-- dump date 20111121_015623 -- class Genbank::misc_feature -- table misc_feature_note -- id note 570417000001 the first base of this sequence corresponds to the original of replication 570417000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 570417000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 570417000004 Walker A motif; other site 570417000005 ATP binding site [chemical binding]; other site 570417000006 Walker B motif; other site 570417000007 arginine finger; other site 570417000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 570417000009 DnaA box-binding interface [nucleotide binding]; other site 570417000012 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000014 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 570417000015 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 570417000016 Protein export membrane protein; Region: SecD_SecF; cl14618 570417000017 6 probable transmembrane helices predicted for WP0002 by TMHMM2.0 at aa 20-42, 127-149, 156-178, 182-204, 229-251 and 261-283 570417000022 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 570417000023 catalytic motif [active] 570417000024 Catalytic residue [active] 570417000027 PS00141 Eukaryotic and viral aspartyl proteases active site. 570417000028 1 probable transmembrane helix predicted for WP0003 by TMHMM2.0 at aa 7-24 570417000029 membrane protein insertase; Provisional; Region: PRK01318 570417000030 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 570417000031 5 probable transmembrane helices predicted for WP0004 by TMHMM2.0 at aa 7-25, 352-374, 424-446, 468-490 and 518-540 570417000033 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 570417000034 homopentamer interface [polypeptide binding]; other site 570417000035 active site 570417000037 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 570417000038 putative RNA binding site [nucleotide binding]; other site 570417000041 2 probable transmembrane helices predicted for WP0007 by TMHMM2.0 at aa 17-39 and 54-76 570417000042 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 570417000043 trimer interface [polypeptide binding]; other site 570417000044 active site 570417000045 dUTPase; Provisional; Region: PHA03126 570417000048 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 570417000049 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 570417000050 oligomerization interface [polypeptide binding]; other site 570417000051 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 570417000054 prolyl-tRNA synthetase; Provisional; Region: PRK12325 570417000055 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 570417000056 dimer interface [polypeptide binding]; other site 570417000057 motif 1; other site 570417000058 active site 570417000059 motif 2; other site 570417000060 motif 3; other site 570417000061 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 570417000062 anticodon binding site; other site 570417000066 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 570417000067 2 probable transmembrane helices predicted for WP0017 by TMHMM2.0 at aa 168-190 and 200-222 570417000068 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 570417000069 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000070 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 570417000071 dimer interface [polypeptide binding]; other site 570417000072 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 570417000073 putative radical transfer pathway; other site 570417000074 diiron center [ion binding]; other site 570417000075 tyrosyl radical; other site 570417000077 1 probable transmembrane helix predicted for WP0020 by TMHMM2.0 at aa 153-175 570417000078 transposase (fragment);Might be merged with tmp1115 570417000079 transposase (fragment);Might be merged with tmp1114 570417000080 2 probable transmembrane helices predicted for WP0024 by TMHMM2.0 at aa 222-244 and 248-270 570417000081 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 570417000082 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 570417000083 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 570417000085 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000086 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 570417000087 oligomerisation interface [polypeptide binding]; other site 570417000088 mobile loop; other site 570417000089 roof hairpin; other site 570417000091 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 570417000092 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 570417000093 ring oligomerisation interface [polypeptide binding]; other site 570417000094 ATP/Mg binding site [chemical binding]; other site 570417000095 stacking interactions; other site 570417000096 hinge regions; other site 570417000099 PS00296 Chaperonins cpn60 signature. 570417000100 Transposase; Region: HTH_Tnp_IS630; pfam01710 570417000101 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000102 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000103 Integrase core domain; Region: rve; cl01316 570417000104 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 570417000105 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000106 2 probable transmembrane helices predicted for WP0032 by TMHMM2.0 at aa 5-27 and 42-64 570417000107 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 570417000108 11 probable transmembrane helices predicted for WP0033 by TMHMM2.0 at aa 6-25, 53-75, 85-107, 135-154, 164-186, 193-215, 242-264, 294-316, 342-364, 385-403 and 408-425 570417000110 Putative transposase (pseudogene) 570417000111 PS00037 Myb DNA-binding domain repeat signature 1. 570417000112 Maf-like protein; Region: Maf; pfam02545 570417000113 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 570417000114 active site 570417000115 dimer interface [polypeptide binding]; other site 570417000118 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 570417000119 rRNA binding site [nucleotide binding]; other site 570417000120 predicted 30S ribosome binding site; other site 570417000123 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 570417000124 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 570417000125 GDP-binding site [chemical binding]; other site 570417000126 ACT binding site; other site 570417000127 IMP binding site; other site 570417000130 PS00513 Adenylosuccinate synthetase active site. 570417000131 PS01266 Adenylosuccinate synthetase GTP-binding site. 570417000132 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 570417000133 feedback inhibition sensing region; other site 570417000134 homohexameric interface [polypeptide binding]; other site 570417000135 nucleotide binding site [chemical binding]; other site 570417000136 N-acetyl-L-glutamate binding site [chemical binding]; other site 570417000139 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 570417000140 G1 box; other site 570417000141 GTP/Mg2+ binding site [chemical binding]; other site 570417000142 Switch I region; other site 570417000143 G2 box; other site 570417000144 G3 box; other site 570417000145 Switch II region; other site 570417000146 G4 box; other site 570417000147 G5 box; other site 570417000150 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000151 peptide chain release factor 1; Validated; Region: prfA; PRK00591 570417000152 RF-1 domain; Region: RF-1; cl02875 570417000153 RF-1 domain; Region: RF-1; cl02875 570417000157 PS00745 Prokaryotic-type class I peptide chain release factors signature. 570417000158 Membrane transport protein; Region: Mem_trans; cl09117 570417000159 10 probable transmembrane helices predicted for WP0045 by TMHMM2.0 at aa 4-23, 36-53, 63-85, 92-114, 119-141, 153-175, 185-204, 216-238, 253-275 and 282-304 570417000161 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 570417000163 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 570417000164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 570417000165 putative substrate translocation pore; other site 570417000167 11 probable transmembrane helices predicted for WP0047 by TMHMM2.0 at aa 37-59, 71-93, 97-114, 126-148, 158-177, 198-220, 240-262, 269-291, 301-323, 336-355 and 360-382 570417000168 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000169 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417000171 UDP-N-acetylmuramate--l-alanine ligase (fragment) 570417000174 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 570417000175 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 570417000176 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000179 transposase (pseudogene) 570417000181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417000182 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 570417000185 PS01304 ubiH/COQ6 monooxygenase family signature. 570417000186 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417000188 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 570417000189 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 570417000190 1 probable transmembrane helix predicted for WP0056 by TMHMM2.0 at aa 7-24 570417000191 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 570417000192 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 570417000193 active site 570417000194 (T/H)XGH motif; other site 570417000198 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 570417000200 PS01315 Phosphatidate cytidylyltransferase signature. 570417000201 6 probable transmembrane helices predicted for WP0059 by TMHMM2.0 at aa 7-26, 30-49, 56-78, 82-101, 120-142 and 146-163 570417000202 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 570417000203 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 570417000204 catalytic residue [active] 570417000205 putative FPP diphosphate binding site; other site 570417000206 putative FPP binding hydrophobic cleft; other site 570417000207 dimer interface [polypeptide binding]; other site 570417000208 putative IPP diphosphate binding site; other site 570417000211 PS01066 Undecaprenyl pyrophosphate synthetase family signature. 570417000212 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 570417000213 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 570417000214 E3 interaction surface; other site 570417000215 lipoyl attachment site [posttranslational modification]; other site 570417000216 e3 binding domain; Region: E3_binding; pfam02817 570417000217 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 570417000220 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 570417000223 Putative transposase (pseudogene) 570417000225 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 570417000226 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 570417000227 NAD binding site [chemical binding]; other site 570417000228 homotetramer interface [polypeptide binding]; other site 570417000229 homodimer interface [polypeptide binding]; other site 570417000230 substrate binding site [chemical binding]; other site 570417000231 active site 570417000232 transposase (pseudogene);contains in frame stop codon 570417000234 GTP-binding protein YchF; Reviewed; Region: PRK09601 570417000235 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 570417000236 G1 box; other site 570417000237 GTP/Mg2+ binding site [chemical binding]; other site 570417000238 Switch I region; other site 570417000239 G2 box; other site 570417000240 Switch II region; other site 570417000241 G3 box; other site 570417000242 G4 box; other site 570417000243 G5 box; other site 570417000244 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 570417000246 PS00443 Glutamine amidotransferases class-II active site. 570417000248 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000250 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 570417000251 putative active site [active] 570417000254 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417000255 2 probable transmembrane helices predicted for WP0072 by TMHMM2.0 at aa 373-395 and 399-421 570417000256 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 570417000257 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 570417000258 Walker A/P-loop; other site 570417000259 ATP binding site [chemical binding]; other site 570417000260 Q-loop/lid; other site 570417000261 ABC transporter signature motif; other site 570417000262 Walker B; other site 570417000263 D-loop; other site 570417000264 H-loop/switch region; other site 570417000266 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000267 PS00146 Beta-lactamase class-A active site. 570417000268 PS00211 ABC transporters family signature. 570417000269 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 570417000272 1 probable transmembrane helix predicted for WP0074 by TMHMM2.0 at aa 5-27 570417000273 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 570417000275 4 probable transmembrane helices predicted for WP0075 by TMHMM2.0 at aa 45-63, 67-86, 129-151 and 177-199 570417000276 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 570417000278 3 probable transmembrane helices predicted for WP0076 by TMHMM2.0 at aa 45-67, 138-160 and 177-199 570417000279 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 570417000280 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 570417000281 active site 570417000282 HIGH motif; other site 570417000283 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 570417000284 KMSKS motif; other site 570417000285 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 570417000286 tRNA binding surface [nucleotide binding]; other site 570417000287 anticodon binding site; other site 570417000290 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 570417000291 4 probable transmembrane helices predicted for WP0078 by TMHMM2.0 at aa 7-29, 39-61, 82-104 and 114-136 570417000292 1 probable transmembrane helix predicted for WP0079 by TMHMM2.0 at aa 5-23 570417000293 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000294 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 570417000295 RNA/DNA hybrid binding site [nucleotide binding]; other site 570417000296 active site 570417000298 UbiA prenyltransferase family; Region: UbiA; cl00337 570417000299 9 probable transmembrane helices predicted for WP0081 by TMHMM2.0 at aa 24-43, 47-69, 90-112, 116-137, 144-163, 167-189, 218-235, 239-261 and 273-292 570417000302 PS00943 UbiA prenyltransferase family signature. 570417000303 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 570417000304 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 570417000305 Subunit I/III interface [polypeptide binding]; other site 570417000306 D-pathway; other site 570417000307 Subunit I/VIIc interface [polypeptide binding]; other site 570417000308 Subunit I/IV interface [polypeptide binding]; other site 570417000309 Subunit I/II interface [polypeptide binding]; other site 570417000310 Low-spin heme (heme a) binding site [chemical binding]; other site 570417000311 Subunit I/VIIa interface [polypeptide binding]; other site 570417000312 Subunit I/VIa interface [polypeptide binding]; other site 570417000313 Dimer interface; other site 570417000314 Putative water exit pathway; other site 570417000315 Binuclear center (heme a3/CuB) [ion binding]; other site 570417000316 K-pathway; other site 570417000317 Subunit I/Vb interface [polypeptide binding]; other site 570417000318 Putative proton exit pathway; other site 570417000319 Subunit I/VIb interface; other site 570417000320 Subunit I/VIc interface [polypeptide binding]; other site 570417000321 Electron transfer pathway; other site 570417000322 Subunit I/VIIIb interface [polypeptide binding]; other site 570417000323 Subunit I/VIIb interface [polypeptide binding]; other site 570417000324 12 probable transmembrane helices predicted for WP0082 by TMHMM2.0 at aa 20-42, 62-84, 105-124, 152-174, 187-209, 241-263, 270-292, 307-329, 342-364, 379-401, 413-435 and 455-477 570417000326 PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 570417000327 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 570417000328 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 570417000329 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 570417000331 PS00078 CO II and nitrous oxide reductase dinuclear copper centers signature. 570417000333 3 probable transmembrane helices predicted for WP0083 by TMHMM2.0 at aa 7-29, 44-66 and 79-101 570417000334 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 570417000337 1 probable transmembrane helix predicted for WP0084 by TMHMM2.0 at aa 69-91 570417000338 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 570417000341 4 probable transmembrane helices predicted for WP0085 by TMHMM2.0 at aa 10-31, 52-74, 84-101 and 117-139 570417000342 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 570417000343 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 570417000344 tetramer interface [polypeptide binding]; other site 570417000345 TPP-binding site [chemical binding]; other site 570417000346 heterodimer interface [polypeptide binding]; other site 570417000347 phosphorylation loop region [posttranslational modification] 570417000349 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 570417000350 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 570417000351 GatB domain; Region: GatB_Yqey; cl11497 570417000356 ankyrin repeat domain protein;wPip_ANK1 570417000357 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000366 transposase (pseudogene);Disrupted by IS insertion 570417000367 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417000369 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 570417000370 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 570417000371 DNA binding site [nucleotide binding] 570417000372 Int/Topo IB signature motif; other site 570417000373 active site 570417000376 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 570417000377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417000378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417000379 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 570417000382 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000387 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 570417000388 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 570417000389 active site 570417000390 Trp docking motif [polypeptide binding]; other site 570417000391 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 570417000393 12 probable transmembrane helices predicted for WP0095 by TMHMM2.0 at aa 13-35, 55-77, 84-106, 126-145, 152-174, 194-216, 228-250, 260-282, 294-313, 323-342, 359-381 and 401-423 570417000394 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000395 3 probable transmembrane helices predicted for WP0096 by TMHMM2.0 at aa 4-26, 123-142 and 152-169 570417000396 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 570417000397 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 570417000398 active site 570417000399 HIGH motif; other site 570417000400 nucleotide binding site [chemical binding]; other site 570417000401 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 570417000402 active site 570417000403 KMSKS motif; other site 570417000404 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 570417000405 tRNA binding surface [nucleotide binding]; other site 570417000406 anticodon binding site; other site 570417000409 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 570417000411 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 570417000412 transposase (pseudogene) 570417000414 phosphodiesterase; Provisional; Region: PRK12704 570417000415 2 probable transmembrane helices predicted for WP0100 by TMHMM2.0 at aa 10-32 and 34-56 570417000416 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 570417000417 active site 570417000418 dimer interface [polypeptide binding]; other site 570417000421 PS00156 Orotidine 5'-phosphate decarboxylase active site. 570417000423 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 570417000424 Phage capsid family; Region: Phage_capsid; pfam05065 570417000425 PS00584 pfkB family of carbohydrate kinases signature 2. 570417000427 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417000429 dihydrodipicolinate reductase; Provisional; Region: PRK00048 570417000430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417000431 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 570417000435 PS01298 Dihydrodipicolinate reductase signature. 570417000436 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14244 570417000437 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 570417000438 Walker A/P-loop; other site 570417000439 ATP binding site [chemical binding]; other site 570417000440 Q-loop/lid; other site 570417000441 ABC transporter signature motif; other site 570417000442 Walker B; other site 570417000443 D-loop; other site 570417000444 H-loop/switch region; other site 570417000447 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000448 PS00211 ABC transporters family signature. 570417000449 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417000451 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 570417000453 2 probable transmembrane helices predicted for WP0112 by TMHMM2.0 at aa 151-169 and 173-191 570417000454 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000455 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 570417000456 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 570417000457 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 570417000461 WH2 motif containing protein (fragment);Disrupted by IS insertion. No stop codon 570417000463 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417000465 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 570417000466 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 570417000467 active site 570417000468 HIGH motif; other site 570417000469 KMSKS motif; other site 570417000470 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 570417000471 tRNA binding surface [nucleotide binding]; other site 570417000472 anticodon binding site; other site 570417000474 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 570417000475 3 probable transmembrane helices predicted for WP0119 by TMHMM2.0 at aa 133-155, 180-202 and 204-226 570417000476 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000477 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000478 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 570417000479 FMN binding site [chemical binding]; other site 570417000480 substrate binding site [chemical binding]; other site 570417000481 putative catalytic residue [active] 570417000483 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 570417000484 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 570417000485 CoA-binding site [chemical binding]; other site 570417000486 ATP-binding [chemical binding]; other site 570417000489 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000490 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 570417000491 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 570417000492 putative active site [active] 570417000493 catalytic site [active] 570417000494 putative substrate binding site [chemical binding]; other site 570417000496 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 570417000497 dihydroorotase; Validated; Region: pyrC; PRK09357 570417000498 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 570417000499 active site 570417000502 PS00483 Dihydroorotase signature 2. 570417000503 PS00482 Dihydroorotase signature 1. 570417000504 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000505 transposase (pseudogene) 570417000507 putative lipase (fragment);Disrupted by IS insertion. No stop codon 570417000509 PS00120 Lipases, serine active site. 570417000510 RDD family; Region: RDD; cl00746 570417000512 3 probable transmembrane helices predicted for WP0127 by TMHMM2.0 at aa 41-63, 99-121 and 153-172 570417000513 replicative DNA helicase; Provisional; Region: PRK09165 570417000514 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 570417000515 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 570417000516 Walker A motif; other site 570417000517 ATP binding site [chemical binding]; other site 570417000518 Walker B motif; other site 570417000519 DNA binding loops [nucleotide binding] 570417000523 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000524 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK06589 570417000525 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 570417000526 14 probable transmembrane helices predicted for WP0129 by TMHMM2.0 at aa 10-32, 45-67, 91-113, 125-142, 146-165, 178-200, 215-237, 258-280, 295-317, 324-346, 350-372, 393-415, 430-452 and 472-494 570417000527 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000529 VirB8 protein; Region: VirB8; cl01500 570417000530 1 probable transmembrane helix predicted for WP0130 by TMHMM2.0 at aa 33-55 570417000531 DNA polymerase III subunit delta'; Validated; Region: PRK09112 570417000532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 570417000533 Walker A motif; other site 570417000534 ATP binding site [chemical binding]; other site 570417000535 Walker B motif; other site 570417000536 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 570417000539 IPP transferase; Region: IPPT; cl00403 570417000540 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 570417000542 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000544 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417000546 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 570417000547 Wolbachia palindromic element (WPE) domain; Region: WPE_wolbac; TIGR02697 570417000548 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 570417000549 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 570417000553 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 570417000554 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 570417000555 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 570417000556 catalytic residue [active] 570417000559 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000560 BolA-like protein; Region: BolA; cl00386 570417000562 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 570417000565 PS01036 Heat shock hsp70 proteins family signature 3. 570417000566 PS00329 Heat shock hsp70 proteins family signature 2. 570417000567 PS00297 Heat shock hsp70 proteins family signature 1. 570417000568 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 570417000569 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 570417000570 homodimer interface [polypeptide binding]; other site 570417000571 oligonucleotide binding site [chemical binding]; other site 570417000574 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 570417000575 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 570417000578 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 570417000579 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 570417000580 metal binding site [ion binding]; metal-binding site 570417000582 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 570417000583 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 570417000585 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000586 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 570417000589 1 probable transmembrane helix predicted for WP0147 by TMHMM2.0 at aa 455-472 570417000590 ankyrin repeat domain protein;wPip_ANK3; Disrupted by IS insertion. 570417000591 transposase (pseudogene) 570417000596 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 570417000597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417000601 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 570417000602 1 probable transmembrane helix predicted for WP0150 by TMHMM2.0 at aa 7-29 570417000603 peroxidase; Provisional; Region: PRK15000 570417000604 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 570417000605 dimer interface [polypeptide binding]; other site 570417000606 decamer (pentamer of dimers) interface [polypeptide binding]; other site 570417000607 catalytic triad [active] 570417000608 peroxidatic and resolving cysteines [active] 570417000611 2 probable transmembrane helices predicted for WP0154 by TMHMM2.0 at aa 311-333 and 337-359 570417000612 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 570417000613 6 probable transmembrane helices predicted for WP0155 by TMHMM2.0 at aa 21-39, 78-100, 112-134, 171-193, 205-223 and 227-246 570417000616 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000617 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 570417000618 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 570417000619 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 570417000623 2 probable transmembrane helices predicted for WP0157 by TMHMM2.0 at aa 26-48 and 55-77 570417000624 Integrase core domain; Region: rve; cl01316 570417000625 Transposase; Region: HTH_Tnp_IS630; pfam01710 570417000626 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000627 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000628 4 probable transmembrane helices predicted for WP0160 by TMHMM2.0 at aa 130-152, 162-184, 210-228 and 238-260 570417000629 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 570417000632 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 570417000633 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 570417000634 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 570417000635 active site 570417000636 NTP binding site [chemical binding]; other site 570417000637 metal binding triad [ion binding]; metal-binding site 570417000638 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 570417000640 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 570417000641 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 570417000642 G1 box; other site 570417000643 putative GEF interaction site [polypeptide binding]; other site 570417000644 GTP/Mg2+ binding site [chemical binding]; other site 570417000645 Switch I region; other site 570417000646 G2 box; other site 570417000647 G3 box; other site 570417000648 Switch II region; other site 570417000649 G4 box; other site 570417000650 G5 box; other site 570417000651 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 570417000652 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 570417000658 PS00301 GTP-binding elongation factors signature. 570417000659 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000660 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 570417000661 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 570417000662 active site 570417000663 HIGH motif; other site 570417000664 nucleotide binding site [chemical binding]; other site 570417000665 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 570417000666 active site 570417000667 KMSKS motif; other site 570417000670 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 570417000671 Putative transposase (fragment);Cannot be merged with tmp1269 even though both are fragment, the merged protein does not give a hit with the full length 570417000672 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 570417000673 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 570417000674 putative active site [active] 570417000675 putative NTP binding site [chemical binding]; other site 570417000676 putative nucleic acid binding site [nucleotide binding]; other site 570417000677 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 570417000679 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 570417000681 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 570417000682 7 probable transmembrane helices predicted for WP0172 by TMHMM2.0 at aa 12-34, 54-76, 89-111, 131-153, 176-198, 213-235 and 242-264 570417000684 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 570417000686 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14610 570417000687 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 570417000690 PS00430 TonB-dependent receptor proteins signature 1. 570417000691 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 570417000692 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417000693 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417000694 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 570417000696 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000697 Cytochrome C biogenesis protein; Region: CcmH; cl01179 570417000699 2 probable transmembrane helices predicted for WP0176 by TMHMM2.0 at aa 5-22 and 103-120 570417000700 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000701 PS00362 Ribosomal protein S15 signature. 570417000702 1 probable transmembrane helix predicted for WP0177 by TMHMM2.0 at aa 5-27 570417000703 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 570417000704 catalytic loop [active] 570417000705 iron binding site [ion binding]; other site 570417000707 PS00814 Adrenodoxin family, iron-sulfur binding region signature. 