia endosymbiont strain TRS of Brugia malayi 3266321 YP_197931.1 CDS Wbm0097 NC_006833.1 120801 121703 D catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase 120801..121703 Wolbachia endosymbiont strain TRS of Brugia malayi 3266368 YP_197932.1 CDS Wbm0098 NC_006833.1 124063 125103 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 124063..125103 Wolbachia endosymbiont strain TRS of Brugia malayi 3266590 YP_197933.1 CDS rnc NC_006833.1 125151 125882 D cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 125151..125882 Wolbachia endosymbiont strain TRS of Brugia malayi 3267031 YP_197934.1 CDS Wbm0100 NC_006833.1 127571 128380 R Outer surface protein Wsp complement(127571..128380) Wolbachia endosymbiont strain TRS of Brugia malayi 3267037 YP_197935.1 CDS Wbm0101 NC_006833.1 128423 129658 R 2-methylthioadenine synthetase complement(128423..129658) Wolbachia endosymbiont strain TRS of Brugia malayi 3267026 YP_197936.1 CDS Wbm0102 NC_006833.1 129837 130190 R Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit complement(129837..130190) Wolbachia endosymbiont strain TRS of Brugia malayi 3267041 YP_197937.1 CDS Wbm0103 NC_006833.1 130180 131106 R phosphoribosylpyrophosphate synthetase complement(130180..131106) Wolbachia endosymbiont strain TRS of Brugia malayi 3266713 YP_197938.1 CDS Wbm0104 NC_006833.1 132148 132369 D hypothetical protein 132148..132369 Wolbachia endosymbiont strain TRS of Brugia malayi 3266670 YP_197939.1 CDS Wbm0105 NC_006833.1 132717 132929 D hypothetical protein 132717..132929 Wolbachia endosymbiont strain TRS of Brugia malayi 3266655 YP_197940.1 CDS Wbm0106 NC_006833.1 134739 135098 D hypothetical protein 134739..135098 Wolbachia endosymbiont strain TRS of Brugia malayi 3266647 YP_197941.1 CDS mraW NC_006833.1 135790 136791 D S-adenosyl-methyltransferase MraW 135790..136791 Wolbachia endosymbiont strain TRS of Brugia malayi 3266726 YP_197942.1 CDS Wbm0108 NC_006833.1 140462 141622 R dihydrolipoamide acyltransferase E2 component complement(140462..141622) Wolbachia endosymbiont strain TRS of Brugia malayi 3266832 YP_197943.1 CDS Wbm0109 NC_006833.1 142670 143320 D hypothetical protein 142670..143320 Wolbachia endosymbiont strain TRS of Brugia malayi 3266834 YP_197944.1 CDS Wbm0110 NC_006833.1 143322 143939 R hypothetical protein complement(143322..143939) Wolbachia endosymbiont strain TRS of Brugia malayi 3266835 YP_197945.1 CDS Wbm0112 NC_006833.1 146321 147103 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase complement(146321..147103) Wolbachia endosymbiont strain TRS of Brugia malayi 3266828 YP_197946.1 CDS Wbm0113 NC_006833.1 147479 148717 R actin-like ATPase complement(147479..148717) Wolbachia endosymbiont strain TRS of Brugia malayi 3266829 YP_197947.1 CDS def NC_006833.1 148853 149392 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 148853..149392 Wolbachia endosymbiont strain TRS of Brugia malayi 3266830 YP_197948.1 CDS Wbm0115 NC_006833.1 149382 150182 D Uracil-DNA glycosylase 149382..150182 Wolbachia endosymbiont strain TRS of Brugia malayi 3266831 YP_197949.1 CDS Wbm0116 NC_006833.1 151079 151336 R hypothetical protein complement(151079..151336) Wolbachia endosymbiont strain TRS of Brugia malayi 3266823 YP_197950.1 CDS Wbm0117 NC_006833.1 152403 153071 R lipoprotein complement(152403..153071) Wolbachia endosymbiont strain TRS of Brugia malayi 3266825 YP_197951.1 CDS Wbm0118 NC_006833.1 153077 154747 D UDP-N-acetylmuramate-alanine ligase 153077..154747 Wolbachia endosymbiont strain TRS of Brugia malayi 3266826 YP_197952.1 CDS eno NC_006833.1 154749 156026 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 154749..156026 Wolbachia endosymbiont strain TRS of Brugia malayi 3266258 YP_197953.1 CDS obgE NC_006833.1 156014 157036 D essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 156014..157036 Wolbachia endosymbiont strain TRS of Brugia malayi 3266820 YP_197954.1 CDS Wbm0121 NC_006833.1 157131 159701 R hypothetical protein complement(157131..159701) Wolbachia endosymbiont strain TRS of Brugia malayi 3266821 YP_197955.1 CDS Wbm0122 NC_006833.1 159698 161191 R hypothetical protein complement(159698..161191) Wolbachia endosymbiont strain TRS of Brugia malayi 3266822 YP_197956.1 CDS Wbm0123 NC_006833.1 162935 163462 R cytochrome c2 complement(162935..163462) Wolbachia endosymbiont strain TRS of Brugia malayi 3266843 YP_197957.1 CDS Wbm0124 NC_006833.1 164283 166022 D single-stranded DNA-specific exonuclease RecJ 164283..166022 Wolbachia endosymbiont strain TRS of Brugia malayi 3266871 YP_197958.1 CDS Wbm0125 NC_006833.1 166033 167205 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D complement(166033..167205) Wolbachia endosymbiont strain TRS of Brugia malayi 3266845 YP_197959.1 CDS recF NC_006833.1 168004 169074 R Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F complement(168004..169074) Wolbachia endosymbiont strain TRS of Brugia malayi 3267147 YP_197960.1 CDS Wbm0127 NC_006833.1 169091 169558 R peroxiredoxin complement(169091..169558) Wolbachia endosymbiont strain TRS of Brugia malayi 3267148 YP_197961.1 CDS Wbm0128 NC_006833.1 169618 171045 R membrane associated signal transduction histidine kinase complement(169618..171045) Wolbachia endosymbiont strain TRS of Brugia malayi 3267149 YP_197962.1 CDS argD NC_006833.1 171111 172304 D DapATase; functions in arginine biosynthetic pathway; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine transaminase protein 171111..172304 Wolbachia endosymbiont strain TRS of Brugia malayi 3267150 YP_197963.1 CDS rimM NC_006833.1 172294 172800 D Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 172294..172800 Wolbachia endosymbiont strain TRS of Brugia malayi 3267151 YP_197964.1 CDS Wbm0131 NC_006833.1 172864 173430 D translation elongation factor P, EF-P 172864..173430 Wolbachia endosymbiont strain TRS of Brugia malayi 3267152 YP_197965.1 CDS Wbm0132 NC_006833.1 173439 174137 D fructose-1,6-bisphosphatase 173439..174137 Wolbachia endosymbiont strain TRS of Brugia malayi 3267153 YP_197966.1 CDS Wbm0133 NC_006833.1 174129 175331 R catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine; 5-aminolevulinate synthase complement(174129..175331) Wolbachia endosymbiont strain TRS of Brugia malayi 3267125 YP_197967.1 CDS Wbm0134 NC_006833.1 175968 176216 R hypothetical protein complement(175968..176216) Wolbachia endosymbiont strain TRS of Brugia malayi 3267124 YP_197968.1 CDS Wbm0135 NC_006833.1 176454 176723 R hypothetical protein complement(176454..176723) Wolbachia endosymbiont strain TRS of Brugia malayi 3267119 YP_197969.1 CDS Wbm0136 NC_006833.1 178100 178654 R hypothetical protein complement(178100..178654) Wolbachia endosymbiont strain TRS of Brugia malayi 3267121 YP_197970.1 CDS Wbm0137 NC_006833.1 178688 178996 R hypothetical protein complement(178688..178996) Wolbachia endosymbiont strain TRS of Brugia malayi 3267122 YP_197971.1 CDS Wbm0138 NC_006833.1 179189 181102 R molecular chaperone; heat shock protein 90 complement(179189..181102) Wolbachia endosymbiont strain TRS of Brugia malayi 3267123 YP_197972.1 CDS Wbm0139 NC_006833.1 182083 182262 R hypothetical protein complement(182083..182262) Wolbachia endosymbiont strain TRS of Brugia malayi 3266721 YP_197973.1 CDS Wbm0140 NC_006833.1 182298 182642 R hypothetical protein complement(182298..182642) Wolbachia endosymbiont strain TRS of Brugia malayi 3266537 YP_197974.1 CDS Wbm0141 NC_006833.1 182626 182820 R hypothetical protein complement(182626..182820) Wolbachia endosymbiont strain TRS of Brugia malayi 3266671 YP_197975.1 CDS Wbm0142 NC_006833.1 183152 183691 D phosphatase 183152..183691 Wolbachia endosymbiont strain TRS of Brugia malayi 3266658 YP_197976.1 CDS Wbm0143 NC_006833.1 183691 184185 D hypothetical protein 183691..184185 Wolbachia endosymbiont strain TRS of Brugia malayi 3266892 YP_197977.1 CDS Wbm0144 NC_006833.1 184267 184662 D bacterioferritin/cytochrome b1 184267..184662 Wolbachia endosymbiont strain TRS of Brugia malayi 3266847 YP_197978.1 CDS Wbm0145 NC_006833.1 184837 185352 D SurF1 family protein 184837..185352 Wolbachia endosymbiont strain TRS of Brugia malayi 3267146 YP_197979.1 CDS Wbm0146 NC_006833.1 185400 187118 R Kef-type K+ transport system, membrane component complement(185400..187118) Wolbachia endosymbiont strain TRS of Brugia malayi 3266981 YP_197980.1 CDS Wbm0147 NC_006833.1 187124 187696 R thiol-disulfide isomerase complement(187124..187696) Wolbachia endosymbiont strain TRS of Brugia malayi 3267099 YP_197981.1 CDS Wbm0148 NC_006833.1 187805 188422 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 187805..188422 Wolbachia endosymbiont strain TRS of Brugia malayi 3267100 YP_197982.1 CDS Wbm0149 NC_006833.1 188992 189183 R hypothetical protein complement(188992..189183) Wolbachia endosymbiont strain TRS of Brugia malayi 3267102 YP_197983.1 CDS Wbm0150 NC_006833.1 189447 191276 R ATP-dependent Zn protease, HflB complement(189447..191276) Wolbachia endosymbiont strain TRS of Brugia malayi 3267103 YP_197984.1 CDS Wbm0151 NC_006833.1 191289 192584 R ATPase complement(191289..192584) Wolbachia endosymbiont strain TRS of Brugia malayi 3267104 YP_197985.1 CDS Wbm0152 NC_006833.1 192758 193237 R Outer membrane protein, pal-like complement(192758..193237) Wolbachia endosymbiont strain TRS of Brugia malayi 3267106 YP_197986.1 CDS Wbm0153 NC_006833.1 193507 194934 D Zn-dependent carboxypeptidase 193507..194934 Wolbachia endosymbiont strain TRS of Brugia malayi 3267107 YP_197987.1 CDS Wbm0154 NC_006833.1 194956 196032 D rod shape-determining protein MreB 194956..196032 Wolbachia endosymbiont strain TRS of Brugia malayi 3267108 YP_197988.1 CDS mnmA NC_006833.1 196746 197903 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 196746..197903 Wolbachia endosymbiont strain TRS of Brugia malayi 3267109 YP_197989.1 CDS Wbm0156 NC_006833.1 199597 199908 R hypothetical protein complement(199597..199908) Wolbachia endosymbiont strain TRS of Brugia malayi 3267110 YP_197990.1 CDS Wbm0157 NC_006833.1 200200 200403 R hypothetical protein complement(200200..200403) Wolbachia endosymbiont strain TRS of Brugia malayi 3267111 YP_197991.1 CDS glpX NC_006833.1 201650 202576 D type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 201650..202576 Wolbachia endosymbiont strain TRS of Brugia malayi 3267112 YP_197992.1 CDS Wbm0159 NC_006833.1 203574 204677 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(203574..204677) Wolbachia endosymbiont strain TRS of Brugia malayi 3267113 YP_197993.1 CDS Wbm0160 NC_006833.1 205874 207073 D tRNA nucleotidyltransferase/poly(A) polymerase 205874..207073 Wolbachia endosymbiont strain TRS of Brugia malayi 3267114 YP_197994.1 CDS Wbm0161 NC_006833.1 207096 207314 R hypothetical protein complement(207096..207314) Wolbachia endosymbiont strain TRS of Brugia malayi 3267115 YP_197995.1 CDS Wbm0162 NC_006833.1 207372 207554 R hypothetical protein complement(207372..207554) Wolbachia endosymbiont strain TRS of Brugia malayi 3267116 YP_197996.1 CDS Wbm0163 NC_006833.1 207502 207762 R hypothetical protein complement(207502..207762) Wolbachia endosymbiont strain TRS of Brugia malayi 3267117 YP_197997.1 CDS Wbm0164 NC_006833.1 207884 208165 R hypothetical protein complement(207884..208165) Wolbachia endosymbiont strain TRS of Brugia malayi 3267118 YP_197998.1 CDS Wbm0165 NC_006833.1 208171 208353 R hypothetical protein complement(208171..208353) Wolbachia endosymbiont strain TRS of Brugia malayi 3266733 YP_197999.1 CDS Wbm0166 NC_006833.1 209126 209356 R hypothetical protein complement(209126..209356) Wolbachia endosymbiont strain TRS of Brugia malayi 3266766 YP_198000.1 CDS Wbm0167 NC_006833.1 211325 212596 D major facilitator superfamily permease 211325..212596 Wolbachia endosymbiont strain TRS of Brugia malayi 3266481 YP_198001.1 CDS Wbm0168 NC_006833.1 213627 214058 R cytosine/adenosine deaminase complement(213627..214058) Wolbachia endosymbiont strain TRS of Brugia malayi 3266946 YP_198002.1 CDS pyrG NC_006833.1 214086 215705 R CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(214086..215705) Wolbachia endosymbiont strain TRS of Brugia malayi 3266433 YP_198003.1 CDS secG NC_006833.1 215705 216070 R preprotein translocase subunit SecG complement(215705..216070) Wolbachia endosymbiont strain TRS of Brugia malayi 3267035 YP_198004.1 CDS Wbm0171 NC_006833.1 216409 216663 D RadC-like DNA repair protein 216409..216663 Wolbachia endosymbiont strain TRS of Brugia malayi 3267092 YP_198005.1 CDS Wbm0172 NC_006833.1 218134 221493 R ATP-dependent exoDNAse (exonuclease V) beta subunit, RecB complement(218134..221493) Wolbachia endosymbiont strain TRS of Brugia malayi 3266986 YP_198006.1 CDS Wbm0173 NC_006833.1 221574 222440 D An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 221574..222440 Wolbachia endosymbiont strain TRS of Brugia malayi 3267021 YP_198007.1 CDS Wbm0174 NC_006833.1 222444 222809 D hypothetical protein 222444..222809 Wolbachia endosymbiont strain TRS of Brugia malayi 3266673 YP_198008.1 CDS Wbm0175 NC_006833.1 222811 223620 D ABC-type Mn2+/Zn2+ transport system, permease component 222811..223620 Wolbachia endosymbiont strain TRS of Brugia malayi 3266854 YP_198009.1 CDS Wbm0176 NC_006833.1 223965 224975 D DNA polymerase III delta subunit 223965..224975 Wolbachia endosymbiont strain TRS of Brugia malayi 3266355 YP_198010.1 CDS Wbm0177 NC_006833.1 226355 227149 D catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 226355..227149 Wolbachia endosymbiont strain TRS of Brugia malayi 3266789 YP_198011.1 CDS Wbm0178 NC_006833.1 227146 227904 D ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate ABC transporter ATP-binding protein 227146..227904 Wolbachia endosymbiont strain TRS of Brugia malayi 3266336 YP_198012.1 CDS Wbm0179 NC_006833.1 228435 229604 R catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase complement(228435..229604) Wolbachia endosymbiont strain TRS of Brugia malayi 3266279 YP_198013.1 CDS Wbm0180 NC_006833.1 229703 230200 R hypothetical protein complement(229703..230200) Wolbachia endosymbiont strain TRS of Brugia malayi 3266483 YP_198014.1 CDS Wbm0181 NC_006833.1 230606 233167 D ATP-binding subunit of Clp protease and DnaK/DnaJ chaperones 230606..233167 Wolbachia endosymbiont strain TRS of Brugia malayi 3266491 YP_198015.1 CDS Wbm0182 NC_006833.1 233194 237927 D NAD-specific glutamate dehydrogenase 233194..237927 Wolbachia endosymbiont strain TRS of Brugia malayi 3266596 YP_198016.1 CDS Wbm0183 NC_006833.1 237933 238241 D hypothetical protein 237933..238241 Wolbachia endosymbiont strain TRS of Brugia malayi 3267012 YP_198017.2 CDS pleD NC_006833.1 238201 239577 D involved in swarmer-to-stalked cell differentiation in Caulobacter crescentus; catalyzes the condensation of two GTP molecules to form the secondary messenger cyclic di-GMP (c-di-GMP); upon phosphorylation of domain D1 the protein dimerizes; presumably this allows the two GTP-bound GGDEF (diguanylate cyclase) domains to catalyze the condensation reaction; allosterically inhibited by c-di-GMP; response regulator PleD 238201..239577 Wolbachia endosymbiont strain TRS of Brugia malayi 3267134 YP_198018.1 CDS Wbm0185 NC_006833.1 240660 240944 D hypothetical protein 240660..240944 Wolbachia endosymbiont strain TRS of Brugia malayi 3266356 YP_198019.1 CDS secF NC_006833.1 241051 241932 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 241051..241932 Wolbachia endosymbiont strain TRS of Brugia malayi 3266681 YP_198020.1 CDS Wbm0187 NC_006833.1 241909 242481 R aspartyl protease complement(241909..242481) Wolbachia endosymbiont strain TRS of Brugia malayi 3266546 YP_198021.1 CDS Wbm0188 NC_006833.1 242694 244412 D functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 242694..244412 Wolbachia endosymbiont strain TRS of Brugia malayi 3266339 YP_198022.1 CDS ribH NC_006833.1 244390 244818 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 244390..244818 Wolbachia endosymbiont strain TRS of Brugia malayi 3266639 YP_198023.1 CDS Wbm0190 NC_006833.1 244818 245300 D transcription termination factor, NusB 244818..245300 Wolbachia endosymbiont strain TRS of Brugia malayi 3266352 YP_198024.1 CDS Wbm0191 NC_006833.1 245432 245695 D translation initiation factor 1, IF-1 245432..245695 Wolbachia endosymbiont strain TRS of Brugia malayi 3266784 YP_198025.1 CDS Wbm0192 NC_006833.1 245673 246269 D Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 245673..246269 Wolbachia endosymbiont strain TRS of Brugia malayi 3266958 YP_198026.1 CDS Wbm0193 NC_006833.1 246261 248990 R hypothetical protein complement(246261..248990) Wolbachia endosymbiont strain TRS of Brugia malayi 3266631 YP_198027.1 CDS Wbm0194 NC_006833.1 249592 251352 R DNA primase, DnaG complement(249592..251352) Wolbachia endosymbiont strain TRS of Brugia malayi 3266556 YP_198028.1 CDS Wbm0195 NC_006833.1 251498 252706 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 251498..252706 Wolbachia endosymbiont strain TRS of Brugia malayi 3267056 YP_198029.1 CDS Wbm0196 NC_006833.1 253249 254871 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 253249..254871 Wolbachia endosymbiont strain TRS of Brugia malayi 3266837 YP_198030.1 CDS Wbm0197 NC_006833.1 256625 258013 D Na+/alanine symporter 256625..258013 Wolbachia endosymbiont strain TRS of Brugia malayi 3266565 YP_198031.1 CDS Wbm0198 NC_006833.1 258454 258768 D hypothetical protein 258454..258768 Wolbachia endosymbiont strain TRS of Brugia malayi 3266642 YP_198032.1 CDS Wbm0199 NC_006833.1 259354 259686 D hypothetical protein 259354..259686 Wolbachia endosymbiont strain TRS of Brugia malayi 3267025 YP_198033.1 CDS Wbm0200 NC_006833.1 262003 262191 D hypothetical protein 262003..262191 Wolbachia endosymbiont strain TRS of Brugia malayi 3266487 YP_198034.1 CDS Wbm0201 NC_006833.1 262522 263688 R major facilitator superfamily permease complement(262522..263688) Wolbachia endosymbiont strain TRS of Brugia malayi 3266421 YP_198035.1 CDS Wbm0202 NC_006833.1 264364 265062 D ubiquinone/menaquinone biosynthesis methylase 264364..265062 Wolbachia endosymbiont strain TRS of Brugia malayi 3266451 YP_198036.1 CDS Wbm0203 NC_006833.1 266254 267960 D ABC-type multidrug transport system, ATPase and permease component 266254..267960 Wolbachia endosymbiont strain TRS of Brugia malayi 3267077 YP_198037.1 CDS Wbm0204 NC_006833.1 269587 269853 R hypothetical protein complement(269587..269853) Wolbachia endosymbiont strain TRS of Brugia malayi 3266912 YP_198038.1 CDS argS NC_006833.1 270033 271730 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 270033..271730 Wolbachia endosymbiont strain TRS of Brugia malayi 3266960 YP_198039.1 CDS Wbm0206 NC_006833.1 273242 274411 D pseudouridylate synthase, 23S RNA-specific 273242..274411 Wolbachia endosymbiont strain TRS of Brugia malayi 3266415 YP_198040.1 CDS Wbm0207 NC_006833.1 274872 275861 R pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase E1 component, alpha subunit complement(274872..275861) Wolbachia endosymbiont strain TRS of Brugia malayi 3266555 YP_198041.1 CDS Wbm0208 NC_006833.1 275976 276356 D hypothetical protein 275976..276356 Wolbachia endosymbiont strain TRS of Brugia malayi 3266999 YP_198042.1 CDS Wbm0209 NC_006833.1 276356 279025 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 276356..279025 Wolbachia endosymbiont strain TRS of Brugia malayi 3266715 YP_198043.2 CDS dapA NC_006833.1 280943 281845 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(280943..281845) Wolbachia endosymbiont strain TRS of Brugia malayi 3266864 YP_198044.1 CDS Wbm0211 NC_006833.1 281855 282337 R single-stranded DNA-binding protein, ssb complement(281855..282337) Wolbachia endosymbiont strain TRS of Brugia malayi 3266566 YP_198045.1 CDS Wbm0212 NC_006833.1 282709 282942 D hypothetical protein 282709..282942 Wolbachia endosymbiont strain TRS of Brugia malayi 3266597 YP_198046.1 CDS Wbm0213 NC_006833.1 283449 284264 R hypothetical protein complement(283449..284264) Wolbachia endosymbiont strain TRS of Brugia malayi 3266694 YP_198047.1 CDS Wbm0214 NC_006833.1 284269 284877 R hypothetical protein complement(284269..284877) Wolbachia endosymbiont strain TRS of Brugia malayi 3266707 YP_198048.1 CDS Wbm0215 NC_006833.1 284882 286321 R hypothetical protein complement(284882..286321) Wolbachia endosymbiont strain TRS of Brugia malayi 3266883 YP_198049.1 CDS Wbm0216 NC_006833.1 287111 288733 R ABC-type protease secretion system, ATPase and permease component, AprD complement(287111..288733) Wolbachia endosymbiont strain TRS of Brugia malayi 3266536 YP_198050.1 CDS Wbm0217 NC_006833.1 289041 290048 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease complement(289041..290048) Wolbachia endosymbiont strain TRS of Brugia malayi 3266413 YP_198051.1 CDS Wbm0218 NC_006833.1 290382 290588 R hypothetical protein complement(290382..290588) Wolbachia endosymbiont strain TRS of Brugia malayi 3266913 YP_198052.1 CDS Wbm0219 NC_006833.1 291217 291579 R hypothetical protein complement(291217..291579) Wolbachia endosymbiont strain TRS of Brugia malayi 3266806 YP_198053.1 CDS Wbm0220 NC_006833.1 291756 292364 D superoxide dismutase, SodA 291756..292364 Wolbachia endosymbiont strain TRS of Brugia malayi 3267095 YP_198054.1 CDS Wbm0221 NC_006833.1 292372 293637 D Zn-dependent peptidase 292372..293637 Wolbachia endosymbiont strain TRS of Brugia malayi 3266614 YP_198055.1 CDS Wbm0222 NC_006833.1 294345 294779 D preprotein translocase subunit YajC 294345..294779 Wolbachia endosymbiont strain TRS of Brugia malayi 3266259 YP_198056.1 CDS Wbm0223 NC_006833.1 294804 296624 D glucosamine 6-phosphate synthetase 294804..296624 Wolbachia endosymbiont strain TRS of Brugia malayi 3267030 YP_198057.1 CDS Wbm0224 NC_006833.1 297349 297627 R hypothetical protein complement(297349..297627) Wolbachia endosymbiont strain TRS of Brugia malayi 3266659 YP_198058.1 CDS Wbm0225 NC_006833.1 297708 298001 R hypothetical protein complement(297708..298001) Wolbachia endosymbiont strain TRS of Brugia malayi 3266651 YP_198059.1 CDS Wbm0226 NC_006833.1 298129 299169 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 298129..299169 Wolbachia endosymbiont strain TRS of Brugia malayi 3266559 YP_198060.1 CDS Wbm0227 NC_006833.1 299170 299892 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase complement(299170..299892) Wolbachia endosymbiont strain TRS of Brugia malayi 3266558 YP_198061.1 CDS trmD NC_006833.1 299961 300668 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 299961..300668 Wolbachia endosymbiont strain TRS of Brugia malayi 3266539 YP_198062.1 CDS rplS NC_006833.1 300652 301029 D this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 300652..301029 Wolbachia endosymbiont strain TRS of Brugia malayi 3266613 YP_198063.1 CDS Wbm0230 NC_006833.1 301051 301410 D hypothetical protein 301051..301410 Wolbachia endosymbiont strain TRS of Brugia malayi 3267093 YP_198064.1 CDS Wbm0231 NC_006833.1 301435 302685 D ABC-type phosphate transport system, permease component 301435..302685 Wolbachia endosymbiont strain TRS of Brugia malayi 3266540 YP_198065.1 CDS Wbm0232 NC_006833.1 302689 303486 D phosphoribosylformylglycinamidine synthase domain-containing protein 302689..303486 Wolbachia endosymbiont strain TRS of Brugia malayi 3266504 YP_198066.1 CDS lipB NC_006833.1 304616 305233 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(304616..305233) Wolbachia endosymbiont strain TRS of Brugia malayi 3266637 YP_198067.1 CDS Wbm0236 NC_006833.1 305419 306099 R Pentose-5-phosphate-3-epimerase complement(305419..306099) Wolbachia endosymbiont strain TRS of Brugia malayi 3266633 YP_198068.1 CDS Wbm0237 NC_006833.1 306373 307323 R nucleoside-diphosphate-sugar epimerase complement(306373..307323) Wolbachia endosymbiont strain TRS of Brugia malayi 3267001 YP_198069.1 CDS Wbm0238 NC_006833.1 307372 308739 R UDP-N-acetylmuramyl pentapeptide synthase complement(307372..308739) Wolbachia endosymbiont strain TRS of Brugia malayi 3266911 YP_198070.1 CDS Wbm0239 NC_006833.1 308923 309897 D hypothetical protein 308923..309897 Wolbachia endosymbiont strain TRS of Brugia malayi 3266901 YP_198071.1 CDS Wbm0240 NC_006833.1 309894 310262 D HIT family hydrolase 309894..310262 Wolbachia endosymbiont strain TRS of Brugia malayi 3266607 YP_198072.1 CDS Wbm0241 NC_006833.1 310288 310641 D NADH:ubiquinone oxidoreductase chain A 310288..310641 Wolbachia endosymbiont strain TRS of Brugia malayi 3266640 YP_198073.1 CDS Wbm0242 NC_006833.1 310646 311152 D The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 310646..311152 Wolbachia endosymbiont strain TRS of Brugia malayi 3266839 YP_198074.1 CDS Wbm0243 NC_006833.1 311154 311726 D NADH:ubiquinone oxidoreductase chain C 311154..311726 Wolbachia endosymbiont strain TRS of Brugia malayi 3266775 YP_198075.1 CDS Wbm0244 NC_006833.1 311729 312679 D Catalyzes the reversible oxidation of malate to oxaloacetate; malate dehydrogenase 311729..312679 Wolbachia endosymbiont strain TRS of Brugia malayi 3266757 YP_198076.1 CDS Wbm0245 NC_006833.1 312694 313482 R Mg-dependent Dnase, TadD complement(312694..313482) Wolbachia endosymbiont strain TRS of Brugia malayi 3266756 YP_198077.1 CDS Wbm0246 NC_006833.1 313499 313984 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(313499..313984) Wolbachia endosymbiont strain TRS of Brugia malayi 3266735 YP_198078.1 CDS Wbm0247 NC_006833.1 314730 315056 D hypothetical protein 314730..315056 Wolbachia endosymbiont strain TRS of Brugia malayi 3267085 YP_198079.1 CDS Wbm0248 NC_006833.1 315115 316365 D tyrosyl-tRNA synthetase 315115..316365 Wolbachia endosymbiont strain TRS of Brugia malayi 3266410 YP_198080.1 CDS Wbm0249 NC_006833.1 316706 316954 D hypothetical protein 316706..316954 Wolbachia endosymbiont strain TRS of Brugia malayi 3266404 YP_198081.1 CDS Wbm0250 NC_006833.1 318040 318228 D hypothetical protein 318040..318228 Wolbachia endosymbiont strain TRS of Brugia malayi 3266582 YP_198082.1 CDS ruvA NC_006833.1 318469 319059 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 318469..319059 Wolbachia endosymbiont strain TRS of Brugia malayi 3266349 YP_198083.1 CDS ruvB NC_006833.1 319037 320017 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 319037..320017 Wolbachia endosymbiont strain TRS of Brugia malayi 3266480 YP_198084.1 CDS Wbm0253 NC_006833.1 320092 321000 D hypothetical protein 320092..321000 Wolbachia endosymbiont strain TRS of Brugia malayi 3266474 YP_198085.1 CDS Wbm0254 NC_006833.1 321033 321566 D responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase 321033..321566 Wolbachia endosymbiont strain TRS of Brugia malayi 3266307 YP_198086.1 CDS Wbm0255 NC_006833.1 321593 322978 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(321593..322978) Wolbachia endosymbiont strain TRS of Brugia malayi 3266281 YP_198087.1 CDS Wbm0256 NC_006833.1 323733 324275 D 5-formyltetrahydrofolate cyclo-ligase 323733..324275 Wolbachia endosymbiont strain TRS of Brugia malayi 3266301 YP_198088.1 CDS Wbm0257 NC_006833.1 325884 328343 D This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 325884..328343 Wolbachia endosymbiont strain TRS of Brugia malayi 3266364 YP_198089.1 CDS Wbm0258 NC_006833.1 328410 329609 D ribonuclease D 328410..329609 Wolbachia endosymbiont strain TRS of Brugia malayi 3266538 YP_198090.1 CDS Wbm0259 NC_006833.1 329592 330179 R dephospho-CoA kinase complement(329592..330179) Wolbachia endosymbiont strain TRS of Brugia malayi 3266699 YP_198091.1 CDS Wbm0260 NC_006833.1 330367 331749 D 2-nitropropane dioxygenase-like protein 330367..331749 Wolbachia endosymbiont strain TRS of Brugia malayi 3266675 YP_198092.1 CDS Wbm0261 NC_006833.1 332005 332277 D hypothetical protein 332005..332277 Wolbachia endosymbiont strain TRS of Brugia malayi 3266644 YP_198093.1 CDS Wbm0262 NC_006833.1 332279 332656 D hypothetical protein 332279..332656 Wolbachia endosymbiont strain TRS of Brugia malayi 3267082 YP_198094.1 CDS Wbm0263 NC_006833.1 333919 336735 D excinuclease ATPase subunit, UvrA 333919..336735 Wolbachia endosymbiont strain TRS of Brugia malayi 3266353 YP_198095.1 CDS Wbm0264 NC_006833.1 337109 337303 D hypothetical protein 337109..337303 Wolbachia endosymbiont strain TRS of Brugia malayi 3266502 YP_198096.1 CDS Wbm0265 NC_006833.1 337613 337999 D hypothetical protein 337613..337999 Wolbachia endosymbiont strain TRS of Brugia malayi 3266300 YP_198097.1 CDS secA NC_006833.1 343063 345720 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 343063..345720 Wolbachia endosymbiont strain TRS of Brugia malayi 3267143 YP_198098.1 CDS nrdF NC_006833.1 346460 347455 R B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta complement(346460..347455) Wolbachia endosymbiont strain TRS of Brugia malayi 3266570 YP_198099.1 CDS Wbm0268 NC_006833.1 347588 347923 D small protein A, tmRNA-binding 347588..347923 Wolbachia endosymbiont strain TRS of Brugia malayi 3266595 YP_198100.1 CDS Wbm0269 NC_006833.1 348899 349147 R hypothetical protein complement(348899..349147) Wolbachia endosymbiont strain TRS of Brugia malayi 3266803 YP_198101.1 CDS Wbm0270 NC_006833.1 349144 349350 R hypothetical protein complement(349144..349350) Wolbachia endosymbiont strain TRS of Brugia malayi 3266215 YP_198102.1 CDS Wbm0271 NC_006833.1 350302 353439 R phosphoribosylformylglycinamidine synthase domain-containing protein complement(350302..353439) Wolbachia endosymbiont strain TRS of Brugia malayi 3267007 YP_198103.1 CDS Wbm0272 NC_006833.1 353537 356203 D RecB exonuclease 353537..356203 Wolbachia endosymbiont strain TRS of Brugia malayi 3266794 YP_198104.1 CDS Wbm0273 NC_006833.1 357011 358318 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 357011..358318 Wolbachia endosymbiont strain TRS of Brugia malayi 3266220 YP_198105.1 CDS Wbm0274 NC_006833.1 359503 359697 D hypothetical protein 359503..359697 Wolbachia endosymbiont strain TRS of Brugia malayi 3266798 YP_198106.1 CDS Wbm0275 NC_006833.1 360122 360850 R glutamine synthetase complement(360122..360850) Wolbachia endosymbiont strain TRS of Brugia malayi 3266812 YP_198107.1 CDS dnaA NC_006833.1 361157 362539 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 361157..362539 Wolbachia endosymbiont strain TRS of Brugia malayi 3266808 YP_198108.1 CDS Wbm0277 NC_006833.1 362563 363813 R calcineurin-like phosphoesterase complement(362563..363813) Wolbachia endosymbiont strain TRS of Brugia malayi 3266619 YP_198109.1 CDS Wbm0278 NC_006833.1 364122 365204 D GTP cyclohydrolase II 364122..365204 Wolbachia endosymbiont strain TRS of Brugia malayi 3266222 YP_198110.1 CDS Wbm0279 NC_006833.1 365277 365960 D Type IV secretory pathway, component VirB8 365277..365960 Wolbachia endosymbiont strain TRS of Brugia malayi 3266800 YP_198111.1 CDS Wbm0280 NC_006833.1 365947 366753 D Type IV secretory pathway, component VirB9 365947..366753 Wolbachia endosymbiont strain TRS of Brugia malayi 3266814 YP_198112.1 CDS Wbm0281 NC_006833.1 366770 368266 D Type IV secretory pathway, VirB10 component 366770..368266 Wolbachia endosymbiont strain TRS of Brugia malayi 3266801 YP_198113.1 CDS Wbm0282 NC_006833.1 368268 369275 D type IV secretion system ATPase VirB11 368268..369275 Wolbachia endosymbiont strain TRS of Brugia malayi 3266804 YP_198114.1 CDS Wbm0283 NC_006833.1 369289 371319 D type IV secretion system component VirD4 369289..371319 Wolbachia endosymbiont strain TRS of Brugia malayi 3266805 YP_198115.1 CDS Wbm0284 NC_006833.1 371438 372283 D Outer surface protein Wsp 371438..372283 Wolbachia endosymbiont strain TRS of Brugia malayi 3266802 YP_198116.1 CDS Wbm0285 NC_006833.1 372470 373405 R methylase of polypeptide chain release factor complement(372470..373405) Wolbachia endosymbiont strain TRS of Brugia malayi 3266225 YP_198117.1 CDS Wbm0286 NC_006833.1 374614 376602 D cytochrome c biogenesis factor 