570417000708 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417000709 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417000710 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417000711 2 probable transmembrane helices predicted for WP0179 by TMHMM2.0 at aa 269-291 and 295-317 570417000712 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000713 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417000715 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 570417000716 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 570417000718 12 probable transmembrane helices predicted for WP0181 by TMHMM2.0 at aa 2-24, 28-50, 71-93, 119-141, 153-175, 190-212, 219-241, 245-264, 285-303, 323-345, 365-387 and 397-419 570417000719 DNA primase; Validated; Region: dnaG; PRK05667 570417000720 CHC2 zinc finger; Region: zf-CHC2; cl15369 570417000721 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 570417000722 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 570417000723 active site 570417000724 metal binding site [ion binding]; metal-binding site 570417000725 interdomain interaction site; other site 570417000730 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 570417000731 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 570417000732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 570417000733 S-adenosylmethionine binding site [chemical binding]; other site 570417000742 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 570417000743 10 probable transmembrane helices predicted for WP0184 by TMHMM2.0 at aa 2-21, 31-53, 66-88, 119-141, 154-176, 191-213, 220-239, 272-294, 301-323 and 338-360 570417000744 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 570417000746 Predicted nucleotide kinase (related to CMP and AMP kinases) [Nucleotide transport and metabolism]; Region: COG1936 570417000747 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 570417000748 intersubunit interface [polypeptide binding]; other site 570417000749 active site 570417000750 Zn2+ binding site [ion binding]; other site 570417000752 putative transposase (pseudogene) 570417000753 Putative transposase (pseudogene) 570417000754 CcmB protein; Region: CcmB; cl01016 570417000756 6 probable transmembrane helices predicted for WP0190 by TMHMM2.0 at aa 15-34, 41-58, 89-111, 124-146, 151-173 and 180-202 570417000757 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 570417000758 transposase (pseudogene) 570417000761 transposase (fragment) 570417000762 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 570417000763 HSP70 interaction site [polypeptide binding]; other site 570417000764 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417000765 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417000766 2 probable transmembrane helices predicted for WP0195 by TMHMM2.0 at aa 332-354 and 361-383 570417000767 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 570417000768 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 570417000771 1 probable transmembrane helix predicted for WP0198 by TMHMM2.0 at aa 120-142 570417000772 DNA translocase FtsK; Provisional; Region: PRK10263 570417000773 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417000774 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 570417000776 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000777 PS00044 Bacterial regulatory proteins, lysR family signature. 570417000778 5 probable transmembrane helices predicted for WP0199 by TMHMM2.0 at aa 9-27, 54-76, 83-102, 117-139 and 146-165 570417000779 YGGT family; Region: YGGT; cl00508 570417000780 2 probable transmembrane helices predicted for WP0200 by TMHMM2.0 at aa 7-29 and 69-91 570417000782 Putative transposase (pseudogene) 570417000783 Stringent starvation protein B; Region: SspB; cl01120 570417000785 GTPase CgtA; Reviewed; Region: obgE; PRK12299 570417000786 GTP1/OBG; Region: GTP1_OBG; pfam01018 570417000787 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 570417000788 G1 box; other site 570417000789 GTP/Mg2+ binding site [chemical binding]; other site 570417000790 Switch I region; other site 570417000791 G2 box; other site 570417000792 G3 box; other site 570417000793 Switch II region; other site 570417000794 G4 box; other site 570417000795 G5 box; other site 570417000797 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000799 enolase; Provisional; Region: eno; PRK00077 570417000800 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 570417000801 dimer interface [polypeptide binding]; other site 570417000802 metal binding site [ion binding]; metal-binding site 570417000803 substrate binding pocket [chemical binding]; other site 570417000806 PS00164 Enolase signature. 570417000808 Wolbachia palindromic element (WPE) domain; Region: WPE_wolbac; TIGR02697 570417000809 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 570417000810 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 570417000812 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 570417000813 2 probable transmembrane helices predicted for WP0208 by TMHMM2.0 at aa 7-29 and 177-196 570417000814 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 570417000815 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 570417000816 dinuclear metal binding motif [ion binding]; other site 570417000819 RDD family; Region: RDD; cl00746 570417000820 3 probable transmembrane helices predicted for WP0210 by TMHMM2.0 at aa 11-33, 37-59 and 112-134 570417000821 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 570417000822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 570417000823 active site 570417000824 motif I; other site 570417000825 motif II; other site 570417000828 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 570417000829 Putative transposase (pseudogene) 570417000830 Hypothetical protein (pseudogene);Disrupted by IS insertion 570417000831 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417000833 fumarate hydratase; Reviewed; Region: fumC; PRK00485 570417000834 Class II fumarases; Region: Fumarase_classII; cd01362 570417000835 active site 570417000836 tetramer interface [polypeptide binding]; other site 570417000839 PS00163 Fumarate lyases signature. 570417000840 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417000841 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417000842 2 probable transmembrane helices predicted for WP0217 by TMHMM2.0 at aa 173-190 and 195-217 570417000843 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000847 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417000848 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417000852 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 570417000853 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 570417000854 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 570417000855 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 570417000856 dimerization interface [polypeptide binding]; other site 570417000857 ATP binding site [chemical binding]; other site 570417000858 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 570417000859 dimerization interface [polypeptide binding]; other site 570417000860 ATP binding site [chemical binding]; other site 570417000864 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 570417000865 4 probable transmembrane helices predicted for WP0221 by TMHMM2.0 at aa 21-43, 66-88, 100-122 and 137-159 570417000866 chaperone protein DnaJ; Provisional; Region: PRK10767 570417000867 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 570417000868 HSP70 interaction site [polypeptide binding]; other site 570417000869 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 570417000870 Zn binding sites [ion binding]; other site 570417000871 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 570417000872 dimer interface [polypeptide binding]; other site 570417000875 PS00636 Nt-dnaJ domain signature. 570417000878 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000879 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 570417000880 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 570417000881 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 570417000884 translocation protein TolB; Provisional; Region: tolB; PRK05137 570417000885 TolB amino-terminal domain; Region: TolB_N; cl00639 570417000886 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 570417000892 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 570417000894 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 570417000895 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 570417000898 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 570417000899 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 570417000900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 570417000901 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 570417000902 Walker A motif; other site 570417000903 ATP binding site [chemical binding]; other site 570417000904 Walker B motif; other site 570417000905 arginine finger; other site 570417000906 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 570417000911 PS00017 ATP/GTP-binding site motif A (P-loop). 570417000912 PS00674 AAA-protein family signature. 570417000913 1 probable transmembrane helix predicted for WP0228 by TMHMM2.0 at aa 619-641 570417000914 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000915 transketolase; Reviewed; Region: PRK05899 570417000916 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 570417000917 TPP-binding site [chemical binding]; other site 570417000918 dimer interface [polypeptide binding]; other site 570417000919 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 570417000920 PYR/PP interface [polypeptide binding]; other site 570417000921 dimer interface [polypeptide binding]; other site 570417000922 TPP binding site [chemical binding]; other site 570417000923 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 570417000927 PS00802 Transketolase signature 2. 570417000929 PS00801 Transketolase signature 1. 570417000930 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 570417000931 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 570417000932 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 570417000933 RNA binding surface [nucleotide binding]; other site 570417000936 Protein of unknown function (DUF528); Region: DUF528; cl01123 570417000938 1 probable transmembrane helix predicted for WP0232 by TMHMM2.0 at aa 13-35 570417000939 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417000940 Protein of unknown function (DUF721); Region: DUF721; cl02324 570417000941 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 570417000944 lipoyl synthase; Provisional; Region: PRK05481 570417000945 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 570417000946 FeS/SAM binding site; other site 570417000949 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417000951 transposase (fragment) 570417000952 Putative dna repair protein radc (fragment) 570417000953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 570417000954 non-specific DNA binding site [nucleotide binding]; other site 570417000955 salt bridge; other site 570417000956 sequence-specific DNA binding site [nucleotide binding]; other site 570417000957 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 570417000958 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 570417000959 non-specific DNA binding site [nucleotide binding]; other site 570417000960 salt bridge; other site 570417000961 sequence-specific DNA binding site [nucleotide binding]; other site 570417000964 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 570417000965 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 570417000967 prophage 1 570417000968 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 570417000969 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 570417000970 Baseplate J-like protein; Region: Baseplate_J; cl01294 570417000972 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 570417000973 Uncharacterized conserved protein [Function unknown]; Region: COG4104 570417000974 PAAR motif; Region: PAAR_motif; pfam05488 570417000975 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 570417000976 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 570417000977 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 570417000978 tandem repeat interface [polypeptide binding]; other site 570417000979 oligomer interface [polypeptide binding]; other site 570417000980 active site residues [active] 570417000981 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 570417000982 gpW; Region: gpW; pfam02831 570417000983 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 570417000984 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 570417000985 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417000986 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417000987 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417000988 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417000989 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417000990 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417000991 2 probable transmembrane helices predicted for WP0256 by TMHMM2.0 at aa 406-428 and 432-454 570417000992 ParB-like nuclease domain; Region: ParBc; cl02129 570417000993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 570417000994 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 570417000995 active site 570417000996 dimer interface [polypeptide binding]; other site 570417000997 putative DNA-binding cleft [nucleotide binding]; other site 570417000998 BRO family, N-terminal domain; Region: Bro-N; cl10591 570417000999 Archaeal ATPase; Region: Arch_ATPase; pfam01637 570417001001 PS00017 ATP/GTP-binding site motif A (P-loop). 570417001002 Integrase core domain; Region: rve; cl01316 570417001003 Putative phage related protein (pseudogene) 570417001004 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 570417001005 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 570417001006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417001007 Walker A motif; other site 570417001008 ATP binding site [chemical binding]; other site 570417001009 Walker B motif; other site 570417001010 Transposase; Region: HTH_Tnp_IS630; pfam01710 570417001011 PS00017 ATP/GTP-binding site motif A (P-loop). 570417001012 PS00017 ATP/GTP-binding site motif A (P-loop). 570417001013 Integrase core domain; Region: rve; cl01316 570417001014 1 probable transmembrane helix predicted for WP0270 by TMHMM2.0 at aa 4-21 570417001015 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 570417001016 putative active site [active] 570417001017 catalytic site [active] 570417001018 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417001019 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 570417001020 active site 570417001021 nucleophile elbow; other site 570417001023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 570417001024 non-specific DNA binding site [nucleotide binding]; other site 570417001025 salt bridge; other site 570417001026 sequence-specific DNA binding site [nucleotide binding]; other site 570417001027 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 570417001028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 570417001029 non-specific DNA binding site [nucleotide binding]; other site 570417001030 salt bridge; other site 570417001031 sequence-specific DNA binding site [nucleotide binding]; other site 570417001034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 570417001035 non-specific DNA binding site [nucleotide binding]; other site 570417001036 salt bridge; other site 570417001037 sequence-specific DNA binding site [nucleotide binding]; other site 570417001038 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 570417001039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 570417001040 non-specific DNA binding site [nucleotide binding]; other site 570417001041 salt bridge; other site 570417001042 sequence-specific DNA binding site [nucleotide binding]; other site 570417001045 hypothetical protein; Reviewed; Region: PRK00024 570417001046 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 570417001047 MPN+ (JAMM) motif; other site 570417001048 Zinc-binding site [ion binding]; other site 570417001051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 570417001052 non-specific DNA binding site [nucleotide binding]; other site 570417001053 salt bridge; other site 570417001054 sequence-specific DNA binding site [nucleotide binding]; other site 570417001055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 570417001056 non-specific DNA binding site [nucleotide binding]; other site 570417001057 salt bridge; other site 570417001058 sequence-specific DNA binding site [nucleotide binding]; other site 570417001061 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 570417001062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 570417001063 ATP binding site [chemical binding]; other site 570417001064 Mg2+ binding site [ion binding]; other site 570417001065 G-X-G motif; other site 570417001066 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 570417001067 ATP binding site [chemical binding]; other site 570417001068 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 570417001072 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 570417001073 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 570417001074 RNA/DNA hybrid binding site [nucleotide binding]; other site 570417001075 active site 570417001077 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 570417001078 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 570417001079 putative active site [active] 570417001080 putative NTP binding site [chemical binding]; other site 570417001081 putative nucleic acid binding site [nucleotide binding]; other site 570417001082 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 570417001085 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 570417001086 FAD binding pocket [chemical binding]; other site 570417001087 conserved FAD binding motif [chemical binding]; other site 570417001088 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; pfam02902 570417001089 PS00636 Nt-dnaJ domain signature. 570417001090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 570417001092 Integrase core domain; Region: rve; cl01316 570417001093 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 570417001094 transposase (pseudogene);Disrupted bu IS insertion. 570417001095 transposase (pseudogene) 570417001098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 570417001099 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 570417001100 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 570417001101 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 570417001102 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001103 ankyrin repeat protein; Provisional; Region: PHA02875 570417001104 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001105 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001106 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001107 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001108 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001109 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001110 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001111 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001122 PS00017 ATP/GTP-binding site motif A (P-loop). 570417001123 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001124 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001125 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001126 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase; Provisional; Region: PTZ00322 570417001127 PS00018 EF-hand calcium-binding domain. 570417001132 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 570417001133 Voltage-dependent potassium channel; Provisional; Region: PLN03192 570417001134 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001137 prophage 2 570417001138 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 570417001139 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 570417001140 catalytic residues [active] 570417001141 catalytic nucleophile [active] 570417001142 Presynaptic Site I dimer interface [polypeptide binding]; other site 570417001143 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 570417001144 Synaptic Flat tetramer interface [polypeptide binding]; other site 570417001145 Synaptic Site I dimer interface [polypeptide binding]; other site 570417001146 DNA binding site [nucleotide binding] 570417001147 Recombinase; Region: Recombinase; pfam07508 570417001148 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 570417001149 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001150 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001151 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001152 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001153 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 570417001154 Baseplate J-like protein; Region: Baseplate_J; cl01294 570417001155 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 570417001156 Uncharacterized conserved protein [Function unknown]; Region: COG4104 570417001157 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 570417001158 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 570417001159 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 570417001160 tandem repeat interface [polypeptide binding]; other site 570417001161 oligomer interface [polypeptide binding]; other site 570417001162 active site residues [active] 570417001163 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 570417001164 gpW; Region: gpW; pfam02831 570417001165 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 570417001166 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 570417001167 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001168 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001169 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001170 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001171 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001172 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001173 2 probable transmembrane helices predicted for WP0315 by TMHMM2.0 at aa 406-428 and 432-454 570417001174 ParB-like nuclease domain; Region: ParBc; cl02129 570417001175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 570417001176 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 570417001177 active site 570417001178 dimer interface [polypeptide binding]; other site 570417001179 putative DNA-binding cleft [nucleotide binding]; other site 570417001180 SWIM zinc finger; Region: SWIM; cl15408 570417001181 SNF2 Helicase protein; Region: DUF3670; pfam12419 570417001182 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 570417001183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 570417001184 ATP binding site [chemical binding]; other site 570417001185 putative Mg++ binding site [ion binding]; other site 570417001186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 570417001187 nucleotide binding region [chemical binding]; other site 570417001188 ATP-binding site [chemical binding]; other site 570417001193 Putative phage related protein (pseudogene) 570417001194 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 570417001195 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 570417001196 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 570417001197 prophage 3 570417001198 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 570417001199 gpW; Region: gpW; pfam02831 570417001200 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 570417001201 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 570417001202 tandem repeat interface [polypeptide binding]; other site 570417001203 oligomer interface [polypeptide binding]; other site 570417001204 active site residues [active] 570417001205 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 570417001206 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 570417001207 Uncharacterized conserved protein [Function unknown]; Region: COG4104 570417001208 PAAR motif; Region: PAAR_motif; pfam05488 570417001209 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 570417001210 Baseplate J-like protein; Region: Baseplate_J; cl01294 570417001212 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 570417001213 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 570417001214 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 570417001215 putative active site [active] 570417001216 putative NTP binding site [chemical binding]; other site 570417001217 putative nucleic acid binding site [nucleotide binding]; other site 570417001219 PS00559 Eukaryotic molybdopterin oxidoreductases signature. 570417001220 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001221 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001225 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001226 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001230 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 570417001231 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 570417001232 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 570417001233 catalytic residues [active] 570417001234 catalytic nucleophile [active] 570417001235 Presynaptic Site I dimer interface [polypeptide binding]; other site 570417001236 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 570417001237 Synaptic Flat tetramer interface [polypeptide binding]; other site 570417001238 Synaptic Site I dimer interface [polypeptide binding]; other site 570417001239 DNA binding site [nucleotide binding] 570417001240 Recombinase; Region: Recombinase; pfam07508 570417001243 transposase (pseudogene) 570417001245 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417001247 hypothetical protein (pseudogene);Similar to N-terminal of the wMel gene 570417001248 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001249 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001250 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001251 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001252 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001253 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001254 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 570417001255 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 570417001256 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417001257 1 probable transmembrane helix predicted for WP0346 by TMHMM2.0 at aa 984-1006 570417001261 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417001265 PS00141 Eukaryotic and viral aspartyl proteases active site. 570417001267 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 570417001268 HSP70 interaction site [polypeptide binding]; other site 570417001269 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001273 1 probable transmembrane helix predicted for WP0348 by TMHMM2.0 at aa 81-103 570417001274 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417001275 1 probable transmembrane helix predicted for WP0349 by TMHMM2.0 at aa 13-35 570417001276 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 570417001277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 570417001278 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417001280 ankyrin repeat domain protein;wPip_ANK19 570417001281 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 570417001282 Clp amino terminal domain; Region: Clp_N; pfam02861 570417001283 Clp amino terminal domain; Region: Clp_N; pfam02861 570417001284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 570417001285 Walker A motif; other site 570417001286 ATP binding site [chemical binding]; other site 570417001287 Walker B motif; other site 570417001288 arginine finger; other site 570417001289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 570417001290 Walker A motif; other site 570417001291 ATP binding site [chemical binding]; other site 570417001292 Walker B motif; other site 570417001293 arginine finger; other site 570417001294 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 570417001298 PS00017 ATP/GTP-binding site motif A (P-loop). 570417001299 PS00870 Chaperonins clpA/B signature 1. 570417001302 PS00017 ATP/GTP-binding site motif A (P-loop). 570417001303 PS00871 Chaperonins clpA/B signature 2. 570417001304 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 570417001306 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 570417001307 response regulator PleD; Reviewed; Region: pleD; PRK09581 570417001308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 570417001309 active site 570417001310 phosphorylation site [posttranslational modification] 570417001311 intermolecular recognition site; other site 570417001312 dimerization interface [polypeptide binding]; other site 570417001313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 570417001314 active site 570417001315 phosphorylation site [posttranslational modification] 570417001316 intermolecular recognition site; other site 570417001317 dimerization interface [polypeptide binding]; other site 570417001318 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 570417001319 metal binding site [ion binding]; metal-binding site 570417001320 active site 570417001321 I-site; other site 570417001326 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 570417001327 Recombination protein O N terminal; Region: RecO_N; pfam11967 570417001328 Recombination protein O C terminal; Region: RecO_C; pfam02565 570417001330 1 probable transmembrane helix predicted for WP0360 by TMHMM2.0 at aa 4-21 570417001331 Putative transposase (fragment) 570417001332 transposase (pseudogene) 570417001333 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417001334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 570417001335 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 570417001336 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 570417001337 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417001338 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 570417001339 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417001340 nucleotide binding region [chemical binding]; other site 570417001341 SEC-C motif; Region: SEC-C; pfam02810 570417001342 1 probable transmembrane helix predicted for WP0368 by TMHMM2.0 at aa 5-24 570417001346 PS00572 Glycosyl hydrolases family 1 active site. 570417001347 PS01312 Protein secA signatures. 570417001350 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417001352 putative transposase (fragment) 570417001353 Putative transposase (pseudogene) 570417001355 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 570417001356 PS00135 Serine proteases, trypsin family, serine active site. 570417001357 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417001359 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 570417001360 active site residues [active] 570417001361 Putative phage portal protein (pseudogene);Disrupted by IS insertion 570417001364 before all transposase DDE domain proteins 570417001365 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417001367 plasmid stabilization system (pseudogene);does not have a valid start codon 570417001368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 570417001369 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 570417001370 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 570417001371 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 570417001372 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 570417001374 12 probable transmembrane helices predicted for WP0382 by TMHMM2.0 at aa 2-21, 26-48, 69-91, 106-128, 135-157, 188-210, 217-236, 241-263, 276-294, 317-339, 359-381 and 391-413 570417001375 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417001376 Arginine repressor [Transcription]; Region: ArgR; COG1438 570417001377 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001378 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001379 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001380 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001381 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001382 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001394 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 570417001395 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 570417001396 active site 570417001400 PS01129 Rlu family of pseudouridine synthase signature. 570417001401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 570417001402 metabolite-proton symporter; Region: 2A0106; TIGR00883 570417001403 putative substrate translocation pore; other site 570417001404 11 probable transmembrane helices predicted for WP0385 by TMHMM2.0 at aa 7-29, 49-71, 78-100, 145-167, 179-201, 235-257, 270-289, 299-318, 325-347, 362-384 and 391-413 570417001407 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417001408 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 570417001409 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 570417001410 active site 570417001412 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 570417001413 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 570417001414 dimer interface [polypeptide binding]; other site 570417001415 anticodon binding site; other site 570417001416 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 570417001417 homodimer interface [polypeptide binding]; other site 570417001418 motif 1; other site 570417001419 active site 570417001420 motif 2; other site 570417001421 GAD domain; Region: GAD; pfam02938 570417001422 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 570417001423 active site 570417001424 motif 3; other site 570417001428 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 570417001430 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001431 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001432 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001437 2 probable transmembrane helices predicted for WP0388 by TMHMM2.0 at aa 394-416 and 423-445 570417001438 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 570417001439 MutS domain I; Region: MutS_I; pfam01624 570417001440 MutS domain II; Region: MutS_II; pfam05188 570417001441 MutS family domain IV; Region: MutS_IV; pfam05190 570417001442 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 570417001443 Walker A/P-loop; other site 570417001444 ATP binding site [chemical binding]; other site 570417001445 Q-loop/lid; other site 570417001446 ABC transporter signature motif; other site 570417001447 Walker B; other site 570417001448 D-loop; other site 570417001449 H-loop/switch region; other site 570417001452 PS00486 DNA mismatch repair proteins mutS family signature. 