374614..376602 Wolbachia endosymbiont strain TRS of Brugia malayi 3266223 YP_198118.1 CDS Wbm0287 NC_006833.1 376943 377188 D ankyrin repeat-containing protein 376943..377188 Wolbachia endosymbiont strain TRS of Brugia malayi 3266618 YP_198119.2 CDS recO NC_006833.1 377751 378473 R involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(377751..378473) Wolbachia endosymbiont strain TRS of Brugia malayi 3266813 YP_198120.1 CDS Wbm0289 NC_006833.1 378502 379032 R carbonic anhydrase complement(378502..379032) Wolbachia endosymbiont strain TRS of Brugia malayi 3266221 YP_198121.1 CDS Wbm0290 NC_006833.1 379152 380264 D D-alanyl-D-alanine carboxypeptidase 379152..380264 Wolbachia endosymbiont strain TRS of Brugia malayi 3266807 YP_198122.1 CDS Wbm0291 NC_006833.1 380929 381957 D membrane protein WF-2 380929..381957 Wolbachia endosymbiont strain TRS of Brugia malayi 3266224 YP_198123.1 CDS dcd NC_006833.1 381964 382521 R Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase complement(381964..382521) Wolbachia endosymbiont strain TRS of Brugia malayi 3266799 YP_198124.1 CDS Wbm0293 NC_006833.1 384143 385159 R ABC-type phosphate transport system, periplasmic component complement(384143..385159) Wolbachia endosymbiont strain TRS of Brugia malayi 3266214 YP_198125.1 CDS Wbm0294 NC_006833.1 385334 386704 R Mg/Co/Ni transporter MgtE complement(385334..386704) Wolbachia endosymbiont strain TRS of Brugia malayi 3266727 YP_198126.1 CDS Wbm0295 NC_006833.1 386953 387963 D protein chain release factor B 386953..387963 Wolbachia endosymbiont strain TRS of Brugia malayi 3266817 YP_198127.1 CDS Wbm0296 NC_006833.1 388487 389809 D ankyrin repeat-containing protein 388487..389809 Wolbachia endosymbiont strain TRS of Brugia malayi 3266797 YP_198128.1 CDS Wbm0297 NC_006833.1 391599 392366 R Sec-independent protein secretion pathway component, TatC complement(391599..392366) Wolbachia endosymbiont strain TRS of Brugia malayi 3266811 YP_198129.1 CDS Wbm0298 NC_006833.1 392363 393349 R glyceraldehyde-3-phosphate dehydrogenase, GapA complement(392363..393349) Wolbachia endosymbiont strain TRS of Brugia malayi 3266815 YP_198130.1 CDS Wbm0299 NC_006833.1 394471 395922 R unwinds double stranded DNA; replicative DNA helicase complement(394471..395922) Wolbachia endosymbiont strain TRS of Brugia malayi 3266216 YP_198131.1 CDS Wbm0300 NC_006833.1 396139 396762 D hypothetical protein 396139..396762 Wolbachia endosymbiont strain TRS of Brugia malayi 3266218 YP_198132.1 CDS Wbm0301 NC_006833.1 397793 398134 D hypothetical protein 397793..398134 Wolbachia endosymbiont strain TRS of Brugia malayi 3266809 YP_198133.1 CDS rpmB NC_006833.1 398172 398486 D required for 70S ribosome assembly; 50S ribosomal protein L28 398172..398486 Wolbachia endosymbiont strain TRS of Brugia malayi 3266219 YP_198134.1 CDS Wbm0303 NC_006833.1 398479 399342 D catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 398479..399342 Wolbachia endosymbiont strain TRS of Brugia malayi 3266666 YP_198135.1 CDS Wbm0304 NC_006833.1 401150 404101 R outer membrane protein complement(401150..404101) Wolbachia endosymbiont strain TRS of Brugia malayi 3266816 YP_198136.1 CDS Wbm0305 NC_006833.1 404094 404504 R ribonuclease HI complement(404094..404504) Wolbachia endosymbiont strain TRS of Brugia malayi 3266587 YP_198137.1 CDS Wbm0306 NC_006833.1 404725 405612 R converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase complement(404725..405612) Wolbachia endosymbiont strain TRS of Brugia malayi 3266588 YP_198138.1 CDS Wbm0307 NC_006833.1 405614 407164 R cytochrome c oxidase, subunit 1 complement(405614..407164) Wolbachia endosymbiont strain TRS of Brugia malayi 3266796 YP_198139.1 CDS Wbm0308 NC_006833.1 407181 407945 R cytochrome c oxidase, subunit 2 complement(407181..407945) Wolbachia endosymbiont strain TRS of Brugia malayi 3266745 YP_198140.1 CDS Wbm0309 NC_006833.1 409599 411044 R membrane-fusion protein complement(409599..411044) Wolbachia endosymbiont strain TRS of Brugia malayi 3266971 YP_198141.1 CDS Wbm0310 NC_006833.1 411347 412081 D Short-chain alcohol dehydrogenase family enzyme 411347..412081 Wolbachia endosymbiont strain TRS of Brugia malayi 3266942 YP_198142.1 CDS Wbm0311 NC_006833.1 412551 413741 R TPR repeat-containing Zn-dependent protease complement(412551..413741) Wolbachia endosymbiont strain TRS of Brugia malayi 3266919 YP_198143.1 CDS Wbm0312 NC_006833.1 413903 414556 R 3,4-dihydroxy-2-butanone 4-phosphate synthase complement(413903..414556) Wolbachia endosymbiont strain TRS of Brugia malayi 3266369 YP_198144.1 CDS Wbm0313 NC_006833.1 414560 415054 R transcription elongation factor, GreA complement(414560..415054) Wolbachia endosymbiont strain TRS of Brugia malayi 3267076 YP_198145.1 CDS Wbm0314 NC_006833.1 415063 416604 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(415063..416604) Wolbachia endosymbiont strain TRS of Brugia malayi 3266351 YP_198146.1 CDS Wbm0315 NC_006833.1 416601 417161 R F0F1-type ATP synthase, delta subunit complement(416601..417161) Wolbachia endosymbiont strain TRS of Brugia malayi 3266323 YP_198147.1 CDS Wbm0316 NC_006833.1 417191 417535 R endonuclease complement(417191..417535) Wolbachia endosymbiont strain TRS of Brugia malayi 3266306 YP_198148.1 CDS rplQ NC_006833.1 417554 417982 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(417554..417982) Wolbachia endosymbiont strain TRS of Brugia malayi 3266449 YP_198149.1 CDS Wbm0318 NC_006833.1 417990 419057 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(417990..419057) Wolbachia endosymbiont strain TRS of Brugia malayi 3266440 YP_198150.1 CDS Wbm0319 NC_006833.1 419079 419465 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(419079..419465) Wolbachia endosymbiont strain TRS of Brugia malayi 3266430 YP_198151.1 CDS rpsM NC_006833.1 419487 419855 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(419487..419855) Wolbachia endosymbiont strain TRS of Brugia malayi 3266516 YP_198152.1 CDS Wbm0321 NC_006833.1 419914 420564 R adenylate kinase complement(419914..420564) Wolbachia endosymbiont strain TRS of Brugia malayi 3266488 YP_198153.1 CDS secY NC_006833.1 420561 421889 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(420561..421889) Wolbachia endosymbiont strain TRS of Brugia malayi 3266486 YP_198154.1 CDS rplO NC_006833.1 421893 422363 R late assembly protein; 50S ribosomal protein L15 complement(421893..422363) Wolbachia endosymbiont strain TRS of Brugia malayi 3266478 YP_198155.1 CDS rpsE NC_006833.1 422367 422879 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(422367..422879) Wolbachia endosymbiont strain TRS of Brugia malayi 3266466 YP_198156.1 CDS rplR NC_006833.1 422892 423263 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(422892..423263) Wolbachia endosymbiont strain TRS of Brugia malayi 3266455 YP_198157.1 CDS rplF NC_006833.1 423269 423814 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(423269..423814) Wolbachia endosymbiont strain TRS of Brugia malayi 3266245 YP_198158.1 CDS rpsH NC_006833.1 423831 424226 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(423831..424226) Wolbachia endosymbiont strain TRS of Brugia malayi 3266239 YP_198159.1 CDS rpsN NC_006833.1 424248 424556 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 complement(424248..424556) Wolbachia endosymbiont strain TRS of Brugia malayi 3266235 YP_198160.1 CDS rplE NC_006833.1 424573 425106 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(424573..425106) Wolbachia endosymbiont strain TRS of Brugia malayi 3266265 YP_198161.1 CDS rplX NC_006833.1 425113 425430 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(425113..425430) Wolbachia endosymbiont strain TRS of Brugia malayi 3266636 YP_198162.1 CDS rplN NC_006833.1 425430 425789 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(425430..425789) Wolbachia endosymbiont strain TRS of Brugia malayi 3267066 YP_198163.1 CDS rpsQ NC_006833.1 425799 426032 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(425799..426032) Wolbachia endosymbiont strain TRS of Brugia malayi 3267061 YP_198164.1 CDS Wbm0333 NC_006833.1 426025 >426231 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(426025..>426231) Wolbachia endosymbiont strain TRS of Brugia malayi 3267051 YP_198165.1 CDS rplP NC_006833.1 426240 426653 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(426240..426653) Wolbachia endosymbiont strain TRS of Brugia malayi 3267039 YP_198166.1 CDS rpsC NC_006833.1 426665 427285 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(426665..427285) Wolbachia endosymbiont strain TRS of Brugia malayi 3267022 YP_198167.1 CDS rplV NC_006833.1 427324 427674 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(427324..427674) Wolbachia endosymbiont strain TRS of Brugia malayi 3267029 YP_198168.1 CDS rpsS NC_006833.1 427680 427964 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(427680..427964) Wolbachia endosymbiont strain TRS of Brugia malayi 3267027 YP_198169.1 CDS rplB NC_006833.1 427968 428792 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(427968..428792) Wolbachia endosymbiont strain TRS of Brugia malayi 3267032 YP_198170.1 CDS rplW NC_006833.1 428794 429081 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(428794..429081) Wolbachia endosymbiont strain TRS of Brugia malayi 3267034 YP_198171.1 CDS rplD NC_006833.1 429078 429692 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(429078..429692) Wolbachia endosymbiont strain TRS of Brugia malayi 3266593 YP_198172.1 CDS rplC NC_006833.1 429695 430420 R binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 complement(429695..430420) Wolbachia endosymbiont strain TRS of Brugia malayi 3266591 YP_198173.1 CDS rpsJ NC_006833.1 430417 430782 R NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 complement(430417..430782) Wolbachia endosymbiont strain TRS of Brugia malayi 3266589 YP_198174.1 CDS Wbm0343 NC_006833.1 430782 431981 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(430782..431981) Wolbachia endosymbiont strain TRS of Brugia malayi 3266987 YP_198175.1 CDS Wbm0344 NC_006833.1 431993 434059 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(431993..434059) Wolbachia endosymbiont strain TRS of Brugia malayi 3266617 YP_198176.1 CDS Wbm0345 NC_006833.1 434081 434560 R binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(434081..434560) Wolbachia endosymbiont strain TRS of Brugia malayi 3266616 YP_198177.1 CDS rpsL NC_006833.1 434567 434941 R interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 complement(434567..434941) Wolbachia endosymbiont strain TRS of Brugia malayi 3266615 YP_198178.1 CDS Wbm0347 NC_006833.1 437115 437297 R hypothetical protein complement(437115..437297) Wolbachia endosymbiont strain TRS of Brugia malayi 3266611 YP_198179.1 CDS Wbm0348 NC_006833.1 438092 438889 R aminomethyltransferase related to GcvT complement(438092..438889) Wolbachia endosymbiont strain TRS of Brugia malayi 3267002 YP_198180.1 CDS groES NC_006833.1 439037 439327 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 439037..439327 Wolbachia endosymbiont strain TRS of Brugia malayi 3266725 YP_198181.1 CDS groEL NC_006833.1 439429 441081 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 439429..441081 Wolbachia endosymbiont strain TRS of Brugia malayi 3266722 YP_198182.1 CDS Wbm0351 NC_006833.1 441346 441849 D hypothetical protein 441346..441849 Wolbachia endosymbiont strain TRS of Brugia malayi 3266723 YP_198183.1 CDS Wbm0352 NC_006833.1 443923 445074 R outer membrane protein complement(443923..445074) Wolbachia endosymbiont strain TRS of Brugia malayi 3266568 YP_198184.1 CDS Wbm0353 NC_006833.1 445270 445476 R hypothetical protein complement(445270..445476) Wolbachia endosymbiont strain TRS of Brugia malayi 3266578 YP_198185.1 CDS Wbm0355 NC_006833.1 446963 447433 R dUTPase complement(446963..447433) Wolbachia endosymbiont strain TRS of Brugia malayi 3266545 YP_198186.1 CDS Wbm0356 NC_006833.1 447500 448441 R acetylglutamate kinase complement(447500..448441) Wolbachia endosymbiont strain TRS of Brugia malayi 3266544 YP_198187.1 CDS engB NC_006833.1 448416 448976 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(448416..448976) Wolbachia endosymbiont strain TRS of Brugia malayi 3266543 YP_198188.1 CDS prfA NC_006833.1 449132 450211 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 449132..450211 Wolbachia endosymbiont strain TRS of Brugia malayi 3266542 YP_198189.1 CDS Wbm0359 NC_006833.1 450228 451394 R major facilitator superfamily permease complement(450228..451394) Wolbachia endosymbiont strain TRS of Brugia malayi 3266541 YP_198190.1 CDS Wbm0360 NC_006833.1 452600 452980 D hypothetical protein 452600..452980 Wolbachia endosymbiont strain TRS of Brugia malayi 3266557 YP_198191.1 CDS alaS NC_006833.1 453110 455737 D Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 453110..455737 Wolbachia endosymbiont strain TRS of Brugia malayi 3266885 YP_198192.1 CDS Wbm0362 NC_006833.1 455742 458399 R hypothetical protein complement(455742..458399) Wolbachia endosymbiont strain TRS of Brugia malayi 3266880 YP_198193.1 CDS ileS NC_006833.1 458460 461864 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase complement(458460..461864) Wolbachia endosymbiont strain TRS of Brugia malayi 3266894 YP_198194.1 CDS Wbm0364 NC_006833.1 461929 463275 R catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase complement(461929..463275) Wolbachia endosymbiont strain TRS of Brugia malayi 3266893 YP_198195.1 CDS Wbm0365 NC_006833.1 463878 464516 R EndoIII-related endonuclease complement(463878..464516) Wolbachia endosymbiont strain TRS of Brugia malayi 3266643 YP_198196.1 CDS Wbm0366 NC_006833.1 464708 465211 R hypothetical protein complement(464708..465211) Wolbachia endosymbiont strain TRS of Brugia malayi 3266641 YP_198197.1 CDS Wbm0367 NC_006833.1 465918 467345 R catalyzes the formation of 2-oxoglutarate from isocitrate; isocitrate dehydrogenase complement(465918..467345) Wolbachia endosymbiont strain TRS of Brugia malayi 3266652 YP_198198.1 CDS Wbm0368 NC_006833.1 467626 467856 D hypothetical protein 467626..467856 Wolbachia endosymbiont strain TRS of Brugia malayi 3266683 YP_198199.1 CDS Wbm0369 NC_006833.1 468086 468844 D phosphatidylglycerophosphatase A, PgpA 468086..468844 Wolbachia endosymbiont strain TRS of Brugia malayi 3266704 YP_198200.1 CDS glyQ NC_006833.1 468889 469728 D glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 468889..469728 Wolbachia endosymbiont strain TRS of Brugia malayi 3266656 YP_198201.1 CDS Wbm0371 NC_006833.1 469732 471840 D glycyl-tRNA synthetase, beta subunit 469732..471840 Wolbachia endosymbiont strain TRS of Brugia malayi 3267089 YP_198202.1 CDS uvrC NC_006833.1 471825 473645 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 471825..473645 Wolbachia endosymbiont strain TRS of Brugia malayi 3266253 YP_198203.1 CDS Wbm0373 NC_006833.1 476052 477047 R catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase complement(476052..477047) Wolbachia endosymbiont strain TRS of Brugia malayi 3266870 YP_198204.1 CDS Wbm0374 NC_006833.1 477156 478109 R hypothetical protein complement(477156..478109) Wolbachia endosymbiont strain TRS of Brugia malayi 3266863 YP_198205.2 CDS Wbm0375 NC_006833.1 478197 479222 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H complement(478197..479222) Wolbachia endosymbiont strain TRS of Brugia malayi 3267137 YP_198206.1 CDS Wbm0376 NC_006833.1 479206 481254 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G complement(479206..481254) Wolbachia endosymbiont strain TRS of Brugia malayi 3266679 YP_198207.1 CDS Wbm0377 NC_006833.1 481268 481480 R hypothetical protein complement(481268..481480) Wolbachia endosymbiont strain TRS of Brugia malayi 3266929 YP_198208.1 CDS Wbm0378 NC_006833.1 482448 482711 R hypothetical protein complement(482448..482711) Wolbachia endosymbiont strain