570417001453 PS00017 ATP/GTP-binding site motif A (P-loop). 570417001458 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001459 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 570417001460 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001461 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001462 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001463 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001471 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 570417001472 14 probable transmembrane helices predicted for WP0391 by TMHMM2.0 at aa 10-27, 32-53, 87-109, 155-173, 206-228, 241-260, 280-297, 304-326, 341-363, 400-422, 445-467, 487-509, 538-560 and 665-687 570417001475 transposase (pseudogene) 570417001476 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417001477 transposase (pseudogene) 570417001481 PS00636 Nt-dnaJ domain signature. 570417001482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 570417001483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 570417001484 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 570417001485 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 570417001486 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 570417001489 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417001490 PS00843 D-alanine--D-alanine ligase signature 1. 570417001492 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 570417001493 Cell division protein FtsQ; Region: FtsQ; pfam03799 570417001494 1 probable transmembrane helix predicted for WP0404 by TMHMM2.0 at aa 12-34 570417001497 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417001499 hypothetical protein (fragment) 570417001500 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001501 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417001502 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 570417001503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 570417001504 binding surface 570417001505 TPR motif; other site 570417001506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 570417001507 binding surface 570417001508 TPR motif; other site 570417001509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 570417001510 binding surface 570417001511 TPR motif; other site 570417001512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 570417001513 binding surface 570417001514 TPR motif; other site 570417001522 PS00017 ATP/GTP-binding site motif A (P-loop). 570417001525 RDD family; Region: RDD; cl00746 570417001526 RDD family; Region: RDD; cl00746 570417001528 6 probable transmembrane helices predicted for WP0409 by TMHMM2.0 at aa 13-35, 114-136, 174-196, 206-223, 258-275 and 290-308 570417001530 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 570417001531 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001532 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001533 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001534 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001535 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001536 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001537 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001538 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001539 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001552 prophage 4 570417001553 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 570417001554 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 570417001555 catalytic residues [active] 570417001556 catalytic nucleophile [active] 570417001557 Presynaptic Site I dimer interface [polypeptide binding]; other site 570417001558 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 570417001559 Synaptic Flat tetramer interface [polypeptide binding]; other site 570417001560 Synaptic Site I dimer interface [polypeptide binding]; other site 570417001561 DNA binding site [nucleotide binding] 570417001562 Recombinase; Region: Recombinase; pfam07508 570417001563 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 570417001564 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001565 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001566 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001567 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001568 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 570417001569 Baseplate J-like protein; Region: Baseplate_J; cl01294 570417001570 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 570417001571 Uncharacterized conserved protein [Function unknown]; Region: COG4104 570417001572 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 570417001573 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 570417001574 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 570417001575 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 570417001576 putative dimer interface [polypeptide binding]; other site 570417001578 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 570417001579 tandem repeat interface [polypeptide binding]; other site 570417001580 oligomer interface [polypeptide binding]; other site 570417001581 active site residues [active] 570417001583 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 570417001586 4 probable transmembrane helices predicted for WP0428 by TMHMM2.0 at aa 387-406, 421-443, 524-546 and 566-588 570417001587 ParB-like nuclease domain; Region: ParBc; cl02129 570417001588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 570417001590 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417001591 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 570417001592 active site 570417001593 putative DNA-binding cleft [nucleotide binding]; other site 570417001594 dimer interface [polypeptide binding]; other site 570417001595 Virulence protein [General function prediction only]; Region: COG3943 570417001596 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417001598 hypothetical protein; Validated; Region: PRK07078 570417001599 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 570417001600 active site 570417001601 metal binding site [ion binding]; metal-binding site 570417001602 interdomain interaction site; other site 570417001603 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417001604 Walker A motif; other site 570417001605 ATP binding site [chemical binding]; other site 570417001606 Walker B motif; other site 570417001607 PS00017 ATP/GTP-binding site motif A (P-loop). 570417001608 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 570417001609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 570417001610 PS00017 ATP/GTP-binding site motif A (P-loop). 570417001611 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417001612 Walker A motif; other site 570417001613 ATP binding site [chemical binding]; other site 570417001614 Walker B motif; other site 570417001615 putative phage related protein (pseudogene);Disrupted by IS insertion 570417001616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 570417001617 Transposase; Region: DEDD_Tnp_IS110; pfam01548 570417001618 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 570417001619 PLC-beta C terminal; Region: PLC-beta_C; pfam08703 570417001620 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 570417001621 Phage tail tube protein FII; Region: Phage_tube; cl01390 570417001623 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 570417001625 3 probable transmembrane helices predicted for WP0448 by TMHMM2.0 at aa 513-535, 542-564 and 579-601 570417001626 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 570417001628 Phage Tail Protein X; Region: Phage_tail_X; cl02088 570417001630 Phage protein D [General function prediction only]; Region: COG3500; cl12180 570417001631 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 570417001633 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001634 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001635 1 probable transmembrane helix predicted for WP0452 by TMHMM2.0 at aa 15-33 570417001638 1 probable transmembrane helix predicted for WP0453 by TMHMM2.0 at aa 7-26 570417001639 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 570417001640 putative active site [active] 570417001641 catalytic site [active] 570417001642 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417001643 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 570417001644 active site 570417001645 nucleophile elbow; other site 570417001647 2 probable transmembrane helices predicted for WP0456 by TMHMM2.0 at aa 12-34 and 38-60 570417001648 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417001649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 570417001650 non-specific DNA binding site [nucleotide binding]; other site 570417001651 salt bridge; other site 570417001652 sequence-specific DNA binding site [nucleotide binding]; other site 570417001653 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 570417001654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 570417001655 non-specific DNA binding site [nucleotide binding]; other site 570417001656 salt bridge; other site 570417001657 sequence-specific DNA binding site [nucleotide binding]; other site 570417001658 hypothetical protein; Reviewed; Region: PRK00024 570417001659 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 570417001660 MPN+ (JAMM) motif; other site 570417001661 Zinc-binding site [ion binding]; other site 570417001662 Putative transcriptional regulator (pseudogene) 570417001663 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 570417001664 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 570417001666 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001667 OTU-like cysteine protease; Region: OTU; cl14910 570417001668 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001669 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001670 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001676 1 probable transmembrane helix predicted for WP0463 by TMHMM2.0 at aa 36-58 570417001677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 570417001678 Coenzyme A binding pocket [chemical binding]; other site 570417001680 H+ Antiporter protein; Region: 2A0121; TIGR00900 570417001681 10 probable transmembrane helices predicted for WP0465 by TMHMM2.0 at aa 12-34, 49-71, 88-110, 151-173, 228-250, 260-282, 289-311, 321-343, 364-381 and 385-402 570417001682 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 570417001683 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 570417001684 nucleotide binding pocket [chemical binding]; other site 570417001685 K-X-D-G motif; other site 570417001686 catalytic site [active] 570417001687 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 570417001688 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 570417001689 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 570417001690 Dimer interface [polypeptide binding]; other site 570417001691 BRCT sequence motif; other site 570417001696 PS01056 NAD-dependent DNA ligase signature 2. 570417001698 PS01055 NAD-dependent DNA ligase signature 1. 570417001699 transposase (pseudogene);contains stop codon 570417001701 Putative transposase (pseudogene) 570417001703 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 570417001706 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 570417001707 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 570417001709 10 probable transmembrane helices predicted for WP0471 by TMHMM2.0 at aa 4-21, 34-56, 71-93, 131-153, 173-195, 207-229, 244-261, 281-303, 318-340 and 345-367 570417001710 4 probable transmembrane helices predicted for WP0472 by TMHMM2.0 at aa 12-34, 39-58, 70-92 and 107-129 570417001711 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 570417001712 FAD binding domain; Region: FAD_binding_4; pfam01565 570417001713 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 570417001717 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 570417001718 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 570417001719 domain interfaces; other site 570417001720 active site 570417001723 PS00533 Porphobilinogen deaminase cofactor-binding site. 570417001725 2 probable transmembrane helices predicted for WP0475 by TMHMM2.0 at aa 17-39 and 61-83 570417001726 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 570417001727 Protein export membrane protein; Region: SecD_SecF; cl14618 570417001728 6 probable transmembrane helices predicted for WP0476 by TMHMM2.0 at aa 5-27, 345-363, 368-390, 395-417, 445-467 and 471-493 570417001733 Surface antigen; Region: Surface_Ag_2; cl01155 570417001735 1 probable transmembrane helix predicted for WP0477 by TMHMM2.0 at aa 7-24 570417001736 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 570417001737 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 570417001738 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 570417001739 FeS/SAM binding site; other site 570417001743 PS01278 Uncharacterized protein family UPF0004 signature. 570417001745 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 570417001746 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 570417001747 generic binding surface II; other site 570417001748 ssDNA binding site; other site 570417001749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 570417001750 ATP binding site [chemical binding]; other site 570417001751 putative Mg++ binding site [ion binding]; other site 570417001752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 570417001753 nucleotide binding region [chemical binding]; other site 570417001754 ATP-binding site [chemical binding]; other site 570417001757 PS00017 ATP/GTP-binding site motif A (P-loop). 570417001759 putative transposase (fragment) 570417001760 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 570417001762 Domain of unknown function (DUF299); Region: DUF299; cl00780 570417001765 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 570417001766 6 probable transmembrane helices predicted for WP0487 by TMHMM2.0 at aa 16-38, 58-80, 87-109, 119-141, 153-175 and 195-217 570417001768 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417001770 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 570417001771 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 570417001772 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 570417001774 GMP synthase; Reviewed; Region: guaA; PRK00074 570417001775 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 570417001776 AMP/PPi binding site [chemical binding]; other site 570417001777 candidate oxyanion hole; other site 570417001778 catalytic triad [active] 570417001779 potential glutamine specificity residues [chemical binding]; other site 570417001780 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 570417001781 ATP Binding subdomain [chemical binding]; other site 570417001782 Ligand Binding sites [chemical binding]; other site 570417001783 Dimerization subdomain; other site 570417001786 PS00442 Glutamine amidotransferases class-I active site. 570417001789 Integral membrane protein TerC family; Region: TerC; cl10468 570417001790 6 probable transmembrane helices predicted for WP0493 by TMHMM2.0 at aa 6-28, 41-63, 83-105, 118-140, 150-169 and 182-204 570417001792 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 570417001794 PS00422 Granins signature 1. 570417001795 GTP-binding protein LepA; Provisional; Region: PRK05433 570417001796 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 570417001797 G1 box; other site 570417001798 putative GEF interaction site [polypeptide binding]; other site 570417001799 GTP/Mg2+ binding site [chemical binding]; other site 570417001800 Switch I region; other site 570417001801 G2 box; other site 570417001802 G3 box; other site 570417001803 Switch II region; other site 570417001804 G4 box; other site 570417001805 G5 box; other site 570417001806 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 570417001807 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 570417001808 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 570417001812 PS00017 ATP/GTP-binding site motif A (P-loop). 570417001813 PS00301 GTP-binding elongation factors signature. 570417001817 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 570417001818 GSH binding site [chemical binding]; other site 570417001819 catalytic residues [active] 570417001822 PS00195 Glutaredoxin active site. 570417001823 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 570417001824 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 570417001825 active site 570417001826 Riboflavin kinase; Region: Flavokinase; cl03312 570417001830 lipoprotein signal peptidase; Provisional; Region: PRK14787 570417001831 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 570417001834 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417001835 3 probable transmembrane helices predicted for WP0500 by TMHMM2.0 at aa 58-80, 87-109 and 124-146 570417001836 PS00855 Signal peptidases II signature. 570417001837 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 570417001838 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 570417001839 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 570417001840 1 probable transmembrane helix predicted for WP0501 by TMHMM2.0 at aa 5-27 570417001843 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 570417001844 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 570417001845 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 570417001848 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 570417001849 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 570417001850 active site 570417001851 substrate binding site [chemical binding]; other site 570417001852 cosubstrate binding site; other site 570417001853 catalytic site [active] 570417001856 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 570417001858 2 probable transmembrane helices predicted for WP0505 by TMHMM2.0 at aa 13-47 and 67-89 570417001859 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 570417001860 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001861 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001862 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417001863 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417001871 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 570417001872 SmpB-tmRNA interface; other site 570417001875 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 570417001878 7 probable transmembrane helices predicted for WP0508 by TMHMM2.0 at aa 15-34, 46-68, 88-105, 112-134, 172-189, 194-216 and 231-253 570417001879 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417001880 PS01311 Prolipoprotein diacylglyceryl transferase signature. 570417001881 nuclease NucT; Provisional; Region: PRK13912 570417001882 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 570417001883 putative active site [active] 570417001884 catalytic site [active] 570417001885 1 probable transmembrane helix predicted for WP0510 by TMHMM2.0 at aa 2-24 570417001886 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 570417001889 Domain of Unknown Function with PDB structure; Region: DUF3857; pfam12969 570417001890 PS00213 Lipocalin signature. 570417001891 PS00037 Myb DNA-binding domain repeat signature 1. 570417001892 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 570417001893 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 570417001894 catalytic residues [active] 570417001895 1 probable transmembrane helix predicted for WP0513 by TMHMM2.0 at aa 4-26 570417001897 Transposase, Mutator family; Region: Transposase_mut; pfam00872 570417001898 MULE transposase domain; Region: MULE; pfam10551 570417001900 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417001901 conserved hypothetical protein (pseudogene);Disrupted by IS insertion 570417001902 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417001904 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417001905 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 570417001906 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 570417001907 TPP-binding site [chemical binding]; other site 570417001908 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 570417001909 dimer interface [polypeptide binding]; other site 570417001910 PYR/PP interface [polypeptide binding]; other site 570417001911 TPP binding site [chemical binding]; other site 570417001915 PS00017 ATP/GTP-binding site motif A (P-loop). 570417001916 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 570417001917 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 570417001918 active site 570417001919 HIGH motif; other site 570417001920 dimer interface [polypeptide binding]; other site 570417001921 KMSKS motif; other site 570417001924 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 570417001925 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 570417001926 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 570417001927 dimer interface [polypeptide binding]; other site 570417001928 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 570417001930 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 570417001931 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 570417001932 substrate binding pocket [chemical binding]; other site 570417001933 chain length determination region; other site 570417001934 substrate-Mg2+ binding site; other site 570417001935 catalytic residues [active] 570417001936 aspartate-rich region 1; other site 570417001937 active site lid residues [active] 570417001938 aspartate-rich region 2; other site 570417001940 PS00444 Polyprenyl synthetases signature 2. 570417001941 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 570417001944 PS00732 Ribosomal protein S16 signature. 570417001945 periplasmic folding chaperone; Provisional; Region: PRK10788 570417001946 PPIC-type PPIASE domain; Region: Rotamase; cl08278 570417001947 1 probable transmembrane helix predicted for WP0526 by TMHMM2.0 at aa 7-29 570417001948 putative transposase (pseudogene) 570417001949 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 570417001951 transcription termination factor Rho; Provisional; Region: rho; PRK09376 570417001952 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 570417001953 RNA binding site [nucleotide binding]; other site 570417001954 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 570417001955 multimer interface [polypeptide binding]; other site 570417001956 Walker A motif; other site 570417001957 ATP binding site [chemical binding]; other site 570417001958 Walker B motif; other site 570417001963 PS00017 ATP/GTP-binding site motif A (P-loop). 570417001964 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 570417001965 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 570417001966 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 570417001967 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 570417001968 active site 570417001971 PS00487 IMP dehydrogenase / GMP reductase signature. 570417001973 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417001974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 570417001975 S-adenosylmethionine binding site [chemical binding]; other site 570417001978 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 570417001979 substrate binding site [chemical binding]; other site 570417001980 dimer interface [polypeptide binding]; other site 570417001981 catalytic triad [active] 570417001984 PS00171 Triosephosphate isomerase active site. 570417001985 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 570417001986 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 570417001987 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 570417001989 PS00017 ATP/GTP-binding site motif A (P-loop). 570417001991 PS01011 Folylpolyglutamate synthase signature 1. 570417001993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 570417001996 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417001998 Putative transposase (pseudogene) 570417001999 2 probable transmembrane helices predicted for WP0539 by TMHMM2.0 at aa 21-43 and 76-98 570417002000 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 570417002002 Putative transposase (pseudogene) 570417002003 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 570417002004 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 570417002005 purine monophosphate binding site [chemical binding]; other site 570417002006 dimer interface [polypeptide binding]; other site 570417002007 putative catalytic residues [active] 570417002008 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 570417002009 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 570417002013 Putative transposase (fragment) 570417002014 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 570417002015 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 570417002016 minor groove reading motif; other site 570417002017 helix-hairpin-helix signature motif; other site 570417002018 substrate binding pocket [chemical binding]; other site 570417002019 active site 570417002020 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 570417002021 PS00764 Endonuclease III iron-sulfur binding region signature. 570417002025 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 570417002026 HSP70 interaction site [polypeptide binding]; other site 570417002027 4 probable transmembrane helices predicted for WP0546 by TMHMM2.0 at aa 222-241, 245-267, 294-314 and 319-341 570417002028 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002030 isocitrate dehydrogenase; Validated; Region: PRK09222 570417002031 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 570417002033 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 570417002034 Putative rdd domain membrane protein (pseudogene);Disrupted by IS insertion 570417002035 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417002036 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 570417002037 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 570417002038 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 570417002039 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 570417002042 PS00184 Phosphoribosylglycinamide synthetase signature. 570417002045 seryl-tRNA synthetase; Provisional; Region: PRK05431 570417002046 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 570417002047 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 570417002048 dimer interface [polypeptide binding]; other site 570417002049 active site 570417002050 motif 1; other site 570417002051 motif 2; other site 570417002052 motif 3; other site 570417002055 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 570417002057 2 probable transmembrane helices predicted for WP0552 by TMHMM2.0 at aa 26-48 and 52-74 570417002058 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 570417002059 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 570417002060 FMN binding site [chemical binding]; other site 570417002061 active site 570417002062 catalytic residues [active] 570417002063 substrate binding site [chemical binding]; other site 570417002066 PS01136 Uncharacterized protein family UPF0034 signature. 570417002067 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Provisional; Region: PRK14844 570417002068 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 570417002069 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 570417002070 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 570417002071 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 570417002072 RPB11 interaction site [polypeptide binding]; other site 570417002073 RPB12 interaction site [polypeptide binding]; other site 570417002074 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 570417002075 RPB3 interaction site [polypeptide binding]; other site 570417002076 RPB11 interaction site [polypeptide binding]; other site 570417002077 RPB12 interaction site [polypeptide binding]; other site 570417002078 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 570417002079 RPB1 interaction site [polypeptide binding]; other site 570417002080 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 570417002081 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 570417002082 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 570417002083 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 570417002084 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 570417002085 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 570417002086 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 570417002087 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 570417002088 DNA binding site [nucleotide binding] 570417002089 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 570417002099 PS01166 RNA polymerases beta chain signature. 570417002103 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 570417002104 peripheral dimer interface [polypeptide binding]; other site 570417002105 core dimer interface [polypeptide binding]; other site 570417002106 L10 interface [polypeptide binding]; other site 570417002107 L11 interface [polypeptide binding]; other site 570417002108 putative EF-Tu interaction site [polypeptide binding]; other site 570417002109 putative EF-G interaction site [polypeptide binding]; other site 570417002111 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 570417002112 23S rRNA interface [nucleotide binding]; other site 570417002113 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 570417002115 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 570417002116 mRNA/rRNA interface [nucleotide binding]; other site 570417002119 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 570417002120 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 570417002121 23S rRNA interface [nucleotide binding]; other site 570417002122 L7/L12 interface [polypeptide binding]; other site 570417002123 putative thiostrepton binding site; other site 570417002124 L25 interface [polypeptide binding]; other site 570417002125 PS00359 Ribosomal protein L11 signature. 570417002128 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 570417002129 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 570417002130 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 570417002131 putative homodimer interface [polypeptide binding]; other site 570417002132 KOW motif; Region: KOW; cl00354 570417002135 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 570417002136 1 probable transmembrane helix predicted for WP0560 by TMHMM2.0 at aa 29-51 570417002137 elongation factor Tu; Reviewed; Region: PRK00049 570417002138 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 570417002139 G1 box; other site 570417002140 GEF interaction site [polypeptide binding]; other site 570417002141 GTP/Mg2+ binding site [chemical binding]; other site 570417002142 Switch I region; other site 570417002143 G2 box; other site 570417002144 G3 box; other site 570417002145 Switch II region; other site 570417002146 G4 box; other site 570417002147 G5 box; other site 570417002148 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 570417002149 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 570417002150 Antibiotic Binding Site [chemical binding]; other site 570417002156 PS00301 GTP-binding elongation factors signature. 570417002157 PS00017 ATP/GTP-binding site motif A (P-loop). 570417002158 elongation factor G; Reviewed; Region: PRK00007 570417002159 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 570417002160 G1 box; other site 570417002161 putative GEF interaction site [polypeptide binding]; other site 570417002162 GTP/Mg2+ binding site [chemical binding]; other site 570417002163 Switch I region; other site 570417002164 G2 box; other site 570417002165 G3 box; other site 570417002166 Switch II region; other site 570417002167 G4 box; other site 570417002168 G5 box; other site 570417002169 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 570417002170 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 570417002171 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 570417002178 PS00301 GTP-binding elongation factors signature. 570417002179 PS00017 ATP/GTP-binding site motif A (P-loop). 570417002180 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 570417002183 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 570417002184 S17 interaction site [polypeptide binding]; other site 570417002185 S8 interaction site; other site 570417002186 16S rRNA interaction site [nucleotide binding]; other site 570417002187 streptomycin interaction site [chemical binding]; other site 570417002188 23S rRNA interaction site [nucleotide binding]; other site 570417002189 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 570417002192 PS00055 Ribosomal protein S12 signature. 570417002193 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 570417002194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 570417002196 PS00237 G-protein coupled receptors signature. 570417002197 PS00092 N-6 Adenine-specific DNA methylases signature. 570417002198 putative transposase (fragment) 570417002199 Putative transposase (fragment) 570417002200 BON domain; Region: BON; cl02771 570417002201 BON domain; Region: BON; cl02771 570417002204 1 probable transmembrane helix predicted for WP0568 by TMHMM2.0 at aa 7-29 570417002205 trigger factor; Region: tig; TIGR00115 570417002206 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 570417002207 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 570417002211 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 570417002212 oligomer interface [polypeptide binding]; other site 570417002213 active site residues [active] 570417002216 PS00381 Endopeptidase Clp serine active site. 570417002217 PS00382 Endopeptidase Clp histidine active site. 570417002218 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 570417002219 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 570417002220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 570417002221 Walker A motif; other site 570417002222 ATP binding site [chemical binding]; other site 570417002223 Walker B motif; other site 570417002224 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 570417002229 PS00017 ATP/GTP-binding site motif A (P-loop). 570417002230 Found in ATP-dependent protease La (LON); Region: LON; smart00464 570417002231 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 570417002232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 570417002233 Walker A motif; other site 570417002234 ATP binding site [chemical binding]; other site 570417002235 Walker B motif; other site 570417002236 arginine finger; other site 570417002237 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 570417002242 PS00017 ATP/GTP-binding site motif A (P-loop). 570417002244 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 570417002245 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 570417002246 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 570417002249 1 probable transmembrane helix predicted for WP0573 by TMHMM2.0 at aa 13-35 570417002250 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002251 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 570417002253 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 570417002254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417002258 PS00017 ATP/GTP-binding site motif A (P-loop). 570417002259 2 probable transmembrane helices predicted for WP0576 by TMHMM2.0 at aa 35-57 and 84-106 570417002260 cell division protein FtsZ; Validated; Region: PRK09330 570417002261 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 570417002262 nucleotide binding site [chemical binding]; other site 570417002263 SulA interaction site; other site 570417002266 PS01134 FtsZ protein signature 1. 570417002267 PS01135 FtsZ protein signature 2. 570417002269 EVE domain; Region: EVE; cl00728 570417002271 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 570417002274 PS01306 Uncharacterized protein family UPF0054 signature. 570417002275 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 570417002277 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 570417002278 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 570417002279 PS00268 Cecropin family signature. 570417002280 1 probable transmembrane helix predicted for WP0581 by TMHMM2.0 at aa 2-21 570417002281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 570417002282 Coenzyme A binding pocket [chemical binding]; other site 570417002284 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 570417002285 tetramer interfaces [polypeptide binding]; other site 570417002286 binuclear metal-binding site [ion binding]; other site 570417002287 5 probable transmembrane helices predicted for WP0583 by TMHMM2.0 at aa 20-37, 42-64, 74-93, 100-122 and 137-159 570417002289 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14620 570417002290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417002291 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 570417002294 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 570417002295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 570417002296 active site 570417002297 phosphorylation site [posttranslational modification] 570417002298 intermolecular recognition site; other site 570417002299 dimerization interface [polypeptide binding]; other site 570417002300 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 570417002301 DNA binding site [nucleotide binding] 570417002304 conserved hypothetical protein (pseudogene);Aligment with wMel orto has large gaps; Disrupted by IS insertion 570417002305 putative transposase (pseudogene) 570417002306 PS00017 ATP/GTP-binding site motif A (P-loop). 570417002307 PS00017 ATP/GTP-binding site motif A (P-loop). 570417002308 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 570417002309 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 570417002310 putative dimer interface [polypeptide binding]; other site 570417002311 [2Fe-2S] cluster binding site [ion binding]; other site 570417002314 PS01099 Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. 570417002315 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 570417002319 hypothetical protein (pseudogene) 570417002320 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 570417002321 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 570417002322 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 570417002325 PS00143 Insulinase family, zinc-binding region signature. 570417002326 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 570417002327 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 570417002328 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 570417002330 PS00088 Manganese and iron superoxide dismutases signature. 570417002332 2 probable transmembrane helices predicted for WP0593 by TMHMM2.0 at aa 65-87 and 130-152 570417002333 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417002335 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417002337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 570417002338 S-adenosylmethionine binding site [chemical binding]; other site 570417002341 PS00092 N-6 Adenine-specific DNA methylases signature. 570417002342 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 570417002343 PS00079 Multicopper oxidases signature 1. 570417002345 6 probable transmembrane helices predicted for WP0599 by TMHMM2.0 at aa 345-367, 374-396, 464-486, 493-515, 530-552 and 800-819 570417002346 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002347 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 570417002349 7 probable transmembrane helices predicted for WP0600 by TMHMM2.0 at aa 590-612, 633-652, 685-707, 720-742, 757-774, 781-803 and 841-863 570417002350 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002351 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 570417002353 5 probable transmembrane helices predicted for WP0601 by TMHMM2.0 at aa 464-486, 565-587, 602-624, 637-659 and 688-710 570417002354 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002355 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 570417002357 9 probable transmembrane helices predicted for WP0602 by TMHMM2.0 at aa 7-29, 63-85, 92-114, 437-459, 568-590, 594-616, 618-640, 655-674 and 756-778 570417002358 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002359 PS00139 Eukaryotic thiol (cysteine) proteases cysteine active site. 570417002360 type IV secretion system ATPase VirB4; Provisional; Region: PRK13898 570417002361 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 570417002362 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417002363 Walker A/P-loop; other site 570417002364 ATP binding site [chemical binding]; other site 570417002365 Q-loop/lid; other site 570417002367 PS00017 ATP/GTP-binding site motif A (P-loop). 570417002369 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 570417002371 1 probable transmembrane helix predicted for WP0604 by TMHMM2.0 at aa 21-43 570417002372 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 570417002373 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 570417002374 active site 570417002375 nucleotide binding site [chemical binding]; other site 570417002376 HIGH motif; other site 570417002377 KMSKS motif; other site 570417002380 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 570417002381 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002382 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002383 2 probable transmembrane helices predicted for WP0606 by TMHMM2.0 at aa 149-171 and 181-203 570417002384 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002387 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 570417002388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 570417002389 S-adenosylmethionine binding site [chemical binding]; other site 570417002391 Protein of unknown function (DUF2497); Region: DUF2497; cl11534 570417002392 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 570417002395 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002396 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 570417002397 23S rRNA interface [nucleotide binding]; other site 570417002398 L3 interface [polypeptide binding]; other site 570417002401 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 570417002403 PS00360 Ribosomal protein S9 signature. 570417002404 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 570417002405 IHF - DNA interface [nucleotide binding]; other site 570417002406 IHF dimer interface [polypeptide binding]; other site 570417002408 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 570417002409 active site 570417002410 hydrophilic channel; other site 570417002411 dimerization interface [polypeptide binding]; other site 570417002412 catalytic residues [active] 570417002413 active site lid [active] 570417002415 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 570417002416 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 570417002417 putative dimer interface [polypeptide binding]; other site 570417002419 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 570417002420 catalytic core domain of glutamyl-tRNA and glutaminyl-tRNA synthetase; Region: GlxRS_core; cd00418 570417002421 active site 570417002422 HIGH motif; other site 570417002423 KMSKS motif; other site 570417002426 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 570417002427 2 probable transmembrane helices predicted for WP0616 by TMHMM2.0 at aa 138-160 and 165-184 570417002428 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 570417002429 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 570417002430 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 570417002431 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 570417002432 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 570417002433 carboxyltransferase (CT) interaction site; other site 570417002434 biotinylation site [posttranslational modification]; other site 570417002435 PS00430 TonB-dependent receptor proteins signature 1. 570417002439 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 570417002440 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 570417002443 PS00188 Biotin-requiring enzymes attachment site. 570417002444 cytochrome c oxidase assembly protein; Provisional; Region: PTZ00127 570417002445 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 570417002447 8 probable transmembrane helices predicted for WP0618 by TMHMM2.0 at aa 7-29, 91-110, 117-139, 154-173, 193-215, 249-271, 278-300 and 305-327 570417002448 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 570417002449 DXD motif; other site 570417002450 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 570417002451 5 probable transmembrane helices predicted for WP0619 by TMHMM2.0 at aa 105-124, 128-150, 425-447, 457-476 and 483-505 570417002453 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002454 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 570417002455 1 probable transmembrane helix predicted for WP0620 by TMHMM2.0 at aa 4-26 570417002456 Plant ATP synthase F0; Region: YMF19; cl07975 570417002458 1 probable transmembrane helix predicted for WP0621 by TMHMM2.0 at aa 13-32 570417002459 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002460 ATP synthase subunit C; Region: ATP-synt_C; cl00466 570417002463 2 probable transmembrane helices predicted for WP0622 by TMHMM2.0 at aa 15-37 and 50-72 570417002464 PS00605 ATP synthase c subunit signature. 570417002465 ATP synthase A chain; Region: ATP-synt_A; cl00413 570417002468 7 probable transmembrane helices predicted for WP0623 by TMHMM2.0 at aa 27-49, 54-76, 86-108, 115-134, 149-168, 181-203 and 208-230 570417002469 PS00449 ATP synthase a subunit signature. 570417002470 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002471 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 570417002472 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 570417002473 putative tRNA-binding site [nucleotide binding]; other site 570417002474 B3/4 domain; Region: B3_4; cl11458 570417002475 tRNA synthetase B5 domain; Region: B5; cl08394 570417002476 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 570417002477 dimer interface [polypeptide binding]; other site 570417002478 motif 1; other site 570417002479 motif 3; other site 570417002480 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 570417002486 putative membrane protein (pseudogene) 570417002487 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 570417002488 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 570417002489 HIGH motif; other site 570417002490 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 570417002491 active site 570417002492 KMSKS motif; other site 570417002493 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 570417002494 tRNA binding surface [nucleotide binding]; other site 570417002495 anticodon binding site; other site 570417002499 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 570417002500 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 570417002501 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 570417002502 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 570417002503 FeS/SAM binding site; other site 570417002504 TRAM domain; Region: TRAM; cl01282 570417002509 PS01278 Uncharacterized protein family UPF0004 signature. 570417002511 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 570417002512 DHH family; Region: DHH; pfam01368 570417002513 DHHA1 domain; Region: DHHA1; pfam02272 570417002517 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 570417002520 PS00503 Pectinesterase signature 2. 570417002521 PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 570417002522 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 570417002524 4 probable transmembrane helices predicted for WP0632 by TMHMM2.0 at aa 12-31, 46-68, 89-111 and 141-163 570417002525 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 570417002526 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 570417002527 FMN binding site [chemical binding]; other site 570417002528 substrate binding site [chemical binding]; other site 570417002529 putative catalytic residue [active] 570417002531 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002532 2 probable transmembrane helices predicted for WP0634 by TMHMM2.0 at aa 416-438 and 442-464 570417002533 2 probable transmembrane helices predicted for WP0635 by TMHMM2.0 at aa 5-22 and 63-85 570417002534 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002535 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 570417002536 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 570417002538 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002539 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417002540 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 570417002541 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002542 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417002543 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002544 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417002553 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 570417002554 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 570417002555 putative NAD(P) binding site [chemical binding]; other site 570417002556 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 570417002557 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 570417002559 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 570417002560 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 570417002561 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 570417002562 active site 570417002564 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 570417002565 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 570417002568 PS01281 Glucose inhibited division protein A family signature 2. 570417002569 4 probable transmembrane helices predicted for WP0644 by TMHMM2.0 at aa 2-21, 31-53, 66-88 and 98-120 570417002570 MviN-like protein; Region: MVIN; pfam03023 570417002572 13 probable transmembrane helices predicted for WP0645 by TMHMM2.0 at aa 20-42, 81-103, 118-140, 152-174, 179-201, 227-249, 264-281, 301-323, 333-355, 368-390, 395-417, 429-451 and 466-488 570417002574 1 probable transmembrane helix predicted for WP0647 by TMHMM2.0 at aa 5-24 570417002575 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002576 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417002581 Phage-related protein [Function unknown]; Region: COG4695; cl01923 570417002582 Phage portal protein; Region: Phage_portal; pfam04860 570417002585 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 570417002588 PS01313 Lipoate-protein ligase B signature. 570417002589 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 570417002590 dimer interface [polypeptide binding]; other site 570417002591 catalytic triad [active] 570417002593 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002594 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417002595 2 probable transmembrane helices predicted for WP0652 by TMHMM2.0 at aa 207-229 and 233-255 570417002596 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002598 PS00017 ATP/GTP-binding site motif A (P-loop). 570417002602 putative transposase (pseudogene) 570417002603 adenylosuccinate lyase; Provisional; Region: PRK07492 570417002604 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 570417002605 tetramer interface [polypeptide binding]; other site 570417002606 active site 570417002609 PS00163 Fumarate lyases signature. 570417002610 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 570417002611 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 570417002612 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 570417002616 PS00651 Ribosomal protein L9 signature. 570417002617 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 570417002620 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 570417002623 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 570417002624 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 570417002625 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 570417002626 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 570417002627 generic binding surface II; other site 570417002628 generic binding surface I; other site 570417002633 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002634 putative transposase (pseudogene);Disrupted by IS insertion. 570417002635 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417002637 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 570417002638 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 570417002639 putative active site [active] 570417002640 substrate binding site [chemical binding]; other site 570417002641 putative cosubstrate binding site; other site 570417002642 catalytic site [active] 570417002643 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 570417002644 substrate binding site [chemical binding]; other site 570417002648 ribosomal protein L20; Region: rpl20; CHL00068 570417002649 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 570417002650 23S rRNA binding site [nucleotide binding]; other site 570417002651 L21 binding site [polypeptide binding]; other site 570417002652 L13 binding site [polypeptide binding]; other site 570417002655 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 570417002658 1 probable transmembrane helix predicted for WP0665 by TMHMM2.0 at aa 192-211 570417002659 1 probable transmembrane helix predicted for WP0666 by TMHMM2.0 at aa 243-265 570417002660 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 570417002661 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 570417002662 motif 1; other site 570417002663 active site 570417002664 motif 2; other site 570417002665 motif 3; other site 570417002666 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 570417002669 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 570417002672 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 570417002673 Leucine-rich repeats; other site 570417002674 Substrate binding site [chemical binding]; other site 570417002677 Sulfatase; Region: Sulfatase; cl10460 570417002678 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 570417002681 PS00017 ATP/GTP-binding site motif A (P-loop). 570417002683 Acyl transferase domain; Region: Acyl_transf_1; cl08282 570417002684 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 570417002687 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 570417002688 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 570417002690 4 probable transmembrane helices predicted for WP0674 by TMHMM2.0 at aa 151-170, 180-202, 291-313 and 328-350 570417002691 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002692 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002693 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002694 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 570417002695 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 570417002696 1 probable transmembrane helix predicted for WP0675 by TMHMM2.0 at aa 5-22 570417002698 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 570417002699 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 570417002700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417002703 PS00097 Aspartate and ornithine carbamoyltransferases signature. 570417002705 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002707 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 570417002708 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 570417002709 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 570417002710 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 570417002711 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 570417002721 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 570417002722 catalytic site [active] 570417002723 G-X2-G-X-G-K; other site 570417002724 PS00856 Guanylate kinase signature. 570417002726 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002727 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002732 2 probable transmembrane helices predicted for WP0680 by TMHMM2.0 at aa 549-568 and 573-595 570417002733 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002734 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 570417002735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417002736 domain; Region: Succ_DH_flav_C; pfam02910 570417002741 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 570417002742 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002743 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 570417002744 1 probable transmembrane helix predicted for WP0682 by TMHMM2.0 at aa 61-83 570417002746 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 570417002747 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 570417002748 trimer interface [polypeptide binding]; other site 570417002749 active site 570417002750 substrate binding site [chemical binding]; other site 570417002751 CoA binding site [chemical binding]; other site 570417002758 Protein of unknown function (DUF2610); Region: DUF2610; pfam11020 570417002759 Uncharacterized conserved protein [Function unknown]; Region: COG1565 570417002760 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 570417002762 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002763 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417002764 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002765 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417002766 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417002767 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002768 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417002769 1 probable transmembrane helix predicted for WP0688 by TMHMM2.0 at aa 405-427 570417002780 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002781 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417002782 ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; Region: RPT1; COG1222 570417002783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 570417002784 Walker A motif; other site 570417002785 ATP binding site [chemical binding]; other site 570417002786 Walker B motif; other site 570417002787 arginine finger; other site 570417002789 PS00017 ATP/GTP-binding site motif A (P-loop). 570417002790 2 probable transmembrane helices predicted for WP0689 by TMHMM2.0 at aa 187-209 and 216-238 570417002794 putative transposase (pseudogene) 570417002795 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 570417002796 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 570417002797 metal binding site [ion binding]; metal-binding site 570417002798 dimer interface [polypeptide binding]; other site 570417002802 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 570417002803 active site 570417002804 metal binding site [ion binding]; metal-binding site 570417002806 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 570417002807 3 probable transmembrane helices predicted for WP0693 by TMHMM2.0 at aa 7-25, 35-57 and 69-91 570417002808 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002809 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 570417002810 folate binding site [chemical binding]; other site 570417002811 NADP+ binding site [chemical binding]; other site 570417002813 PS00075 Dihydrofolate reductase signature. 570417002814 folate synthesis bifunctional protein (pseudogene) 570417002816 PS00792 Dihydropteroate synthase signature 1. 570417002819 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. 570417002820 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 570417002821 active site 570417002824 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 570417002826 Putative SdbB protein homolog (pseudogene) 570417002827 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 570417002828 catalytic residues [active] 570417002831 PS00194 Thioredoxin family active site. 570417002832 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 570417002833 putative active site [active] 570417002834 catalytic site [active] 570417002835 putative substrate binding site [chemical binding]; other site 570417002837 4 probable transmembrane helices predicted for WP0704 by TMHMM2.0 at aa 7-29, 33-55, 62-84 and 99-121 570417002838 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002839 GTPase Era; Reviewed; Region: era; PRK00089 570417002840 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 570417002841 G1 box; other site 570417002842 GTP/Mg2+ binding site [chemical binding]; other site 570417002843 Switch I region; other site 570417002844 G2 box; other site 570417002845 Switch II region; other site 570417002846 G3 box; other site 570417002847 G4 box; other site 570417002848 G5 box; other site 570417002849 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 570417002853 PS00017 ATP/GTP-binding site motif A (P-loop). 570417002855 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 570417002856 active site 570417002857 catalytic site [active] 570417002858 substrate binding site [chemical binding]; other site 570417002859 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 570417002860 active site flap/lid [active] 570417002861 nucleophilic elbow; other site 570417002862 catalytic triad [active] 570417002864 PS00120 Lipases, serine active site. 570417002865 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 570417002866 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 570417002867 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 570417002869 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 570417002870 2 probable transmembrane helices predicted for WP0715 by TMHMM2.0 at aa 70-89 and 99-121 570417002871 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002872 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 570417002873 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 570417002874 active site residue [active] 570417002876 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 570417002877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 570417002878 dimer interface [polypeptide binding]; other site 570417002879 conserved gate region; other site 570417002880 putative PBP binding loops; other site 570417002881 ABC-ATPase subunit interface; other site 570417002882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 570417002883 11 probable transmembrane helices predicted for WP0717 by TMHMM2.0 at aa 9-31, 51-73, 86-104, 137-159, 166-188, 233-252, 284-306, 326-348, 361-383, 393-412 and 507-526 570417002886 Protein of unknown function (DUF525); Region: DUF525; cl01119 570417002888 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 570417002889 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 570417002893 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 570417002894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417002895 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 570417002899 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 570417002900 Amino acid permease; Region: AA_permease; cl00524 570417002902 11 probable transmembrane helices predicted for WP0722 by TMHMM2.0 at aa 5-27, 34-56, 85-107, 120-139, 144-166, 186-208, 223-245, 266-288, 315-337, 350-372 and 397-419 570417002903 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 570417002904 Amino acid permease; Region: AA_permease; cl00524 570417002906 12 probable transmembrane helices predicted for WP0723 by TMHMM2.0 at aa 7-29, 39-61, 82-104, 119-138, 145-167, 187-209, 222-244, 268-290, 316-335, 345-367, 379-398 and 402-419 570417002907 4 probable transmembrane helices predicted for WP0724 by TMHMM2.0 at aa 10-32, 52-71, 114-136 and 149-171 570417002908 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002909 Survival protein SurE; Region: SurE; cl00448 570417002912 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 570417002913 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 570417002914 dimer interface [polypeptide binding]; other site 570417002915 motif 1; other site 570417002916 active site 570417002917 motif 2; other site 570417002918 motif 3; other site 570417002919 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 570417002920 anticodon binding site; other site 570417002924 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 570417002925 NifU-like domain; Region: NifU; cl00484 570417002927 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 570417002928 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 570417002929 HSP70 interaction site [polypeptide binding]; other site 570417002930 1 probable transmembrane helix predicted for WP0728 by TMHMM2.0 at aa 5-27 570417002932 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002935 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002936 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417002940 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002941 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417002942 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417002944 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417002945 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417002946 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417002952 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 570417002953 Qi binding site; other site 570417002954 intrachain domain interface; other site 570417002955 interchain domain interface [polypeptide binding]; other site 570417002956 cytochrome b; Provisional; Region: CYTB; MTH00191 570417002957 heme bH binding site [chemical binding]; other site 570417002958 heme bL binding site [chemical binding]; other site 570417002959 Qo binding site; other site 570417002960 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 570417002961 interchain domain interface [polypeptide binding]; other site 570417002962 intrachain domain interface; other site 570417002963 Qi binding site; other site 570417002964 Qo binding site; other site 570417002966 9 probable transmembrane helices predicted for WP0734 by TMHMM2.0 at aa 44-66, 91-113, 128-150, 157-179, 194-216, 248-270, 306-325, 338-356 and 366-388 570417002967 PS00192 Cytochrome b/b6 heme-ligand signature. 570417002969 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 570417002971 1 probable transmembrane helix predicted for WP0735 by TMHMM2.0 at aa 226-245 570417002972 excinuclease ABC subunit B; Provisional; Region: PRK05298 570417002973 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 570417002974 ATP binding site [chemical binding]; other site 570417002975 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 570417002976 nucleotide binding region [chemical binding]; other site 570417002977 ATP-binding site [chemical binding]; other site 570417002978 Ultra-violet resistance protein B; Region: UvrB; pfam12344 570417002980 PS00017 ATP/GTP-binding site motif A (P-loop). 