TRS of Brugia malayi 3266244 YP_198209.1 CDS Wbm0379 NC_006833.1 482819 483283 R cardiolipin synthase complement(482819..483283) Wolbachia endosymbiont strain TRS of Brugia malayi 3266856 YP_198210.1 CDS Wbm0380 NC_006833.1 483387 484874 R 3-polyprenyl-4-hydroxybenzoate decarboxylase, UbiD complement(483387..484874) Wolbachia endosymbiont strain TRS of Brugia malayi 3266858 YP_198211.1 CDS Wbm0381 NC_006833.1 484901 485242 R hypothetical protein complement(484901..485242) Wolbachia endosymbiont strain TRS of Brugia malayi 3266859 YP_198212.1 CDS Wbm0382 NC_006833.1 486677 487435 D protein-disulfide isomerase 486677..487435 Wolbachia endosymbiont strain TRS of Brugia malayi 3266689 YP_198213.1 CDS Wbm0383 NC_006833.1 490219 491115 R Co/Zn/Cd efflux system component complement(490219..491115) Wolbachia endosymbiont strain TRS of Brugia malayi 3266703 YP_198214.1 CDS Wbm0384 NC_006833.1 491487 493928 D extracellular metallopeptidase 491487..493928 Wolbachia endosymbiont strain TRS of Brugia malayi 3266562 YP_198215.1 CDS pyrB NC_006833.1 494038 494934 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit complement(494038..494934) Wolbachia endosymbiont strain TRS of Brugia malayi 3266563 YP_198216.1 CDS Wbm0386 NC_006833.1 496430 496729 D XRE family transcriptional regulator 496430..496729 Wolbachia endosymbiont strain TRS of Brugia malayi 3266564 YP_198217.1 CDS Wbm0387 NC_006833.1 496792 497220 D DNA-directed RNA polymerase subunit omega, RpoZ 496792..497220 Wolbachia endosymbiont strain TRS of Brugia malayi 3266567 YP_198218.1 CDS Wbm0388 NC_006833.1 497258 497500 D hypothetical protein 497258..497500 Wolbachia endosymbiont strain TRS of Brugia malayi 3266572 YP_198219.1 CDS Wbm0389 NC_006833.1 497507 497794 D subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; putative monovalent cation/H+ antiporter subunit G 497507..497794 Wolbachia endosymbiont strain TRS of Brugia malayi 3266573 YP_198220.1 CDS Wbm0390 NC_006833.1 497796 498323 D subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; putative monovalent cation/H+ antiporter subunit B 497796..498323 Wolbachia endosymbiont strain TRS of Brugia malayi 3266575 YP_198221.1 CDS Wbm0391 NC_006833.1 498316 498732 D subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; putative monovalent cation/H+ antiporter subunit B 498316..498732 Wolbachia endosymbiont strain TRS of Brugia malayi 3266576 YP_198222.1 CDS Wbm0392 NC_006833.1 498732 499058 D subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; putative monovalent cation/H+ antiporter subunit C 498732..499058 Wolbachia endosymbiont strain TRS of Brugia malayi 3267010 YP_198223.1 CDS Wbm0393 NC_006833.1 499181 501130 D DNA-directed RNA polymerase sigma 70 subunit, RpoD 499181..501130 Wolbachia endosymbiont strain TRS of Brugia malayi 3267011 YP_198224.1 CDS Wbm0394 NC_006833.1 501555 502013 R ankyrin repeat-containing protein complement(501555..502013) Wolbachia endosymbiont strain TRS of Brugia malayi 3267020 YP_198225.1 CDS sucA NC_006833.1 503366 506029 R SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component complement(503366..506029) Wolbachia endosymbiont strain TRS of Brugia malayi 3266428 YP_198226.1 CDS mutL NC_006833.1 507716 509602 R This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein complement(507716..509602) Wolbachia endosymbiont strain TRS of Brugia malayi 3266243 YP_198227.1 CDS Wbm0397 NC_006833.1 509607 510110 R phosphoribosylcarboxyaminoimidazole (NCAIR) mutase, PurE complement(509607..510110) Wolbachia endosymbiont strain TRS of Brugia malayi 3267072 YP_198228.1 CDS Wbm0398 NC_006833.1 511094 512125 R ABC-type Fe3+ transport system, periplasmic component complement(511094..512125) Wolbachia endosymbiont strain TRS of Brugia malayi 3267052 YP_198229.1 CDS Wbm0399 NC_006833.1 512255 513532 R hypothetical protein complement(512255..513532) Wolbachia endosymbiont strain TRS of Brugia malayi 3267024 YP_198230.1 CDS ppnK NC_006833.1 513628 514422 R catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase complement(513628..514422) Wolbachia endosymbiont strain TRS of Brugia malayi 3267004 YP_198231.1 CDS Wbm0401 NC_006833.1 514454 514666 R ribosomal protein L31 complement(514454..514666) Wolbachia endosymbiont strain TRS of Brugia malayi 3266891 YP_198232.1 CDS Wbm0402 NC_006833.1 514795 515775 D (acyl-carrier-protein) S-malonyltransferase, FabD 514795..515775 Wolbachia endosymbiont strain TRS of Brugia malayi 3266848 YP_198233.1 CDS Wbm0403 NC_006833.1 515831 517336 R catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase complement(515831..517336) Wolbachia endosymbiont strain TRS of Brugia malayi 3266850 YP_198234.1 CDS Wbm0404 NC_006833.1 520933 521256 D hypothetical protein 520933..521256 Wolbachia endosymbiont strain TRS of Brugia malayi 3266692 YP_198235.1 CDS Wbm0405 NC_006833.1 523904 526606 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 523904..526606 Wolbachia endosymbiont strain TRS of Brugia malayi 3266777 YP_198236.1 CDS Wbm0406 NC_006833.1 526711 527313 D Rieske Fe-S protein 526711..527313 Wolbachia endosymbiont strain TRS of Brugia malayi 3266906 YP_198237.1 CDS ksgA NC_006833.1 527841 528626 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(527841..528626) Wolbachia endosymbiont strain TRS of Brugia malayi 3266268 YP_198238.1 CDS Wbm0408 NC_006833.1 529449 530150 D Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 529449..530150 Wolbachia endosymbiont strain TRS of Brugia malayi 3266638 YP_198239.1 CDS Wbm0409 NC_006833.1 530282 531499 D 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 530282..531499 Wolbachia endosymbiont strain TRS of Brugia malayi 3267046 YP_198240.1 CDS Wbm0410 NC_006833.1 534696 535193 R hypothetical protein complement(534696..535193) Wolbachia endosymbiont strain TRS of Brugia malayi 3266935 YP_198241.1 CDS Wbm0411 NC_006833.1 537214 538767 R AICAR transformylase/IMP cyclohydrolase PurH complement(537214..538767) Wolbachia endosymbiont strain TRS of Brugia malayi 3266534 YP_198242.1 CDS hisS NC_006833.1 538874 540115 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(538874..540115) Wolbachia endosymbiont strain TRS of Brugia malayi 3266962 YP_198243.1 CDS Wbm0413 NC_006833.1 540112 540684 R NifU family protein complement(540112..540684) Wolbachia endosymbiont strain TRS of Brugia malayi 3267087 YP_198244.1 CDS Wbm0414 NC_006833.1 541171 542052 R hypothetical protein complement(541171..542052) Wolbachia endosymbiont strain TRS of Brugia malayi 3266924 YP_198245.1 CDS Wbm0415 NC_006833.1 542160 542528 R glutaredoxin complement(542160..542528) Wolbachia endosymbiont strain TRS of Brugia malayi 3266452 YP_198246.1 CDS Wbm0416 NC_006833.1 542599 543627 D FAD synthase 542599..543627 Wolbachia endosymbiont strain TRS of Brugia malayi 3266490 YP_198247.1 CDS Wbm0417 NC_006833.1 543624 544088 D lipoprotein signal peptidase 543624..544088 Wolbachia endosymbiont strain TRS of Brugia malayi 3266736 YP_198248.1 CDS Wbm0418 NC_006833.1 544137 545477 D Zn-dependent peptidase 544137..545477 Wolbachia endosymbiont strain TRS of Brugia malayi 3266734 YP_198249.1 CDS Wbm0419 NC_006833.1 545464 546774 D Zn-dependent peptidase 545464..546774 Wolbachia endosymbiont strain TRS of Brugia malayi 3266978 YP_198250.1 CDS Wbm0420 NC_006833.1 547672 548253 R folate-dependent phosphoribosylglycinamide formyltransferase PurN complement(547672..548253) Wolbachia endosymbiont strain TRS of Brugia malayi 3266951 YP_198251.2 CDS Wbm0421 NC_006833.1 549239 549760 R subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; putative monovalent cation/H+ antiporter subunit E complement(549239..549760) Wolbachia endosymbiont strain TRS of Brugia malayi 3266299 YP_198252.1 CDS Wbm0422 NC_006833.1 551266 551535 D hypothetical protein 551266..551535 Wolbachia endosymbiont strain TRS of Brugia malayi 3266459 YP_198253.1 CDS Wbm0423 NC_006833.1 551761 552336 R membrane protein complement(551761..552336) Wolbachia endosymbiont strain TRS of Brugia malayi 3267038 YP_198254.1 CDS Wbm0424 NC_006833.1 552576 553952 R Na+/alanine symporter complement(552576..553952) Wolbachia endosymbiont strain TRS of Brugia malayi 3266370 YP_198255.1 CDS Wbm0425 NC_006833.1 555379 556149 R phosphatidylserine synthase complement(555379..556149) Wolbachia endosymbiont strain TRS of Brugia malayi 3266465 YP_198256.1 CDS Wbm0426 NC_006833.1 556146 556799 R catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase complement(556146..556799) Wolbachia endosymbiont strain TRS of Brugia malayi 3266790 YP_198257.1 CDS recA NC_006833.1 557080 558147 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(557080..558147) Wolbachia endosymbiont strain TRS of Brugia malayi 3266793 YP_198258.1 CDS truA NC_006833.1 558367 559116 D mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 558367..559116 Wolbachia endosymbiont strain TRS of Brugia malayi 3266792 YP_198259.1 CDS Wbm0429 NC_006833.1 559126 560307 R DNA polymerase III beta clamp subunit complement(559126..560307) Wolbachia endosymbiont strain TRS of Brugia malayi 3266217 YP_198260.1 CDS Wbm0430 NC_006833.1 560403 560900 R hypothetical protein complement(560403..560900) Wolbachia endosymbiont strain TRS of Brugia malayi 3266579 YP_198261.1 CDS Wbm0431 NC_006833.1 560893 561786 R DNA-directed RNA polymerase sigma 32 subunit complement(560893..561786) Wolbachia endosymbiont strain TRS of Brugia malayi 3266580 YP_198262.1 CDS Wbm0432 NC_006833.1 562071 562793 R Outer surface protein Wsp complement(562071..562793) Wolbachia endosymbiont strain TRS of Brugia malayi 3266574 YP_198263.1 CDS Wbm0433 NC_006833.1 563623 563955 R hypothetical protein complement(563623..563955) Wolbachia endosymbiont strain TRS of Brugia malayi 3266684 YP_198264.1 CDS Wbm0434 NC_006833.1 563959 565443 R DNA polymerase III, gamma/tau subunit complement(563959..565443) Wolbachia endosymbiont strain TRS of Brugia malayi 3266728 YP_198265.1 CDS Wbm0435 NC_006833.1 565886 566539 D glutathione S-transferase 565886..566539 Wolbachia endosymbiont strain TRS of Brugia malayi 3266729 YP_198266.1 CDS Wbm0436 NC_006833.1 566541 567191 R O-methyltransferase complement(566541..567191) Wolbachia endosymbiont strain TRS of Brugia malayi 3266535 YP_198267.1 CDS Wbm0437 NC_006833.1 567441 567719 D hypothetical protein 567441..567719 Wolbachia endosymbiont strain TRS of Brugia malayi 3266677 YP_198268.1 CDS Wbm0438 NC_006833.1 567748 568452 R protein-disulfide isomerase complement(567748..568452) Wolbachia endosymbiont strain TRS of Brugia malayi 3266678 YP_198269.1 CDS Wbm0439 NC_006833.1 568502 569077 R oligoketide cyclase/lipid transport protein complement(568502..569077) Wolbachia endosymbiont strain TRS of Brugia malayi 3266849 YP_198270.1 CDS Wbm0440 NC_006833.1 569265 569855 D ABC-type transport system involved in resistance to organic solvents, auxiliary component 569265..569855 Wolbachia endosymbiont strain TRS of Brugia malayi 3266851 YP_198271.1 CDS Wbm0441 NC_006833.1 571117 572322 D catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 571117..572322 Wolbachia endosymbiont strain TRS of Brugia malayi 3266701 YP_198272.1 CDS Wbm0442 NC_006833.1 573673 574389 D tellurium resistance protein TerC 573673..574389 Wolbachia endosymbiont strain TRS of Brugia malayi 3266476 YP_198273.1 CDS guaA NC_006833.1 574391 575953 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(574391..575953) Wolbachia endosymbiont strain TRS of Brugia malayi 3266767 YP_198274.1 CDS Wbm0444 NC_006833.1 576293 576484 R hypothetical protein complement(576293..576484) Wolbachia endosymbiont strain TRS of Brugia malayi 3266755 YP_198275.1 CDS gltX NC_006833.1 577277 578599 D Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 577277..578599 Wolbachia endosymbiont strain TRS of Brugia malayi 3266896 YP_198276.1 CDS Wbm0446 NC_006833.1 579764 581095 R dihydroorotase, PyrC complement(579764..581095) Wolbachia endosymbiont strain TRS of Brugia malayi 3266338 YP_198277.1 CDS Wbm0447 NC_006833.1 581536 584862 D ankyrin repeat-containing protein 581536..584862 Wolbachia endosymbiont strain TRS of Brugia malayi 3266328 YP_198278.1 CDS sdhA NC_006833.1 584834 586639 R part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit complement(584834..586639) Wolbachia endosymbiont strain TRS of Brugia malayi 3266329 YP_198279.1 CDS dapD NC_006833.1 587290 588120 D catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 587290..588120 Wolbachia endosymbiont strain TRS of Brugia malayi 3266322 YP_198280.1 CDS Wbm0450 NC_006833.1 588141 588413 R hypothetical protein complement(588141..588413) Wolbachia endosymbiont strain TRS of Brugia malayi 3266273 YP_198281.1 CDS Wbm0451 NC_006833.1 588414 588797 R hypothetical protein complement(588414..588797) Wolbachia endosymbiont strain TRS of Brugia malayi 3266418 YP_198282.1 CDS Wbm0452 NC_006833.1 588943 590109 D SAM-dependent methyltransferase 588943..590109 Wolbachia endosymbiont strain TRS of Brugia malayi 3266409 YP_198283.1 CDS gltX NC_006833.1 590443 591804 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(590443..591804) Wolbachia endosymbiont strain TRS of Brugia malayi 3266385 YP_198284.1 CDS Wbm0454 NC_006833.1 591965 592702 D hypothetical protein 591965..592702 Wolbachia endosymbiont strain TRS of Brugia malayi 3266250 YP_198285.1 CDS Wbm0455 NC_006833.1 592751 594730 D Acetyl/propionyl-CoA carboxylase, alpha subunit 592751..594730 Wolbachia endosymbiont strain TRS of Brugia malayi 3266453 YP_198286.1 CDS Wbm0456 NC_006833.1 594713 595720 R hypothetical protein complement(594713..595720) Wolbachia endosymbiont strain TRS of Brugia malayi 3267057 YP_198287.1 CDS Wbm0457 NC_006833.1 597316 597792 R F0F1-type ATP synthase, subunit b complement(597316..597792) Wolbachia endosymbiont strain TRS of Brugia malayi 3267054 YP_198288.1 CDS Wbm0458 NC_006833.1 597801 598280 R F0F1-type ATP synthase, subunit b complement(597801..598280) Wolbachia endosymbiont strain TRS of Brugia malayi 3266998 YP_198289.1 CDS Wbm0459 NC_006833.1 598284 598511 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(598284..598511) Wolbachia endosymbiont strain TRS of Brugia malayi 3266865 YP_198290.1 CDS Wbm0460 NC_006833.1 598572 599297 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(598572..599297) Wolbachia endosymbiont strain TRS of Brugia malayi 3266866 YP_198291.1 CDS pheT NC_006833.1 600381 602759 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 600381..602759 Wolbachia endosymbiont strain TRS of Brugia malayi 3266867 YP_198292.1 CDS Wbm0462 NC_006833.1 602761 603693 R tRNA-dihydrouridine synthase complement(602761..603693) Wolbachia endosymbiont strain TRS of Brugia malayi 3266396 YP_198293.1 CDS Wbm0463 NC_006833.1 603702 605033 R membrane-associated or secreted protein complement(603702..605033) Wolbachia endosymbiont strain TRS of Brugia malayi 3266266 YP_198294.1 CDS Wbm0464 NC_006833.1 605187 606464 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 605187..606464 Wolbachia endosymbiont strain TRS of Brugia malayi 3266267 YP_198295.1 CDS Wbm0465 NC_006833.1 606499 607770 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 606499..607770 Wolbachia endosymbiont strain TRS of Brugia malayi 3266500 YP_198296.1 CDS Wbm0466 NC_006833.1 609123 609308 D hypothetical protein 609123..609308 Wolbachia endosymbiont strain TRS of Brugia malayi 3266485 YP_198297.1 CDS Wbm0467 NC_006833.1 609641 609826 D hypothetical protein 609641..609826 Wolbachia endosymbiont strain TRS of Brugia malayi 3266460 YP_198298.1 CDS Wbm0468 NC_006833.1 609828 610034 R hypothetical protein complement(609828..610034) Wolbachia endosymbiont strain TRS of Brugia malayi 3267060 YP_198299.1 CDS Wbm0469 NC_006833.1 611489 613123 R metallo-beta-lactamase superfamily hydrolase complement(611489..613123) Wolbachia endosymbiont strain TRS of Brugia malayi 3266974 YP_198300.1 CDS Wbm0470 NC_006833.1 613360 