570417002982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 570417002983 Major Facilitator Superfamily; Region: MFS_1; pfam07690 570417002984 putative substrate translocation pore; other site 570417002985 11 probable transmembrane helices predicted for WP0737 by TMHMM2.0 at aa 7-29, 73-89, 96-118, 133-155, 162-181, 215-237, 250-272, 282-304, 306-328, 343-362 and 369-386 570417002987 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 570417002988 IHF dimer interface [polypeptide binding]; other site 570417002989 IHF - DNA interface [nucleotide binding]; other site 570417002991 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 570417002992 DNA binding residues [nucleotide binding] 570417002994 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 570417002995 Peptidase family M23; Region: Peptidase_M23; pfam01551 570417002996 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417002998 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 570417002999 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 570417003000 HIGH motif; other site 570417003001 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 570417003002 active site 570417003003 KMSKS motif; other site 570417003004 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 570417003005 tRNA binding surface [nucleotide binding]; other site 570417003006 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 570417003009 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 570417003011 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14187 570417003012 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 570417003013 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 570417003014 homodimer interface [polypeptide binding]; other site 570417003015 NADP binding site [chemical binding]; other site 570417003016 substrate binding site [chemical binding]; other site 570417003018 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003019 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. 570417003021 PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. 570417003022 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2.; PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 570417003023 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 570417003024 Flavoprotein; Region: Flavoprotein; cl08021 570417003027 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; cl11480 570417003028 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 570417003029 Domain of unknown function DUF21; Region: DUF21; pfam01595 570417003030 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 570417003031 Transporter associated domain; Region: CorC_HlyC; cl08393 570417003035 4 probable transmembrane helices predicted for WP0747 by TMHMM2.0 at aa 10-32, 65-87, 92-111 and 123-145 570417003036 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 570417003037 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 570417003038 inhibitor-cofactor binding pocket; inhibition site 570417003039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 570417003040 catalytic residue [active] 570417003043 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 570417003044 active site 570417003045 multimer interface [polypeptide binding]; other site 570417003047 PS00469 Nucleoside diphosphate kinases active site. 570417003048 2 probable transmembrane helices predicted for WP0750 by TMHMM2.0 at aa 56-78 and 83-105 570417003050 ferrochelatase; Reviewed; Region: hemH; PRK00035 570417003051 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 570417003052 C-terminal domain interface [polypeptide binding]; other site 570417003053 active site 570417003054 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 570417003055 active site 570417003056 N-terminal domain interface [polypeptide binding]; other site 570417003058 PS00534 Ferrochelatase signature. 570417003059 PS00018 EF-hand calcium-binding domain. 570417003060 4 probable transmembrane helices predicted for WP0752 by TMHMM2.0 at aa 105-124, 134-156, 195-212 and 227-249 570417003061 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 570417003062 Glutamate-cysteine ligase; Region: GshA; pfam08886 570417003064 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 570417003065 active site 570417003066 HslU subunit interaction site [polypeptide binding]; other site 570417003068 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 570417003069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 570417003070 Walker A motif; other site 570417003071 ATP binding site [chemical binding]; other site 570417003072 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417003073 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 570417003076 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003077 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 570417003079 1 probable transmembrane helix predicted for WP0756 by TMHMM2.0 at aa 7-29 570417003080 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 570417003081 substrate binding pocket [chemical binding]; other site 570417003082 chain length determination region; other site 570417003083 substrate-Mg2+ binding site; other site 570417003084 catalytic residues [active] 570417003085 aspartate-rich region 1; other site 570417003086 active site lid residues [active] 570417003087 aspartate-rich region 2; other site 570417003089 PS00723 Polyprenyl synthetases signature 1. 570417003090 Phosphopantetheine attachment site; Region: PP-binding; cl09936 570417003093 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 570417003094 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 570417003095 dimer interface [polypeptide binding]; other site 570417003096 active site 570417003098 PS00606 Beta-ketoacyl synthases active site. 570417003100 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 570417003101 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 570417003102 hinge; other site 570417003103 active site 570417003106 Thymidylate synthase complementing protein; Region: Thy1; cl03630 570417003109 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417003110 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417003111 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417003112 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 570417003113 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417003114 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417003133 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 570417003134 3 probable transmembrane helices predicted for WP0765 by TMHMM2.0 at aa 60-82, 481-503 and 510-532 570417003135 primosome assembly protein PriA; Validated; Region: PRK05580 570417003136 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 570417003137 ATP binding site [chemical binding]; other site 570417003138 putative Mg++ binding site [ion binding]; other site 570417003139 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417003143 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003145 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 570417003147 2 probable transmembrane helices predicted for WP0767 by TMHMM2.0 at aa 178-200 and 205-227 570417003148 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417003149 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417003153 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003154 1 probable transmembrane helix predicted for WP0768 by TMHMM2.0 at aa 377-399 570417003155 recombination protein RecR; Reviewed; Region: recR; PRK00076 570417003156 RecR protein; Region: RecR; pfam02132 570417003157 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 570417003158 putative active site [active] 570417003159 putative metal-binding site [ion binding]; other site 570417003160 tetramer interface [polypeptide binding]; other site 570417003164 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 570417003166 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 570417003167 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003168 heat shock protein 90; Provisional; Region: PRK05218 570417003169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 570417003170 PS00298 Heat shock hsp90 proteins family signature. 570417003173 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417003174 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417003178 2 probable transmembrane helices predicted for WP0774 by TMHMM2.0 at aa 487-509 and 513-532 570417003179 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003180 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417003181 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 570417003182 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417003183 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417003189 2 probable transmembrane helices predicted for WP0777 by TMHMM2.0 at aa 68-90 and 94-113 570417003190 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 570417003191 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 570417003192 substrate-cofactor binding pocket; other site 570417003193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 570417003194 catalytic residue [active] 570417003197 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 570417003198 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 570417003199 active site 570417003201 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 570417003202 elongation factor P; Validated; Region: PRK00529 570417003203 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 570417003204 RNA binding site [nucleotide binding]; other site 570417003205 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 570417003206 RNA binding site [nucleotide binding]; other site 570417003208 PS01275 Elongation factor P signature. 570417003211 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14592 570417003212 RimM N-terminal domain; Region: RimM; pfam01782 570417003213 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 570417003217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 570417003218 ATP binding site [chemical binding]; other site 570417003219 putative Mg++ binding site [ion binding]; other site 570417003220 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003221 5 probable transmembrane helices predicted for WP0782 by TMHMM2.0 at aa 236-258, 279-301, 1048-1070, 1077-1099 and 1103-1122 570417003222 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 570417003223 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 570417003224 inhibitor-cofactor binding pocket; inhibition site 570417003225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 570417003226 catalytic residue [active] 570417003229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 570417003230 dimer interface [polypeptide binding]; other site 570417003231 phosphorylation site [posttranslational modification] 570417003232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 570417003233 ATP binding site [chemical binding]; other site 570417003234 Mg2+ binding site [ion binding]; other site 570417003235 G-X-G motif; other site 570417003236 2 probable transmembrane helices predicted for WP0784 by TMHMM2.0 at aa 20-41 and 186-208 570417003239 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 570417003240 UGMP family protein; Validated; Region: PRK09604 570417003241 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 570417003244 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417003245 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417003246 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417003247 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417003248 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417003249 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417003250 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417003251 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417003252 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417003253 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417003254 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 570417003266 2 probable transmembrane helices predicted for WP0788 by TMHMM2.0 at aa 10-29 and 41-63 570417003267 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 570417003268 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 570417003269 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 570417003270 Walker A/P-loop; other site 570417003271 ATP binding site [chemical binding]; other site 570417003272 Q-loop/lid; other site 570417003273 ABC transporter signature motif; other site 570417003274 Walker B; other site 570417003275 D-loop; other site 570417003276 H-loop/switch region; other site 570417003278 5 probable transmembrane helices predicted for WP0789 by TMHMM2.0 at aa 25-47, 62-81, 133-155, 160-182 and 259-281 570417003279 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003281 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003282 PS00211 ABC transporters family signature. 570417003283 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 570417003284 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 570417003285 E3 interaction surface; other site 570417003286 lipoyl attachment site [posttranslational modification]; other site 570417003287 e3 binding domain; Region: E3_binding; pfam02817 570417003288 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 570417003293 2 probable transmembrane helices predicted for WP0794 by TMHMM2.0 at aa 225-247 and 259-281 570417003294 FtsH Extracellular; Region: FtsH_ext; pfam06480 570417003295 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 570417003296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 570417003297 Walker A motif; other site 570417003298 ATP binding site [chemical binding]; other site 570417003299 Walker B motif; other site 570417003300 arginine finger; other site 570417003301 Peptidase family M41; Region: Peptidase_M41; pfam01434 570417003305 PS00674 AAA-protein family signature. 570417003306 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003308 2 probable transmembrane helices predicted for WP0795 by TMHMM2.0 at aa 7-29 and 102-124 570417003309 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 570417003310 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 570417003311 Ligand Binding Site [chemical binding]; other site 570417003312 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003315 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 570417003316 ligand binding site [chemical binding]; other site 570417003318 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003319 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 570417003320 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 570417003321 Zn binding site [ion binding]; other site 570417003323 1 probable transmembrane helix predicted for WP0798 by TMHMM2.0 at aa 387-409 570417003324 rod shape-determining protein MreB; Provisional; Region: PRK13927 570417003325 Cell division protein FtsA; Region: FtsA; cl11496 570417003328 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003330 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 570417003331 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 570417003332 Ligand Binding Site [chemical binding]; other site 570417003336 2 probable transmembrane helices predicted for WP0801 by TMHMM2.0 at aa 346-368 and 383-405 570417003337 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 570417003338 dimer interface [polypeptide binding]; other site 570417003339 substrate binding site [chemical binding]; other site 570417003340 metal binding sites [ion binding]; metal-binding site 570417003342 SurA N-terminal domain; Region: SurA_N; pfam09312 570417003343 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 570417003344 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 570417003345 beta-alpha-beta structure motif; other site 570417003346 NAD binding pocket [chemical binding]; other site 570417003347 Iron coordination center [ion binding]; other site 570417003349 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 570417003351 transposase (pseudogene) 570417003354 2 probable transmembrane helices predicted for WP0808 by TMHMM2.0 at aa 109-131 and 136-158 570417003355 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 570417003356 conserved cys residue [active] 570417003358 LytB protein; Region: LYTB; cl00507 570417003359 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 570417003362 1 probable transmembrane helix predicted for WP0813 by TMHMM2.0 at aa 15-34 570417003363 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 570417003364 dimer interface [polypeptide binding]; other site 570417003365 ssDNA binding site [nucleotide binding]; other site 570417003366 tetramer (dimer of dimers) interface [polypeptide binding]; other site 570417003369 PS00735 Single-strand binding protein family signature 1. 570417003370 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 570417003371 dihydrodipicolinate synthase; Region: dapA; TIGR00674 570417003372 dimer interface [polypeptide binding]; other site 570417003373 active site 570417003374 catalytic residue [active] 570417003377 PS00665 Dihydrodipicolinate synthetase signature 1. 570417003378 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 570417003379 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 570417003380 NADP binding site [chemical binding]; other site 570417003381 dimer interface [polypeptide binding]; other site 570417003384 hypothetical protein (pseudogene) 570417003385 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 570417003387 1 probable transmembrane helix predicted for WP0819 by TMHMM2.0 at aa 13-35 570417003388 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 570417003390 7 probable transmembrane helices predicted for WP0820 by TMHMM2.0 at aa 28-50, 54-76, 89-111, 115-134, 141-163, 167-189 and 210-232 570417003391 Aminotransferase class-V; Region: Aminotran_5; pfam00266 570417003392 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 570417003393 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 570417003394 catalytic residue [active] 570417003397 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 570417003398 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 570417003399 1 probable transmembrane helix predicted for WP0823 by TMHMM2.0 at aa 20-42 570417003400 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003401 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 570417003402 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 570417003403 Walker A/P-loop; other site 570417003404 ATP binding site [chemical binding]; other site 570417003405 Q-loop/lid; other site 570417003406 ABC transporter signature motif; other site 570417003407 Walker B; other site 570417003408 D-loop; other site 570417003409 H-loop/switch region; other site 570417003411 PS00211 ABC transporters family signature. 570417003412 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003413 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 570417003416 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 570417003417 Zn2+ binding site [ion binding]; other site 570417003418 Mg2+ binding site [ion binding]; other site 570417003419 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 570417003420 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003424 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 570417003425 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 570417003426 catalytic motif [active] 570417003427 Zn binding site [ion binding]; other site 570417003428 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 570417003431 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 570417003433 2 probable transmembrane helices predicted for WP0828 by TMHMM2.0 at aa 21-43 and 47-69 570417003434 Pseudouridine synthase [Translation, ribosomal structure and biogenesis]; Region: TruB; COG0130 570417003435 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 570417003436 RNA binding site [nucleotide binding]; other site 570417003437 active site 570417003440 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 570417003441 16S/18S rRNA binding site [nucleotide binding]; other site 570417003442 S13e-L30e interaction site [polypeptide binding]; other site 570417003443 25S rRNA binding site [nucleotide binding]; other site 570417003446 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 570417003447 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 570417003448 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 570417003449 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 570417003450 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 570417003451 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 570417003452 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 570417003453 putative nucleic acid binding region [nucleotide binding]; other site 570417003454 G-X-X-G motif; other site 570417003455 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 570417003456 RNA binding site [nucleotide binding]; other site 570417003458 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003465 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 570417003466 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 570417003467 substrate binding site [chemical binding]; other site 570417003468 hexamer interface [polypeptide binding]; other site 570417003469 metal binding site [ion binding]; metal-binding site 570417003472 PS01086 Ribulose-phosphate 3-epimerase family signature 2. 570417003473 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 570417003474 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 570417003475 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 570417003476 amidase catalytic site [active] 570417003477 Zn binding residues [ion binding]; other site 570417003478 substrate binding site [chemical binding]; other site 570417003480 Endoribonuclease XendoU; Region: XendoU; pfam09412 570417003481 1 probable transmembrane helix predicted for WP0834 by TMHMM2.0 at aa 7-22 570417003482 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 570417003483 substrate binding site [chemical binding]; other site 570417003484 hinge regions; other site 570417003485 ADP binding site [chemical binding]; other site 570417003486 catalytic site [active] 570417003488 PS00111 Phosphoglycerate kinase signature. 570417003489 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 570417003490 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 570417003491 dimer interface [polypeptide binding]; other site 570417003492 glycine-pyridoxal phosphate binding site [chemical binding]; other site 570417003493 active site 570417003494 folate binding site [chemical binding]; other site 570417003497 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 570417003498 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 570417003500 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 570417003501 putative substrate translocation pore; other site 570417003502 12 probable transmembrane helices predicted for WP0837 by TMHMM2.0 at aa 5-23, 43-65, 72-94, 98-120, 132-154, 159-181, 202-224, 244-266, 273-292, 297-319, 326-348 and 376-398 570417003504 1 probable transmembrane helix predicted for WP0838 by TMHMM2.0 at aa 21-40 570417003505 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 570417003506 4 probable transmembrane helices predicted for WP0840 by TMHMM2.0 at aa 2-19, 29-48, 55-77 and 82-104 570417003508 aspartate aminotransferase; Provisional; Region: PRK05764 570417003509 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 570417003510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 570417003511 homodimer interface [polypeptide binding]; other site 570417003512 catalytic residue [active] 570417003514 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003515 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 570417003516 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003517 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 570417003518 substrate binding site [chemical binding]; other site 570417003519 active site 570417003522 PS00907 Uroporphyrinogen decarboxylase signature 2. 570417003523 PS00906 Uroporphyrinogen decarboxylase signature 1. 570417003524 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 570417003525 Transporter associated domain; Region: CorC_HlyC; cl08393 570417003528 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417003530 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 570417003531 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 570417003532 putative NAD(P) binding site [chemical binding]; other site 570417003533 active site 570417003539 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 570417003540 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 570417003541 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 570417003542 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 570417003547 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 570417003548 nucleotide binding site/active site [active] 570417003549 HIT family signature motif; other site 570417003550 catalytic residue [active] 570417003552 PS00892 HIT family signature. 570417003553 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 570417003554 3 probable transmembrane helices predicted for WP0852 by TMHMM2.0 at aa 7-29, 59-81 and 88-110 570417003556 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 570417003558 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003560 PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. 570417003561 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 570417003564 malate dehydrogenase; Reviewed; Region: PRK06223 570417003565 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 570417003566 NAD(P) binding site [chemical binding]; other site 570417003567 dimer interface [polypeptide binding]; other site 570417003568 tetramer (dimer of dimers) interface [polypeptide binding]; other site 570417003569 substrate binding site [chemical binding]; other site 570417003574 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 570417003575 active site 570417003578 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 570417003579 putative active site [active] 570417003580 Ap4A binding site [chemical binding]; other site 570417003581 nudix motif; other site 570417003582 putative metal binding site [ion binding]; other site 570417003584 PS00893 mutT domain signature. 570417003585 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417003586 active site 570417003587 Domain of unknown function DUF143; Region: DUF143; cl00519 570417003590 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 570417003591 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 570417003592 active site 570417003593 HIGH motif; other site 570417003594 dimer interface [polypeptide binding]; other site 570417003595 KMSKS motif; other site 570417003596 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 570417003597 RNA binding surface [nucleotide binding]; other site 570417003601 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417003602 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417003603 2 probable transmembrane helices predicted for WP0862 by TMHMM2.0 at aa 173-195 and 200-222 570417003607 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 570417003608 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 570417003610 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003611 2 probable transmembrane helices predicted for WP0866 by TMHMM2.0 at aa 31-53 and 60-82 570417003612 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 570417003613 active site 570417003614 DNA binding site [nucleotide binding] 570417003617 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 570417003618 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 570417003619 Mg++ binding site [ion binding]; other site 570417003620 putative catalytic motif [active] 570417003621 putative substrate binding site [chemical binding]; other site 570417003622 10 probable transmembrane helices predicted for WP0869 by TMHMM2.0 at aa 7-26, 51-70, 77-93, 113-135, 148-167, 177-194, 199-221, 225-246, 251-273 and 306-325 570417003625 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 570417003626 RNA/DNA hybrid binding site [nucleotide binding]; other site 570417003627 active site 570417003629 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 570417003630 VirB7 interaction site; other site 570417003632 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 570417003633 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 570417003634 dimerization interface [polypeptide binding]; other site 570417003635 putative ATP binding site [chemical binding]; other site 570417003639 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 570417003640 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 570417003641 ATP binding site [chemical binding]; other site 570417003642 active site 570417003643 substrate binding site [chemical binding]; other site 570417003646 PS01058 SAICAR synthetase signature 2. 570417003647 PS01057 SAICAR synthetase signature 1. 570417003648 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 570417003651 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 570417003654 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 570417003655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 570417003656 dimer interface [polypeptide binding]; other site 570417003657 conserved gate region; other site 570417003658 putative PBP binding loops; other site 570417003659 ABC-ATPase subunit interface; other site 570417003661 6 probable transmembrane helices predicted for WP0879 by TMHMM2.0 at aa 31-53, 201-223, 243-265, 269-288, 333-355 and 381-403 570417003662 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003664 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 570417003665 putative active site [active] 570417003666 catalytic triad [active] 570417003667 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 570417003668 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 570417003669 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 570417003672 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 570417003673 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 570417003674 DNA binding site [nucleotide binding] 570417003675 catalytic residue [active] 570417003676 H2TH interface [polypeptide binding]; other site 570417003677 putative catalytic residues [active] 570417003678 turnover-facilitating residue; other site 570417003679 intercalation triad [nucleotide binding]; other site 570417003680 8OG recognition residue [nucleotide binding]; other site 570417003681 putative reading head residues; other site 570417003682 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 570417003683 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 570417003688 transposase (pseudogene);Disrupted by IS insertion. 570417003690 transposase (pseudogene) 570417003692 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 570417003694 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417003696 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 570417003697 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 570417003698 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 570417003700 GTP-binding protein Der; Reviewed; Region: PRK00093 570417003701 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 570417003702 G1 box; other site 570417003703 GTP/Mg2+ binding site [chemical binding]; other site 570417003704 Switch I region; other site 570417003705 G2 box; other site 570417003706 Switch II region; other site 570417003707 G3 box; other site 570417003708 G4 box; other site 570417003709 G5 box; other site 570417003710 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 570417003711 G1 box; other site 570417003712 GTP/Mg2+ binding site [chemical binding]; other site 570417003713 Switch I region; other site 570417003714 G2 box; other site 570417003715 G3 box; other site 570417003716 Switch II region; other site 570417003717 G4 box; other site 570417003718 G5 box; other site 570417003722 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003726 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003727 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 570417003728 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 570417003730 3 probable transmembrane helices predicted for WP0894 by TMHMM2.0 at aa 10-32, 61-83 and 125-147 570417003731 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 570417003732 Phosphotransferase enzyme family; Region: APH; pfam01636 570417003733 putative active site [active] 570417003734 putative substrate binding site [chemical binding]; other site 570417003735 ATP binding site [chemical binding]; other site 570417003737 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 570417003738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417003739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417003740 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 570417003744 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 570417003747 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 570417003748 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 570417003749 active site 570417003750 homodimer interface [polypeptide binding]; other site 570417003753 glutathione synthetase; Provisional; Region: PRK05246 570417003754 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 570417003755 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 570417003760 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 570417003761 catalytic triad [active] 570417003764 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 570417003765 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417003766 Walker A/P-loop; other site 570417003767 ATP binding site [chemical binding]; other site 570417003768 Q-loop/lid; other site 570417003769 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417003770 ABC transporter signature motif; other site 570417003771 Walker B; other site 570417003772 D-loop; other site 570417003773 H-loop/switch region; other site 570417003775 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003776 aspartate kinase; Reviewed; Region: PRK06635 570417003777 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 570417003778 putative nucleotide binding site [chemical binding]; other site 570417003779 putative catalytic residues [active] 570417003780 putative Mg ion binding site [ion binding]; other site 570417003781 putative aspartate binding site [chemical binding]; other site 570417003782 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 570417003784 PS00044 Bacterial regulatory proteins, lysR family signature. 570417003786 PS00324 Aspartokinase signature. 570417003787 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 570417003788 putative cation:proton antiport protein; Provisional; Region: PRK10669 570417003789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417003791 12 probable transmembrane helices predicted for WP0903 by TMHMM2.0 at aa 4-26, 33-51, 61-83, 88-110, 114-136, 149-171, 186-205, 217-236, 274-293, 300-322, 326-348 and 361-383 570417003794 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 570417003795 putative catalytic residue [active] 570417003797 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 570417003798 thymidylate kinase; Validated; Region: tmk; PRK00698 570417003799 TMP-binding site; other site 570417003800 ATP-binding site [chemical binding]; other site 570417003803 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003804 PS01331 Thymidylate kinase signature. 570417003805 Competence protein; Region: Competence; cl00471 570417003806 11 probable transmembrane helices predicted for WP0906 by TMHMM2.0 at aa 17-35, 40-62, 252-274, 294-316, 336-358, 362-384, 391-412, 427-449, 462-481, 485-504 and 511-533 570417003809 FemAB family; Region: FemAB; cl11444 570417003810 4 probable transmembrane helices predicted for WP0907 by TMHMM2.0 at aa 42-64, 79-101, 184-206 and 216-235 570417003811 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 570417003812 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 570417003813 RNA binding surface [nucleotide binding]; other site 570417003814 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 570417003815 active site 570417003819 PS01129 Rlu family of pseudouridine synthase signature. 570417003820 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 570417003822 3 probable transmembrane helices predicted for WP0909 by TMHMM2.0 at aa 33-50, 54-73 and 94-113 570417003823 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417003825 Putative transposas (fragment) 570417003826 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003827 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 570417003828 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 570417003829 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 570417003830 Interleukin-3; Region: IL3; pfam02059 570417003831 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 570417003832 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 570417003833 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 570417003834 IMP binding site; other site 570417003835 dimer interface [polypeptide binding]; other site 570417003836 interdomain contacts; other site 570417003837 partial ornithine binding site; other site 570417003841 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 570417003845 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 570417003847 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003848 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 570417003849 classical (c) SDRs; Region: SDR_c; cd05233 570417003850 NAD(P) binding site [chemical binding]; other site 570417003851 active site 570417003854 PS00061 Short-chain dehydrogenases/reductases family signature. 570417003855 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 570417003858 6 probable transmembrane helices predicted for WP0915 by TMHMM2.0 at aa 28-50, 95-117, 138-160, 170-189, 201-223 and 233-255 570417003859 TrbC/VIRB2 family; Region: TrbC; cl01583 570417003860 3 probable transmembrane helices predicted for WP0916 by TMHMM2.0 at aa 5-27, 37-56 and 63-85 570417003861 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417003863 amidophosphoribosyltransferase; Provisional; Region: PRK09123 570417003864 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 570417003865 active site 570417003866 tetramer interface [polypeptide binding]; other site 570417003867 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 570417003870 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 570417003872 PS00443 Glutamine amidotransferases class-II active site. 570417003873 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 570417003874 diiron binding motif [ion binding]; other site 570417003876 1 probable transmembrane helix predicted for WP0921 by TMHMM2.0 at aa 72-94 570417003878 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 570417003879 Fe-S cluster binding site [ion binding]; other site 570417003880 active site 570417003883 1 probable transmembrane helix predicted for WP0922 by TMHMM2.0 at aa 172-191 570417003884 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 570417003885 active site 570417003886 catalytic residues [active] 570417003887 metal binding site [ion binding]; metal-binding site 570417003890 cell division protein FtsA; Region: ftsA; TIGR01174 570417003891 Cell division protein FtsA; Region: FtsA; cl11496 570417003892 Cell division protein FtsA; Region: FtsA; cl11496 570417003895 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003896 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417003898 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 570417003899 active site 570417003902 metabolite-proton symporter; Region: 2A0106; TIGR00883 570417003903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 570417003904 putative substrate translocation pore; other site 570417003906 12 probable transmembrane helices predicted for WP0926 by TMHMM2.0 at aa 7-29, 49-71, 78-100, 104-123, 143-165, 175-197, 226-248, 258-280, 292-311, 316-338, 351-373 and 377-399 570417003908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 570417003909 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 570417003911 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417003913 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 570417003915 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 570417003916 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 570417003917 5S rRNA interface [nucleotide binding]; other site 570417003918 CTC domain interface [polypeptide binding]; other site 570417003919 L16 interface [polypeptide binding]; other site 570417003922 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 570417003923 putative active site [active] 570417003924 catalytic residue [active] 570417003927 PS01196 Peptidyl-tRNA hydrolase signature 2. 570417003928 PS00214 Cytosolic fatty-acid binding proteins signature. 570417003929 recombinase A; Provisional; Region: recA; PRK09354 570417003930 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 570417003931 hexamer interface [polypeptide binding]; other site 570417003932 Walker A motif; other site 570417003933 ATP binding site [chemical binding]; other site 570417003934 Walker B motif; other site 570417003937 PS00321 recA signature. 570417003938 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003939 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 570417003940 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 570417003941 dimerization interface 3.5A [polypeptide binding]; other site 570417003942 active site 570417003946 DNA polymerase III subunit beta; Validated; Region: PRK05643 570417003947 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 570417003948 putative DNA binding surface [nucleotide binding]; other site 570417003949 dimer interface [polypeptide binding]; other site 570417003950 beta-clamp/clamp loader binding surface; other site 570417003951 beta-clamp/translesion DNA polymerase binding surface; other site 570417003956 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 570417003957 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 570417003958 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 570417003959 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 570417003962 Surface antigen; Region: Surface_Ag_2; cl01155 570417003965 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 570417003968 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14964 570417003969 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417003970 Walker A motif; other site 570417003971 ATP binding site [chemical binding]; other site 570417003972 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417003973 Walker B motif; other site 570417003974 arginine finger; other site 570417003975 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 570417003976 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 570417003979 PS00017 ATP/GTP-binding site motif A (P-loop). 570417003980 Wolbachia palindromic element (WPE) domain; Region: WPE_wolbac; TIGR02697 570417003981 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 570417003982 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 570417003983 C-terminal domain interface [polypeptide binding]; other site 570417003984 GSH binding site (G-site) [chemical binding]; other site 570417003985 dimer interface [polypeptide binding]; other site 570417003986 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 570417003987 N-terminal domain interface [polypeptide binding]; other site 570417003988 dimer interface [polypeptide binding]; other site 570417003989 substrate binding pocket (H-site) [chemical binding]; other site 570417003992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 570417003994 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 570417003995 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 570417003996 catalytic residues [active] 570417003997 1 probable transmembrane helix predicted for WP0944 by TMHMM2.0 at aa 10-32 570417003998 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 570417003999 putative coenzyme Q binding site [chemical binding]; other site 570417004001 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; cl01074 570417004003 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 570417004004 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 570417004007 PS01011 Folylpolyglutamate synthase signature 1. 570417004008 PS01012 Folylpolyglutamate synthase signature 2. 570417004009 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004010 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 570417004011 2 probable transmembrane helices predicted for WP0948 by TMHMM2.0 at aa 29-51 and 61-78 570417004012 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004013 4 probable transmembrane helices predicted for WP0949 by TMHMM2.0 at aa 21-40, 45-67, 88-110 and 115-137 570417004014 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 570417004015 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 570417004017 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417004019 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 570417004020 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 570417004021 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 570417004022 [2Fe-2S] cluster binding site [ion binding]; other site 570417004025 PS00199 Rieske iron-sulfur protein signature 1. 570417004027 1 probable transmembrane helix predicted for WP0952 by TMHMM2.0 at aa 34-56 570417004028 DNA gyrase subunit A; Validated; Region: PRK05560 570417004029 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 570417004030 CAP-like domain; other site 570417004031 active site 570417004032 primary dimer interface [polypeptide binding]; other site 570417004033 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 570417004034 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 570417004035 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 570417004036 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 570417004037 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 570417004038 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 570417004047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 570417004048 binding surface 570417004049 TPR motif; other site 570417004053 1 probable transmembrane helix predicted for WP0954 by TMHMM2.0 at aa 15-37 570417004054 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 570417004056 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 570417004058 5 probable transmembrane helices predicted for WP0956 by TMHMM2.0 at aa 10-32, 55-77, 81-103, 116-138 and 148-170 570417004059 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004060 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 570417004061 putative FMN binding site [chemical binding]; other site 570417004063 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 570417004064 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 570417004065 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 570417004066 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 570417004069 PS01326 Diaminopimelate epimerase signature. 570417004071 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004072 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 570417004073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417004074 CoA-ligase; Region: Ligase_CoA; pfam00549 570417004077 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 570417004078 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 570417004080 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 570417004081 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 570417004082 CoA-ligase; Region: Ligase_CoA; pfam00549 570417004085 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 570417004088 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 570417004091 conserved hypothetical protein (pseudogene);does not contain any ANK repeats, similar to N-terminal of the wMel ANK gene (also tmp0653 but less similar) 570417004092 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 570417004094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 570417004095 dimer interface [polypeptide binding]; other site 570417004096 phosphorylation site [posttranslational modification] 570417004097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 570417004098 ATP binding site [chemical binding]; other site 570417004099 Mg2+ binding site [ion binding]; other site 570417004100 G-X-G motif; other site 570417004101 Response regulator receiver domain; Region: Response_reg; pfam00072 570417004102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 570417004103 active site 570417004104 phosphorylation site [posttranslational modification] 570417004105 intermolecular recognition site; other site 570417004106 dimerization interface [polypeptide binding]; other site 570417004107 3 probable transmembrane helices predicted for WP0966 by TMHMM2.0 at aa 21-43, 53-72 and 280-299 570417004111 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 570417004112 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417004114 PS00017 ATP/GTP-binding site motif A (P-loop). 570417004115 ParB-like partition proteins; Region: parB_part; TIGR00180 570417004116 ParB-like nuclease domain; Region: ParBc; cl02129 570417004119 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 570417004120 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 570417004121 substrate binding site; other site 570417004122 dimer interface; other site 570417004123 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 570417004124 homotrimer interaction site [polypeptide binding]; other site 570417004125 zinc binding site [ion binding]; other site 570417004126 CDP-binding sites; other site 570417004131 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 570417004132 1 probable transmembrane helix predicted for WP0970 by TMHMM2.0 at aa 7-29 570417004133 Putative membrane protein (pseudogene);8 probable TM helices predicted; Disrupted by IS insertion 570417004134 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 570417004135 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 570417004136 putative active site [active] 570417004137 putative NTP binding site [chemical binding]; other site 570417004138 putative nucleic acid binding site [nucleotide binding]; other site 570417004139 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 570417004140 PS00962 Ribosomal protein S2 signature 1. 570417004141 ERp29 and ERp38, C-terminal domain; composed of the protein disulfide isomerase (PDI)-like proteins ERp29 and ERp38. ERp29 (also called ERp28) is a ubiquitous endoplasmic reticulum (ER)-resident protein expressed in high levels in secretory cells. It...; Region: ERp29c; cl02782 570417004142 RNA-directed DNA polymerase (reverse transcriptase) (pseudogene);Disrupted by IS insertion 570417004143 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 570417004144 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 570417004145 putative active site [active] 570417004146 putative NTP binding site [chemical binding]; other site 570417004147 putative nucleic acid binding site [nucleotide binding]; other site 570417004148 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 570417004150 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417004152 PS00017 ATP/GTP-binding site motif A (P-loop). 570417004153 1 probable transmembrane helix predicted for WP0979 by TMHMM2.0 at aa 16-33 570417004154 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 570417004155 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 570417004156 DNA binding site [nucleotide binding] 570417004157 Int/Topo IB signature motif; other site 570417004158 active site 570417004162 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 570417004163 putative acyl-acceptor binding pocket; other site 570417004164 PS00678 Trp-Asp (WD) repeats signature. 570417004165 3 probable transmembrane helices predicted for WP0981 by TMHMM2.0 at aa 5-27, 31-53 and 164-186 570417004167 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 570417004170 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 570417004171 dimer interface [polypeptide binding]; other site 570417004172 Citrate synthase; Region: Citrate_synt; pfam00285 570417004173 active site 570417004174 citrylCoA binding site [chemical binding]; other site 570417004175 NADH binding [chemical binding]; other site 570417004176 cationic pore residues; other site 570417004177 oxalacetate/citrate binding site [chemical binding]; other site 570417004178 coenzyme A binding site [chemical binding]; other site 570417004179 catalytic triad [active] 570417004182 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004183 PS00480 Citrate synthase signature. 570417004184 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 570417004185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 570417004186 Walker A motif; other site 570417004187 ATP binding site [chemical binding]; other site 570417004188 Walker B motif; other site 570417004189 arginine finger; other site 570417004190 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 570417004195 PS00017 ATP/GTP-binding site motif A (P-loop). 570417004197 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 570417004198 RuvA N terminal domain; Region: RuvA_N; pfam01330 570417004199 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 570417004202 Cytochrome c; Region: Cytochrom_C; cl11414 570417004203 1 probable transmembrane helix predicted for WP0989 by TMHMM2.0 at aa 7-29 570417004204 PS00017 ATP/GTP-binding site motif A (P-loop). 570417004206 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 570417004207 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 570417004209 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 570417004210 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417004212 PS00017 ATP/GTP-binding site motif A (P-loop). 570417004213 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 570417004214 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 570417004215 5 probable transmembrane helices predicted for WP0993 by TMHMM2.0 at aa 4-22, 29-46, 50-72, 85-107 and 137-159 570417004217 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 570417004218 3 probable transmembrane helices predicted for WP0994 by TMHMM2.0 at aa 4-26, 31-53 and 63-85 570417004220 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 570417004221 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 570417004222 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 570417004223 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 570417004225 16 probable transmembrane helices predicted for WP0995 by TMHMM2.0 at aa 4-22, 27-49, 75-97, 106-123, 127-149, 162-184, 215-237, 246-265, 280-297, 304-326, 330-352, 372-394, 409-431, 452-474, 494-516 and 592-614 570417004228 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004229 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004231 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 570417004232 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 570417004234 14 probable transmembrane helices predicted for WP0996 by TMHMM2.0 at aa 4-22, 27-49, 69-91, 104-121, 125-147, 159-181, 201-223, 236-255, 265-287, 294-311, 321-343, 355-377, 397-419 and 440-462 570417004235 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004237 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 570417004238 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 570417004240 14 probable transmembrane helices predicted for WP0997 by TMHMM2.0 at aa 4-26, 33-51, 66-88, 95-112, 117-136, 148-170, 190-212, 224-246, 259-281, 288-310, 315-334, 355-377, 392-411 and 431-450 570417004242 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004243 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 570417004244 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 570417004245 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 570417004248 PS00017 ATP/GTP-binding site motif A (P-loop). 570417004250 1 probable transmembrane helix predicted for WP0999 by TMHMM2.0 at aa 5-27 570417004251 CcmE; Region: CcmE; cl00994 570417004253 1 probable transmembrane helix predicted for WP1000 by TMHMM2.0 at aa 7-29 570417004254 MgtE intracellular N domain; Region: MgtE_N; cl15244 570417004255 Domain of unknown function (DUF3559); Region: DUF3559; pfam12082 570417004256 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 570417004257 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 570417004258 SLBB domain; Region: SLBB; pfam10531 570417004259 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 570417004262 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004263 PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. 570417004264 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 570417004265 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 570417004266 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 570417004270 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 570417004271 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 570417004272 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 570417004273 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 570417004274 active site 570417004275 dimer interface [polypeptide binding]; other site 570417004276 motif 1; other site 570417004277 motif 2; other site 570417004278 motif 3; other site 570417004279 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 570417004280 anticodon binding site; other site 570417004283 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 570417004285 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 570417004287 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 570417004288 4Fe-4S binding domain; Region: Fer4; cl02805 570417004289 4Fe-4S binding domain; Region: Fer4; cl02805 570417004292 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 570417004294 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 570417004295 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 570417004296 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 570417004297 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 570417004298 G1 box; other site 570417004299 GTP/Mg2+ binding site [chemical binding]; other site 570417004300 Switch I region; other site 570417004301 G2 box; other site 570417004302 Switch II region; other site 570417004303 G3 box; other site 570417004304 G4 box; other site 570417004305 G5 box; other site 570417004306 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 570417004311 PS00017 ATP/GTP-binding site motif A (P-loop). 570417004312 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 570417004313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417004314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417004317 1 probable transmembrane helix predicted for WP1010 by TMHMM2.0 at aa 5-24 570417004319 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417004321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 570417004322 Terminase-like family; Region: Terminase_6; pfam03237 570417004323 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 570417004326 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417004327 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417004328 LrgB-like family; Region: LrgB; cl00596 570417004332 2 probable transmembrane helices predicted for WP1014 by TMHMM2.0 at aa 216-238 and 248-270 570417004333 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 570417004334 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 570417004335 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 570417004336 catalytic residue [active] 570417004339 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 570417004340 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 570417004342 10 probable transmembrane helices predicted for WP1016 by TMHMM2.0 at aa 7-28, 38-60, 67-89, 99-121, 134-149, 154-173, 178-197, 265-287, 299-321 and 331-353 570417004344 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12662 570417004345 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 570417004346 13 probable transmembrane helices predicted for WP1017 by TMHMM2.0 at aa 4-21, 28-47, 72-94, 107-126, 130-151, 163-185, 205-227, 240-262, 268-290, 311-333, 371-393, 406-428 and 448-470 570417004348 NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; cl01534 570417004350 mce related protein; Region: MCE; cl15431 570417004351 1 probable transmembrane helix predicted for WP1019 by TMHMM2.0 at aa 10-32 570417004353 transposase (fragment) 570417004354 putative transposase (pseudogene) 570417004355 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417004357 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 570417004358 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 570417004359 dimer interface [polypeptide binding]; other site 570417004360 active site 570417004361 CoA binding pocket [chemical binding]; other site 570417004365 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 570417004368 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 570417004371 Domain of unknown function DUF140; Region: DUF140; cl00510 570417004374 6 probable transmembrane helices predicted for WP1028 by TMHMM2.0 at aa 20-39, 54-76, 89-111, 152-174, 195-217 and 232-254 570417004375 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004376 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 570417004377 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417004378 Walker A/P-loop; other site 570417004379 ATP binding site [chemical binding]; other site 570417004380 Q-loop/lid; other site 570417004381 ABC transporter signature motif; other site 570417004382 Walker B; other site 570417004383 D-loop; other site 570417004384 H-loop/switch region; other site 570417004386 PS00017 ATP/GTP-binding site motif A (P-loop). 570417004387 PS00211 ABC transporters family signature. 570417004388 transposase (pseudogene);Disrupted by IS insertion 570417004390 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417004392 signal recognition particle protein; Provisional; Region: PRK10867 570417004393 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 570417004394 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 570417004395 P loop; other site 570417004396 GTP binding site [chemical binding]; other site 570417004397 Signal peptide binding domain; Region: SRP_SPB; pfam02978 570417004401 PS00017 ATP/GTP-binding site motif A (P-loop). 570417004403 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12664 570417004404 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 570417004405 14 probable transmembrane helices predicted for WP1033 by TMHMM2.0 at aa 7-29, 44-66, 87-109, 114-136, 141-160, 200-218, 225-244, 250-272, 293-315, 340-359, 372-394, 409-431, 443-460 and 496-518 570417004407 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004408 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 570417004409 Wolbachia palindromic element (WPE) domain; Region: WPE_wolbac; TIGR02697 570417004410 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 570417004411 FAD binding pocket [chemical binding]; other site 570417004412 conserved FAD binding motif [chemical binding]; other site 570417004413 phosphate binding motif [ion binding]; other site 570417004414 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 570417004417 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 570417004418 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 570417004420 1 probable transmembrane helix predicted for WP1036 by TMHMM2.0 at aa 4-26 570417004421 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 570417004422 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 570417004423 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 570417004424 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 570417004425 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 570417004426 Surface antigen; Region: Bac_surface_Ag; cl03097 570417004433 1 probable transmembrane helix predicted for WP1037 by TMHMM2.0 at aa 5-22 570417004434 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 570417004435 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 570417004436 active site 570417004437 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 570417004438 protein binding site [polypeptide binding]; other site 570417004439 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 570417004440 putative substrate binding region [chemical binding]; other site 570417004443 4 probable transmembrane helices predicted for WP1038 by TMHMM2.0 at aa 7-29, 113-135, 296-318 and 346-365 570417004444 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 570417004446 Cell division protein ZapA; Region: ZapA; cl01146 570417004447 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 570417004448 IHF - DNA interface [nucleotide binding]; other site 570417004449 IHF dimer interface [polypeptide binding]; other site 570417004451 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 570417004452 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 570417004453 RNA binding site [nucleotide binding]; other site 570417004454 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 570417004455 RNA binding site [nucleotide binding]; other site 570417004456 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 570417004457 RNA binding site [nucleotide binding]; other site 570417004458 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 570417004459 RNA binding site [nucleotide binding]; other site 570417004460 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 570417004461 RNA binding site [nucleotide binding]; other site 570417004468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 570417004471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 570417004472 Terminase-like family; Region: Terminase_6; pfam03237 570417004473 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 570417004476 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417004478 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 570417004479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 570417004480 Walker A motif; other site 570417004481 ATP binding site [chemical binding]; other site 570417004482 Walker B motif; other site 570417004483 arginine finger; other site 570417004485 PS00674 AAA-protein family signature. 570417004486 PS00017 ATP/GTP-binding site motif A (P-loop). 