614172 D enoyl-[acyl-carrier-protein] reductase (NADH) 613360..614172 Wolbachia endosymbiont strain TRS of Brugia malayi 3266932 YP_198301.1 CDS Wbm0471 NC_006833.1 614250 614732 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 614250..614732 Wolbachia endosymbiont strain TRS of Brugia malayi 3266626 YP_198302.1 CDS thrS NC_006833.1 614874 616772 D catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 614874..616772 Wolbachia endosymbiont strain TRS of Brugia malayi 3266387 YP_198303.1 CDS Wbm0473 NC_006833.1 616790 617299 D translation initiation factor 3, IF-3 616790..617299 Wolbachia endosymbiont strain TRS of Brugia malayi 3266388 YP_198304.1 CDS Wbm0474 NC_006833.1 618412 619686 R part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F complement(618412..619686) Wolbachia endosymbiont strain TRS of Brugia malayi 3266405 YP_198305.1 CDS Wbm0475 NC_006833.1 622220 622993 R Short-chain alcohol dehydrogenase family enzyme complement(622220..622993) Wolbachia endosymbiont strain TRS of Brugia malayi 3266690 YP_198306.1 CDS Wbm0476 NC_006833.1 622980 623804 R tRNA processing exoribonuclease BN complement(622980..623804) Wolbachia endosymbiont strain TRS of Brugia malayi 3266732 YP_198307.1 CDS Wbm0477 NC_006833.1 625051 625239 R hypothetical protein complement(625051..625239) Wolbachia endosymbiont strain TRS of Brugia malayi 3266337 YP_198308.1 CDS Wbm0478 NC_006833.1 625266 625514 R hypothetical protein complement(625266..625514) Wolbachia endosymbiont strain TRS of Brugia malayi 3266251 YP_198309.1 CDS Wbm0479 NC_006833.1 625612 625836 R hypothetical protein complement(625612..625836) Wolbachia endosymbiont strain TRS of Brugia malayi 3266706 YP_198310.1 CDS Wbm0480 NC_006833.1 626162 627517 D phosphomannomutase 626162..627517 Wolbachia endosymbiont strain TRS of Brugia malayi 3266950 YP_198311.1 CDS Wbm0481 NC_006833.1 627663 628826 R membrane-bound protoheme IX biogenesis protein, HemY complement(627663..628826) Wolbachia endosymbiont strain TRS of Brugia malayi 3266787 YP_198312.1 CDS Wbm0482 NC_006833.1 628877 629611 R hypothetical protein complement(628877..629611) Wolbachia endosymbiont strain TRS of Brugia malayi 3266788 YP_198313.1 CDS Wbm0483 NC_006833.1 629604 630761 R ABC-type transport system, involved in lipoprotein release, permease component complement(629604..630761) Wolbachia endosymbiont strain TRS of Brugia malayi 3267015 YP_198314.1 CDS Wbm0484 NC_006833.1 632376 633641 R hypothetical protein complement(632376..633641) Wolbachia endosymbiont strain TRS of Brugia malayi 3266758 YP_198315.1 CDS Wbm0485 NC_006833.1 633727 634092 R succinate dehydrogenase subunit D sdhD, hydrophobic membrane anchor protein complement(633727..634092) Wolbachia endosymbiont strain TRS of Brugia malayi 3266753 YP_198316.1 CDS Wbm0486 NC_006833.1 634089 634466 R succinate dehydrogenase subunit C sdhC complement(634089..634466) Wolbachia endosymbiont strain TRS of Brugia malayi 3266955 YP_198317.1 CDS Wbm0487 NC_006833.1 636292 636837 D hypothetical protein 636292..636837 Wolbachia endosymbiont strain TRS of Brugia malayi 3266526 YP_198318.1 CDS Wbm0488 NC_006833.1 637371 637871 R Smr/mutS family protein complement(637371..637871) Wolbachia endosymbiont strain TRS of Brugia malayi 3266361 YP_198319.1 CDS Wbm0489 NC_006833.1 637964 638740 D rRNA methylase 637964..638740 Wolbachia endosymbiont strain TRS of Brugia malayi 3266406 YP_198320.1 CDS Wbm0490 NC_006833.1 638808 639530 D integral membrane protein, interacts with FtsH 638808..639530 Wolbachia endosymbiont strain TRS of Brugia malayi 3266407 YP_198321.1 CDS Wbm0491 NC_006833.1 639531 640070 D involved in the insertion of copper into subunit I of cytochrome C oxidase; cytochrome C oxidase assembly protein 639531..640070 Wolbachia endosymbiont strain TRS of Brugia malayi 3267058 YP_198322.1 CDS Wbm0492 NC_006833.1 640843 642333 R UDP-N-acetylmuramyl tripeptide synthase complement(640843..642333) Wolbachia endosymbiont strain TRS of Brugia malayi 3266475 YP_198323.1 CDS Wbm0493 NC_006833.1 642308 643549 R cystathionine beta-lyase complement(642308..643549) Wolbachia endosymbiont strain TRS of Brugia malayi 3266429 YP_198324.1 CDS Wbm0494 NC_006833.1 643556 643840 R stress-induced morphogen, BolA complement(643556..643840) Wolbachia endosymbiont strain TRS of Brugia malayi 3266918 YP_198325.1 CDS dnaK NC_006833.1 643913 645820 R heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK complement(643913..645820) Wolbachia endosymbiont strain TRS of Brugia malayi 3266941 YP_198326.1 CDS Wbm0496 NC_006833.1 645908 647680 R ribonuclease G and E complement(645908..647680) Wolbachia endosymbiont strain TRS of Brugia malayi 3266943 YP_198327.1 CDS rpmG NC_006833.1 647842 648042 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 647842..648042 Wolbachia endosymbiont strain TRS of Brugia malayi 3266944 YP_198328.1 CDS Wbm0498 NC_006833.1 648067 648348 D XRE family transcriptional regulator 648067..648348 Wolbachia endosymbiont strain TRS of Brugia malayi 3266317 YP_198329.1 CDS Wbm0499 NC_006833.1 649784 653122 D DNA polymerase III alpha subunit 649784..653122 Wolbachia endosymbiont strain TRS of Brugia malayi 3266680 YP_198330.1 CDS rpsF NC_006833.1 653171 653953 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 653171..653953 Wolbachia endosymbiont strain TRS of Brugia malayi 3267128 YP_198331.1 CDS rpsR NC_006833.1 653953 654228 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 653953..654228 Wolbachia endosymbiont strain TRS of Brugia malayi 3266731 YP_198332.1 CDS rplI NC_006833.1 654236 654796 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 654236..654796 Wolbachia endosymbiont strain TRS of Brugia malayi 3266899 YP_198333.1 CDS Wbm0503 NC_006833.1 654903 656195 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 654903..656195 Wolbachia endosymbiont strain TRS of Brugia malayi 3266900 YP_198334.1 CDS fumC NC_006833.1 658457 659848 D class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 658457..659848 Wolbachia endosymbiont strain TRS of Brugia malayi 3266437 YP_198335.1 CDS Wbm0505 NC_006833.1 660161 660538 R hypothetical protein complement(660161..660538) Wolbachia endosymbiont strain TRS of Brugia malayi 3266740 YP_198336.1 CDS Wbm0506 NC_006833.1 660522 661571 R outer membrane protein complement(660522..661571) Wolbachia endosymbiont strain TRS of Brugia malayi 3266705 YP_198337.1 CDS Wbm0507 NC_006833.1 661575 661934 R ferredoxin complement(661575..661934) Wolbachia endosymbiont strain TRS of Brugia malayi 3266606 YP_198338.1 CDS Wbm0508 NC_006833.1 662055 663551 D UDP-N-acetylmuramoylalanine-D-glutamate ligase 662055..663551 Wolbachia endosymbiont strain TRS of Brugia malayi 3266271 YP_198339.1 CDS Wbm0509 NC_006833.1 663564 664163 D TetR family transcriptional regulator 663564..664163 Wolbachia endosymbiont strain TRS of Brugia malayi 3266272 YP_198340.1 CDS Wbm0510 NC_006833.1 664252 664494 D hypothetical protein 664252..664494 Wolbachia endosymbiont strain TRS of Brugia malayi 3267068 YP_198341.1 CDS Wbm0511 NC_006833.1 664926 665135 D hypothetical protein 664926..665135 Wolbachia endosymbiont strain TRS of Brugia malayi 3266436 YP_198342.2 CDS carB NC_006833.1 667148 670402 R four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit complement(667148..670402) Wolbachia endosymbiont strain TRS of Brugia malayi 3266439 YP_198343.1 CDS Wbm0513 NC_006833.1 672461 672643 R hypothetical protein complement(672461..672643) Wolbachia endosymbiont strain TRS of Brugia malayi 3266983 YP_198344.1 CDS Wbm0514 NC_006833.1 672846 673055 D hypothetical protein 672846..673055 Wolbachia endosymbiont strain TRS of Brugia malayi 3266289 YP_198345.1 CDS Wbm0515 NC_006833.1 673098 673283 D hypothetical protein 673098..673283 Wolbachia endosymbiont strain TRS of Brugia malayi 3266290 YP_198346.1 CDS Wbm0516 NC_006833.1 674181 674717 R hypothetical protein complement(674181..674717) Wolbachia endosymbiont strain TRS of Brugia malayi 3266530 YP_198347.1 CDS Wbm0517 NC_006833.1 674882 675331 D nitroreductase 674882..675331 Wolbachia endosymbiont strain TRS of Brugia malayi 3266527 YP_198348.1 CDS Wbm0518 NC_006833.1 675417 676196 D diaminopimelate epimerase 675417..676196 Wolbachia endosymbiont strain TRS of Brugia malayi 3267088 YP_198349.1 CDS Wbm0519 NC_006833.1 676204 677091 R succinyl-CoA synthetase, alpha subunit complement(676204..677091) Wolbachia endosymbiont strain TRS of Brugia malayi 3267075 YP_198350.1 CDS sucC NC_006833.1 677095 678255 R catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta complement(677095..678255) Wolbachia endosymbiont strain TRS of Brugia malayi 3266354 YP_198351.1 CDS rpsU NC_006833.1 678284 678484 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(678284..678484) Wolbachia endosymbiont strain TRS of Brugia malayi 3266310 YP_198352.1 CDS Wbm0522 NC_006833.1 680323 680541 R hypothetical protein complement(680323..680541) Wolbachia endosymbiont strain TRS of Brugia malayi 3266560 YP_198353.1 CDS Wbm0523 NC_006833.1 681027 681251 R hypothetical protein complement(681027..681251) Wolbachia endosymbiont strain TRS of Brugia malayi 3267091 YP_198354.1 CDS Wbm0524 NC_006833.1 681437 681628 R hypothetical protein complement(681437..681628) Wolbachia endosymbiont strain TRS of Brugia malayi 3267094 YP_198355.1 CDS Wbm0525 NC_006833.1 681709 682023 R hypothetical protein complement(681709..682023) Wolbachia endosymbiont strain TRS of Brugia malayi 3267096 YP_198356.1 CDS Wbm0526 NC_006833.1 682180 682389 R hypothetical protein complement(682180..682389) Wolbachia endosymbiont strain TRS of Brugia malayi 3266948 YP_198357.1 CDS Wbm0527 NC_006833.1 683292 684788 R IMP dehydrogenase, GuaB complement(683292..684788) Wolbachia endosymbiont strain TRS of Brugia malayi 3266949 YP_198358.1 CDS rho NC_006833.1 685594 687009 R An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho complement(685594..687009) Wolbachia endosymbiont strain TRS of Brugia malayi 3266783 YP_198359.1 CDS Wbm0529 NC_006833.1 687216 687806 R hypothetical protein complement(687216..687806) Wolbachia endosymbiont strain TRS of Brugia malayi 3266274 YP_198360.1 CDS Wbm0530 NC_006833.1 688142 689950 D parvulin-like peptidyl-prolyl isomerase, PPID 688142..689950 Wolbachia endosymbiont strain TRS of Brugia malayi 3266467 YP_198361.1 CDS rpsP NC_006833.1 690087 690407 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 690087..690407 Wolbachia endosymbiont strain TRS of Brugia malayi 3266468 YP_198362.1 CDS Wbm0532 NC_006833.1 690417 691403 D geranylgeranyl pyrophosphate synthase 690417..691403 Wolbachia endosymbiont strain TRS of Brugia malayi 3266510 YP_198363.1 CDS Wbm0533 NC_006833.1 691465 692013 D molecular chaperone GrpE (heat shock protein) 691465..692013 Wolbachia endosymbiont strain TRS of Brugia malayi 3266746 YP_198364.1 CDS Wbm0534 NC_006833.1 692059 693057 D tryptophanyl-tRNA synthetase 692059..693057 Wolbachia endosymbiont strain TRS of Brugia malayi 3266747 YP_198365.1 CDS ubiA NC_006833.1 694736 695602 R UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin; 4-hydroxybenzoate polyprenyltransferase complement(694736..695602) Wolbachia endosymbiont strain TRS of Brugia malayi 3266408 YP_198366.1 CDS Wbm0536 NC_006833.1 695606 695950 R ribosome-binding factor A complement(695606..695950) Wolbachia endosymbiont strain TRS of Brugia malayi 3266841 YP_198367.1 CDS infB NC_006833.1 695960 698293 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(695960..698293) Wolbachia endosymbiont strain TRS of Brugia malayi 3266645 YP_198368.1 CDS nusA NC_006833.1 698295 699857 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(698295..699857) Wolbachia endosymbiont strain TRS of Brugia malayi 3266646 YP_198369.1 CDS Wbm0539 NC_006833.1 703747 706887 R proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the proteins from this group do not and in addition appear to have a truncated C-terminal domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase complement(703747..706887) Wolbachia endosymbiont strain TRS of Brugia malayi 3266463 YP_198370.1 CDS Wbm0540 NC_006833.1 707027 709630 R Catalyzes the conversion of citrate to isocitrate; aconitate hydratase complement(707027..709630) Wolbachia endosymbiont strain TRS of Brugia malayi 3266426 YP_198371.1 CDS Wbm0541 NC_006833.1 709789 710292 R molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB complement(709789..710292) Wolbachia endosymbiont strain TRS of Brugia malayi 3266427 YP_198372.1 CDS Wbm0542 NC_006833.1 710451 711107 D hypothetical protein 710451..711107 Wolbachia endosymbiont strain TRS of Brugia malayi 3266533 YP_198373.1 CDS Wbm0543 NC_006833.1 711120 711815 D DNA polymerase III epsilon subunit 711120..711815 Wolbachia endosymbiont strain TRS of Brugia malayi 3266602 YP_198374.1 CDS Wbm0544 NC_006833.1 711860 712474 D hypothetical protein 711860..712474 Wolbachia endosymbiont strain TRS of Brugia malayi 3266603 YP_198375.1 CDS Wbm0545 NC_006833.1 713917 714216 R NADH:ubiquinone oxidoreductase 18 kDa subunit complement(713917..714216) Wolbachia endosymbiont strain TRS of Brugia malayi 3267105 YP_198376.1 CDS Wbm0546 NC_006833.1 714334 715014 D esterase 714334..715014 Wolbachia endosymbiont strain TRS of Brugia malayi 3266375 YP_198377.1 CDS Wbm0547 NC_006833.1 715020 715841 D nucleoside-diphosphate-sugar epimerase 715020..715841 Wolbachia endosymbiont strain TRS of Brugia malayi 3266260 YP_198378.1 CDS Wbm0548 NC_006833.1 720893 722944 R NAD-dependent DNA ligase, Lig complement(720893..722944) Wolbachia endosymbiont strain TRS of Brugia malayi 3267139 YP_198379.1 CDS Wbm0549 NC_006833.1 723146 723898 D acid phosphatase 723146..723898 Wolbachia endosymbiont strain TRS of Brugia malayi 3266667 YP_198380.1 CDS Wbm0550 NC_006833.1 724141 724350 R hypothetical protein complement(724141..724350) Wolbachia endosymbiont strain TRS of Brugia malayi 3266668 YP_198381.1 CDS Wbm0551 NC_006833.1 724848 727259 R ATP-dependent Lon protease complement(724848..727259) Wolbachia endosymbiont strain TRS of Brugia malayi 3266669 YP_198382.1 CDS clpX NC_006833.1 727275 728555 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(727275..728555) Wolbachia endosymbiont strain TRS of Brugia malayi 3266663 YP_198383.1 CDS clpP NC_006833.1 728555 729181 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(728555..729181) Wolbachia endosymbiont strain TRS of Brugia malayi 3266664 YP_198384.1 CDS Wbm0554 NC_006833.1 729193 730536 R FKBP-type peptidyl-prolyl cis-trans isomerase, TIG complement(729193..730536) Wolbachia endosymbiont strain TRS of Brugia malayi 3266320 YP_198385.1 CDS Wbm0555 NC_006833.1 730917 731507 D lipoprotein, OsmY ortholog 730917..731507 Wolbachia endosymbiont strain TRS of Brugia malayi 3266915 YP_198386.1 CDS Wbm0556 NC_006833.1 731584 732501 D catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 731584..732501 Wolbachia endosymbiont strain TRS of Brugia malayi 3266916 YP_198387.1 CDS Wbm0557 NC_006833.1 732486 733517 R UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase complement(732486..733517) Wolbachia endosymbiont strain TRS of Brugia malayi 3266953 YP_198388.1 CDS Wbm0558 NC_006833.1 733769 733981 D hypothetical protein 733769..733981 Wolbachia endosymbiont strain TRS of Brugia malayi 3266520 YP_198389.1 CDS Wbm0559 NC_006833.1 733983 735422 R dihydrolipoamide dehydrogenase E3 component complement(733983..735422) Wolbachia endosymbiont strain TRS of Brugia malayi 3266521 YP_198390.1 CDS Wbm0560 NC_006833.1 736435 737106 D PQQ-like beta-propeller repeat-containing protein 736435..737106 Wolbachia endosymbiont strain TRS of Brugia malayi 3266305 YP_198391.1 CDS Wbm0561 NC_006833.1 737099 738487 D dihydrolipoamide dehydrogenase E3 component 737099..738487 Wolbachia endosymbiont strain TRS of Brugia malayi 3266778 YP_198392.1 CDS Wbm0562 NC_006833.1 738490 739668 D integrase 738490..739668 