570417004487 2 probable transmembrane helices predicted for WP1049 by TMHMM2.0 at aa 13-35 and 45-67 570417004488 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 570417004489 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 570417004490 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 570417004491 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 570417004496 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 570417004497 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 570417004498 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 570417004499 protein binding site [polypeptide binding]; other site 570417004503 1 probable transmembrane helix predicted for WP1052 by TMHMM2.0 at aa 5-22 570417004504 HflC protein; Region: hflC; TIGR01932 570417004505 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 570417004508 1 probable transmembrane helix predicted for WP1053 by TMHMM2.0 at aa 7-26 570417004509 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 570417004510 HflK protein; Region: hflK; TIGR01933 570417004513 1 probable transmembrane helix predicted for WP1054 by TMHMM2.0 at aa 45-64 570417004514 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 570417004515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 570417004516 ATP binding site [chemical binding]; other site 570417004517 Mg2+ binding site [ion binding]; other site 570417004518 G-X-G motif; other site 570417004519 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 570417004520 ATP binding site [chemical binding]; other site 570417004521 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 570417004525 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 570417004526 AIR carboxylase; Region: AIRC; cl00310 570417004529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 570417004530 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 570417004531 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 570417004534 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 570417004535 3 probable transmembrane helices predicted for WP1060 by TMHMM2.0 at aa 4-22, 31-53 and 58-80 570417004536 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 570417004537 3 probable transmembrane helices predicted for WP1061 by TMHMM2.0 at aa 2-24, 34-51 and 63-85 570417004538 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 570417004539 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 570417004540 5 probable transmembrane helices predicted for WP1062 by TMHMM2.0 at aa 4-21, 26-48, 53-75, 82-104 and 151-168 570417004541 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004542 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 570417004544 4 probable transmembrane helices predicted for WP1063 by TMHMM2.0 at aa 5-27, 37-54, 67-89 and 109-131 570417004545 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 570417004546 3 probable transmembrane helices predicted for WP1064 by TMHMM2.0 at aa 4-21, 33-50 and 70-92 570417004548 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 570417004549 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 570417004550 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 570417004551 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 570417004552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 570417004553 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 570417004554 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 570417004555 DNA binding residues [nucleotide binding] 570417004559 PS00715 Sigma-70 factors family signature 1. 570417004562 PS00716 Sigma-70 factors family signature 2. 570417004563 lipolytic enzyme, gdsl family (pseudogene) 570417004564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 570417004565 1 probable transmembrane helix predicted for WP1067 by TMHMM2.0 at aa 26-44 570417004566 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 570417004567 Iron-sulfur protein interface; other site 570417004568 proximal quinone binding site [chemical binding]; other site 570417004569 SdhD (CybS) interface [polypeptide binding]; other site 570417004570 proximal heme binding site [chemical binding]; other site 570417004572 PS01000 Succinate dehydrogenase cytochrome b subunit signature 1. 570417004573 3 probable transmembrane helices predicted for WP1068 by TMHMM2.0 at aa 23-45, 58-80 and 100-122 570417004574 PS01001 Succinate dehydrogenase cytochrome b subunit signature 2. 570417004575 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 570417004576 putative SdhC subunit interface [polypeptide binding]; other site 570417004577 putative proximal heme binding site [chemical binding]; other site 570417004578 putative Iron-sulfur protein interface [polypeptide binding]; other site 570417004579 putative proximal quinone binding site; other site 570417004581 3 probable transmembrane helices predicted for WP1069 by TMHMM2.0 at aa 16-38, 58-80 and 87-109 570417004582 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 570417004583 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 570417004584 Substrate binding site; other site 570417004585 Cupin domain; Region: Cupin_2; cl09118 570417004586 PS00430 TonB-dependent receptor proteins signature 1. 570417004590 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 570417004591 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 570417004592 FtsX-like permease family; Region: FtsX; pfam02687 570417004594 4 probable transmembrane helices predicted for WP1072 by TMHMM2.0 at aa 21-43, 267-289, 310-332 and 366-388 570417004596 1 probable transmembrane helix predicted for WP1073 by TMHMM2.0 at aa 7-29 570417004597 conserved hypothetical protein (pseudogene) 570417004598 ATP synthase; Region: ATP-synt; cl00365 570417004599 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 570417004602 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 570417004603 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 570417004605 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 570417004606 DNA-binding site [nucleotide binding]; DNA binding site 570417004607 RNA-binding motif; other site 570417004609 PS00352 'Cold-shock' DNA-binding domain signature. 570417004610 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 570417004611 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 570417004612 ATP binding site [chemical binding]; other site 570417004613 Mg++ binding site [ion binding]; other site 570417004614 motif III; other site 570417004615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 570417004616 nucleotide binding region [chemical binding]; other site 570417004617 ATP-binding site [chemical binding]; other site 570417004619 PS00017 ATP/GTP-binding site motif A (P-loop). 570417004621 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 570417004622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 570417004623 Walker A motif; other site 570417004624 ATP binding site [chemical binding]; other site 570417004625 Walker B motif; other site 570417004626 arginine finger; other site 570417004627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 570417004628 Walker A motif; other site 570417004629 ATP binding site [chemical binding]; other site 570417004630 Walker B motif; other site 570417004631 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 570417004633 PS00017 ATP/GTP-binding site motif A (P-loop). 570417004634 PS00870 Chaperonins clpA/B signature 1. 570417004637 PS00017 ATP/GTP-binding site motif A (P-loop). 570417004639 4 probable transmembrane helices predicted for WP1080 by TMHMM2.0 at aa 121-138, 158-180, 201-220 and 230-252 570417004640 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 570417004641 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 570417004642 putative active site; other site 570417004643 catalytic residue [active] 570417004645 1 probable transmembrane helix predicted for WP1082 by TMHMM2.0 at aa 5-27 570417004646 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004647 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 570417004648 quinone interaction residues [chemical binding]; other site 570417004649 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 570417004650 active site 570417004651 catalytic residues [active] 570417004652 FMN binding site [chemical binding]; other site 570417004653 substrate binding site [chemical binding]; other site 570417004656 PS00911 Dihydroorotate dehydrogenase signature 1. 570417004657 PS00912 Dihydroorotate dehydrogenase signature 2. 570417004658 ribonuclease III; Reviewed; Region: rnc; PRK00102 570417004659 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 570417004660 dimerization interface [polypeptide binding]; other site 570417004661 active site 570417004662 metal binding site [ion binding]; metal-binding site 570417004663 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 570417004664 dsRNA binding site [nucleotide binding]; other site 570417004667 PS00517 Ribonuclease III family signature. 570417004669 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 570417004670 Cu(I) binding site [ion binding]; other site 570417004672 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004673 1 probable transmembrane helix predicted for WP1085 by TMHMM2.0 at aa 7-26 570417004674 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 570417004675 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 570417004676 active site 570417004677 substrate binding site [chemical binding]; other site 570417004678 catalytic site [active] 570417004682 Tim44-like domain; Region: Tim44; cl09208 570417004684 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 570417004685 SecA binding site; other site 570417004686 Preprotein binding site; other site 570417004689 aconitate hydratase; Validated; Region: PRK09277 570417004690 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 570417004691 substrate binding site [chemical binding]; other site 570417004692 ligand binding site [chemical binding]; other site 570417004693 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 570417004694 substrate binding site [chemical binding]; other site 570417004697 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004698 PS00450 Aconitase family signature 1. 570417004699 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004700 PS01244 Aconitase family signature 2. 570417004702 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 570417004703 Proline dehydrogenase; Region: Pro_dh; cl03282 570417004704 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 570417004705 Glutamate binding site [chemical binding]; other site 570417004706 NAD binding site [chemical binding]; other site 570417004707 catalytic residues [active] 570417004711 PS00687 Aldehyde dehydrogenases glutamic acid active site. 570417004712 PS00070 Aldehyde dehydrogenases cysteine active site. 570417004713 Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459 570417004715 multifunctional aminopeptidase A; Provisional; Region: PRK00913 570417004716 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 570417004717 interface (dimer of trimers) [polypeptide binding]; other site 570417004718 Substrate-binding/catalytic site; other site 570417004719 Zn-binding sites [ion binding]; other site 570417004720 1 probable transmembrane helix predicted for WP1092 by TMHMM2.0 at aa 5-22 570417004723 PS00631 Cytosol aminopeptidase signature. 570417004724 NADH dehydrogenase subunit G; Validated; Region: PRK09130 570417004725 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 570417004726 catalytic loop [active] 570417004727 iron binding site [ion binding]; other site 570417004728 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 570417004729 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 570417004730 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 570417004733 PS00641 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. 570417004734 PS00642 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. 570417004735 PS00643 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. 570417004737 4 probable transmembrane helices predicted for WP1095 by TMHMM2.0 at aa 4-23, 49-71, 81-100 and 113-135 570417004738 NADH dehydrogenase; Region: NADHdh; cl00469 570417004739 8 probable transmembrane helices predicted for WP1096 by TMHMM2.0 at aa 2-24, 70-92, 113-135, 155-177, 189-208, 242-264, 277-299 and 314-336 570417004741 PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 570417004742 PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 570417004743 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 570417004744 dimer interface [polypeptide binding]; other site 570417004745 allosteric magnesium binding site [ion binding]; other site 570417004746 active site 570417004747 aspartate-rich active site metal binding site; other site 570417004748 Schiff base residues; other site 570417004750 PS00169 Delta-aminolevulinic acid dehydratase active site. 570417004751 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417004753 Putative transposase (pseudogene);Disrupted by IS insertion. 570417004754 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417004756 DNA polymerase I; Provisional; Region: PRK05755 570417004757 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 570417004758 active site 570417004759 metal binding site 1 [ion binding]; metal-binding site 570417004760 putative 5' ssDNA interaction site; other site 570417004761 metal binding site 3; metal-binding site 570417004762 metal binding site 2 [ion binding]; metal-binding site 570417004763 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 570417004764 putative DNA binding site [nucleotide binding]; other site 570417004765 putative metal binding site [ion binding]; other site 570417004766 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 570417004767 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 570417004768 active site 570417004769 DNA binding site [nucleotide binding] 570417004770 catalytic site [active] 570417004773 PS00447 DNA polymerase family A signature. 570417004776 1 probable transmembrane helix predicted for WP1101 by TMHMM2.0 at aa 21-43 570417004777 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 570417004778 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 570417004781 PS00571 Amidases signature. 570417004782 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 570417004783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 570417004784 ATP binding site [chemical binding]; other site 570417004785 Mg2+ binding site [ion binding]; other site 570417004786 G-X-G motif; other site 570417004787 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 570417004788 anchoring element; other site 570417004789 dimer interface [polypeptide binding]; other site 570417004790 ATP binding site [chemical binding]; other site 570417004791 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 570417004792 active site 570417004793 putative metal-binding site [ion binding]; other site 570417004794 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 570417004798 PS00177 DNA topoisomerase II signature. 570417004801 PS00070 Aldehyde dehydrogenases cysteine active site. 570417004802 2 probable transmembrane helices predicted for WP1104 by TMHMM2.0 at aa 36-58 and 90-112 570417004803 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417004804 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417004805 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417004806 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417004813 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 570417004815 1 probable transmembrane helix predicted for WP1106 by TMHMM2.0 at aa 13-35 570417004817 PS00389 ATP synthase delta (OSCP) subunit signature. 570417004818 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 570417004819 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 570417004820 8 probable transmembrane helices predicted for WP1107 by TMHMM2.0 at aa 20-38, 43-62, 77-95, 102-121, 136-158, 179-196, 201-223 and 230-252 570417004822 PS00379 CDP-alcohol phosphatidyltransferases signature. 570417004824 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 570417004825 11 probable transmembrane helices predicted for WP1108 by TMHMM2.0 at aa 15-37, 72-94, 99-121, 152-174, 184-203, 208-230, 245-267, 299-321, 350-369, 376-398 and 408-430 570417004828 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 570417004829 12 probable transmembrane helices predicted for WP1109 by TMHMM2.0 at aa 2-24, 44-66, 102-124, 129-151, 183-205, 225-244, 251-273, 283-305, 347-369, 384-406, 413-435 and 445-467 570417004832 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004833 Domain of unknown function (DUF205); Region: DUF205; cl00410 570417004835 5 probable transmembrane helices predicted for WP1110 by TMHMM2.0 at aa 4-23, 51-69, 79-101, 113-135 and 150-172 570417004837 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417004839 2 probable transmembrane helices predicted for WP1113 by TMHMM2.0 at aa 20-42 and 88-110 570417004840 Cation efflux family; Region: Cation_efflux; cl00316 570417004843 6 probable transmembrane helices predicted for WP1114 by TMHMM2.0 at aa 21-43, 47-64, 84-106, 121-138, 151-173 and 178-197 570417004844 surface protein-related protein (pseudogene) 570417004845 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 570417004846 1 probable transmembrane helix predicted for WP1116 by TMHMM2.0 at aa 43-60 570417004847 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 570417004848 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 570417004849 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 570417004853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 570417004854 Smr domain; Region: Smr; cl02619 570417004856 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 570417004857 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 570417004858 GIY-YIG motif/motif A; other site 570417004859 active site 570417004860 catalytic site [active] 570417004861 putative DNA binding site [nucleotide binding]; other site 570417004862 metal binding site [ion binding]; metal-binding site 570417004863 UvrB/uvrC motif; Region: UVR; pfam02151 570417004864 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 570417004870 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 570417004871 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 570417004874 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004876 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417004877 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 570417004878 motif 1; other site 570417004879 dimer interface [polypeptide binding]; other site 570417004880 active site 570417004881 motif 2; other site 570417004882 motif 3; other site 570417004885 5 probable transmembrane helices predicted for WP1123 by TMHMM2.0 at aa 33-55, 67-89, 109-131, 152-172 and 187-209 570417004886 putative transposase (pseudogene) 570417004887 1 probable transmembrane helix predicted for WP1125 by TMHMM2.0 at aa 49-71 570417004888 1 probable transmembrane helix predicted for WP1126 by TMHMM2.0 at aa 186-208 570417004889 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 570417004890 putative phosphate binding site [ion binding]; other site 570417004891 putative catalytic site [active] 570417004892 active site 570417004893 metal binding site A [ion binding]; metal-binding site 570417004894 DNA binding site [nucleotide binding] 570417004895 putative AP binding site [nucleotide binding]; other site 570417004896 putative metal binding site B [ion binding]; other site 570417004899 PS00728 AP endonucleases family 1 signature 3. 570417004900 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 570417004901 active site 570417004902 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 570417004904 1 probable transmembrane helix predicted for WP1129 by TMHMM2.0 at aa 64-86 570417004905 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 570417004906 Protein of unknown function (DUF972); Region: DUF972; cl01853 570417004907 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 570417004908 active site 570417004909 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 570417004910 substrate binding site [chemical binding]; other site 570417004911 metal binding site [ion binding]; metal-binding site 570417004913 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 570417004917 Colicin V production protein; Region: Colicin_V; cl00567 570417004919 4 probable transmembrane helices predicted for WP1132 by TMHMM2.0 at aa 5-24, 29-51, 64-86 and 101-123 570417004920 Lumazine binding domain; Region: Lum_binding; pfam00677 570417004921 Lumazine binding domain; Region: Lum_binding; pfam00677 570417004925 2 probable transmembrane helices predicted for WP1134 by TMHMM2.0 at aa 494-513 and 534-556 570417004926 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 570417004927 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 570417004928 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 570417004929 dimer interface [polypeptide binding]; other site 570417004930 motif 1; other site 570417004931 active site 570417004932 motif 2; other site 570417004933 motif 3; other site 570417004937 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 570417004938 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 570417004939 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 570417004940 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 570417004941 Substrate binding site; other site 570417004942 Mg++ binding site; other site 570417004943 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 570417004944 putative trimer interface [polypeptide binding]; other site 570417004945 putative CoA binding site [chemical binding]; other site 570417004951 Surface antigen; Region: Surface_Ag_2; cl01155 570417004952 Surface antigen; Region: Surface_Ag_2; cl01155 570417004953 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 570417004956 PS01169 Ribosomal protein L21 signature. 570417004957 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 570417004960 PS00831 Ribosomal protein L27 signature. 570417004961 S-adenosylmethionine synthetase; Validated; Region: PRK05250 570417004962 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 570417004963 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 570417004964 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 570417004968 PS00376 S-adenosylmethionine synthetase signature 1. 570417004970 PS00377 S-adenosylmethionine synthetase signature 2. 570417004971 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 570417004973 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 570417004975 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 570417004976 Subunit III/VIIa interface [polypeptide binding]; other site 570417004977 Phospholipid binding site [chemical binding]; other site 570417004978 Subunit I/III interface [polypeptide binding]; other site 570417004979 Subunit III/VIb interface [polypeptide binding]; other site 570417004980 Subunit III/VIa interface; other site 570417004981 Subunit III/Vb interface [polypeptide binding]; other site 570417004983 7 probable transmembrane helices predicted for WP1145 by TMHMM2.0 at aa 13-35, 39-61, 82-104, 139-161, 168-190, 210-232 and 252-274 570417004984 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 570417004985 active site 570417004986 putative DNA-binding cleft [nucleotide binding]; other site 570417004987 dimer interface [polypeptide binding]; other site 570417004990 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417004991 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417004993 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417004995 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 570417004998 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 570417004999 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 570417005000 Class I ribonucleotide reductase; Region: RNR_I; cd01679 570417005001 active site 570417005002 dimer interface [polypeptide binding]; other site 570417005003 catalytic residues [active] 570417005004 effector binding site; other site 570417005005 R2 peptide binding site; other site 570417005008 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 570417005009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 570417005010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 570417005011 S-adenosylmethionine binding site [chemical binding]; other site 570417005015 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 570417005017 PS00784 Ribosomal protein L34 signature. 570417005018 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 570417005019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 570417005020 dimer interface [polypeptide binding]; other site 570417005021 conserved gate region; other site 570417005022 putative PBP binding loops; other site 570417005023 ABC-ATPase subunit interface; other site 570417005024 9 probable transmembrane helices predicted for WP1156 by TMHMM2.0 at aa 4-23, 44-66, 76-98, 143-165, 180-202, 214-236, 263-285, 298-320 and 335-357 570417005027 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 570417005028 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 570417005029 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 570417005030 alpha subunit interaction interface [polypeptide binding]; other site 570417005031 Walker A motif; other site 570417005032 ATP binding site [chemical binding]; other site 570417005033 Walker B motif; other site 570417005034 inhibitor binding site; inhibition site 570417005035 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 570417005039 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005040 PS00152 ATP synthase alpha and beta subunits signature. 570417005042 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 570417005044 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 570417005045 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 570417005046 V-type ATP synthase subunit I; Validated; Region: PRK05771 570417005047 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 570417005048 active site 570417005049 intersubunit interactions; other site 570417005050 catalytic residue [active] 570417005053 PS01054 Transaldolase signature 1. 570417005054 3 probable transmembrane helices predicted for WP1161 by TMHMM2.0 at aa 15-37, 75-94 and 98-116 570417005055 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 570417005056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 570417005057 NAD(P) binding site [chemical binding]; other site 570417005058 active site 570417005059 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 570417005060 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 570417005061 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 570417005062 catalytic site [active] 570417005063 subunit interface [polypeptide binding]; other site 570417005066 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005068 PS00442 Glutamine amidotransferases class-I active site. 570417005069 elongation factor Tu; Reviewed; Region: PRK00049 570417005070 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 570417005071 G1 box; other site 570417005072 GEF interaction site [polypeptide binding]; other site 570417005073 GTP/Mg2+ binding site [chemical binding]; other site 570417005074 Switch I region; other site 570417005075 G2 box; other site 570417005076 G3 box; other site 570417005077 Switch II region; other site 570417005078 G4 box; other site 570417005079 G5 box; other site 570417005080 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 570417005081 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 570417005082 Antibiotic Binding Site [chemical binding]; other site 570417005086 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005087 PS00301 GTP-binding elongation factors signature. 570417005090 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 570417005093 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 570417005096 PS00474 Ribosomal protein L3 signature. 570417005097 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 570417005099 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 570417005101 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 570417005102 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 570417005103 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 570417005107 PS00467 Ribosomal protein L2 signature. 570417005108 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 570417005111 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 570417005112 putative translocon binding site; other site 570417005113 protein-rRNA interface [nucleotide binding]; other site 570417005116 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 570417005117 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 570417005118 G-X-X-G motif; other site 570417005119 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 570417005124 PS00548 Ribosomal protein S3 signature. 570417005125 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 570417005126 23S rRNA interface [nucleotide binding]; other site 570417005127 5S rRNA interface [nucleotide binding]; other site 570417005128 putative antibiotic binding site [chemical binding]; other site 570417005129 L25 interface [polypeptide binding]; other site 570417005130 L27 interface [polypeptide binding]; other site 570417005133 PS00586 Ribosomal protein L16 signature 1. 570417005134 PS00701 Ribosomal protein L16 signature 2. 570417005135 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 570417005136 putative translocon interaction site; other site 570417005137 signal recognition particle (SRP54) interaction site; other site 570417005138 L23 interface [polypeptide binding]; other site 570417005139 trigger factor interaction site; other site 570417005140 23S rRNA interface [nucleotide binding]; other site 570417005141 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 570417005143 PS00056 Ribosomal protein S17 signature. 570417005144 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 570417005146 PS00049 Ribosomal protein L14 signature. 570417005147 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 570417005148 KOW motif; Region: KOW; cl00354 570417005150 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 570417005151 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 570417005152 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 570417005154 PS00358 Ribosomal protein L5 signature. 570417005156 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 570417005158 PS00527 Ribosomal protein S14 signature. 570417005159 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 570417005161 PS00053 Ribosomal protein S8 signature. 570417005162 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 570417005163 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 570417005165 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 570417005166 23S rRNA interface [nucleotide binding]; other site 570417005167 L21e interface [polypeptide binding]; other site 570417005168 5S rRNA interface [nucleotide binding]; other site 570417005169 L27 interface [polypeptide binding]; other site 570417005170 L5 interface [polypeptide binding]; other site 570417005172 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 570417005173 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 570417005174 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 570417005178 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 570417005182 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 570417005183 SecY translocase; Region: SecY; pfam00344 570417005184 10 probable transmembrane helices predicted for WP1185 by TMHMM2.0 at aa 20-42, 76-98, 118-140, 155-177, 184-206, 216-238, 272-294, 314-336, 367-389 and 393-412 570417005187 PS00756 Protein secY signature 2. 570417005188 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 570417005189 adenylate kinases; Region: adk; TIGR01351 570417005190 AMP-binding site [chemical binding]; other site 570417005191 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 570417005193 PS00113 Adenylate kinase signature. 570417005194 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 570417005195 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 570417005197 1 probable transmembrane helix predicted for WP1187 by TMHMM2.0 at aa 15-34 570417005198 PS00646 Ribosomal protein S13 signature. 570417005199 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 570417005201 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417005202 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 570417005203 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 570417005204 alphaNTD homodimer interface [polypeptide binding]; other site 570417005205 alphaNTD - beta interaction site [polypeptide binding]; other site 570417005206 alphaNTD - beta' interaction site [polypeptide binding]; other site 570417005207 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 570417005212 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 570417005215 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 570417005216 1 probable transmembrane helix predicted for WP1191 by TMHMM2.0 at aa 7-29 570417005217 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 570417005218 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 570417005221 PS00436 Peroxidases active site signature. 570417005222 PS00389 ATP synthase delta (OSCP) subunit signature. 570417005223 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 570417005224 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 570417005225 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 570417005226 beta subunit interaction interface [polypeptide binding]; other site 570417005227 Walker A motif; other site 570417005228 ATP binding site [chemical binding]; other site 570417005229 Walker B motif; other site 570417005230 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 570417005234 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005235 PS00152 ATP synthase alpha and beta subunits signature. 570417005237 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 570417005238 domain; Region: GreA_GreB_N; pfam03449 570417005239 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 570417005243 PS00830 Prokaryotic transcription elongation factors signature 2. 570417005244 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 570417005247 Peptidase family M48; Region: Peptidase_M48; cl12018 570417005248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 570417005249 binding surface 570417005250 TPR motif; other site 570417005251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 570417005252 binding surface 570417005253 TPR motif; other site 570417005255 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 570417005256 TrbC/VIRB2 family; Region: TrbC; cl01583 570417005257 3 probable transmembrane helices predicted for WP1197 by TMHMM2.0 at aa 7-24, 44-66 and 73-95 570417005258 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 570417005259 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 570417005260 NAD(P) binding site [chemical binding]; other site 570417005261 homotetramer interface [polypeptide binding]; other site 570417005262 homodimer interface [polypeptide binding]; other site 570417005263 active site 570417005267 PS00061 Short-chain dehydrogenases/reductases family signature. 570417005268 putative transposase (pseudogene) 570417005269 1 probable transmembrane helix predicted for WP1200 by TMHMM2.0 at aa 15-37 570417005270 pyruvate phosphate dikinase; Provisional; Region: PRK09279 570417005271 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 570417005272 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 570417005273 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 570417005277 PS00370 PEP-utilizing enzymes phosphorylation site signature. 570417005279 PS00742 PEP-utilizing enzymes signature 2. 570417005280 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005281 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 570417005282 1 probable transmembrane helix predicted for WP1204 by TMHMM2.0 at aa 21-40 570417005284 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 570417005285 putative GSH binding site [chemical binding]; other site 570417005286 catalytic residues [active] 570417005289 BolA-like protein; Region: BolA; cl00386 570417005290 surface antigen, wsp paralog (pseudogene);Disrupted by IS insertion 570417005291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 570417005292 Transposase; Region: DEDD_Tnp_IS110; pfam01548 570417005293 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 570417005294 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 570417005295 Malic enzyme, N-terminal domain; Region: malic; pfam00390 570417005296 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 570417005297 putative NAD(P) binding site [chemical binding]; other site 570417005299 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417005301 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 570417005303 3 probable transmembrane helices predicted for WP1211 by TMHMM2.0 at aa 10-27, 34-56 and 151-173 570417005304 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417005306 PS00379 CDP-alcohol phosphatidyltransferases signature. 570417005307 Putative membrane protein (pseudogene) 570417005308 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 570417005309 Domain of unknown function DUF28; Region: DUF28; cl00361 570417005312 Peptidase family M23; Region: Peptidase_M23; pfam01551 570417005314 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 570417005315 3 probable transmembrane helices predicted for WP1216 by TMHMM2.0 at aa 20-42, 46-65 and 72-94 570417005317 PQ loop repeat; Region: PQ-loop; cl12056 570417005319 2 probable transmembrane helices predicted for WP1217 by TMHMM2.0 at aa 9-31 and 51-80 570417005320 Thiamine pyrophosphokinase; Region: TPK; cd07995 570417005321 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 570417005322 active site 570417005323 dimerization interface [polypeptide binding]; other site 570417005324 thiamine binding site [chemical binding]; other site 570417005327 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005328 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005329 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005330 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005331 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005332 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005333 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005334 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005335 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005336 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005349 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 570417005350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 570417005351 putative substrate translocation pore; other site 570417005353 12 probable transmembrane helices predicted for WP1221 by TMHMM2.0 at aa 9-31, 46-68, 75-97, 101-123, 135-157, 161-183, 210-232, 247-266, 279-299, 304-323, 336-358 and 362-384 570417005355 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 570417005356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 570417005357 S-adenosylmethionine binding site [chemical binding]; other site 570417005358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 570417005361 PS01183 ubiE/COQ5 methyltransferase family signature 1. 570417005364 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 570417005365 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 570417005366 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 570417005367 Walker A/P-loop; other site 570417005368 ATP binding site [chemical binding]; other site 570417005369 Q-loop/lid; other site 570417005370 ABC transporter signature motif; other site 570417005371 Walker B; other site 570417005372 D-loop; other site 570417005373 H-loop/switch region; other site 570417005375 4 probable transmembrane helices predicted for WP1223 by TMHMM2.0 at aa 15-37, 57-79, 147-169 and 237-259 570417005377 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005378 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417005380 PS00338 Somatotropin, prolactin and related hormones signature 2. 570417005381 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 570417005382 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 570417005383 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 570417005384 active site 570417005385 HIGH motif; other site 570417005386 KMSK motif region; other site 570417005387 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 570417005388 tRNA binding surface [nucleotide binding]; other site 570417005389 anticodon binding site; other site 570417005394 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 570417005396 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 570417005397 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417005398 Walker A/P-loop; other site 570417005399 ATP binding site [chemical binding]; other site 570417005400 Q-loop/lid; other site 570417005401 ABC transporter signature motif; other site 570417005402 Walker B; other site 570417005403 D-loop; other site 570417005404 H-loop/switch region; other site 570417005407 PS00211 ABC transporters family signature. 570417005408 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005409 1 probable transmembrane helix predicted for WP1229 by TMHMM2.0 at aa 4-23 570417005410 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 570417005411 MAEBL; Provisional; Region: PTZ00121 570417005412 Transposase, Mutator family; Region: Transposase_mut; pfam00872 570417005413 MULE transposase domain; Region: MULE; pfam10551 570417005415 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 570417005416 nucleoside/Zn binding site; other site 570417005417 dimer interface [polypeptide binding]; other site 570417005418 catalytic motif [active] 570417005420 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 570417005421 CTP synthetase; Validated; Region: pyrG; PRK05380 570417005422 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 570417005423 Catalytic site [active] 570417005424 active site 570417005425 UTP binding site [chemical binding]; other site 570417005426 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 570417005427 active site 570417005428 putative oxyanion hole; other site 570417005429 catalytic triad [active] 570417005432 PS00442 Glutamine amidotransferases class-I active site. 570417005434 Preprotein translocase SecG subunit; Region: SecG; cl09123 570417005436 2 probable transmembrane helices predicted for WP1236 by TMHMM2.0 at aa 13-35 and 69-91 570417005438 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 570417005439 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 570417005440 trimer interface [polypeptide binding]; other site 570417005441 putative metal binding site [ion binding]; other site 570417005447 2 probable transmembrane helices predicted for WP1239 by TMHMM2.0 at aa 178-197 and 202-224 570417005448 transposase (fragment) 570417005449 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 570417005450 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 570417005451 glutaminase active site [active] 570417005452 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 570417005453 dimer interface [polypeptide binding]; other site 570417005454 active site 570417005455 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 570417005456 dimer interface [polypeptide binding]; other site 570417005457 active site 570417005461 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417005463 Preprotein translocase subunit; Region: YajC; cl00806 570417005466 1 probable transmembrane helix predicted for WP1242 by TMHMM2.0 at aa 15-37 570417005467 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 570417005468 rRNA interaction site [nucleotide binding]; other site 570417005469 S8 interaction site; other site 570417005470 putative laminin-1 binding site; other site 570417005473 PS00963 Ribosomal protein S2 signature 2. 570417005475 elongation factor Ts; Provisional; Region: tsf; PRK09377 570417005476 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 570417005477 Elongation factor TS; Region: EF_TS; pfam00889 570417005478 Elongation factor TS; Region: EF_TS; pfam00889 570417005481 PS01126 Elongation factor Ts signature 1. 570417005483 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417005484 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 570417005485 putative nucleotide binding site [chemical binding]; other site 570417005486 uridine monophosphate binding site [chemical binding]; other site 570417005487 homohexameric interface [polypeptide binding]; other site 570417005490 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 570417005491 hinge region; other site 570417005494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 570417005495 Transposase, Mutator family; Region: Transposase_mut; pfam00872 570417005496 MULE transposase domain; Region: MULE; pfam10551 570417005498 transketolase; Provisional; Region: PTZ00089 570417005499 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 570417005500 Cation transport protein; Region: TrkH; cl10514 570417005501 12 probable transmembrane helices predicted for WP1250 by TMHMM2.0 at aa 9-31, 41-63, 70-92, 135-157, 178-200, 235-257, 269-286, 296-318, 325-347, 387-409, 416-438 and 453-475 570417005502 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417005504 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417005505 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417005506 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 570417005507 trimer interface [polypeptide binding]; other site 570417005508 active site 570417005510 1 probable transmembrane helix predicted for WP1252 by TMHMM2.0 at aa 31-53 570417005511 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 570417005512 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 570417005513 active site 570417005514 metal binding site [ion binding]; metal-binding site 570417005516 GTP cyclohydrolase; Provisional; Region: PRK08815 570417005517 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 570417005518 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 570417005519 dimerization interface [polypeptide binding]; other site 570417005520 active site 570417005522 VirB8 protein; Region: VirB8; cl01500 570417005523 1 probable transmembrane helix predicted for WP1255 by TMHMM2.0 at aa 34-56 570417005525 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 570417005526 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 570417005527 VirB7 interaction site; other site 570417005529 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 570417005530 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 570417005531 1 probable transmembrane helix predicted for WP1257 by TMHMM2.0 at aa 27-49 570417005533 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 570417005534 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 570417005535 Walker A motif; other site 570417005536 hexamer interface [polypeptide binding]; other site 570417005537 ATP binding site [chemical binding]; other site 570417005538 Walker B motif; other site 570417005540 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005541 type IV secretion system component VirD4; Provisional; Region: PRK13897 570417005542 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 570417005543 Walker A motif; other site 570417005544 ATP binding site [chemical binding]; other site 570417005545 Walker B motif; other site 570417005546 1 probable transmembrane helix predicted for WP1259 by TMHMM2.0 at aa 13-35 570417005548 PS00307 Legume lectins beta-chain signature. 570417005549 surface antigen wsp paralog (pseudogene);Disrupted by IS insertion 570417005550 Transposase, Mutator family; Region: Transposase_mut; pfam00872 570417005551 MULE transposase domain; Region: MULE; pfam10551 570417005553 DNA topoisomerase I; Validated; Region: PRK06599 570417005554 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 570417005555 active site 570417005556 interdomain interaction site; other site 570417005557 putative metal-binding site [ion binding]; other site 570417005558 nucleotide binding site [chemical binding]; other site 570417005559 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 570417005560 domain I; other site 570417005561 DNA binding groove [nucleotide binding] 570417005562 phosphate binding site [ion binding]; other site 570417005563 domain II; other site 570417005564 domain III; other site 570417005565 nucleotide binding site [chemical binding]; other site 570417005566 catalytic site [active] 570417005567 domain IV; other site 570417005568 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 570417005569 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 570417005573 PS00396 Prokaryotic DNA topoisomerase I active site. 570417005575 1 probable transmembrane helix predicted for WP1263 by TMHMM2.0 at aa 43-60 570417005576 metabolite-proton symporter; Region: 2A0106; TIGR00883 570417005577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 570417005578 putative substrate translocation pore; other site 570417005581 10 probable transmembrane helices predicted for WP1264 by TMHMM2.0 at aa 43-65, 80-102, 147-169, 179-201, 233-255, 270-292, 301-323, 327-349, 370-389 and 394-412 570417005582 PS00217 Sugar transport proteins signature 2. 570417005583 DNA repair protein RadA; Provisional; Region: PRK11823 570417005584 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 570417005585 Walker A motif/ATP binding site; other site 570417005586 ATP binding site [chemical binding]; other site 570417005587 Walker B motif; other site 570417005589 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005590 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 570417005591 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 570417005592 P loop; other site 570417005593 GTP binding site [chemical binding]; other site 570417005596 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005598 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 570417005599 trimerization site [polypeptide binding]; other site 570417005600 active site 570417005603 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 570417005606 PS01152 Hypothetical hesB/yadR/yfhF family signature. 570417005607 co-chaperone HscB; Provisional; Region: hscB; PRK05014 570417005608 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 570417005609 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 570417005612 Fe-S protein assembly chaperone HscA; Region: HscA; TIGR01991 570417005613 Wolbachia palindromic element (WPE) domain; Region: WPE_wolbac; TIGR02697 570417005615 PS00297 Heat shock hsp70 proteins family signature 1. 570417005616 PS00329 Heat shock hsp70 proteins family signature 2. 570417005617 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 570417005618 Catalytic site [active] 570417005619 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 570417005620 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 570417005622 PS00761 Signal peptidases I signature 3. 570417005624 PS00760 Signal peptidases I lysine active site. 570417005625 PS00501 Signal peptidases I serine active site. 570417005626 1 probable transmembrane helix predicted for WP1272 by TMHMM2.0 at aa 28-47 570417005627 TrbC/VIRB2 family; Region: TrbC; cl01583 570417005628 3 probable transmembrane helices predicted for WP1273 by TMHMM2.0 at aa 7-26, 41-63 and 70-92 570417005629 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 570417005630 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 570417005631 alpha subunit interface [polypeptide binding]; other site 570417005632 TPP binding site [chemical binding]; other site 570417005633 heterodimer interface [polypeptide binding]; other site 570417005634 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 570417005637 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005638 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005639 1 probable transmembrane helix predicted for WP1275 by TMHMM2.0 at aa 371-393 570417005641 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417005643 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 570417005644 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 570417005645 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 570417005646 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 570417005648 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005649 PS00687 Aldehyde dehydrogenases glutamic acid active site. 570417005650 PS00211 ABC transporters family signature. 570417005652 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005653 PS00211 ABC transporters family signature. 570417005654 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 570417005655 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 570417005656 1 probable transmembrane helix predicted for WP1278 by TMHMM2.0 at aa 29-51 570417005657 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005658 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 570417005659 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005660 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005661 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005663 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417005669 2 probable transmembrane helices predicted for WP1279 by TMHMM2.0 at aa 290-312 and 317-339 570417005670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 570417005671 ATP binding site [chemical binding]; other site 570417005672 Walker A motif; other site 570417005673 Walker B motif; other site 570417005674 arginine finger; other site 570417005675 2 probable transmembrane helices predicted for WP1280 by TMHMM2.0 at aa 7-29 and 39-61 570417005677 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005678 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417005679 PS00674 AAA-protein family signature. 570417005680 1 probable transmembrane helix predicted for WP1281 by TMHMM2.0 at aa 15-32 570417005681 conserved hypothetical protein (pseudogene) 570417005682 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417005684 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature. 570417005685 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417005687 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; pfam02902 570417005688 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 570417005689 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005693 putative transposase (pseudogene) 570417005695 prophage 5 570417005696 Protein of unknown function (DUF1016); Region: DUF1016; cl01979 570417005698 Uncharacterized conserved protein [Function unknown]; Region: COG4104 570417005699 PAAR motif; Region: PAAR_motif; pfam05488 570417005700 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 570417005703 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 570417005704 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 570417005705 tandem repeat interface [polypeptide binding]; other site 570417005706 oligomer interface [polypeptide binding]; other site 570417005707 active site residues [active] 570417005709 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 570417005712 Protein of unknown function (DUF1016); Region: DUF1016; cl01979 570417005714 gpW; Region: gpW; pfam02831 570417005715 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; cl05448 570417005716 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 570417005718 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005719 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005720 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005721 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005722 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005723 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005724 2 probable transmembrane helices predicted for WP1308 by TMHMM2.0 at aa 406-428 and 432-454 570417005725 ParB-like nuclease domain; Region: ParBc; cl02129 570417005726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 570417005727 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 570417005728 active site 570417005729 putative DNA-binding cleft [nucleotide binding]; other site 570417005730 dimer interface [polypeptide binding]; other site 570417005731 hypothetical protein; Validated; Region: PRK07078 570417005732 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 570417005733 active site 570417005734 metal binding site [ion binding]; metal-binding site 570417005735 interdomain interaction site; other site 570417005736 Hexameric Replicative Helicase RepA. RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125 570417005737 Walker A motif; other site 570417005738 NTP binding site [chemical binding]; other site 570417005739 hexamer interface [polypeptide binding]; other site 570417005740 Walker B motif; other site 570417005741 2 probable transmembrane helices predicted for WP1313 by TMHMM2.0 at aa 24-46 and 50-72 570417005742 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 570417005743 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 570417005744 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005745 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417005746 Walker A motif; other site 570417005747 ATP binding site [chemical binding]; other site 570417005748 Walker B motif; other site 570417005749 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005750 C2 domain; Region: C2; cl14603 570417005751 hypothetical protein; Validated; Region: PRK07078 570417005752 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417005753 ATP binding site [chemical binding]; other site 570417005754 Walker A motif; other site 570417005755 Walker B motif; other site 570417005756 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005757 PS00881 Protein splicing signature. 570417005758 PLC-beta C terminal; Region: PLC-beta_C; pfam08703 570417005759 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 570417005760 Phage tail tube protein FII; Region: Phage_tube; cl01390 570417005762 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 570417005764 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 570417005765 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 570417005767 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005768 3 probable transmembrane helices predicted for WP1333 by TMHMM2.0 at aa 514-536, 543-565 and 575-597 570417005769 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 570417005771 Phage Tail Protein X; Region: Phage_tail_X; cl02088 570417005774 Phage protein D [General function prediction only]; Region: COG3500; cl12180 570417005775 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 570417005777 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005778 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005779 1 probable transmembrane helix predicted for WP1337 by TMHMM2.0 at aa 12-31 570417005782 1 probable transmembrane helix predicted for WP1338 by TMHMM2.0 at aa 7-26 570417005783 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 570417005784 putative active site [active] 570417005785 catalytic site [active] 570417005786 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 570417005787 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 570417005788 active site 570417005789 nucleophile elbow; other site 570417005791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 570417005792 non-specific DNA binding site [nucleotide binding]; other site 570417005793 salt bridge; other site 570417005794 sequence-specific DNA binding site [nucleotide binding]; other site 570417005795 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 570417005796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 570417005797 non-specific DNA binding site [nucleotide binding]; other site 570417005798 salt bridge; other site 570417005799 sequence-specific DNA binding site [nucleotide binding]; other site 570417005800 hypothetical protein; Reviewed; Region: PRK00024 570417005801 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 570417005802 MPN+ (JAMM) motif; other site 570417005803 Zinc-binding site [ion binding]; other site 570417005804 Putative transcriptional regulator (pseudogene);Hit against Lamda repressor and helx-turn-helix motifs using Interproscan 570417005805 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 570417005806 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 570417005807 Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340 570417005808 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 570417005809 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 570417005810 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 570417005811 6 probable transmembrane helices predicted for WP1346 by TMHMM2.0 at aa 2928-2950, 2967-2989, 2994-3016, 3037-3059, 3072-3094 and 3101-3123 570417005812 PS00012 Phosphopantetheine attachment site. 570417005814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 570417005815 Transposase; Region: DEDD_Tnp_IS110; pfam01548 570417005816 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 570417005817 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 570417005818 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417005820 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 570417005821 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 570417005822 HSP70 interaction site [polypeptide binding]; other site 570417005823 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005824 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005825 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005826 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005827 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005832 2 probable transmembrane helices predicted for WP1351 by TMHMM2.0 at aa 671-693 and 695-714 570417005833 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 570417005834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 570417005835 RmuC family; Region: RmuC; pfam02646 570417005836 1 probable transmembrane helix predicted for WP1356 by TMHMM2.0 at aa 2-23 570417005838 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 570417005839 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 570417005842 Transposase, Mutator family; Region: Transposase_mut; pfam00872 570417005843 MULE transposase domain; Region: MULE; pfam10551 570417005845 Protein of unknown function (DUF1016); Region: DUF1016; cl01979 570417005847 gpW; Region: gpW; pfam02831 570417005848 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 570417005849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 570417005850 Ferredoxin [Energy production and conversion]; Region: COG1146 570417005851 4Fe-4S binding domain; Region: Fer4; cl02805 570417005852 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 570417005854 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 570417005856 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 570417005857 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 570417005860 transposase (pseudogene) 570417005863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 570417005864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 570417005865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 570417005866 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 570417005867 peptide chain release factor 2; Region: prfB; TIGR00020 570417005868 RF-1 domain; Region: RF-1; cl02875 570417005869 RF-1 domain; Region: RF-1; cl02875 570417005872 PS00745 Prokaryotic-type class I peptide chain release factors signature. 570417005874 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 570417005875 MgtE intracellular N domain; Region: MgtE_N; cl15244 570417005876 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 570417005877 Divalent cation transporter; Region: MgtE; cl00786 570417005881 4 probable transmembrane helices predicted for WP1376 by TMHMM2.0 at aa 293-315, 365-387, 394-416 and 431-453 570417005883 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 570417005884 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005885 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005886 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005887 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005888 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005889 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005897 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005898 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005899 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005900 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 570417005901 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 570417005910 1 probable transmembrane helix predicted for WP1380 by TMHMM2.0 at aa 7-29 570417005911 UbiA prenyltransferase family; Region: UbiA; cl00337 570417005912 7 probable transmembrane helices predicted for WP1381 by TMHMM2.0 at aa 15-36, 43-65, 85-107, 114-136, 156-178, 221-243 and 269-291 570417005915 PS00943 UbiA prenyltransferase family signature. 570417005916 Ribosome-binding factor A; Region: RBFA; cl00542 570417005918 translation initiation factor IF-2; Region: IF-2; TIGR00487 570417005919 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 570417005920 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 570417005921 G1 box; other site 570417005922 putative GEF interaction site [polypeptide binding]; other site 570417005923 GTP/Mg2+ binding site [chemical binding]; other site 570417005924 Switch I region; other site 570417005925 G2 box; other site 570417005926 G3 box; other site 570417005927 Switch II region; other site 570417005928 G4 box; other site 570417005929 G5 box; other site 570417005930 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 570417005931 Translation-initiation factor 2; Region: IF-2; pfam11987 570417005932 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 570417005938 PS00017 ATP/GTP-binding site motif A (P-loop). 570417005940 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 570417005941 NusA N-terminal domain; Region: NusA_N; pfam08529 570417005942 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 570417005943 RNA binding site [nucleotide binding]; other site 570417005944 homodimer interface [polypeptide binding]; other site 570417005945 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 570417005946 G-X-X-G motif; other site 570417005947 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 570417005953 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 570417005954 Protein export membrane protein; Region: SecD_SecF; cl14618 570417005956 11 probable transmembrane helices predicted for WP1385 by TMHMM2.0 at aa 15-32, 336-358, 368-390, 430-449, 464-486, 532-554, 851-870, 877-899, 903-925, 957-979 and 999-1021 570417005957 2 probable transmembrane helices predicted for WP1386 by TMHMM2.0 at aa 12-34 and 38-55 570417005958 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 570417005959 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120