Wolbachia endosymbiont strain TRS of Brugia malayi 3266779 YP_198393.1 CDS Wbm0563 NC_006833.1 740335 740574 R hypothetical protein complement(740335..740574) Wolbachia endosymbiont strain TRS of Brugia malayi 3266571 YP_198394.1 CDS Wbm0564 NC_006833.1 740740 740970 R hypothetical protein complement(740740..740970) Wolbachia endosymbiont strain TRS of Brugia malayi 3266685 YP_198395.1 CDS Wbm0565 NC_006833.1 740994 741335 R hypothetical protein complement(740994..741335) Wolbachia endosymbiont strain TRS of Brugia malayi 3266686 YP_198396.1 CDS Wbm0566 NC_006833.1 741449 742405 R thioredoxin reductase complement(741449..742405) Wolbachia endosymbiont strain TRS of Brugia malayi 3266868 YP_198397.1 CDS Wbm0567 NC_006833.1 742392 743006 R peroxiredoxin complement(742392..743006) Wolbachia endosymbiont strain TRS of Brugia malayi 3266852 YP_198398.1 CDS Wbm0568 NC_006833.1 743117 744322 R dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase complement(743117..744322) Wolbachia endosymbiont strain TRS of Brugia malayi 3266853 YP_198399.1 CDS Wbm0569 NC_006833.1 746774 747148 D ferredoxin 746774..747148 Wolbachia endosymbiont strain TRS of Brugia malayi 3266586 YP_198400.1 CDS ddl NC_006833.1 748388 749407 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 748388..749407 Wolbachia endosymbiont strain TRS of Brugia malayi 3266990 YP_198401.1 CDS Wbm0571 NC_006833.1 749408 750166 D cell division septal protein 749408..750166 Wolbachia endosymbiont strain TRS of Brugia malayi 3266991 YP_198402.1 CDS Wbm0572 NC_006833.1 751170 751481 R nucleoid DNA-binding protein complement(751170..751481) Wolbachia endosymbiont strain TRS of Brugia malayi 3266420 YP_198403.1 CDS rpsI NC_006833.1 751629 752075 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(751629..752075) Wolbachia endosymbiont strain TRS of Brugia malayi 3266422 YP_198404.1 CDS rplM NC_006833.1 752085 752543 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(752085..752543) Wolbachia endosymbiont strain TRS of Brugia malayi 3266423 YP_198405.1 CDS Wbm0575 NC_006833.1 752673 753908 D Outer membrane protein 752673..753908 Wolbachia endosymbiont strain TRS of Brugia malayi 3266840 YP_198406.1 CDS Wbm0576 NC_006833.1 753928 754296 D hypothetical protein 753928..754296 Wolbachia endosymbiont strain TRS of Brugia malayi 3266552 YP_198407.1 CDS Wbm0577 NC_006833.1 754520 755170 D 23S rRNA methylase 754520..755170 Wolbachia endosymbiont strain TRS of Brugia malayi 3266720 YP_198408.1 CDS Wbm0578 NC_006833.1 755188 755835 R ABC-type transport system involved in cytochrome c biogenesis, permease component complement(755188..755835) Wolbachia endosymbiont strain TRS of Brugia malayi 3266665 YP_198409.1 CDS Wbm0579 NC_006833.1 755942 756325 D DnaK suppressor protein 755942..756325 Wolbachia endosymbiont strain TRS of Brugia malayi 3266497 YP_198410.1 CDS gmk NC_006833.1 756340 756927 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(756340..756927) Wolbachia endosymbiont strain TRS of Brugia malayi 3266498 YP_198411.1 CDS Wbm0581 NC_006833.1 756979 758799 R pentapeptide repeat-containing protein complement(756979..758799) Wolbachia endosymbiont strain TRS of Brugia malayi 3266975 YP_198412.1 CDS Wbm0582 NC_006833.1 758774 760114 R ankyrin repeat-containing protein complement(758774..760114) Wolbachia endosymbiont strain TRS of Brugia malayi 3266909 YP_198413.1 CDS Wbm0583 NC_006833.1 760611 761126 R inorganic pyrophosphatase complement(760611..761126) Wolbachia endosymbiont strain TRS of Brugia malayi 3266577 YP_198414.1 CDS Wbm0584 NC_006833.1 761701 762192 R ubiquinone biosynthesis protein COQ7 complement(761701..762192) Wolbachia endosymbiont strain TRS of Brugia malayi 3267078 YP_198415.1 CDS Wbm0585 NC_006833.1 762206 762718 R disulfide bond formation protein DsbB complement(762206..762718) Wolbachia endosymbiont strain TRS of Brugia malayi 3267079 YP_198416.1 CDS engA NC_006833.1 762744 764156 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(762744..764156) Wolbachia endosymbiont strain TRS of Brugia malayi 3266461 YP_198417.1 CDS Wbm0587 NC_006833.1 764294 765346 D hypothetical protein 764294..765346 Wolbachia endosymbiont strain TRS of Brugia malayi 3266583 YP_198418.1 CDS Wbm0588 NC_006833.1 765454 766980 D Acetyl-CoA carboxylase, carboxyltransferase component 765454..766980 Wolbachia endosymbiont strain TRS of Brugia malayi 3266584 YP_198419.1 CDS Wbm0589 NC_006833.1 767236 768051 D formamidopyrimidine-DNA glycosylase 767236..768051 Wolbachia endosymbiont strain TRS of Brugia malayi 3267135 YP_198420.1 CDS Wbm0590 NC_006833.1 768732 769190 R hypothetical protein complement(768732..769190) Wolbachia endosymbiont strain TRS of Brugia malayi 3266855 YP_198421.1 CDS Wbm0591 NC_006833.1 772818 773606 D Type IV secretory pathway, VirB9 component 772818..773606 Wolbachia endosymbiont strain TRS of Brugia malayi 3266344 YP_198422.1 CDS Wbm0592 NC_006833.1 773630 775135 R subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone; putative monovalent cation/H+ antiporter subunit D complement(773630..775135) Wolbachia endosymbiont strain TRS of Brugia malayi 3266345 YP_198423.1 CDS Wbm0593 NC_006833.1 775225 776415 R queuine/archaeosine tRNA-ribosyltransferase complement(775225..776415) Wolbachia endosymbiont strain TRS of Brugia malayi 3266342 YP_198424.1 CDS Wbm0594 NC_006833.1 776416 776916 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E complement(776416..776916) Wolbachia endosymbiont strain TRS of Brugia malayi 3266343 YP_198425.1 CDS Wbm0595 NC_006833.1 779421 779753 D hypothetical protein 779421..779753 Wolbachia endosymbiont strain TRS of Brugia malayi 3266532 YP_198426.1 CDS Wbm0596 NC_006833.1 781215 781985 R response regulator complement(781215..781985) Wolbachia endosymbiont strain TRS of Brugia malayi 3266968 YP_198427.1 CDS Wbm0597 NC_006833.1 782308 783291 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 782308..783291 Wolbachia endosymbiont strain TRS of Brugia malayi 3266969 YP_198428.1 CDS Wbm0598 NC_006833.1 783873 784562 D acetyltransferase domain-containing protein 783873..784562 Wolbachia endosymbiont strain TRS of Brugia malayi 3266688 YP_198429.1 CDS Wbm0599 NC_006833.1 784618 785754 D PAS/PAC domain-containing protein 784618..785754 Wolbachia endosymbiont strain TRS of Brugia malayi 3266446 YP_198430.1 CDS sdhB NC_006833.1 785758 786546 R part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit complement(785758..786546) Wolbachia endosymbiont strain TRS of Brugia malayi 3266447 YP_198431.1 CDS Wbm0601 NC_006833.1 786640 787155 R metal-dependent hydrolase complement(786640..787155) Wolbachia endosymbiont strain TRS of Brugia malayi 3266331 YP_198432.1 CDS Wbm0602 NC_006833.1 787556 788746 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(787556..788746) Wolbachia endosymbiont strain TRS of Brugia malayi 3266907 YP_198433.1 CDS Wbm0603 NC_006833.1 789436 789936 R hypothetical protein complement(789436..789936) Wolbachia endosymbiont strain TRS of Brugia malayi 3266908 YP_198434.1 CDS Wbm0604 NC_006833.1 792082 792351 R hypothetical protein complement(792082..792351) Wolbachia endosymbiont strain TRS of Brugia malayi 3266359 YP_198435.1 CDS leuS NC_006833.1 792705 795302 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(792705..795302) Wolbachia endosymbiont strain TRS of Brugia malayi 3266996 YP_198436.1 CDS Wbm0606 NC_006833.1 795315 795932 R membrane protein related to metalloendopeptidase complement(795315..795932) Wolbachia endosymbiont strain TRS of Brugia malayi 3266997 YP_198437.1 CDS Wbm0607 NC_006833.1 796794 797051 D hypothetical protein 796794..797051 Wolbachia endosymbiont strain TRS of Brugia malayi 3266599 YP_198438.1 CDS Wbm0608 NC_006833.1 798226 798549 R thioredoxin, trx complement(798226..798549) Wolbachia endosymbiont strain TRS of Brugia malayi 3267019 YP_198439.1 CDS Wbm0609 NC_006833.1 798673 799293 R ribonuclease D complement(798673..799293) Wolbachia endosymbiont strain TRS of Brugia malayi 3266503 YP_198440.1 CDS Wbm0610 NC_006833.1 799640 800083 D hypothetical protein 799640..800083 Wolbachia endosymbiont strain TRS of Brugia malayi 3266399 YP_198441.1 CDS Wbm0611 NC_006833.1 800227 802260 D GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 800227..802260 Wolbachia endosymbiont strain TRS of Brugia malayi 3266294 YP_198442.1 CDS Wbm0612 NC_006833.1 802269 803936 D Xaa-Pro aminopeptidase 802269..803936 Wolbachia endosymbiont strain TRS of Brugia malayi 3266493 YP_198443.1 CDS Wbm0613 NC_006833.1 804060 804428 D hypothetical protein 804060..804428 Wolbachia endosymbiont strain TRS of Brugia malayi 3266494 YP_198444.1 CDS Wbm0614 NC_006833.1 804446 805426 R 3-oxoacyl-[acyl-carrier-protein] synthase III complement(804446..805426) Wolbachia endosymbiont strain TRS of Brugia malayi 3266384 YP_198445.1 CDS Wbm0615 NC_006833.1 805419 806456 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX complement(805419..806456) Wolbachia endosymbiont strain TRS of Brugia malayi 3266284 YP_198446.2 CDS rpmF NC_006833.1 806467 806649 R some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 complement(806467..806649) Wolbachia endosymbiont strain TRS of Brugia malayi 3266285 YP_198447.1 CDS Wbm0617 NC_006833.1 806891 807673 D ABC-type transport system involved in resistance to organic solvents, permease component 806891..807673 Wolbachia endosymbiont strain TRS of Brugia malayi 3266330 YP_198448.1 CDS Wbm0618 NC_006833.1 807666 808376 D ABC-type transport system involved in resistance to organic solvents, ATPase component 807666..808376 Wolbachia endosymbiont strain TRS of Brugia malayi 3266373 YP_198449.1 CDS Wbm0619 NC_006833.1 808398 808784 R CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE complement(808398..808784) Wolbachia endosymbiont strain TRS of Brugia malayi 3266374 YP_198450.1 CDS Wbm0620 NC_006833.1 808902 809813 R biotin-(acetyl-CoA carboxylase) ligase complement(808902..809813) Wolbachia endosymbiont strain TRS of Brugia malayi 3266662 YP_198451.1 CDS Wbm0621 NC_006833.1 809815 811212 R NADH:ubiquinone oxidoreductase chain N complement(809815..811212) Wolbachia endosymbiont strain TRS of Brugia malayi 3266660 YP_198452.1 CDS Wbm0622 NC_006833.1 811209 812651 R NADH:ubiquinone oxidoreductase chain M complement(811209..812651) Wolbachia endosymbiont strain TRS of Brugia malayi 3266661 YP_198453.1 CDS Wbm0623 NC_006833.1 812655 814511 R NADH:ubiquinone oxidoreductase chain L complement(812655..814511) Wolbachia endosymbiont strain TRS of Brugia malayi 3266654 YP_198454.1 CDS Wbm0624 NC_006833.1 814516 814824 R NADH:ubiquinone oxidoreductase chain K complement(814516..814824) Wolbachia endosymbiont strain TRS of Brugia malayi 3267043 YP_198455.1 CDS Wbm0625 NC_006833.1 814815 815348 R NADH:ubiquinone oxidoreductase chain J complement(814815..815348) Wolbachia endosymbiont strain TRS of Brugia malayi 3267044 YP_198456.1 CDS Wbm0626 NC_006833.1 816014 816331 D hypothetical protein 816014..816331 Wolbachia endosymbiont strain TRS of Brugia malayi 3266601 YP_198457.1 CDS Wbm0627 NC_006833.1 816754 816948 D hypothetical protein 816754..816948 Wolbachia endosymbiont strain TRS of Brugia malayi 3266522 YP_198458.1 CDS Wbm0628 NC_006833.1 817133 819049 D superfamily I DNA/RNA helicase 817133..819049 Wolbachia endosymbiont strain TRS of Brugia malayi 3266523 YP_198459.1 CDS Wbm0629 NC_006833.1 819501 820478 R NADPH:quinone reductase complement(819501..820478) Wolbachia endosymbiont strain TRS of Brugia malayi 3266875 YP_198460.1 CDS Wbm0630 NC_006833.1 822762 824228 R catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase complement(822762..824228) Wolbachia endosymbiont strain TRS of Brugia malayi 3266227 YP_198461.1 CDS Wbm0631 NC_006833.1 824287 824937 R protocatechuate 3,4-dioxygenase beta subunit complement(824287..824937) Wolbachia endosymbiont strain TRS of Brugia malayi 3267045 YP_198462.1 CDS rpmJ NC_006833.1 825475 825603 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 complement(825475..825603) Wolbachia endosymbiont strain TRS of Brugia malayi 3267047 YP_198463.1 CDS Wbm0633 NC_006833.1 825671 826489 R hypothetical protein complement(825671..826489) Wolbachia endosymbiont strain TRS of Brugia malayi 3267048 YP_198464.1 CDS Wbm0634 NC_006833.1 827123 827833 D ABC-type transport system involved in cytochrome c biogenesis, permease component 827123..827833 Wolbachia endosymbiont strain TRS of Brugia malayi 3266628 YP_198465.1 CDS Wbm0635 NC_006833.1 828913 830961 R RecG-like helicase complement(828913..830961) Wolbachia endosymbiont strain TRS of Brugia malayi 3266495 YP_198466.1 CDS Wbm0636 NC_006833.1 832084 832977 R tRNA delta(2)-isopentenylpyrophosphate transferase complement(832084..832977) Wolbachia endosymbiont strain TRS of Brugia malayi 3266496 YP_198467.1 CDS Wbm0637 NC_006833.1 833053 833523 D hypothetical protein 833053..833523 Wolbachia endosymbiont strain TRS of Brugia malayi 3266501 YP_198468.1 CDS Wbm0638 NC_006833.1 833639 834265 D putative translation factor, SUA5 833639..834265 Wolbachia endosymbiont strain TRS of Brugia malayi 3266505 YP_198469.1 CDS Wbm0639 NC_006833.1 834243 835079 D DNA replication ATPase, HolB 834243..835079 Wolbachia endosymbiont strain TRS of Brugia malayi 3266506 YP_198470.1 CDS Wbm0640 NC_006833.1 835680 835934 D hypothetical protein 835680..835934 Wolbachia endosymbiont strain TRS of Brugia malayi 3266507 YP_198471.1 CDS Wbm0641 NC_006833.1 835982 836650 D Type IV secretory pathway, component VirB8 835982..836650 Wolbachia endosymbiont strain TRS of Brugia malayi 3266511 YP_198472.1 CDS rnhB NC_006833.1 836656 837267 R RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII complement(836656..837267) Wolbachia endosymbiont strain TRS of Brugia malayi 3266512 YP_198473.1 CDS mraY NC_006833.1 837274 838254 R First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase complement(837274..838254) Wolbachia endosymbiont strain TRS of Brugia malayi 3266513 YP_198474.1 CDS Wbm0644 NC_006833.1 838330 840453 R DNA segregation ATPase FtsK complement(838330..840453) Wolbachia endosymbiont strain TRS of Brugia malayi 3266517 YP_198475.1 CDS Wbm0645 NC_006833.1 840454 840732 R YggT family membrane protein complement(840454..840732) Wolbachia endosymbiont strain TRS of Brugia malayi 3266518 YP_198476.1 CDS Wbm0646 NC_006833.1 840948 841385 R hypothetical protein complement(840948..841385) Wolbachia endosymbiont strain TRS of Brugia malayi 3266519 YP_198477.1 CDS Wbm0647 NC_006833.1 842029 850548 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; fusion of rpoB and rpoC; beta and beta' subunits are part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta/beta' complement(842029..850548) Wolbachia endosymbiont strain TRS of Brugia malayi 3266376 YP_198478.1 CDS rplL NC_006833.1 850616 851017 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(850616..851017) Wolbachia endosymbiont strain TRS of Brugia malayi 3266377 YP_198479.1 CDS rplJ NC_006833.1 851043 851561 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(851043..851561) Wolbachia endosymbiont strain TRS of Brugia malayi 3266380 YP_198480.1 CDS rplA NC_006833.1 851573 852226 R in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 complement(851573..852226) Wolbachia endosymbiont strain TRS of Brugia malayi 3266382 YP_198481.1 CDS rplK NC_006833.1 852231 852671 R binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 complement(852231..852671) Wolbachia endosymbiont strain TRS of Brugia malayi 3266383 YP_198482.1 CDS Wbm0652 NC_006833.1 852674 853510 R transcription antiterminator complement(852674..853510) Wolbachia endosymbiont strain TRS of Brugia malayi 3266381 YP_198483.1 CDS Wbm0653 NC_006833.1 853808 854980 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(853808..854980) Wolbachia endosymbiont strain TRS of Brugia malayi 3266390 YP_198484.1 CDS Wbm0654 NC_006833.1 855331 856482 R catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit complement(855331..856482) Wolbachia endosymbiont strain TRS of Brugia malayi 3266393 YP_198485.1 CDS Wbm0655 NC_006833.1 856685 857191 D hypothetical protein 856685..857191 Wolbachia endosymbiont strain TRS of Brugia malayi 3266403 YP_198486.1 CDS Wbm0656 NC_006833.1 857276 858169 R methionyl-tRNA formyltransferase complement(857276..858169) Wolbachia endosymbiont strain TRS of Brugia malayi 3266416 YP_198487.1 CDS rplT NC_006833.1 858212 858577 R binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 complement(858212..858577) Wolbachia endosymbiont strain TRS of Brugia malayi 3266417 YP_198488.1 CDS rpmI NC_006833.1 858598 858795 R 50S ribosomal protein L35 complement(858598..858795) Wolbachia endosymbiont strain TRS of Brugia malayi 3266419 YP_198489.1 CDS Wbm0659 NC_006833.1 858918 859373 R hypothetical protein complement(858918..859373) Wolbachia endosymbiont strain TRS of Brugia malayi 3266443 YP_198490.1 CDS Wbm0660 NC_006833.1 859569 859904 R transcriptional regulator complement(859569..859904) Wolbachia endosymbiont strain TRS of Brugia malayi 3266444 YP_198491.1 CDS Wbm0661 NC_006833.1 859901 860209 R nucleoid DNA-binding protein complement(859901..860209) Wolbachia endosymbiont strain TRS of Brugia malayi 3266445 YP_198492.1 CDS Wbm0662 NC_006833.1 863466 863660 R hypothetical protein complement(863466..863660) Wolbachia endosymbiont strain TRS of Brugia malayi 3266269 YP_198493.1 CDS rpsD NC_006833.1 863784 864398 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(863784..864398) Wolbachia endosymbiont strain TRS of Brugia malayi 3266275 YP_198494.1 CDS Wbm0664 NC_006833.1 864536 866500 D transketolase 864536..866500 Wolbachia endosymbiont strain TRS of Brugia malayi 3266276 YP_198495.1 CDS Wbm0665 NC_006833.1 867240 867572 D hypothetical protein 867240..867572 Wolbachia endosymbiont strain TRS of Brugia malayi 3266277 YP_198496.1 CDS Wbm0666 NC_006833.1 868527 869525 D catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acyltransferase within the complex. The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2); it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase; pyruvate dehydrogenase subunit beta 868527..869525 Wolbachia endosymbiont strain TRS of Brugia malayi 3266280 YP_198497.1 CDS Wbm0667 NC_006833.1 870048 871844 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(870048..871844) Wolbachia endosymbiont strain TRS of Brugia malayi 3266286 YP_198498.1 CDS Wbm0668 NC_006833.1 871925 873295 R malonyl-CoA decarboxylase complement(871925..873295) Wolbachia endosymbiont strain TRS of Brugia malayi 3266287 YP_198499.1 CDS Wbm0669 NC_006833.1 876928 877245 R hypothetical protein complement(876928..877245) Wolbachia endosymbiont strain TRS of Brugia malayi 3266340 YP_198500.1 CDS Wbm0670 NC_006833.1 877313 878062 R hypothetical protein complement(877313..878062) Wolbachia endosymbiont strain TRS of Brugia malayi 3266341 YP_198501.1 CDS Wbm0671 NC_006833.1 878128 878841 R DNA uptake lipoprotein complement(878128..878841) Wolbachia endosymbiont strain TRS of Brugia malayi 3266346 YP_198502.1 CDS Wbm0672 NC_006833.1 879419 880402 R hypothetical protein complement(879419..880402) Wolbachia endosymbiont strain TRS of Brugia malayi 3266347 YP_198503.1 CDS Wbm0673 NC_006833.1 880511 881053 R phosphatidylglycerophosphate synthase complement(880511..881053) Wolbachia endosymbiont strain TRS of Brugia malayi 3266348 YP_198504.1 CDS Wbm0674 NC_006833.1 881171 882520 D malic enzyme 881171..882520 Wolbachia endosymbiont strain TRS of Brugia malayi 3266525 YP_198505.1 CDS Wbm0675 NC_006833.1 882599 882817 D stress-induced morphogen, BolA 882599..882817 Wolbachia endosymbiont strain TRS of Brugia malayi 3266365 YP_198506.1 CDS Wbm0676 NC_006833.1 882834 883154 D glutaredoxin-like protein 882834..883154 Wolbachia endosymbiont strain TRS of Brugia malayi 3266366 YP_198507.1 CDS Wbm0677 NC_006833.1 884576 885352 D ABC-type spermidine/putrescine transport system, ATPase component 884576..885352 Wolbachia endosymbiont strain TRS of Brugia malayi 3266730 YP_198508.1 CDS Wbm0678 NC_006833.1 885487 885654 D Sec-independent protein secretion pathway component, TatA 885487..885654 Wolbachia endosymbiont strain TRS of Brugia malayi 3266895 YP_198509.1 CDS Wbm0679 NC_006833.1 885803 886459 D ABC transporter permease 885803..886459 Wolbachia endosymbiont strain TRS of Brugia malayi 3266903 YP_198510.1 CDS cysS NC_006833.1 886523 887824 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 886523..887824 Wolbachia endosymbiont strain TRS of Brugia malayi 3266904 YP_198511.1 CDS Wbm0681 NC_006833.1 887831 888247 D hypothetical protein 887831..888247 Wolbachia endosymbiont strain TRS of Brugia malayi 3266905 YP_198512.1 CDS Wbm0682 NC_006833.1 888311 888625 R hypothetical protein complement(888311..888625) Wolbachia endosymbiont strain TRS of Brugia malayi 3266914 YP_198513.1 CDS Wbm0683 NC_006833.1 890024 890239 R hypothetical protein complement(890024..890239) Wolbachia endosymbiont strain TRS of Brugia malayi 3266957 YP_198514.1 CDS pgk NC_006833.1 890764 891963 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(890764..891963) Wolbachia endosymbiont strain TRS of Brugia malayi 3266961 YP_198515.1 CDS Wbm0685 NC_006833.1 892002 893021 R thioredoxin reductase complement(892002..893021) Wolbachia endosymbiont strain TRS of Brugia malayi 3266760 YP_198516.1 CDS Wbm0686 NC_006833.1 893933 894577 R similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity; putative translaldolase complement(893933..894577) Wolbachia endosymbiont strain TRS of Brugia malayi 3266761 YP_198517.1 CDS Wbm0687 NC_006833.1 894579 894839 R hypothetical protein complement(894579..894839) Wolbachia endosymbiont strain TRS of Brugia malayi 3266762 YP_198518.1 CDS Wbm0688 NC_006833.1 895333 895668 R F0F1-type ATP synthase, epsilon subunit complement(895333..895668) Wolbachia endosymbiont strain TRS of Brugia malayi 3266764 YP_198519.1 CDS Wbm0689 NC_006833.1 895674 897140 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(895674..897140) Wolbachia endosymbiont strain TRS of Brugia malayi 3266765 YP_198520.1 CDS Wbm0690 NC_006833.1 897224 898075 R ABC-type phosphate transport system, permease component complement(897224..898075) Wolbachia endosymbiont strain TRS of Brugia malayi 3266768 YP_198521.1 CDS rpmH NC_006833.1 898448 898582 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 898448..898582 Wolbachia endosymbiont strain TRS of Brugia malayi 3266697 YP_198522.1 CDS Wbm0692 NC_006833.1 898575 898934 D RNase P protein component 898575..898934 Wolbachia endosymbiont strain TRS of Brugia malayi 3266698 YP_198523.1 CDS Wbm0693 NC_006833.1 899021 899299 D hypothetical protein 899021..899299 Wolbachia endosymbiont strain TRS of Brugia malayi 3266386 YP_198524.1 CDS Wbm0694 NC_006833.1 902744 903757 D TPR repeat-containing methyltransferase 902744..903757 Wolbachia endosymbiont strain TRS of Brugia malayi 3266752 YP_198525.1 CDS Wbm0695 NC_006833.1 903812 905596 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 903812..905596 Wolbachia endosymbiont strain TRS of Brugia malayi 3267016 YP_198526.1 CDS Wbm0696 NC_006833.1 905597 906064 D endonuclease 905597..906064 Wolbachia endosymbiont strain TRS of Brugia malayi 3267017 YP_198527.1 CDS Wbm0697 NC_006833.1 906111 906599 R Holliday junction resolvasome, endonuclease subunit, RuvC complement(906111..906599) Wolbachia endosymbiont strain TRS of Brugia malayi 3266917 YP_198528.1 CDS Wbm0698 NC_006833.1 906600 907418 R cytochrome c oxidase, subunit 3 complement(906600..907418) Wolbachia endosymbiont strain TRS of Brugia malayi 3266508 YP_198529.1 CDS Wbm0699 NC_006833.1 908951 910123 R methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase complement(908951..910123) Wolbachia endosymbiont strain TRS of Brugia malayi 3266397 YP_198530.1 CDS rpmA NC_006833.1 910282 910539 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(910282..910539) Wolbachia endosymbiont strain TRS of Brugia malayi 3266939 YP_198531.1 CDS rplU NC_006833.1 910550 910852 R 50S ribosomal protein L21 complement(910550..910852) Wolbachia endosymbiont strain TRS of Brugia malayi 3266940 YP_198532.1 CDS Wbm0702 NC_006833.1 912546 912791 R hypothetical protein complement(912546..912791) Wolbachia endosymbiont strain TRS of Brugia malayi 3266676 YP_198533.1 CDS Wbm0703 NC_006833.1 913430 913651 R hypothetical protein complement(913430..913651) Wolbachia endosymbiont strain TRS of Brugia malayi 3266649 YP_198534.1 CDS gatB NC_006833.1 914478 915902 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(914478..915902) Wolbachia endosymbiont strain TRS of Brugia malayi 3266650 YP_198535.1 CDS Wbm0705 NC_006833.1 916600 917472 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 916600..917472 Wolbachia endosymbiont strain TRS of Brugia malayi 3266890 YP_198536.1 CDS Wbm0706 NC_006833.1 917490 918824 D hypothetical protein 917490..918824 Wolbachia endosymbiont strain TRS of Brugia malayi 3266979 YP_198537.1 CDS Wbm0707 NC_006833.1 919000 919254 D cold shock protein 919000..919254 Wolbachia endosymbiont strain TRS of Brugia malayi 3266980 YP_198538.1 CDS Wbm0708 NC_006833.1 919298 920524 D superfamily II DNA/RNA helicase 919298..920524 Wolbachia endosymbiont strain TRS of Brugia malayi 3267127 YP_198539.1 CDS Wbm0709 NC_006833.1 922687 923511 R catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase complement(922687..923511) Wolbachia endosymbiont strain TRS of Brugia malayi 3267040 YP_198540.1 CDS Wbm0710 NC_006833.1 923625 926105 D signal transduction histidine kinase and receiver 923625..926105 Wolbachia endosymbiont strain TRS of Brugia malayi 3266315 YP_198541.1 CDS Wbm0711 NC_006833.1 929613 930962 R DNA recombination protein rmuC-like protein complement(929613..930962) Wolbachia endosymbiont strain TRS of Brugia malayi 3266302 YP_198542.1 CDS Wbm0712 NC_006833.1 930994 931398 R hypothetical protein complement(930994..931398) Wolbachia endosymbiont strain TRS of Brugia malayi 3266303 YP_198543.1 CDS Wbm0713 NC_006833.1 934248 934529 D hypothetical protein 934248..934529 Wolbachia endosymbiont strain TRS of Brugia malayi 3267062 YP_198544.1 CDS Wbm0714 NC_006833.1 936355 937788 R protein kinase, AarF complement(936355..937788) Wolbachia endosymbiont strain TRS of Brugia malayi 3267009 YP_198545.1 CDS Wbm0715 NC_006833.1 937785 938525 R ABC-type Zn2+ transport systems, ATPase component complement(937785..938525) Wolbachia endosymbiont strain TRS of Brugia malayi 3266238 YP_198546.1 CDS Wbm0716 NC_006833.1 938664 939404 D ABC-type Zn2+ transport system, periplasmic component 938664..939404 Wolbachia endosymbiont strain TRS of Brugia malayi 3267049 YP_198547.1 CDS ndk NC_006833.1 939444 939863 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(939444..939863) Wolbachia endosymbiont strain TRS of Brugia malayi 3267050 YP_198548.1 CDS Wbm0718 NC_006833.1 939974 940726 D hypothetical protein 939974..940726 Wolbachia endosymbiont strain TRS of Brugia malayi 3266499 YP_198549.1 CDS hemH NC_006833.1 940727 941749 D protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 940727..941749 Wolbachia endosymbiont strain TRS of Brugia malayi 3266378 YP_198550.1 CDS Wbm0720 NC_006833.1 941827 942681 D hypothetical protein 941827..942681 Wolbachia endosymbiont strain TRS of Brugia malayi 3266379 YP_198551.1 CDS Wbm0721 NC_006833.1 942691 943851 R glutamate-cysteine ligase complement(942691..943851) Wolbachia endosymbiont strain TRS of Brugia malayi 3266434 YP_198552.1 CDS Wbm0722 NC_006833.1 943982 944512 D heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 943982..944512 Wolbachia endosymbiont strain TRS of Brugia malayi 3266292 YP_198553.1 CDS hslU NC_006833.1 944514 946004 D heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 944514..946004 Wolbachia endosymbiont strain TRS of Brugia malayi 3266293 YP_198554.1 CDS Wbm0724 NC_006833.1 947379 947669 R hypothetical protein complement(947379..947669) Wolbachia endosymbiont strain TRS of Brugia malayi 3266288 YP_198555.1 CDS Wbm0725 NC_006833.1 948160 950709 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 948160..950709 Wolbachia endosymbiont strain TRS of Brugia malayi 3267005 YP_198556.1 CDS Wbm0726 NC_006833.1 951311 952390 D hypothetical protein 951311..952390 Wolbachia endosymbiont strain TRS of Brugia malayi 3267006 YP_198557.1 CDS Wbm0727 NC_006833.1 952385 953812 R Zn-dependent protease TldD complement(952385..953812) Wolbachia endosymbiont strain TRS of Brugia malayi 3266569 YP_198558.1 CDS Wbm0728 NC_006833.1 956642 957349 D uroporphyrinogen-III synthase 956642..957349 Wolbachia endosymbiont strain TRS of Brugia malayi 3266515 YP_198559.1 CDS Wbm0729 NC_006833.1 957349 958131 D exonuclease III 957349..958131 Wolbachia endosymbiont strain TRS of Brugia malayi 3266400 YP_198560.1 CDS Wbm0730 NC_006833.1 958816 959817 D permease 958816..959817 Wolbachia endosymbiont strain TRS of Brugia malayi 3266401 YP_198561.1 CDS Wbm0731 NC_006833.1 959940 960575 D DNA replication initiation ATPase 959940..960575 Wolbachia endosymbiont strain TRS of Brugia malayi 3266435 YP_198562.1 CDS Wbm0732 NC_006833.1 960947 961933 D site-specific recombinase XerD 960947..961933 Wolbachia endosymbiont strain TRS of Brugia malayi 3266441 YP_198563.1 CDS Wbm0733 NC_006833.1 962136 962711 D 1-acyl-sn-glycerol-3-phosphate acyltransferase 962136..962711 Wolbachia endosymbiont strain TRS of Brugia malayi 3266442 YP_198564.1 CDS rpsT NC_006833.1 962775 963044 D binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 962775..963044 Wolbachia endosymbiont strain TRS of Brugia malayi 3266291 YP_198565.1 CDS Wbm0735 NC_006833.1 963110 964360 D citrate synthase 963110..964360 Wolbachia endosymbiont strain TRS of Brugia malayi 3266296 YP_198566.1 CDS Wbm0736 NC_006833.1 965180 966118 R FKBP-type peptidyl-prolyl cis-trans isomerase domain-containing protein complement(965180..966118) Wolbachia endosymbiont strain TRS of Brugia malayi 3266297 YP_198567.1 CDS Wbm0737 NC_006833.1 966111 967028 R geranylgeranyl pyrophosphate synthase complement(966111..967028) Wolbachia endosymbiont strain TRS of Brugia malayi 3266304 YP_198568.1 CDS Wbm0738 NC_006833.1 967179 967445 D Acyl carrier protein 967179..967445 Wolbachia endosymbiont strain TRS of Brugia malayi 3266312 YP_198569.1 CDS Wbm0739 NC_006833.1 967452 968720 D 3-oxoacyl-(acyl-carrier-protein) synthase 967452..968720 Wolbachia endosymbiont strain TRS of Brugia malayi 3266313 YP_198570.1 CDS Wbm0740 NC_006833.1 968818 970095 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 968818..970095 Wolbachia endosymbiont strain TRS of Brugia malayi 3266319 YP_198571.1 CDS thyX NC_006833.1 970105 970974 D flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase 970105..970974 Wolbachia endosymbiont strain TRS of Brugia malayi 3266326 YP_198572.1 CDS Wbm0742 NC_006833.1 971041 973131 R extracellular metallopeptidase complement(971041..973131) Wolbachia endosymbiont strain TRS of Brugia malayi 3266327 YP_198573.1 CDS Wbm0743 NC_006833.1 973934 974122 R hypothetical protein complement(973934..974122) Wolbachia endosymbiont strain TRS of Brugia malayi 3266350 YP_198574.1 CDS Wbm0744 NC_006833.1 974465 974749 D hypothetical protein 974465..974749 Wolbachia endosymbiont strain TRS of Brugia malayi 3266332 YP_198575.1 CDS Wbm0745 NC_006833.1 976010 978370 D primosomal protein N' 976010..978370 Wolbachia endosymbiont strain TRS of Brugia malayi 3266333 YP_198576.1 CDS recR NC_006833.1 978928 979533 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 978928..979533 Wolbachia endosymbiont strain TRS of Brugia malayi 3266360 YP_198577.1 CDS Wbm0747 NC_006833.1 981613 982884 R branched-chain alpha-keto acid dehydrogenase subunit E2 complement(981613..982884) Wolbachia endosymbiont strain TRS of Brugia malayi 3267080 YP_198578.1 CDS Wbm0748 NC_006833.1 983225 983653 R hypothetical protein complement(983225..983653) Wolbachia endosymbiont strain TRS of Brugia malayi 3267081 YP_198579.1 CDS Wbm0749 NC_006833.1 983877 986672 R hypothetical protein complement(983877..986672) Wolbachia endosymbiont strain TRS of Brugia malayi 3266529 YP_198580.1 CDS Wbm0750 NC_006833.1 986653 989007 R Type IV secretory pathway, VirB4 components complement(986653..989007) Wolbachia endosymbiont strain TRS of Brugia malayi 3266920 YP_198581.1 CDS Wbm0751 NC_006833.1 989038 989415 R hypothetical protein complement(989038..989415) Wolbachia endosymbiont strain TRS of Brugia malayi 3266921 YP_198582.1 CDS Wbm0752 NC_006833.1 989526 990761 R hypothetical protein complement(989526..990761) Wolbachia endosymbiont strain TRS of Brugia malayi 3266922 YP_198583.1 CDS Wbm0753 NC_006833.1 990873 991913 R trans-2-enoyl-ACP reductase, FabK complement(990873..991913) Wolbachia endosymbiont strain TRS of Brugia malayi 3266925 YP_198584.1 CDS Wbm0754 NC_006833.1 991919 992392 R cytochrome B561 complement(991919..992392) Wolbachia endosymbiont strain TRS of Brugia malayi 3266926 YP_198585.1 CDS Wbm0755 NC_006833.1 994435 995340 R Signal recognition particle GTPase complement(994435..995340) Wolbachia endosymbiont strain TRS of Brugia malayi 3266931 YP_198586.1 CDS Wbm0756 NC_006833.1 995525 995917 D scaffold protein 995525..995917 Wolbachia endosymbiont strain TRS of Brugia malayi 3266933 YP_198587.1 CDS Wbm0757 NC_006833.1 995924 996328 D HesB/YadR/YfhF family protein 995924..996328 Wolbachia endosymbiont strain TRS of Brugia malayi 3266934 YP_198588.1 CDS Wbm0758 NC_006833.1 996321 996776 D DnaJ-domain-containing protein 996321..996776 Wolbachia endosymbiont strain TRS of Brugia malayi 3266936 YP_198589.1 CDS Wbm0759 NC_006833.1 996754 998511 D molecular chaperone, DnaK 996754..998511 Wolbachia endosymbiont strain TRS of Brugia malayi 3266937 YP_198590.1 CDS Wbm0760 NC_006833.1 998514 999131 R Signal peptidase I complement(998514..999131) Wolbachia endosymbiont strain TRS of Brugia malayi 3266938 YP_198591.1 CDS Wbm0761 NC_006833.1 999169 999480 R hypothetical protein complement(999169..999480) Wolbachia endosymbiont strain TRS of Brugia malayi 3266963 YP_198592.1 CDS Wbm0762 NC_006833.1 999707 1000636 D permease 999707..1000636 Wolbachia endosymbiont strain TRS of Brugia malayi 3266964 YP_198593.1 CDS gatA NC_006833.1 1000701 1002137 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(1000701..1002137) Wolbachia endosymbiont strain TRS of Brugia malayi 3266965 YP_198594.1 CDS Wbm0764 NC_006833.1 1002821 1005199 R DNA gyrase, topoisomerase II, B subunit, GyrB complement(1002821..1005199) Wolbachia endosymbiont strain TRS of Brugia malayi 3266973 YP_198595.1 CDS Wbm0765 NC_006833.1 1006318 1006911 R hypothetical protein complement(1006318..1006911) Wolbachia endosymbiont strain TRS of Brugia malayi 3266976 YP_198596.1 CDS Wbm0766 NC_006833.1 1006999 1007334 R hypothetical protein complement(1006999..1007334) Wolbachia endosymbiont strain TRS of Brugia malayi 3266748 YP_198597.1 CDS Wbm0767 NC_006833.1 1007541 1009166 R hypothetical protein complement(1007541..1009166) Wolbachia endosymbiont strain TRS of Brugia malayi 3266750 YP_198598.1 CDS Wbm0768 NC_006833.1 1009621 1010658 D membrane protease subunit stomatin/prohibitin-like protein 1009621..1010658 Wolbachia endosymbiont strain TRS of Brugia malayi 3266751 YP_198599.1 CDS Wbm0769 NC_006833.1 1010661 1011533 D membrane protease subunit stomatin/prohibitin-like protein 1010661..1011533 Wolbachia endosymbiont strain TRS of Brugia malayi 3266774 YP_198600.1 CDS Wbm0770 NC_006833.1 1011537 1013027 D trypsin-like serine protease 1011537..1013027 Wolbachia endosymbiont strain TRS of Brugia malayi 3266772 YP_198601.1 CDS Wbm0771 NC_006833.1 1013958 1016159 R hypothetical protein complement(1013958..1016159) Wolbachia endosymbiont strain TRS of Brugia malayi 3266773 YP_198602.1 CDS Wbm0772 NC_006833.1 1016504 1017967 R hypothetical protein complement(1016504..1017967) Wolbachia endosymbiont strain TRS of Brugia malayi 3266782 YP_198603.1 CDS Wbm0773 NC_006833.1 1018068 1020005 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B complement(1018068..1020005) Wolbachia endosymbiont strain TRS of Brugia malayi 3267131 YP_198604.1 CDS Wbm0774 NC_006833.1 1020088 1020852 R cytochrome c1 complement(1020088..1020852) Wolbachia endosymbiont strain TRS of Brugia malayi 3267132 YP_198605.1 CDS Wbm0775 NC_006833.1 1020852 1022078 R cytochrome b subunit of the bc complex complement(1020852..1022078) Wolbachia endosymbiont strain TRS of Brugia malayi 3266887 YP_198606.1 CDS Wbm0776 NC_006833.1 1022508 1022975 D hypothetical protein 1022508..1022975 Wolbachia endosymbiont strain TRS of Brugia malayi 3266550 YP_198607.1 CDS hemC NC_006833.1 1026192 1027070 D transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 1026192..1027070 Wolbachia endosymbiont strain TRS of Brugia malayi 3266456 YP_198608.1 CDS murB NC_006833.1 1027061 1027948 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 1027061..1027948 Wolbachia endosymbiont strain TRS of Brugia malayi 3266282 YP_198609.1 CDS Wbm0779 NC_006833.1 1027974 1028240 R hypothetical protein complement(1027974..1028240) Wolbachia endosymbiont strain TRS of Brugia malayi 3266283 YP_198610.1 CDS Wbm0780 NC_006833.1 1028579 1028788 R hypothetical protein complement(1028579..1028788) Wolbachia endosymbiont strain TRS of Brugia malayi 3266741 YP_198611.1 CDS Wbm0781 NC_006833.1 1029578 1030141 D hypothetical protein 1029578..1030141 Wolbachia endosymbiont strain TRS of Brugia malayi 3266994 YP_198612.1 CDS ispG NC_006833.1 1030146 1031435 D catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 1030146..1031435 Wolbachia endosymbiont strain TRS of Brugia malayi 3266995 YP_198613.1 CDS Wbm0783 NC_006833.1 1034634 1034816 R hypothetical protein complement(1034634..1034816) Wolbachia endosymbiont strain TRS of Brugia malayi 3267133 YP_198614.1 CDS Wbm0784 NC_006833.1 1035157 1035339 R hypothetical protein complement(1035157..1035339) Wolbachia endosymbiont strain TRS of Brugia malayi 3266992 YP_198615.1 CDS Wbm0785 NC_006833.1 1035924 1037048 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 1035924..1037048 Wolbachia endosymbiont strain TRS of Brugia malayi 3266993 YP_198616.1 CDS valS NC_006833.1 1037757 1040324 D valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 1037757..1040324 Wolbachia endosymbiont strain TRS of Brugia malayi 3266972 YP_198617.1 CDS Wbm0787 NC_006833.1 1042188 1042865 D orotidine-5'-phosphate decarboxylase 1042188..1042865 Wolbachia endosymbiont strain TRS of Brugia malayi 3266717 YP_198618.1 CDS secD NC_006833.1 1044453 1045934 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 1044453..1045934 Wolbachia endosymbiont strain TRS of Brugia malayi 3266718 YP_198619.1 CDS Wbm0789 NC_006833.1 1046641 1047825 D Na+/H+-dicarboxylate symporter 1046641..1047825 Wolbachia endosymbiont strain TRS of Brugia malayi 3267059 YP_198620.1 CDS pyrE NC_006833.1 1047828 1048433 D involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 1047828..1048433 Wolbachia endosymbiont strain TRS of Brugia malayi 3266966 YP_198621.1 CDS Wbm0791 NC_006833.1 1050523 1051071 R N6-adenine-specific methylase complement(1050523..1051071) Wolbachia endosymbiont strain TRS of Brugia malayi 3266967 YP_198622.1 CDS Wbm0792 NC_006833.1 1051188 1051835 R hypothetical protein complement(1051188..1051835) Wolbachia endosymbiont strain TRS of Brugia malayi 3266897 YP_198623.1 CDS Wbm0793 NC_006833.1 1051828 1055067 R Type IV secretory pathway, VirB6 components complement(1051828..1055067) Wolbachia endosymbiont strain TRS of Brugia malayi 3266898 YP_198624.1 CDS Wbm0794 NC_006833.1 1055217 1058339 R Type IV secretory pathway, VirB6 components complement(1055217..1058339) Wolbachia endosymbiont strain TRS of Brugia malayi 3266930 YP_198625.1 CDS Wbm0795 NC_006833.1 1058336 1060738 R Type IV secretory pathway, VirB6 components complement(1058336..1060738) Wolbachia endosymbiont strain TRS of Brugia malayi 3266743 YP_198626.1 CDS Wbm0796 NC_006833.1 1060804 1063428 R Type IV secretory pathway, VirB6 components complement(1060804..1063428) Wolbachia endosymbiont strain TRS of Brugia malayi 3266744 YP_198627.1 CDS Wbm0797 NC_006833.1 1063421 1065826 R type IV secretion system ATPase VirB4 complement(1063421..1065826) Wolbachia endosymbiont strain TRS of Brugia malayi 3266737 YP_198628.1 CDS Wbm0798 NC_006833.1 1065836 1066132 R type IV secretion system protein VirB3 complement(1065836..1066132) Wolbachia endosymbiont strain TRS of Brugia malayi 3266738 YP_198629.1 CDS lysK NC_006833.1 1066331 1067770 D class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine; lysyl-tRNA synthetase 1066331..1067770 Wolbachia endosymbiont strain TRS of Brugia malayi 3266739 YP_198630.1 CDS Wbm0800 NC_006833.1 1068652 1069641 R glutamine amidotransferase domain-containing protein complement(1068652..1069641) Wolbachia endosymbiont strain TRS of Brugia malayi 3267064 YP_198631.1 CDS coaD NC_006833.1 1069887 1070390 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1069887..1070390 Wolbachia endosymbiont strain TRS of Brugia malayi 3267084 YP_198632.1 CDS Wbm0802 NC_006833.1 1070459 1070656 D NADH:ubiquinone oxidoreductase Fe-S subunit 1070459..1070656 Wolbachia endosymbiont strain TRS of Brugia malayi 3266716 YP_198633.1 CDS Wbm0803 NC_006833.1 1070680 1071306 R CDP-diglyceride synthetase complement(1070680..1071306) Wolbachia endosymbiont strain TRS of Brugia malayi 3266872 YP_198634.1 CDS Wbm0804 NC_006833.1 1071296 1071991 R undecaprenyl pyrophosphate synthase complement(1071296..1071991) Wolbachia endosymbiont strain TRS of Brugia malayi 3266873 YP_198635.1 CDS frr NC_006833.1 1072186 1072743 R Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor complement(1072186..1072743) Wolbachia endosymbiont strain TRS of Brugia malayi 3266687 YP_198636.1 CDS pyrH NC_006833.1 1072754 1073494 R Catalyzes the phosphorylation of UMP to UDP; uridylate kinase complement(1072754..1073494) Wolbachia endosymbiont strain TRS of Brugia malayi 3266246 YP_198637.2 CDS tsf NC_006833.1 1073505 1074374 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(1073505..1074374) Wolbachia endosymbiont strain TRS of Brugia malayi 3266247 YP_198638.2 CDS rpsB NC_006833.1 1074355 1075194 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(1074355..1075194) Wolbachia endosymbiont strain TRS of Brugia malayi 3266945 YP_198639.1 CDS Wbm0809 NC_006833.1 1078996 1079739 R hemolysin complement(1078996..1079739) Wolbachia endosymbiont strain TRS of Brugia malayi 3266712 Wbm7001 tRNA Wbm7001 NC_006833.1 15359 15444 D tRNA-Ser 15359..15444 Wolbachia endosymbiont strain TRS of Brugia malayi 3267126 Wbm7002 tRNA Wbm7002 NC_006833.1 43002 43089 D tRNA-Ser 43002..43089 Wolbachia endosymbiont strain TRS of Brugia malayi 3266395 Wbm7003 tRNA Wbm7003 NC_006833.1 81071 81143 R tRNA-Ala complement(81071..81143) Wolbachia endosymbiont strain TRS of Brugia malayi 3266622 Wbm7004 tRNA Wbm7004 NC_006833.1 121709 121780 D tRNA-Cys 121709..121780 Wolbachia endosymbiont strain TRS of Brugia malayi 3267067 Wbm7005 tRNA Wbm7005 NC_006833.1 162061 162133 D tRNA-His 162061..162133 Wolbachia endosymbiont strain TRS of Brugia malayi 3266254 Wbm7006 tRNA Wbm7006 NC_006833.1 283363 283436 R tRNA-Arg complement(283363..283436) Wolbachia endosymbiont strain TRS of Brugia malayi 3266477 Wbm7007 tRNA Wbm7007 NC_006833.1 306290 306363 D tRNA-Arg 306290..306363 Wolbachia endosymbiont strain TRS of Brugia malayi 3267055 Wbm7008 tRNA Wbm7008 NC_006833.1 364005 364089 D tRNA-Leu 364005..364089 Wolbachia endosymbiont strain TRS of Brugia malayi 3266982 Wbm7009 tRNA Wbm7009 NC_006833.1 396034 396116 D tRNA-Leu 396034..396116 Wolbachia endosymbiont strain TRS of Brugia malayi 3266791 Wbm7010 tRNA Wbm7010 NC_006833.1 491143 491215 R tRNA-Val complement(491143..491215) Wolbachia endosymbiont strain TRS of Brugia malayi 3266714 Wbm7011 tRNA Wbm7011 NC_006833.1 517358 517429 R tRNA-Asn complement(517358..517429) Wolbachia endosymbiont strain TRS of Brugia malayi 3267000 Wbm7012 tRNA Wbm7012 NC_006833.1 523698 523770 R tRNA-Val complement(523698..523770) Wolbachia endosymbiont strain TRS of Brugia malayi 3266781 Wbm7013 tRNA Wbm7013 NC_006833.1 528712 528784 D tRNA-Thr 528712..528784 Wolbachia endosymbiont strain TRS of Brugia malayi 3266438 Wbm7014 tRNA Wbm7014 NC_006833.1 619707 619779 R tRNA-Lys complement(619707..619779) Wolbachia endosymbiont strain TRS of Brugia malayi 3266754 Wbm7015 tRNA Wbm7015 NC_006833.1 656195 656267 D tRNA-Met 656195..656267 Wolbachia endosymbiont strain TRS of Brugia malayi 3266531 Wbm7016 tRNA Wbm7016 NC_006833.1 678622 678695 R tRNA-Pro complement(678622..678695) Wolbachia endosymbiont strain TRS of Brugia malayi 3266311 Wbm7017 tRNA Wbm7017 NC_006833.1 730696 730777 R tRNA-Leu complement(730696..730777) Wolbachia endosymbiont strain TRS of Brugia malayi 3266367 Wbm7018 tRNA Wbm7018 NC_006833.1 760371 760460 R tRNA-Ser complement(760371..760460) Wolbachia endosymbiont strain TRS of Brugia malayi 3266910 Wbm7019 tRNA Wbm7019 NC_006833.1 767034 767106 R tRNA-Thr complement(767034..767106) Wolbachia endosymbiont strain TRS of Brugia malayi 3266862 Wbm7020 tRNA Wbm7020 NC_006833.1 769450 769523 R tRNA-Met complement(769450..769523) Wolbachia endosymbiont strain TRS of Brugia malayi 3266709 Wbm7021 tRNA Wbm7021 NC_006833.1 798110 798183 R tRNA-Ile complement(798110..798183) Wolbachia endosymbiont strain TRS of Brugia malayi 3267018 Wbm7022 tRNA Wbm7022 NC_006833.1 799444 799516 D tRNA-Gly 799444..799516 Wolbachia endosymbiont strain TRS of Brugia malayi 3266398 Wbm7023 tRNA Wbm7023 NC_006833.1 853720 853792 R tRNA-Trp complement(853720..853792) Wolbachia endosymbiont strain TRS of Brugia malayi 3266389 Wbm7024 tRNA Wbm7024 NC_006833.1 855059 855130 R tRNA-Gly complement(855059..855130) Wolbachia endosymbiont strain TRS of Brugia malayi 3266391 Wbm7025 tRNA Wbm7025 NC_006833.1 855135 855216 R tRNA-Tyr complement(855135..855216) Wolbachia endosymbiont strain TRS of Brugia malayi 3266392 Wbm7026 tRNA Wbm7026 NC_006833.1 863691 863774 R tRNA-Leu complement(863691..863774) Wolbachia endosymbiont strain TRS of Brugia malayi 3266270 Wbm7027 tRNA Wbm7027 NC_006833.1 884350 884423 R tRNA-Arg complement(884350..884423) Wolbachia endosymbiont strain TRS of Brugia malayi 3266372 Wbm7028 tRNA Wbm7028 NC_006833.1 910187 910260 R tRNA-Ile complement(910187..910260) Wolbachia endosymbiont strain TRS of Brugia malayi 3266902 Wbm7029 tRNA Wbm7029 NC_006833.1 921230 921301 R tRNA-Glu complement(921230..921301) Wolbachia endosymbiont strain TRS of Brugia malayi 3266889 Wbm7030 tRNA Wbm7030 NC_006833.1 929501 929575 D tRNA-Arg 929501..929575 Wolbachia endosymbiont strain TRS of Brugia malayi 3266780 Wbm7031 tRNA Wbm7031 NC_006833.1 953875 953959 D tRNA-Leu 953875..953959 Wolbachia endosymbiont strain TRS of Brugia malayi 3266264 Wbm7032 tRNA Wbm7032 NC_006833.1 1006937 1007008 R tRNA-Gln complement(1006937..1007008) Wolbachia endosymbiont strain TRS of Brugia malayi 3266977 Wbm7033 tRNA Wbm7033 NC_006833.1 1069733 1069805 R tRNA-Phe complement(1069733..1069805) Wolbachia endosymbiont strain TRS of Brugia malayi 3267083 Wbm7034 tRNA Wbm7034 NC_006833.1 1075386 1075459 D tRNA-Asp 1075386..1075459 Wolbachia endosymbiont strain TRS of Brugia malayi 3266711 Wbm9003 rRNA Wbm9003 NC_006833.1 634569 636083 R 16S ribosomal RNA complement(634569..636083) Wolbachia endosymbiont strain TRS of Brugia malayi 3266528 Wbm9002 rRNA Wbm9002 NC_006833.1 899374 899498 R 5S ribosomal RNA complement(899374..899498) Wolbachia endosymbiont strain TRS of Brugia malayi 3266411 Wbm9001 rRNA Wbm9001 NC_006833.1 899547 902342 R 23S ribosomal RNA complement(899547..902342) Wolbachia endosymbiont strain TRS of Brugia malayi 3266412